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Schizophrenia anhedonia

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https://www.readbyqxmd.com/read/29305655/chrfam7a-gene-expression-in-schizophrenia-clinical-correlates-and-the-effect-of-antipsychotic-treatment
#1
Sunil V Kalmady, Rimjhim Agrawal, Deepthi Venugopal, Venkataram Shivakumar, Anekal C Amaresha, Sri Mahavir Agarwal, Manjula Subbanna, Ashwini Rajasekaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
Earlier studies have implicated CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), and its partially duplicated chimeric gene CHRFAM7A in schizophrenia. However, the relationship between the alterations in peripheral gene expression of CHRFAM7A and severity of clinical symptoms has not been examined. Furthermore, potential influence of the antipsychotic medication on CHRFAM7A expression in drug-naive or drug-free schizophrenia is an unexplored area. CHRFAM7A gene expression in lymphocytes was analyzed in 90 antipsychotic-naïve or free schizophrenia patients using TaqMan-based quantitative RT-PCR...
January 5, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29276350/pleasure-experience-and-emotion-expression-in-patients-with-schizophrenia
#2
Min-Yi Chu, Xu Li, Qin-Yu Lv, Zheng-Hui Yl, Eric F C Cheung, Raymond C K Chan
Background: Impairments in emotional experience and expression have been observed in patients with schizophrenia. However, most previous studies have been limited to either emotional experience (especially anhedonia) or expression. Few studies have examined both the experience and expression of emotion in schizophrenia patients at the same time. Aims: The present study aimed to examine pleasure experience and emotion expression in patients with schizophrenia. In particular, we specifically examined the relationship between emotion impairments (both pleasure experience and expression) and negative symptoms...
October 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29237066/early-motor-developmental-milestones-and-schizotypy-in-the-northern-finland-birth-cohort-study-1966
#3
Svetlana Filatova, Heli Koivumaa-Honkanen, Golam M Khandaker, Estelle Lowry, Tanja Nordström, Tuula Hurtig, Kristiina Moilanen, Jouko Miettunen
Delayed motor developmental milestones have been reported to be associated with schizophrenia in previous studies, but no study has examined the relationship between early motor developmental milestones and schizotypy. We have examined this relationship in a prospective birth cohort.In the Northern Finland Birth Cohort 1966, data on 9 early motor developmental milestones were collected prospectively from visits to child welfare centers, and data on adult schizotypy were collected through a questionnaire (N = 4557-4674)...
December 9, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29230398/insulin-signaling-deficiency-produces-immobility-in-caenorhabditis-elegans-that-models-diminished-motivation-states-in-man-and-responds-to-antidepressants
#4
Julie Dagenhardt, Angeline Trinh, Halen Sumner, Jeffrey Scott, Eric Aamodt, Donard S Dwyer
Defects in insulin signaling have been reported in schizophrenia and major depressive disorder, which also share certain negative symptoms such as avolition, anhedonia, and apathy. These symptoms reflect diminished motivational states, which have been modeled in rodents as increased immobility in the forced swimming test. We have discovered that loss-of-function mutations in the insulin receptor (daf-2) and syntaxin (unc-64) genes in Caenorhabditis elegans, brief food deprivation, and exposure to DMSO produce immobility and avolition in non-dauer adults...
November 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29218852/psychotic-conversion-of-individuals-at-ultra-high-risk-for-psychosis-the-potential-roles-of-schizotypy-and-basic-symptoms
#5
Minji Bang, Jin Young Park, Kyung Ran Kim, Su Young Lee, Yun Young Song, Jee In Kang, Eun Lee, Suk Kyoon An
AIM: To improve strategies for the early identification of individuals at a heightened risk for the development of psychosis, we investigated the relationships and interactions between 3 psychosis-proneness dimensions for the development of schizophrenia spectrum psychosis: schizotypy, basic symptoms and the ultra-high risk (UHR) criteria. METHODS: Seventy-seven UHR individuals and 79 healthy controls were assessed for schizotypy and basic symptoms using self-report questionnaires at baseline...
