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https://www.readbyqxmd.com/read/29902465/national-benchmarks-of-proportions-of-patients-receiving-transfusions-during-pediatric-heart-surgery
#1
Vyas M Kartha, Mohamed Rehman, Jeffrey P Jacobs, Marshall L Jacobs, David Vener, Kevin D Hill, James M Meza, Sean M O'Brien, Liqi Feng, Karen Chiswell, Neil A Goldenberg, Sara K Pasquali, Pirooz Eghtesady, Vinay Badhwar
BACKGROUND: To determine national benchmarks and assess variability across centers, the STS Congenital Heart Surgery Database (CHSD) was analyzed to document proportions of patients receiving intraoperative blood transfusion during open heart surgery. METHODS: Index CPB operations reported in the STS CHSD (2014-2015) were potentially eligible for inclusion. Data from centers with > 15% missing data for packed red blood cell (PRBC) transfusion were excluded, as were individual records missing information about PRBC transfusion...
June 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29872331/elevated-lactate-level-predicts-intensive-care-unit-admissions-endoscopies-and-transfusions-in-patients-with-acute-gastrointestinal-bleeding
#2
Manish P Shrestha, Mark Borgstrom, Eugene Abraham Trowers
Background and aims: Initial clinical management decision in patients with acute gastrointestinal bleeding (GIB) is often based on identifying high- and low-risk patients. Little is known about the role of lactate measurement in the triage of patients with acute GIB. We intended to assess if lactate on presentation is predictive of need for intervention in patients with acute GIB. Patients and methods: We performed a single-center, retrospective, cross-sectional study including patients ≥18 years old presenting to emergency with acute GIB between January 2014 and December 2014...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29862096/gastric-glomus-tumor-an-uncommon-source-for-an-acute-upper-gi-bleed
#3
Douglas Morte, Jason Bingham, Vance Sohn
Background: Glomus tumors are uncommon mesenchymal neoplasms originating from modified smooth muscle cells in the glomus body. They are generally small, solitary lesions found in the distal extremities. Rarely, involvement in the abdominal viscera can occur. In such cases, hematemesis/melena and epigastric discomfort are the most common initial symptoms. Although gastric glomus tumors can demonstrate malignant behavior, criteria for identifying malignant potential have yet to be established...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29843272/slow-enteral-feeding-decreases-risk-of-transfusion-associated-necrotizing-enterocolitis
#4
J Dako, J Buzzard, M Jain, R Pandey, S Groh-Wargo, P Shekhawat
BACKGROUND: Necrotizing Enterocolitis (NEC) is a multifactorial condition where PRBC transfusion is associated with necrotizing enterocolitis (TANEC) in about a third of all cases of NEC. We have investigated the role of feeding practices in incidence of TANEC. We sought to compare infants diagnosed with TANEC versus infants diagnosed with classic NEC and investigated the effects of a standardized slow enteral feeding (SSEF) protocol on TANEC incidence as well as the effects of SSEF on growth of infants with NEC...
May 23, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29806595/bringing-prbc-to-the-point-of-combat-injury-are-we-there-yet
#5
Aytekin Ünlü, Soner Yılmaz, Özlem Yalçın, Metin Uyanık, Patrizio Petrone, Rıza Aytaç Çetinkaya, İbrahim Eker, Murat Urkan, Taner Özgürtaş, İsmail Yaşar Avcı, Nazif Zeybek
INTRODUCTION: Hemorrhage is the leading cause of injury related pre-hospital mortality. We investigated worst case scenarios and possible requirements of Turkish Military. As we plan to use blood resources during casualty transport, the impact of transport related mechanical stress on PRBC (packed red blood cell) were analyzed. MATERIAL AND METHODS: The in vitro experiment was performed in the environmental test laboratories of ASELSAN®. Operational vibrations of potential casualty transport mediums such as Sikorsky Helicopters, Kirpi® Armoured Vehicle and NATO vibration standardsoftware MIL-STD-810G were recorded...
