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https://www.readbyqxmd.com/read/28549560/sensorimotor-adaptation-of-whole-body-postural-control
#1
Douglas M Shiller, Louis-Nicolas Veilleux, Mikaël Marois, Laurent Ballaz, Martin Lemay
The aim of the present study was to examine the modification of postural symmetry during quiet standing using a sensorimotor adaptation paradigm. A group of neurologically typical adult participants performed a visually-guided mediolateral (left-right) weight shifting task requiring precise adjustments in body orientation. During one phase of the task, the visual feedback of center of pressure (COP) was systematically biased toward the left or the right, requiring an adjustment in posture to compensate. COP during quiet standing without visual feedback was examined prior to and immediately following the sensorimotor adaptation procedure, in order to observe whether compensatory adjustments in postural control resulting from the visual-feedback manipulation would transfer to the control of whole-body COP during quiet standing...
May 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28548605/changes-to-the-septo-fornical-area-might-play-a-role-in-the-pathogenesis-of-anxiety-in-multiple-sclerosis
#2
Miklos Palotai, Andrea Mike, Michele Cavallari, Erzsebet Strammer, Gergely Orsi, Brian C Healy, Katharina Schregel, Zsolt Illes, Charles Rg Guttmann
BACKGROUND: Reports on the relationships between white matter lesion load (WMLL) and fatigue and anxiety in multiple sclerosis (MS) are inconsistent. OBJECTIVE: To investigate the association of total and tract-specific WMLL with fatigue and anxiety. METHODS: Total and regional T2 WMLL was assessed for 19 tracts in 48 MS patients (30 females). ICBM-DTI-81 Atlas-based parcellation was combined with WMLL segmentation of T2-weighted magnetic resonance imaging (MRI)...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28547206/glycemic-variability-in-type-1-diabetes-compared-with-degludec-and-glargine-on-the-morning-injection-an-open-label-randomized-controlled-trial
#3
Ryo Iga, Hiroshi Uchino, Ken Kanazawa, Shuki Usui, Masahiko Miyagi, Naoki Kumashiro, Hiroshi Yoshino, Yasuyo Ando, Takahisa Hirose
INTRODUCTION: Optimal adjustment of basal insulin to overcome hypoglycemia and glycemic variability (GV) depends on its duration of action and peak-less profile. Owing to the ability of long-acting basal insulin to avoid hypoglycemia, we titrated pre-meal glucose to normal fasting blood glucose, 80-110 mg/dL (4.5-6.1 mmol/L), and post-meal glucose to 80-140 mg/dL (4.5-7.8 mmol/L). The purpose of this study was to evaluate two basal insulin analogues degludec (IDeg) and glargine (IGlar), injected in the morning, for GV using continuous glucose monitoring (CGM) in type 1 diabetes (T1DM)...
May 25, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28545081/perturbed-adipose-tissue-hydrogen-peroxide-metabolism-in-centrally-obese-men-association-with-insulin-resistance
#4
May G Akl, Eman Fawzy, Maha Deif, Ayman Farouk, Amany K Elshorbagy
OBJECTIVE: Although adipose tissue hydrogen peroxide (H2O2) and its metabolizing enzymes have been linked to obesity and insulin resistance in animal studies, this relation remains to be evaluated in humans. METHODS: Non-diabetic men (N = 43, median age, 49 (37, 54 y)) undergoing abdominal surgeries were studied. Participants were classified by body mass index (BMI) into normal-weight (N = 19), or overweight/obese (Ow/Ob; BMI ≥25; N = 24). Centrally obese men were identified by waist-height ratio ≥0...
2017: PloS One
https://www.readbyqxmd.com/read/28544947/measuring-cortical-motor-hemodynamics-during-assisted-stepping-an-fnirs-feasibility-study-of-using-a-walker
#5
Andrea Cristina de Lima-Pardini, Guilherme A Zimeo Morais, Joana Bisol Balardin, Daniel Boari Coelho, Nametala Maia Azzi, Luis Augusto Teixeira, João Ricardo Sato
Walkers are commonly prescribed worldwide to individuals unable to walk independently. Walker usage leads to improved postural control and voluntary movement during step. In the present study, we aimed to provide a concept-proof on the feasibility of an event-related protocol integrating the analyses of biomechanical variables of step initiation and functional near-infrared spectroscopy (fNIRS) to measure activation of the supplementary motor area (SMA) while using a walker. Healthy young participants were tested while stepping with versus without the use of the walker...
