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https://www.readbyqxmd.com/read/27904986/a-qualitative-study-of-clinicians-experience-with-rating-of-the-global-assessment-of-functioning-gaf-scale
#1
I H Monrad Aas, Ove Sonesson, Steffen Torp
The severity of illness in psychiatry is rated using the Global Assessment of Functioning (GAF) scale. The GAF scale is often used in both research settings and in the clinic. The scale ranges from 1 to 100 and is subdivided into ten 10-point intervals, each with verbal rating instructions called anchor points and examples. GAF is an instrument that needs improvement. Studying clinicians' experiences with this rating system may be important for developing improvements. The aim of this study was to collect information from clinicians about their experiences with the GAF instrument, and to collect their ideas on how the GAF scale can be improved, particularly in the area of verbal instructions (i...
November 30, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27894275/perceived-stress-as-a-risk-factor-for-peptic-ulcers-a-register-based-cohort-study
#2
Ulrik Deding, Linda Ejlskov, Mads Phillip Kofoed Grabas, Berit Jamie Nielsen, Christian Torp-Pedersen, Henrik Bøggild
BACKGROUND: The association between stress and peptic ulcers has been questioned since the discovery of helicobacter pylori. This study examined whether high perceived everyday life stress was associated with an increased risk of either receiving a triple treatment or being diagnosed with a peptic ulcer. METHODS: Cohen's perceived stress scale measured the level of stress in a general health survey in 2010 of 17,525 residents of northern Jutland, Denmark, and was linked with National Danish registers on prescription drugs and hospital diagnoses...
November 28, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27881566/association-of-bystander-cardiopulmonary-resuscitation-and-survival-according-to-ambulance-response-times-after-out-of-hospital-cardiac-arrest
#3
Shahzleen Rajan, Mads Wissenberg, Fredrik Folke, Steen M Hansen, Thomas A Gerds, Kristian Kragholm, Carolina Malta Hansen, Lena I M Karlsson, Freddy K Lippert, Lars Køber, Gunnar H Gislason, Christian Torp-Pedersen
BACKGROUND: -Bystander-initiated cardiopulmonary resuscitation (CPR) increases patient survival following out-of-hospital cardiac arrest (OHCA) but it is unknown to what degree bystander CPR remains positively associated with survival with increasing time to potential defibrillation. The main objective was to examine the association of bystander CPR with survival as time to advanced treatment increases. METHODS: -We studied 7,623 OHCA patients between 2005-2011, identified through the nationwide Danish Cardiac Arrest Register...
November 22, 2016: Circulation
https://www.readbyqxmd.com/read/27877035/association-between-hemoglobin-and-prognosis-in-patients-admitted-to-hospital-for-copd
#4
Anne Pernille Toft-Petersen, Christian Torp-Pedersen, Ulla Møller Weinreich, Bodil Steen Rasmussen
Low concentrations of hemoglobin have previously been demonstrated in many patients with COPD. There is evidence of anemia as a prognostic factor in acute exacerbations, but the detailed relationship between concentrations of hemoglobin and mortality is not known. A register-based cohort of patients admitted for the first time to Danish hospitals for acute exacerbations of COPD from 2007 through 2012 was established. Age, sex, comorbidities, medication, renal function, and concentrations of hemoglobin were retrieved...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27872861/danish-nationwide-data-reveal-a-link-between-diabetes-mellitus-diabetic-retinopathy-and-glaucoma
#5
Anna Horwitz, Beáta Éva Petrovski, Christian Torp-Pedersen, Miriam Kolko
Aims. To determine the association between treatment against diabetes mellitus (DM) and treatment with antiglaucomatous drugs in the entire Danish population and to investigate the comorbidity between DM and its complications with antiglaucomatous treatment. Methods. Retrospective nationwide cohort study with data over a 16-year follow-up period. The National Danish Registry of Medicinal Products Statistics was used to identify all claimed prescriptions for antiglaucomatous medication and DM drugs. ICD-10 classifications were furthermore used to identify comorbidities between antiglaucomatous medication and the DM complications, diabetic retinopathy (DR), and nephropathy...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27868157/mcm7-expression-is-a-promising-predictor-of-recurrence-in-patients-surgically-resected-for-meningiomas
#6
Theo L Winther, Sverre H Torp
Patients with high risk of recurrence after meningioma resection might benefit from adjuvant radiation therapy and closer clinical follow-up. While the World Health Organization (WHO) classification and the MIB-1 biomarker are applied in the clinical practice to identify these patients, the reliability of these methods is questionable. To improve the prediction of tumor recurrence, this study evaluated and compared the prognostic usefulness of the biomarker MCM7 with the conventional mitotic index and the MIB-1 biomarker...
