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Schizophrenia anhedonia

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https://www.readbyqxmd.com/read/28243163/drug-abuse-and-psychosis-new-insights-into-drug-induced-psychosis
#1
REVIEW
Suji Ham, Tae Kyoo Kim, Sooyoung Chung, Heh-In Im
Addictive drug use or prescribed medicine abuse can cause psychosis. Some representative symptoms frequently elicited by patients with psychosis are hallucination, anhedonia, and disrupted executive functions. These psychoses are categorized into three classifications of symptoms: positive, negative, and cognitive. The symptoms of DIP are not different from the symptoms of schizophrenia, and it is difficult to distinguish between them. Due to this ambiguity of distinction between the DIP and schizophrenia, the DIP animal model has been frequently used as the schizophrenia animal model...
February 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/28242515/emotional-word-usage-in-groups-at-risk-for-schizophrenia-spectrum-disorders-an-objective-investigation-of-attention-to-emotion
#2
Christie K Fung, Melody M Moore, Nicole R Karcher, John G Kerns, Elizabeth A Martin
Both extreme levels of social anhedonia (SocAnh) and extreme levels of perceptual aberration/magical ideation (PerMag) indicate increased risk for schizophrenia-spectrum disorders and are associated with emotional deficits. For SocAnh, there is evidence of self-reported decreased trait positive affect and abnormalities in emotional attention. For PerMag, there is evidence of increased trait negative affect and increased attention to negative emotion. Yet, the nature of more objective emotional abnormalities in these groups is unclear...
February 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28237759/the-psychometric-validity-of-the-center-for-epidemiological-studies-depression-scale-ces-d-in-first-episode-schizophrenia-spectrum
#3
Sarah E Herniman, Kelly A Allott, Eóin Killackey, Robert Hester, Sue M Cotton
Depressive pathology is common in first-episode schizophrenia spectrum disorders (FES), and is frequently assessed using the Center for Epidemiological Studies - Depression Scale (CES-D), an instrument designed for use in community samples. Despite its widespread use, no prior study has examined the psychometric validity of the CES-D in assessing depressive pathology in FES. The aim of this study was to examine the psychometric validity of the CES-D in FES. This study involved secondary analysis of baseline data from a single blind, randomized controlled trial of vocational intervention for individuals with FES (N=91; age range: 15-25 years)...
February 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28237133/reward-processing-and-mood-related-symptoms-an-rdoc-and-translational-neuroscience-perspective
#4
REVIEW
Robin Nusslock, Lauren B Alloy
BACKGROUND: Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) mechanisms that are unique to specific psychiatric symptoms, and that reflect markers of differential risk for these symptoms. With respect to these objectives, a brain-behavior dimension that has received considerable attention and that is directly relevant to the Positive Valence Systems domain of the RDoC initiative involves reward processing...
February 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28212174/categorizing-and-assessing-negative-symptoms
#5
Paola Bucci, Silvana Galderisi
PURPOSE OF REVIEW: To provide a review on studies published in the last year relevant to the categorization and assessment of negative symptoms. RECENT FINDINGS: Recent research supported the validity of the 'deficit/non-deficit schizophrenia' categorization. Few studies confirmed the validity of the category 'persistent negative symptoms', whereas no recent study explored the validity of the category 'predominant negative symptoms'. The two-factor structure of the negative dimension is supported by studies reporting different correlates for the two subdomains: diminished expression and avolition/apathy...
February 15, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28211553/the-assessment-of-schizotypy-by-the-o-life-oxford-liverpool-inventory-for-feelings-and-experiences-in-patients-with-schizophrenia-and-affective-disorders
#6
Daria Dembińska-Krajewska, Janusz Rybakowski
OBJECTIVES: The aim of the study was to assess schizotypy by using the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE), in the groups of patients with schizophrenia, bipolar disorder (BD) and unipolar (recurrent) depression (UD). An important element of the study was to compare - in terms of similarity - the results obtained in schizophrenia and BD, and - in terms of differences - the results obtained in BD and UD. METHODS: The study involved 58 patients with schizophrenia (35 men, 23 women, mean age = 34...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28174121/an-electrophysiological-investigation-of-emotional-abnormalities-in-groups-at-risk-for-schizophrenia-spectrum-personality-disorders
#7
Elizabeth A Martin, Nicole R Karcher, Bruce D Bartholow, Greg J Siegle, John G Kerns
Both extreme levels of social anhedonia (SocAnh) and perceptual aberration/magical ideation (PerMag) are associated with risk for schizophrenia-spectrum disorders and with emotional abnormalities. Yet, the nature of any psychophysiological-measured affective abnormality, including the role of automatic/controlled processes, is unclear. We examined the late positive potential (LPP) during passive viewing (to assess automatic processing) and during cognitive reappraisal (to assess controlled processing) in three groups: SocAnh, PerMag, and controls...
