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https://www.readbyqxmd.com/read/29208860/high-wall-motion-score-index-after-acute-myocardial-infarction-is-associated-with-worse-in-hospital-outcome
#1
H Pandit, M N Islam, M A Bari, P Pandit, M S Bari, A S Bhuiyan, R K Talukder, M A Rouf, M S Islam, S S Shakil, M S Islam, H Akhter
Myocardial Infarction is a major cause of death and disability worldwide. The incidence of coronary heart disease is high and second most cause of death after cancer. This prospective study conducted on 100 patients admitted with first attack of acute myocardial infarction in the department of Cardiology in Mymensingh Medical College Hospital, Mymensingh, Bangladesh from July 2012 to June 2013 who were observed 3 to 8 days of hospital stay without doing further echocardiography and evaluated the relationship between echocardiographic wall motion score index (WMSI) assessed within 24 hours of admission and in-hospital outcomes...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29197997/class-effects-of-sglt2-inhibitors-in-mouse-cardiomyocytes-and-hearts-inhibition-of-na-h-exchanger-lowering-of-cytosolic-na-and-vasodilation
#2
Laween Uthman, Antonius Baartscheer, Boris Bleijlevens, Cees A Schumacher, Jan W T Fiolet, Anneke Koeman, Milena Jancev, Markus W Hollmann, Nina C Weber, Ruben Coronel, Coert J Zuurbier
AIMS/HYPOTHESIS: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) constitute a novel class of glucose-lowering (type 2) kidney-targeted agents. We recently reported that the SGLT2i empagliflozin (EMPA) reduced cardiac cytosolic Na+ ([Na+]c) and cytosolic Ca2+ ([Ca2+]c) concentrations through inhibition of Na+/H+ exchanger (NHE). Here, we examine (1) whether the SGLT2i dapagliflozin (DAPA) and canagliflozin (CANA) also inhibit NHE and reduce [Na+]c; (2) a structural model for the interaction of SGLT2i to NHE; (3) to what extent SGLT2i affect the haemodynamic and metabolic performance of isolated hearts of healthy mice...
December 2, 2017: Diabetologia
https://www.readbyqxmd.com/read/29196938/the-hemodynamic-and-pain-impact-of-peripheral-nerve-block-versus-spinal-anesthesia-in-diabetic-patients-undergoing-diabetic-foot-surgery
#3
Hou Yee Lai, Li Lian Foo, Siu Min Lim, Chen Fei Yong, Pui San Loh, Sook Hui Chaw, Mohd Shahnaz Hasan, Chew Yin Wang
PURPOSE: Comparison of hemodynamic profiles and pain scores in diabetic patients undergoing diabetic foot surgery receiving peripheral nerve block (PNB) or spinal anesthesia [subarachnoid block (SAB)]. METHODS: This was a prospective, randomised controlled trial. We recruited diabetic patients aged > 18 years, American Society of Anesthesiologists class II-III, who were scheduled for unilateral diabetic foot surgery below the knee. All patients were assessed for autonomic dysfunction using the Survey of Autonomic Symptoms score...
December 1, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29175281/predicting-survival-in-heart-failure-patients-with-an-implantable-cardioverter-defibrillator-the-heart-failure-meta-score
#4
Ana C Alba, Stephen D Walter, Gordon H Guyatt, Wayne C Levy, Jiming Fang, Heather J Ross, Douglas S Lee
BACKGROUND: Prognostic evaluation in heart failure (HF) is important to predict future events and decide timely management. Many HF patients are treated with an implantable cardioverter defibrillator (ICD). This study aimed to validate a meta-analytically-derived prognostic score to predict survival in ICD-HF patients. METHODS AND RESULTS: The HF Meta-Score includes 14 independent mortality predictors identified in a meta-analysis, including age, sex, ethnicity, diabetes, chronic obstructive pulmonary disease, peripheral vascular disease, atrial fibrillation, ischemic cardiomyopathy, history of heart failure admission, NYHA class, left ventricular ejection fraction, renal function, QRS duration, secondary prevention indication and ICD shocks...
