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https://www.readbyqxmd.com/read/29165669/clinvar-improving-access-to-variant-interpretations-and-supporting-evidence
#1
Melissa J Landrum, Jennifer M Lee, Mark Benson, Garth R Brown, Chen Chao, Shanmuga Chitipiralla, Baoshan Gu, Jennifer Hart, Douglas Hoffman, Wonhee Jang, Karen Karapetyan, Kenneth Katz, Chunlei Liu, Zenith Maddipatla, Adriana Malheiro, Kurt McDaniel, Michael Ovetsky, George Riley, George Zhou, J Bradley Holmes, Brandi L Kattman, Donna R Maglott
ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/) is a freely available, public archive of human genetic variants and interpretations of their significance to disease, maintained at the National Institutes of Health. Interpretations of the clinical significance of variants are submitted by clinical testing laboratories, research laboratories, expert panels and other groups. ClinVar aggregates data by variant-disease pairs, and by variant (or set of variants). Data aggregated by variant are accessible on the website, in an improved set of variant call format files and as a new comprehensive XML report...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29164376/evaluation-of-quality-of-life-in-caregivers-who-are-providing-home-care-to-cancer-patients
#2
Mahcube Cubukcu
PURPOSE: The author aimed to evaluate the quality of life and the factors affecting the caregivers of cancer patients receiving home care. METHODS: This cross-sectional descriptive study was performed in 48 cancer patients who were served from home care unit and 48 caregivers between 01 and 28 February 2014. Patients' functional status was evaluated with Katz Index for Activities of Daily Living and the Lawton Scale for Instrumental Activities of Daily Living. The levels of quality of life of caregivers of patients with cancer were determined with Caregiver Quality of Life Index-Cancer (CQOLC)...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29162472/-self-perception-of-disease-in-patients-with-chronic-diseases
#3
L Adrián-Arrieta, J M Casas-Fernández de Tejerina
OBJECTIVE: The aim of this study is to assess the self-perception of disease by patients with chronic diseases and determine factors related to their perception of disease. MATERIAL AND METHODS: Cross-sectional descriptive study performed between September 2014 and April 2015 in nine (6 urban and 3 rural) Health Centres of Navarra, Spain. The participants were recruited by convenience sampling of 196 patients aged over 65 years with at least one chronic disease...
November 18, 2017: Semergen
https://www.readbyqxmd.com/read/29152425/stereotactic-body-radiotherapy-for-low-risk-prostate-cancer-a-ten-year-analysis
#4
Alan Katz
Objective This study represents the first 10 year analysis of the efficacy and toxicity of stereotactic body radiotherapy (SBRT) in the treatment of early low-risk prostate cancer. Materials and methods Two hundred and thirty males were treated with Cyberknife SBRT to a dose of 35 Gray (Gy) or 36.25 Gy in five consecutive days. All patients had a Gleason score of six and a PSA < 10ng/ml. Median follow-up is nine years. The median age was 69.5 years and median prostate specific antigen (PSA) was 5.6ng/ml...
September 9, 2017: Curēus
https://www.readbyqxmd.com/read/29149380/psa-kinetics-following-primary-focal-cryotherapy-hemiablation-in-organ-confined-prostate-cancer-patients
#5
Michael Kongnyuy, Shahidul Islam, Alfred K Mbah, Daniel M Halpern, Glenn T Werneburg, Kaitlin E Kosinski, Connie Chen, David J Habibian, Jeffrey T Schiff, Anthony T Corcoran, Aaron E Katz
PURPOSE: We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients. MATERIALS AND METHODS: This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Biochemical recurrence (BCR) was determined using the Phoenix criteria. PSA bounce was also assessed. We analyzed rates of change of PSA over time of post-PFC between BCR and no BCR groups...
