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https://www.readbyqxmd.com/read/28748904/native-kidney-posttransplant-lymphoproliferative-disorder-in-a-renal-transplant-recipient
#1
Abhilash Chandra, Anupama Kaul, Vinita Aggarwal, Divya Srivastava
Compared with the general population, cancer risk in kidney transplant recipients is much higher. In the present study, we report a patient who was diagnosed with posttransplant lymphoproliferative disorder (PTLD) and had a fulminant course, dying within few days of diagnosis. This case report highlights the importance of timely detection and treatment of PTLD as it is associated with high mortality rate.
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748883/epidemiology-and-outcome-of-tuberculosis-in-immunocompromised-patients
#2
Abdul Massiah Metry, Issa Al Salmi, Seif Al-Abri, Faisal Al Ismaili, Yaqoub Al Mahrouqi, Alan Hola, Faissal A M Shaheen
The United States Renal Data System showed 1.2% and 1.6% incidences of tuberculosis (TB) in patients on peritoneal dialysis and hemodialysis (HD), respectively. Kidney transplant (KTX) patients have higher rates. We studied the epidemiology and outcome of TB in patients with kidney dysfunction in a tertiary care hospital in the past decade. We examined data of patients with TB with and without kidney dysfunction from 2006 to 2015 through an electronic system. Statistical analysis was completed using Stata software, Chicago, IL, USA...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748879/early-clinical-manifestations-and-laboratory-findings-before-and-after-treatment-of-cytomegalovirus-infection-in-kidney-transplant-patients
#3
Wasim Ahmed Siddiqui, Issa Al Salmi, Amitabh Jha, Abbas Pakkyara, Mohammad Yasir, Faissal A M Shaheen
Cytomegalovirus (CMV) is one of the most frequently encountered opportunistic viral pathogens in kidney transplant recipients. In this study, we retrospectively reviewed all living related and unrelated kidney transplant recipients on regular follow-up from January 2006 to June 2015, who were suspected to have CMV clinically and confirmed by DNA polymerase chain reaction (PCR). CMV PCR was detected in 102 kidney transplant recipients. The median time of detection after kidney transplant was 21 months, ranging from 15 days to 84 months...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748876/end-stage-renal-disease-in-patients-with-sickle-cell-disease
#4
Ahmed M Alkhunaizi, Adil A Al-Khatti, Samir H Al-Mueilo, Abdulrazack Amir, Bedri Yousif
Sickle cell nephropathy is a severe complication of sickle cell disease (SCD) that has a wide range of manifestations, from asymptomatic microalbuminuria to end-stage renal disease (ESRD). The data on patients with SCD who develop ESRD are scarce. The aim of this study was to explore the course of patients with SCD who developed ESRD and received renal replacement therapy (RRT). The course of patients with SCD who developed ESRD and started dialysis at two centers in the Eastern Province of Saudi Arabia was retrospectively analyzed...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748581/coronary-artery-calcium-may-stabilize-following-islet-cell-transplantation-in-patients-with-type-1-diabetes
#5
J M Madrigal, R S Monson, B Hatipoglu, J Oberholzer, G T Kondos, K A Varady, K K Danielson
Islet cell transplantation can functionally cure type 1 diabetes, and also improve carotid-intima media thickness. This study provides a preliminary description of changes in coronary artery calcium following islet transplantation, and associated factors. Coronary artery calcium was measured in 14 patients with type 1 diabetes (11 had measures both pre- and post-transplant [mean 2.3 years]) in the University of Illinois at Chicago's clinical trial. Multivariable mixed-effects linear regression of repeated measures was used to quantify calcium change, and determine if this change was longitudinally associated with risk/protective factors...