May 28, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29797475/clinical-value-of-jointly-detection-pleural-fluid-midkine-pleural-fluid-adenosine-deaminase-and-pleural-fluid-carbohydrate-antigen-125-in-the-identification-of-nonsmall-cell-lung-cancer-associated-malignant-pleural-effusion
#6
Fan Zhang, Junjun Wang, Xiaoyong Zheng, Lijuan Hu, Jie Chen, Feng Jiang, Yumin Wang
BACKGROUND: Midkine (MK) level has been shown to be elevated in serum of patients with nonsmall cell lung cancer (NSCLC). However, the diagnostic value of MK in pleural effusion in NSCLC has not been well validated and established. METHODS: Samples of NSCLC-associated malignant pleural effusions (MPE) and benign effusions (BPE) were collected. The pleural fluid MK (pMK), pleural fluid adenosine deaminase (pADA), pleural fluid lactate dehydrogenase (pLDH), pleural fluid glucose (pGLU), pleural fluid ferritin (pFER), pleural fluid CA199 (pCA199), pleural fluid CA125 (pCA125), pleural effusion white cell count (pWBC), and pleural effusion red cell count (pRBC) were analyzed, and the clinical data of each group were collected for statistical analysis...
May 23, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29795417/bloodless-tandem-autologous-transplant-in-jehovah-s-witness-patients
#7
Rafiullah Khan, Sarah L Mott, Allyson Schultz, Y S Jethava, Guido Tricot
Tandem autologous transplants are generally the preferred therapy for newly diagnosed intermediate- and high-risk myeloma patients. More Jehovah's Witnesses (JW) are receiving single autologous peripheral blood stem cell transplants (PBSCTs). However, tandem autologous transplants have not been reported in JW patients. We performed a retrospective study of 54 patients, including four JW patients who received tandem autologous transplants between August 2000 and January 2017 and the last 50 consecutive tandem autologous transplants performed between August 2014 and August 2016...
May 24, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29789931/relationship-between-fresh-frozen-plasma-to-packed-red-blood-cell-transfusion-ratio-and-mortality-in-cardiovascular-surgery
#8
Akito Tsukinaga, Takuma Maeda, Shunsuke Takaki, Nobuaki Michihata, Yoshihiko Ohnishi, Takahisa Goto
PURPOSE: The aim of this study was to examine the relationship between FFP (fresh frozen plasma)/pRBC (packed red blood cell) transfusion ratio and outcomes in patients undergoing cardiovascular surgery. METHODS: This is a single center retrospective cohort study performed in a cardiovascular center. Patients undergoing cardiovascular surgery between January 2012 and October 2016 with or without massive transfusion (n = 1453). Patients' outcomes were compared based on FFP/pRBC transfusion ratio (FFP/pRBC > 1 or FFP/pRBC ≤ 1)...
May 22, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29775142/aspirin-for-primary-prevention-of-stroke-in-traumatic-cerebrovascular-injury-association-with-increased-risk-of-transfusion
#9
Russell L Griffin, Stephanie R Falatko, Stella Aslibekyan, Virginia Strickland, Mark R Harrigan
OBJECTIVE Blunt traumatic extracranial carotid or vertebral artery injury (i.e., traumatic cerebrovascular injury [TCVI]) occurs in 1%-2% of all blunt trauma admissions, carries a 10% risk of thromboembolic ischemic stroke, and accounts for up to 9600 strokes annually in the US. Screening CT angiograms (CTAs) of patients with trauma has become ubiquitous in recent years, and patients with initially asymptomatic TCVI are commonly treated with antiplatelet agents to prevent stroke. Prophylaxis with antiplatelets is thought to be safer than anticoagulation, which carries a significant risk of hemorrhage in patients with trauma...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29761371/tolerability-and-efficacy-of-deferasirox-in-patients-with-transfusional-iron-overload-results-from-a-german-2-year-non-interventional-study
#10
Florian Nolte, Holger Nückel, Burkhard Schmidt, Thomas Geer, Oleg Rubanov, Holger Hebart, Andrea Jarisch, Stefan Albrecht, Christiane Johr, Christiane Schumann, Wolf-Karsten Hofmann
BACKGROUND: Iron overload (IOL) due to repetitive transfusions of packed red blood cells (pRBC) has a major impact on morbidity and mortality in patients with inherited bone marrow failure syndromes and hemoglobinopathies such as thalassemia and sickle cell disease. However, whether IOL influences the outcome of elderly patients with myeloid malignancies is not yet clear. Moreover, clinical trials have reported high drop-out rates during treatment with the oral iron chelator deferasirox (DFX)...
