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https://www.readbyqxmd.com/read/29141182/optogenetic-activation-of-5-ht-neurons-in-the-dorsal-raphe-suppresses-seizure-induced-respiratory-arrest-and-produces-anticonvulsant-effect-in-the-dba-1-mouse-sudep-model
#1
Honghai Zhang, Haiting Zhao, Chang Zeng, Christa Van Dort, Carl L Faingold, Norman E Taylor, Ken Solt, Hua-Jun Feng
Sudden unexpected death in epilepsy (SUDEP) is a devastating epilepsy complication. Seizure-induced respiratory arrest (S-IRA) occurs in many witnessed SUDEP patients and animal models as an initiating event leading to death. Thus, understanding the mechanisms underlying S-IRA will advance the development of preventive strategies against SUDEP. Serotonin (5-HT) is an important modulator for many vital functions, including respiration and arousal, and a deficiency of 5-HT signaling is strongly implicated in S-IRA in animal models, including the DBA/1 mouse...
November 12, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29140427/sudden-unexpected-cardiac-death-on-monday-in-younger-and-older-men-the-manitoba-follow-up-study
#2
Robert B Tate, Philip D St John
No abstract text is available yet for this article.
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29132773/-maternal-deaths-due-to-sudden-death-results-from-the-french-confidential-enquiry-into-maternal-deaths-2010-2012
#3
E Morau, E Beaumont, E Verspyck
Sudden death is defined as unexpected cardiac arrest occurring less than one hour after the onset of the first symptoms. Between 2010 and 2012, 23 maternal deaths were considered as unexplained sudden deaths and three of them were not evaluated due to a lack of clinical data. In addition, 13 maternal deaths with an identified cause occurred in a clinical context of sudden death (7 cases of pulmonary embolism, 2 cases of epilepsy, and 2 cases of cardiomyopathy). The first maneuvers of resuscitation in the presence of bystanders were attempted in 8 of 22 cases (36%)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29128679/early-onset-epileptic-encephalopathy-with-de-novo-scn8a-mutation
#4
Yangyang Xiao, Jie Xiong, Ding'an Mao, Lingjuan Liu, Jian Li, Xingfang Li, Haiyan Luo, Liqun Liu
Early-onset epileptic encephalopathies (EOEEs) are clinically and genetically heterogeneous disorders characterized by intractable seizures and unremitting interictal paroxysmal epileptiform activity. Consequently, these syndromes impair neurodevelopment during the first year of life. Currently, the etiology of these disorders is largely unknown. In this study, Childhood-Onset Epilepsy Gene Panel Testing (containing 511 epilepsy-related genes) was performed in a parent-offspring trio. In this family, the son had refractory seizures, intellectual disability, and motor abnormalities, and he was diagnosed with EOEE...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29125216/evaluation-of-a-sudden-unexpected-death-in-infancy-intervention-programme-aimed-at-improving-parental-awareness-of-risk-factors-and-protective-infant-care-practices
#5
Christine McIntosh, Adrian Trenholme, Joanna Stewart, Alison Vogel
AIM: Sudden unexpected death in infancy (SUDI) rates for Māori and Pacific infants remain higher than for other ethnic groups in New Zealand and bed-sharing is a major risk factor when there is smoking exposure in pregnancy. Sleep space programmes of education and Pēpi-Pod baby beds require evaluation. METHODS: Two hundred and forty Māori and Pacific women and infants were randomised 1:1, to the Pēpi-Pod sleep space programme, or to a control group with 'usual care'...
November 10, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29105057/potentially-high-risk-cardiac-arrhythmias-with-focal-to-bilateral-tonic-clonic-seizures-and-generalized-tonic-clonic-seizures-are-associated-with-the-duration-of-periictal-hypoxemia
#6
Katherine J Park, Gaurav Sharma, Jeffrey D Kennedy, Masud Seyal
OBJECTIVE: To investigate potentially high-risk cardiac arrhythmias (PHAs) following focal to bilateral tonic-clonic seizures (FBTCSs) and generalized tonic-clonic seizures (GTCSs) and to study the association of PHAs with seizure characteristics and the severity of associated ictal respiratory dysfunction. METHODS: Electrocardiographic (EKG) and pulse oximetry (SpO2 ) data were recorded concurrently with video-electroencephalographic telemetry in the epilepsy monitoring unit (EMU)...
November 3, 2017: Epilepsia
https://www.readbyqxmd.com/read/29090925/quantitative-proteomic-analysis-to-identify-differentially-expressed-proteins-in-the-myocardium-of-epilepsy-using-itraq-coupled-with-nano-lc-ms-ms
#7
Peng Zhang, Li Zhang, Yongguo Li, Shisheng Zhu, Minzhu Zhao, Shijia Ding, Jianbo Li
Epilepsy is a difficult-to-manage neurological disease that can result in organ damage, such as cardiac injury, that contributes to sudden unexpected death in epilepsy (SUDEP). Although recurrent seizure-induced cardiac dysregulation has been reported, the underlying molecular mechanisms are unclear. We established an epileptic model with Sprague-Dawley rats, applying isobaric tags for a relative and absolute quantification (iTRAQ)-based proteomics approach to identify differentially expressed proteins in myocardial tissue...