July 27, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28748575/kidney-transplantation-in-ghana-is-the-public-ready
#6
Vincent Boima, Vincent Ganu, Dzifa Dey, Ernest Yorke, Alfred Yawson, Yvonne Otchere, Stella Nartey, Anna Gyaban-Mensah, Margaret Lartey, C Charles Mate-Kole
BACKGROUND: The burden of End Stage Renal Disease (ESRD) is reported to be higher among people of African ancestry. Majority do not have access to kidney transplantation. Africans in general, are less likely to donate a kidney or receive a transplant. AIMS: The present study surveyed public perceptions of kidney transplantation in an inner city and suburban communities in Ghana. It examined people's willingness to either accept or donate a kidney to save a life...
July 27, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28747579/effect-of-earlier-proteinuria-on-graft-functions-after-one-year-living-donor-renal-transplantation
#7
Zaiyou Dai, Luxi Ye, Dajin Chen, Xing Zhang, Meifang Wang, Rending Wang, Jianyong Wu, Jianghua Chen
BACKGROUND: Proteinuria is an indicator of subsequent renal function decline in most nephropathies and early proteinuria has been assumed to be a risk factor of poor kidney transplant outcomes. However, there is no information about the effect of earlier-proteinuria at the first week on short-term graft function after living donor renal transplantation. METHODS: Retrospective cohort study of 439 living donor kidney transplants to analyze the effect of early proteinuria at 7-day post-transplantation on short-term prognosis of living donor renal transplantation...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747139/a-monoclonal-antibody-against-cd86-and-its-protection-in-a-murine-lupus-nephritis-model-of-chronic-graft-versus-host-disease
#8
Lianhua Han, Lijun Shen, Ying Zhu, Yuhua Qiu
CONTEXT: Lupus nephritis is the most common complication that causes the death of systemic lupus erythematosus patients. CD28/CTLA4 and their ligands CD80 or CD86 costimulatory pathway play a pivotal role in autoimmune disease and organ transplantation. OBJECTIVES: We generated a monoclonal antibody (clone 1D1) against human CD86 (1D1) that could recognize both human and mouse CD86, and blocked the CD86/CD28 costimulatory pathway with our mAb on a murine lupus nephritis model induced with chronic graft-versus-host disease (cGVHD)...
July 26, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28747071/a-hibernation-like-state-for-transplantable-organs-is-h-sub-2-sub-s-therapy-the-future-of-organ-preservation
#9
George Dugbartey, Hjalmar Bouma, Manujendra N Saha, Ian Lobb, Robert H Henning, Alp Sener
Renal transplantation is the treatment of choice for end-stage renal disease, during which renal grafts from deceased donors are routinely cold stored to suppress metabolic demand and thereby limit ischemic injury. However, prolonged cold storage followed by reperfusion induces extensive tissue damage termed cold ischemia/reperfusion injury (IRI) and puts the graft at risk of both early and late rejection. The underlying mechanism of IRI is not completely understood and a reliable/ suitable method to protect the renal graft against cold IRI is lacking...
July 26, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28746791/living-donor-follow-up-unfunded-mandates-and-the-hippocratic-oath-where-perfect-may-be-the-enemy-of-good
#10
EDITORIAL
D Sudan
Kidney transplantation in patients with endstage renal disease (ESRD) provides far superior patient survival compared to chronic dialysis. The USRDS report from 2016 demonstrated that the average 3-year survival for patients with ESRD on hemo- or peritoneal dialysis was 56% and 67%, respectively compared to 84% and 91% 3-year survival after deceased donor (DD) and living donor (LD) kidney transplantation (KT), respectively.(1) Despite superior patient survival, rates of living donation have decreased since 2005...
