keyword
MENU ▼
Read by QxMD icon Read
search

Schizophrenia anhedonia

keyword
https://www.readbyqxmd.com/read/28034960/elevated-dna-oxidation-and-dna-repair-enzyme-expression-in-brain-white-matter-in-major-depressive-disorder
#1
Attila Szebeni, Katalin Szebeni, Timothy P DiPeri, Luke A Johnson, Craig A Stockmeier, Jessica D Crawford, Michelle J Chandley, Liza J Hernandez, Katherine C Burgess, Russell W Brown, Gregory A Ordway
BACKGROUND: Pathology of white matter in brains of patients with major depressive disorder (MDD) is well-documented, but the cellular and molecular basis of this pathology are poorly understood. METHODS: Levels of DNA oxidation and gene expression of DNA damage repair enzymes were measured in Brodmann area 10 (BA10) and/or amygdala (uncinate fasciculus) white matter tissue from brains of MDD (n=10) and psychiatrically normal control donors (n=13). DNA oxidation was also measured in BA10 white matter of schizophrenia donors (n=10) and in prefrontal cortical white matter from control rats (n=8) and rats with repeated stress-induced anhedonia (n=8)...
December 29, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27980891/a-review-of-anticipatory-pleasure-in-schizophrenia
#2
Katherine H Frost, Gregory P Strauss
PURPOSE OF REVIEW: Anhedonia, traditionally defined as a diminished capacity to experience pleasure, has long been considered a core symptom of schizophrenia. However, recent research calls into question whether individuals with schizophrenia are truly anhedonic, suggesting intact subjective and neurophysiological response to rewarding stimuli in-the-moment. Despite a presumably intact capacity to experience pleasure, people with schizophrenia still engage in fewer reward-seeking behaviors...
September 2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/27927242/sudden-death-due-to-paralysis-and-synaptic-and-behavioral-deficits-when-hip14-zdhhc17-is-deleted-in-adult-mice
#3
Shaun S Sanders, Matthew P Parsons, Katherine K N Mui, Amber L Southwell, Sonia Franciosi, Daphne Cheung, Sabine Waltl, Lynn A Raymond, Michael R Hayden
BACKGROUND: Palmitoylation, the addition of palmitate to proteins by palmitoyl acyltransferases (PATs), is an important regulator of synaptic protein localization and function. Many palmitoylated proteins and PATs have been implicated in neuropsychiatric diseases, including Huntington disease, schizophrenia, amyotrophic lateral sclerosis, Alzheimer disease, and X-linked intellectual disability. HIP14/DHHC17 is the most conserved PAT that palmitoylates many synaptic proteins. Hip14 hypomorphic mice have behavioral and synaptic deficits...
December 7, 2016: BMC Biology
https://www.readbyqxmd.com/read/27903327/auditory-vigilance-and-working-memory-in-youth-at-familial-risk-for-schizophrenia-or-affective-psychosis-in-the-harvard-adolescent-family-high-risk-study
#4
Larry J Seidman, Andrea Pousada-Casal, Silvia Scala, Eric C Meyer, William S Stone, Heidi W Thermenos, Elena Molokotos, Jessica Agnew-Blais, Ming T Tsuang, Stephen V Faraone
BACKGROUND: The degree of overlap between schizophrenia (SCZ) and affective psychosis (AFF) has been a recurring question since Kraepelin's subdivision of the major psychoses. Studying nonpsychotic relatives allows a comparison of disorder-associated phenotypes, without potential confounds that can obscure distinctive features of the disorder. Because attention and working memory have been proposed as potential endophenotypes for SCZ and AFF, we compared these cognitive features in individuals at familial high-risk (FHR) for the disorders...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27886638/preliminary-evidence-that-negative-symptom-severity-relates-to-multilocus-genetic-profile-for-dopamine-signaling-capacity-and-d2-receptor-binding-in-healthy-controls-and-in-schizophrenia
#5
Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barch
Deficits in central, subcortical dopamine (DA) signaling may underlie negative symptom severity, particularly anhedonia, in healthy individuals and in schizophrenia. To investigate these relationships, we assessed negative symptoms with the Schedule for the Assessment of Negative Symptoms and the Brief Negative Symptom Scale (BNSS) and self-reported anhedonia with the Scales for Physical and Social Anhedonia (SPSA), Temporal Experience of Pleasure Scale, and Snaith-Hamilton Pleasure Scale in 36 healthy controls (HC), 27 siblings (SIB) of individuals with schizophrenia, and 66 individuals with schizophrenia or schizoaffective disorder (SCZ)...
