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https://www.readbyqxmd.com/read/29337172/organ-support-therapy-in-the-intensive-care-unit-and-return-to-work-in-out-of-hospital-cardiac-arrest-survivors-a-nationwide-cohort-study
#1
Signe Riddersholm, Kristian Kragholm, Rikke Nørmark Mortensen, Steen Moller Hansen, Mads Wissenberg, Freddy K Lippert, Christian Torp-Pedersen, Christian F Christiansen, Bodil Steen Rasmussen
AIM: With increased survival after out-of-hospital cardiac arrest (OHCA), impact of the post-resuscitation course has become important. Among 30-day OHCA survivors, we investigated associations between organ support therapy in the Intensive Care Unit (ICU) and return to work. METHODS: This Danish nationwide cohort-study included 30-day-OHCA-survivors who were employed prior to arrest. We linked OHCA data to information on in-hospital care and return to work. For patients admitted to an ICU and based on renal replacement therapy (RRT), cardiovascular support and mechanical ventilation, we assessed the prognostic value of organ support therapies in multivariable Cox regression models...
January 11, 2018: Resuscitation
https://www.readbyqxmd.com/read/29326537/total-ossicular-replacement-prosthesis-a-new-fat-interposition-technique
#2
Issam Saliba, Valérie Sabbah, Jackie Bibeau Poirier
Objective: To compare audiometric results between the standard total ossicular replacement prosthesis (TORP-S) and a new fat interposition total ossicular replacement prosthesis (TORP-F) in pediatric and adult patients and to assess the complication and the undesirable outcome. Study design: This is a retrospective study. Methods: This study included 104 patients who had undergone titanium implants with TORP-F and 54 patients who had undergone the procedure with TORP-S between 2008 and 2013 in our tertiary care centers...
2018: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/29244073/incidence-of-infective-endocarditis-among-patients-considered-at-high-risk
#3
Lauge Østergaard, Nana Valeur, Nikolaj Ihlemann, Henning Bundgaard, Gunnar Gislason, Christian Torp-Pedersen, Niels Eske Bruun, Lars Søndergaard, Lars Køber, Emil Loldrup Fosbøl
Aims: Patients with prior infective endocarditis (IE), a prosthetic heart valve, or a cyanotic congenital heart disease (CHD) are considered to be at high risk of IE by guidelines. However, knowledge is sparse on the relative risk of IE between these three groups and compared controls. Methods and results: Using Danish nationwide registries (1996-2015), we identified all patients with prior IE, a prosthetic heart valve, or a complex CHD (defined as tetralogy of Fallot, truncus arteriosus, and transposition of great arteries) as well as matched control populations...
December 12, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29231661/en-botanisk-anestesi
#4
Henrik Andreas Torp, Ingebjørg Gustavsen, Luis Romundstad
No abstract text is available yet for this article.
December 12, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29226811/evidence-based-therapy-and-its-association-with-workforce-detachment-after-first-hospitalization-for-heart-failure
#5
Rasmus Rørth, Emil L Fosbøl, Ulrik M Mogensen, Kristian Kragholm, Pardeep S Jhund, Mark C Petrie, Morten Schou, Gunnar H Gislason, John J V McMurray, Christian Torp-Pedersen, Lars Køber, Søren L Kristensen
OBJECTIVES: This study investigated the association between the use of evidence-based medicine (EBM) for heart failure (HF) and risk of workforce detachment. BACKGROUND: The ability to work can be a marker of functional capacity and quality of life. METHODS: We examined a nationwide cohort of patients in the workforce 1 year after first hospitalization for HF. EBM was defined as treatment with β-blockers and renin angiotensin system inhibitors...
