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https://www.readbyqxmd.com/read/28928638/affective-circuitry-alterations-in-patients-with-trigeminal-neuralgia
#1
Dave J Hayes, David Q Chen, Jidan Zhong, Ariel Lin, Brendan Behan, Matthew Walker, Mojgan Hodaie
Trigeminal neuralgia (TN) is a severe chronic neuropathic facial pain disorder. Affect-related behavioral and structural brain changes have been noted across chronic pain disorders, but have not been well-studied in TN. We examined the potential impact of TN (37 patients: 23 with right-sided TN, 14 with left-sided TN), compared to age- and sex-matched healthy controls, on three major white matter tracts responsible for carrying affect-related signals-i.e., cingulum, fornix, and medial forebrain bundle. Diffusion magnetic resonance imaging (dMRI), deterministic multi-tensor tractography for tract modeling, and a model-driven region-of-interest approach was used...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28927719/sex-dependent-behavioral-impairments-in-the-hdhq350-mouse-line
#2
Jessica K Cao, Peter J Detloff, Richard G Gardner, Nephi Stella
Huntington's Disease (HD) is an autosomal dominant neurodegenerative disease characterized by gradual deterioration of motor and cognitive functions and development of psychiatric deficits. Animal models provide powerful means to study the pathological processes, molecular dysfunctions and symptoms associated with HD. We performed a longitudinal behavioral study of the newly developed HdhQ350/+ mouse line, a knock-in model that expresses a repeat of 350 glutamines. We found remarkable sex-dependent differences on symptom onset and severity...
September 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28924013/reward-related-ventral-striatum-activity-buffers-against-the-experience-of-depressive-symptoms-associated-with-sleep-disturbances
#3
Reut Avinun, Adam Nevo, Annchen R Knodt, Maxwell L Elliott, Spenser R Radtke, Bartholomew D Brigidi, Ahmad R Hariri
Sleep disturbances represent one risk factor for depression. Reward-related brain function, particularly the activity of the ventral striatum (VS), has been identified as a potential buffer against stress-related depression. We were therefore interested in testing whether reward-related VS activity would moderate the effect of sleep disturbances on depression in a large cohort of young adults. Data were available from 1129 university students (mean age 19.71 ± 1.25 years; 637 women) who completed a reward-related functional MRI task to assay VS activity and provided self-reports of sleep using the Pittsburgh Sleep Quality Index and symptoms of depression using a summation of the General Distress/Depression (GDD) and Anhedonic Depression (AD) subscales of the Mood and Anxiety Symptoms Questionnaire-short form...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28923189/gender-differences-in-sleep-disorders-in-the-us-military
#4
Shannon N Foster, Shana L Hansen, Dale C Capener, Panagiotis Matsangas, Vincent Mysliwiec
OBJECTIVES: The purpose of this study is to compare sleep disorders between male and female military personnel. Comorbid behavioral health disorders and chronic pain were also studied in relation to sleep disorders. DESIGN: We conducted a retrospective review of military personnel who underwent a sleep medicine evaluation and an in-laboratory attended polysomnography. Initial sleep questionnaires, demographics, polysomnographic variables, and comorbid disorders of interest were reviewed and compared for each sex...
October 2017: Sleep Health
https://www.readbyqxmd.com/read/28906162/effects-of-tinnitus-treatments-on-sleep-disorders-in-patients-with-tinnitus
#5
Satoko Wakabayashi, Hideyuki Saito, Naoki Oishi, Seiichi Shinden, Kaoru Ogawa
OBJECTIVE: To assess the effects of tinnitus treatments on sleep disorders in patients with tinnitus. DESIGN: Subjects completed the Pittsburg Sleep Quality Index (PSQI), Tinnitus Handicap Inventory (THI), Self-rating Depression Scale (SDS), and State Trait Anxiety Inventory (STAI). The questionnaire results and the patients' sex, age, time since the onset of tinnitus, and mean hearing level were examined, and differences between a sleep disorder group and a normal sleep group were examined...