November 17, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29144733/a-mechanism-for-symmetry-breaking-and-shape-control-in-single-crystal-gold-nanorods
#6
Michael J Walsh, Wenming Tong, Hadas Katz-Boon, Paul Mulvaney, Joanne Etheridge, Alison M Funston
The phenomenon of symmetry breaking-in which the order of symmetry of a system is reduced despite manifest higher-order symmetry in the underlying fundamental laws-is pervasive throughout science and nature, playing a critical role in fields ranging from particle physics and quantum theory to cosmology and general relativity. For the growth of crystals, symmetry breaking is the crucial step required to generate a macroscopic shape that has fewer symmetry elements than the unit cell and/or seed crystal from which it grew...
November 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29135785/comparison-of-polar-m600-optical-heart-rate-and-ecg-heart-rate-during-exercise
#7
John F Horton, Pro Stergiou, Tak S Fung, Larry Katz
PURPOSE: The purpose of this study was to evaluate the accuracy of the Polar M600 optical heart rate (OHR) sensor compared with ECG heart rate (HR) measurement during various physical activities. METHODS: Thirty-six subjects participated in a continuous 76-min testing session, which included rest, cycling warm-up, cycling intervals, circuit weight training, treadmill intervals, and recovery. HR was measured using a three-lead ECG configuration and a Polar M600 Sport Watch on the left wrist...
December 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29125982/disability-in-activities-of-daily-living-among-adults-with-cancer-a-systematic-review-and-meta-analysis
#8
REVIEW
Josephine Neo, Lucy Fettes, Wei Gao, Irene J Higginson, Matthew Maddocks
INTRODUCTION: People with cancer frequently report limitation in Activities of Daily Living (ADLs); essential activities required to live independently within society. Although several studies have assessed ADL related disability, variability in assessment, setting, and population means evidence is difficult to interpret. We aimed to determine the prevalence of ADL related disability, overall and by setting, and the most commonly affected ADLs in people living with cancer. METHODS: We searched twelve databases to June 2016 for observational studies assessing ADL disability in adults with cancer...
October 28, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29117418/keratoconus-screening-with-dynamic-biomechanical-in-vivo-scheimpflug-analyses-a-proof-of-concept-study
#9
Johannes Steinberg, Nazanin Eslami Amirabadi, Andreas Frings, Juliane Mehlan, Toam Katz, Stephan J Linke
PURPOSE: This proof-of-concept study was designed to analyze the ability of in vivo biomechanical corneal analyses with the corneal visualization Scheimpflug technology (CorvisST; Oculus Optikgeräte, Wetzlar, Germany) to differentiate between normal eyes and eyes with manifest keratoconus after strictly eliminating the potential confounding factors intraocular pressure (IOP) and central corneal thickness (CCT). METHODS: In this retrospective, cross-sectional study, after pairwise matching for CCT and IOP, 29 normal eyes and 29 keratoconic eyes (one eye from each patient) were selected as study population...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29106028/association-of-high-anti-cyclic-citrullinated-peptide-seropositivity-and%C3%A2-lean-mass-index-with-low-bone-mineral-density-in-rheumatoid-arthritis
#10
Katherine D Wysham, Dolores M Shoback, John B Imboden, Patricia P Katz
OBJECTIVE: Osteoporotic fractures are associated with high morbidity and mortality. Persons with rheumatoid arthritis (RA) have twice the risk of osteoporosis-related fracture than age-matched controls, the causes for which remain unknown. We investigated contributions of RA characteristics, medication use, and body composition to low bone mineral density (BMD) in patients with RA. METHODS: Data were from the Arthritis, Body Composition, and Disability Study (n=138; 82 women, 56 men)...
November 5, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29095855/impaired-memory-consolidation-in-children-with-obstructive-sleep-disordered-breathing
#11
Kiran Maski, Erin Steinhart, Hannah Holbrook, Eliot S Katz, Kush Kapur, Robert Stickgold
Memory consolidation is stabilized and even enhanced by sleep (and particularly by 12-15 Hz sleep spindles in NREM stage 2 sleep) in healthy children but it is unclear what happens to these processes when sleep is disturbed by obstructive sleep disordered breathing. This cross-sectional study investigates differences in declarative memory consolidation among children with primary snoring (PS) and obstructive sleep apnea (OSA) compared to controls. We further investigate whether memory consolidation group differences are associated with NREM stage 2 (N2) sigma (12-15 Hz) or NREM slow oscillation (0...
