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Schizophrenia anhedonia

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https://www.readbyqxmd.com/read/28869096/profiling-of-experiential-pleasure-emotional-regulation-and-emotion-expression-in-patients-with-schizophrenia
#1
Ying-Min Zou, Ke Ni, Zhuo-Ya Yang, Ying Li, Xin-Lu Cai, Dong-Jie Xie, Rui-Ting Zhang, Fu-Chun Zhou, Wen-Xiu Li, Simon S Y Lui, David H K Shum, Eric F C Cheung, Raymond C K Chan
BACKGROUND: Emotion deficits may be the basis of negative symptoms in schizophrenia patients and they are prevalent in these patients. However, inconsistent findings about emotion deficits in schizophrenia suggest that there may be subtypes. AIM: The present study aimed to examine and profile experiential pleasure, emotional regulation and expression in patients with schizophrenia. METHODS: A set of checklists specifically capturing experiential pleasure, emotional regulation, emotion expression, depressive symptoms and anhedonia were administered to 146 in-patients with schizophrenia and 73 demographically-matched healthy controls...
August 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28864283/covariation-between-motor-signs-and-negative-symptoms-in-drug-naive-subjects-with-schizophrenia-spectrum-disorders-before-and-after-antipsychotic-treatment
#2
Victor Peralta, Elena García de Jalón, María S Campos, Manuel J Cuesta
Objective To examine the covariation between negative symptoms and motor signs in a broad sample of drug-naïve subjects with schizophrenia-spectrum psychoses before and after inception of antipsychotic medication. METHODS: One-hundred and eighty-nine antipsychotic-naïve subjects with DSM-IV schizophrenia-spectrum psychoses were assessed for negative symptoms including affective flattening, alogia, avolition/apathy and anhedonia/associality, and motor signs including catatonia, parkinsonism and dyskinesia...
August 29, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28811079/neuroleptic-free-youth-at-ultrahigh-risk-for-psychosis-evidence-diminished-emotion-reactivity-that-is-predicted-by-depression-and-anxiety
#3
June Gruber, Gregory P Strauss, Laure Dombrecht, Vijay A Mittal
Although abnormalities in emotional response have long been considered a core feature of the chronic phase of schizophrenia, few investigations have examined emotional response in individuals at ultrahigh-risk (UHR) for psychosis. We investigated whether neuroleptic-free UHR (n=29) and healthy control (n=32) participants differed in emotional reactivity and emotion regulation on a laboratory-based task that required reporting levels of positive and negative affect to pleasant, unpleasant, and neutral stimuli...
August 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28790020/prenatal-choline-supplementation-attenuates-mk-801-induced-deficits-in-memory-motor-function-and-hippocampal-plasticity-in-adult-male-rats
#4
Chelsea A Nickerson, Alexandra L Brown, Waylin Yu, Yoona Chun, Melissa J Glenn
Choline is essential to the development and function of the central nervous system and supplemental choline during development is neuroprotective against a variety of insults, including neurotoxins like dizocilpine (MK-801). MK-801 is an NMDA receptor antagonist that is frequently used in rodent models of psychological disorders, particularly schizophrenia. At low doses, it causes cognitive impairments, and at higher doses it induces motor deficits, anhedonia, and neuronal degeneration. The primary goals of the present study were to investigate whether prenatal choline supplementation protects against the cognitive impairments, motor deficits, and neuropathologies that are precipitated by MK-801 administration in adulthood...
October 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28779852/negative-symptoms-and-the-formation-of-social-affiliative-bonds-in-schizophrenia
#5
Julie M McCarthy, Kristen R Bradshaw, Lauren T Catalano, Cristina P Garcia, Asia Malik, Melanie E Bennett, Jack J Blanchard
Negative symptoms in schizophrenia are characterized by deficits in normative experiences and expression of emotion, and they are associated with poor social functioning. Negative symptoms relating to deficits in motivation and pleasure may hinder the development of affiliative bonds. The current study used a novel procedure to examine the relation between negative symptoms and the development of social affiliation within a laboratory setting. Fifty-five men (35 controls; 20 with a schizophrenia spectrum disorder) completed three Social Affiliation Enhancement Tasks with an experimenter partner...
August 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28597553/attenuated-positive-psychotic-symptoms-and-the-experience-of-anhedonia
#6
Shanna Cooper, Ann M Kring, Lauren M Ellman
BACKGROUND: Deficits in anticipatory pleasure have been consistently shown among chronic, first-episode, and clinical high risk for psychosis populations, but much less attention has been given to non-clinical individuals experiencing attenuated positive psychotic symptoms (APPS). METHODS: Young adults (N = 1839) were administered the Temporal Experience of Pleasure Scale, which measures anticipatory and consummatory pleasure, and the Prodromal Questionnaire, which measures APPS...