September 14, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28904986/sex-matters-repetitive-mild-traumatic-brain-injury-in-adolescent-rats
#6
David K Wright, Terence J O'Brien, Sandy R Shultz, Richelle Mychasiuk
OBJECTIVE: Whether sex differences contribute to the heterogeneity of mild traumatic brain injury (mTBI) and repeated mTBI (RmTBI) outcomes in adolescents is unknown. Therefore, this study examined changes in, and differences between, male and female rats following single mTBI and RmTBI. METHODS: Rats were given a single mTBI, RmTBI (i.e., 3x), or sham injuries. Injuries were administered using a lateral impact model that mimics forces common in human mTBI. After the final injury, rats underwent extensive behavioral testing to examine cognition, motor function, and anxiety- and depressive-like behavior...
September 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28903161/national-trends-in-suicide-attempts-among-adults-in-the-united-states
#7
Mark Olfson, Carlos Blanco, Melanie Wall, Shang-Min Liu, Tulshi D Saha, Roger P Pickering, Bridget F Grant
Importance: A recent increase in suicide in the United States has raised public and clinical interest in determining whether a coincident national increase in suicide attempts has occurred and in characterizing trends in suicide attempts among sociodemographic and clinical groups. Objective: To describe trends in recent suicide attempts in the United States. Design, Setting, and Participants: Data came from the 2004-2005 wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) and the 2012-2013 NESARC-III...
September 13, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28892504/clinical-impact-of-depression-and-anxiety-in-patients-with-idiopathic-pulmonary-fibrosis
#8
Ye Jin Lee, Sun Mi Choi, Yeon Joo Lee, Young-Jae Cho, Ho Il Yoon, Jae-Ho Lee, Choon-Taek Lee, Jong Sun Park
BACKGROUND: Although depression and anxiety represent significant yet treatable comorbidities in patients with idiopathic pulmonary fibrosis (IPF), their impact on the clinical course and prognosis of IPF remain unclear. PURPOSE: We investigated the prevalence and clinical significance of depression and anxiety in patients with IPF. METHODS: The present study included a prospective cohort comprising 112 Korean patients with IPF who had completed the Hospital Anxiety and Depression Scale (HADS) questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28887095/psychological-distress-in-patients-undergoing-surgery-for-urological-cancer-a-single-centre-cross-sectional-study
#9
Antonio Luigi Pastore, Ana Mir, Serena Maruccia, Giovanni Palleschi, Antonio Carbone, Cristina Lopez, Nuria Camps, Joan Palou
PURPOSE: Interest in the disease-specific psychological well-being of patients with cancer has increased, and it has been estimated that less than half of all patients with cancer are properly identified and subsequently treated for anxiety or depression. The aim of this study is to evaluate psychological distress in uro-oncological patients undergoing different surgeries: radical cystectomy, radical prostatectomy, radical nephrectomy, or transurethral resection (TUR) before the surgery...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28879250/dental-care-related-fear-and-anxiety-distress-tolerance-as-a-possible-mechanism
#10
S H Addicks, D W McNeil, C L Randall, A Goddard, L M Romito, C Sirbu, G Kaushal, A Metzger, B D Weaver
Distress tolerance, the degree to which one is able to cope with and endure negative emotional states, has been broadly applied to understand and treat a variety of health (including behavioral) problems, but little is known about its role in oral health care and specifically dental care-related fear and anxiety, making it a novel construct in the oral health care literature. This cross-sectional study examined distress tolerance as a possible predictor of dental fear and anxiety among a sample of adults with and without diagnoses of dental phobia, investigated possible differences in levels of distress tolerance between adults with and without dental phobia, and determined possible associations between distress tolerance and fear of pain, anxiety sensitivity, and depression...
