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https://www.readbyqxmd.com/read/28087286/incidence-and-survival-outcome-according-to-heart-rhythm-during-resuscitation-attempt-in-out-of-hospital-cardiac-arrest-patients-with-presumed-cardiac-etiology
#1
Shahzleen Rajan, Fredrik Folke, Steen Møller Hansen, Carolina Malta Hansen, Kristian Kragholm, Thomas A Gerds, Freddy K Lippert, Lena Karlsson, Sidsel Møller, Lars Køber, Gunnar H Gislason, Christian Torp-Pedersen, Mads Wissenberg
BACKGROUND: Knowledge about heart rhythm conversion from non-shockable to shockable rhythm during resuscitation attempt after out-of-hospital cardiac arrest (OHCA) and following chance of survival is limited and inconsistent. METHODS: We studied 13,860 patients with presumed cardiac-caused OHCA not witnessed by the emergency medical services from the Danish Cardiac Arrest Register (2005-2012). Patients were stratified according to rhythm: shockable, converted shockable (based on receipt of subsequent defibrillation) and sustained non-shockable rhythm...
January 10, 2017: Resuscitation
https://www.readbyqxmd.com/read/28081252/corn-soy-blend-fortified-with-phosphorus-to-prevent-refeeding-hypophosphatemia-in-undernourished-piglets
#2
Anne-Louise Hother, Mikkel Lykke, Torben Martinussen, Hanne Damgaard Poulsen, Christian Mølgaard, Per Torp Sangild, André Briend, Christian Fink Hansen, Henrik Friis, Kim F Michaelsen, Thomas Thymann
BACKGROUND: Phosphorus (P) levels in refeeding diets are very important as undernourished children are at risk of hypophosphatemia during refeeding. For this reason, conventional corn-soy-blends (CSB) have been reformulated by the World Food Programme to obtain a mono-calcium-phosphate fortified product (CSB+) and a product further fortified with skim milk powder (CBS++). METHODS: Using a piglet model of undernourished children, we hypothesized that feeding of CSB+, CSB++ or CSB+ with added whey permeate (CSB+/wp) would help to prevent refeeding hypophosphatemia...
2017: PloS One
https://www.readbyqxmd.com/read/28077470/comprehensive-efforts-to-increase-adherence-to-statin-therapy
#3
REVIEW
Alexander Vonbank, Stefan Agewall, Keld Per Kjeldsen, Basil S Lewis, Christian Torp-Pedersen, Claudio Ceconi, Christian Funck-Brentano, Juan Carlos Kaski, Alexander Niessner, Juan Tamargo, Thomas Walther, Sven Wassmann, Giuseppe Rosano, Harald Schmidt, Christoph H Saely, Heinz Drexel
No abstract text is available yet for this article.
January 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28073883/infective-endocarditis-and-risk-of-death-after-cardiac-implantable-electronic-device-implantation-a-nationwide-cohort-study
#4
Cengiz Özcan, Jakob Raunsø, Morten Lamberts, Lars Køber, Tommi Bo Lindhardt, Niels Eske Bruun, Marie Louise Laursen, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Morten Lock Hansen
AIMS: To determine the incidence, risk factors, and mortality of infective endocarditis (IE) following implantation of a first-time, permanent, cardiac implantable electronic device (CIED). METHODS AND RESULTS: From Danish nationwide administrative registers (beginning in 1996), we identified all de-novo permanent pacemakers (PMs) and implantable cardioverter defibrillators (ICDs) together with the occurrence of post-implantation IE-events in the period from 2000-2012...
January 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28058848/implantable-cardioverter-defibrillator-and-survival-after-out-of-hospital-cardiac-arrest-due-to-acute-myocardial-infarction-in-denmark-in-the-years-2001-2012-a-nationwide-study
#5
Matilde Winther-Jensen, Jesper Kjaergaard, Jens F Lassen, Lars Køber, Christian Torp-Pedersen, Steen M Hansen, Freddy Lippert, Kristian Kragholm, Erika F Christensen, Christian Hassager
AIM: The purpose of this study was to describe the implantation of implantable cardioverter defibrillator after out-of-hospital cardiac arrest caused by myocardial infarction in Denmark 2001-2012 and subsequent survival. METHODS: The Danish Cardiac Arrest Registry was used to identify patients ⩾18 years surviving to discharge without prior implantable cardioverter defibrillator. Information on cardioverter defibrillator implantation was obtained from the National Patient Registry...