2017: PloS One
https://www.readbyqxmd.com/read/29053193/body-mass-index-at-adolescence-and-risk-of-noncardia-gastric-cancer-in-a-cohort-of-1-79-million-men-and-women
#12
Zohar Levi, Jeremy D Kark, Gilad Twig, Lior Katz, Adi Leiba, Estela Derazne, Dorit Tzur, Irena Liphshitz, Lital Keinan-Boker, Arnon Afek
BACKGROUND: This study assessed adolescent predictors of noncardia gastric cancer (NCGC) with a focus on the body mass index (BMI) in late adolescence. METHODS: This study analyzed a cohort of 1,087,358 Israeli Jewish males and 707,212 Israeli Jewish females who underwent a compulsory physical examination between the ages of 16 and 19 years from 1967 to 2002. By linkage to the national cancer registry, participants were followed for NCGC through December 31, 2012...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29032886/prevalence-and-risk-factors-for-paroxysmal-atrial-fibrillation-and-flutter-detection-after-cryptogenic-ischemic-stroke
#13
Claire Carrazco, Daniel Golyan, Michael Kahen, Karen Black, Richard B Libman, Jeffrey M Katz
INTRODUCTION: Long-term cardiac monitoring with implantable loop recorders (ILRs) has revealed occult paroxysmal atrial fibrillation and flutter (PAF) in a substantial minority of cryptogenic ischemic stroke (CIS) patients. Herein, we aim to define the prevalence, clinical relevance, and risk factors for PAF detection following early poststroke ILR implantation. MATERIALS AND METHODS: A retrospective study of CIS patients (n = 100, mean age 65.8 years; 52.5% female) who underwent ILR insertion during, or soon after, index stroke admission...
October 9, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29032225/right-ventricular-dysfunction-in-acute-myocardial-infarction-complicated-by-cardiogenic-shock-a-hemodynamic-analysis-of-the-should-we-emergently-revascularize-occluded-coronaries-for-cardiogenic-shock-shock-trial-and-registry
#14
Anuradha Lala, Yu Guo, Jinfeng Xu, Michele Esposito, Kevin Morine, Richard Karas, Stuart D Katz, Judith S Hochman, Daniel Burkhoff, Navin K Kapur
BACKGROUND: The prevalence and significance of right ventricular dysfunction (RVD) in patients with cardiogenic shock due to acute myocardial infarction (AMI-CS) has not been well characterized. We hypothesized that RVD is common in AMI-CS and associated with worse clinical outcomes. METHODS AND RESULTS: We retrospectively analyzed patients with available hemodynamics enrolled in the SHould we emergently revascularize Occluded coronaries for Cardiogenic shocK (SHOCK) Trial (n=139) and Registry (n=258) to identify RVD in AMI-CS...
October 11, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29027646/prevalence-of-obstructive-sleep-apnea-among-obese-toddlers-and-preschool-children
#15
Saadoun Bin-Hasan, Sherri Katz, Zoe Nugent, Joy Nehme, Zihang Lu, Abdullah Khayat, Suhail Al-Saleh, Reshma Amin, Indra Narang
BACKGROUND: Obstructive sleep apnea (OSA) is a common disorder estimated at 1-5% in the school-aged children. With the obesity prevalence reaching staggering rates globally, OSA in obese adolescents is estimated to be 4-5-folds higher than their lean peers. There is a paucity of data regarding obesity-related OSA in children 6 years and less. This is particularly relevant as OSA is associated with neurocognitive deficits. The aim of this study is to evaluate the prevalence of OSA among obese toddlers and preschool children and further to determine what other factors may be associated with the presence of OSA...
