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https://www.readbyqxmd.com/read/28050766/selective-perioperative-administration-of-pasireotide-is-more-cost-effective-than-routine-administration-for-pancreatic-fistula-prophylaxis
#1
Jason W Denbo, Rebecca S Slack, Morgan Bruno, Jordan M Cloyd, Laura Prakash, Jason B Fleming, Michael P Kim, Thomas A Aloia, Jean-Nicolas Vauthey, Jeffrey E Lee, Matthew H G Katz
BACKGROUND: In a randomized trial, pasireotide significantly decreased the incidence and severity of postoperative pancreatic fistula (POPF). Subsequent analyses concluded that its routine use is cost-effective. We hypothesized that selective administration of the drug to patients at high risk for POPF would be more cost-effective. STUDY DESIGN: Consecutive patients who did not receive pasireotide and underwent pancreatoduodenectomy (PD) or distal pancreatectomy (DP) between July 2011 and January 2014 were distributed into groups based on their risk of POPF using a multivariate recursive partitioning regression tree analysis (RPA) of preoperative clinical factors...
January 3, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28043939/associations-among-meniscal-damage-meniscal-symptoms-and-knee-pain-severity
#2
Lindsey A MacFarlane, Heidi Yang, Jamie E Collins, Ali Guermazi, Morgan H Jones, Erin Teeple, Li Xu, Elena Losina, Jeffrey N Katz
OBJECTIVE: Meniscal tears occur frequently in patients with knee osteoarthritis (OA). The aim of our study was to determine whether meniscal damage identified on magnetic resonance imaging (MRI) is associated with the severity of knee pain or the frequency of meniscal symptoms in patients with knee OA. METHODS: We performed a cross-sectional study using data from the Meniscal Tear in Osteoarthritis Research (MeTeOR) trial. We characterized meniscal damage hierarchically as: root tear; maceration; long and short complex or horizontal tears; and simple tears...
December 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28029539/disordered-weight-management-behaviors-nonprescription-steroid-use-and-weight-perception-in-transgender-youth
#3
Carly E Guss, David N Williams, Sari L Reisner, S Bryn Austin, Sabra L Katz-Wise
PURPOSE: Disordered weight management behaviors are prevalent among youth; recent case reports suggested that these behaviors might also be common in transgender youth. We studied associations of gender identity with disordered weight management behaviors, nonprescription steroid use, and weight perception among transgender and cisgender (nontransgender) high-school students in Massachusetts. METHODS: Data were analyzed from the 2013 Massachusetts Youth Health Survey, an anonymous survey in a random sample of Massachusetts public high schools...
October 28, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28009788/effect-of-load-carriage-on-upper-limb-performance
#4
Amir Hadid, Inbar Katz, Tal Haker, Gabi Zeilig, Ruth Defrin, Yoram Epstein, Amit Gefen
: Carrying heavy backpacks are often associated with shoulder discomfort or pain, loss of sensorimotor functions, and brachial plexus injuries that might hamper performance. Based on previous research, the cause of these symptoms could be tissue deformations of the brachial plexus and the subclavian artery caused by the shoulder straps. PURPOSE: To evaluate the changes in the upper extremity hemodynamic and neural function, and to assess how they are associated with brachial plexus tissue deformation during heavy load carriage...
December 22, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27986621/the-association-of-pre-operative-body-pain-diagram-scores-with-pain-outcomes-following-total-knee-arthroplasty
#5
A J Dave, F Selzer, E Losina, I Usiskin, J E Collins, Y C Lee, P Band, D F Dalury, R Iorio, K Kindsfater, J N Katz
OBJECTIVE: Approximately 20% of total knee arthroplasty (TKA) recipients have suboptimal pain relief. We evaluated the association between pre-surgical widespread body pain and incomplete pain relief following TKA. METHOD: This prospective analysis included 241 patients with knee osteoarthritis (OA) undergoing unilateral TKA who completed questionnaires preoperatively and up to 12 months post-operatively. Questionnaires included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scale and a body pain diagram...