January 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28053276/the-risk-of-cardiovascular-morbidity-and-cardiovascular-mortality-in-systemic-lupus-erythematosus-and-lupus-nephritis-a-danish-nationwide-population-based-cohort-study
#6
Marie-Louise Hermansen, Jesper Lindhardsen, Christian Torp-Pedersen, Mikkel Faurschou, Søren Jacobsen
OBJECTIVE: To assess the role of LN as a risk factor for myocardial infarction (MI), stroke and cardiovascular mortality (CVM) in patients with SLE. METHODS: The study was conducted using individual-level data from multiple nationwide registers. We identified a cohort of patients diagnosed with SLE and further determined if they had a diagnosis of LN during 1995-2011. Each SLE patient was matched with five population controls. Hazard ratios (HRs) were calculated to measure the risk of MI, stroke and CVM in SLE patients relative to population controls and in SLE patients with relative to without LN...
January 3, 2017: Rheumatology
https://www.readbyqxmd.com/read/28042313/efficient-enhancement-of-blood-brain-barrier-permeability-using-acoustic-cluster-therapy-act
#7
Andreas K O Åslund, Sofie Snipstad, Andrew Healey, Svein Kvåle, Sverre H Torp, Per C Sontum, Catharina de Lange Davies, Annemieke van Wamel
The blood-brain barrier (BBB) is a major obstacle in drug delivery for diseases of the brain, and today there is no standardized route to surpass it. One technique to locally and transiently disrupt the BBB, is focused ultrasound in combination with gas-filled microbubbles. However, the microbubbles used are typically developed for ultrasound imaging, not BBB disruption. Here we describe efficient opening of the BBB using the promising novel Acoustic Cluster Therapy (ACT), that recently has been used in combination with Abraxane® to successfully treat subcutaneous tumors of human prostate adenocarcinoma in mice...
2017: Theranostics
https://www.readbyqxmd.com/read/28041549/-cardiovascular-risks-of-non-steroidal-anti-inflammatory-drugs-treatment
#8
Morten Schmidt, Emil Loldrup Fosbøl, Christian Torp-Pedersen, Anne-Marie Schjerning Olsen, Bo Christensen, Gunnar H Gislason
Non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs. Current evidence supports that all NSAIDs increase the risk of heart failure and elevate blood pressure, whereas the risk of thrombotic events varies with the type of drug. Use of newer selective cyclooxygenase-2 inhibitors has been associated with a substantial vascular risk but increasing concern also relates to traditional NSAIDs, in particular diclofenac. This review summarizes the current evidence regarding the cardiovascular safety of NSAIDs and presents recommendations for their use...
December 26, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28028073/thiazolidinediones-are-associated-with-a-decreased-risk-of-atrial-fibrillation-compared-with-other-antidiabetic-treatment-a-nationwide-cohort-study
#9
Jannik Langtved Pallisgaard, Tommi Bo Lindhardt, Laila Staerk, Jonas Bjerring Olesen, Christian Torp-Pedersen, Morten Lock Hansen, Gunnar Hilmar Gislason
AIM: The aim of this study was to investigate the association between thiazolidinediones (TZDs) vs. other antidiabetic drugs and risk of atrial fibrillation (AF) in diabetic patients. METHOD AND RESULTS: Diabetes mellitus (diabetes) increases the risk of AF by approximately 34%. TZD is an insulin sensitizer that also has anti-inflammatory effects, which might decrease the risk of AF compared with other antidiabetic drugs. We used data from the Danish nationwide registries to study 108 624 patients with diabetes and without prior AF who were treated with metformin or sulfonylurea as first-line drugs...