November 22, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29171848/a-pilot-study-on-clinical-pharmacokinetics-and-preclinical-pharmacodynamics-of-epicatechin-on-cardiometabolic-endpoints
#5
Aldo Moreno-Ulloa, Nayelli Nájera-García, Marcela Hernández, Israel Ramírez-Sánchez, Pam R Taub, Yongxuan Su, Ernesto Beltrán-Partida, Guillermo Ceballos, Sundeep Dugar, George Schreiner, Brookie M Best, Theodore P Ciaraldi, Robert R Henry, Francisco Villarreal
We reported that (-)-epicatechin can stimulate mitochondria biogenesis and improve metabolism. However, preliminary studies indicate that the (+) stereoisomer form may be more potent. We evaluated in a preliminary manner, the pharmacokinetics (PK) and initial safety analysis of (+)-epicatechin ((+)-Epi) in healthy and pre-diabetic subjects. Using a mouse model of diet-induced obesity and insulin resistance, we also evaluated the metabolic effects of (+)-Epi vs. (+)-catechin (Cat) to determine class effects...
November 24, 2017: Food & Function
https://www.readbyqxmd.com/read/29153498/hemodynamic-assessment-before-and%C3%A2-after-endovascular-therapy-for-critical%C3%A2-limb-ischemia-and-association-with-clinical-outcomes
#6
Grant W Reed, Laura Young, Imad Bagh, Michael Maier, Mehdi H Shishehbor
OBJECTIVES: This study sought to determine the relationship between change in ankle-brachial index (ABI) and toe-brachial index (TBI) and outcomes following revascularization of critical limb ischemia (CLI). BACKGROUND: An increase in ABI of 0.15 after revascularization for peripheral artery disease with claudication is considered significant. However, the utility of using change in ABI or TBI to predict outcomes in patients with CLI is unproven. METHODS: This was an observational study of 218 patients with Rutherford class V or VI CLI that underwent endovascular therapy...
November 7, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29149618/effectiveness-of-a-patient-centred-empowerment-based-intervention-programme-among-patients-with-poorly-controlled-type-2-diabetes-a-randomised-controlled-trial
#7
Li Cheng, Janet W H Sit, Kai-Chow Choi, Sek-Ying Chair, Xiaomei Li, Yuning Wu, Junhong Long, Meihua Tao
BACKGROUND: Despite extensive efforts and advances in evidence-based diabetes management, poor glycaemic control still remains a challenge in many countries. There is a paucity of research addressing the needs of patients with poorly controlled type 2 diabetes, or exploring the effectiveness of empowerment-based interventions in this vulnerable population. OBJECTIVES: To evaluate the effectiveness of a patient-centred, empowerment-based programme on glycaemic control and self-management behaviours among patients with poorly controlled type 2 diabetes...
November 3, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29136819/alteration-in-the-liver-metabolome-of-rats-with-metabolic-syndrome-after-treatment-with-hydroxytyrosol-a-mass-spectrometry-and-nuclear-magnetic-resonance-based-metabolomics-study
#8
Ioanna Dagla, Dimitra Benaki, Eirini Baira, Nikolaos Lemonakis, Hemant Poudyal, Lindsay Brown, Anthony Tsarbopoulos, Alexios-Leandros Skaltsounis, Emmanouel Mikros, Evagelos Gikas
Metabolic syndrome (MetS) represents a group of abnormalities that enhances the risk for cardiovascular disease, diabetes and stroke. The Mediterranean diet seems to be an important dietary pattern, which reduces the incidence of MetS. Hydroxytyrosol (HT) - a simple phenol found in olive oil - has received increased attention for its antioxidant activity. Recently, the European Foods Safety Authority (EFSA) claimed that dietary consumption of HT exhibits a protective role against cardiovascular disease. In this study, an experimental protocol has been setup, including isolated HT administration in a diet induced model of MetS in young Wistar rats, in order to find out whether HT has a protective effect against MetS...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29103418/hypolipidemic-activity-of-tamarix-articulata-vahl-in-diabetic-rats
#9
Morad Hebi, Mohamed Eddouks
OBJECTIVE: Tamarix articulata Vahl. (Tamaricaceae) is a medicinal plant commonly used in Morocco for the treatment of diabetes mellitus and cardiovascular diseases. The objective of this study was to evaluate the hypolipidemic activity of aqueous extract of T. articulata in normal and streptozotocin (STZ)-induced diabetic rats. Phytochemical analysis as well as determination of polyphenol and flavonoid contents in the aqueous extract of T. articulata was performed. METHODS: The effects of oral administration of aqueous extract of T...
