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https://www.readbyqxmd.com/read/27919768/proximal-femoral-fractures-in-centenarians-a-retrospective-analysis-of-39-patients
#1
A Morice, N Reina, G Gracia, P Bonnevialle, J-M Laffosse, K Wytrykowski, E Cavaignac, N Bonnevialle
BACKGROUND: A corollary of the current population ageing in France is an increase in proximal femoral fractures (PFFs), particularly among centenarians. The outcomes of PFF in centenarians in France are unknown. We therefore conducted a retrospective study of centenarians with PFFs both to assess: 1) assess clinical outcomes according to geriatric and trauma scores, 2) and to determine whether routine surgery is warranted. HYPOTHESIS: Morbidity and mortality in a single-centre cohort of centenarians with surgically treated PFFs are consistent with previous reports...
December 2, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27919767/internal-fixation-of-intra-capsular-proximal-femoral-fractures-in-patients-older-than-80-years-still-relevant-multivariate-analysis-of-a-prospective-multicentre-cohort
#2
Nicolas Reina, Paul Bonnevialle, Brice Rubens Duval, Philippe Adam, François Loubignac, Thierry Favier, Philippe Massin
BACKGROUND: Arthroplasty is now widely used to treat intra-capsular proximal femoral fractures (PFFs) in older patients, even when there is little or no displacement. However, whether arthroplasty is associated with lower mortality and complication rates in non-displaced or mildly displaced PFFs is unknown. The objectives of this prospective study were: 1) to evaluate early mortality rates with the two treatment methods, 2) to identify risk factors for complications, 3) and to identify predictors of functional decline...
December 2, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27914495/quantitative-increase-in-frailty-is-associated-with-diminished-survival-after-transcatheter-aortic-valve-replacement
#3
Dhaval Chauhan, Nicky Haik, Aurelie Merlo, Bruce J Haik, Chunguang Chen, Marc Cohen, Anne Mosenthal, Mark Russo
BACKGROUND: The purpose of this study is to assess the impact of frailty index comprised of commonly used frailty metrics on outcomes following transcatheter aortic valve replacement (TAVR) outcomes, including mortality, length of stay, and discharge destination. METHODS AND RESULTS: Retrospective data collection was performed for 342 consecutive patients who underwent TAVR at a single center from May 15, 2012, to September 17, 2015. Frailty index score was calculated using 15-ft walk test, Katz activities of daily living, preoperative serum albumin, and dominant handgrip strength...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27913863/-multifocal-intraocular-lens-miol-surgery-in-young-non-presbyopic-ametropes-reasonable-and-safe
#4
A Frings, J Steinberg, S J Linke, V Druchkiv, T Katz
BACKGROUND: Refractive lens exchange and implantation of a multifocal intraocular lens (MIOL) is mainly advised for ametropes with presbyopia. Non-presbyopic young ametropes who wish spectacle-independence are usually treated with corneal refractive surgery or phakic lenses. OBJECTIVES: This retrospective case series aimed to analyse the refractive and subjective satisfaction outcome after MIOL surgery in both eyes of non-presbyopic ametropes where other treatment options were not possible...
December 2, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27902568/health-utilities-in-people-with-chronic-pain-using-a-population-level-survey-and-linked-healthcare-administrative-data
#5
Mary-Ellen Hogan BScPhm, Anna Taddio BScPhm, Joel Katz, Vibhuti Shah, Murray Krahn
Health utilities are a preference-based measure of health-related quality of life that facilitates comparison of disease burden across conditions. We estimated utilities using a population-based, matched sample of adolescents and adults with and without chronic pain, controlling for comorbidity.Ontarians aged ≥12 years with and without chronic pain were identified from the Canadian Community Health Survey (CCHS) 2000-01 and 2009-10 and linked to their provincial healthcare administrative data. Individuals with chronic pain were matched to those without using age, sex, survey year, and a propensity score for having chronic pain estimated from a rurality index, income quintile and comorbidity...