November 21, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27867123/the-significance-of-the-extent-of-resection-in-modern-neurosurgical-practice-of-who-grade-i-meningiomas
#7
Theo L Winther, Sverre H Torp
OBJECTIVE: Since the prognostic importance of radical resection was introduced in 1957, the neurosurgery practice has undergone several technological advancements. The aim of this study was evaluate whether the prognostic value of the extent of resection is still relevant in modern neurosurgical practice. Metods: All patients with histological confirmed WHO Grade I meningiomas and who underwent meningioma surgery over a ten year period were retrospectively analyzed. Survival analyses were performed using Kaplan-Meier analysis and univariate and multivariate Cox proportional-hazards regression analyses...
November 17, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27866162/outcomes-associated-with-familial-versus-nonfamilial-atrial-fibrillation-a-matched-nationwide-cohort-study
#8
Anna Gundlund, Jonas Bjerring Olesen, Laila Staerk, Christina Lee, Jonathan P Piccini, Eric D Peterson, Lars Køber, Christian Torp-Pedersen, Gunnar H Gislason, Emil Loldrup Fosbøl
BACKGROUND: We examined all-cause mortality and long-term thromboembolic risk (ischemic stroke, transient ischemic attack, systemic thromboembolism) in patients with and without familial atrial fibrillation (AF). METHODS AND RESULTS: Using Danish nationwide registry data, we identified all patients diagnosed with AF (1995-2012) and divided them into those with familial AF (having a first-degree family member with a prior AF admission) and those with nonfamilial AF...
November 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27845246/palmitate-promotes-inflammatory-responses-and-cellular-senescence-in-cardiac-fibroblasts
#9
Marina Sokolova, Leif Erik Vinge, Katrine Alfsnes, Maria Belland Olsen, Lars Eide, Ole Jørgen Kaasbøll, Håvard Attramadal, May-Kristin Torp, Linn E Fosshaug, Azita Rashidi, Egil Lien, Alexandra Vanessa Finsen, Øystein Sandanger, Pål Aukrust, Trine Ranheim, Arne Yndestad
Palmitate triggers inflammatory responses in several cell types, but its effects on cardiac fibroblasts are at present unknown. The aims of the study were to (1) assess the potential of palmitate to promote inflammatory signaling in cardiac fibroblasts through TLR4 and the NLRP3 inflammasome and (2) characterize the cellular phenotype of cardiac fibroblasts exposed to palmitate. We examined whether palmitate induces inflammatory responses in cardiac fibroblasts from WT, NLRP3(-/-) and ASC(-/-)mice (C57BL/6 background)...
November 12, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27837444/return-to-work-among-self-employed-cancer-survivors
#10
Steffen Torp, Jonn Syse, Alain Paraponaris, Sævar Gudbergsson
PURPOSE: The aim of this study is to investigate whether salaried and self-employed workers differ regarding factors relevant for return to work after being diagnosed with cancer. The possible mediators of an effect of self-employment on work ability were also investigated. METHODS: A total of 1115 cancer survivors (1027 salaried and 88 self-employed) of common invasive cancer types who were in work at the time of diagnosis completed a mailed questionnaire 15-39 months after diagnosis...
