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https://www.readbyqxmd.com/read/28213941/population-pharmacokinetic-and-exposure-simulation-analysis-for-cediranib-azd2171-in-pooled-phase-i-ii-studies-in-patients-with-cancer
#1
Jianguo Li, Nidal Al-Huniti, Anja Henningsson, Weifeng Tang, Eric Masson
AIMS: A population pharmacokinetic (PPK) model was developed for cediranib to simulate cediranib exposure for different doses, including co-medication with strong UGT/Pgp inducers such as rifampicin, in cancer patients. METHODS: Plasma concentrations and covariates from 625 cancer patients after single or multiple oral cediranib administrations ranging from 0.5 to 90 mg in 19 Phase I and II studies were included in the analysis. Stepwise covariate modelling was used to develop the PPK model...
February 18, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28213199/cardiovascular-risk-in-different-obesity-phenotypes-over-a-decade-follow-up-tehran-lipid-and-glucose-study
#2
Bita Mirzaei, Hengameh Abdi, Sara Serahati, Maryam Barzin, Mahtab Niroomand, Fereidoun Azizi, Farhad Hosseinpanah
BACKGROUND AND AIMS: Considering the inconsistent data available on cardiovascular (CV) risk of different obesity phenotypes, the aim of this study was to investigate the development of cardiovascular disease (CVD) in different obesity phenotypes over a median follow-up of 12 years. METHODS: In this large population-based cohort, 7842 participants (44.8% men), aged ≥ 30 years, were enrolled. Participants were divided into six phenotypes based on body mass index and metabolic status...
February 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28212973/the-burden-of-obesity-on-diabetes-in-the-united-states-medical-expenditure-panel-survey-2008-to-2012
#3
Man Yee Mallory Leung, Nils P Carlsson, Graham A Colditz, Su-Hsin Chang
BACKGROUND: Diabetes is one of the most prevalent and costly chronic diseases in the United States. OBJECTIVES: To analyze the risk of developing diabetes and the annual cost of diabetes for a US general population. METHODS: Data from the Medical Expenditure Panel Survey, 2008 to 2012, were used to analyze 1) probabilities of developing diabetes and 2) annual total health care expenditures for diabetics. The age-, sex-, race-, and body mass index (BMI)-specific risks of developing diabetes were estimated by fitting an exponential survival function to age at first diabetes diagnosis...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212898/low-serum-iron-is-associated-with-high-serum-intact-fgf23-in-elderly-men-the-swedish-mros-study
#4
Catharina Lewerin, Östen Ljunggren, Herman Nilsson-Ehle, Magnus K Karlsson, Hans Herlitz, Mattias Lorentzon, Claes Ohlsson, Dan Mellström
BACKGROUND: Fibroblast growth factor (FGF23) is a protein that is produced by osteoblasts and osteocytes. Increased serum levels of FGF23 have been associated with increased risks of osteoporotic fractures and cardiovascular disease, particularly in participants with poor renal function. Serum iron (Fe) has been suggested as a regulator of FGF23 homeostasis. OBJECTIVE: To determine whether Fe and iron status are determinants of the levels of intact FGF23 (iFGF23) in elderly men...
February 14, 2017: Bone
https://www.readbyqxmd.com/read/28212894/exogenous-thyroid-hormones-regulate-the-activity-of-citrate-synthase-and-cytochrome-c-oxidase-in-warm-but-not-cold-acclimated-lake-whitefish-coregonus-clupeaformis
#5
Megan A Zak, Amy M Regish, Stephen D McCormick, Richard G Manzon
Thermal acclimation is known to elicit metabolic adjustments in ectotherms, but the cellular mechanisms and endocrine control of these shifts have not been fully elucidated. Here we examined the relationship between thermal acclimation, thyroid hormones and oxidative metabolism in juvenile lake whitefish. Impacts of thermal acclimation above (19 °C) or below (8 °C) the thermal optimum (13 °C) and exposure to exogenous thyroid hormone (60 µg T4/g body weight) were assessed by quantifying citrate synthase and cytochrome c oxidase activities in liver, red muscle, white muscle and heart...