November 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29071110/real-world-weight-change-among-patients-treated-with-glucagon-like-peptide-1-receptor-agonist-dipeptidyl-peptidase-4-inhibitor-and-sulfonylureas-for-type-2-diabetes-and-the-influence-of-medication-adherence
#10
G S Carls, R Tan, J Y Zhu, E Tuttle, J Yee, S V Edelman, W H Polonsky
AIMS: The study aims to examine real-world weight change and the role of medication adherence among patients with type 2 diabetes who initiated one of three drug classes: glucagon-like peptide-1 receptor agonist (GLP-1RA), dipeptidyl peptidase-4 inhibitor (DPP4) and sulfonylureas (SUs). MATERIALS AND METHODS: A cohort of patients initiating one of the three drug classes was selected from a large US database of integrated electronic medical record and administrative claims...
September 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29046921/pioglitazone-reduces-cold-induced-brown-fat-glucose-uptake-despite-induction-of-browning-in-cultured-human-adipocytes-a-randomised-controlled-trial-in-humans
#11
Rebecca K C Loh, Melissa F Formosa, Nina Eikelis, David A Bertovic, Mitchell J Anderson, Shane A Barwood, Shane Nanayakkara, Neale D Cohen, Andre La Gerche, Anne T Reutens, Kenneth S Yap, Thomas W Barber, Gavin W Lambert, Martin H Cherk, Stephen J Duffy, Bronwyn A Kingwell, Andrew L Carey
AIMS/HYPOTHESIS: Increasing brown adipose tissue (BAT) activity is a possible therapeutic strategy to increase energy expenditure and glucose and lipid clearance to ameliorate obesity and associated comorbidities. The thiazolidinedione (TZD) class of glucose-lowering drugs increase BAT browning in preclinical experimental models but whether these actions extend to humans in vivo is unknown. The aim of this study was to determine the effect of pioglitazone treatment on adipocyte browning and adaptive thermogenesis in humans...
October 18, 2017: Diabetologia
https://www.readbyqxmd.com/read/29035554/star-polymers-reduce-iapp-toxicity-via-accelerated-amyloid-aggregation
#12
Emily H Pilkington, May Lai, Xinwei Ge, William J Stanley, Bo Wang, Miaoyi Wang, Aleksandr Kakinen, Marc-Antoine Sani, Michael R Whittaker, Esteban N Gurzov, Feng Ding, John F Quinn, Thomas P Davis, Pu Chun Ke
Protein aggregation into amyloid fibrils is a ubiquitous phenomenon across the spectrum of neurodegenerative disorders and type 2 diabetes. A common strategy against amyloidogenesis is to minimize the populations of toxic oligomers and protofibrils by inhibiting protein aggregation with small molecules or nanoparticles. However, melanin synthesis in nature is realized by accelerated protein fibrillation to circumvent accumulation of toxic intermediates. Accordingly, we designed and demonstrated the use of star-shaped poly(2-hydroxyethyl acrylate) (PHEA) nanostructures for promoting the aggregation while ameliorating the toxicity of human islet amyloid polypeptide (IAPP), the peptide involved in glycemic control and the pathology of type 2 diabetes...
October 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29032638/sodium-glucose-co-transporter-2-inhibitor-tofogliflozin-shows-better-improvements-of-blood-glucose-and-insulin-secretion-in-patients-with-high-insulin-levels-at-baseline
#13
Kazuyuki Tobe, Hideki Suganami, Kohei Kaku
INTRODUCTION: Sodium glucose co-transporter 2 (SGLT2) inhibitors are a new class of drugs for the treatment of type 2 diabetes mellitus that improve control of plasma glucose and body weight, giving great hope for the clinical utility of these agents. However, it is unclear for which patients that SGLT2 inhibitors will be useful. MATERIALS AND METHODS: We analyzed data from long-term tofogliflozin monotherapy in an open-label, randomized controlled trial in Japanese patients with type 2 diabetes mellitus...
October 15, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29031415/usefulness-of-the-crt-score-for-shared-decision-making-in-cardiac-resynchronization-therapy-in-patients-with-a-left-ventricular-ejection-fraction-of-%C3%A2-35
#14
Ulas Höke, Bart Mertens, Mand J H Khidir, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29021336/pooled-analysis-of-multiple-crossover-trials-to-optimize-individual-therapy-response-to-renin-angiotensin-aldosterone-system-intervention
#15
Sergei I Petrykiv, Gozewijn Dirk Laverman, Frederik Persson, Liffert Vogt, Peter Rossing, Martin H de Borst, Ronald T Gansevoort, Dick de Zeeuw, Hiddo J L Heerspink
BACKGROUND AND OBJECTIVES: In the treatment of CKD, individual patients show a wide variation in their response to many drugs, including renin-angiotensin-aldosterone system inhibitors (RAASi). To investigate whether therapy resistance to RAASi can be overcome by uptitrating the dose of drug, changing the mode of intervention (with drugs from similar or different classes), or lowering dietary sodium intake, we meta-analyzed individual responses to different modes of interventions. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Randomized crossover trials were analyzed to assess correlation of individual responses to RAASi and nonsteroidal anti-inflammatory drugs (NSAIDs; n=395 patients)...
