Olcay Ergurhan Kıroğlu, Fatma Aydinoglu, Nuran Oğülener
BACKGROUND: The aim of this study was to investigate whether thiols are involved in the nitrergic neurotransmission in mouse duodenum. METHODS: The effects of thiol-modulating agents, ethacrynic acid (100 μM), a non-specific sulfhydryl alkylator, and diamide (100 μM), an alkylating agent that oxidizes protein sulfhydryl groups and depletes intracellular glutathione, on relaxations to nitrergic stimulation (electrical field stimulation, EFS;10 Hz, 25 V, 1 ms, 15 s-train), S-nitrosoglutathione (GSNO; 5 μM), S-nitroso-acetylpenicillamine (SNAP; 5 μM), and S-nitrosocysteine (CysNO; 10 μM) were investigated...
2013: Journal of Basic and Clinical Physiology and Pharmacology