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https://www.readbyqxmd.com/read/28333365/clozapine-combined-with-different-antipsychotic-drugs-for-treatment-resistant-schizophrenia
#1
REVIEW
Sarah Barber, Uwaila Olotu, Martina Corsi, Andrea Cipriani
BACKGROUND: Between 40% and 70% of people with treatment-resistant schizophrenia do not respond to clozapine, despite adequate blood levels. For these people, a number of treatment strategies have emerged, including the prescription of a second anti-psychotic drug in combination with clozapine. OBJECTIVES: To determine the clinical effects of various clozapine combination strategies with antipsychotic drugs in people with treatment-resistant schizophrenia both in terms of efficacy and tolerability...
March 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28319239/mobile-health-interventions-for-improving-health-outcomes-in-youth-a-meta-analysis
#2
David A Fedele, Christopher C Cushing, Alyssa Fritz, Christina M Amaro, Adrian Ortega
Importance: Mobile health interventions are increasingly popular in pediatrics; however, it is unclear how effective these interventions are in changing health outcomes. Objective: To determine the effectiveness of mobile health interventions for improving health outcomes in youth 18 years or younger. Data Sources: Studies published through November 30, 2016, were collected through PubMed, Cumulative Index to Nursing and Allied Health Literature, Educational Resources Information Center, and PsychINFO...
March 20, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28314804/stereological-monitoring-of-mouse-lung-alveolarization-from-the-early-post-natal-period-to-adulthood
#3
Agnieszka Pozarska, José Alberto Rodríguez-Castillo, David Emanuel Surate Solaligue, Aglaia Ntokou, Philipp Rath, Ivana Mižíková, Alicia Madurga, Konstantin Mayer, István Vadász, Susanne Herold, Katrin Ahlbrecht, Werner Seeger, Rory E Morty
Post-natal lung maturation generates a large number of small alveoli, with concomitant thinning of alveolar septal walls, generating a large gas exchange surface area but minimizing the distance traversed by the gases. This demand for a large and thin gas exchange surface area is not met in disorders of lung development, such as bronchopulmonary dysplasia (BPD), histopathologically characterized by fewer, larger alveoli; and thickened alveolar septal walls. Diseases such as BPD are often modeled in the laboratory mouse to better understand disease pathogenesis, or develop new interventional approaches...
March 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28297800/-a-clinical-study-of-the-association-between-hepatic-controlled-attenuation-parameter-and-metabolic-syndrome
#4
W L Sun, C G Sun, G Y Chen, Q Pan, J Zeng, P P Shan, J G Fan
Objective: To investigate the association between hepatic controlled attenuation parameter (CAP) and metabolic syndrome (MetS) and the correlation of CAP and its changes with the incidence of MetS. Methods: A total of 2461 subjects who underwent physical examination from July 2013 to September 2015 were enrolled. Spearman correlation analysis was used to investigate the correlation of CAP with the number of MetS components and each MetS component, and the chi-square test was used to investigate the prevalence rates of MetS and each component under different CAP levels...
February 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28296783/incidental-thyroid-nodules-on-thoracic-contrast-enhanced-computed-tomography-in-clinical-practice-during-a-10-year-period-characteristics-clinical-outcomes-and-factors-contributing-to-further-evaluation
#5
Ju Yong Park, Kyung Hee Lee, Soon Gu Cho, Yeo Ju Kim, Ha Young Lee, In Ki Hong, Jun Ho Kim
The purposes of this study were to assess the prevalence, malignancy rate, and characteristics of incidental thyroid nodules (ITNs), and to identify factors that contribute the additional workup by ultrasound.The medical records and imaging features of ITNs reported via thoracic computed tomography (CT) were retrospectively reviewed to determine the size, multiplicity, attenuation, shape, and presence of calcification. To identify the factors associated with additional workup, we compared the workup and non-workup groups in terms of nodule characteristics, indications, and CT slices...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28293475/nationwide-hospital-based-survey-of-idiopathic-normal-pressure-hydrocephalus-in-japan-epidemiological-and-clinical-characteristics
#6
Nagato Kuriyama, Masakazu Miyajima, Madoka Nakajima, Michiko Kurosawa, Wakaba Fukushima, Yoshiyuki Watanabe, Etsuko Ozaki, Yoshio Hirota, Akiko Tamakoshi, Etsuro Mori, Takeo Kato, Takahiko Tokuda, Akinori Urae, Hajime Arai
OBJECTIVES: There have been no nationwide epidemiological studies of idiopathic normal pressure hydrocephalus (iNPH) in Japan. Therefore, a nationwide epidemiologic survey of iNPH was performed to determine the number of cases and clinical characteristics by sex and diagnostic level. METHODS: The first survey examined the numbers of cases that met the diagnostic criteria of iNPH and those who underwent shunt operations in 2012. The second survey gathered patients' details to clarify their clinical background characteristics...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28273369/is-estrogen-exposure-a-protective-factor-for-pancreatic-neuroendocrine-tumors-in-female-multiple-endocrine-neoplasia-syndrome-type-1-patients
#7
Wei Qiu, Ioannis Christakis, Ashley A Stewart, Danica M Vodopivec, Angelica Silva-Figueroa, Huiqin Chen, Terri L Woodard, Daniel M Halperin, Jeffrey E Lee, James C Yao, Nancy D Perrier
OBJECTIVE: Pancreatic neuroendocrine tumors (PNETs) are the most common cause of death in multiple endocrine neoplasia type 1 (MEN1) patients. Women have been shown to have improved survival, which may suggest a possible protective effect of female sex hormones. The aim of this study was to evaluate the relationship between estrogen exposure and PNET tumorigenesis, tumor growth, and survival in female MEN1 patients with these tumors. DESIGN: We performed a retrospective chart review of the existing MEN1 database in our institution...