June 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28595147/predictors-of-treatment-response-and-drop-out-in-the-treatment-of-early-onset-schizophrenia-spectrum-disorders-teoss-study
#7
Daniel Gabriel, Ewgeni Jakubovski, Jerome H Taylor, Bekir B Artukoglu, Michael H Bloch
The Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) compared the efficacy of risperidone, olanzapine, and molindone over 8 weeks in 119 youths age 8-19 years with early-onset schizophrenia or schizoaffective disorder. From this large dataset, we examined predictors of treatment response and drop out using stepwise regression and receiver operating characteristics curve (ROC) analysis. Treatment response was defined as having both a ≥ 20% improvement in Positive and Negative Syndrome Scale (PANSS) score and a Clinical Global Impression-Improvement (CGI-I) score < 3...
September 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28531264/cariprazine-exhibits-anxiolytic-and-dopamine-d3-receptor-dependent-antidepressant-effects-in-the-chronic-stress-model
#8
Vanya Duric, Mounira Banasr, Tina Franklin, Ashley Lepack, Nika Adham, Béla Kiss, István Gyertyán, Ronald S Duman
Background: Cariprazine, a D3-preferring dopamine D2/D3 receptor partial agonist, is a new antipsychotic drug recently approved in the US for the treatment of schizophrenia and bipolar mania. We recently demonstrated that cariprazine also has significant anti-anhedonic-like effects in rats subjected to chronic stress; however, the exact mechanism of action for cariprazine's antidepressant-like properties is not known. Thus, in this study we examined whether the effects of cariprazine are mediated by dopamine D3 receptors...
May 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28525603/genome-wide-association-study-of-psychosis-proneness-in-the-finnish-population
#9
Alfredo Ortega-Alonso, Jesper Ekelund, Antti-Pekka Sarin, Jouko Miettunen, Juha Veijola, Marjo-Riitta Järvelin, William Hennah
The current study examined quantitative measures of psychosis proneness in a nonpsychotic population, in order to elucidate their underlying genetic architecture and to observe if there is any commonality to that already detected in the studies of individuals with overt psychotic conditions, such as schizophrenia and bipolar disorder. Heritability, univariate and multivariate genome-wide association (GWAs) tests, including a series of comprehensive gene-based association analyses, were developed in 4269 nonpsychotic persons participating in the Northern Finland Birth Cohort 1966 study with information on the following psychometric measures: Hypomanic Personality, Perceptual Aberration, Physical and Social Anhedonia (also known as Chapman's Schizotypia scales), and Schizoidia scale...
May 19, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28503978/comparison-of-depression-symptoms-between-primary-depression-and-secondary-to-schizophrenia-depression
#10
Twana Rahim, Roshe Rashid
OBJECTIVES: This study exclusively aimed to clinically assess which symptom pattern discriminates primary depression from depression-secondary to-schizophrenia. METHODS: A total of 98 patients with primary depression and 71 patients with secondary-to-schizophrenia depression were assessed for identifying the clinical phenomena of depression. Diagnosis of schizophrenia was confirmed by Mini International Neuropsychiatric Interview. Each participant was, however, assessed by Patient Health Questionnaire-9 as well as Calgary Depression Scale for Schizophrenia (CDSS) for possible concurrent depressive symptoms...
May 15, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28497008/the-positivity-offset-theory-of-anhedonia-in-schizophrenia
#11
Gregory P Strauss, Katherine H Frost, Bern G Lee, James M Gold
Prior studies have concluded that schizophrenia patients are not anhedonic because they do not report reduced experience of positive emotion to pleasant stimuli. The current study challenged this view by applying quantitative methods validated in the Evaluative Space Model of emotional experience to test the hypothesis that schizophrenia patients evidence a reduction in the normative "positivity offset" (i.e., the tendency to experience higher levels of positive than negative emotional output when stimulus input is absent or weak)...
March 2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28460280/investigating-consummatory-and-anticipatory-pleasure-across-motivation-deficits-in-schizophrenia-and-healthy-controls
#12
Susana Da Silva, Sarah Saperia, Ishraq Siddiqui, Gagan Fervaha, Ofer Agid, Z Jeff Daskalakis, Arun Ravindran, Aristotle N Voineskos, Konstantine K Zakzanis, Gary Remington, George Foussias
Anhedonia has traditionally been considered a characteristic feature of schizophrenia, but the true nature of this deficit remains elusive. This study sought to investigate consummatory and anticipatory pleasure as it relates to motivation deficits. Eighty-four outpatients with schizophrenia and 81 healthy controls were administered the Temporal Experience of Pleasure Scale (TEPS), as well as a battery of clinical and cognitive assessments. Multivariate analyses of variance were used to examine the experience of pleasure as a function of diagnosis, and across levels of motivation deficits (i...
