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Tendon Repair

N de Cesare, C Trevisan, E Maghin, M Piccoli, P G Pavan
The diaphragm is a mammalian skeletal muscle that plays a fundamental role in the process of respiration. Alteration of its mechanical properties due to a diaphragmatic hernia contributes towards compromising its respiratory functions, leading to the need for surgical intervention to restore the physiological conditions by means of implants. This study aims to assess via numerical modeling biomechanical differences between a diaphragm in healthy conditions and a herniated diaphragm surgically repaired with a polymeric implant, in a mouse model...
June 15, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Michael D Kurdziel, Abigail Davidson, David Ross, Joseph Seta, Shashin Doshi, Kevin C Baker, Tristan Maerz
PURPOSE: The rat rotator cuff (RC) model is used to study RC pathology and potential treatment, however, native scar-mediated healing allows the rat RC to recover at 4-6 weeks but little is known about acute healing. This study characterized the properties of the repaired and non-repaired rat RC following surgical detachment. MATERIALS AND METHODS: Forty-eight rats underwent surgical RC detachment and received surgical repair (Repair) or left unrepaired (Defect)to either 12 or 19 days...
June 22, 2018: Connective Tissue Research
Kairui Zhang, Michael W Hast, Soutarou Izumi, Yu Usami, Snehal Shetye, Ngozi Akabudike, Nancy J Philp, Masahiro Iwamoto, Itzhak Nissim, Louis J Soslowsky, Motomi Enomoto-Iwamoto
BACKGROUND: Tendon injuries are common problems among athletes. Complete recovery of the mechanical structure and function of ruptured tendons is challenging. It has been demonstrated that upregulation of glycolysis and lactate production occurs in wounds, inflammation sites, and cancerous tumors, and these metabolic changes also control growth and differentiation of stem and progenitor cells. Similar metabolic changes have been reported in human healing tendons. In addition, lactate production has increased in progenitors isolated from injured tendons after treatment with IL-1β...
June 1, 2018: American Journal of Sports Medicine
Michael J Mienaltowski, Angela Cánovas, Valerie A Fates, Angela R Hampton, Monica Y Pechanec, Alma Islas-Trejo, Juan F Medrano
Progenitor cells of the tendon proper and peritenon have unique properties that could impact their utilization in tendon repair strategies. While a few markers have been found to aid in distinguishing progenitors cells from each region, there is great value in identifying more markers. In this study, we hypothesized that RNAseq could be used to improve our understanding of those markers that define these cell types. Transcriptome profiles were generated for pools of mouse Achilles tendon progenitor cells from both regions and catalogues of potential markers were generated...
June 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Geoffrey C S Smith, Patrick H Lam
PURPOSE: The self-reinforcement mechanism after double row suturebridge rotator cuff repair generates increasing compressive forces at the tendon footprint with increasing tendon load. Passive range of motion is usually allowed after rotator cuff repair. The mechanism of self-reinforcement could be adversely affected by shoulder abduction. METHODS: Rotator cuff tears were created ex vivo in nine pairs of ovine shoulders. Two different repair techniques were used...
June 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Jeremy Truntzer, Kevin Mertz, Sara Eppler, Kevin Li, Michael Gardner, Robin Kamal
BACKGROUND: In distal radius fracture repair, complications often lead to reoperation and increased cost. We examined the trends and complications in open reduction internal fixation of distal radius fractures across hand specialist and non-hand specialist surgeons. METHODS: We examined claims data from the Humana administrative claims database between 2007 and 2016. International Classification of Disease, 9th Edition and Current Procedural Terminology codes were searched related to distal radius fractures repaired by open reduction internal fixation...
June 19, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Ali Güleç, Yılmaz Türk, Bahattin Kerem Aydin, Ömer Faruk Erkoçak, Selim Safalı, Ceyhan Ugurluoglu
PURPOSE: This in vivo study aims to investigate the effects of curcumin which is recently developed for tendon healing using a rat Achilles tendon injury model. MATERIALS AND METHODS: Eighteen male Wistar albino rats weighing 300-400 g were used in this study. Under anesthesia, Achilles tendon injuries were created and repaired surgically. Nine rats of the study group received curcumin (suspended in saline at a dose of 200 mg/kg orally) and eight rats of the control group received only saline solution by oral gavage for a period of 28 days...