May 14, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29753547/an-analysis-of-casualties-presenting-to-military-emergency-departments-in-iraq-and-afghanistan
#11
Steven G Schauer, Jason F Naylor, Joshua J Oliver, Joseph K Maddry, Michael D April
BACKGROUND: During the past 17 years of conflict the deployed US military health care system has found new and innovative ways to reduce combat mortality down to the lowest case fatality rate in US history. There is currently a data dearth of emergency department (ED) care delivered in this setting. We seek to describe ED interventions in this setting. METHODS: We used a series of ED procedure codes to identify subjects within the Department of Defense Trauma Registry from January 2007 to August 2016...
May 2, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29719933/prospective-evaluation-of-the-effect-of-deferasirox-on-hematologic-response-in-transfusion-dependent-patients-with-low-risk-mds-and-iron-overload
#12
C Rose, C Lenoir, E Gyan, M Hacini, S Amé, B Corront, O Beyne-Rauzy, D Adiko, E Loppinet, N Ali-Ammar, K Laribi, E Wattel, F Dreyfus, C S Roué, S Cheze
OBJECTIVES: To assess the reduction of transfusions rate in transfusion-dependent patients with low-risk myelodysplastic syndrome (MDS) with iron overload treated with deferasirox. METHODS: Prospective observational study. Primary endpoint was reduction in transfusion requirements (RTR) at 3 months, (assessed on 8-week period). Secondary endpoints were hematologic improvement according IWG 2006 criteria at 3, 6, 12 months. RESULTS: Fifty-seven patients were evaluable...
May 2, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29714029/a-data-driven-patient-blood-management-strategy-in-liver-transplantation
#13
R A Metcalf, M B Pagano, J R Hess, J Reyes, J D Perkins, M I Montenovo
BACKGROUND AND OBJECTIVES: Blood utilization during liver transplant has decreased, but remains highly variable due to many complex surgical and physiologic factors. Previous models attempted to predict utilization using preoperative variables to stratify cases into two usage groups, usually using entire blood units for measurement. We sought to develop a practical predictive model using specific transfusion volumes (in ml) to develop a data-driven patient blood management strategy. MATERIALS AND METHODS: This is a retrospective evaluation of primary liver transplants at a single institution from 2013 to 2015...
May 1, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29706372/preoperative-anemia-versus-blood-transfusion-which-is-the-culprit-for-worse-outcomes-in-cardiac-surgery
#14
Damien J LaPar, Robert B Hawkins, Timothy L McMurry, James M Isbell, Jeffrey B Rich, Alan M Speir, Mohammed A Quader, Irving L Kron, John A Kern, Gorav Ailawadi
BACKGROUND: Reducing blood product utilization after cardiac surgery has become a focus of perioperative care as studies have suggested improved outcomes. The relative impact of preoperative anemia versus packed red blood cells (PRBC) transfusion on outcomes remains poorly understood, however. In this study, we investigated the relative association between preoperative hematocrit (Hct) level and PRBC transfusion on postoperative outcomes after coronary artery bypass grafting (CABG) surgery...
July 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29699565/in-vitro-quality-control-analysis-after-processing-and-during-storage-of-feline-packed-red-blood-cells-units
#15
C Blasi Brugué, Rui R F Ferreira, I Mesa Sanchez, Rita M C Graça, Inês M Cardoso, Augusto J F de Matos, Rafael Ruiz de Gopegui
BACKGROUND: During the storage of packed red blood cells (pRBC), packed cell volume (PCV), bacterial contamination and percentage of haemolysis [percentage of free haemoglobin (HGB) in relation to the total HGB] are important quality parameters. Both PCV and haemolysis are indicators of the cellular integrity of stored units. There are no published experimental studies that evaluated these parameters during storage of feline pRBC using SAGM (adenine, dextrose, mannitol and sodium chloride) as the additive solution...
