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Schizophrenia anhedonia

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https://www.readbyqxmd.com/read/29687627/anhedonia-in-depression-and-schizophrenia-a-transdiagnostic-challenge
#1
Clare Lambert, Susana Da Silva, Amanda K Ceniti, Sakina J Rizvi, George Foussias, Sidney H Kennedy
BACKGROUND: Anhedonia, as a dysregulation of the reward circuit, is present in both Major Depressive Disorder (MDD) and schizophrenia (SZ). AIMS: To elucidate the clinical and neurobiological differences between schizophrenia (SZ) and depression (MDD) in regard to anhedonia, while reconciling the challenges and benefits of assessing anhedonia as a transdiagnostic feature under the Research Domain Criteria (RDoC) framework. METHODS: In this review, we summarize data from publications examining anhedonia or its underlying reward deficits in SZ and MDD...
April 23, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29680513/the-relationship-between-illicit-amphetamine-use-and-psychiatric-symptom-profiles-in-schizophrenia-and-affective-psychoses
#2
Alexandra Voce, Rebecca McKetin, Richard Burns, David Castle, Bianca Calabria
This study examines whether illicit amphetamine use is associated with differences in the prevalence of specific psychiatric symptoms in a community sample of individuals diagnosed with schizophrenia or affective psychotic disorders. Data was drawn from the Australian Survey of High Impact Psychosis. The Diagnostic Interview for Psychosis was used to measure substance use and psychiatric symptoms. Participants had used amphetamine within their lifetime and had an ICD-10 diagnosis of schizophrenia (n = 347) or an affective psychotic disorder (n = 289)...
April 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29608759/negative-schizotypy-and-altered-functional-connectivity-during-facial-emotion-processing
#3
Yi Wang, Zhi Li, Wen-Hua Liu, Xin-Hua Wei, Xin-Qing Jiang, Simon S Y Lui, Suzanne Ho-Wai So, Eric F C Cheung, Martin Debbane, Raymond C K Chan
Background: Impairment in facial emotion perception is an important domain of social cognition deficits in schizophrenia. Although impaired facial emotion perception has been found in individuals with negative schizotypy (NS), little is known about the corresponding change in brain functional connectivity. Methods: Sixty-four participants were classified into a high NS group (n = 34) and a low NS group (n = 30) based on their total scores on the Chapman scales for physical and social anhedonia...
March 28, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29603866/genome-wide-analysis-of-adolescent-psychotic-like-experiences-shows-genetic-overlap-with-psychiatric-disorders
#4
Oliver Pain, Frank Dudbridge, Alastair G Cardno, Daniel Freeman, Yi Lu, Sebastian Lundstrom, Paul Lichtenstein, Angelica Ronald
This study aimed to test for overlap in genetic influences between psychotic-like experience traits shown by adolescents in the community, and clinically-recognized psychiatric disorders in adulthood, specifically schizophrenia, bipolar disorder, and major depression. The full spectra of psychotic-like experience domains, both in terms of their severity and type (positive, cognitive, and negative), were assessed using self- and parent-ratings in three European community samples aged 15-19 years (Final N incl...
March 31, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29593903/a-possible-link-between-anxiety-and-schizophrenia-and-a-possible-role-of-anhedonia
#5
REVIEW
Luigi Grillo
In the prodromal phase of schizophrenia, severe alterations of the visual appearance of the environment have been found, accompanied by a state of intense anxiety. The present study considers the possibility that these alterations really exist in the appearance of objects, but that healthy people do not see them. The image of the world that we see is continuously deformed and fragmented by foreshortenings, partial overlapping, and so on and must be constantly reassembled and interpreted; otherwise, it could change so much that we would hardly recognize it...
2018: Schizophrenia Research and Treatment
https://www.readbyqxmd.com/read/29573379/dopamine-dysregulation-hypothesis-the-common-basis-for-motivational-anhedonia-in-major-depressive-disorder-and-schizophrenia
#6
Jan Józef Szczypiński, Mateusz Gola
Abnormalities in reward processing are crucial symptoms of major depressive disorder (MDD) and schizophrenia (SCH). Recent neuroscientific findings regarding MDD have led to conclusions about two different symptoms related to reward processing: motivational and consummatory anhedonia, corresponding, respectively, to impaired motivation to obtain rewards ('wanting'), and diminished satisfaction from consuming them ('liking'). One can ask: which of these is common for MDD and SCH. In our review of the latest neuroscientific studies, we show that MDD and SCH do not share consummatory anhedonia, as SCH patients usually have unaltered liking...
March 24, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29532909/the-relationship-between-negative-symptoms-and-depression-in-schizophrenia-a-systematic-review
#7
REVIEW
C R Krynicki, R Upthegrove, J F W Deakin, T R E Barnes
OBJECTIVE: To provide an update on the evidence base for the nature of the relationship between negative symptoms and depressive features in people with schizophrenia, and propose new models that reflect their complex relationship. METHOD: A systematic review following PRISMA guidelines. A total of 2210 articles were identified from EMBASE, PsychInfo and MEDLINE, and further two articles were hand-searched from references. Twenty-seven met inclusion criteria and were included in the review...