June 19, 2018: International Orthopaedics
D González-Quevedo, I Martínez-Medina, A Campos, F Campos, V Carriel
Objectives: Recently, the field of tissue engineering has made numerous advances towards achieving artificial tendon substitutes with excellent mechanical and histological properties, and has had some promising experimental results. The purpose of this systematic review is to assess the efficacy of tissue engineering in the treatment of tendon injuries. Methods: We searched MEDLINE, Embase, and the Cochrane Library for the time period 1999 to 2016 for trials investigating tissue engineering used to improve tendon healing in animal models...
April 2018: Bone & Joint Research
Mohammad R Khan, Jayesh Dudhia, Frederic H David, Roberta De Godoy, Vedika Mehra, Gillian Hughes, Stephanie G Dakin, Andrew J Carr, Allen E Goodship, Roger K W Smith
BACKGROUND: Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem cells (MSCs) although the effects of the intra-synovial environment on the distribution, engraftment and functionality of implanted MSCs is not known. This study utilised a novel sheep model which, although in an anatomically different location, more accurately mimics the mechanical and synovial environment of the human rotator cuff, to determine the effects of intra-synovial implantation of MSCs...
June 19, 2018: Stem Cell Research & Therapy
Masato Ohara, Ryo Oda, Shogo Toyama, Yusei Katsuyama, Hiroyoshi Fujiwara, Toshikazu Kubo
INTRODUCTION: Closed flexor tendon rupture after a malunited distal radius fracture is rare and usually becomes apparent early after the fracture. Most cases are accompanied by a severe distal radio-ulnar joint capsule injury, wherein bone protrusion (as a spur) directly stresses the tendons. We experienced a nonspecific flexor tendon rupture associated with an old fracture and the presence of collagen disease. PRESENTATION OF CASE: A 63-year-old woman presented with delayed complete rupture of the flexor digitorum profundus (FDP) of the fifth digit...
May 29, 2018: International Journal of Surgery Case Reports
Brian P Gladnick, John L Masonis
Release of the conjoined tendon has been reported to facilitate femoral exposure during a direct anterior hip approach. However, the authors are not familiar with any description of an anterior approach repair technique for this important structure. Conjoined tendon repair is commonly performed in the posterior approach to help preserve hip biomechanics and restore anatomic tissue planes. The authors describe their algorithm for sequential soft tissue releases to facilitate femoral exposure and a technique for repairing the insertion of the conjoined tendon after it has been released for exposure during the direct anterior approach...
June 18, 2018: Orthopedics
Deepak N Bhatia, Vikram Kandhari
BACKGROUND: This cadaveric study was designed to analyze the safety of endoscopic repair of distal biceps tendon (DBT) tears using 2 reattachment techniques. We evaluated the proximity of neurovascular structures to endoscopy portals; iatrogenic injury to neurovascular, musculotendinous, and osseous structures; and changes in compartment pressures. We hypothesized that an all-endoscopic repair of the ruptured DBT would be technically safe and the risk of iatrogenic injury would be low...
June 12, 2018: Journal of Shoulder and Elbow Surgery
Piyush Mahapatra, Saman Horriat, Bobby S Anand
BACKGROUND: This article provides a detailed narrative review on the history and current concepts surrounding ligamentous repair techniques in athletic patients. In particular, we will focus on the anterior cruciate ligament (ACL) as a case study in ligament injury and ligamentous repair techniques. PubMed (MEDLINE), EMBASE and Cochrane Library databases for papers relating to primary anterior cruciate ligament reconstruction were searched by all participating authors. All relevant historical papers were included for analysis...