March 2017: Biological Psychology
https://www.readbyqxmd.com/read/28135847/common-dimensional-reward-deficits-across-mood-and-psychotic-disorders-a-connectome-wide-association-study
#8
Anup Sharma, Daniel H Wolf, Rastko Ciric, Joseph W Kable, Tyler M Moore, Simon N Vandekar, Natalie Katchmar, Aylin Daldal, Kosha Ruparel, Christos Davatzikos, Mark A Elliott, Monica E Calkins, Russell T Shinohara, Danielle S Bassett, Theodore D Satterthwaite
OBJECTIVE: Anhedonia is central to multiple psychiatric disorders and causes substantial disability. A dimensional conceptualization posits that anhedonia severity is related to a transdiagnostic continuum of reward deficits in specific neural networks. Previous functional connectivity studies related to anhedonia have focused on case-control comparisons in specific disorders, using region-specific seed-based analyses. Here, the authors explore the entire functional connectome in relation to reward responsivity across a population of adults with heterogeneous psychopathology...
January 31, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28127915/the-current-conceptualization-of-negative-symptoms-in-schizophrenia
#9
Stephen R Marder, Silvana Galderisi
Negative symptoms have long been conceptualized as a core aspect of schizophrenia. They play a key role in the functional outcome of the disorder, and their management represents a significant unmet need. Improvements in definition, characterization, assessment instruments and experimental models are needed in order to foster research aimed at developing effective interventions. A consensus has recently been reached on the following aspects: a) five constructs should be considered as negative symptoms, i.e...
February 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28034960/elevated-dna-oxidation-and-dna-repair-enzyme-expression-in-brain-white-matter-in-major-depressive-disorder
#10
Attila Szebeni, Katalin Szebeni, Timothy P DiPeri, Luke A Johnson, Craig A Stockmeier, Jessica D Crawford, Michelle J Chandley, Liza J Hernandez, Katherine C Burgess, Russell W Brown, Gregory A Ordway
BACKGROUND: Pathology of white matter in brains of patients with major depressive disorder (MDD) is well-documented, but the cellular and molecular basis of this pathology are poorly understood. METHODS: Levels of DNA oxidation and gene expression of DNA damage repair enzymes were measured in Brodmann area 10 (BA10) and/or amygdala (uncinate fasciculus) white matter tissue from brains of MDD (n=10) and psychiatrically normal control donors (n=13). DNA oxidation was also measured in BA10 white matter of schizophrenia donors (n=10) and in prefrontal cortical white matter from control rats (n=8) and rats with repeated stress-induced anhedonia (n=8)...
December 29, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27980891/a-review-of-anticipatory-pleasure-in-schizophrenia
#11
Katherine H Frost, Gregory P Strauss
PURPOSE OF REVIEW: Anhedonia, traditionally defined as a diminished capacity to experience pleasure, has long been considered a core symptom of schizophrenia. However, recent research calls into question whether individuals with schizophrenia are truly anhedonic, suggesting intact subjective and neurophysiological response to rewarding stimuli in-the-moment. Despite a presumably intact capacity to experience pleasure, people with schizophrenia still engage in fewer reward-seeking behaviors...
September 2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/27927242/sudden-death-due-to-paralysis-and-synaptic-and-behavioral-deficits-when-hip14-zdhhc17-is-deleted-in-adult-mice
#12
Shaun S Sanders, Matthew P Parsons, Katherine K N Mui, Amber L Southwell, Sonia Franciosi, Daphne Cheung, Sabine Waltl, Lynn A Raymond, Michael R Hayden
BACKGROUND: Palmitoylation, the addition of palmitate to proteins by palmitoyl acyltransferases (PATs), is an important regulator of synaptic protein localization and function. Many palmitoylated proteins and PATs have been implicated in neuropsychiatric diseases, including Huntington disease, schizophrenia, amyotrophic lateral sclerosis, Alzheimer disease, and X-linked intellectual disability. HIP14/DHHC17 is the most conserved PAT that palmitoylates many synaptic proteins. Hip14 hypomorphic mice have behavioral and synaptic deficits...
December 7, 2016: BMC Biology
https://www.readbyqxmd.com/read/27903327/auditory-vigilance-and-working-memory-in-youth-at-familial-risk-for-schizophrenia-or-affective-psychosis-in-the-harvard-adolescent-family-high-risk-study
#13
Larry J Seidman, Andrea Pousada-Casal, Silvia Scala, Eric C Meyer, William S Stone, Heidi W Thermenos, Elena Molokotos, Jessica Agnew-Blais, Ming T Tsuang, Stephen V Faraone
BACKGROUND: The degree of overlap between schizophrenia (SCZ) and affective psychosis (AFF) has been a recurring question since Kraepelin's subdivision of the major psychoses. Studying nonpsychotic relatives allows a comparison of disorder-associated phenotypes, without potential confounds that can obscure distinctive features of the disorder. Because attention and working memory have been proposed as potential endophenotypes for SCZ and AFF, we compared these cognitive features in individuals at familial high-risk (FHR) for the disorders...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27886638/preliminary-evidence-that-negative-symptom-severity-relates-to-multilocus-genetic-profile-for-dopamine-signaling-capacity-and-d2-receptor-binding-in-healthy-controls-and-in-schizophrenia
#14
Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barch
Deficits in central, subcortical dopamine (DA) signaling may underlie negative symptom severity, particularly anhedonia, in healthy individuals and in schizophrenia. To investigate these relationships, we assessed negative symptoms with the Schedule for the Assessment of Negative Symptoms and the Brief Negative Symptom Scale (BNSS) and self-reported anhedonia with the Scales for Physical and Social Anhedonia (SPSA), Temporal Experience of Pleasure Scale, and Snaith-Hamilton Pleasure Scale in 36 healthy controls (HC), 27 siblings (SIB) of individuals with schizophrenia, and 66 individuals with schizophrenia or schizoaffective disorder (SCZ)...