February 14, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28212827/longitudinal-associations-between-maternal-feeding-and-overweight-in-low-income-toddlers
#6
Julie C Lumeng, Niko Kaciroti, Lauren Retzloff, Katherine Rosenblum, Alison L Miller
Maternal feeding is a frequent intervention target for the prevention of early childhood obesity but longitudinal associations between feeding and child overweight are poorly understood. This observational cohort study sought to examine the cross-lagged associations between maternal feeding and overweight across ages 21, 27, and 33 months. Feeding was measured by maternal self-report (n = 222) at each age. Child weight and length were measured. Cross-lagged analysis was used to evaluate longitudinal associations between feeding and overweight, adjusting for infant birth weight, maternal body mass index, maternal education, and maternal depressive symptoms...
February 14, 2017: Appetite
https://www.readbyqxmd.com/read/28212534/association-between-echocardiographic-structural-parameters-and-body-weight-in-wistar-rats
#7
Silvio A Oliveira-Junior, Paula F Martinez, William Y C Fan, Bruno T Nakatani, Luana U Pagan, Carlos R Padovani, Antonio C Cicogna, Marina P Okoshi, Katashi Okoshi
BACKGROUND: The association between echocardiographic structural parameters and body weight (BW) during rat development has been poorly addressed. We evaluated echocardiographic variables: left ventricular (LV) end-diastolic (LVDD) and end-systolic (LVSD) diameters, LV diastolic posterior wall thickness (PWT), left atrial diameter (LA), and aortic diameter (AO) in function of BW during development.Results/Materials and Methods: Male Wistar rats (n = 328, BW: 302-702 g) were retrospectively used to construct regression models and 95% confidence intervals relating to cardiac structural parameters and BW...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212108/the-association-between-pre-pregnancy-obesity-and-screening-results-of-depression-for-all-trimesters-of-pregnancy-postpartum-and-1-year-after-birth-a-cohort-study
#8
Hanieh Salehi-Pourmehr, Sakineh Mohammad-Alizadeh, Nayyer Jafarilar-Agdam, Somayyeh Rafiee, Azizeh Farshbaf-Khalili
OBJECTIVE: To determine the relationship between pre-pregnancy obesity and screening results of gestational and post-delivery depression in women referred to the health centers of Tabriz, Iran. METHODS: In this cohort study, 62 and 245 pregnant women with class 2-3 obesity [body mass index (BMI)≥35 kg/m2] and normal-weight (BMI 18.5-24.9 kg/m2) were enrolled, respectively, in the first trimester of pregnancy from December 2012 to January 2016. For matching of groups, nulliparous and multiparous mothers aged 18-35 years were selected with the ratio of 1:4 in obese and normal BMI groups from the same recruitment center and to controlling the confounder factors, inclusion criteria were considered...
February 17, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28210985/lumbar-disc-degeneration-was-not-related-to-spine-and-hip-bone-mineral-densities-in-chinese-facet-joint-osteoarthritis-may-confound-the-association
#9
Jianjiang Pan, Xuan Lu, Ge Yang, Yongmei Han, Xiang Tong, Yue Wang
: A sample of 512 Chinese was studied and we observed that greater disc degeneration on MRI was associated with greater spine DXA BMD. Yet, this association may be confounded by facet joint osteoarthritis. BMD may not be a risk factor for lumbar disc degeneration in Chinese. PURPOSE: Evidence suggested that lumbar vertebral bone and intervertebral disc interact with each other in multiple ways. The current paper aims to determine the association between bone mineral density (BMD) and lumbar disc degeneration using a sample of Chinese...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28209304/prognostic-value-of-the-nutritional-risk-index-in-heart-transplant-recipients
#10
Eduardo Barge-Caballero, Fernando García-López, Raquel Marzoa-Rivas, Gonzalo Barge-Caballero, David Couto-Mallón, María J Paniagua-Martín, Miguel Solla-Buceta, Carlos Velasco-Sierra, Francisco Pita-Gutiérrez, José M Herrera-Noreña, José J Cuenca-Castillo, José Manuel Vázquez-Rodríguez, María G Crespo-Leiro
INTRODUCTION AND OBJECTIVES: To study the prognostic impact of preoperative nutritional status, as assessed through the nutritional risk index (NRI), on postoperative outcomes after heart transplantation (HT). METHODS: We conducted a retrospective, single-center study of 574 patients who underwent HT from 1991 to 2014. Preoperative NRI was calculated as 1.519 × serum albumin (g/L) + 41.7 × (body weight [kg] / ideal body weight [kg]). The association between preoperative NRI and postoperative outcomes was analyzed by means of multivariable logistic regression and multivariable Cox regression...