April 27, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29669329/conventional-versus-single-port-laparoscopy-for-the-surgical-treatment-of-ectopic-pregnancy-a-meta-analysis
#16
Maria Luisa Gasparri, Michael D Mueller, Katayoun Taghavi, Andrea Papadia
BACKGROUND/AIMS: A new minimally invasive laparoscopic approach for ectopic pregnancy, the laparo-endoscopic single site surgery (LESS), has recently been introduced. The aim of this study is to compare the surgical outcome of this approach with conventional laparoscopy for ectopic pregnancy. METHOD: A review following the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement was performed. Electronic databases PubMed, MEDLINE, and Scopus were searched in December 2017 by searching the terms "single port laparoscopy" or "laparoendoscopic single site-surgery" or "single site laparoscopy" or "single-incision laparoscopic surgery" and "ectopic pregnancy...
April 17, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29664892/the-role-of-4-factor-prothrombin-complex-concentrate-4-pcc-in-coagulopathy-of-trauma-a-propensity-matched-analysis
#17
Faisal Jehan, Hassan Aziz, Terence O'Keeffe, Muhammad Khan, El Rasheid Zakaria, Mohammad Hamidi, Muhammad Zeeshan, Narong Kulvatunyou, Bellal Joseph
INTRODUCTION: Coagulopathy is a common complication after severe trauma. The efficacy of 4-factor Prothrombin Complex Concentrate (4-PCC) as an adjunct to FFP in reversal of coagulopathy of trauma has not been studied. The aim of our study is to compare 4-PCC+FFP vs. FPP alone for the treatment of COT. METHODS: We reviewed all trauma patients >18y who received PCC+FFP or FFP alone at our Level I trauma center from 2015-16. We excluded patients on preinjury oral anticoagulants...
April 16, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29573055/effect-of-cross-match-on-packed-cell-volume-after-transfusion-of-packed-red-blood-cells-in-transfusion-na%C3%A3-ve-anemic-cats
#18
Brittany Sylvane, Jennifer Prittie, Ann E Hohenhaus, Erik Tozier
BACKGROUND: Novel feline RBC antigens might contribute to decreased efficacy of RBC transfusion and increased incidence of acute transfusion reactions (ATR). OBJECTIVES: To examine the effect of major cross-match in transfusion-naïve anemic cats on the incidence of acute immunologic transfusion reaction and transfusion efficacy for up to 24 hours after transfusion. ANIMALS: Forty-eight client owned transfusion-naïve anemic cats. METHODS: Prospective, randomized, controlled study...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29567936/splenic-rupture-as-the-first-manifestation-of-babesia-microti-infection-report-of-a-case-and-review-of-literature
#19
Igor Dumic, Janki Patel, Melissa Hart, Eric R Niendorf, Scott Martin, Poornima Ramanan
BACKGROUND Babesiosis is an emerging, tick-borne zoonosis caused by intraerythrocytic protozoa of the genus Babesia. Babesia microti is the main pathogen causing human disease and is endemic in the northeastern and upper midwestern parts of the USA. Severity of infection ranges from mild, self-limited, febrile viral-like illness accompanied by nonspecific symptoms to life-threatening infection complicated by severe hemolytic anemia, disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and renal or/and hepatic failure...
March 23, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29565746/packed-red-blood-cell-transfusion-modulates-myeloid-dendritic-cell-activation-and-inflammatory-response-in-vitro
#20
Katrina K Ki, Helen M Faddy, Robert L Flower, Melinda M Dean
Transfusion of packed red blood cells (PRBCs) modulates patients' immune responses and clinical outcomes; however, the underpinning mechanism(s) remain unknown. The potential for PRBC to modulate myeloid dendritic cells (mDC) and blood DC antigen 3 was assessed using an in vitro transfusion model. In parallel, to model processes activated by viral or bacterial infection, toll-like receptor agonists polyinosinic:polycytidylic acid or lipopolysaccharide were added. Exposure to PRBC upregulated expression of CD83 and downregulated CD40 and CD80 on both DC subsets, and it suppressed production of interleukin (IL)-6, IL-8, IL-12, tumor necrosis factor-α, and interferon-gamma-inducible protein-10 by these cells...
March 2018: Journal of Interferon & Cytokine Research
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