December 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29195921/social-cognition-and-self-other-distinctions-in-neuropsychiatry-insights-from-schizophrenia-and-tourette-syndrome
#6
REVIEW
Clare M Eddy
Impairments in social cognition may reflect dysfunction of disorder specific or disorder general mechanisms. Although cross-disorder comparison may prove insightful, few studies have compared social cognition in different neuropsychiatric disorders. Parallel investigation of schizophrenia and Tourette syndrome (TS) is encouraged by similarities including the presence of problematic social behavior, echophenomena, emotional dysregulation and dopamine dysfunction. Focusing on tests of social cognition administered in both disorders, this review aims to summarize behavioral, neurophysiological and neuroimaging findings, before exploring how these may contribute to clinical symptoms...
November 28, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29195165/psychometric-evaluation-of-the-temporal-experience-of-pleasure-scale-teps-in-a-german-sample
#7
Joe J Simon, Johannes Zimmermann, Sheila A Cordeiro, Ina Marée, David E Gard, Hans-Christoph Friederich, Matthias Weisbrod, Stefan Kaiser
Anhedonia, or the inability to experience pleasure, is commonly observed in schizophrenia. It has been suggested that patients with schizophrenia are unable to predict future pleasurable events, but show intact experience of in-the-moment pleasure. Therefore, the Temporal Experience of Pleasure Scale (TEPS), a self-report measure allowing the assessment of anticipatory and consummatory pleasure, has been developed. To validate the German version of the TEPS, we recruited 59 healthy control participants and 51 patients with schizophrenia or schizoaffective disorder who completed the TEPS as well as a battery of psychometric tests to assess psychopathology, in particular self-rated anhedonia and clinician-rated apathy as well as overall measures of negative symptoms...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29171010/prenatal-exposure-to-ketamine-in-rats-implications-on-animal-models-of-schizophrenia
#8
Carlos M Coronel-Oliveros, Renny Pacheco-Calderón
Schizophrenia is a complex neuropsychiatric disorder characterized by hallucinations, delusions, anhedonia, flat affect and cognitive impairments. The aim of this study was to propose a prenatal treatment with ketamine, a psychedelic drug that acts as a non-competitive inhibitor of glutamate NMDA receptors, as a neurodevelopmental animal model of schizophrenia. The drug was applied (i.m. 60 mg.kg(-1)  h(-1) ) in pregnant Sprague-Dawley rats on gestational Day 14. Offspring behavior was studied on pubertal (4 weeks old) and adult (10 weeks old) stages...
November 24, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29168305/the-trajectory-of-anhedonic-and-depressive-symptoms-in-anorexia-nervosa-a-longitudinal-and-cross-sectional-approach
#9
Ilka Boehm, Luisa Flohr, Julius Steding, Larissa Holzapfel, Jochen Seitz, Veit Roessner, Stefan Ehrlich
Anhedonia, the inability to experience pleasure, is associated with depression, schizophrenia and also anorexia nervosa (AN). However, it remains unanswered whether anhedonic symptoms in AN are undernutrition-dependent depressive symptoms or a core feature of AN. Therefore, we aim at investigating the trajectory of anhedonic and depressive symptoms over the course of the disorder. Self-reported symptoms were collected in 35 nonmedicated acutely ill, 33 long-term recovered patients and 62 healthy females. The majority of the acutely ill (n = 24) were followed up after >15% weight restoration (short-term recovery)...
November 23, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29128326/cognitive-remediation-can-improve-negative-symptoms-and-social-functioning-in-first-episode-schizophrenia-a-randomized-controlled-trial
#10
Joseph Ventura, Kenneth L Subotnik, Denise Gretchen-Doorly, Laurie Casaus, Michael Boucher, Gerhard S Hellemann, Keith H Nuechterlein
BACKGROUND: Meta-analyses have reported that the effects of cognitive remediation might go beyond improvement in cognition to include unexpected benefits for schizophrenia patients such as negative symptom reduction and improvements in functioning. In addition, some evidence indicated that these potentially beneficial effects are also present in the initial course of schizophrenia, but work in this area is still developing. METHOD: A RCT compared Cognitive Remediation (CR) to Healthy Behaviors Training (HBT) in 80 patients (78% male) with a mean age of 21...