November 17, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27876020/the-brief-negative-symptom-scale-validation-of-the-german-translation-and-convergent-validity-with-self-rated-anhedonia-and-observer-rated-apathy
#6
Martin Bischof, Caitriona Obermann, Matthias N Hartmann, Oliver M Hager, Matthias Kirschner, Agne Kluge, Gregory P Strauss, Stefan Kaiser
BACKGROUND: Negative symptoms are considered core symptoms of schizophrenia. The Brief Negative Symptom Scale (BNSS) was developed to measure this symptomatic dimension according to a current consensus definition. The present study examined the psychometric properties of the German version of the BNSS. To expand former findings on convergent validity, we employed the Temporal Experience Pleasure Scale (TEPS), a hedonic self-report that distinguishes between consummatory and anticipatory pleasure...
November 22, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27833939/probabilistic-reinforcement-learning-in-patients-with-schizophrenia-relationships-to-anhedonia-and-avolition
#7
Erin C Dowd, Michael J Frank, Anne Collins, James M Gold, Deanna M Barch
BACKGROUND: Anhedonia (a reduced experience of pleasure) and avolition (a reduction in goal-directed activity) are common features of schizophrenia that have substantial effects on functional outcome, but are poorly understood and treated. Here, we examined whether alterations in reinforcement learning may contribute to these symptoms in schizophrenia by impairing the translation of reward information into goal-directed action. METHODS: 38 stable outpatients with schizophrenia or schizoaffective disorder and 37 healthy controls underwent fMRI during a probabilistic stimulus selection reinforcement learning task with dissociated choice- and feedback-related activation, followed by a behavioral transfer task allowing separate assessment of learning from positive versus negative outcomes...
September 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/27752140/the-neural-transfer-effect-of-working-memory-training-to-enhance-hedonic-processing-in-individuals-with-social-anhedonia
#8
Xu Li, Zhi Li, Ke Li, Ya-Wei Zeng, Hai-Song Shi, Wen-Lan Xie, Zhuo-Ya Yang, Simon S Y Lui, Eric F C Cheung, Ada W S Leung, Raymond C K Chan
Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially rewarding events. It remains unclear whether non-pharmacological interventions, such as cognitive training, could improve anhedonia. The present study aimed to examine the neural mechanism for alleviating hedonic deficits with working memory (WM) training in individuals with social anhedonia...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27732031/attentional-processing-of-emotional-faces-in-schizophrenia-evidence-from-eye-tracking
#9
Seon-Kyeong Jang, Sujin Kim, Chai-Youn Kim, Hyeon-Seung Lee, Kee-Hong Choi
Severe emotional disturbances such as anxiety and depression have been closely related to aberrant attentional processing of emotional stimuli. However, this has been little studied in schizophrenia, which is also characterized by marked emotional impairments such as heightened negative affect and anhedonia. In the current study, we investigated temporal dynamics of motivated attention to emotional stimuli in schizophrenia. For this purpose, we tracked eye movements of 22 individuals with schizophrenia or schizoaffective disorder (ISZs) and 19 healthy controls (HCs) to emotional (i...
October 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27732025/-psychosis-predictive-value-of-self-reported-schizotypy-in-a-clinical-high-risk-sample-correction-to-fl%C3%A3-ckiger-et-al-2016
#10
(no author information available yet)
Reports an error in "Psychosis-Predictive Value of Self-Reported Schizotypy in a Clinical High-Risk Sample" by Rahel Flückiger, Stephan Ruhrmann, Martin Debbané, Chantal Michel, Daniela Hubl, Benno G. Schimmelmann, Joachim Klosterkötter and Frauke Schultze-Lutter (Journal of Abnormal Psychology, Advanced Online Publication, Sep 1, 2016, np). In the article, there was an error in the Author Note. The affiliation of Daniela Hubl was incorrectly listed as "University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern...
