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https://www.readbyqxmd.com/read/28893221/the-indirect-and-direct-pathways-between-physical-fitness-and-academic-achievement-on-commencement-in-post-compulsory-education-in-a-historical-cohort-of-danish-school-youth
#1
Mikkel Porsborg Andersen, Liis Starkof, Maurizio Sessa, Rikke Nørmark Mortensen, Henrik Vardinghus-Nielsen, Henrik Bøggild, Theis Lange, Christian Torp-Pedersen
BACKGROUND: Some studies have found positive associations between physical fitness and academic achievements. Pupils' academic achievements should indicate scholastic abilities to commence a post-compulsory education. However, the effect magnitude of physical fitness and academic achievements on commencement in post-compulsory education is unknown. We examined the pathways between physical fitness and academic achievement on pupils' commencement in post-compulsory education. METHODS: This historical cohort study followed 530 girls and 554 boys from the Danish municipality of Aalborg in the period 2008-2014, 13 to 15 years old in 2010...
September 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28892826/increased-mortality-and-comorbidity-associated-with-leber-s-hereditary-optic-neuropathy-a-nationwide-cohort-study
#2
Nanna Vestergaard, Thomas Rosenberg, Christian Torp-Pedersen, Henrik Vorum, Carl U Andersen, Kristian Aasbjerg
Purpose: Leber's hereditary optic neuropathy (LHON) is a mitochondrial genetic disease in which optic neuropathy is considered a key feature. Several other manifestations of LHON have been reported; however, only little is known of their incidence and the life expectancy in LHON patients. Methods: This study, based on Danish nationwide health registries, included 141 patients diagnosed with LHON and 297 unaffected family members in the maternal line. The incidence of comorbidities and mortality for patients with LHON and unaffected family members was compared with that in the general population...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28877914/age-and-outcomes-of-primary-prevention-implantable-cardioverter-defibrillators-in-patients-with-non-ischemic-systolic-heart-failure
#3
Marie Bayer Elming, Jens C Nielsen, Jens Haarbo, Lars Videbæk, Eva Korup, James Signorovitch, Line Lisbeth Olesen, Per Hildebrandt, Flemming H Steffensen, Niels E Bruun, Hans Eiskjær, Axel Brandes, Anna M Thøgersen, Finn Gustafsson, Kenneth Egstrup, Regitze Videbæk, Christian Hassager, Jesper Hastrup Svendsen, Dan E Høfsten, Christian Torp-Pedersen, Steen Pehrson, Lars Køber, Jens Jakob Thune
Background -The Danish Study to Assess the Efficacy of Implantable Cardioverter Defibrillators (ICD) in Patients with Non-ischemic Systolic Heart Failure on Mortality (DANISH) did not demonstrate an overall effect on all-cause mortality with ICD implantation. However, the pre-specified subgroup analysis suggested a possible age-dependent association between the ICD and mortality with survival benefit seen only in the youngest patients. The nature of this relationship between age and outcome of a primary prevention ICD in patients with non-ischemic systolic heart failure warrants further investigation...
September 6, 2017: Circulation
https://www.readbyqxmd.com/read/28871782/antibiotic-treatment-preventing-necrotising-enterocolitis-alters-urinary-and-plasma-metabolomes-in-preterm-pigs
#4
Pingping Jiang, Alessia Trimigno, Jan Stanstrup, Bekzod Khakimov, Nanna Viereck, Søren Balling Engelsen, Per Torp Sangild, Lars Ove Dragsted
Necrotising enterocolitis (NEC) is a serious gut inflammatory condition in premature neonates, onset and development of which depend on the gut microbiome. Attenuation of the gut microbiome by antibiotics can reduce NEC incidence and severity. However, how the antibiotics-suppressed gut microbiome affects the whole-body metabolism in NEC-sensitive premature neonates is unknown. In formula-fed preterm pigs, used as a model for preterm infants, plasma and urinary metabolomes were investigated by LC-MS and (1)H NMR, with and without antibiotic treatment immediately after birth...
September 14, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28861925/standard-and-reduced-doses-of-dabigatran-rivaroxaban-and-apixaban-for-stroke-prevention-in-atrial-fibrillation-a-nationwide-cohort-study
#5
Laila Staerk, Thomas A Gerds, Gregory Y H Lip, Brice Ozenne, Anders N Bonde, Morten Lamberts, Emil L Fosbøl, Christian Torp-Pedersen, Gunnar H Gislason, Jonas B Olesen
BACKGROUND: Comparative data of non-vitamin K antagonist oral anticoagulants (NOAC) are lacking in patients with atrial fibrillation (AF). OBJECTIVE: We compared effectiveness and safety of standard and reduced dose NOAC in AF patients. METHODS: Using Danish nationwide registries, we included all oral anticoagulant-naïve AF patients who initiated NOAC treatment (2012-2016). Outcome-specific and mortality-specific multiple Cox regressions were combined to compute average treatment effects as 1-year standardized differences in stroke and bleeding risks (g-formula)...