March 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28260758/association-of-metabolic-syndrome-with-hyper-apolipoprotein-b-status-in-young-people-with-acute-coronary-syndrome
#8
G P Aditya, M S Bari, M A Bari, M A Mutalib, G K Paul
Prevalence of Metabolic Syndrome (MetS) and acute coronary syndrome (ACS) in young people is progressively increasing. This was originally a case control study to predict the risk of ACS with hyper apolipoprotein B (Hyper apoB) status in young people, with 50 cases of 18-45 years of age of both sex with first attack of acute coronary syndrome admitted in Coronary care unit of Mymensingh Medical College Hospital from June 2009 to May 2010 and for comparison, equal number of age and sex matched healthy controls were chosen...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28258953/sexual-pleasure-and-function-coital-trauma-and-sex-behaviors-after-voluntary-medical-male-circumcision-among-men-in-the-dominican-republic
#9
Maximo O Brito, Shaveta Khosla, Sheewin Pananookooln, Paul J Fleming, Leonel Lerebours, Yeycy Donastorg, Robert C Bailey
BACKGROUND: Voluntary medical male circumcision (VMMC) is effective in decreasing the risk of HIV acquisition. As men resume sexual activity after circumcision, it will be important to study their satisfaction with the procedure, sexual pleasure and function, coital trauma, and risk compensation (RC), which can hamper or facilitate the long-term success of VMMC programs. AIM: To assess men's satisfaction with VMMC, sexual pleasure and function, coital trauma, and RC after VMMC...
March 1, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28247555/a-critical-review-of-the-effects-of-nicotine-and-alcohol-coadministration-in-human-laboratory-studies
#10
Sarah S Dermody, Christian S Hendershot
Simultaneous use of cigarettes and alcohol is common and may be driven by nicotine increasing alcohol self-administration or vice versa. To better evaluate the causal nature of this relationship, we systematically reviewed human experimental laboratory studies that coadministered nicotine and alcohol with control conditions. Searches of PubMed/MEDLINE and PsycINFO databases and study bibliographies identified 30 studies that met our inclusion criteria. Research methodologies were critically reviewed. Effects of coadministration on drug self-administration and related factors such as craving, subjective response, motivation, and heart rate are reported...
March 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28245208/patients-with-obstructive-sleep-apnea-display-decreased-flow-mediated-dilatation-evidence-from-a-meta-analysis
#11
Yuyu Wang, Huajun Xu, Yingjun Qian, Jian Guan, Hongliang Yi, Shankai Yin
BACKGROUND Endothelial dysfunction, which can be measured by flow-mediated dilatation (FMD), is an early clinical marker of atherosclerosis, which is considered to be the main cause of the observed cardiovascular complications in obstructive sleep apnea (OSA) patients. The association between OSA and endothelial dysfunction has been reported in a number of studies; however, the findings are not entirely consistent. Our aim was to meta-analytically synthesize the existing evidence to explore the association between OSA and endothelial dysfunction...
February 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28203556/complete-mesocolic-excision-in-right-hemicolectomy-comparison-between-hand-assisted-laparoscopic-and-open-approaches
#12
Qin-Song Sheng, Zhe Pan, Jin Chai, Xiao-Bin Cheng, Fan-Long Liu, Jin-Hai Wang, Wen-Bin Chen, Jian-Jiang Lin
PURPOSE: To demonstrate the feasibility, safety, and technical strategies of hand-assisted laparoscopic complete mesocolic excision (HAL-CME) and to compare oncological outcomes between HAL-CME and the open approach (O-CME) for right colon cancers. METHODS: Patients who were scheduled to undergo a right hemicolectomy were divided into HAL-CME and O-CME groups. Measured outcomes included demographic variables, perioperative parameters, and follow-up data. Demographic variables included age, sex distribution, body mass index (BMI), American Society of Anesthesiologists (ASA) physical status classification, previous abdominal surgery, tumor localization, and potential comorbidities...
February 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28202322/sexual-health-competencies-for-undergraduate-medical-education-in-north-america
#13
Carey Roth Bayer, Kristen L Eckstrand, Gail Knudson, Jean Koehler, Scott Leibowitz, Perry Tsai, Jamie L Feldman
INTRODUCTION: The number of hours spent teaching sexual health content and skills in medical education continues to decrease despite the increase in sexual health issues faced by patients across the lifespan. In 2012 and 2014, experts across sexuality disciplines convened for the Summits on Medical School Education and Sexual Health to strategize and recommend approaches to improve sexual health education in medical education systems and practice settings. One of the summit recommendations was to develop sexual health competencies that could be implemented in undergraduate medical education curricula...
