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sex differences; anxiety

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https://www.readbyqxmd.com/read/28544613/qtl-and-systems-genetics-analysis-of-mouse-grooming-and-behavioral-responses-to-novelty-in-an-open-field
#1
Anna Delprato, Marie-Paule Algéo, Brice Bonheur, Jason A Bubier, Lu Lu, Robert W Williams, Elissa J Chesler, Wim E Crusio
The open field is a classic test used to assess exploratory behavior, anxiety, and locomotor activity in rodents. Here we mapped quantitative trait loci (QTLs) underlying behaviors displayed in an open field, using a panel of 53 BXD recombinant inbred mouse strains with deep replication (10 per strain and sex). The use of these strains permits the integration and comparison of data obtained in different laboratories, and also offers the possibility to study trait covariance by exploiting powerful bioinformatics tools and resources...
May 24, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28541768/sex-differences-in-the-presentation-of-body-dysmorphic-disorder-in-a-community-sample-of-adolescents
#2
Sophie C Schneider, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
The current study sought to explore sex differences in the presentation of probable full-syndrome and subthreshold body dysmorphic disorder (BDD) in adolescents from an Australian community sample. Specifically, it examined sex differences in the types of BDD symptoms endorsed, body areas of concern, and the association with elevated symptoms of comorbid disorders. In male participants, it also compared the presenting features of those with and without muscle dysmorphia. Of 3,149 adolescents assessed using self-report questionnaires, 162 (5...
May 25, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28536974/neonatal-immune-challenge-with-lipopolysaccharide-triggers-long-lasting-sex-and-age-related-behavioral-and-immune-neurotrophic-alterations-in-mice-relevance-to-autism-spectrum-disorders
#3
Charllyany Sabino Custódio, Bruna Stefânia Ferreira Mello, Adriano José Maia Chaves Filho, Camila Nayane de Carvalho Lima, Rafaela Carneiro Cordeiro, Fábio Miyajima, Gislaine Z Réus, Silvânia Maria Mendes Vasconcelos, Tatiana Barichello, João Quevedo, Antônio Carlos de Oliveira, David Freitas de Lucena, Danielle S Macedo
Early-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic factor-BDNF) alterations were determined in the prefrontal cortex (PFC), hippocampus (HC), and hypothalamus (HT)...
May 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28535700/interactions-between-four-gene-polymorphisms-and-their-association-with-patients-with-parkinson-s-disease-in-a-chinese-han-population
#4
Zhanyun Lv, Wenjing Tian, Qianqian Ma, Yanlei Hao, Yan Yang
The four previously reported Parkinson's disease (PD)-related single-nucleotide polymorphisms (SNPs)-rs1775143, rs823114, rs2071746, and rs62063857-have rarely been studied in Chinese Han populations. To examine the association between these SNPs and PD, we conducted a case-control study of 158 patients with PD and 210 controls. All participants were Chinese Han from Northern China. With covariate adjustment for clinical characteristics, logistic regression analysis revealed no differences in genotype or allele frequencies for the four SNPs...
May 24, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28533034/psychiatric-disorders-and-function-in-adolescents-with-tetralogy-of-fallot
#5
Jennifer E Holland, Adam R Cassidy, Christian Stopp, Matthew T White, David C Bellinger, Michael J Rivkin, Jane W Newburger, David R DeMaso
OBJECTIVES: To assess psychiatric disorders and function in adolescents with repaired tetralogy of Fallot (TOF) without and with a genetic diagnosis and to evaluate associations of functioning with medical factors, IQ, and demographics. STUDY DESIGN: Adolescents with TOF (n = 91) and 87 healthy referents completed a clinician-rated structured psychiatric interview, parent-/self-report measures of psychopathology, and brain magnetic resonance imaging. Twenty-three of the adolescents with TOF had a known genetic diagnosis...
May 19, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28529362/study-of-sexual-functioning-and-disorder-in-women-before-and-after-tubal-sterilization-tubectomy
#6
Shweta Patil Kunkeri, T S Sathyanarayana Rao, Chittaranjan Andrade
INTRODUCTION: Sexual relationship is a basis for mental health and continuity of the healthy generation. There are very few studies on the female sexual functioning, especially in India. Sterilization being the most common contraceptive method, sexual functioning in women undergoing this surgical intervention has not been adequately explored. Available studies have found conflicting results; some have reported that sterilization has positive effects on sexual functioning since anxiety of getting pregnant is abolished...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28528227/treatment-non-response-associations-with-smoking-expectancies-among-treatment-seeking-smokers
#7
Lorra Garey, Samar A Taha, Brooke Y Kauffman, Kara F Manning, Clayton Neighbors, Norman B Schmidt, Michael J Zvolensky
Despite the high rate of smoking cessation treatment non-response, relatively little empirical work has examined predictors of treatment non-response. The present study sought to explore the effect of smoking outcome expectancies on treatment response in a sample of treatment-seeking adult daily smokers (N=182; 53.3% female; Mage=40.67; SD=13.63). Results indicated that expectancies for smoking to reduce negative affect were related to an increased likelihood of treatment non-response (OR=0.73, CI: 0.54, 0...