May 17, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28544740/interannual-study-of-spot-urine-evaluated-sodium-excretion-in-young-japanese-women
#6
Kenichiro Yasutake, Ririko Moriguchi, Tomomi Kajiyama, Hitomi Miyazaki, Shimako Abe, Takashi Masuda, Katsumi Imai, Masako Iwamoto, Hiroko Tsuda, Masayo Obe, Hisaya Kawate, Hiromi Ueno, Misaki Ono, Ryoko Goromaru, Kenji Ohe, Munechika Enjoji, Takuya Tsuchihashi, Shuji Nakano
The authors investigated interannual differences in the sodium excretion levels of young healthy Japanese women as estimated from spot urine analysis at Nakamura Gakuen University from 1995 to 2015. Participants included 4931 women aged 18 to 20 years who were classified into three time periods according to year of health check: first (1995-2001), second (2002-2007), and third (2008-2015). Estimated daily urinary sodium and potassium excretion levels and the sodium to potassium ratio were 120.6±31.9 mmol, 35...
May 23, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28544548/assessment-of-factors-determining-an-hba1c-concentration%C3%A2-%C3%A2-%C3%A2-7-5-in-patients-with-type-1-diabetes
#7
Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire Bastie, Yuko Tagaya, Aya Osaki, Yoko Shimoda, Ryo Shibusawa, Tsugumichi Saito, Atsushi Ozawa, Masanobu Yamada
BACKGROUND: Establishing an optimal insulin regimen is crucial for maintaining glycemic control in patients with type 1 diabetes. We aimed to determine the insulin dose required to achieve a hemoglobin A1c (HbA1c) concentration ≤ 7.5% in Japanese patients with type 1 diabetes. METHODS: This multi-centered cross-sectional study was performed at 3 institutions in Japan. Among 107 patients with type 1 diabetes, 92 had no detectable endogenous insulin secretion: 39 patients had HbA1c concentration ≤ 7...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28544465/correlates-of-nocturia-and-relationships-of-nocturia-with-sleep-quality-and-glycemic-control-in-women-with-type-2-diabetes
#8
Chun-Jen Chang, Dee Pei, Chien-Chih Wu, Mary H Palmer, Ching-Chieh Su, Shu-Fen Kuo, Yuan-Mei Liao
PURPOSES: To explore correlates of nocturia, compare sleep quality and glycemic control for women with and without nocturia, and examine relationships of nocturia with sleep quality and glycemic control in women with diabetes. DESIGN: This study was a cross-sectional, correlational study with data collected from 275 women with type 2 diabetes. METHODS: Data were collected using a structured questionnaire. Multivariate logistic regression analyses were used to identify correlates...
May 23, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28542467/genetic-variations-in-sterol-regulatory-element-binding-protein-cleavage-activating-protein-scap-are-associated-with-blood-pressure-in-overweight-obese-chinese-children
#9
Yi-De Yang, Jie-Yun Song, Shuo Wang, Fang-Hong Liu, Yi-Ning Zhang, Xiao-Rui Shang, Hai-Jun Wang, Jun Ma
OBJECTIVE: Previous studies demonstrated a role of variations in sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) in obesity and blood lipids. But the associations between SCAP polymorphisms and blood pressure (BP) are not clear. This study aimed to investigate the relationship between genetic variations in SCAP and BP phenotypes in a Chinese pediatric population. METHODS: A case-control study on 702 high blood pressure (HBP) children and 1319 controls was conducted to explore the correlation between single nucleotide polymorphism markers (rs12487736 and rs12490383) of SCAP and BP phenotypes...
2017: PloS One
https://www.readbyqxmd.com/read/28542399/cost-effectiveness-of-a-school-based-health-promotion-program-in-canada-a-life-course-modeling-approach
#10
John Paul Ekwaru, Arto Ohinmaa, Bach Xuan Tran, Solmaz Setayeshgar, Jeffrey A Johnson, Paul J Veugelers
BACKGROUND: The Alberta Project Promoting active Living and healthy Eating in Schools (APPLE Schools) has been recognized as a "best practice" in preventing childhood obesity. To inform decision making on the economic implications of APPLE Schools and to justify investment, we evaluated the project's cost-effectiveness following a life-course approach. METHODS: We developed a state transition model for the lifetime progression of body weight status comparing elementary school students attending APPLE Schools and control schools...