July 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28877512/sex-dependent-neural-effect-of-oxytocin-during-subliminal-processing-of-negative-emotion-faces
#11
Lizhu Luo, Benjamin Becker, Yayuan Geng, Zhiying Zhao, Shan Gao, Weihua Zhao, Shuxia Yao, Xiaoxiao Zheng, Xiaole Ma, Zhao Gao, Jiehui Hu, Keith M Kendrick
In line with animal models indicating sexually dimorphic effects of oxytocin (OXT) on social-emotional processing, a growing number of OXT-administration studies in humans have also reported sex-dependent effects during social information processing. To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86-43 males) with a backward-masking emotional face paradigm...
September 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28874596/a-double-blind-randomized-placebo-controlled-trial-of-panax-ginseng-for-cancer-related-fatigue-in-patients-with-advanced-cancer
#12
Sriram Yennurajalingam, Nizar M Tannir, Janet L Williams, Zhanni Lu, Kenneth R Hess, Susan Frisbee-Hume, Helen L House, Zita Dubauskas Lim, Kyu-Hyoung Lim, Gabriel Lopez, Akhila Reddy, Ahsan Azhar, Angelique Wong, Sunil M Patel, Deborah A Kuban, Ahmed Omar Kaseb, Lorenzo Cohen, Eduardo Bruera
Background: Despite the high frequency, severity, and effects of cancer-related fatigue (CRF) on the quality of life (QoL) of patients with cancer, limited treatment options are available. The primary objective of this study was to compare the effects of oral Panax ginseng extract (PG) and placebo on CRF. Secondary objectives were to determine the effects of PG on QoL, mood, and function. Methods: In this randomized, double-blind, placebo-controlled study, patients with CRF ≥4/10 on the Edmonton Symptom Assessment System (ESAS) were eligible...
September 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28872524/the-influence-of-arthritis-in-other-major-joints-and-the-spine-on-the-one-year-outcome-of-total-hip-replacement-a-prospective-multicenter-cohort-study-eurohip-measuring-the-influence-of-musculoskeletal-morbidity
#13
Joerg Huber, Paul Dieppe, Karsten Dreinhoefer, Klaus-Peter Günther, Andrew Judge
BACKGROUND: Although arthritis in other affected major joints and back pain are known to lead to worse outcomes following total hip replacement, to our knowledge, these risk factors have not previously been operationalized as a musculoskeletal morbidity profile. The aim of this study was to measure the influence of other major joints and the spine (as grades of musculoskeletal morbidity) on the 1-year outcome of primary total hip replacement. METHODS: The EUROHIP study consists of 1,327 patients undergoing primary total hip replacement for arthritis across 20 European orthopaedic centers...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28872406/the-levels-and-predictors-of-physical-activity-engagement-within-the-treatment-seeking-transgender-population-a-matched-control-study
#14
Bethany A Jones, Emma Haycraft, Walter Bouman, Jon Arcelus
BACKGROUND: Physical activity has been found to alleviate mental health problems and could be beneficial for at-risk populations, such as transgender people. This study had three aims. First, to explore the amount of physical activity that treatment seeking transgender people engage in, and to compare this to matched cisgender people. Second, to determine whether there was a difference in physical activity depending on cross-sex hormone use. Third, to determine factors which predict physical activity among treatment seeking transgender people...
September 5, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28867417/increased-psychiatric-morbidity-in-women-with-complete-androgen-insensitivity-syndrome-or-complete-gonadal-dysgenesis
#15
Hedvig Engberg, Anna Strandqvist, Anna Nordenström, Agnieszka Butwicka, Agneta Nordenskjöld, Angelica Lindén Hirschberg, Louise Frisén
OBJECTIVE: Knowledge concerning mental health outcomes is important to optimize the health of individuals with disorders or differences of sex development (DSD). Thus, the aim of this study was to estimate if the prevalence of psychiatric morbidity in adult women diagnosed with complete androgen insensitivity syndrome (CAIS) or complete gonadal dysgenesis (46,XY GD and 46,XX GD) differs from that in women with premature ovarian insufficiency (POI) or age-matched population controls. METHODS: This cross-sectional study was conducted at the Karolinska University Hospital, Stockholm, Sweden, and included 33 women with different DSDs: 20 CAIS, 6 46,XY GD, 7 46,XX GD, 21 women with POI and 61 population-derived controls...