September 1, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28859196/strabismus-incidence-in-a-danish-population-based-cohort-of-children
#6
Tobias Torp-Pedersen, Heather A Boyd, Line Skotte, Birgitte Haargaard, Jan Wohlfahrt, Jonathan M Holmes, Mads Melbye
Importance: To our knowledge, there have been few population-based studies of strabismus incidence conducted. Our population-based study provides valuable data for health services planning and identifying research needs. Objective: To determine the incidence and age distribution of strabismus, overall and by subtype, among children 7 years or younger. Design, Setting, and Participants: This population-based cohort study was conducted with data from 96 842 children enrolled in the Danish National Birth Cohort...
August 31, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28851780/mortality-and-risk-of-cardiac-complications-among-immediate-survivors-of-accidental-electric-shock-a-danish-nationwide-cohort-study
#7
Steen Møller Hansen, Sam Riahi, Søren Hjortshøj, Rikke Mortensen, Lars Køber, Peter Søgaard, Christian Torp-Pedersen
OBJECTIVE: Exposure to electric shock has been associated with an increased risk of developing delayed cardiac arrhythmias and cardiac diseases. We examined whether electric shock patients have an increased risk of developing cardiac disease, cardiac arrhythmias or death compared with the general Danish population. DESIGN: Matched cohort study. SETTING: A nationwide study in Denmark from 1994 to 2011. PARTICIPANTS: We identified 11 462 Danish patients who visited an emergency ward or were admitted to a hospital due to electric shock from 1994 to 2011...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28844192/rivaroxaban-with-or-without-aspirin-in-stable-cardiovascular-disease
#8
John W Eikelboom, Stuart J Connolly, Jackie Bosch, Gilles R Dagenais, Robert G Hart, Olga Shestakovska, Rafael Diaz, Marco Alings, Eva M Lonn, Sonia S Anand, Petr Widimsky, Masatsugu Hori, Alvaro Avezum, Leopoldo S Piegas, Kelley R H Branch, Jeffrey Probstfield, Deepak L Bhatt, Jun Zhu, Yan Liang, Aldo P Maggioni, Patricio Lopez-Jaramillo, Martin O'Donnell, Ajay Kakkar, Keith A A Fox, Alexander N Parkhomenko, Georg Ertl, Stefan Störk, Matyas Keltai, Lars Ryden, Nana Pogosova, Antonio L Dans, Fernando Lanas, Patrick J Commerford, Christian Torp-Pedersen, Tomek J Guzik, Peter B Verhamme, Dragos Vinereanu, Jae-Hyung Kim, Andrew M Tonkin, Basil S Lewis, Camilo Felix, Khalid Yusoff, P Gabriel Steg, Kaj P Metsarinne, Nancy Cook Bruns, Frank Misselwitz, Edmond Chen, Darryl Leong, Salim Yusuf
Background We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. Methods In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction...
August 27, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28841914/the-associations-between-socioeconomic-status-and-risk-of-staphylococcus-aureus-bacteremia-and-subsequent-endocarditis-a-danish-nationwide-cohort-study
#9
Louise Bruun Oestergaard, Michelle D Schmiegelow, Niels Eske Bruun, Robert L Skov, Andreas Petersen, Paal Skytt Andersen, Christian Torp-Pedersen
BACKGROUND: Staphylococcus aureus bacteremia (SAB) is the leading cause of infective endocarditis in several countries. Since socioeconomic status (SES) is known to influence the risk of infectious diseases in general, we aimed to investigate the association between SES and SAB, and risk of subsequent endocarditis in a nationwide adult population. METHODS: All Danish residents were consecutively included at age ≥ 30 years during 1996-2010. We obtained information on SES (highest attained educational level), comorbidities, and microbiologically verified SAB by cross-linking nationwide registries...
August 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28833618/intraoperative-predictors-of-postoperative-takotsubo-syndrome-in-liver-transplant-recipients-an-exploratory-case-control-study
#10
Stephen Aniskevich, Ryan M Chadha, Prith Peiris, C Burcin Taner, Klaus L Torp, Colleen S Thomas, Maria L Yataco, Sher-Lu Pai
INTRODUCTION: Takotsubo syndrome (TTS), also known as Takotsubo's cardiomyopathy or stress induced cardiomyopathy, has been described following a variety of surgeries and disease states. The relationship between intraoperative anesthesia management and the development of this syndrome has never been fully elucidated. OBJECTIVES: The primary objective of this study was to determine the relationship of multiple intraoperative factors on the pathogenesis of TTS. METHODS: A single center retrospective review of all liver transplants performed at Mayo Clinic Florida from January 2005- December 2014...