2017: PloS One
https://www.readbyqxmd.com/read/28540640/a-population-pharmacokinetic-and-pharmacodynamic-analysis-of-abemaciclib-in-a-phase-i-clinical-trial-in-cancer-patients
#11
Sonya C Tate, Amanda K Sykes, Palaniappan Kulanthaivel, Edward M Chan, P Kellie Turner, Damien M Cronier
BACKGROUND AND OBJECTIVES: Abemaciclib, a dual inhibitor of cyclin-dependent kinases 4 and 6, has demonstrated clinical activity in a number of different cancer types. The objectives of this study were to characterize the pharmacokinetics of abemaciclib in cancer patients using population pharmacokinetic (popPK) modeling, and to evaluate target engagement at clinically relevant dose levels. METHODS: A phase I study was conducted in cancer patients which incorporated intensive pharmacokinetic sampling after single and multiple oral doses of abemaciclib...
May 24, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28539979/association-of-metabolic-syndrome-and-electrocardiographic-markers-of-subclinical-cardiovascular-disease
#12
Theodora W Elffers, Renée de Mutsert, Hildo J Lamb, Arie C Maan, Peter W Macfarlane, Ko Willems van Dijk, Frits R Rosendaal, J Wouter Jukema, Stella Trompet
BACKGROUND: The metabolic syndrome (MetS) and its components are well-established risk factors for cardiovascular diseases (CVD). It is inconclusive whether MetS and MetS score are associated with electrocardiographic markers of subclinical CVD, therefore we investigated this in a population without pre-existing CVD. METHODS: We performed a cross-sectional analysis in the Netherlands Epidemiology of Obesity study, a population-based cohort including 6671 participants aged 45-65...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28539380/sarcopenic-obesity-weight-loss-and-mortality-the-english-longitudinal-study-of-ageing
#13
Mark Hamer, Gary O'Donovan
Background: Age-related sarcopenia describes the loss of muscle strength and often accompanies an increase in adiposity in the elderly.Objective: We examined the association of sarcopenic obesity and changes in muscle strength and weight with the risk of mortality.Design: Participants (n = 6864) were community-dwelling men and women (45.6% men; 54.4% women; mean ± SD age: 66.2 ± 9.5 y) from the English Longitudinal Study of Ageing. Handgrip strength and body mass index (BMI; in kg/m(2)) were measured at baseline and at a 4-y follow-up...
May 24, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28538421/malnutrition-is-associated-with-hiv-infection-in-children-less-than-5-years-in-bobo-dioulasso-city-burkina-faso-a-case-control-study
#14
Ghislain Gnimbar Poda, Chien-Yeh Hsu, Jane C-J Chao
Pediatric human immunodeficiency virus (HIV) infection and malnutrition are still 2 major health issues in sub-Saharan Africa including Burkina Faso where few studies have been conducted on child malnutrition and HIV infection. This study assessed the effects of antiretroviral therapy (ART) in HIV infection and also compared the prevalence of malnutrition in terms of an inadequate diet, underweight, stunting, and wasting among HIV-infected and uninfected children less than 5 years in Bobo-Dioulasso city, Burkina Faso...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538134/trial-of-cannabidiol-for-drug-resistant-seizures-in-the-dravet-syndrome
#15
Orrin Devinsky, J Helen Cross, Linda Laux, Eric Marsh, Ian Miller, Rima Nabbout, Ingrid E Scheffer, Elizabeth A Thiele, Stephen Wright
BACKGROUND: The Dravet syndrome is a complex childhood epilepsy disorder that is associated with drug-resistant seizures and a high mortality rate. We studied cannabidiol for the treatment of drug-resistant seizures in the Dravet syndrome. METHODS: In this double-blind, placebo-controlled trial, we randomly assigned 120 children and young adults with the Dravet syndrome and drug-resistant seizures to receive either cannabidiol oral solution at a dose of 20 mg per kilogram of body weight per day or placebo, in addition to standard antiepileptic treatment...