February 10, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28209264/patient-travel-for-bariatric-surgery-does-distance-matter
#11
J Hunter Mehaffey, Alex D Michaels, Mathew G Mullen, Max O Meneveau, John R Pender, Peter T Hallowell
BACKGROUND: Increasingly, patients are faced with greater travel distances to undergo bariatric surgery at high-volume centers. OBJECTIVES: This study sought to evaluate the impact of travel distance on access to care and outcomes after bariatric surgery. SETTING: Patients who underwent Roux-en-Y gastric bypass at an academic bariatric surgery center from 1985 to 2004 were examined and stratified by patient travel distance. METHODS: Univariate analyses were performed for preoperative risk factors, 30-day complications, and long-term (10-yr) weight loss between "local," defined as<1 hour of travel time, and "regional," defined as>1 hour of travel time...
December 28, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28207613/vagal-regulation-of-cardiac-function-in-early-childhood-and-cardiovascular-risk-in-adolescence
#12
Meghan J Gangel, Lilly Shanahan, Jacek Kolacz, James A Janssen, Ashley Brown, Susan D Calkins, Susan P Keane, Laurie Wideman
OBJECTIVE: Poor behavioral self-regulation in the first two decades of life has been identified as an important precursor of disease risk in adulthood. However, physiological regulation has not been well-studied as a disease risk factor before adulthood. We tested whether physiological regulation at age two, in the form of vagal regulation of cardiac function (indexed by RSA change), would predict three indicators of cardiovascular risk at age 16 (diastolic and systolic blood pressure and body mass index)...
February 15, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28205333/longitudinal-study-of-clinical-prognostic-factors-in-patients-with-early-rheumatoid-arthritis-the-predict-study
#13
Paul Bird, Dave Nicholls, Rina Barrett, Julien de Jager, Hedley Griffiths, Lynden Roberts, Kathleen Tymms, Philip McCloud, Geoffrey Littlejohn
AIM: To assess the association between baseline clinical prognostic factors and subsequent Disease Activity Score of 28 joints (DAS28) remission in early rheumatoid arthritis (RA). METHODS: Data were collected using point of care clinical software from participating rheumatology centres. Patients aged 18 years or over whose date of clinical onset of RA was within the previous 12-24 months, who had at least 6 months of follow-up data and a DAS28-ESR (erythrocyte sedimentation rate) score recorded between 12 and 24 months from first being seen for RA were included...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28199805/bariatric-surgery-versus-intensive-medical-therapy-for-diabetes-5-year-outcomes
#14
Philip R Schauer, Deepak L Bhatt, John P Kirwan, Kathy Wolski, Ali Aminian, Stacy A Brethauer, Sankar D Navaneethan, Rishi P Singh, Claire E Pothier, Steven E Nissen, Sangeeta R Kashyap
Background Long-term results from randomized, controlled trials that compare medical therapy with surgical therapy in patients with type 2 diabetes are limited. Methods We assessed outcomes 5 years after 150 patients who had type 2 diabetes and a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 27 to 43 were randomly assigned to receive intensive medical therapy alone or intensive medical therapy plus Roux-en-Y gastric bypass or sleeve gastrectomy. The primary outcome was a glycated hemoglobin level of 6...
16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28199739/obesity-in-children-with-congenital-adrenal-hyperplasia-in-the-minnesota-cohort-importance-of-adjusting-body-mass-index-for-height-age
#15
Kyriakie Sarafoglou, Gregory P Forlenza, O Yaw Addo, Jennifer Kyllo, Aida Lteif, P C Hindmarsh, Anna Petryk, Maria Teresa Gonzalez-Bolanos, Bradley S Miller, William Thomas
OBJECTIVES: To evaluate obesity and overweight in children with congenital adrenal hyperplasia (CAH), and associations with glucocorticoids, fludrocortisone and disease control. Adjusting body mass index for-height-age (BMIHA ) percentile is proposed to correct misclassification of obese/overweight status in CAH children with advanced bone age and tall-for-age stature. DESIGN: Longitudinal. PATIENTS: 194 children with CAH seen from 1970-2013: 124 salt-wasting (SW); 70 simple-virilizing (SV); 102 females...
