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https://www.readbyqxmd.com/read/28803824/the-clinical-spectrum-of-hepatic-manifestations-in-chronic-lymphocytic-leukemia
#1
REVIEW
Natalia Kreiniz, Ofrat Beyar Katz, Aaron Polliack, Tamar Tadmor
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world, characterized by the presence of long-lived circulating leukemic cells in the peripheral blood that may infiltrate all organs, particularly those of the reticulo-endothelial system. Liver enlargement and elevation of liver enzymes related to specific involvement by the underlying disease are well-recognized features in these patients. In CLL, the differential diagnosis of liver disorders is broad and includes liver infiltration by leukemic cells, immunologic manifestations associated with CLL, primary and secondary hepatic malignancies, drug-induced hepatotoxicity, infections, and Richter transformation...
July 23, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28793114/elderly-who-take-care-of-elderly-a-study-on-the-frailty-syndrome
#2
Ariene Angelini Dos Santos-Orlandi, Tábatta Renata Pereira de Brito, Ana Carolina Ottaviani, Estefani Serafim Rossetti, Marisa Silvana Zazzetta, Sofia Cristina Iost Pavarini
Objective: Identifying prevalence of frailty in elderly caregivers inserted in a high social vulnerability context and its correlation with sociodemographic and health aspects. Method: Descriptive, correlational and cross-sectional study. Forty elderly caregivers were evaluated with: questionnaire for caregiver characterization, Mini Mental State Examination, Katz Index, Lawton instrumental activities of daily living scale, Geriatric Depression Scale and the frailty phenotype proposed by Fried...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28793099/factors-associated-with-the-functional-capacity-of-older-adults-with-leprosy
#3
Paula Sacha Frota Nogueira, Marilia Braga Marques, Janaina Fonseca Victor Coutinho, Juliana Cunha Maia, Maria Josefina da Silva, Escolástica Rejane Ferreira Moura
Objective: to investigate the association between socio-demographic and clinical factors and the functional capacity of older adults with leprosy. Method: cross-sectional analytical study conducted in Fortaleza, Ceará, Brazil, with 77 older adult patients with leprosy in a referral service, through interview, medical records and application of the Katz Index and the Lawton and Brody Scale. Results: the mean age was 68.23 years, with prevalence of men, in stable union/married, with mean monthly family income of 2...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28783470/differences-in-fitness-level-between-women-aged-60-and-over-participating-in-three-different-supervised-exercise-programs-and-a-sedentary-group
#4
Maria Viladrosa, Ana Lavedán, Pilar Jürschik, Sebastià Mas-Alòs, Antoni Planas-Anzano, Olga Masot
The aim of this study was to compare fitness levels in women aged 60 and over participating in a supervised exercise program (involving tai chi, recreational gymnastics, and/or aquatic fitness) with those in a sedentary group. An observational, descriptive, cross-sectional study was performed on a total of 171 women aged from 60 to 92 who attended public community clubs for older adults. The instruments used included the Senior Fitness Test, the Tinetti Balance Assessment Tool, the Katz Index, and the Lawton & Brody Activities of Daily Living Scale...