August 8, 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28867416/negative-affect-as-mediator-between-emotion-regulation-and-medically-unexplained-symptoms
#16
Jeanine Schwarz, Winfried Rief, Anna Radkovsky, Matthias Berking, Maria Kleinstäuber
BACKGROUND: Research on emotion regulation (ER) in medically unexplained physical symptoms (MUS) is rare. PURPOSE: The goal of this study was to compare ER skills between MUS-patients without comorbid depression, MUS-patients with comorbid depression (MUS+MDD), patients with major depressive disorder (MDD), and healthy controls. Additionally, we examined the mediating effect of depression and anxiety on the relationship between ER and somatization. METHODS: The Emotion-Regulation Skills Questionnaire (ERSQ) and other self-report measures were completed by 138 MUS-patients, 114 MUS+MDD-patients, 106 MDD-patients, and 100 healthy controls...
August 10, 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28865445/distinctive-subgroups-derived-by-cluster-analysis-based-on-pain-and-psychological-symptoms-in-swedish-older-adults-with-chronic-pain-a-population-study-pains65
#17
Britt Larsson, Björn Gerdle, Lars Bernfort, Lars-Åke Levin, Elena Dragioti
BACKGROUND: Improved knowledge based on clinical features of chronic pain in older adults would be valuable in terms of patient-orientated approaches and would provide support for health care systems in optimizing health care resources. This study identifies subgroups based on pain and psychological symptoms among Swedish older adults in the general population and compares derived subgroups with respect to socio-demographics, health aspects, and health care costs. METHODS: This cross-sectional study uses data collected from four registers and one survey...
September 2, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28858657/the-classification-of-body-dysmorphic-disorder-symptoms-in-male-and-female-adolescents
#18
Sophie C Schneider, Andrew J Baillie, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
BACKGROUND: Body dysmorphic disorder (BDD) was categorised in DSM-5 within the newly created 'obsessive-compulsive and related disorders' chapter, however this classification remains subject to debate. Confirmatory factor analysis was used to test competing models of the co-occurrence of symptoms of BDD, obsessive-compulsive disorder, unipolar depression, anxiety, and eating disorders in a community sample of adolescents, and to explore potential sex differences in these models. METHODS: Self-report questionnaires assessing disorder symptoms were completed by 3149 Australian adolescents...
August 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28856337/neurobiological-and-systemic-effects-of-chronic-stress
#19
Bruce S McEwen
The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor, which promote adaptation ("allostasis") but also contribute to pathophysiology ("allostatic load/overload") when overused and dysregulated. The adult as well as developing brain possesses a remarkable ability to show structural and functional plasticity in response to stressful and other experiences, including neuronal replacement, dendritic remodeling and synapse turnover...
January 2017: Chronic stress
https://www.readbyqxmd.com/read/28853004/sex-specific-issues-in-eating-disorders-a-clinical-and-psychopathological-investigation
#20
Stefano Valente, Giulia Di Girolamo, Martina Forlani, Anna Biondini, Paolo Scudellari, Diana De Ronchi, Anna Rita Atti
OBJECTIVE: To highlight the characteristics of eating disorders (ED) in males, with particular attention to sex-related clinical features and psychiatric co-morbidities. METHOD: Out of 280 persons, referred to our outpatients ED clinic between January 2011 and June 2014, 267 with complete information were included in this retrospective observational study. RESULTS: The men/women ratio was one to five (male 16.5% vs female 83.5%) with an increasing proportion of male patients over the years...
August 29, 2017: Eating and Weight Disorders: EWD
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