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29224640/return-to-the-workforce-following-infective-endocarditis-a-nationwide-cohort-study
#6
MULTICENTER STUDY
Jawad H Butt, Kristian Kragholm, Michael Dalager-Pedersen, Rasmus Rørth, Søren L Kristensen, Mavish S Chaudry, Nana Valeur, Lauge Østergaard, Christian Torp-Pedersen, Gunnar H Gislason, Lars Køber, Emil L Fosbøl
BACKGROUND: The ability to return to work after infective endocarditis (IE) holds important socioeconomic consequences for both patients and society, yet data on this issue are sparse. We examined return to the workforce and associated factors in IE patients of working age. METHODS: Using Danish nationwide registries, we identified 1,065 patients aged 18-60 years with a first-time diagnosis of IE (1996-2013) who were part of the workforce prior to admission and alive at discharge...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29217395/out-of-hospital-cardiac-arrest-probability-of-bystander-defibrillation-relative-to-distance-to-nearest-automated-external-defibrillator
#7
Kathrine B Sondergaard, Steen Moller Hansen, Jannik L Pallisgaard, Thomas Alexander Gerds, Mads Wissenberg, Lena Karlsson, Freddy K Lippert, Gunnar H Gislason, Christian Torp-Pedersen, Fredrik Folke
AIMS: Despite wide dissemination of automated external defibrillators (AEDs), bystander defibrillation rates remain low. We aimed to investigate how route distance to the nearest accessible AED was associated with probability of bystander defibrillation in public and residential locations. METHODS: We used data from the nationwide Danish Cardiac Arrest Registry and the Danish AED Network to identify out-of-hospital cardiac arrests and route distances to nearest accessible registered AED during 2008-2013...
December 4, 2017: Resuscitation
https://www.readbyqxmd.com/read/29212117/renal-function-time-in-therapeutic-range-and-outcomes-in-warfarin-treated-atrial-fibrillation-patients-a-retrospective-analysis-of-nationwide-registries
#8
Anders Nissen Bonde, Gregory Y H Lip, Anne-Lise Kamper, Laila Staerk, Christian Torp-Pedersen, Gunnar Gislason, Jonas Bjerring Olesen
No abstract text is available yet for this article.
December 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29198736/venous-thromboembolic-complications-to-hysterectomy-for-benign-disease-a-nationwide-cohort-study
#9
Henriette Strøm Kahr, Ole Thorlacius-Ussing, Ole Bjarne Christiansen, Regitze Kuhr Skals, Christian Torp-Pedersen, Aage Knudsen
STUDY OBJECTIVE: To estimate the risk of venous thromboembolic complications following abdominal, laparoscopic and vaginal hysterectomy when performed for benign disorders. DESIGN: Nationwide cohort study (Canadian Task Force Classification II-2). SETTING: Data from Danish national registers on all women undergoing hysterectomy for benign conditions in the period 1996-2015. PATIENTS: Women aged 18 and above who underwent hysterectomy for benign disease were stratified into 3 groups according to hysterectomy approach: abdominal, laparoscopic or vaginal...
November 30, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29193789/temporal-changes-in-retinal-vascular-parameters-associated-with-successful-panretinal-photocoagulation-in-proliferative-diabetic-retinopathy-a-prospective-clinical-interventional-study
#10
Thomas Lee Torp, Ryo Kawasaki, Tien Yin Wong, Tunde Peto, Jakob Grauslund
PURPOSE: We aimed to investigate changes in retinal vascular geometry over time after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR). METHODS: Thirty-seven eyes with PDR were included. Wide-field fluorescein angiography (Optomap, Optos PLC., Dunfermline, Scotland, UK) was used to diagnose PDR at baseline and to assess activity at follow-up month three and six. At each time-point, a trained grader measured retinal vessel geometry on optic disc (OD) centred images using semiautomated software (SIVA, Singapore I Vessel Assessment, National University of Singapore, Singapore) according to a standardized protocol...
November 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29187197/changes-in-clavicle-length-in-acute-fractures-within-3%C3%A2-weeks-a-prospective-ultrasonographic-study-of-59-patients
#11
A H Thorsmark, O M Christensen, S Torp-Pedersen, S Overgaard, L H Frich
BACKGROUND: Within traumatology a common indication for acute surgery of fractured clavicles is bone shortening over 2 cm. This indication is among but a few indications; which are recommended to be treated operatively within the very first weeks after a fracture. Theoretically clavicle fractures could become less shortened over time due to decreasing muscle pull. If this reduced shortening does indeed happen, some patients with initial bone shortening over 2 cm could perhaps be treated conservatively? However, it is unknown what happens to the length of the clavicle within the first weeks after a fracture...