August 7, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28769587/health-care-resource-use-and-cost-differences-by-opioid-therapy-type-among-chronic-noncancer-pain-patients
#5
Pamela B Landsman-Blumberg, Nathaniel Katz, Kavita Gajria, Anna O D'Souza, Sham L Chaudhari, Paul P Yeung, Richard White
The study assessed 12-month chronic pain (CP)-related health care utilization and costs among chronic noncancer pain (CNCP) patients who initiated various long-term opioid treatments. Treatments included monotherapy with long-acting opioids (mono-LAOs), mono-therapy with short-acting opioids (mono-SAOs), both LAOs and SAOs (combination), and opioid therapy initiated with SAO or LAO and switched to the other class (switch). Using MarketScan(®) claims databases (2006-2012), we identified CNCP patients with ≥90 days opioid supply after pain diagnosis and continuous enrollment 12 months before pain diagnosis (baseline period) and 12 months after opioid start (post-index period)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28761662/which-foods-are-displaced-in-the-diets-of-adults-with-type-2-diabetes-with-the-inclusion-of-eggs-in-their-diets-a-randomized-controlled-crossover-trial
#6
Valentine Y Njike, Rachel Annam, Victoria Christina Costales, Niloufarsadat Yarandi, David L Katz
BACKGROUND: The inclusion or exclusion of specific foods from the overall diet inevitably affects other food choices, and this matter is routinely neglected in dietary guidance and nutritional epidemiology. We examined how the inclusion of eggs in the diets of type 2 diabetics affected dietary pattern. METHODS: Randomized, controlled, single-blind, crossover trial of 34 adults (mean age 64.5 years; 14 women, 20 men) with type 2 diabetes assigned to one of two possible sequence permutations of two different 12-week treatments (two eggs/day or egg exclusion), with 6-week washout periods...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28736986/adolescent-body-mass-index-and-risk-of-colon-and-rectal-cancer-in-a-cohort-of-1-79-million-israeli-men-and-women-a-population-based-study
#7
Zohar Levi, Jeremy D Kark, Lior H Katz, Gilad Twig, Estela Derazne, Dorit Tzur, Yaara Leibovici Weissman, Adi Leiba, Irena Lipshiez, Lital Keinan Boker, Arnon Afek
BACKGROUND: This study examined the association between the body mass index (BMI) in late adolescence and the risk of colon and rectal cancer. METHODS: This study analyzed a cohort of 1,087,358 Jewish men and 707,212 Jewish women who underwent health examinations at the ages of 16 to 19 years between 1967 and 2002 and were followed by linkage to the national cancer registry up to 2012. Cox regression was used to estimate hazard ratios (HRs) for cancer according to age- and sex-adjusted BMI percentiles from the US Centers for Disease Control and Prevention (overweight, 85th percentile to <95th percentile; obesity, ≥95th percentile)...
July 24, 2017: Cancer
https://www.readbyqxmd.com/read/28735906/predicting-the-presence-of-sleep-disordered-breathing-in-children-with-down-syndrome
#8
Joy Nehme, Robert LaBerge, Mary Pothos, Nick Barrowman, Lynda Hoey, Andrea Monsour, Madelaine Kukko, Sherri Lynne Katz
OBJECTIVE: Sleep-disordered breathing (SDB) is highly prevalent in children with Down syndrome. Given the scarcity of resources and the presence of risk factors for SDB in this population, the objective of this study is to identify the clinical predictors of SDB, which would assist prioritization of children with Down syndrome for SDB evaluation. METHODS: A retrospective cohort study was conducted on children enrolled in the Down syndrome clinic at CHEO who underwent polysomnography in 2004-2014...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28733181/caring-for-a-person-with-dementia-on-the-margins-of-long-term-care-a-perspective-on-burden-from-8-european-countries
#9
Caroline Sutcliffe, Clarissa Giebel, Michel Bleijlevens, Connie Lethin, Minna Stolt, Kai Saks, Maria E Soto, Gabriele Meyer, Adelaida Zabalegui, Helen Chester, David Challis
OBJECTIVES: To explore associations between carer burden and characteristics of (1) the informal carer, (2) the person with dementia, and (3) the care support network in 8 European countries. DESIGN: Cross-sectional study. SETTING: People with dementia judged at risk of admission to long-term care (LTC) facilities in 8 European countries (Estonia, Finland, France, Germany, Netherlands, Spain, Sweden, United Kingdom). PARTICIPANTS: A total of 1223 people with dementia supported by community services at home or receiving day care or respite care and their informal carers...