June 15, 2018: Journal of Experimental Orthopaedics
Rebecca Bell, N Remi Gendron, Matthew Anderson, Evan L Flatow, Nelly Andarawis-Puri
Tendons are ineffective at repairing sub-rupture fatigue injuries. Accordingly, we evaluated whether an exercise protocol that we have previously found to decrease structural damage kinks in fatigue damaged tendons, leads to improvement in mechanical properties. We hypothesized that exercise that promotes repair of fatigue damage will decrease apoptosis and increase the population of myofibroblasts. Rat patellar tendons underwent in vivo fatigue loading for 500 or 7200 cycles. Animals resumed cage activity for 2-weeks, then either remained cage active or began treadmill running until sacrifice at 4- or 10-weeks post-fatigue loading...
June 12, 2018: Scientific Reports
Finosh G Thankam, Zachary K Roesch, Matthew F Dilisio, Mohamed M Radwan, Anuradha Kovilam, R Michael Gross, Devendra K Agrawal
Inflammation and extracellular matrix (ECM) disorganization following the rotator cuff tendon injuries (RCTI) delay the repair and healing process and the molecular mechanisms underlying RCTI pathology are largely unknown. Here, we examined the role of HMGB1 and NLRP3 inflammasome pathway in the inflammation and ECM disorganization in RCTI. This hypothesis was tested in a tenotomy-RCTI rat model by transecting the RC tendon from the humerus. H&E and pentachrome staining revealed significant changes in the morphology, architecture and ECM organization in RC tendon tissues following RCTI when compared with contralateral control...
June 11, 2018: Scientific Reports
Derek T Bernstein, Jamie J Alexander, Nancy J Petersen, Bradley S Lambert, Philip C Noble, David T Netscher
PURPOSE: To evaluate the impact of suture caliber and looped configurations on the integrity of 4-strand modified Kessler zone II flexor tendon repairs during progressive cyclic loading. METHODS: Seventy-two flexor digitorum profundus tendons from 18 fresh human cadaver hands were divided into 4 repair groups. Thirty-six matched tendons underwent repair using either a 4-0 looped or 4-0 single-stranded suture, and an additional 36 tendons underwent 3-0 looped or 3-0 single-stranded repairs...
June 8, 2018: Journal of Hand Surgery
Can Chen, Hongbin Lu, Jianzhong Hu, Xuqiang Qiu, Xiong Li, Deyi Sun, Jin Qu, Tao Zhang, Daqi Xu
INTRODUCTION: Anatomic repair of the anterior talofibular ligament (ATFL) is challenging when the local ligamentous tissue is severely attenuated. Anatomic reconstruction of the ATFL with tibial tuberosity-patellar tendon (TT-PT) autograft is a feasible choice that can avoid the complicated tendon-bone healing and restore ankle stability. MATERIALS AND METHODS: From 2009 to 2015, 31 chronic lateral ankle instability (CLAI) patients (31 ankles), who had a serious injury on the ATFL only, were treated with anatomic reconstruction of ATFL with TT-PT...
May 2018: Journal of Orthopaedic Surgery
Simon J Murphy, David J Rennie
No abstract text is available yet for this article.
June 2018: Current Sports Medicine Reports
Z Tuna, D Oskay
After tendon injuries, it has been observed clinically that patient-reported disability is more severe than the patient's actual performance. This is thought to result from a fear of movement (kinesiophobia) after surgery. The aim of this study was to investigate the presence of kinesiophobia in this patient population and its effects on the clinical outcomes. Patients (n=118) with tendon repairs were included. All the participants received early passive mobilization and were assessed at the end of the 8th week...
June 7, 2018: Hand Surgery and Rehabilitation
Daisuke Momma, Akimoto Nimura, Satoru Muro, Hitomi Fujishiro, Takashi Miyamoto, Tadanao Funakoshi, Tomoyuki Mochizuki, Norimasa Iwasaki, Keiichi Akita
BACKGROUND: Although conventional Bankart repair has been the accepted procedure for traumatic anterior glenohumeral instability, the humeral avulsion of the glenohumeral ligament or an elongation of the capsule remains challenging to decide the appropriate treatment. The anatomical knowledge regarding the whole capsule of glenohumeral joint is necessary to accurately treat for the capsular disorders. The aims of the current study were to investigate the anatomical features of capsular attachment and thickness in a whole capsule of glenohumeral joint...
June 7, 2018: Journal of Experimental Orthopaedics
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