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Jean K Mah, Jeffrey T Joseph
PURPOSE OF REVIEW: This article uses a case-based approach to highlight the clinical features as well as recent advances in molecular genetics, muscle imaging, and pathophysiology of the congenital myopathies. RECENT FINDINGS: Congenital myopathies refer to a heterogeneous group of genetic neuromuscular disorders characterized by early-onset muscle weakness, hypotonia, and developmental delay. Congenital myopathies are further classified into core myopathies, centronuclear myopathies, nemaline myopathies, and congenital fiber-type disproportion based on the key pathologic features found in muscle biopsies...
December 2016: Continuum: Lifelong Learning in Neurology
Luyuan Paul Wang, Yann Leconte, Zhenxing Feng, Chao Wei, Yi Zhao, Qing Ma, Wenqian Xu, Samantha Bourrioux, Philippe Azais, Madhavi Srinivasan, Zhichuan J Xu
Laser pyrolyzed SnO2 nanoparticles with an option of nitrogen (N) doping are prepared using a cost-effective method. The electrochemical performance of N-doped samples is tested for the first time in Li-ion batteries where the sample with 3% of N-dopant exhibits optimum performance with a capacity of 522 mAh gactive material(-1) that can be obtained at 10 A g(-1) (6.7C).
December 5, 2016: Advanced Materials
Annelise Y Mah, Megan A Cooper
Metabolism is critical for a host of cellular functions and provides a source of intracellular energy. It has been recognized recently that metabolism also regulates differentiation and effector functions of immune cells. Although initial work in this field has focused largely on T lymphocytes, recent studies have demonstrated metabolic control of innate immune cells, including natural killer (NK) cells. Here, we review what is known regarding the metabolic requirements for NK cell activation, focusing on NK cell production of interferon-gamma (IFN-γ)...
2016: Critical Reviews in Immunology
Christine Till, Austin Noguera, Leonard H Verhey, Julia O'Mahony, E Ann Yeh, Jean K Mah, Katia J Sinopoli, Brian L Brooks, Berengere Aubert-Broche, D Louis Collins, Sridar Narayanan, Douglas L Arnold, Brenda L Banwell
OBJECTIVES: The aim of this study was to describe cognitive, academic, and psychosocial outcomes after an incident demyelinating event (acquired demyelinating syndromes, ADS) in childhood and to investigate the contribution of brain lesions and confirmed MS diagnosis on outcome. METHODS: Thirty-six patients with ADS (mean age=12.2 years, SD=2.7, range: 7-16 years) underwent brain MRI scans at presentation and at 6-months follow-up. T2-weighted lesions on MRI were assessed using a binary classification...
November 2016: Journal of the International Neuropsychological Society: JINS
M J Loveridge, M J Lain, I D Johnson, A Roberts, S D Beattie, R Dashwood, J A Darr, R Bhagat
Lithium iron phosphate, LiFePO4 (LFP) has demonstrated promising performance as a cathode material in lithium ion batteries (LIBs), by overcoming the rate performance issues from limited electronic conductivity. Nano-sized vanadium-doped LFP (V-LFP) was synthesized using a continuous hydrothermal process using supercritical water as a reagent. The atomic % of dopant determined the particle shape. 5 at. % gave mixed plate and rod-like morphology, showing optimal electrochemical performance and good rate properties vs...
November 29, 2016: Scientific Reports
Javier Bezos, Beatriz Álvarez-Carrión, Antonio Rodríguez-Bertos, Álvaro Fernández-Manzano, Lucía de Juan, Cristina Huguet, Víctor Briones, Beatriz Romero
The infection caused by the zoonotic opportunistic pathogen Mycobacterium avium subsp. hominissuis (Mah) was reported for the first time in a pet ferret. Both owners were HIV-positive. Euthanasia of the pet was recommended due to medical reasons and as a preventive action. Disseminated and open tuberculosis lesions were observed in the gastrointestinal and respiratory systems of the ferret. Ecographic and radiographic surveys showed a severe generalized lymphadenopathy, strong thickening of the gastric wall and peritoneum layer...
September 17, 2016: Research in Veterinary Science
A Rajkamal, E Mathan Kumar, V Kathirvel, Noejung Park, Ranjit Thapa
First-principles calculations are performed to identify the pristine and Si doped 3D metallic T6 carbon structure (having both sp(2) and sp(3) type hybridization) as a new carbon based anode material. The π electron of C2 atoms (sp(2) bonded) forms an out of plane network that helps to capture the Li atom. The highest Li storage capacity of Si doped T6 structure with conformation Li1.7Si1C5 produces theoretical specific capacity of 632 mAh/g which substantially exceeding than graphite. Also, open-circuit voltage (OCV) with respect to Li metal shows large negative when compared to the pristine T6 structure...