May 25, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28537989/obesity-is-independently-associated-with-increased-risk-of-hepatocellular-cancer-related-mortality-a-systematic-review-and-meta-analysis
#16
Arjun Gupta, Avash Das, Kaustav Majumder, Nivedita Arora, Helen G Mayo, Preet P Singh, Muhammad S Beg, Siddharth Singh
OBJECTIVE: Excess body weight is associated with increased risk of developing hepatocellular cancer (HCC), but its effect on HCC-related mortality remains unclear. We performed a systematic review and meta-analysis to assess the association between premorbid obesity and HCC-related mortality. MATERIALS AND METHODS: Through a systematic literature search-up to March 2016, we identified 9 observational studies (1,599,453 individuals, 5705 HCC-related deaths) reporting the association between premorbid body mass index (BMI), and HCC-related mortality...
May 23, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28537802/seasonal-pattern-in-bipolar-disorders-and-cardio-vascular-risk-factors-a-study-from-the-face-bd-cohort
#17
Pierre A Geoffroy, Ophelia Godin, Diane Mahee, Chantal Henry, Valérie Aubin, Jean-Michel Azorin, Thierry Bougerol, Philippe Courtet, Sébastien Gard, Jean-Pierre Kahn, Christine Passerieux, Marion Leboyer, Frank Bellivier, Bruno Etain
Seasonal pattern (SP) and metabolic syndrome (MetS) are major contributors to poor outcome in bipolar disorders (BD). Patients with seasonal bipolar depression present increased appetite, carbohydrate cravings, weight gain, and hypersomnia, which can increase the development of MetS. MetS also appears to be associated with seasonal mood changes in the general population. This study examines whether a SP in BD is associated with an increased risk of MetS and its sub-components. One thousand four hundred and seventy-one outpatients with BD were systematically enrolled from 2009 to 2016...
May 24, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28537460/beyond-body-mass-index-using-anthropometric-measures-and-body-composition-indicators-to-assess-odds-of-an-endometriosis-diagnosis
#18
Uba Backonja, Mary L Hediger, Zhen Chen, Diane R Lauver, Liping Sun, C Matthew Peterson, Germaine M Buck Louis
BACKGROUND: Body mass index (BMI) and endometriosis have been inversely associated. To address gaps in this research, we examined associations among body composition, endometriosis, and physical activity. MATERIALS AND METHODS: Women from 14 clinical sites in the Salt Lake City, Utah and San Francisco, California areas and scheduled for laparoscopy/laparotomy were recruited during 2007-2009. Participants (N = 473) underwent standardized anthropometric assessments to estimate body composition before surgery...
May 24, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28537325/association-of-protein-intake-with-bone-mineral-density-and-bone-mineral-content-among-elderly-women-the-ostpre-fracture-prevention-study
#19
M Isanejad, J Sirola, J Mursu, H Kröger, M Tuppurainen, A T Erkkilä
It has been hypothesized that high protein intakes are associated with lower bone mineral content (BMC). Previous studies yield conflicting results and thus far no studies have undertaken the interaction of body mass index (BMI) and physical activity with protein intakes in relation to BMC and bone mineral density (BMD). OBJECTIVE: To evaluate the associations of dietary total protein (TP), animal protein (AP) and plant protein (PP) intakes with BMC and BMD and their changes. We tested also the interactions of protein intake with, obesity (BMI ≤30 vs...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28536936/effect-of-body-mass-index-on-clinical-outcome-and-all-cause-mortality-in-patients-undergoing-transcatheter-aortic-valve-implantation
#20
M Abawi, R Rozemeijer, P Agostoni, R C van Jaarsveld, C S van Dongen, M Voskuil, A O Kraaijeveld, P A F M Doevendans, P R Stella
OBJECTIVES: To assess the effect of body mass index (BMI) on outcome among patients with severe aortic stenosis (AS) admitted for transcatheter aortic valve implantation (TAVI). BACKGROUND: Being overweight or obese is associated with improved outcome following certain medical treatments, suggesting the existence of a BMI paradox. However, the relationship between BMI and mortality after TAVI remains controversial. METHODS: Patients were classified according to World Health Organisation criteria such as normal weight, overweight, or obesity according to their BMI (18...
May 23, 2017: Netherlands Heart Journal
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