November 24, 2016: Pain
https://www.readbyqxmd.com/read/27896146/determination-of-functional-prognosis-in-hospitalized-patients-following-an-intensive-care-admission
#6
Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, George Ntoumenopoulos, Jerffesson Dias, Fernando S Guimaraes
AIM: To investigate the factors associated with the functional progress of hospitalized patients following an intensive care admission. METHODS: Retrospective study including data from a cohort of 198 hospitalized patients following an intensive care admission and not requiring mechanical ventilation in a single tertiary referral hospital. A generalized linear model was used to identify the main effects of clinical and demographic variables on the outcomes of functionality (KATZ Index of Independence in Activities of Daily Living) and muscle strength (MRC Scale)...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27855633/care-recipients-physical-frailty-is-independently-associated-with-subjective-burden-in-informal-caregivers-in-the-community-setting-a-cross-sectional-study
#7
Thom J Ringer, Afeez Abiola Hazzan, Courtney C Kennedy, Sarah Karampatos, Christopher Patterson, Sharon Marr, Brian Misiaszek, Tricia Woo, George Ioannidis, Alexandra Papaioannou
BACKGROUND: Physical frailty is associated with significant morbidity and mortality in community-dwelling older adults. Burden in informal caregivers of older adults causes significant physical and psychological distress. However, the relationship between these two clinical phenomena has not been extensively studied. This cross-sectional study evaluated the relationship between physical frailty of community-dwelling older adults attending an outpatient geriatric clinic and the subjective burden reported by their informal caregivers...
November 17, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27852905/predictors-and-outcomes-of-crossover-to-surgery-from-physical-therapy-for-meniscal-tear-and-osteoarthritis-a-randomized-trial-comparing-physical-therapy-and-surgery
#8
Jeffrey N Katz, John Wright, Kurt P Spindler, Lisa A Mandl, Clare E Safran-Norton, Emily K Reinke, Bruce A Levy, Rick W Wright, Morgan H Jones, Scott D Martin, Robert G Marx, Elena Losina
BACKGROUND: Arthroscopic partial meniscectomy (APM) combined with physical therapy (PT) have yielded pain relief similar to that provided by PT alone in randomized trials of subjects with a degenerative meniscal tear. However, many patients randomized to PT received APM before assessment of the primary outcome. We sought to identify factors associated with crossing over to APM and to compare pain relief between patients who had crossed over to APM and those who had been randomized to APM...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27849279/oral-health-status-and-functional-capacity-in-the-elderly-a-longitudinal-population-based-study
#9
Yan Nogueira Freitas, Kenio Costa Lima, Diviane Alves da Silva
Introduction: The study of oral health conditions and functional dependency in elderly people represents an important step toward the comprehension of the intervenient factors in the health care of this population. Purpose: This methodological note described strategies and methods adopted in a longitudinal study which has been analyzing the association of oral health conditions with functional dependence among the elderly population in a city located in the countryside of Northeastern Brazil...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/27843557/inclusion-of-walnut-in-the-diets-of-adults-at-risk-for-type-2-diabetes-and-their-dietary-pattern-changes-a-randomized-controlled-cross-over-trial
#10
Valentine Yanchou Njike, Niloufarsadat Yarandi, Paul Petraro, Rockiy G Ayettey, Judith A Treu, David L Katz
BACKGROUND: In our recently published study, including walnuts in the diets of adults with prediabetes led to overall improvement in diet quality. This report adds to those study findings by examining the food groups displaced during walnut inclusion in the diets of those adults with prediabetes. METHODS: Randomized, controlled, modified Latin square parallel design with 2 treatment arms. The 112 participants (31 men, 81 women) were randomly assigned to a diet with or without dietary counseling to regulate calorie intake in a 1:1 ratio...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27832771/semi-quantitative-mri-biomarkers-of-knee-osteoarthritis-progression-in-the-fnih-biomarkers-consortium-cohort%C3%A2-%C3%A2-methodologic-aspects-and-definition-of-change
#11
Frank W Roemer, Ali Guermazi, Jamie E Collins, Elena Losina, Michael C Nevitt, John A Lynch, Jeffrey N Katz, C Kent Kwoh, Virginia B Kraus, David J Hunter
BACKGROUND: To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study. METHODS: We conducted a nested case-control study...
