Thibaut Vaulet, Jasper Callemeyn, Baptiste Lamarthée, Asier Antoranz, Tim Debyser, Priyanka Koshy, Dany Anglicheau, Jill Colpaert, Wilfried Gwinner, Philip F Halloran, Dirk Kuypers, Claire Tinel, Amaryllis Van Craenenbroeck, Elisabet Van Loon, Pierre Marquet, Francesca Bosisio, Maarten Naesens
BACKGROUND: The link between the histology of kidney transplant rejection, especially Antibody-mediated rejection, T cell-mediated rejection and Mixed rejection, and the types of infiltrating immune cells is currently not well charted. Cost and technical complexity of single cell analysis hinder large scale studies of the relationship between cell infiltrate profiles and histological heterogeneity. METHODS: In this cross-sectional study, we assessed the composition of nine intragraft immune cell types by using a validated kidney transplant-specific signature matrix for deconvolution of bulk transcriptomics in three different kidney transplant biopsy datasets (N=403, N=224, N=282)...
April 19, 2024: Journal of the American Society of Nephrology: JASN