February 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28179814/prenatal-stress-immune-programming-of-sex-differences-in-comorbidity-of-depression-and-obesity-metabolic-syndrome
#14
Jill M Goldstein, Laura Holsen, Grace Huang, Bradley D Hammond, Tamarra James-Todd, Sara Cherkerzian, Taben M Hale, Robert J Handa
Major depressive disorder (MDD) is the number one cause of disability worldwide and is comorbid with many chronic diseases, including obesity/metabolic syndrome (MetS). Women have twice as much risk for MDD and comorbidity with obesity/MetS as men, although pathways for understanding this association remain unclear. On the basis of clinical and preclinical studies, we argue that prenatal maternal stress (ie, excess glucocorticoid expression and associated immune responses) that occurs during the sexual differentiation of the fetal brain has sex-dependent effects on brain development within highly sexually dimorphic regions that regulate mood, stress, metabolic function, the autonomic nervous system, and the vasculature...
December 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28178893/sexually-transmitted-infection-prevalence-and-related-risk-factors-among-heterosexual-male-methamphetamine-users-in-china
#15
Dianchang Liu, Zhenxia Jiang, Cuizhen Xiu, Zhizhi Li, Qing Song, Zhenhong Wang
Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11.0. Among the 288 heterosexual male MA users, 51 (17.7%) had syphilis, 36 (12...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28178032/early-life-socioeconomic-disadvantage-and-metabolic-health-disparities
#16
Camelia E Hostinar, Kharah M Ross, Edith Chen, Gregory E Miller
OBJECTIVE: A quarter of the world's population suffers from metabolic syndrome (MetS). MetS prevalence stratifies by socioeconomic status (SES), such that low SES is associated with higher MetS risk. The present study compared the associations between early-life SES and current SES with MetS. METHODS: Participants (N = 354, ages 15-55, M = 36.5 years, SD = 10.7; 55% female; 72.9% White, 16.9% Asian, 10.2% other) were evaluated for SES and MetS. All were in good health, defined as free of chronic medical illness and acute infectious disease...
February 7, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28176005/prognosis-of-video-assisted-thoracoscopic-pulmonary-metastasectomy-in-patients-with-colorectal-cancer-lung-metastases-an-analysis-of-154-cases
#17
Fenghao Sun, Li Chen, Mengkun Shi, Xiaodong Yang, Ming Li, Xinyu Yang, Xiyu Dai, Cheng Zhan, Yu Shi, Qun Wang
PURPOSE: Video-assisted thoracoscopic surgery (VATS) is widely used in thoracic surgery and increasingly applied to pulmonary metastasectomy. The purpose of this study was to identify prognostic factors of patients undergoing VATS pulmonary metastasectomy from colorectal cancer (CRC). METHODS: Between January 2005 and June 2015, a total of 154 patients underwent VATS pulmonary metastasectomy from CRC. Patient demographic data and characteristics of the primary tumor and pulmonary metastasis were analyzed to identify factors significantly correlated with prognosis...
February 7, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28173881/the-needs-of-older-people-with-mental-health-problems-in-a-portuguese-psychiatric-setting
#18
Joaquim Passos, Aníbal Fonte, Cláudia Camila Dias, Lia Fernandes
BACKGROUND: This study aims to identify met and unmet needs, according to the patient, the carer and the staff, and their relationship with socio-demographic and clinical characteristics in elderly people with mental health problems. METHODS: A sample of 306 elderly patients ≥65 years, of both sexes, diagnosed with mental illness (ICD-10 criteria), was recruited from inpatient/outpatient settings in a Department of Psychiatry and Mental Health, in northern Portugal...
February 8, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28159560/are-bariatric-operations-performed-by-residents-safe-and-efficient
#19
Piotr Major, Michał Wysocki, Jadwiga Dworak, Michał Pędziwiatr, Piotr Małczak, Andrzej Budzyński
BACKGROUND: The growing need for surgeons who are educated and trained in bariatric surgery has raised many issues related to training in this field. OBJECTIVES: This study was performed to evaluate the safety and efficacy of laparoscopic sleeve gastrectomy (SG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) performed by doctors-in-training during their residency in general surgery. SETTING: Tertiary referral university teaching hospital, Poland...
November 23, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28133933/the-possibility-of-radiotherapy-as-downstaging-to-living-donor-liver-transplantation-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus
#20
LETTER
Jin Y Choi, Jeong I Yu, Hee C Park, C H David Kwon, Jong M Kim, Jae-Won Joh, Gyu-Seong Choi, Jae B Park, Sung J Kim, Seung H Lee, Won-Tae Cho, Kyo W Lee, Byeong-Gon Na, Dong Kyu Oh, Nuri Lee, Chan W Cho, Sanghoon Lee, Suk-Koo Lee
No abstract text is available yet for this article.
April 2017: Liver Transplantation
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