August 22, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28806310/the-prevention-of-recurrent-cholesteatoma-in-cwu-surgery-the-use-of-titanium-sheeting
#11
Bruce Black, Ian Gutteridge
OBJECTIVE: Assessment of the outcomes of a technique of prevention of recurrent cholesteatoma in canal wall up (CWU) mastoidectomy, using titanium sheeting to repair the external auditory canal wall. PATIENTS: Sixty four cholesteatoma cases were managed during a period from 2007 to 2015. The cases were unselected; the surgery was performed by the senior author. Cholesteatoma Patterns Were: Forty two attic, nine pars tensa, seven combined attic-pars tensa, three congenital, and three other...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28796085/audiometric-outcomes-following-endoscopic-ossicular-chain-reconstruction
#12
Robert J Yawn, Jacob B Hunter, Brendan P O'Connell, George B Wanna, Daniel E Killeen, Cameron C Wick, Brandon Isaacson, Alejandro Rivas
OBJECTIVE: To evaluate the audiometric outcomes following endoscopic ossicular chain reconstruction (OCR). STUDY DESIGN: Retrospective case series. SETTING: Two tertiary referral centers. PATIENTS: Sixty two ears with ossicular discontinuity. INTERVENTION(S): Endoscopic and microscopic OCR in patients with ossicular discontinuity. MAIN OUTCOME MEASURES: Bone and air pure-tone averages (PTA), air-bone gap (ABG), and word recognition scores (WRS)...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28793157/association-of-previous-cesarean-delivery-with-surgical-complications-after-a-hysterectomy-later-in-life
#13
Sofie A I Lindquist, Neel Shah, Charlotte Overgaard, Christian Torp-Pedersen, Karin Glavind, Thomas Larsen, Avery Plough, Grace Galvin, Aage Knudsen
Importance: In recent decades, the global rates of cesarean delivery have rapidly increased. Nonetheless, the influence of cesarean deliveries on surgical complications later in life has been understudied. Objective: To investigate whether previous cesarean delivery increases the risk of reoperation, perioperative and postoperative complications, and blood transfusion when undergoing a hysterectomy later in life. Design, Setting, and Participants: This registry-based cohort study used data from Danish nationwide registers on all women who gave birth for the first time between January 1, 1993, and December 31, 2012, and underwent a benign, nongravid hysterectomy between January 1, 1996, and December 31, 2012...
August 9, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28781149/ultrasound-improves-the-delivery-and-therapeutic-effect-of%C3%A2-nanoparticle-stabilized-microbubbles-in-breast-cancer%C3%A2-xenografts
#14
Sofie Snipstad, Sigrid Berg, Ýrr Mørch, Astrid Bjørkøy, Einar Sulheim, Rune Hansen, Ingeborg Grimstad, Annemieke van Wamel, Astri F Maaland, Sverre H Torp, Catharina de Lange Davies
Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various biological barriers and uneven tumor perfusion. We investigated a unique multifunctional drug delivery system consisting of microbubbles stabilized by polymeric nanoparticles (NPMBs), enabling ultrasound-mediated drug delivery. The aim was to examine mechanisms of ultrasound-mediated delivery and to determine if increased tumor uptake had a therapeutic benefit...
August 3, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28765148/changes-in-retinal-venular-oxygen-saturation-predict-activity-of-proliferative-diabetic-retinopathy-3-months-after-panretinal-photocoagulation
#15
Thomas Lee Torp, Ryo Kawasaki, Tien Yin Wong, Tunde Peto, Jakob Grauslund
BACKGROUND/AIMS: Proliferative diabetic retinopathy (PDR) is a severe blinding condition. We investigated whether retinal metabolism, measured by retinal oximetry, may predict PDR activity after panretinal laser photocoagulation (PRP). METHODS: We performed a prospective, interventional, clinical study of patients with treatment-naive PDR. Wide-field fluorescein angiography (OPTOS, Optomap) and global and focal retinal oximetry (Oxymap T1) were performed at baseline (BL), and 3 months (3M) after PRP...