July 26, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28746700/risk-factors-for-melanoma-in-renal-transplant-recipients
#11
Mona Ascha, Mustafa S Ascha, Joseph Tanenbaum, Jeremy S Bordeaux
Importance: Melanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians. Objective: To determine risk factors and characteristics of renal transplant recipients who develop melanoma. Design, Setting, and Participants: This cohort study of a large national data registry used a cohort of renal transplant recipients from the United States Renal Data System (USRDS) database from the years 2004 through 2012...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28744628/infection-related-hospitalizations-after-kidney-transplantation-in-children-incidence-risk-factors-and-cost
#12
Julien Hogan, Christine Pietrement, Anne-Laure Sellier-Leclerc, Ferielle Louillet, Rémi Salomon, Marie-Alice Macher, Etienne Berard, Cécile Couchoud
BACKGROUND: Infection is the leading cause of death and hospitalization in renal transplant recipients. We describe posttransplant infections requiring hospitalization, their risk factors and cost in a national pediatric kidney transplantation cohort. METHODS: Data on renal transplant recipients <20 years were extracted from the French National Medicoadministrative Hospital Discharge database between 2008 and 2013 and matched with the Renal Transplant Database...
July 25, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28743539/recommendations-of-everolimus-use-in-liver-transplant
#13
Angel Rubín Suárez, Itxarone Bilbao Aguirre, Javier Fernández-Castroagudin, José Antonio Pons Miñano, Magdalena Salcedo Plaza, Evaristo Varo Pérez, Martín Prieto Castillo
Mammalian target of rapamycin (mTOR) inhibitors, everolimus (EVL) and sirolimus are immunosuppressive agents with a minor nephrotoxic effect, limited to the development of proteinuria in some cases. The combination of EVL and low-dose tacrolimus has proven to be as safe and effective as standard therapy with tacrolimus for the prevention of acute cellular rejection. Early initiation of EVL-based immunosuppressive regimens with reduced exposure to calcineurin inhibitors has been shown to significantly improve renal function of LT recipients during induction and maintenance phases, with comparable efficacy and safety profiles...
July 22, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28742936/benefits-and-limitations-of-belatacept-in-4-hand-transplanted-patients
#14
J Grahammer, A Weissenbacher, B G Zelger, B Zelger, C Boesmueller, M Ninkovic, A Mühlbacher, I Peschel, G Brandacher, D Öfner, S Schneeberger
Belatacept (CTLA4Ig) is an emerging treatment in kidney transplantation. Lack of nephrotoxicity and possibly an inhibitory effect on the development of donor specific antibodies (DSA) make it an interesting agent in hand transplantation. In order to reduce CNI immunosuppression and preserve kidney function, we have added belatacept to the therapeutic regimen of 4 hand transplanted patients at month 4, at 6, 9, and 13 years after hand/forearm transplantation. Patients received 5mg/kg belatacept every 2 weeks, the dosing interval was extended to 4 weeks after 5 applications...
July 25, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28742776/venovenous-bypass-is-associated-with-a-lower-incidence-of-acute-kidney-injury-after-liver-transplantation-in-patients-with-compromised-pretransplant-renal-function
#15
Kai Sun, Fu Hong, Yun Wang, Vatche G Agopian, Min Yan, Ronald W Busuttil, Randolph H Steadman, Victor W Xia
BACKGROUND: Although the hemodynamic benefits of venovenous bypass (VVB) during liver transplantation (LT) are well appreciated, the impact of VVB on posttransplant renal function is uncertain. The aim of this study was to determine if VVB was associated with a lower incidence of posttransplant acute kidney injury (AKI). METHODS: Medical records of adult (≥18 years) patients who underwent primary LT between 2004 and 2014 at a tertiary hospital were reviewed. Patients who required pretransplant renal replacement therapy and intraoperative piggyback technique were excluded...
July 21, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28742762/kdigo-clinical-practice-guideline-on-the-evaluation-and-care-of-living-kidney-donors
#16
Krista L Lentine, Bertram L Kasiske, Andrew S Levey, Patricia L Adams, Josefina Alberú, Mohamed A Bakr, Lorenzo Gallon, Catherine A Garvey, Sandeep Guleria, Philip Kam-Tao Li, Dorry L Segev, Sandra J Taler, Kazunari Tanabe, Linda Wright, Martin G Zeier, Michael Cheung, Amit X Garg
The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors is intended to assist medical professionals who evaluate living kidney donor candidates and provide care before, during and after donation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach and guideline recommendations are based on systematic reviews of relevant studies that included critical appraisal of the quality of the evidence and the strength of recommendations...
