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Fei Wang, Jiayao Zhao, Da Liu, Tong Zhao, Zeming Lu, Lin Zhu, Lingling Cao, Jiaxing Yang, Jingji Jin, Yong Cai
Capsaicin (CAP) is the major pungent component of chili pepper and is being evaluated for use against numerous types of tumors. Although CAP is indicated to target multiple signaling pathways, exact mechanisms of how it disturb cancer cell metablism remain obscure. Recent studies revealed Sirtuin 1 (SIRT1) serves as a potential target of CAP in cancer cells, indicating a direct regulation of cancer cell histone acetylation by capsaicin. The present study evaluated the effect of CAP on gastric cancer (GC) cell lines to understand the mechanism of cell growth inhibition...
November 2016: Cancer Biology & Therapy
Mieko Kimura
Manganese is a metal that has been known named a Greek word "Magnesia" meaning magnesia nigra from Roman Empire. Manganese provide the wide range of metablic function and the multiple abnomalities from its deficiency or toxicity. In 1931, the essentiality of manganese was demonstrated with the authoritative poor growth and declined reproduction in its deficiency. Manganese deficiency has been recognized in a number of species and its signs are impaired growth, impaired reproduction, ataxia, skeletal abnormalities and disorders in lipid and carbohydrate metabolism...
July 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
Wu Li, Jianhua Liu, Umair Ashraf, Gaoke Li, Yuliang Li, Wenjia Lu, Lei Gao, Fuguang Han, Jianguang Hu
γ-aminobutyric acid (GABA) is an endogenous signaling molecule and involved in growth regulations and plant development, however, a little information is available on the consequences of exogenous GABA application on growth, development, and associated physio-biochemical processes in maize. The present study examined the GABA-induced regulations in early growth, net photosynthetic rate, gas exchange, osmoregulation, and enzymatic activities in three maize cultivars, i.e., Yuecainuo 6, Zhengtian 68, and Yuecainuo 2...
2016: Frontiers in Plant Science
Juan Chen, Jun Deng, Yu-yan Zhang, Jian-guo Li, Fei-yu Wu, Hai-tong Wan
OBJECTIVE: To explore the effect of Danshensu on the lipid metabolism of hyperlipidemic rats. METHOD: Sixty clean male SD rats were selected. Twelve of them were selected in the basic control group and fed with common foods, and the remaining rats were fed with the high-fat feeds. After the successful modeling, they were randomly divided into the high-fat control group and low dose (10 mg x kg(-1) x d(-1)), medium dose (20 mg x kg(-1) x d(-1)) and high dose (40 mg x kg(-1) x d(-1)) Danshensu (dissolved in saline) groups...
January 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Liquan Wu, Zhou Taohua, Wenbin Gui, Lisen Xu, Juan Li, YanFeng Ding
Heat stress hurts rice, and floral organs are mostly sensitive to heat stress. We aimed to unravel molecular responses to heat stress in rice floral organs using Illumina/Solexa sequencing technology for addressing the increasing concern of globle warming. At meiophase of the pollen mother cell (pulvinus flat), the plants were stressed for 3 d at 38 C, and RNA was extracted from the stressed pistil and stamen for RNA-Seq sequencing to build the heat stress transcriptom library. A total of 7178 defferentially expressed genes (DEGs) between the normal and heat stress libraries were significant, 61% up-regulated and 39% down-regulated...
July 31, 2015: Biochemical and Biophysical Research Communications
Yan-Jin Chen, Yu-Guang Wang, Zeng-Chun Ma, Cheng-Rong Xiao, Hong-Ling Tan, Qian-De Liang, Xiang-Lin Tang, Yong-Hong Zhao, Dong-Gen Wang, Yue Gao
To study the effect of Panax notoginseng saponins (PNS) on liver drug metabolic enzyme activity, mRNA and protein expressions in rats. Male Wistar rats were randomly divided into nine groups. After administration of the test drugs, their liver microsomes, liver total RNA and total protein were extracted to detect the regulating effect of PNS on liver drug metabolic enzyme activity-related subtype enzymatic activity, mRNA and protein expression by substrate probe, quantitative PCR and Western Blot technology...