November 10, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27821194/community-and-healthcare-associated-methicillin-resistant-staphylococcus-aureus-strains-an-investigation-into-household-transmission-risk-factors-and-environmental-contamination
#12
Wil Ng, Amna Faheem, Allison McGeer, Andrew E Simor, Antonella Gelosia, Barbara M Willey, Christine Watt, David C Richardson, Henry Wong, Krystyna Ostrowska, Lee Vernich, Matthew P Muller, Piraveina Gnanasuntharam, Vanessa Porter, Kevin Katz
OBJECTIVE To measure transmission frequencies and risk factors for household acquisition of community-associated and healthcare-associated (HA-) methicillin-resistant Staphylococcus aureus (MRSA). DESIGN Prospective cohort study from October 4, 2008, through December 3, 2012. SETTING Seven acute care hospitals in or near Toronto, Canada. PARTICIPANTS Total of 99 MRSA-colonized or MRSA-infected case patients and 183 household contacts. METHODS Baseline interviews were conducted, and surveillance cultures were collected monthly for 3 months from household members, pets, and 8 prespecified high-use environmental locations...
November 8, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27803967/active-surveillance-for-incidental-renal-mass-in-the-octogenarian
#13
Kenan E Celtik, Paras H Shah, Vinay R Patel, Daniel M Moreira, Arvin K George, Valerio Iacovelli, Manaf Alom, Andrew Ng, Amin Herati, Simpa S Salami, Hannah Bierwiler, Michael J Schwartz, Lee Richstone, Joph Steckel, Manish A Vira, Louis R Kavoussi
OBJECTIVE: To evaluate the oncologic outcomes among a large cohort of octogenarian patients placed on active surveillance for a localized renal mass. METHODS: We retrospectively reviewed patients ≥80 years of age presenting for asymptomatic, incidentally detected clinically localized stage T1 renal mass between 2006 and 2013 who were followed by active surveillance (AS). The primary endpoint was development of metastatic renal cell carcinoma. Secondary outcomes included intervention-free survival, cancer-specific survival, and overall survival...
November 1, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27790963/comparison-between-merthiolate-iodine-formalin-and-kato-katz-methods-for-the-diagnosis-of-human-helminth-infections-in-resource-limited-settings
#14
R N Incani, T Homan, E Pinelli, L Mughini-Gras, H Guevara, J Jesus
Diagnosis of intestinal parasites through examination of fresh faecal samples is hampered by its unpleasantness and the urgent need to detect all parasitic forms. In this paper, we compared the standard Kato-Katz (KK) technique with a traditional fixation method, the merthiolate-iodine-formalin (MIF) method. Two hundred and twenty-seven faecal samples from individuals living in a rural setting in Venezuela with high to moderate prevalences of Ascaris lumbricoides (Al), Trichuris trichiura (Tt) and hookworm infections were examined...
October 28, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27790736/body-mass-index-greater-than-35-is-associated-with-severe-clostridium-difficile-infection
#15
R Mulki, A J Baumann, T Alnabelsi, N Sandhu, Y Alhamshari, D S Wheeler, S Perloff, P O Katz
BACKGROUND: Obesity has been implicated in the acquisition of Clostridium difficile infections (CDI), however, no study has investigated whether there is a correlation between body mass index (BMI) and CDI severity. AIM: To determine whether obesity, as measured by BMI correlates with severe hospital-onset or community-onset CDI. METHODS: Patients admitted with CDI at a tertiary-care center from January 2013 to June 2015 were identified. The cohort was stratified by onset of disease using the National Healthcare Safety Network criteria, and by severity using the 2013 American College of Gastroenterology guidelines...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27790048/quality-measure-attainment-with-dapagliflozin-plus-metformin-extended-release-as-initial-combination-therapy-in-patients-with-type-2-diabetes-a-post-hoc-pooled-analysis-of-two-clinical-studies
#16
Kelly F Bell, Arie Katz, John J Sheehan
BACKGROUND: The use of quality measures attempts to improve safety and health outcomes and to reduce costs. In two Phase III trials in treatment-naive patients with type 2 diabetes, dapagliflozin 5 or 10 mg/d as initial combination therapy with metformin extended-release (XR) significantly reduced glycated hemoglobin (A1C) from baseline to 24 weeks and allowed higher proportions of patients to achieve A1C <7% vs dapagliflozin or metformin monotherapy. OBJECTIVE: A pooled analysis of data from these two studies assessed the effect of dapagliflozin 5 or 10 mg/d plus metformin XR (combination therapy) compared with placebo plus metformin XR (metformin monotherapy) on diabetes quality measures...