October 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27699943/treatment-for-anhedonia-a-neuroscience-driven-approach
#11
Michelle G Craske, Alicia E Meuret, Thomas Ritz, Michael Treanor, Halina J Dour
Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression, some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a predictor of poor long-term outcomes, including suicide, and poor treatment response. Because extant psychological and pharmacological treatments are relatively ineffective for anhedonia, there is an unmet therapeutic need for this high-risk symptom. Current psychological and drug treatments for anxiety and depression focus largely on reducing excesses in negative affect rather than improving deficits in positive affect...
October 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27683568/impaired-self-monitoring-of-inner-speech-in-schizophrenia-patients-with-verbal-hallucinations-and-in-non-clinical-individuals-prone-to-hallucinations
#12
Gildas Brébion, Christian Stephan-Otto, Susana Ochoa, Mercedes Roca, Lourdes Nieto, Judith Usall
BACKGROUND: Previous research has shown that various memory errors reflecting failure in the self-monitoring of speech were associated with auditory/verbal hallucinations in schizophrenia patients and with proneness to hallucinations in non-clinical individuals. METHOD: We administered to 57 schizophrenia patients and 60 healthy participants a verbal memory task involving free recall and recognition of lists of words with different structures (high-frequency, low-frequency, and semantically organisable words)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27639163/the-effects-of-working-memory-training-on-enhancing-hedonic-processing-to-affective-rewards-in-individuals-with-high-social-anhedonia
#13
Xu Li, Ya-Hui Xiao, Lai-Quan Zou, Huan-Huan Li, Zhuo-Ya Yang, Hai-Song Shi, Simon S Y Lui, Eric F C Cheung, Raymond C K Chan
Anhedonia is a core feature of the negative symptoms of schizophrenia and is less responsive to antipsychotic medication. Little is known whether anhedonia could be alleviated by cognitive training. The present study aimed to examine whether hedonic deficits observed in individuals with high social anhedonia could be reduced by working memory (WM) training. Thirty-four individuals with high social anhedonia were randomly assigned to either a WM training group or a control group. The WM training group received 20 sessions of dual n-back task training for four weeks...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27606313/neural-correlates-of-schizophrenia-negative-symptoms-distinct-subtypes-impact-dissociable-brain-circuits
#14
Joseph J Shaffer, Michael J Peterson, Mary Agnes McMahon, Joshua Bizzell, Vince Calhoun, Theo G M van Erp, Judith M Ford, John Lauriello, Kelvin O Lim, Dara S Manoach, Sarah C McEwen, Daniel H Mathalon, Daniel O'Leary, Steven G Potkin, Adrian Preda, Jessica Turner, Jim Voyvodic, Cynthia G Wible, Aysenil Belger
BACKGROUND: The negative symptoms of schizophrenia include deficits in emotional expression and motivation. These deficits are stable over the course of illness and respond poorly to current medications. Previous studies have focused on negative symptoms as a single category; however, individual symptoms might be related to separate neurological disturbances. We analyzed data from the Functional Biomedical Informatics Research Network dataset to explore the relationship between individual negative symptoms and functional brain activity during an auditory oddball task...
December 2015: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27583768/psychosis-predictive-value-of-self-reported-schizotypy-in-a-clinical-high-risk-sample
#15
Rahel Flückiger, Stephan Ruhrmann, Martin Debbané, Chantal Michel, Daniela Hubl, Benno G Schimmelmann, Joachim Klosterkötter, Frauke Schultze-Lutter
[Correction Notice: An Erratum for this article was reported in Vol 125(7) of Journal of Abnormal Psychology (see record 2016-47529-004). In the article, there was an error in the Author Note. The affiliation of Daniela Hubl was incorrectly listed as "University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern." It should have been listed as "University Hospital of Psychiatry and Psychotherapy, University of Bern." All versions of this article have been corrected.] Schizotypy is considered an indicator of psychosis-proneness and therefore, a precursor to schizophrenia-spectrum psychosis...