November 28, 2016: Scientific Reports
Michael B Raizman, Pedram Hamrah, Edward J Holland, Terry Kim, Francis S Mah, Christopher J Rapuano, Roger G Ulrich
Drugs across many pharmacologic classes induce corneal epithelial changes. Many of these drugs have cationic amphiphilic structures, with a hydrophobic ring and hydrophilic cationic amine side chain that allow them to cross cell membranes. These drugs lead to intracellular phospholipid accumulation, often manifested in the cornea by vortex keratopathy, with no effect on visual acuity and few ocular symptoms. Other drugs, notably antineoplastic agents, produce a fine diffuse corneal haze, sometimes accompanied by decreased vision that can be dose limiting...
November 24, 2016: Survey of Ophthalmology
Song Liu, Hongying Hou, Xianxi Liu, Jixiang Duan, Yuan Yao, Qishu Liao, Jing Li, Yunzhen Yang
Hierarchical CuCl with high economic value added (EVA) was successfully recycled with 85% recovery from the acid Cu printed circuit board (Cu-PCB) waste etchant via facile liquid chemical reduction. The micro-structure and morphology of the recycled hierarchical CuCl were systematically characterized in terms of scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET). Furthermore, the corresponding electrochemical performances as lithium ion battery (LIB) anode were also investigated in terms of galvanostatic charge/discharge, cyclic voltammetry (CV) and AC impedance...
October 29, 2016: Journal of Hazardous Materials
Han Zhou, Lusi Zhang, Dongyang Zhang, Shuangqiang Chen, Paul R Coxon, Xiong He, Mike Coto, Hyun-Kyung Kim, Kai Xi, Shujiang Ding
We report a simple synthetic approach to coaxially grow transition metal oxide (TMO) nanostructures on carbon nanotubes (CNT) with ready control of phase and morphology. A thin (~4 nm) sulfonated-polystyrene (SPS) pre-coating is essential for the deposition of transition metal based materials. This layer has abundant sulfonic groups (-SO3(-)) that can effectively attract Ni(2+), Co(2+), Zn(2+) ions through electrostatic interaction and induce them via hydrolysis, dehydration and recrystallization to form coaxial (NiO, Co3O4, NiCoO2 and ZnCo2O4) shells and a nanosheet-like morphology around CNT...
November 25, 2016: Scientific Reports
Sangryun Kim, Woosuk Cho, Xiaobin Zhang, Yoshifumi Oshima, Jang Wook Choi
Lithium ion batteries are encountering ever-growing demand for further increases in energy density. Li-rich layered oxides are considered a feasible solution to meet this demand because their specific capacities often surpass 200 mAh g(-1) due to the additional lithium occupation in the transition metal layers. However, this lithium arrangement, in turn, triggers cation mixing with the transition metals, causing phase transitions during cycling and loss of reversible capacity. Here we report a Li-rich layered surface bearing a consistent framework with the host, in which nickel is regularly arranged between the transition metal layers...
November 25, 2016: Nature Communications
Vladimir P Oleshko, Andrew A Herzing, Christopher L Soles, Jared J Griebel, Woo J Chung, Adam G Simmonds, Jeffrey Pyun
Poly[sulfur-random-(1,3-diisopropenylbenzene)] copolymers synthesized via inverse vulcanization represent an emerging class of electrochemically active polymers recently used in cathodes for Li-S batteries, capable of realizing enhanced capacity retention (1,005 mAh/g at 100 cycles) and lifetimes of over 500 cycles. The composite cathodes are organized in complex hierarchical three-dimensional (3D) architectures, which contain several components and are challenging to understand and characterize using any single technique...
November 24, 2016: Microscopy and Microanalysis
Md Mokhlesur Rahman, Irin Sultana, Tianyu Yang, Zhiqiang Chen, Neeraj Sharma, Alexey M Glushenkov, Ying Chen
A simple, cost-effective, and easily scalable molten salt method for the preparation of Li2 GeO3 as a new type of high-performance anode for lithium-ion batteries is reported. The Li2 GeO3 exhibits a unique porous architecture consisting of micrometer-sized clusters (secondary particles) composed of numerous nanoparticles (primary particles) and can be used directly without further carbon coating which is a common exercise for most electrode materials. The new anode displays superior cycling stability with a retained charge capacity of 725 mAh g(-1) after 300 cycles at 50 mA g(-1) ...