November 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29055240/automatic-processing-of-emotional-facial-expressions-as-a-function-of-social-anhedonia
#11
Vivien Günther, Juliane Zimmer, Anette Kersting, Karl-Titus Hoffmann, Donald Lobsien, Thomas Suslow
Anhedonia is an important feature of major depression and schizophrenia-spectrum disorders. Few neuroimaging studies have investigated neural alterations in high anhedonia, isolated from other psychopathological variables, by including only participants without clinical diagnoses. The present study examined healthy individuals scoring high (N = 18) vs. low (N = 19) in social anhedonia, who were carefully selected from a sample of N = 282 participants. To examine differences in automatic brain responses to social-affective stimuli between high vs...
December 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29049906/interaction-between-compound-genetic-risk-for-schizophrenia-and-high-birth-weight-contributes-to-social-anhedonia-and-schizophrenia-in-women
#12
Johanna Liuhanen, Jaana Suvisaari, Eero Kajantie, Jouko Miettunen, Antti-Pekka Sarin, Marjo-Riitta Järvelin, Jouko Lönnqvist, Juha Veijola, Tiina Paunio
Schizophrenia is a highly heritable disease, but despite extensive study, its genetic background remains unresolved. The lack of environmental measures in genetic studies may offer some explanation. In recent Finnish studies, high birth weight was found to increase the risk for familial schizophrenia. We examined the interaction between a polygenic risk score for schizophrenia and high birth weight on social anhedonia and schizophrenia in a general population birth cohort. The study sample included 4223 participants from the 1966 Northern Finland Birth Cohort...
October 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29033618/schizophrenia-and-sleep-disorders-links-risks-and-management-challenges
#13
REVIEW
Rachel E Kaskie, Bianca Graziano, Fabio Ferrarelli
Schizophrenia is a major psychiatric disorder that has a massive, long-lasting negative impact on the patients as well as society. While positive symptoms (i.e., delusions and hallucinations), negative symptoms (i.e., anhedonia, social withdrawal), and cognitive impairments are traditionally considered the most prominent features of this disorder, the role of sleep and sleep disturbances has gained increasing prominence in clinical practice. Indeed, the vast majority of patients with schizophrenia report sleep abnormalities, which tend to precede illness onset and can predict an acute exacerbation of psychotic symptoms...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29033027/anhedonia-following-early-life-adversity-involves-aberrant-interaction-of-reward-and-anxiety-circuits-and-is-reversed-by-partial-silencing-of-amygdala-corticotropin-releasing-hormone-gene
#14
Jessica L Bolton, Jenny Molet, Limor Regev, Yuncai Chen, Neggy Rismanchi, Elizabeth Haddad, Derek Z Yang, Andre Obenaus, Tallie Z Baram
BACKGROUND: Anhedonia, the diminished ability to experience pleasure, is an important dimensional entity linked to depression, schizophrenia, and other emotional disorders, but its origins and mechanisms are poorly understood. We have previously identified anhedonia, manifest as decreased sucrose preference and social play, in adolescent male rats that experienced chronic early-life adversity/stress (CES). Here we probed the molecular, cellular, and circuit processes underlying CES-induced anhedonia and tested them mechanistically...
January 15, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29017618/dissociation-between-affective-experience-and-motivated-behaviour-in-schizophrenia-patients-and-their-unaffected-first-degree-relatives-and-schizotypal-individuals
#15
Dong-Jie Xie, Simon S Y Lui, Fu-Lei Geng, Zhuo-Ya Yang, Ying-Min Zou, Ying Li, Hera K H Yeung, Eric F C Cheung, Erin A Heerey, Raymond C K Chan
BACKGROUND: The neuropsychological origins of negative syndrome of schizophrenia remain elusive. Evidence from behavioural studies, which utilised emotion-inducing pictures to elicit motivated behaviour generally reported that that schizophrenia patients experienced similar affective experience as healthy individuals but failed to translate emotional salience to motivated behaviour, a phenomenon called emotion-behaviour decoupling. However, a few studies have examined emotion-behaviour decoupling in non-psychotic high-risk populations, who are relatively unaffected by medication effects...