November 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29071466/cardiovascular-autonomic-effects-of-vagus-nerve-stimulation
#8
REVIEW
Iñigo Garamendi-Ruiz, Juan Carlos Gómez-Esteban
The vagus nerve is responsible for the parasympathetic innervation of the major thoracic and abdominal organs. It also carries sensory afferent fibres from these viscera and reaches different brain structures. These connections have proven useful in the treatment of different diseases. Afferent stimulation of the left vagus nerve is used to treat epilepsy and major depression, and stimulation of the right vagus nerve is being tried for the treatment of heart failure. The device used for the therapy delivers intermittent stimuli...
October 25, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29067975/sudden-unexpected-death-in-epilepsy
#9
REVIEW
Shishir Nagesh Duble, Sanjeev V Thomas
People with epilepsy have increased risk of premature death, and their life expectancy may reduce by 2-10 yr. Population- and hospital-based studies have shown that the excess mortality in epilepsy is not entirely explained by deaths directly attributable to epilepsy such as accidents and drowning during a seizure. It is also significantly contributed by deaths from other causes such as cardiac deaths, deaths due to malignancies and other causes. It had recently been recognized that sudden unexpected deaths in epilepsy (SUDEP) contributed to a small yet important proportion of mortality in epilepsy...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29060913/detection-of-generalized-tonic-clonic-seizures-using-short-length-accelerometry-signal
#10
Shitanshu Kusmakar, Chandan K Karmakar, Bernard Yan, Terence J O'Brien, Ramanathan Muthuganapathy, Marimuthu Palaniswami
Epileptic seizures are characterized by the excessive and abrupt electrical discharge in the brain. This asynchronous firing of neurons causes unprovoked convulsions which can be a cause of sudden unexpected death in epilepsy (SUDEP). Remote monitoring of epileptic patients can help prevent SUDEP. Systems based on wearable accelerometer sensors have shown to be effective in ambulatory monitoring of epileptic patients. However, these systems have a trade-off between seizure duration and the false alarm rate (FAR)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29049067/sudden-unexpected-postnatal-collapse-and-sudden-unexpected-infant-death
#11
Kathleen Rice Simpson
No abstract text is available yet for this article.
November 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29033634/sudden-unexpected-death-in-epilepsy-a-retrospective-autopsy-study-of-112-epileptic-patients
#12
İpek Esen Melez, Murat Nihat Arslan, Deniz Oğuzhan Melez, Ahmet Necati Şanli, Sermet Koç
INTRODUCTION: Sudden unexpected deaths comprise the most important and worthy investigation case profiles in both neurology and forensic medicine. Epilepsy, which is one of the neuropathological causes of sudden unexpected deaths, is an important disorder having mysterious aspects. The aim of this study is to make common the points of view between neurology and forensic medicine experts and to discuss the features of the findings together with the related clinical hypotheses, leading to the differential diagnosis of sudden unexpected death in epilepsy (SUDEP) by presenting autopsy findings and available medical data of patients who had a prior diagnosis of epilepsy...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28984706/engaging-community-health-workers-in-the-effort-to-prevent-sudden-unexpected-death-and-death-from-chronic-illness
#13
Shivani Sud, Irion Pursell, Golsa Joodi, Ross J Simpson
No abstract text is available yet for this article.