May 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28527657/clinical-outcomes-and-cost-effectiveness-of-brief-guided-parent-delivered-cognitive-behavioural-therapy-and-solution-focused-brief-therapy-for-treatment-of-childhood-anxiety-disorders-a-randomised-controlled-trial
#8
Cathy Creswell, Mara Violato, Hannah Fairbanks, Elizabeth White, Monika Parkinson, Gemma Abitabile, Alessandro Leidi, Peter J Cooper
BACKGROUND: Half of all lifetime anxiety disorders emerge before age 12 years; however, access to evidence-based psychological therapies for affected children is poor. We aimed to compare the clinical outcomes and cost-effectiveness of two brief psychological treatments for children with anxiety referred to routine child mental health settings. We hypothesised that brief guided parent-delivered cognitive behavioural therapy (CBT) would be associated with better clinical outcomes than solution-focused brief therapy and would be cost-effective...
May 17, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28525828/peripheral-immune-factors-are-elevated-in-women-with-current-or-recent-alcohol-dependence-and-associated-with-altered-mood-and-memory
#9
Clare J Wilhelm, Bret E Fuller, Marilyn Huckans, Jennifer M Loftis
BACKGROUND: The adverse effects of alcohol on brain function result, in part, from inflammatory processes. The sex-specific neuropsychiatric consequences and inflammatory status of active alcohol dependence and early remission from dependence have not been investigated. METHODS: Neuropsychiatric symptoms, inflammatory factors, and liver enzymes were compared in a prospective cohort study of adults with (n=51) or without (n=31) a current or recent history of alcohol dependence...
May 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28505062/relationships-between-depression-and-anxiety-symptoms-scores-and-blood-pressure-in-young-adults
#10
Sunil K Bhat, Lawrence J Beilin, Monique Robinson, Sally Burrows, Trevor A Mori
BACKGROUND: Depression and anxiety are risk factors for cardiovascular disease, but their relationship to blood pressure (BP) is less clear. Age-related comorbidity and lifestyle factors may confound these relationships. This study aimed to assess the relationships among BP, depression and anxiety symptom scores and self-reported history of depression in young adults. METHOD: Data on 1014 participants aged 20 years from the Western Australian Cohort (Raine) Study were analyzed for cross-sectional associations between clinic BP and Depression, Anxiety, Stress Scale questionnaire scores or a reported history of depression, accounting for relevant confounders...
May 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28502781/checks-and-balances-the-glucocorticoid-receptor-and-nf%C3%A4-b-in-good-times-and-bad
#11
REVIEW
Mandakh Bekhbat, Sydney A Rowson, Gretchen N Neigh
Mutual regulation and balance between the endocrine and immune systems facilitate an organism's stress response, and are impaired following chronic stress or prolonged immune activation. Concurrent alterations in stress physiology and immunity are increasingly recognized as contributing factors to several stress-linked neuropsychiatric disorders including depression, anxiety, and post-traumatic stress disorder. Accumulating evidence suggests that impaired balance and crosstalk between the glucocorticoid receptor (GR) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) - effectors of the endocrine and immune axes, respectively - may play a key role in mediating the harmful effects of chronic stress on mood and behavior...
May 11, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28490870/pre-and-post-bronchodilator-airway-obstruction-are-associated-with-similar-clinical-characteristics-but-different-prognosis-report-from-a-population-based-study
#12
Sami Sawalha, Linnea Hedman, Eva Rönmark, Bo Lundbäck, Anne Lindberg
INTRODUCTION: According to guidelines, the diagnosis of COPD should be confirmed by post-bronchodilator (post-BD) airway obstruction on spirometry; however, in clinical practice, this is not always performed. The aim of this population-based study was to compare clinical characteristics and prognosis, assessed as mortality, between subjects with airway obstruction divided into pre- but not post-BD obstruction, post-BD airway obstruction (COPD), and subjects without airway obstruction...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28473760/persistent-effects-of-developmental-exposure-to-17%C3%AE-ethinylestradiol-on-the-zebrafish-danio-rerio-brain-transcriptome-and-behavior
#13
Tove Porseryd, Kristina Volkova, Nasim Reyhanian Caspillo, Thomas Källman, Patrik Dinnetz, Inger Porsh Hällström
The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting compound of concern due to its persistence and widespread presence in the aquatic environment. Effects of developmental exposure to low concentrations of EE2 in fish on reproduction and behavior not only persisted to adulthood, but have also been observed to be transmitted to several generations of unexposed progeny. To investigate the possible biological mechanisms of the persistent anxiogenic phenotype, we exposed zebrafish embryos for 80 days post fertilization to 0, 3, and 10 ng/L EE2 (measured concentrations 2...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28473351/sex-differences-in-the-association-between-area-deprivation-and-generalised-anxiety-disorder-british-population-study
#14
Olivia Remes, Nick Wainwright, Paul Surtees, Louise Lafortune, Kay-Tee Khaw, Carol Brayne
OBJECTIVE: Studies have shown that area-level deprivation measured by factors, such as non-home ownership, non-car ownership and household overcrowding, can increase the risk for mental disorders over and above individual-level circumstances, such as education and social class. Whether area-level deprivation is associated with generalised anxiety disorder (GAD) independent of personal circumstances, and whether this association is different between British women and men is unknown. DESIGN: Large, population study...