2016: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/27787891/a-brief-dietary-assessment-predicts-executive-dysfunction-in-an-elderly-cohort-results-from-the-einstein-aging-study
#17
Erin E Sundermann, Mindy J Katz, Richard B Lipton, Alice H Lichtenstein, Carol A Derby
OBJECTIVES: To examine the association between diet and executive function, episodic memory and global verbal cognition in the Einstein Aging Study (EAS) cohort and determine whether race modifies this relationship. DESIGN: Cross-sectional. SETTING: Community. PARTICIPANTS: EAS participants without dementia who completed the Rapid Eating and Activity Assessment for Patients (REAP) (N = 492). MEASUREMENTS: The previously validated REAP is based on the 2000 U...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27748055/long-term-safety-and-efficacy-of-fulranumab-in-patients-with-moderate-to-severe-osteoarthritis-pain-a-randomized-double-blind-placebo-controlled-study
#18
Panna Sanga, Nathaniel Katz, Elena Polverejan, Steven Wang, Kathleen M Kelly, Juergen Haeussler, John Thipphawong
OBJECTIVE: To evaluate long-term safety and efficacy of fulranumab in patients with moderate-to-severe chronic osteoarthritis (OA) knee or hip pain. METHODS: In this placebo-controlled, phase-2 double-blind (DB) extension study, patients who were equally randomized to 1mgQ4wk, 3mgQ8wk, 3mgQ4wk, 6mgQ8wk, or10mgQ8wk fulranumab (s.c.) or placebo in the 12-week DB efficacy phase, and completed this DB efficacy phase, were eligible to continue the dose throughout a 92-week extension phase followed by a 24-week posttreatment follow-up (PFTU)...
October 16, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27746085/the-incidence-risk-factors-and-outcomes-associated-with-late-right-sided-heart-failure-in-patients-supported-with-an-axial-flow-left-ventricular-assist-device
#19
Jonathan D Rich, Igor Gosev, Chetan B Patel, Susan Joseph, Jason N Katz, Peter M Eckman, Sangjin Lee, Kartik Sundareswaran, Ahmet Kilic, Brian Bethea, Behzad Soleimani, Brian Lima, Nir Uriel, Michael Kiernan
BACKGROUND: Early right-sided heart failure (RHF) after left ventricular assist device (LVAD) implantation is associated with increased mortality, but little is known about patients who develop late RHF (LRHF). We evaluated the incidence, risk factors, and clinical impact of LRHF in patients supported by axial-flow LVADs. METHODS: Data were analyzed from 537 patients enrolled in the HeartMate II (HM II; Thoratec/St. Jude) destination therapy clinical trial. LRHF was defined as the development of clinical RHF accompanied by the need for inotropic support occurring more than 30 days after discharge from the index LVAD implant hospitalization...
August 20, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27720414/rotator-cuff-surgery-in-patients-older-than-75-years-with-large-and-massive-tears
#20
Hong Jun Jung, Gyeong-Bo Sim, Kun Hyung Bae, Aashay L Kekatpure, Jae-Myeung Chun, In-Ho Jeon
BACKGROUND: The purpose of this study was to evaluate whether rotator cuff repair improves subjective and functional outcomes in patients aged ≥75 years. METHODS: From May 2005 to March 2013, 121 elderly patients who underwent rotator cuff repair for large and massive rotator cuff tears were evaluated retrospectively. Patients with an American Society of Anesthesiologists physical status classification system grade ≥4 were excluded. The patients were evaluated using visual analog scales, subjective satisfaction surveys, American Shoulder and Elbow Surgeons scores, and Constant scores...
October 5, 2016: Journal of Shoulder and Elbow Surgery
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