November 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29165556/resumption-of-oral-anticoagulation-following-traumatic-injury-and-risk-of-stroke-and-bleeding-in-patients-with-atrial-fibrillation-a-nationwide-cohort-study
#12
Laila Staerk, Emil Loldrup Fosbøl, Morten Lamberts, Anders Nissen Bonde, Kasper Gadsbøll, Caroline Sindet-Pedersen, Ellen A Holm, Thomas Alexander Gerds, Brice Ozenne, Gregory Y H Lip, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Jonas Bjerring Olesen
Aims: We examined the risks of all-cause mortality, stroke, major bleeding, and recurrent traumatic injury associated with resumption of vitamin K antagonists (VKAs) and non-VKAs oral anticoagulants (NOACs) following traumatic injury in atrial fibrillation (AF) patients. Methods and results: This was a Danish nationwide registry-based study (2005-16), including 4541 oral anticoagulant (OAC)-treated AF patients experiencing traumatic injury (defined as traumatic brain injury, hip fracture, or traumatic torso or abdominal injury)...
November 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29159953/relationship-between-heart-failure-concurrent-chronic-obstructive-pulmonary-disease-and-beta-blocker-use-a-danish-nationwide-cohort-study
#13
Maurizio Sessa, Annamaria Mascolo, Rikke Nørmark Mortensen, Mikkel Porsborg Andersen, Giuseppe Massimo Claudio Rosano, Annalisa Capuano, Francesco Rossi, Gunnar Gislason, Henrik Enghusen-Poulsen, Christian Torp-Pedersen
AIMS: To compare the hazard of all-cause, chronic obstructive pulmonary disease (COPD) and heart failure (HF) hospitalization in carvedilol vs. metoprolol/bisoprolol/nebivolol users with COPD and concurrent HF from 2009 to 2012, and to evaluate the use and persistence in treatment of these β-blockers, their impact on the risk of COPD-related hospitalization, and the factors important for their selection. METHODS AND RESULTS: Cox and logistic regression were used for both unadjusted and adjusted analyses...
November 20, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29157668/iron-induced-rna-oxidation-in-the-general-population-and-in-mouse-tissue
#14
Vanja Cejvanovic, Laura Kofoed Kjær, Helle Kirstine Mørup Bergholdt, Arendse Torp-Pedersen, Trine Henriksen, Allan Weimann, Christina Ellervik, Henrik Enghusen Poulsen
Iron promotes formation of hydroxyl radicals by the Fenton reaction, subsequently leading to potential oxidatively generated damage of nucleic acids. Oxidatively generated damage to RNA, measured as 8-oxo-7,8-dihydroguanosine (8-oxoGuo) in urine, is increased in patients with genetic iron overload, which have led us to test the hypothesis that high iron status, assessed by iron biomarkers and genetic disposition, increases urinary excretion of 8-oxoGuo. In a general Danish population study we used a Mendelian randomization design with HFE genotypes as a proxy for iron status and supplemented with ex vivo experiments in mice muscle tissue exposed to iron(II) sulfate to attempt to clarify this hypothesis...
November 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29148231/employment-status-at-time-of-first-hospitalization-for-heart-failure-is-associated-with-a-higher-risk-of-death-and-rehospitalization-for-heart-failure
#15
Rasmus Rørth, Emil L Fosbøl, Ulrik M Mogensen, Kristian Kragholm, Anna-Karin Numé, Gunnar H Gislason, Pardeep S Jhund, Mark C Petrie, John J V McMurray, Christian Torp-Pedersen, Lars Køber, Søren L Kristensen
AIMS: Employment status at time of first heart failure (HF) hospitalization may be an indicator of both self-perceived and objective health status. In this study, we examined the association between employment status and the risk of all-cause mortality and recurrent HF hospitalization in a nationwide cohort of patients with HF. METHODS AND RESULTS: We identified all patients of working age (18-60 years) with a first HF hospitalization in the period 1997-2015 in Denmark, categorized according to whether or not they were part of the workforce at time of the index admission...