November 23, 2016: Angewandte Chemie
Kannayiram Alagiakrishnan, Darren Mah, Jason R B Dyck, Ambikaipakan Senthilselvan, Justin Ezekowitz
INTRODUCTION: This study on mild cognitive impairment (MCI) in heart failure (HF) compares the utility of Montreal Cognitive Assessment (MoCA) to the Mini-Mental Status Exam (MMSE) for diagnosing MCI in a HF population when compared to the golden standard European Consortium Criteria (ECC). METHODS: Participants were recruited from the Alberta HEART study at the Mazankowski Alberta Heart Institute in Edmonton and St. Mary's hospital in Camrose. This study enrolled 53 community adults aged>50years: 33 HF and 20 controls...
November 9, 2016: International Journal of Cardiology
Shuang Yuan, Yun-Hai Zhu, Wang Li, Sai Wang, Dan Xu, Lin Li, Yu Zhang, Xin-Bo Zhang
SnSe with 3D hierarchical nanostructure composed of interconnected single-crystal SnSe nanosheets is synthesized via a fast and effective strategy. Unexpectedly, when used as anode material for Na-ion batteries (NIBs), the SnSe exhibits a high capacity (738 mAh g(-1) ), superior rate capability (40 A g(-1) ), and high energy density in full cell. These results provide the possibility of SnSe use as NIBs anodes.
November 22, 2016: Advanced Materials
Siew Ling Ong, Siau Hui Mah, How Yee Lai
Eleusine indica (Linnaeus) Gaertner is a traditional herb known to be depurative, febrifuge, and diuretic and has been reported with the highest inhibitory activity against porcine pancreatic lipase (PPL) among thirty two plants screened in an earlier study. This study aims to isolate and identify the active components that may possess high potential as an antiobesity agent. Of the screened solvent fractions of E. indica, hexane fraction showed the highest inhibitory activity of 27.01 ± 5.68% at 100 μg/mL...
2016: Journal of Pharmaceutics
Volkan Etus, Tugba Morali Guler, Hakan Karabagli
AIM: This multicenter study aims to evaluate the incidence of anatomical variations and abnormalities of the third ventricle floor encountered during endoscopic third ventriculostomy (ETV) procedure in myelomeningocele associated hydrocephalus (MAH) cases. MATERIAL AND METHODS: A retrospective analysis was performed on 455 pediatric MAH cases that have been treated with ETV. This case series consisted of the patients who were initially treated with ETV and those who were treated with ETV for the management of cerebrospinal fluid shunt dysfunction as well...
September 21, 2016: Turkish Neurosurgery
Thomas J Conlon, Cathryn S Mah, Christina A R Pacak, Mary B Rucker Henninger, Kirsten E Erger, Marda L Jorgensen, Charles C Lee, Alice F Tarantal, Barry J Byrne
Neuromuscular disorders such as Pompe disease (glycogen storage disease, type II), result in early and potentially irreversible cellular damage with a very limited opportunity for intervention in the newborn period. Pompe disease is due to deficiency in acid α-glucosidase (GAA) leading to lysosomal accumulation of glycogen in all cell types, abnormal myofibrillogenesis, respiratory insufficiency, neurological deficits, and reduced contractile function in striated muscle. Previous studies have shown that fetal delivery of recombinant adeno-associated virus (rAAV) encoding GAA to the peritoneal cavity of Gaa-/- mice resulted in high-level transduction of the diaphragm...
November 17, 2016: Human Gene Therapy. Clinical Development
Martin Roelsgaard, Peter Nørby, Espen Eikeland, Martin Søndergaard, Bo Brummerstedt Iversen
Phase pure polycrystalline MnSb2O4 was synthesised under hydrothermal conditions. Impurities formed outside a narrow range of pH and metal stoichiometric ratios. The structure and its temperature dependence was studied based on multi-temperature conventional single crystal X-ray diffraction (SC-XRD) and high resolution synchrotron powder X-ray diffraction (PXRD). At low temperature (100-300 K) the lattice parameters expanded linearly with thermal expansion coefficients of αa,300 K = 8(1) × 10(-6) K(-1) and αc,300 K = 7...
November 16, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Tatsuya Matsunaga, K Takegoshi
The double-acquisition scheme for efficient data collection of hypercomplex data (the States method) of a two-dimensional experiment is adopted to magic-angle hopping (MAH) and magic-angle turning (MAT) experiments, which are powerful methods to measure the principal values of the chemical shift anisotropy (CSA) in a powder sample. It is shown that the double acquisition MAT (DAMAT) sequence realizes the S/N ratio comparable to or better than those of other variants of the MAH/MAT sequences. In addition, we show that DAMAT has preferable features that there are no spinning sidebands in the indirect dimension, and no spectral shearing is necessary...
November 1, 2016: Journal of Magnetic Resonance
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