March 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27876020/the-brief-negative-symptom-scale-validation-of-the-german-translation-and-convergent-validity-with-self-rated-anhedonia-and-observer-rated-apathy
#15
Martin Bischof, Caitriona Obermann, Matthias N Hartmann, Oliver M Hager, Matthias Kirschner, Agne Kluge, Gregory P Strauss, Stefan Kaiser
BACKGROUND: Negative symptoms are considered core symptoms of schizophrenia. The Brief Negative Symptom Scale (BNSS) was developed to measure this symptomatic dimension according to a current consensus definition. The present study examined the psychometric properties of the German version of the BNSS. To expand former findings on convergent validity, we employed the Temporal Experience Pleasure Scale (TEPS), a hedonic self-report that distinguishes between consummatory and anticipatory pleasure...
November 22, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27833939/probabilistic-reinforcement-learning-in-patients-with-schizophrenia-relationships-to-anhedonia-and-avolition
#16
Erin C Dowd, Michael J Frank, Anne Collins, James M Gold, Deanna M Barch
BACKGROUND: Anhedonia (a reduced experience of pleasure) and avolition (a reduction in goal-directed activity) are common features of schizophrenia that have substantial effects on functional outcome, but are poorly understood and treated. Here, we examined whether alterations in reinforcement learning may contribute to these symptoms in schizophrenia by impairing the translation of reward information into goal-directed action. METHODS: 38 stable outpatients with schizophrenia or schizoaffective disorder and 37 healthy controls underwent fMRI during a probabilistic stimulus selection reinforcement learning task with dissociated choice- and feedback-related activation, followed by a behavioral transfer task allowing separate assessment of learning from positive versus negative outcomes...
September 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/27752140/the-neural-transfer-effect-of-working-memory-training-to-enhance-hedonic-processing-in-individuals-with-social-anhedonia
#17
Xu Li, Zhi Li, Ke Li, Ya-Wei Zeng, Hai-Song Shi, Wen-Lan Xie, Zhuo-Ya Yang, Simon S Y Lui, Eric F C Cheung, Ada W S Leung, Raymond C K Chan
Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially rewarding events. It remains unclear whether non-pharmacological interventions, such as cognitive training, could improve anhedonia. The present study aimed to examine the neural mechanism for alleviating hedonic deficits with working memory (WM) training in individuals with social anhedonia...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27732031/attentional-processing-of-emotional-faces-in-schizophrenia-evidence-from-eye-tracking
#18
Seon-Kyeong Jang, Sujin Kim, Chai-Youn Kim, Hyeon-Seung Lee, Kee-Hong Choi
Severe emotional disturbances such as anxiety and depression have been closely related to aberrant attentional processing of emotional stimuli. However, this has been little studied in schizophrenia, which is also characterized by marked emotional impairments such as heightened negative affect and anhedonia. In the current study, we investigated temporal dynamics of motivated attention to emotional stimuli in schizophrenia. For this purpose, we tracked eye movements of 22 individuals with schizophrenia or schizoaffective disorder (ISZs) and 19 healthy controls (HCs) to emotional (i...
October 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27732025/-psychosis-predictive-value-of-self-reported-schizotypy-in-a-clinical-high-risk-sample-correction-to-fl%C3%A3-ckiger-et-al-2016
#19
(no author information available yet)
Reports an error in "Psychosis-Predictive Value of Self-Reported Schizotypy in a Clinical High-Risk Sample" by Rahel Flückiger, Stephan Ruhrmann, Martin Debbané, Chantal Michel, Daniela Hubl, Benno G. Schimmelmann, Joachim Klosterkötter and Frauke Schultze-Lutter (Journal of Abnormal Psychology, Advanced Online Publication, Sep 1, 2016, np). In the article, there was an error in the Author Note. The affiliation of Daniela Hubl was incorrectly listed as "University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern...
2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27699943/treatment-for-anhedonia-a-neuroscience-driven-approach
#20
Michelle G Craske, Alicia E Meuret, Thomas Ritz, Michael Treanor, Halina J Dour
Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression, some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a predictor of poor long-term outcomes, including suicide, and poor treatment response. Because extant psychological and pharmacological treatments are relatively ineffective for anhedonia, there is an unmet therapeutic need for this high-risk symptom. Current psychological and drug treatments for anxiety and depression focus largely on reducing excesses in negative affect rather than improving deficits in positive affect...
October 2016: Depression and Anxiety
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