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https://www.readbyqxmd.com/read/28719498/incidence-of-active-tuberculosis-and-cohort-retention-among-adolescents-in-western-kenya
#1
Videlis Nduba, Anna H Van't Hoog, Ellen M H Mitchell, Martien Borgdorff, Kayla F Laserson
SETTING: Siaya County, with the highest tuberculosis notification rates in Kenya. OBJECTIVE: To determine the incidence of active tuberculosis and one year cohort retention in 12-18 year old adolescents, in preparation for Phase III tuberculosis vaccine trials. METHODS: Adolescents were enrolled and followed up for 1-2 years to determine tuberculosis incidence. Adolescents with a positive tuberculin skin test (TST), history of cohabitation with a tuberculosis case, or at least one tuberculosis symptom received clinical and sputum examination and a chest radiograph...
July 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28718928/accessing-support-and-empowerment-online-the-experiences-of-individuals-with-diabetes
#2
Ellen Brady, Julia Segar, Caroline Sanders
CONTEXT: The use of the internet for health information by those with long-term conditions is growing. It has been argued that this represents a form of empowerment by patients, as it enables them to control the content and flow of the information available to them. To explore this, the use of online discussion groups by those with diabetes was examined. METHOD: Semi-structured interviews were conducted with 21 participants with type 1 and 2 diabetes and analysed using thematic analysis...
July 18, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28718760/cd25-expression-and-outcomes-in-older-patients-with-acute-myelogenous-leukemia-treated-with-plerixafor-and-decitabine
#3
John N Allan, Gail J Roboz, Gulce Askin, Ellen Ritchie, Joseph Scandura, Paul Christos, Duane C Hassane, Monica L Guzman
We investigated CD25 expression in older (≥60 years) patients with new acute myelogenous leukemia treated with decitabine and plerixafor. Patients resistant to therapy or survival ≤1 year had significantly higher percentages of CD25(pos) myeloid blasts in baseline bone marrow. CD25(pos) patients had an increased odds of resistance compared to CD25(neg) patients (p = .015). In univariate analysis, we found CD25(pos) patients had inferior survival compared to CD25(neg) (p = .002). In patients with intermediate risk cytogenetics, CD25(pos) status stratified patients associating with inferior survival (p = ...
July 18, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28718622/graphene-sheet-induced-global-maturation-of-cardiomyocytes-derived-from-human-induced-pluripotent-stem-cells
#4
Jiaxian Wang, Chang Cui, Haiyan Nan, Yuanfang Yu, Yini Xiao, Ellen Poon, Gang Yang, Xijie Wang, Chenchen Wang, Lingsong Li, Kenneth Richard Boheler, Xu Ma, Xin Cheng, Zhenhua Ni, Minglong Chen
Human induced pluripotent stem cells (hiPSCs) can proliferate infinitely. Their ability to differentiate into cardiomyocytes provides abundant sources for disease modeling, drug screening and regenerative medicine. However, hiPSC-derived cardiomyocytes (hiPSC-CMs) display a low degree of maturation and fetal-like properties. Current in vitro differentiation methods do not mimic the structural, mechanical, and physiological properties of the cardiogenesis niche. Recently, we present an efficient cardiac maturation platform that combines hiPSCs monolayer cardiac differentiation with graphene substrate which is a biocompatible and superconductive material...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718346/effect-of-desvenlafaxine-50-mg-and-100-mg-on-energy-and-lassitude-in-patients-with-major-depressive-disorder-a-pooled-analysis
#5
Raymond W Lam, Dalia B Wajsbrot, Ellen Meier, Elizabeth Pappadopulos, Joan A Mackell, Matthieu Boucher
Nine randomized, double-blind, placebo-controlled studies of major depressive disorder were pooled to evaluate the effects of desvenlafaxine 50- and 100-mg/d on energy and lassitude in adults with major depressive disorder ( n=4279). Changes from baseline to endpoint in 17-item Hamilton Rating Scale for Depression (HAM-D17) Work and Activities, Retardation, and Somatic Symptoms General items, HAM-D17 psychomotor retardation factor, and Montgomery-Åsberg Depression Rating Scale Lassitude item were analyzed with a mixed model for repeated measures analysis of variance...