November 12, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27837423/the-effects-of-surgery-type-and-different-ossiculoplasty-materials-on-the-hearing-results-in-cholesteatoma-surgery
#11
Sultan Şevik Eliçora, Duygu Erdem, Aykut Erdem Dinç, Murat Damar, Sultan Bişkin
To investigate the effects of surgery type [intact canal wall (ICW) or canal wall down (CWD) mastoidectomy] and different ossiculoplasty materials on hearing outcome in single-staged cholesteatoma surgery. A retrospective case-control study. A total of 116 cases (97 adults, 29 children) underwent surgery, including ossiculoplasty, between 2012 and 2015 for cholesteatoma. Patients who had undergone surgery for the first time, and whose grafts were successful, were included in the study. Patients with adhesive otitis media, unsuccessful grafts, revision and recurrent cases, radical mastoidectomy, and craniofacial anomalies were excluded...
November 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27835965/alcohol-consumption-and-mortality-in-patients-undergoing-coronary-artery-bypass-graft-cabg-a-register-based-cohort-study
#12
Mads Phillip Kofoed Grabas, Steen Møller Hansen, Christian Torp-Pedersen, Henrik Bøggild, Line Rosenkilde Ullits, Ulrik Deding, Berit Jamie Nielsen, Per Føge Jensen, Charlotte Overgaard
BACKGROUND: Previous studies have shown that compared with abstinence and heavy drinking, moderate alcohol consumption is associated with a reduced risk of mortality among the general population and patients with heart failure and myocardial infarction. We examined the association between alcohol consumption and mortality in coronary artery bypass graft (CABG) patients. METHOD: We studied 1,919 first-time CABG patients using data on alcohol consumption and mortality obtained from Danish national registers from March 2006 to October 2011...
November 11, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27824563/adaptive-spectral-envelope-estimation-for-doppler-ultrasound
#13
Aditi Kathpalia, Yucel Karabiyik, Sturla H Eik-Nes, Eva Tegnander, Ingvild Kinn Ekroll, Gabriel Kiss, Hans Torp
Estimation of accurate maximum velocities and spectral envelope in ultrasound Doppler blood flow spectrograms are both essential for clinical diagnostic purposes. However, obtaining accurate maximum velocity is not straightforward due to intrinsic spectral broadening and variance in the power spectrum estimate. The method proposed in this paper for maximum velocity point detection has been developed by modifying an existing method-signal noise slope intersection, incorporating in it steps from an altered version of another method called geometric method...
November 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27824558/an-extended-least-squares-method-for-aliasing-resistant-vector-velocity-estimation
#14
Ingvild Kinn Ekroll, Jorgen Avdal, Abigail Swillens, Hans Torp, Lasse Lovstakken
An extended least squares method for robust, angle-independent 2-D vector velocity estimation using plane-wave ultrasound imaging is presented. The method utilizes a combination of least squares regression of Doppler autocorrelation estimates and block matching to obtain aliasing-resistant vector velocity estimates. It is shown that the aliasing resistance of the technique may be predicted using a single parameter, which is dependent on the selected transmit and receive steering angles. This parameter can therefore be used to design the aliasing-resistant transmit-receive setups...
November 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27823691/the-prevalence-and-prognostic-importance-of-possible-familial-hypercholesterolemia-in-patients-with-myocardial-infarction
#15
Sofie Aagaard Rerup, Lia E Bang, Ulrik M Mogensen, Thomas Engstrøm, Erik Jørgensen, Frants Pedersen, Christian Torp-Pedersen, Gunnar Gislason, Stefan James, Emil Hagström, Lars Køber, Emil L Fosbøl
AIMS: Familial hypercholesterolemia (FH) is a common genetic disorder causing accelerated atherosclerosis and premature cardiovascular disease. The aim of this study was to examine the prevalence and prognostic significance of possible FH in patients with myocardial infarction (MI). METHODS AND RESULTS: By individual-level linkage of data from the Eastern Danish Heart Registry and national administrative registries, a study population of patients referred for coronary angiography due to MI was selected...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27821431/developmental-wiring-of-specific-neurons-is-regulated-by-ret-1-nogo-a-in-caenorhabditis-elegans
#16
Nanna Torpe, Steffen Nørgaard, Anette M Høye, Roger Pocock
Nogo-A is a membrane-bound protein that functions to inhibit neuronal migration, adhesion and neurite outgrowth during development. In the mature nervous system, Nogo-A stabilizes neuronal wiring to inhibit neuronal plasticity and regeneration after injury. Here, we show that RET-1, the sole Nogo-A homolog in Caenorhabditis elegans, is required to control developmental wiring of a specific subset of neurons. In ret-1 deletion mutant animals, specific ventral nerve cord axons are misguided where they fail to respect the ventral midline boundary...