December 14, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27970007/tct-632-predictive-value-of-age-adjusted-charlson-comorbidity-index-for-1-year-3-year-and-5-year-mortality-in-patients-following-transcatheter-mitral-valve-repair
#6
Mike Saji, Marc Katz, Gorav Ailawadi, Dale Fowler, Damien LaPar, Leora Yarboro, Ravi Ghanta, John Kern, John Dent, Michael Ragosta, Scott Lim
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27959607/ustekinumab-as-induction-and-maintenance-therapy-for-crohn-s-disease
#7
RANDOMIZED CONTROLLED TRIAL
Brian G Feagan, William J Sandborn, Christopher Gasink, Douglas Jacobstein, Yinghua Lang, Joshua R Friedman, Marion A Blank, Jewel Johanns, Long-Long Gao, Ye Miao, Omoniyi J Adedokun, Bruce E Sands, Stephen B Hanauer, Severine Vermeire, Stephan Targan, Subrata Ghosh, Willem J de Villiers, Jean-Frédéric Colombel, Zsolt Tulassay, Ursula Seidler, Bruce A Salzberg, Pierre Desreumaux, Scott D Lee, Edward V Loftus, Levinus A Dieleman, Seymour Katz, Paul Rutgeerts
Background Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, was evaluated as an intravenous induction therapy in two populations with moderately to severely active Crohn's disease. Ustekinumab was also evaluated as subcutaneous maintenance therapy. Methods We randomly assigned patients to receive a single intravenous dose of ustekinumab (either 130 mg or approximately 6 mg per kilogram of body weight) or placebo in two induction trials. The UNITI-1 trial included 741 patients who met the criteria for primary or secondary nonresponse to tumor necrosis factor (TNF) antagonists or had unacceptable side effects...
November 17, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27943245/variability-of-delirium-motor-subtype-scale-defined-delirium-motor-subtypes-in-elderly-adults-with-hip-fracture-a-longitudinal-study
#8
Rikie M Scholtens, Barbara C van Munster, Dimitrios Adamis, Annemarieke de Jonghe, David J Meagher, Sophia E J A de Rooij
OBJECTIVES: To examine changes in motor subtype profile in individuals with delirium. DESIGN: Observational, longitudinal study; substudy of a multicenter, randomized controlled trial. SETTING: Departments of surgery and orthopedics, Academic Medical Center and Tergooi Hospital, the Netherlands. PARTICIPANTS: Elderly adults acutely admitted for hip fracture surgery who developed delirium according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, for 2 days or longer (n = 76, aged 86...
December 9, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27926573/further-delineation-between-typical-and-atypical-dopamine-uptake-inhibitors-effects-on-food-maintained-behavior-and-food-consumption
#9
Jonathan M Slezak, Rajeev I Desai, Jonathan L Katz
The present studies compared the acute effects of benztropine analogs (4-Cl-BZT, JHW 007, AHN 1-055), which are atypical dopamine uptake inhibitors, with those of the standard dopamine uptake inhibitors GBR 12909 and cocaine, on the reinforcing efficacy of food and food intake in male Sprague-Dawley rats. Repeated drug effects of JHW 007 on food intake were also determined. The number of ratios completed under a progressive-ratio schedule of food delivery was used as an index of reinforcing efficacy. Food intake was determined by measuring powdered laboratory-chow consumption during daily 40 min food-availability time periods...
February 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27923347/subjective-burden-among-spousal-and-adult-child-informal-caregivers-of-older-adults-results-from-a-longitudinal-cohort-study
#10
Marloes Oldenkamp, Mariët Hagedoorn, Joris Slaets, Ronald Stolk, Rafael Wittek, Nynke Smidt
BACKGROUND: Pressures on informal caregivers are likely to increase due to increasing life expectancy and health care costs, which stresses the importance of prevention of subjective burden. The present study examined the correlates of overall subjective burden and multiple burden dimensions among spousal and adult-child caregivers of Dutch older adults, both cross-sectional and longitudinal (12-months follow-up). METHODS: In 2010 and 2011 baseline and follow-up data was collected in a sample of informal caregivers and care recipients in the Northern provinces of the Netherlands...