July 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28718186/intrauterine-growth-restriction-iugr-induces-signs-of-subclinical-atherosclerosis-in-6-year-old-infants-despite-absence-of-excessive-growth
#6
Anja Tzschoppe, Rüdiger von Kries, Ellen Struwe, Wolfgang Rascher, Helmuth-Guenther Dörr, Jörg Jüngert, Manfred Rauh, Matthias Beckmann, Ralf Schild, Tamme W Goecke, Jörg Dötsch
Background Postnatal catch-up growth and rapid weight gain after intrauterine growth restriction (IUGR) seem to increase the risk for later disease. This study aimed to compare features of the metabolic syndrome early in life between IUGR and appropriate for gestational age (AGA) infants. Patients Data for 9 infants with IUGR defined by a birth weight<10(th) percentile and ultrasound-proven placental insufficiency and 11 AGA children were available. Method Postnatal growth, auxological, cardiovascular, and metabolic parameters up to a chronological age of 6 years were assessed: Fasting serum concentrations of LDL-cholesterol, insulin, leptin, IGF-I, DHEAS, skinfold thicknesses, blood pressure, and mean carotid intima-media thickness (cIMT)...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28717841/variation-in-care-for-surgical-patients-with-colorectal-cancer-protocol-adherence-in-12-european-hospitals
#7
Ruben van Zelm, Ellen Coeckelberghs, Walter Sermeus, Anthony De Buck van Overstraeten, Arved Weimann, Deborah Seys, Massimiliano Panella, Kris Vanhaecht
PURPOSE: Surgical care for patients with colorectal cancer has become increasingly standardized. The Enhanced Recovery After Surgery (ERAS) protocol is a widely accepted structured care method to improve postoperative outcomes of patients after surgery. Despite growing evidence of effectiveness, adherence to the protocol remains challenging in practice. This study was designed to assess the adherence rate in daily practice and examine the relationship between the importance of interventions and adherence rate...
July 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28717594/effect-of-freshwater-mussels-on-the-vertical-distribution-of-anaerobic-ammonia-oxidizers-and-other-nitrogen-transforming-microorganisms-in-upper-mississippi-river-sediment
#8
Ellen M Black, Michael S Chimenti, Craig L Just
Targeted qPCR and non-targeted amplicon sequencing of 16S rRNA genes within sediment layers identified the anaerobic ammonium oxidation (anammox) niche and characterized microbial community changes attributable to freshwater mussels. Anammox bacteria were normally distributed (Shapiro-Wilk normality test, W-statistic =0.954, p = 0.773) between 1 and 15 cm depth and were increased by a factor of 2.2 (p < 0.001) at 3 cm below the water-sediment interface when mussels were present. Amplicon sequencing of sediment at depths relevant to mussel burrowing (3 and 5 cm) showed that mussel presence reduced observed species richness (p = 0...
2017: PeerJ
https://www.readbyqxmd.com/read/28717128/mother-s-pre-pregnancy-bmi-and-placental-candidate-mirnas-findings-from-the-environage-birth-cohort
#9
Maria Tsamou, Dries S Martens, Ellen Winckelmans, Narjes Madhloum, Bianca Cox, Wilfried Gyselaers, Tim S Nawrot, Karen Vrijens
There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child's predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA alterations in placental tissue at birth. In 211 mother-newborn pairs from the ENVIRONAGE birth cohort, we assessed placental expression of seven miRNAs important in crucial cellular processes implicated in adipogenesis and/or obesity...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716949/biochemical-regulatory-features-of-aid-remain-conserved-from-lamprey-to-humans
#10
Emma M Quinlan, Justin J King, Chris T Amemiya, Ellen Hsu, Mani Larijani
Activation induced cytidine deaminase (AID) is a genome-mutating enzyme that initiates class switch recombination and somatic hypermutation of antibodies in jawed vertebrates. We previously described the biochemical properties of human AID and found that it is an unusual enzyme in that it exhibits binding affinities for its substrate DNA and catalytic rates several orders of magnitude higher and lower, respectively, than a typical enzyme. Recently, we solved the functional structure of AID and demonstrated that these properties are due to non-specific DNA binding on its surface, along with a catalytic pocket that predominantly assumes a closed conformation...
July 17, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28716889/cytokines-transcription-factors-and-the-initiation-of-t-cell-development
#11
Hiroyuki Hosokawa, Ellen V Rothenberg
Multipotent blood progenitor cells migrate into the thymus and initiate the T-cell differentiation program. T-cell progenitor cells gradually acquire T-cell characteristics while shedding their multipotentiality for alternative fates. This process is supported by extracellular signaling molecules, including Notch ligands and cytokines, provided by the thymic microenvironment. T-cell development is associated with dynamic change of gene regulatory networks of transcription factors, which interact with these environmental signals...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28716023/retraction-note-to-extranuclear-er%C3%AE-is-associated-with-regression-of-t47d-pkc%C3%AE-overexpressing-tamoxifen-resistant-breast-cancer
#12
Bethany Perez White, Mary Ellen Molloy, Huiping Zhao, Yiyun Zhang, Debra A Tonetti
No abstract text is available yet for this article.
July 17, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28715522/using-rho-kinase-inhibitors-for-retinal-detachment
#13
Ellen Townes-Anderson, Ilene Sugino, Marco Zarbin
No abstract text is available yet for this article.
July 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28715224/observation-and-identifcation-of-a-new-oh-stretch-vibrational-band-at-the-surface-of-ice
#14
Wilbert J Smit, Fujie Tang, Yuki Nagata, M Alejandra Sanchez, Taisuke Hasegawa, Ellen H G Backus, Mischa Bonn, Huib J Bakker
We study the signatures of the OH stretch vibrations at the basal surface of ice using heterodyne-detected sum-frequency generation and molecular dynamics simulations. At 150 K, we observe 7 distinct modes in the sum-frequency response, five of which have an analogue in the bulk, and two pure surface-specific modes can be identified at higher frequencies (~3530 and ~3700 cm(-1)). The band at ~3530 cm(-1) has not been reported previously. Using molecular dynamics simulations we find that the ~3530 cm(-1) band contains contributions from OH stretch vibrations of both fully coordinated interfacial water molecules and of water molecules with two donor and one acceptor hydrogen-bond...