November 7, 2016: Genetics
https://www.readbyqxmd.com/read/27782771/beta-blockers-for-exams-identify-students-at-high-risk-of-psychiatric-morbidity
#17
Jawad H Butt, Søren Dalsgaard, Christian Torp-Pedersen, Lars Køber, Gunnar H Gislason, Christina Kruuse, Emil L Fosbøl
OBJECTIVES: Beta-blockers relieve the autonomic symptoms of exam-related anxiety and may be beneficial in exam-related and performance anxiety, but knowledge on related psychiatric outcomes is unknown. We hypothesized that beta-blocker therapy for exam-related anxiety identifies young students at risk of later psychiatric events. METHODS: Using Danish nationwide administrative registries, we studied healthy students aged 14-30 years (1996-2012) with a first-time claimed prescription for a beta-blocker during the exam period (May-June); students who were prescribed a beta-blocker for medical reasons were excluded...
October 26, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27758943/renal-function-and-the-risk-of-stroke-and-bleeding-in-patients-with-atrial-fibrillation-an-observational-cohort-study
#18
Anders Nissen Bonde, Gregory Y H Lip, Anne-Lise Kamper, Emil L Fosbøl, Laila Staerk, Nicholas Carlson, Christian Torp-Pedersen, Gunnar Gislason, Jonas Bjerring Olesen
BACKGROUND AND PURPOSE: We sought to determine the risk of stroke/thromboembolism and bleeding associated with reduced renal function in patients with atrial fibrillation and the risk of stroke and bleeding associated with warfarin treatment in specific estimated glomerular filtration rate (eGFR) groups. METHODS: We conducted a register-based cohort study and included patients discharged with nonvalvular atrial fibrillation from 1997 to 2011 with available eGFR...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27742807/ischaemic-and-haemorrhagic-stroke-associated-with-non-vitamin-k-antagonist-oral-anticoagulants-and-warfarin-use-in-patients-with-atrial-fibrillation-a-nationwide-cohort-study
#19
Laila Staerk, Emil Loldrup Fosbøl, Gregory Y H Lip, Morten Lamberts, Anders Nissen Bonde, Christian Torp-Pedersen, Brice Ozenne, Thomas Alexander Gerds, Gunnar Hilmar Gislason, Jonas Bjerring Olesen
BACKGROUND: Non-vitamin K antagonist (VKA) oral anticoagulants (NOACs) are widely used as stroke prophylaxis in non-valvular atrial fibrillation (AF), but comparative data are sparse. PURPOSE: To compare dabigatran, rivaroxaban, and apixaban vs. VKA and the risk of stroke/thromboembolism (TE) and intracranial bleeding in AF. METHODS: Using Danish nationwide registries (2011-15), anticoagulant-naïve AF patients were identified when initiating VKA or an NOAC...
October 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27686177/phosphohistone-h3-proliferation-index-is-superior-to-mitotic-index-and-mib-1-expression-as-a-predictor-of-recurrence-in-human-meningiomas
#20
Theo L Winther, Magnus B Arnli, Øyvind Salvesen, Sverre H Torp
OBJECTIVES: This study investigated the prognostic value of the phosphohistone-H3 (PHH3) proliferation index (PI) in human meningiomas and compared the reliability with the conventional mitotic index and MIB-1 biomarker. METHODS: Proliferative activity was determined in 160 patients by standardized immunohistochemistry on tissue microarrays and related to recurrence. RESULTS: All three proliferation assessment methods were significantly associated with World Health Organization grade...
October 2016: American Journal of Clinical Pathology
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