October 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28981913/olfactory-functioning-in-first-episode-psychosis
#16
Vidyulata Kamath, Patricia Lasutschinkow, Koko Ishizuka, Akira Sawa
BACKGROUND: Though olfactory deficits are well-documented in schizophrenia, fewer studies have examined olfactory performance profiles across the psychosis spectrum. The current study examined odor identification, discrimination, and detection threshold performance in first-episode psychosis (FEP) patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depression with psychotic features, and other psychotic conditions. METHOD: FEP patients (n = 97) and healthy adults (n = 98) completed birhinal assessments of odor identification, discrimination, and detection threshold sensitivity for lyral and citralva...
August 31, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28869096/profiling-of-experiential-pleasure-emotional-regulation-and-emotion-expression-in-patients-with-schizophrenia
#17
Ying-Min Zou, Ke Ni, Zhuo-Ya Yang, Ying Li, Xin-Lu Cai, Dong-Jie Xie, Rui-Ting Zhang, Fu-Chun Zhou, Wen-Xiu Li, Simon S Y Lui, David H K Shum, Eric F C Cheung, Raymond C K Chan
BACKGROUND: Emotion deficits may be the basis of negative symptoms in schizophrenia patients and they are prevalent in these patients. However, inconsistent findings about emotion deficits in schizophrenia suggest that there may be subtypes. AIM: The present study aimed to examine and profile experiential pleasure, emotional regulation and expression in patients with schizophrenia. METHODS: A set of checklists specifically capturing experiential pleasure, emotional regulation, emotion expression, depressive symptoms and anhedonia were administered to 146 in-patients with schizophrenia and 73 demographically-matched healthy controls...
August 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28864283/covariation-between-motor-signs-and-negative-symptoms-in-drug-naive-subjects-with-schizophrenia-spectrum-disorders-before-and-after-antipsychotic-treatment
#18
Victor Peralta, Elena García de Jalón, María S Campos, Manuel J Cuesta
Objective To examine the covariation between negative symptoms and motor signs in a broad sample of drug-naïve subjects with schizophrenia-spectrum psychoses before and after inception of antipsychotic medication. METHODS: One-hundred and eighty-nine antipsychotic-naïve subjects with DSM-IV schizophrenia-spectrum psychoses were assessed for negative symptoms including affective flattening, alogia, avolition/apathy and anhedonia/associality, and motor signs including catatonia, parkinsonism and dyskinesia...
August 29, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28811079/neuroleptic-free-youth-at-ultrahigh-risk-for-psychosis-evidence-diminished-emotion-reactivity-that-is-predicted-by-depression-and-anxiety
#19
June Gruber, Gregory P Strauss, Laure Dombrecht, Vijay A Mittal
Although abnormalities in emotional response have long been considered a core feature of the chronic phase of schizophrenia, few investigations have examined emotional response in individuals at ultrahigh-risk (UHR) for psychosis. We investigated whether neuroleptic-free UHR (n=29) and healthy control (n=32) participants differed in emotional reactivity and emotion regulation on a laboratory-based task that required reporting levels of positive and negative affect to pleasant, unpleasant, and neutral stimuli...
August 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28790020/prenatal-choline-supplementation-attenuates-mk-801-induced-deficits-in-memory-motor-function-and-hippocampal-plasticity-in-adult-male-rats
#20
Chelsea A Nickerson, Alexandra L Brown, Waylin Yu, Yoona Chun, Melissa J Glenn
Choline is essential to the development and function of the central nervous system and supplemental choline during development is neuroprotective against a variety of insults, including neurotoxins like dizocilpine (MK-801). MK-801 is an NMDA receptor antagonist that is frequently used in rodent models of psychological disorders, particularly schizophrenia. At low doses, it causes cognitive impairments, and at higher doses it induces motor deficits, anhedonia, and neuronal degeneration. The primary goals of the present study were to investigate whether prenatal choline supplementation protects against the cognitive impairments, motor deficits, and neuropathologies that are precipitated by MK-801 administration in adulthood...
October 11, 2017: Neuroscience
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