November 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29145828/long-term-prognosis-of-patients-with-non-st-segment-elevation-myocardial-infarction-according-to-coronary-arteries-atherosclerosis-extent-on-coronary-angiography-a-historical-cohort-study
#16
Karam Sadoon Alzuhairi, Peter Søgaard, Jan Ravkilde, Aziza Azimi, Michael Mæng, Lisette Okkels Jensen, Christian Torp-Pedersen
BACKGROUND: Patients with non-ST-segment elevation myocardial infarction (NSTEMI) without obstructive coronary artery disease (CAD) are often managed differently than those with obstructive CAD, therefore we aimed in this study to examine the long-term prognosis of patients with NSTEMI according to the degree of CAD on coronary angiography (CAG). METHODS: We examined 8.889 consecutive patients admitted for first time NSTEMI during 2000-2011, to whom CAG was performed...
November 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29144161/use-of-patient-outcome-endpoints-to-identify-the-best-functional-ct-imaging-parameters-in-metastatic-renal-cell-carcinoma-patients
#17
Jill Rachel Mains, Frede Donskov, Erik Morre Petersen, Hans Henrik Torp Madsen, Jesper Thygesen, Kennet Thorup, Finn Rasmussen
OBJECTIVE: To use the patient outcome endpoints overall survival and progression-free survival to evaluate functional parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT). METHODS: 69 patients with metastatic renal cell carcinoma (mRCC) had DCE-CT scans at baseline and after 5 and 10 weeks of treatment. Blood volume, blood flow and standardized perfusion values were calculated using deconvolution (BVdeconv, BFdeconv and SPVdeconv), blood flow and standardized perfusion values using maximum slope (BFmax and SPVmax), and blood volume and permeability surface area product using the Patlak model (BVpatlak and PS)...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29132879/rivaroxaban-with-or-without-aspirin-in-patients-with-stable-coronary-artery-disease-an-international-randomised-double-blind-placebo-controlled-trial
#18
Stuart J Connolly, John W Eikelboom, Jackie Bosch, Gilles Dagenais, Leanne Dyal, Fernando Lanas, Kaj Metsarinne, Martin O'Donnell, Anthony L Dans, Jong-Won Ha, Alexandr N Parkhomenko, Alvaro A Avezum, Eva Lonn, Liu Lisheng, Christian Torp-Pedersen, Petr Widimsky, Aldo P Maggioni, Camilo Felix, Katalin Keltai, Masatsugu Hori, Khalid Yusoff, Tomasz J Guzik, Deepak L Bhatt, Kelley R H Branch, Nancy Cook Bruns, Scott D Berkowitz, Sonia S Anand, John D Varigos, Keith A A Fox, Salim Yusuf
BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29126266/non-insulin-antidiabetic-pharmacotherapy-in-patients-with-established-cardiovascular-disease-a-position-paper-of-the-european-society-of-cardiology-working-group-on-cardiovascular-pharmacotherapy
#19
Alexander Niessner, Juan Tamargo, Lorenz Koller, Christoph H Saely, Thomas Andersen Schmidt, Gianluigi Savarese, Sven Wassmann, Giuseppe Rosano, Claudio Ceconi, Christian Torp-Pedersen, Juan Carlos Kaski, Keld Per Kjeldsen, Stefan Agewall, Thomas Walther, Heinz Drexel, Basil S Lewis
No abstract text is available yet for this article.
November 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29116170/injection-of-high-dose-botulinum-toxin-a-leads-to-impaired-skeletal-muscle-function-and-damage-of-the-fibrilar-and-non-fibrilar-structures
#20
Jessica Pingel, Mikkel Schou Nielsen, Torsten Lauridsen, Kristian Rix, Martin Bech, Tine Alkjaer, Ida Torp Andersen, Jens Bo Nielsen, R Feidenhansl
Botulinum-toxin A (BoNT/A) is used for a wide range of conditions. Intramuscular administration of BoNT/A inhibits the release of acetylcholine at the neuromuscular junction from presynaptic motor neurons causing muscle-paralysis. The aim of the present study was to investigate the effect of high dose intramuscular BoNT/A injections (6 UI = 60 pg) on muscle tissue. The gait pattern of the rats was significantly affected 3 weeks after BoNT/A injection. The ankle joint rotated externally, the rats became flat footed, and the stride length decreased after BoNT/A injection...
November 7, 2017: Scientific Reports
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