July 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28717815/hip-fractures-in-older-patients-trajectories-of-disability-after-surgery
#10
J J Aarden, M van der Esch, R H H Engelbert, M van der Schaaf, S E de Rooij, B M Buurman
BACKGROUND: Hip fracture in older patients often lead to permanent disabilities and can result in mortality. OBJECTIVE: To identify distinct disability trajectories from admission to one-year post-discharge in acutely hospitalized older patients after hip fracture. DESIGN: Prospective cohort study, with assessments at admission, three-months and one-year post-discharge. SETTING AND PARTICIPANTS: Patients ≥ 65 years admitted to a 1024-bed tertiary teaching hospital in the Netherlands...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28678924/persistent-depressive-symptoms-are-independent-predictors-of-low-grade-inflammation-onset-among-healthy-individuals
#11
Fábio Gazelato de Mello Franco, Antonio Gabriele Laurinavicius, Paulo A Lotufo, Raquel D Conceição, Fernando Morita, Marcelo Katz, Maurício Wajngarten, José Antonio Maluf Carvalho, Hayden B Bosworth, Raul Dias Santos
Background: Depressive symptoms are independently associated with an increased risk of cardiovascular disease (CVD) among individuals with non-diagnosed CVD. The mechanisms underlying this association, however, remain unclear. Inflammation has been indicated as a possible mechanistic link between depression and CVD. Objectives: This study evaluated the association between persistent depressive symptoms and the onset of low-grade inflammation. Methods: From a database of 1,508 young (mean age: 41 years) individuals with no CVD diagnosis who underwent at least two routine health evaluations, 134 had persistent depressive symptoms (Beck Depression Inventory - BDI ≥ 10, BDI+) and 1,374 had negative symptoms at both time points (BDI-)...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28675617/developing-a-practical-suicide-risk-prediction-model-for-targeting-high-risk-patients-in-the-veterans-health-administration
#12
Ronald C Kessler, Irving Hwang, Claire A Hoffmire, John F McCarthy, Maria V Petukhova, Anthony J Rosellini, Nancy A Sampson, Alexandra L Schneider, Paul A Bradley, Ira R Katz, Caitlin Thompson, Robert M Bossarte
OBJECTIVES: The US Veterans Health Administration (VHA) has begun using predictive modeling to identify Veterans at high suicide risk to target care. Initial analyses are reported here. METHODS: A penalized logistic regression model was compared with an earlier proof-of-concept logistic model. Exploratory analyses then considered commonly-used machine learning algorithms. Analyses were based on electronic medical records for all 6,360 individuals classified in the National Death Index as having died by suicide in fiscal years 2009-2011 who used VHA services the year of their death or prior year and a 1% probability sample of time-matched VHA service users alive at the index date (n = 2,112,008)...
July 4, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28651810/comparison-of-5468-retreatments-after-laser-in-situ-keratomileusis-by-lifting-the-flap-or-performing-photorefractive-keratectomy-on-the-flap
#13
J Ortega-Usobiaga, F Llovet-Osuna, T Katz, M R Djodeyre, V Druchkiv, R Bilbao-Calabuig, J Baviera
PURPOSE: To assess visual outcomes of retreatment after laser in situ keratomileusis (LASIK) by lifting the flap or performing photorefractive keratectomy (PRK) on the flap, as well as to establish whether there was an increased risk of epithelial ingrowth (EIG) when LASIK and lifting of the flap are separated by a long time interval and to determine the incidence of corneal haze after PRK. METHODS: Retrospective study of 4077 patients (5468 eyes) who underwent LASIK and subsequent retreatment were reviewed in order to study their visual results and identify cases of EIG and corneal haze...
June 23, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28651794/airflow-shape-is-associated-with-the-pharyngeal-structure-causing-osa
#14
Pedro R Genta, Scott A Sands, James P Butler, Stephen H Loring, Eliot S Katz, B Gail Demko, Eric J Kezirian, David P White, Andrew Wellman
BACKGROUND: OSA results from the collapse of different pharyngeal structures (soft palate, tongue, lateral walls, and epiglottis). The structure involved in collapse has been shown to impact non-CPAP OSA treatment. Different inspiratory airflow shapes are also observed among patients with OSA. We hypothesized that inspiratory flow shape reflects the underlying pharyngeal structure involved in airway collapse. METHODS: Subjects with OSA were studied with a pediatric endoscope and simultaneous nasal flow and pharyngeal pressure recordings during natural sleep...
June 23, 2017: Chest
https://www.readbyqxmd.com/read/28650247/burden-of-alcohol-abuse-or-dependence-among-long-term-opioid-users-with-chronic-noncancer-pain
#15
Pamela B Landsman-Blumberg, Nathaniel Katz, Kavita Gajria, Anna D Coutinho, Paul P Yeung, Richard White
BACKGROUND: Substance abuse disorders among chronic noncancer pain (CNCP) patients add to the clinical challenges and economic burden of caring for such patients. Despite potential risks, some CNCP patients with a history of alcohol abuse or dependence (AAD) and pain that is refractory to nonopioid treatment options may still need opioids for pain management. However, there is a lack of data on adverse outcomes in long-term opioid users with CNCP and a history of substance abuse or AAD disorders...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28623549/elevated-circulating-pcsk9-concentrations-predict-subclinical-atherosclerotic-changes-in-low-risk-obese-and-non-obese-patients
#16
Štefan Tóth, Ján Fedačko, Tímea Pekárová, Zdenka Hertelyová, Matan Katz, Adil Mughees, Jozef Kuzma, Peter Štefanič, Ivan Kopolovets, Daniel Pella
INTRODUCTION: Many studies have highlighted the important role of PCSK9 in the development of cardiometabolic changes and its possible function as a biomarker of myocardial infarction or ischemic heart disease. This study aimed to determine the relationship between circulating PCSK9 levels and subclinical vascular changes in the group of low risk patients without manifest cardiovascular diseases. METHODS: In this study, 120 healthy patients, free of manifest cardiovascular diseases, diabetes mellitus, and without lipid-lowering therapy, were divided into three groups based on BMI: normal weight (N = 50), overweight (N = 30), and obese (N = 40)...