December 2017: Medical Care
https://www.readbyqxmd.com/read/28984117/sudden-unexpected-postnatal-collapse-at-20-hours-from-birth-during-skin-to-skin-care-related-to-brainstem-developmental-alterations-a-case-report
#14
Anna M Lavezzi, Francesco Piscioli, Teresa Pusiol
This report describes a case of sudden collapse of a 20-hour-old newborn, while he was placed close to their mother according to skin-to-skin care, attributed to developmental alterations of brainstem nuclei involved in regulation of the vital functions. The infant, after a normal pregnancy, appeared well developed at birth, with no evidence of malformations or trauma, but showing severe asphyxia. The routine autopsy did not reveal a possible cause of death. Only the in-depth anatomopathological examination of the autonomic nervous system, according to the protocol developed by the "Lino Rossi" Research Center of Milan University, provided an explanation of the pathogenetic mechanism of this early death...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28983274/ranking-the-leading-risk-factors-for-sudden-unexpected-death-in-epilepsy
#15
REVIEW
Christopher M DeGiorgio, Daniela Markovic, Rajarshi Mazumder, Brian D Moseley
BACKGROUND: Sudden unexpected death in epilepsy (SUDEP) is rare in well-controlled epilepsy. However, SUDEP is a common cause of death in drug-resistant epilepsy. Over the last 30 years, multiple cohort and population studies have identified clinical risk factors associated with an increased risk for SUDEP. OBJECTIVE: To identify and rank the leading SUDEP risk factors from major cohort and population-based studies. The incidence of SUDEP is also evaluated in special clinical situations, including antiepileptic drug treatment, epilepsy surgery, devices, and assignment to placebo in clinical trials...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28982711/sudden-death-after-febrile-seizure-case-report-cerebral-suppression-precedes-severe-bradycardia
#16
Kenneth A Myers, Robyn E McPherson, Robin Clegg, Jeffrey Buchhalter
A 20-month-old girl with a complex chromosomal disorder had first presentation of febrile status epilepticus and was admitted to the hospital. Two days after her initial seizure, she died suddenly and unexpectedly during a video EEG monitoring study. An advanced analysis of the physiologic changes in the hours and minutes leading up to death was undertaken. The electrocardiography over the last 19 minutes of life was reviewed, and the R-R intervals were manually measured. Heart rate variability was assessed through calculation of the SD of the R-R intervals and the root mean square of successive differences over successive 100 beat periods...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/28980315/multicenter-clinical-assessment-of-improved-wearable-multimodal-convulsive-seizure-detectors
#17
MULTICENTER STUDY
Francesco Onorati, Giulia Regalia, Chiara Caborni, Matteo Migliorini, Daniel Bender, Ming-Zher Poh, Cherise Frazier, Eliana Kovitch Thropp, Elizabeth D Mynatt, Jonathan Bidwell, Roberto Mai, W Curt LaFrance, Andrew S Blum, Daniel Friedman, Tobias Loddenkemper, Fatemeh Mohammadpour-Touserkani, Claus Reinsberger, Simone Tognetti, Rosalind W Picard
OBJECTIVE: New devices are needed for monitoring seizures, especially those associated with sudden unexpected death in epilepsy (SUDEP). They must be unobtrusive and automated, and provide false alarm rates (FARs) bearable in everyday life. This study quantifies the performance of new multimodal wrist-worn convulsive seizure detectors. METHODS: Hand-annotated video-electroencephalographic seizure events were collected from 69 patients at six clinical sites. Three different wristbands were used to record electrodermal activity (EDA) and accelerometer (ACM) signals, obtaining 5,928 h of data, including 55 convulsive epileptic seizures (six focal tonic-clonic seizures and 49 focal to bilateral tonic-clonic seizures) from 22 patients...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/28975231/death-and-cardiac-arrest-in-u-s-triathlon-participants-1985-to-2016-a-case-series
#18
Kevin M Harris, Lawrence L Creswell, Tammy S Haas, Taylor Thomas, Monica Tung, Erin Isaacson, Ross F Garberich, Barry J Maron
Background: Reports of race-related triathlon fatalities have raised questions regarding athlete safety. Objective: To describe death and cardiac arrest among triathlon participants. Design: Case series. Setting: United States. Participants: Participants in U.S. triathlon races from 1985 to 2016. Measurements: Data on deaths and cardiac arrests were assembled from such sources as the U...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28972036/sudep-the-aftermath-supporting-the-bereaved
#19
Lina Nashef, John Paul Leach
Sudden unexpected death in epilepsy is a recurring calamity, yet there is little evidence to guide standards of care for supporting the bereaved. Grief in bereavement includes loss, feelings of guilt, anger and blame. There is also the shock and trauma of the sudden event. How can this be alleviated? This paper focuses on guiding the physician to support the bereaved, while recognising the limited evidence and the varying circumstances that may not always facilitate this. We propose a pathway of care and mode of communication with the deceased's family, with whom contact is currently limited...
September 28, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28967460/ictal-symmetric-tonic-extension-posturing-and-postictal-generalized-eeg-suppression-arising-from-sleep-in-children-with-epilepsy
#20
Kazuo Okanari, Hiroshi Otsubo, Elizabeth Kouzmitcheva, Jagadish Rangrej, Shiro Baba, Ayako Ochi, Tohru Okanishi, Yoichiro Homma, Dragos A Nita, Elizabeth J Donner
BACKGROUND: The identification of a biomarker for sudden unexpected death in epilepsy (SUDEP) has the potential to save lives. Generalized convulsive seizures and postictal generalized suppression on electroencephalography (EEG) most often precede sudden unexpected death in epilepsy (SUDEP) and are potential biomarkers. We identify the EEG and seizure characteristics associated with postictal generalized EEG suppression in children with epilepsy. METHODS: Video EEGs were reviewed for seizure type, duration and semiology, and electrographic features...
July 4, 2017: Pediatric Neurology
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