May 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28471256/gender-differences-in-the-transmission-of-smoking-from-filipino-parents-to-their-offspring-the-role-of-parenting-school-climate-and-negative-emotions
#15
Dan Jerome Barrera
OBJECTIVE: This article examines gender differences in the transmission of smoking, and the role of parenting, school climate, and negative emotions in the parental smoking-adolescent smoking relationship. METHODS: The study used a nationally representative cross-sectional data on 5,290 Filipino secondary students. RESULTS: Results suggest that Filipino adolescents having parents who smoke, tend to smoke cigarettes. Maternal smoking affects both girls' and boys' smoking, but paternal smoking has no effect on both sexes...
May 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28466438/a-mechanistic-cohort-study-evaluating-cognitive-impairment-in-women-treated-for-breast-cancer
#16
Janette L Vardy, Myrle M Stouten-Kemperman, Gregory Pond, Christopher M Booth, Sean B Rourke, Haryana M Dhillon, Anna Dodd, Adrian Crawley, Ian F Tannock
Some women report cognitive impairment after adjuvant chemotherapy (CTh) for breast cancer. Here we explore cognitive function, and underlying mechanisms with blood tests and functional magnetic resonance imaging (fMRI). Women treated for early breast cancer were recruited to three groups based on self-reported cognitive symptoms (CS) using FACT-Cog scores. CTh + CS+ (n = 44) had received chemotherapy and self-reported cognitive symptoms; CTh + CS- (n = 52) had chemotherapy but did not report cognitive problems; CTh- (n = 30) had not received chemotherapy...
May 2, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28465360/male-sex-associated-with-increased-risk-of-neonatal-abstinence-syndrome
#17
M Katherine Charles, William O Cooper, Lauren M Jansson, Judith Dudley, James C Slaughter, Stephen W Patrick
BACKGROUND: Neonatal abstinence syndrome (NAS) is a postnatal opioid withdrawal syndrome. Factors associated with development of the syndrome are poorly understood; however, infant sex may influence the risk of NAS. Our objective was to determine if infant sex was associated with the development or severity of the syndrome in a large population-based cohort. METHODS: This retrospective cohort study used vital statistics and prescription, outpatient, and inpatient administrative data for mothers and infants enrolled in the Tennessee Medicaid program between 2009 and 2011...
May 2, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28462362/early-life-stress-leads-to-developmental-and-sex-selective-effects-on-performance-in-a-novel-object-placement-task
#18
Kevin G Bath, Arielle Schilit Nitenson, Ezra Lichtman, Chelsea Lopez, Whitney Chen, Meghan Gallo, Haley Goodwill, Gabriela Manzano-Nieves
Disruptions in early life care, including neglect, extreme poverty, and trauma, influence neural development and increase the risk for and severity of pathology. Significant sex disparities have been identified for affective pathology, with females having an increased risk of developing anxiety and depressive disorder. However, the effects of early life stress (ELS) on cognitive development have not been as well characterized, especially in reference to sex specific impacts of ELS on cognitive abilities over development...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28458117/risk-of-mood-disorders-in-patients-with-colorectal-cancer
#19
Li-Min Sun, Ji-An Liang, Cheng-Li Lin, Sean Sun, Chia-Hung Kao
BACKGROUND: To assess the risk of mood disorders among patients with colorectal cancer (CRC), a population-based cohort study was performed using the Taiwanese National Health Insurance Research Database. METHODS: The study cohort included 27242 patients diagnosed with CRC between January 1, 2000 and December 31, 2010. Four insurants from the general population without CRC were frequency matched to each case by age, sex, and index year/month to create the control group...
April 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28452713/decreased-uncinate-fasciculus-tract-integrity-in-male-and-female-patients-with-ptsd-a-diffusion-tensor-imaging-study
#20
Saskia B J Koch, Mirjam van Zuiden, Laura Nawijn, Jessie L Frijling, Dick J Veltman, Miranda Olff
BACKGROUND: Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder that has been associated with lower white matter integrity of tracts connecting the prefrontal cortex with limbic regions. However, previous diffusion tensor imaging (DTI) findings have been inconsistent, showing high variability in the exact location and direction of effects. METHODS: We performed probabilistic tractography of the bilateral uncinate fasciculus, cingulum and superior longitudinal fasciculus (both temporal and parietal projections) in male and female police officers with and without PTSD...
April 28, 2017: Journal of Psychiatry & Neuroscience: JPN
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