July 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28715118/microrna159-targeted-slgamyb-transcription-factors-are-required-for-fruit-set-in-tomato
#15
Eder Marques da Silva, Geraldo Felipe Ferreira E Silva, Débora Brussolo Bidoia, Mariana da Silva Azevedo, Frederico Almeida de Jesus, Lilian Ellen Pino, Lázaro Eustáquio Pereira Peres, Esther Carrera, Isabel López-Díaz, Fabio Tebaldi Silveira Nogueira
The transition from flowering to fruit production, namely fruit set, is crucial to ensure successful sexual plant reproduction. Although studies have described the importance of hormones (i.e., auxin and gibberelins) in controlling fruit set after pollination and fertilization, the role of microRNA-based regulation during ovary development and fruit set is still poorly understood. Here we show that microRNA159/GAMYB1 and -2 pathway (the miR159/GAMYB1/2 module) is crucial for tomato ovule development and fruit set...
July 17, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28714814/using-time-driven-activity-based-costing-to-implement-change
#16
Ellen N Sayed, Sa'ad Laws, Basim Uthman
Academic medical libraries have responded to changes in technology, evolving professional roles, reduced budgets, and declining traditional services. Libraries that have taken a proactive role to change have seen their librarians emerge as collaborators and partners with faculty and researchers, while para-professional staff is increasingly overseeing traditional services. This article addresses shifting staff and schedules at a single-service-point information desk by using time-driven activity-based costing to determine the utilization of resources available to provide traditional library services...
July 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28714776/tissue-localization-of-glycosphingolipid-accumulation-in-a-gaucher-disease-mouse-brain-by-lc-esi-ms-ms-and-high-resolution-maldi-imaging-mass-spectrometry
#17
E Ellen Jones, Wujuan Zhang, Xueheng Zhao, Cristine Quiason, Stephanie Dale, Sheerin Shahidi-Latham, Gregory A Grabowski, Kenneth D R Setchell, Richard R Drake, Ying Sun
To better understand regional brain glycosphingolipid (GSL) accumulation in Gaucher disease (GD) and its relationship to neuropathology, a feasibility study using mass spectrometry and immunohistochemistry was conducted using brains derived from a GD mouse model (4L/PS/NA) homozygous for a mutant GCase (V394L [4L]) and expressing a prosaposin hypomorphic (PS-NA) transgene. Whole brains from GD and control animals were collected using one hemisphere for MALDI FTICR IMS analysis and the other for quantitation by LC-ESI-MS/MS...
July 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28713757/epidermoid-cyst-clinical-and-surgical-case-report
#18
Jose Carlos Garcia de Mendonça, Ellen Cristina Gaetti Jardim, Cauê Monteiro Dos Santos, Danilo Chizzolini Masocatto, Diones Calado de Quadros, Murilo Moura Oliveira, Juliana Andrade Macena, Fernando Ribeiro Teixeira
The epidermoid cyst is a development cyst, skin, filled with keratin and imprisoned by stratified squamous epithelium similar to skin. They are more frequent in males. Clinically presenting as flabby, prevalent over the face, neck and back. They are usually asymptomatic and its etiology is directly linked to trauma, as well as the imprisonment of epithelial rests during embryonic fusion. This study aims to present a case report of a patient 54 years old, with an epidermal cyst in the face, which was treated surgically...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713334/quantification-of-salmonella-survival-and-infection-in-an-in-vitro-model-of-the-human-intestinal-tract-as-proxy-for-foodborne-pathogens
#19
Lucas M Wijnands, Peter F M Teunis, Angelina F A Kuijpers, Ellen H M Delfgou-Van Asch, Annemarie Pielaat
Different techniques are available for assessing differences in virulence of bacterial foodborne pathogens. The use of animal models or human volunteers is not expedient for various reasons; the use of epidemiological data is often hampered by lack of crucial data. In this paper, we describe a static, sequential gastrointestinal tract (GIT) model system in which foodborne pathogens are exposed to simulated gastric and intestinal contents of the human digestive tract, including the interaction of pathogens with the intestinal epithelium...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28713237/behavioral-and-neural-correlates-of-executive-function-interplay-between-inhibition-and-updating-processes
#20
Na Young Kim, Ellen Wittenberg, Chang S Nam
This study investigated the interaction between two executive function processes, inhibition and updating, through analyses of behavioral, neurophysiological, and effective connectivity metrics. Although, many studies have focused on behavioral effects of executive function processes individually, few studies have examined the dynamic causal interactions between these two functions. A total of twenty participants from a local university performed a dual task combing flanker and n-back experimental paradigms, and completed the Operation Span Task designed to measure working memory capacity...
2017: Frontiers in Neuroscience
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