August 2017: Transplantation
https://www.readbyqxmd.com/read/28742255/weight-management-strategies-for-those-with-chronic-kidney-disease-a-consensus-report-from-the-asia-pacific-society-of-nephrology-and-australia-and-new-zealand-society-of-nephrology-2016-renal-dietitians-meeting
#17
Kelly Lambert, Jo Beer, Ruth Dumont, Katie Hewitt, Karen Manley, Anthony Meade, Karen Salamon, Katrina Campbell
AIM: Develop a consensus report to guide dietetic management of overweight or obese individuals with Chronic Kidney Disease (CKD). METHODS: Six statements relating weight management in CKD guided a comprehensive review of the literature. A summary of the evidence was then presented at the renal nutrition meeting of the 2016 Asia Pacific Society of Nephrology and Australia and New Zealand Society of Nephrology. Majority agreement was defined as group agreement on a statement of between 50-74%, and consensus was considered ≥ 75% agreement...
July 25, 2017: Nephrology
https://www.readbyqxmd.com/read/28742013/first-canadian-experience-with-donation-after-cardiac-death-simultaneous-pancreas-and-kidney-transplants
#18
Patrick T Anderson, Shahid Aquil, Kelly McLean, Vivian C McAlister, Alp Sener, Patrick P Luke
BACKGROUND: Compared with neurologic determination of death (NDD) donor organs, donation after cardiac death (DCD) donor organs have traditionally been considered of inferior quality owing to warm ischemia experienced during procurement. We present, to our knowledge, the first analysis of simultaneous pancreas and kidney (SPK) transplants using DCD donor organs in Canada. METHODS: We carried out a retrospective cohort study of SPK transplants from 13 DCD and 68 NDD donors performed between October 2008 and July 2016...
August 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28741797/risk-factors-and-long-term-outcomes-of-parvovirus-b19-infection-in-kidney-transplant-patients
#19
Chung Hee Baek, Hyosang Kim, Won Soek Yang, Duck Jong Han, Su-Kil Park
BACKGROUND: Parvovirus B19 is a small, non-enveloped, single-stranded DNA virus with a special affinity for the erythroid progenitor cells of the bone marrow. The first case of parvovirus B19 infection in a kidney transplant recipient (KTR) was reported in 1986. Data on the risk factors and specific clinical characteristics of parvovirus B19 infection remain insufficient. METHODS: We screened 602 KTRs for parvovirus B19 infection using parvovirus B19 polymerase chain reaction (PCR) from January 1990 to April 2016, and the clinical characteristics of patients with positive results were compared to those of age- and gender-matched patients with negative PCR results...
July 25, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28741050/risk-factors-for-progression-of-chronic-kidney-disease-in-the-eppic-trials-and-the-effect-of-ast-120
#20
Gerald Schulman, Tomas Berl, Gerald J Beck, Giuseppe Remuzzi, Eberhard Ritz, Miho Shimizu, Mami Kikuchi, Yuko Shobu
BACKGROUND: Two randomized, double-blind, placebo-controlled trials (EPPIC-1 and EPPIC-2) investigated the efficacy and safety of AST-120, an oral spherical carbon adsorbent, in adults with chronic kidney disease (CKD). While the benefit of adding AST-120 to standard therapy was not supported by these trials, we performed a post hoc analysis to focus on CKD progression and to determine the risk factors for the primary endpoint in the EPPIC trial population. METHODS: In the EPPIC trials, patients were randomly assigned 1:1 to treatment with AST-120 or placebo...
July 24, 2017: Clinical and Experimental Nephrology
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