Read by QxMD icon Read

Metablic pathways

Lu Huang, Yongjie Zhang, Chenguang Xu, Xiaomei Gu, Linlin Niu, Jinzhi Wang, Xiaoyu Sun, Xiaoming Bai, Xingtian Xuan, Qubei Li, Chunwei Shi, Bing Yu, Heather Miller, Gangyi Yang, Lisa S Westerberg, Wanli Liu, Wenxia Song, Xiaodong Zhao, Chaohong Liu
As the central hub of the metabolism machinery, the mammalian target of rapamycin complex 2 (mTORC2) has been well studied in lymphocytes. As an obligatory component of mTORC2, the role of Rictor in T cells is well established. However, the role of Rictor in B cells still remains elusive. Rictor is involved in B cell development, especially the peripheral development. However, the role of Rictor on B cell receptor (BCR) signaling as well as the underlying cellular and molecular mechanism is still unknown. This study used B cell-specfic Rictor knockout (KO) mice to investigate how Rictor regulates BCR signaling...
August 2017: PLoS Biology
Ying Wang, Shuai Wang, Yongrui Bao, Tianjiao Li, Xin Chang, Guanlin Yang, Xiansheng Meng
BACKGROUND: Gastric ulcer is a common chronic disease in human digestive system, which is difficult to cure, easy to relapse, and endangers human health seriously. Compared with western medicine, traditional Chinese medicine has a unique advantage in improving the general situation, stablizing medical condition, and with little side effects. Glycyrrhiza known as "king of all the medicine", has a range of pharmacological activities and is commonly used in a variety of proprietary Chinese medicines and formulations...
April 2017: Pharmacognosy Magazine
Pooja Sharma, Dhruba K Bhattacharyya, Jugal Kalita
Advancement in science has tended to improve treatment of fatal diseases such as cancer. A major concern in the area is the spread of cancerous cells, technically refered to as metastasis into other organs beyond the primary organ. Treatment in such a stage of cancer is extremely difficult and usually palliative only. In this study, we focus on finding gene-gene network modules which are functionally similar in nature in the case of breast cancer. These modules extracted during the disease progression stages are analyzed using p-value and their associated pathways...
April 21, 2017: Scientific Reports
Fei Wang, Jiayao Zhao, Da Liu, Tong Zhao, Zeming Lu, Lin Zhu, Lingling Cao, Jiaxing Yang, Jingji Jin, Yong Cai
Capsaicin (CAP) is the major pungent component of chili pepper and is being evaluated for use against numerous types of tumors. Although CAP is indicated to target multiple signaling pathways, exact mechanisms of how it disturb cancer cell metablism remain obscure. Recent studies revealed Sirtuin 1 (SIRT1) serves as a potential target of CAP in cancer cells, indicating a direct regulation of cancer cell histone acetylation by capsaicin. The present study evaluated the effect of CAP on gastric cancer (GC) cell lines to understand the mechanism of cell growth inhibition...
November 2016: Cancer Biology & Therapy
Qing-Wei Ruan, Zhuo-Wei Yu, Yong-Xing Ma
Nonhuman primate rhesus monkey is a ideal model for human aging and aging intervention. Same with human aging, rehesus monkey demonstrates age-related aging and diseases in endocrine, neural, immune and cardiovascular system. Coloric restriction can slow down the primary and secondry aging efficently. The mechanism may be to suppress the oxidative stress-inflammaging-DNA damage by mediating the nutrient sensitive metablic signal pathways, and activate damaged DNA repair. However, the differeces of study design, husbandry and diet composition may differently affect CR against the the primary and secondry effects in a long-lived nonhuman primate...
February 2013: Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
Ying Liu, Ping Liu, Yi-Yang Hu, Lieming Xu, Lei Wang, Yongping Mu, Guangli Du
OBJECTIVE: To investigate the effect of Fuzheng Huayu decoction (FHD) intervention on hepatic fibrosis. METHODS: Wistar rats were randomly divided into 3 groups: rats in the normal group only treated with subcutaneous injection of saline, rats in the model group and the FHD group were made into hepatic fibrosis by subcutaneous injection of 40% carbon tetrachloride (CCl4)-olive solution and then those in the FHD group were treated with FHD by gastric perfusion after modeling...
March 2006: Chinese Journal of Integrated Traditional and Western Medicine
M Guo, K Wu, Y Zhuang, J Chu, S Zhang
Kinetics and metabolic shift of DNA recombinant yeast Pichia pastoris was studied in high-density chemostat cultivation in which the glycerol was used as a limited substrate. The experimental results showed that (1) cell optical density (OD600) of Pichia pastoris was linear with its dry cell weight (DCW) and wet cell weight (WCW), and reached 100 OD600 = 128.3 g WCW/L or 100 OD600 = 22.9 g DCW/L; (2) The relationship of specific growth rate (mu) and residual concentration of glycerol is accorded with Monod Equation, to obtain mu = mumax S/(Ks + S), where mumax = 0...
October 2001: Wei Sheng Wu Xue Bao, Acta Microbiologica Sinica
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"