February 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28195643/clinical-and-genetic-predictors-of-weight-gain-in-patients-diagnosed-with-breast-cancer
#16
Maureen Sadim, Yanfei Xu, Katharina Selig, Julie Paulus, Regina Uthe, Surbhi Agarwl, Iram Dubin, Panagiota Oikonomopoulou, Lesya Zaichenko, Silvia Aki McCandlish, Linda Van Horn, Christos Mantzoros, Donna Pauler Ankerst, Virginia G Kaklamani
BACKGROUND: Postdiagnosis weight gain in patients with breast cancer has been associated with increased cancer recurrence and mortality. This study was designed to identify risk factors for weight gain and create a predictive model to identify a high-risk population for targeted interventions. METHODS: The weight of 393 patients with breast cancer from the Northwestern Robert H. Lurie Cancer Center was measured over a 2-year period from diagnosis, with body mass index (BMI) change over 18 months as the primary endpoint...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28194341/variables-influencing-the-depth-of-conscious-sedation-in-plastic-surgery-a-prospective-study
#17
Hyeonjung Yeo, Wonwoo Kim, Hyochun Park, Hoonnam Kim
BACKGROUND: Conscious sedation has been widely utilized in plastic surgery. However, inadequate research has been published evaluating adequate drug dosage and depth of sedation. In clinical practice, sedation is often inadequate or accompanied by complications when sedatives are administered according to body weight alone. The purpose of this study was to identify variables influencing the depth of sedation during conscious sedation for plastic surgery. METHODS: This prospective study evaluated 97 patients who underwent plastic surgical procedures under conscious sedation...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28193296/comparison-between-clinical-significance-of-height-adjusted-and-weight-adjusted-appendicular-skeletal-muscle-mass
#18
Taishi Furushima, Motohiko Miyachi, Motoyuki Iemitsu, Haruka Murakami, Hiroshi Kawano, Yuko Gando, Ryoko Kawakami, Kiyoshi Sanada
BACKGROUND: This study aimed to compare relationships between height- or weight-adjusted appendicular skeletal muscle mass (ASM/Ht(2) or ASM/Wt) and risk factors for cardiometabolic diseases or osteoporosis in Japanese men and women. METHODS: Subjects were healthy Japanese men (n = 583) and women (n = 1218). The study population included a young group (310 men and 357 women; age, 18-40 years) and a middle-aged and elderly group (273 men and 861 women; age, ≥41 years)...
February 13, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28188606/costs-of-productivity-loss-due-to-occupational-cancer-in-canada-estimation-using-claims-data-from-workers-compensation-boards
#19
W Dominika Wranik, Adam Muir, Min Hu
INTRODUCTION: Cancer is a leading cause of illness globally, yet our understanding of the financial implications of cancer caused by working conditions and environments is limited. The goal of this study is to estimate the costs of productivity losses due to occupational cancer in Canada, and to evaluate the factors associated with these costs. METHODS: Two sources of data are used: (i) Individual level administrative claims data from the Workers Compensation Board of Nova Scotia; and (ii) provincial aggregated cancer claims statistics from the Association of Workers Compensation Boards of Canada...
December 2017: Health Economics Review
https://www.readbyqxmd.com/read/28188053/exposure-of-portuguese-children-to-the-novel-non-phthalate-plasticizer-di-iso-nonyl-cyclohexane-1-2-dicarboxylate-dinch
#20
Luísa Correia-Sá, André Schütze, Sónia Norberto, Conceição Calhau, Valentina F Domingues, Holger M Koch
Di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH) is used as substitute for high molecular weight phthalate plasticizers such as di-(2-ethylhexyl) phthalate (DEHP) and di-(iso-nonyl) phthalate (DINP). Due to a rapid substitution process, we must assume omnipresent and increasing DINCH exposures. The aim of this study was to evaluate DINCH exposure in 112 children (4-18years old) from Portugal, divided in two groups: 1) normal-/underweight following the usual diet; and 2) obese/overweight but under strict nutritional guidance...
February 7, 2017: Environment International
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