October 13, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29016508/prophylactic-negative-pressure-wound-therapy-for-obese-women-after-cesarean-delivery-a-systematic-review-and-meta-analysis
#16
REVIEW
Marcela C Smid, Sarah K Dotters-Katz, Matthew Grace, Sarah T Wright, Margaret S Villers, Abbey Hardy-Fairbanks, David M Stamilio
OBJECTIVE: To summarize available studies on wound complication outcomes after prophylactic negative pressure wound therapy for obese women (body mass index 30 or greater). DATA SOURCES: We conducted a systematic review and meta-analysis using electronic database search (PubMed, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Google scholar, and Web of Science), Cochrane, and trial registries including ClinicalTrials.gov. METHODS OF STUDY SELECTION: We conducted an electronic search of research articles from 1966 to January 2017 for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies of negative pressure wound therapy compared with standard dressing after cesarean delivery among obese women...
November 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28976450/exposure-to-simulated-mortality-affects-resident-performance-during-assessment-scenarios
#17
Andrew Goldberg, Stefan Samuelson, Yury Khelemsky, Daniel Katz, Alan Weinberg, Adam Levine, Samuel Demaria
BACKGROUND: The utility of simulated mortality remains controversial in the literature. We therefore sought primarily to determine whether there was a difference in performance for residents exposed to varying levels of simulated mortality during training scenarios. As a secondary objective, we also sought to determine whether their self-reported anxiety levels, attitudes toward, and engagement in the simulated encounters differed based on group assignment. METHODS: Fifty junior anesthesiology residents were randomized to one of the three simulation cohorts...
October 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28972967/ex-vivo-metabolic-fingerprinting-identifies-biomarkers-predictive-of-prostate-cancer-recurrence-following-radical-prostatectomy
#18
Peder R Braadland, Guro Giskeødegård, Elise Sandsmark, Helena Bertilsson, Leslie R Euceda, Ailin F Hansen, Ingrid J Guldvik, Kirsten M Selnæs, Helene H Grytli, Betina Katz, Aud Svindland, Tone F Bathen, Lars M Eri, Ståle Nygård, Viktor Berge, Kristin A Taskén, May-Britt Tessem
BACKGROUND: Robust biomarkers that identify prostate cancer patients with high risk of recurrence will improve personalised cancer care. In this study, we investigated whether tissue metabolites detectable by high-resolution magic angle spinning magnetic resonance spectroscopy (HR-MAS MRS) were associated with recurrence following radical prostatectomy. METHODS: We performed a retrospective ex vivo study using HR-MAS MRS on tissue samples from 110 radical prostatectomy specimens obtained from three different Norwegian cohorts collected between 2002 and 2010...
October 3, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28972242/disability-in-the-individual-adl-iadl-and-mobility-among-older-adults-a-prospective-cohort-study
#19
N Bleijenberg, N P A Zuithoff, A K Smith, N J de Wit, M J Schuurmans
OBJECTIVES: To examine the risk of disability in 15 individual ADL, IADL, and mobility in older adults by age; and to assess the association of multimorbidity, gender, and education with disability. DESIGN AND SETTING: A prospective cohort study. The sample included 805 community-dwelling older people aged 60+ living in the Netherlands. MEASUREMENTS: Disability was assessed using the Katz-15 Index of Independence in Basic Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL) and one mobility item...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28970276/outcomes-of-persistent-pulmonary-hypertension-following-transcatheter-aortic-valve-replacement
#20
Ahmad Masri, Islam Abdelkarim, Michael S Sharbaugh, Andrew D Althouse, Jeffrey Xu, Wei Han, Stephen Y Chan, William E Katz, Frederick W Crock, Matthew E Harinstein, Dustin E Kliner, Forozan Navid, Joon S Lee, Thomas G Gleason, John T Schindler, João L Cavalcante
OBJECTIVES: To determine the prevalence and factors associated with persistent pulmonary hypertension (PH) following transcatheter aortic valve replacement (TAVR) and its relationship with long-term mortality. METHODS: Consecutive patients who underwent TAVR from July 2011 through January 2016 were studied. The prevalence of baseline PH (mean pulmonary artery pressure ≥25 mm Hg on right heart catheterisation) and the prevalence and the predictors of persistent≥moderate PH (pulmonary artery systolic pressure (PASP)>45 mm Hg on 1 month post-TAVR transthoracic Doppler echocardiography) were collected...
September 29, 2017: Heart: Official Journal of the British Cardiac Society
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