October 2014: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ting Yan, Lingling Li, Qinyan Wu, Xiang Gao, Pinjin Hu, Qing He
OBJECTIVE: To investigate the differences in body composition between Crohn's disease(CD) patients and healthy subjects as well as the characteristics of human body composition in various types of CD. METHODS: A total of 57 CD patients were prospectively selected from the Sixth Affiliated Hospital of Sun Yat-sen University as the study group, while 51 healthy subjects as the control group. Protein content, mineral content, fat content, lean body mass, waist circumference, and hip circumference in the two groups were measured by body composition analyzer...
October 2014: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Masahiro Yamamoto, Toshitsugu Sugimoto
Bone metablism of glucocorticoid-induced osteopororsis (GIO) is characterised by transient increase in bone resorption and persistent suppression of bone formation caused by glucocorticoid. Teriparatide is an ideal drug for GIO, because of antagonistic effect against that pathophysiological conditions. Based on new findings of treatment for GIO around the world, teriparatide was selected as one of alternative drugs of the first line agents for GIO in revised version of the guidelines on the management and treatment of GIO of the Japanese Society for Bone and Mineral Research : 2014 update...
September 2014: Clinical Calcium
F Ortun O, J Arbizu, S Cervera
An F-18-FDG-PET study of a pair of monozygotic twins with recent-onset schizophrenia revealed a higher index of metabolic asymmetry (IA) in the medial and posterior thalamus in both cases. Some questions regarding the influence of neuroleptic treatment and handedness on metablic patterns and the role of the thalamus in schizophrenia are discussed in the light of recent studies.
1998: International Journal of Psychiatry in Clinical Practice
Lijing Cai, Jiawen Liu, Lanlin Li, Shaolin Yang, Jian Yang, Qizhi Zhang, Wenxing Peng
OBJECTIVE: To study the pharmacokinetics and brain/plasma concentration ratio of nortriptyline at multiple doses in mice which were pre-treated with physiological saline, piperine and verapamil. METHODS: A total of 216 male Kun Ming mice [(25±3) g] were equally divided into 4 groups randomly. Each group was intragastrically administered physiological saline (B), piperine (170 μg/ kg), piperine (5 mg/kg) and verapamil (5 mg/kg) for 8 days. On the 8th day, 1 h after giving the above drugs, each mice was intraperitoneally injected nortriptyline (13 mg/kg)...
April 2014: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Xiayu Wu, Tianning Zou, Neng Cao, Juan Ni, Weijiang Xu, Tao Zhou, Xu Wang
BACKGROUND: Folate plays a pivotal role in DNA synthesis, repair, methylation and homocysteine (Hcy) metabolism. Therefore, alterations in the folate-mediated one-carbon metabolism may lead to abnormal methylation proliferation, increases of tumor/neoplasia and vein thrombosis/cardiovascular risk. The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism...
2014: Hereditary Cancer in Clinical Practice
Qing-Wei Ruan, Zhuo-Wei Yu, Yong-Xing Ma
Nonhuman primate rhesus monkey is a ideal model for human aging and aging intervention. Same with human aging, rehesus monkey demonstrates age-related aging and diseases in endocrine, neural, immune and cardiovascular system. Coloric restriction can slow down the primary and secondry aging efficently. The mechanism may be to suppress the oxidative stress-inflammaging-DNA damage by mediating the nutrient sensitive metablic signal pathways, and activate damaged DNA repair. However, the differeces of study design, husbandry and diet composition may differently affect CR against the the primary and secondry effects in a long-lived nonhuman primate...
February 2013: Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
L E Bernstein, J R Helm, J C Rocha, M F Almeida, F Feillet, R M Link, M Gizewska
BACKGROUND: Three international surveys were developed aiming to identify the current nutrition educational tools used in the management of phenylketonuria (PKU) and the perceived effectiveness of these tools by clinicians, parents and patients. METHODS: The first two surveys were distributed through the Metabolic Dietitians ListServe (, and the third survey was distributed by international clinics and the National PKU Alliance website (www...