August 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28441663/amygdalar-gray-matter-volume-and-social-relating-in-schizophrenia
#13
Vivien Günther, Christian Lindner, Udo Dannlowski, Harald Kugel, Thomas Suslow
BACKGROUND: Poor social relating is a prominent feature of schizophrenia. The amygdala has been suggested as an important node in social brain networks. METHODS: By using structural magnetic resonance imaging, this study examined, for the first time, the relationship between amygdalar gray matter (GM) volume and social relating in 35 schizophrenia patients. Social anhedonia, interaction anxiety, extraversion, and sociable tendencies were assessed as indices of social relating...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28439787/social-withdrawal-among-individuals-receiving-psychiatric-care-derivation-of-a-scale-using-routine-clinical-assessment-data-to-support-screening-and-outcome-measurement
#14
Sebastian Rios, Christopher M Perlman
Social withdrawal is a symptom experienced by individuals with an array of mental health conditions, particularly those with schizophrenia and mood disorders. Assessments of social withdrawal are often lengthy and may not be routinely integrated within the comprehensive clinical assessment of the individual. This study utilized item response and classical test theory methods to derive a Social Withdrawal Scale (SWS) using items embedded within a routine clinical assessment, the RAI-Mental Health (RAI-MH). Using data from 60,571 inpatients in Ontario, Canada, a common factor analysis identified seven items from the RAI-MH that measure social withdrawal...
April 24, 2017: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/28427286/incomes-and-outcomes-social-security-disability-benefits-in-first-episode-psychosis
#15
RANDOMIZED CONTROLLED TRIAL
Robert A Rosenheck, Sue E Estroff, Kyaw Sint, Haiqun Lin, Kim T Mueser, Delbert G Robinson, Nina R Schooler, Patricia Marcy, John M Kane
OBJECTIVE: Social Security Administration (SSA) disability benefits are an important source of income for people with psychoses and confer eligibility for health insurance. The authors examined the impact of coordinated specialty care on receipt of such benefits in first-episode psychosis, along with the correlates and consequences of receiving them. METHOD: The Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study, a 34-site cluster-randomized trial, compared NAVIGATE, a coordinated specialty care program, to usual community care over 2 years...
September 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28419772/visual-memory-uniquely-predicts-anhedonia-in-schizophrenia-but-not-bipolar-disorder
#16
Anjuli S Bodapati, Lisanne M Jenkins, Rajiv P Sharma, Cherise Rosen
OBJECTIVE: Deficits in memory have been suggested as an influential mechanism of anhedonia, because while pleasant experiences may be enjoyed in-the-moment, the cognitive processes involved in reporting anticipated or remembered enjoyable experiences is thought to be impaired. This study will determine whether any aspects of memory, including visual memory, verbal memory or working memory, are significantly predictive of anhedonia in a sample of schizophrenia, psychotic bipolar disorder and healthy controls...
April 17, 2017: Journal of Neuropsychology
https://www.readbyqxmd.com/read/28412089/inverse-association-between-negative-symptoms-and-body-mass-index-in-chronic-schizophrenia
#17
G Mezquida, G Savulich, C Garcia-Rizo, M P Garcia-Portilla, A Toll, L Garcia-Alvarez, J Bobes, A Mané, M Bernardo, E Fernandez-Egea
BACKGROUND: We investigated whether negative symptoms, such as poor motivation or anhedonia, were associated with higher body mass index (BMI) in stable patients with schizophrenia chronically treated with antipsychotic medication. METHODS: 62 olanzapine- or clozapine-treated patients with illness duration of at least four years were selected from an international multicenter study on the characterization of negative symptoms. All participants completed the Brief Negative Symptom Scale (BNSS) and the Positive and Negative Syndrome Scale (PANSS)...
April 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28399104/-a-history-and-overview-of-anhedonia-in-endogenous-mental-disorders
#18
REVIEW
P S Kananovich, A N Barkhatova
Anhedonia is the inability to experience pleasure. This disorder is heterogeneous across psychiatric disorders and is difficult for measuring and submitting to scientific analysis. Over the last several decades there has been increasing interest in the role that anhedonia plays in various psychopathologies. This article reviews the recent literature on anhedonia and its psychopathological features, which are important for prognosis in affective disorders and schizophrenia. Attempts to dissect various subtypes of anhedonia observed in negative syndrome and depression are reviewed as well...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28243163/drug-abuse-and-psychosis-new-insights-into-drug-induced-psychosis
#19
REVIEW
Suji Ham, Tae Kyoo Kim, Sooyoung Chung, Heh-In Im
Addictive drug use or prescribed medicine abuse can cause psychosis. Some representative symptoms frequently elicited by patients with psychosis are hallucination, anhedonia, and disrupted executive functions. These psychoses are categorized into three classifications of symptoms: positive, negative, and cognitive. The symptoms of DIP are not different from the symptoms of schizophrenia, and it is difficult to distinguish between them. Due to this ambiguity of distinction between the DIP and schizophrenia, the DIP animal model has been frequently used as the schizophrenia animal model...
February 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/28242515/emotional-word-usage-in-groups-at-risk-for-schizophrenia-spectrum-disorders-an-objective-investigation-of-attention-to-emotion
#20
Christie K Fung, Melody M Moore, Nicole R Karcher, John G Kerns, Elizabeth A Martin
Both extreme levels of social anhedonia (SocAnh) and extreme levels of perceptual aberration/magical ideation (PerMag) indicate increased risk for schizophrenia-spectrum disorders and are associated with emotional deficits. For SocAnh, there is evidence of self-reported decreased trait positive affect and abnormalities in emotional attention. For PerMag, there is evidence of increased trait negative affect and increased attention to negative emotion. Yet, the nature of more objective emotional abnormalities in these groups is unclear...
June 2017: Psychiatry Research
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