October 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27517342/coping-strategies-in-schizoaffective-disorder-and-schizophrenia-differences-and-similarities
#16
Cinzia Mingrone, Cristiana Montemagni, Luisa Sandei, Irene Bava, Irene Mancini, Simona Cardillo, Paola Rocca
Aims of the current study were to explore differences in coping between 58 patients with schizoaffective disorder (SAD) and 89 with schizophrenia (SZ) and to identify factors associated with coping in both disorders. The demographic and clinical characteristics of patients with SAD and with SZ were compared using ANOVA and χ(2). Pearson's correlations were calculated between coping styles and socio-demographic and clinical variables in each group. The significant ones were subsequently analyzed using multiple regressions...
October 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27458412/loneliness-and-schizotypy-are-distinct-constructs-separate-from-general-psychopathology
#17
Johanna C Badcock, Emma Barkus, Alex S Cohen, Romola Bucks, David R Badcock
Loneliness is common in youth and associated with a significantly increased risk of psychological disorders. Although loneliness is strongly associated with psychosis, its relationship with psychosis proneness is unclear. Our aim in this paper was to test the hypothesis that loneliness and schizotypal traits, conveying risk for schizophrenia spectrum disorders, are similar but separate constructs. Pooling data from two non-clinical student samples (N = 551) we modeled the structure of the relationship between loneliness and trait schizotypy...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27453425/individual-negative-symptoms-and-domains-relevance-for-assessment-pathomechanisms-and-treatment
#18
Stefan Kaiser, John Lyne, Ingrid Agartz, Mary Clarke, Lynn Mørch-Johnsen, Ann Faerden
The negative symptoms of schizophrenia can be divided into two domains. Avolition/apathy includes the individual symptoms of avolition, asociality and anhedonia. Diminished expression includes blunted affect and alogia. Until now, causes and treatment of negative symptoms have remained a major challenge, which is partially related to the focus on negative symptoms as a broad entity. Here, we propose that negative symptoms may become more tractable when the different domains and individual symptoms are taken into account...
July 21, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27399308/the-relationship-between-self-referential-processing-related-brain-activity-and-anhedonia-in-patients-with-schizophrenia
#19
Jung Suk Lee, Eun Seong Kim, Eun Joo Kim, Joohan Kim, Eosu Kim, Seung-Koo Lee, Jae-Jin Kim
Despite the possible relationship between impaired self-referential processing and anhedonia, it has not yet been investigated. This study investigated an abnormality in brain activation associated with self-referential processing and its relationship with anhedonia in schizophrenia, specifically in self-related brain regions of interest. Twenty patients with schizophrenia and 25 controls underwent functional magnetic resonance imaging while rating the degree of relevance between faces (self, familiar other, or unfamiliar other) and words (positive, negative, or neutral)...
August 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27336057/evidence-of-structural-invariance-across-three-groups-of-meehlian-schizotypes
#20
Raymond Ck Chan, Diane C Gooding, Hai-Song Shi, Fu-Lei Geng, Dong-Jie Xie, Zhuo-Ya Yang, Wen-Hua Liu, Yi Wang, Chao Yan, Chuan Shi, Simon Sy Lui, Eric Fc Cheung
According to Meehl's model of schizotypy, there is a latent personality organization associated with the diathesis for schizophrenia that can be identified in several ways. We sought to examine the structural invariance of four Chapman psychosis-proneness scales (CPPS) across three groups of putative schizotypes, namely, clinically-, biologically-, and psychometrically-identified schizotypes. We examined the factor structure of the Perceptual Aberration (PER), Magical Ideation (MIS), Revised Social Anhedonia (RSAS), and Revised Physical Anhedonia (RPAS) scales in 196 schizophrenia patients, 197 non-psychotic first-degree relatives, and 1,724 non-clinical young adults...
2016: NPJ Schizophrenia
keyword
keyword
89180
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"