May 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29527495/orbitofrontal-sulcogyral-morphology-is-a-transdiagnostic-indicator-of-brain-dysfunction
#8
Marisa A Patti, Vanessa Troiani
Atypical sulcogyral patterns in the orbitofrontal cortex (OFC) are associated with increased risk for schizophrenia, as well as with quantitative traits associated with schizophrenia, such as anhedonia. Here we conduct a cross-diagnostic comparison to assess whether atypical OFC sulcogyral patterns confer risk for multiple brain disorders. We examined structural images from 4 groups of adult participants (N = 189), including those diagnosed with schizophrenia (SZ; N = 49), bipolar disorder (BP; N = 46), attention deficit hyperactivity disorder (ADHD; N = 41), and controls (N = 53)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29526451/impaired-reward-responsiveness-in-schizophrenia
#9
Nicholas Taylor, Jeffrey P Hollis, Sarah Corcoran, Robin Gross, Bruce Cuthbert, Lisette W Swails, Erica Duncan
BACKGROUND: Anhedonia is a core negative symptom of schizophrenia. Schizophrenia patients report largely intact pleasure in consuming rewards, but have impairments in generating motivated behavior to pursue rewards, and show reduced fMRI activation of the reward pathway during presentation of rewarded stimuli. A computer based task measuring the development of a response bias in favor of rewarded stimuli permits assessment of reward-induced motivation. We hypothesized that subjects with schizophrenia would be impaired on this task...
March 8, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29503841/current-perspectives-on-incentive-salience-and-applications-to-clinical-disorders
#10
Jeffrey J Olney, Shelley M Warlow, Erin E Naffziger, Kent C Berridge
Affective neuroscience research has revealed that reward contains separable components of 'liking', 'wanting', and learning. Here we focus on current 'liking' and 'wanting' findings and applications to clinical disorders. 'Liking' is the hedonic impact derived from a pleasant experience, and is amplified by opioid and related signals in discrete sites located in limbic-related brain areas. 'Wanting' refers to incentive salience, a motivation process for reward, and is mediated by larger systems involving mesocorticolimbic dopamine...
August 2018: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/29499966/anhedonia-reflects-impairment-in-making-relative-value-judgments-between-positive-and-neutral-stimuli-in-schizophrenia
#11
Gregory P Strauss, Katherine Frost Visser, William R Keller, James M Gold, Robert W Buchanan
Anhedonia (i.e., diminished capacity to experience pleasure) has traditionally been viewed as a core symptom of schizophrenia (SZ). However, modern laboratory-based studies suggest that this definition may be incorrect, as hedonic capacity may be intact. Alternative conceptualizations have proposed that anhedonia may reflect an impairment in generating mental representations of affective value that are needed to guide decision-making and initiate motivated behavior. The current study evaluated this hypothesis in 42 outpatients with SZ and 19 healthy controls (CN) who completed two tasks: (a) an emotional experience task that required them to indicate how positive, negative, and calm/excited they felt in response to a single emotional or neutral photograph; (b) a relative value judgment task where they selected which of 2 photographs they preferred...
February 27, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29486865/motivational-deficits-in-schizophrenia-are-associated-with-reduced-differentiation-between-gain-and-loss-avoidance-feedback-in-the-striatum
#12
James A Waltz, Ziye Xu, Elliot C Brown, Rebecca R Ruiz, Michael J Frank, James M Gold
BACKGROUND: The current study was designed to test the hypothesis that motivational deficits in schizophrenia (SZ) are tied to a reduced ability to differentially signal gains and instances of loss-avoidance in the brain, leading to reduced ability to form adaptive representations of expected value. METHODS: We administered a reinforcement learning paradigm to 27 medicated SZ patients and 27 control subjects in which participants learned three probabilistic discriminations...
March 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29471331/cross-cultural-validation-and-extension-of-the-clinical-assessment-interview-for-negative-symptoms-cains-in-the-chinese-context-evidence-from-a-spectrum-perspective
#13
Dong-Jie Xie, Hai-Song Shi, Simon S Y Lui, Chuan Shi, Ying Li, Karen K Y Ho, Karen S Y Hung, Wen-Xiu Li, Zheng-Hui Yi, Eric F C Cheung, Ann M Kring, Raymond C K Chan
The Clinical Assessment Interview for Negative Symptoms (CAINS) was designed in accordance with the recent theory and research in social affective neuroscience and to address the psychometric and conceptual limitations of other instruments assessing negative symptoms. The present study aimed to provide a large-scale validation of the CAINS in China and examine its applicability and validity evidence across the schizophrenia spectrum. Using confirmatory factor analysis, our results replicated the original findings in the US development samples that the CAINS possesses a stable 2-factor structure, namely "motivation/pleasure" and "expression"...