November 8, 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28025840/long-term-outcome-of-infliximab-treatment-in-chronic-active-ulcerative-colitis-a-swedish-multicentre-study-of-250-patients
#10
L Angelison, S Almer, A Eriksson, P Karling, U Fagerberg, J Halfvarson, M Thörn, J Björk, U Hindorf, R Löfberg, A Bajor, H Hjortswang, P Hammarlund, O Grip, J Torp, J Marsal, E Hertervig
BACKGROUND: Real-life long-term data on infliximab treatment in ulcerative colitis are limited. AIM: To study the long-term efficacy and safety of infliximab in chronic active ulcerative colitis and possible predictors of colectomy and response were also examined. METHODS: A retrospective multi-centre study of infliximab treatment in 250 patients with chronic active ulcerative colitis with inclusion criteria: age ≥18 years, ambulatory treated, steroid-dependent or intolerant and/or immunomodulator refractory or intolerant...
December 27, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28025218/non-steroidal-anti-inflammatory-drug-use-is-associated-with-increased-risk-of-out-of-hospital-cardiac-arrest-a-nationwide-case-time-control-study
#11
Kathrine B Sondergaard, Peter Weeke, Mads Wissenberg, Anne-Marie Schjerning Olsen, Emil L Fosbol, Freddy K Lippert, Christian Torp-Pedersen, Gunnar H Gislason, Fredrik Folke
AIMS: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and have been associated with increased cardiovascular risk. Nonetheless, it remains unknown whether use of NSAIDs is associated with out-of-hospital cardiac arrest (OHCA). METHODS AND RESULTS: From the nationwide Danish Cardiac Arrest Registry, all persons with OHCA during 2001-2010 were identified. NSAID use 30 days before OHCA was categorized as follows: diclofenac, naproxen, ibuprofen, rofecoxib, celecoxib, and other...
December 26, 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28002198/relation-between-weight-loss-and-causes-of-death-in-patients-with-cardiovascular-disease-finding-from-the-scout-trial
#12
Aldo P Maggioni, Ian D Caterson, Renato Urso, Walmir Coutinho, Nick Finer, Luc Van Gaal, Udo F Legler, Arya M Sharma, Radhika V Seimon, Arianne Sweeting, Christian Torp-Pedersen, William Philip T James
AIMS: Obesity is associated with an increased incidence of mortality. The Sibutramine Cardiovascular Outcomes (SCOUT) trial can provide the first evidence of the effect of intentional weight loss on mortality in an obese population at high risk. METHODS: SCOUT was a randomized, double-blind, placebo-controlled trial testing sibutramine vs. placebo. Eligibility for the trial required both men and women aged at least 55 years, with BMI of at least 27 kg/m and 45 kg/m or less...
December 19, 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/27981426/erratum-to-return-to-work-among-self-employed-cancer-survivors
#13
Steffen Torp, Jonn Syse, Alain Paraponaris, Sævar Gudbergsson
No abstract text is available yet for this article.
December 15, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27968805/vectorcardiographic-quantification-of-early-repolarization
#14
P L Soerensen, K Soerensen, J Melgaard, J J Struijk, S M Hansen, J K Kanters, J B Nielsen, J H Svendsen, S Haunsoe, L Koeber, A G Holst, A Pietersen, C Torp-Pedersen, F K Lippert, C Graff
No abstract text is available yet for this article.
November 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27932365/danish-register-based-study-on-the-association-between-specific-antipsychotic-drugs-and-fractures-in-elderly-individuals
#15
Maia Torstensson, Katja Leth-Møller, Charlotte Andersson, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Ellen Astrid Holm
BACKGROUND: antipsychotic drugs (APs) have been associated with falls and fractures in elderly individuals but limited knowledge on specific drugs exist. OBJECTIVE: to investigate the association between individual APs and fractures in elderly persons. DESIGN AND SETTING: nationwide register-based cohort study. SUBJECTS: all Danish individuals aged ≥65 who had not been in treatment with any AP in the year before inclusion...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27920127/antihypertensive-medication-postpones-the-onset-of-glaucoma-evidence-from-a-nationwide-study
#16
Anna Horwitz, Marc Klemp, Jørgen Jeppesen, James C Tsai, Christian Torp-Pedersen, Miriam Kolko
The aim was to investigate the impact of antihypertensive medication on the onset of glaucoma. Data from the complete Danish population between 40 and 95 years of age were used in the period from 1996 to 2012, covering >2.6 million individuals. The National Danish Registry of Medicinal Products Statistics was used to identify all claimed prescriptions for glaucoma medication and antihypertensive drugs. We first investigated basic correlations in the data and found that patients treated with antihypertensive medication, at any time during the study period, had a significantly higher overall relative risk (RR) of glaucoma, even when controlling for age and sex (with a RR of 1...