December 7, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27919768/proximal-femoral-fractures-in-centenarians-a-retrospective-analysis-of-39-patients
#11
A Morice, N Reina, G Gracia, P Bonnevialle, J-M Laffosse, K Wytrykowski, E Cavaignac, N Bonnevialle
BACKGROUND: A corollary of the current population ageing in France is an increase in proximal femoral fractures (PFFs), particularly among centenarians. The outcomes of PFFs in centenarians in France are unknown. We therefore conducted a retrospective study of centenarians with PFFs both to assess: (1) assess clinical outcomes according to geriatric and trauma scores, (2) and to determine whether routine surgery is warranted. HYPOTHESIS: Morbidity and mortality in a single-centre cohort of centenarians with surgically treated PFFs are consistent with previous reports...
December 2, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27919767/internal-fixation-of-intra-capsular-proximal-femoral-fractures-in-patients-older-than-80-years-still-relevant-multivariate-analysis-of-a-prospective-multicentre-cohort
#12
N Reina, P Bonnevialle, B Rubens Duval, P Adam, F Loubignac, T Favier, P Massin
BACKGROUND: Arthroplasty is now widely used to treat intra-capsular proximal femoral fractures (PFFs) in older patients, even when there is little or no displacement. However, whether arthroplasty is associated with lower mortality and complication rates in non-displaced or mildly displaced PFFs is unknown. The objectives of this prospective study were: (1) to evaluate early mortality rates with the two treatment methods, (2) to identify risk factors for complications, (3) and to identify predictors of functional decline...
December 2, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27914495/quantitative-increase-in-frailty-is-associated-with-diminished-survival-after-transcatheter-aortic-valve-replacement
#13
Dhaval Chauhan, Nicky Haik, Aurelie Merlo, Bruce J Haik, Chunguang Chen, Marc Cohen, Anne Mosenthal, Mark Russo
BACKGROUND: The purpose of this study is to assess the impact of frailty index comprised of commonly used frailty metrics on outcomes following transcatheter aortic valve replacement (TAVR) outcomes, including mortality, length of stay, and discharge destination. METHODS AND RESULTS: Retrospective data collection was performed for 342 consecutive patients who underwent TAVR at a single center from May 15, 2012, to September 17, 2015. Frailty index score was calculated using 15-ft walk test, Katz activities of daily living, preoperative serum albumin, and dominant handgrip strength...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27913863/-multifocal-intraocular-lens-miol-surgery-in-young-non-presbyopic-ametropes-reasonable-and-safe
#14
A Frings, J Steinberg, S J Linke, V Druchkiv, T Katz
BACKGROUND: Refractive lens exchange and implantation of a multifocal intraocular lens (MIOL) is mainly advised for ametropes with presbyopia. Non-presbyopic young ametropes who wish spectacle-independence are usually treated with corneal refractive surgery or phakic lenses. OBJECTIVES: This retrospective case series aimed to analyse the refractive and subjective satisfaction outcome after MIOL surgery in both eyes of non-presbyopic ametropes where other treatment options were not possible...
December 2, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27902568/health-utilities-in-people-with-chronic-pain-using-a-population-level-survey-and-linked-health-care-administrative-data
#15
Mary-Ellen Hogan, Anna Taddio, Joel Katz, Vibhuti Shah, Murray Krahn
Health utilities are a preference-based measure of health-related quality of life that facilitates comparison of disease burden across conditions. We estimated utilities using a population-based, matched sample of adolescents and adults with and without chronic pain, controlling for comorbidity. Ontarians aged ≥12 years with and without chronic pain were identified from the Canadian Community Health Survey (CCHS) 2000-2001 and 2009-2010 and linked to their provincial health care administrative data. Individuals with chronic pain were matched to those without using age, sex, survey year, and a propensity score for having chronic pain estimated from a rurality index, income quintile, and comorbidity...