February 20, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29410933/using-the-positive-and-negative-syndrome-scale-panss-to-define-different-domains-of-negative-symptoms-prediction-of-everyday-functioning-by-impairments-in-emotional-expression-and-emotional-experience
#14
Philip D Harvey, Anzalee Khan, Richard S E Keefe
Background: Reduced emotional experience and expression are two domains of negative symptoms. The authors assessed these two domains of negative symptoms using previously developed Positive and Negative Syndrome Scale (PANSS) factors. Using an existing dataset, the authors predicted three different elements of everyday functioning (social, vocational, and everyday activities) with these two factors, as well as with performance on measures of functional capacity. Methods: A large (n=630) sample of people with schizophrenia was used as the data source of this study...
December 1, 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29401047/evolutionary-perspectives-on-genetic-and-environmental-risk-factors-for-psychiatric-disorders
#15
Matthew C Keller
Evolutionary medicine uses evolutionary theory to help elucidate why humans are vulnerable to disease and disorders. I discuss two different types of evolutionary explanations that have been used to help understand human psychiatric disorders. First, a consistent finding is that psychiatric disorders are moderately to highly heritable, and many, such as schizophrenia, are also highly disabling and appear to decrease Darwinian fitness. Models used in evolutionary genetics to understand why genetic variation exists in fitness-related traits can be used to understand why risk alleles for psychiatric disorders persist in the population...
January 24, 2018: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/29395876/motivation-deficits-in-individuals-with-social-anhedonia
#16
Jiao Wang, Jia Huang, Simon S Y Lui, Eric F C Cheung, Xiao-Dong Yue, Raymond C K Chan
Patients with schizophrenia have been reported to exhibit anhedonia, a reduced hedonic capacity and deficits in motivation for reward pursuit. However, it is unclear whether these deficits also exist in at-risk individuals prone to psychosis or not. The present study compared 26 individuals with social anhedonia and 28 healthy controls using a grip Effort-based Pleasure Experience Task (E-PET). The findings showed that individuals with social anhedonia did not increase their hard task choices with the elevation of reward magnitude and probability while healthy controls did...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29371026/olfactory-identification-deficit-and-its-relationship-with-hedonic-traits-in-patients-with-first-episode-schizophrenia-and-individuals-with-schizotypy
#17
Lai-Quan Zou, Han-Yu Zhou, Simon S Y Lui, Yi Wang, Ya Wang, Jun Gan, Xiong-Zhao Zhu, Eric F C Cheung, Raymond C K Chan
OBJECTIVE: Olfactory identification impairments have been consistently found in schizophrenia patients. However, few previous studies have investigated this in first-episode patients. There are also inconsistent findings regarding olfactory identification ability in psychometrically-defined schizotypy individuals. In this study, we directly compared the olfactory identification ability of first-episode schizophrenia patients with schizotypy individuals. The relationship between olfactory identification impairments and hedonic traits was also examined...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29362511/neuropsychiatric-phenotypes-produced-by-gaba-reduction-in-mouse-cortex-and-hippocampus
#18
Stefan M Kolata, Kazuhito Nakao, Vivek Jeevakumar, Emily L Farmer-Alroth, Yuko Fujita, Aundrea F Bartley, Sunny Zhihong Jiang, Gregory R Rompala, Robert E Sorge, Dennisse V Jimenez, Keri Martinowich, Yolanda Mateo, Kenji Hashimoto, Lynn E Dobrunz, Kazu Nakazawa
Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. We modeled cortical GAD67 reduction in mice, in which the Gad1 gene is genetically ablated from ~50% of cortical and hippocampal interneurons. Mutant mice showed a reduction of tissue GABA in the hippocampus and cortex including mPFC, and exhibited a cluster of effort-based behavior deficits including decreased home-cage wheel running and increased immobility in both tail suspension and forced swim tests...
May 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29305655/chrfam7a-gene-expression-in-schizophrenia-clinical-correlates-and-the-effect-of-antipsychotic-treatment
#19
Sunil V Kalmady, Rimjhim Agrawal, Deepthi Venugopal, Venkataram Shivakumar, Anekal C Amaresha, Sri Mahavir Agarwal, Manjula Subbanna, Ashwini Rajasekaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
Earlier studies have implicated CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), and its partially duplicated chimeric gene CHRFAM7A in schizophrenia. However, the relationship between the alterations in peripheral gene expression of CHRFAM7A and severity of clinical symptoms has not been examined. Furthermore, potential influence of the antipsychotic medication on CHRFAM7A expression in drug-naive or drug-free schizophrenia is an unexplored area. CHRFAM7A gene expression in lymphocytes was analyzed in 90 antipsychotic-naïve or free schizophrenia patients using TaqMan-based quantitative RT-PCR...
April 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29276350/pleasure-experience-and-emotion-expression-in-patients-with-schizophrenia
#20
Min-Yi Chu, Xu Li, Qin-Yu Lv, Zheng-Hui Yl, Eric F C Cheung, Raymond C K Chan
Background: Impairments in emotional experience and expression have been observed in patients with schizophrenia. However, most previous studies have been limited to either emotional experience (especially anhedonia) or expression. Few studies have examined both the experience and expression of emotion in schizophrenia patients at the same time. Aims: The present study aimed to examine pleasure experience and emotion expression in patients with schizophrenia. In particular, we specifically examined the relationship between emotion impairments (both pleasure experience and expression) and negative symptoms...
October 25, 2017: Shanghai Archives of Psychiatry
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