June 16, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28617732/the-effects-of-latanoprost-with-benzalkonium-chloride-versus-travoprost-with-sofzia-on-the-ocular-surface
#17
Kamran Rahmatnejad, Christopher J Rapuano, Parul Ichhpujani, Sheryl S Wizov, Marlene R Moster, Lisa A Hark, L Jay Katz
PURPOSE: To assess ocular surface changes in participants using latanoprost with benzalkonium chloride (Xalatan) and travoprost with SofZia (Travatan Z). METHODS: In this prospective, open-label, nonrandomized cohort study, participants were classified into two groups: group 1 (n=28) naive to glaucoma therapy, group 2 (n=27) on previous Xalatan monotherapy in both eyes. Both groups started (or continued) Xalatan in the right eye and Travatan Z in the left eye. Baseline, 1-, and 2-month measurements of tear breakup time (TBUT), corneal staining score, conjunctival staining score, conjunctival hyperemia score, tear production, and intraocular pressure were obtained...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28614524/family-vulnerability-index-to-disability-and-dependence-fvi-dd-by-social-and-health-conditions
#18
Fernanda Amendola, Márcia Regina Martins Alvarenga, Maria do Rosário Dias de Oliveira Latorre, Maria Amélia de Campos Oliveira
The Family Vulnerability Index to Disability and Dependence (FVI-DD) aims to summarize the dimensions of vulnerability to disability and dependence using family data monitored by Family Health Strategy (ESF) teams. This study aims to analyze the FVI-DD according to the social and health vulnerability, to validate and extract a cutoff point for each dimension. The FVI-DD was built with a sample of 248 families living in a region of São Paulo. The dimension related to health conditions was validated with good internal consistency, with respect to the Katz Index and the Lawton Scale, whereas the dimension related to social conditions was only validated in relation to Lawton Scale...
June 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28591386/impact-of-insomnia-on-self-perceived-health-in-the-elderly
#19
Janiciene Silva, Annibal Truzzi, Fayanne Schaustz, Roberta Barros, Marisa Santos, Jerson Laks
Objective: To investigate the association between self-perceived health, and sociodemographic and clinical factors in a sample of elderly outpatients in Rio de Janeiro. Methods: A sample of 345 elderly patients was assessed with an anamnesis, Lawton and Brody's Scale, Katz Index, Geriatric Depression Scale, Timed Up and Go Test, and Study of Osteoporotic Fracture Index. Logistic regression analyses were performed to investigate the predictors of self-perceived health...
May 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28573369/systolic-and-pulse-pressure-associate-with-incident-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#20
Grace H Lo, Timothy E McAlindon, Jeffrey N Katz, Jeffrey B Driban, Lori Lyn Price, Charles B Eaton, Nancy J Petersen, Christie M Ballantyne, Maria E Suarez-Almazor
We evaluated the relationship of systolic blood pressure, diastolic blood pressure, pulse pressure, and treatment with antihypertensives with knee osteoarthritis incidence in a US cohort. We performed a longitudinal study (2004-2010) nested within the Osteoarthritis Initiative Study including only individuals without knee osteoarthritis at baseline. Systolic blood pressure, diastolic blood pressure, and pulse pressure were assessed at baseline, 12-, 24-, and 36-month visits. Knee radiographs at baseline, 12-, 24-, 36- and 48-month visits defined radiographic osteoarthritis, Kellgren and Lawrence grade ≥2...
June 1, 2017: Clinical Rheumatology
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