November 24, 2016: Pain
https://www.readbyqxmd.com/read/27896146/determination-of-functional-prognosis-in-hospitalized-patients-following-an-intensive-care-admission
#16
Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, George Ntoumenopoulos, Jerffesson Dias, Fernando S Guimaraes
AIM: To investigate the factors associated with the functional progress of hospitalized patients following an intensive care admission. METHODS: Retrospective study including data from a cohort of 198 hospitalized patients following an intensive care admission and not requiring mechanical ventilation in a single tertiary referral hospital. A generalized linear model was used to identify the main effects of clinical and demographic variables on the outcomes of functionality (KATZ Index of Independence in Activities of Daily Living) and muscle strength (MRC Scale)...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27855633/care-recipients-physical-frailty-is-independently-associated-with-subjective-burden-in-informal-caregivers-in-the-community-setting-a-cross-sectional-study
#17
Thom J Ringer, Afeez Abiola Hazzan, Courtney C Kennedy, Sarah Karampatos, Christopher Patterson, Sharon Marr, Brian Misiaszek, Tricia Woo, George Ioannidis, Alexandra Papaioannou
BACKGROUND: Physical frailty is associated with significant morbidity and mortality in community-dwelling older adults. Burden in informal caregivers of older adults causes significant physical and psychological distress. However, the relationship between these two clinical phenomena has not been extensively studied. This cross-sectional study evaluated the relationship between physical frailty of community-dwelling older adults attending an outpatient geriatric clinic and the subjective burden reported by their informal caregivers...
November 17, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27852905/predictors-and-outcomes-of-crossover-to-surgery-from-physical-therapy-for-meniscal-tear-and-osteoarthritis-a-randomized-trial-comparing-physical-therapy-and-surgery
#18
Jeffrey N Katz, John Wright, Kurt P Spindler, Lisa A Mandl, Clare E Safran-Norton, Emily K Reinke, Bruce A Levy, Rick W Wright, Morgan H Jones, Scott D Martin, Robert G Marx, Elena Losina
BACKGROUND: Arthroscopic partial meniscectomy (APM) combined with physical therapy (PT) have yielded pain relief similar to that provided by PT alone in randomized trials of subjects with a degenerative meniscal tear. However, many patients randomized to PT received APM before assessment of the primary outcome. We sought to identify factors associated with crossing over to APM and to compare pain relief between patients who had crossed over to APM and those who had been randomized to APM...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27849279/oral-health-status-and-functional-capacity-in-the-elderly-a-longitudinal-population-based-study
#19
Yan Nogueira Freitas, Kenio Costa Lima, Diviane Alves da Silva
Introduction: The study of oral health conditions and functional dependency in elderly people represents an important step toward the comprehension of the intervenient factors in the health care of this population. Purpose: This methodological note described strategies and methods adopted in a longitudinal study which has been analyzing the association of oral health conditions with functional dependence among the elderly population in a city located in the countryside of Northeastern Brazil...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/27843557/inclusion-of-walnut-in-the-diets-of-adults-at-risk-for-type-2-diabetes-and-their-dietary-pattern-changes-a-randomized-controlled-cross-over-trial
#20
Valentine Yanchou Njike, Niloufarsadat Yarandi, Paul Petraro, Rockiy G Ayettey, Judith A Treu, David L Katz
BACKGROUND: In our recently published study, including walnuts in the diets of adults with prediabetes led to overall improvement in diet quality. This report adds to those study findings by examining the food groups displaced during walnut inclusion in the diets of those adults with prediabetes. METHODS: Randomized, controlled, modified Latin square parallel design with 2 treatment arms. The 112 participants (31 men, 81 women) were randomly assigned to a diet with or without dietary counseling to regulate calorie intake in a 1:1 ratio...
2016: BMJ Open Diabetes Research & Care
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