August 1, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28754388/rationale-design-and-baseline-characteristics-of-participants-in-the-cardiovascular-outcomes-for-people-using-anticoagulation-strategies-compass-trial
#16
REVIEW
Jackie Bosch, John W Eikelboom, Stuart J Connolly, Nancy Cook Bruns, Vivian Lanius, Fei Yuan, Frank Misselwitz, Edmond Chen, Rafael Diaz, Marco Alings, Eva M Lonn, Petr Widimsky, Masatsugu Hori, Alvaro Avezum, Leopoldo S Piegas, Deepak L Bhatt, Kelley R H Branch, Jeffrey L Probstfield, Yan Liang, Lisheng Liu, Jun Zhu, Aldo P Maggioni, Patricio Lopez-Jaramillo, Martin O'Donnell, Keith A A Fox, Ajay Kakkar, Alexander N Parkhomenko, Georg Ertl, Stefan Störk, Katalin Keltai, Matyas Keltai, Lars Ryden, Gilles R Dagenais, Nana Pogosova, Antonio L Dans, Fernando Lanas, Patrick J Commerford, Christian Torp-Pedersen, Tomasz J Guzik, Peter B Verhamme, Dragos Vinereanu, Jae-Hyung Kim, Jong-Won Ha, Andrew M Tonkin, John D Varigos, Basil S Lewis, Camilo Felix, Khalid Yusoff, Philippe Gabriel Steg, Victor Aboyans, Kaj P Metsarinne, Sonia S Anand, Robert G Hart, Andre Lamy, Paul Moayyedi, Darryl P Leong, Mukul Sharma, Salim Yusuf
BACKGROUND: Long-term aspirin prevents vascular events but is only modestly effective. Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone for vascular prevention in patients with stable coronary artery disease (CAD) or peripheral artery disease (PAD). Rivaroxaban as well as aspirin increase upper gastrointestinal (GI) bleeding and this might be prevented by proton pump inhibitor therapy. METHODS: Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) is a double-blind superiority trial comparing rivaroxaban 2...
August 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28749348/fast-simulation-of-dynamic-ultrasound-images-using-the-gpu
#17
Sigurd Storve, Hans Torp
Simulated ultrasound data is a valuable tool for development and validation of quantitative image analysis methods in echocardiography. Unfortunately, simulation time can become prohibitive for phantoms consisting of a large number of point-scatterers. The COLE algorithm by Gao et al. is a fast convolution-based simulator that trades simulation accuracy for improved speed. We present highly efficient parallelized CPU- and GPU-implementations of the COLE algorithm with an emphasis on dynamic simulations involving moving pointscatterers...
July 25, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28728567/settings-and-artefacts-relevant-for-doppler-ultrasound-in-large-vessel-vasculitis
#18
REVIEW
L Terslev, A P Diamantopoulos, U Møller Døhn, W A Schmidt, S Torp-Pedersen
Ultrasound is used increasingly for diagnosing large vessel vasculitis (LVV). The application of Doppler in LVV is very different from in arthritic conditions. This paper aims to explain the most important Doppler parameters, including spectral Doppler, and how the settings differ from those used in arthritic conditions and provide recommendations for optimal adjustments. This is addressed through relevant Doppler physics, focusing, for example, on the Doppler shift equation and how angle correction ensures correctly displayed blood velocity...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28724370/facing-unemployment-study-protocol-for-the-implementation-and-evaluation-of-a-community-based-intervention-for-psychological-well-being-promotion
#19
Ana Virgolino, Maria João Heitor, Joana Carreiras, Elisa Lopes, Simon Øverland, Steffen Torp, Dora Guðmundsdóttir, José Pereira Miguel, M Fátima Reis, Osvaldo Santos
BACKGROUND: Economic crises and unemployment have profound impact on mental health and well-being. Main goal of the Healthy Employment (HE) project is to enhance intersectoral actions promoting mental health among unemployed, namely through the implementation and effectiveness-evaluation of short-term and sustainable group interventions. METHODS: The project follows a RE-AIM-based (Reach, Effectiveness, Adoption, Implementation and Maintenance) framework for assessing a cognitive-behavioural and psychoeducational intervention that has been developed for promoting mental health among unemployed people...
July 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28720151/supplementation-with-lactobacillus-paracasei-or-pediococcus-pentosaceus-does-not-prevent-diarrhoea-in-neonatal-pigs-infected-with-escherichia-coli-f18
#20
Anders D Andersen, Malene S Cilieborg, Charlotte Lauridsen, Anne Louise Mørkbak, Per Torp Sangild
Infectious diarrhoea is a worldwide problem in newborns. Optimal bacterial colonisation may enhance gut maturation and protect against pathogenic bacteria after birth. We hypothesised that lactic acid bacteria (LAB) administration prevents pathogen-induced diarrhoea in formula-fed newborns. Newborn caesarean-delivered, colostrum-deprived term piglets on parenteral nutrition for the first 15 h, were used as models for sensitive newborn infants. A commercially available probiotic strain, Lactobacillus paracasei F19 (LAP, 2·6×108 colony-forming units (CFU)/kg per d) and a novel LAB isolate, Pediococcus pentosaceus (PEP, 1·3×1010 CFU/kg per d), were administered for 5 d with or without inoculation of the porcine pathogen, Escherichia coli F18 (F18, 1010 CFU/d)...
July 2017: British Journal of Nutrition
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