December 5, 2016: Hypertension
https://www.readbyqxmd.com/read/27904986/a-qualitative-study-of-clinicians-experience-with-rating-of-the-global-assessment-of-functioning-gaf-scale
#17
I H Monrad Aas, Ove Sonesson, Steffen Torp
The severity of illness in psychiatry is rated using the Global Assessment of Functioning (GAF) scale. The GAF scale is often used in both research settings and in the clinic. The scale ranges from 1 to 100 and is subdivided into ten 10-point intervals, each with verbal rating instructions called anchor points and examples. GAF is an instrument that needs improvement. Studying clinicians' experiences with this rating system may be important for developing improvements. The aim of this study was to collect information from clinicians about their experiences with the GAF instrument, and to collect their ideas on how the GAF scale can be improved, particularly in the area of verbal instructions (i...
November 30, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27894275/perceived-stress-as-a-risk-factor-for-peptic-ulcers-a-register-based-cohort-study
#18
Ulrik Deding, Linda Ejlskov, Mads Phillip Kofoed Grabas, Berit Jamie Nielsen, Christian Torp-Pedersen, Henrik Bøggild
BACKGROUND: The association between stress and peptic ulcers has been questioned since the discovery of helicobacter pylori. This study examined whether high perceived everyday life stress was associated with an increased risk of either receiving a triple treatment or being diagnosed with a peptic ulcer. METHODS: Cohen's perceived stress scale measured the level of stress in a general health survey in 2010 of 17,525 residents of northern Jutland, Denmark, and was linked with National Danish registers on prescription drugs and hospital diagnoses...
November 28, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27881566/association-of-bystander-cardiopulmonary-resuscitation-and-survival-according-to-ambulance-response-times-after-out-of-hospital-cardiac-arrest
#19
Shahzleen Rajan, Mads Wissenberg, Fredrik Folke, Steen Møller Hansen, Thomas A Gerds, Kristian Kragholm, Carolina Malta Hansen, Lena Karlsson, Freddy K Lippert, Lars Køber, Gunnar H Gislason, Christian Torp-Pedersen
BACKGROUND: Bystander-initiated cardiopulmonary resuscitation (CPR) increases patient survival after out-of-hospital cardiac arrest, but it is unknown to what degree bystander CPR remains positively associated with survival with increasing time to potential defibrillation. The main objective was to examine the association of bystander CPR with survival as time to advanced treatment increases. METHODS: We studied 7623 out-of-hospital cardiac arrest patients between 2005 and 2011, identified through the nationwide Danish Cardiac Arrest Registry...
December 20, 2016: Circulation
https://www.readbyqxmd.com/read/27877035/association-between-hemoglobin-and-prognosis-in-patients-admitted-to-hospital-for-copd
#20
Anne Pernille Toft-Petersen, Christian Torp-Pedersen, Ulla Møller Weinreich, Bodil Steen Rasmussen
Low concentrations of hemoglobin have previously been demonstrated in many patients with COPD. There is evidence of anemia as a prognostic factor in acute exacerbations, but the detailed relationship between concentrations of hemoglobin and mortality is not known. A register-based cohort of patients admitted for the first time to Danish hospitals for acute exacerbations of COPD from 2007 through 2012 was established. Age, sex, comorbidities, medication, renal function, and concentrations of hemoglobin were retrieved...
2016: International Journal of Chronic Obstructive Pulmonary Disease
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