April 2014: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
B M Chassy, E M Gibson, A Guiffrida
Lac variants ofLactobacillus casei subsp.casei DR1002 (formerly 64H) have been produced using acriflavin, ethidium bromide, mitomycin C, or combinations of these agents. Two successive transfers in the presence of acriflavin and mitomycin C or ethidium bromide and mitomycin C resulted in nearly a 100% loss of lactose fermentation. Cesium chloride-ethidium bromide isopycnic gradient ultracentrifugal analysis of purified lysates demonstrated that the 23-mdal plasmid (pDR101) found inL. casei DR1002 was consistently absent in Lac(-) clones...
1978: Current Microbiology
Jarek Mäestu, Jaak Jürimäe, Toivo Jürimäe
Childhood obesity is increasing throughout the world and increases in adipose tissue are related to insulin resistance, cardiovascular diseases and metablic syndrome. Adipose tissue is not simply a storage depot for surplus energy but rather, is an active organ that modulates various biological functions and synthesizes and secretes multiple cytokines into the circulation. Adiponectin and visfatin are two cytokines which are considered to be possible links between obesity, insulin resistance and the metabolic syndrome...
2010: Medicine and Sport Science
Cui-Feng Zhu, Guan-Zhi Li, Hong-Bin Peng, Fan Zhang, Yun Chen, Yong Li
OBJECTIVE: To explore Effects of marine collagen peptides (MCPs) on markers of metablic nuclear receptors, i.e peroxisome proliferator-activated receptor (PPARs), liver X receptor (LXRs) and farnesoid X receptor (FXRs) in type 2 diabetic patients with/without hypertension. METHOD Study population consisted of 200 type 2 diabetic patients with/without hypertension and 50 healthy subjects, all of whom were randomly assigned to MCPs-treated diabetics (n = 50), placebo-treated diabetics (n = 50), MCPs-treated diabetics with hypertension (n=50), placebo-treated diabetics with hypertension (n = 50), and healthy controls (n = 50)...
April 2010: Biomedical and Environmental Sciences: BES
Bo Xi, Li Zhang, Jie Mi
OBJECTIVE: To explore the metabolic syndrome and its association with arterial compliance in Chinese children and adolescents. METHODS: 337 participants aged 6 to 18 years with males accounted for 55.8% were grouped according to their traits of metablic syndrome. Anthropometry, blood pressure, fasting plasma glucose, insulin and serum lipid profile were measured. Homeostasis model was assessed and insulin resistance (HOMA-IR) index was measured and calculated for estimating individual insulin resistance...
April 2010: Biomedical and Environmental Sciences: BES
M Cucuianu, Ioana Brudaşca
More than 40 years ago, our laboratory reported that post-heparin lipolytic activity was decreased in patients with severe atherosclerotic disease, while values recorded in obese and hyperlipidemic subjects without clinically detectable atherosclerotic lesions did not significantly differ from normal weight normolipidemic controls. Because in 1967 data on pathophysiology of lipolytic enzymes were rather scarce, and mainly because our information facilities were limited in those years, we had difficulties in interpreting these results, and the study was to some extent awkwardly approached, as the investigated subjects were not considered according to their gender, body fat patterning and type of hyperlipoproteinemia, and the lipolytic activities of lipoprotein lipase and hepatic lipase had not been selectively assessed...
2008: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
S C Chiesa, R L Irvine, J F Manning
The effect of feast/famine growth conditions on activated sludge cultures indicates that nonfilamentous cultures can be selected by providing proper substrate gradients and extended periods of endogenous metablism. Reactor operating strategies providing intermittently high substrate concentrations result in cultures characterized by high peak substrate and oxygen uptake activities, rapid settling rates, and high resistance to starvation. Sludge settleability can be manipulated using controlled variations in growth environment with corresponding changes noted in sludge activity...
May 1985: Biotechnology and Bioengineering
Shanshan Chen, Ming Ni, Bing Yu, Tingting Lv, Mengji Lu, Feili Gong
MiR-122 is one of the non-coding RNAs which showed its effects on the lipo-metablism, virus infection and HCC forming through regulation of liver gene expression. Its eukaryotic expression vector was constructed by using pSuper which was widely applied in the siRNA expression. The precursor of human miR-122 gene was amplified by polymerase chain reaction (PCR) from the human genomic DNA. The positive clones were screened by PCR and restriction enzyme digestion. The new expression vector of miR-122 was named pHsa-m122...
December 2007: Cellular & Molecular Immunology
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