November 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28983719/glucose-patterns-during-an-oral-glucose-tolerance-test-and-associations-with-future-diabetes-cardiovascular-disease-and-all-cause-mortality-rate
#16
Adam Hulman, Dorte Vistisen, Charlotte Glümer, Michael Bergman, Daniel R Witte, Kristine Færch
AIMS/HYPOTHESIS: In addition to blood glucose concentrations measured in the fasting state and 2 h after an OGTT, intermediate measures during an OGTT may provide additional information regarding a person's risk of future diabetes and cardiovascular disease (CVD). First, we aimed to characterise heterogeneity of glycaemic patterns based on three time points during an OGTT. Second, we compared the incidences of diabetes and CVD and all-cause mortality rates among those with different patterns...
October 6, 2017: Diabetologia
https://www.readbyqxmd.com/read/28932392/galectin-3-a-marker-of-cardiac-remodeling-is-inversely-related-to-serum-levels-of-marine-omega-3-fatty-acids-a-cross-sectional-study
#17
K Laake, I Seljeflot, E B Schmidt, P Myhre, A Tveit, J Norseth, H Arnesen, S Solheim
OBJECTIVE: Marine polyunsaturated n-3 fatty acids (n-3 PUFA) may have cardioprotective effects and beneficial influence on the fibrotic process. We evaluated the associations between serum marine n-3 PUFA and selected biomarkers of fibrosis and cardiac remodeling in elderly patients with acute myocardial infarction. SETTING: From the ongoing OMega-3 fatty acids in Elderly patients with Myocardial Infarction (OMEMI) trial, 299 patients were investigated. Soluble ST2 (sST2), Galectin-3 (Gal-3) and the serum content of major marine n-3 and n-6 PUFA were analyzed 2-8 weeks after the index acute myocardial infarction...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28903983/ivabradine-in-heart-failure-the-representativeness-of-shift-systolic-heart-failure-treatment-with-the-if-inhibitor-ivabradine-trial-in-a-broad-population-of-patients-with-chronic-heart-failure
#18
COMPARATIVE STUDY
Debraj Das, Gianluigi Savarese, Ulf Dahlström, Michael Fu, Jonathan Howlett, Justin A Ezekowitz, Lars H Lund
BACKGROUND: The sinus node inhibitor ivabradine was approved for patients with heart failure (HF) after the ivabradine and outcomes in chronic HF (SHIFT [Systolic Heart Failure Treatment With the IF Inhibitor Ivabradine Trial]) trial. Our objective was to characterize the proportion of patients with HF eligible for ivabradine and the representativeness of the SHIFT trial enrollees compared with those in the Swedish Heart Failure Registry. METHODS AND RESULTS: We examined 26 404 patients with clinical HF from the Swedish Heart Failure Registry and divided them into SHIFT type (left ventricular ejection fraction <40%, New York Heart Association class II-IV, sinus rhythm, and heart rate ≥70 beats per minute) and non-SHIFT type...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28894214/the-novel-compound-sul-121-preserves-endothelial-function-and-inhibits-progression-of-kidney-damage-in-type-2-diabetes-mellitus-in-mice
#19
S P H Lambooy, A Bidadkosh, D Nakladal, A van Buiten, R A T Girgis, A C van der Graaf, T J Wiedenmann, R A Koster, P Vogelaar, H Buikema, R H Henning, L E Deelman
Diabetic nephropathy is still a common complication of type 2 diabetes mellitus (T2DM) and improvement of endothelial dysfunction (ED) and inhibition of reactive oxygen species (ROS) are considered important targets for new therapies. Recently, we developed a new class of compounds (Sul compounds) which inhibit mitochondrial ROS production. Here, we tested the therapeutic effects of Sul-121 on ED and kidney damage in experimental T2DM. Diabetic db/db and lean mice were implanted with osmotic pumps delivering Sul-121 (2...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28884942/structural-properties-of-bioactive-peptides-with-%C3%AE-glucosidase-inhibitory-activity
#20
Mohammed Auwal Ibrahim, Megan J Bester, Albert W H Neitz, Anabella R M Gaspar
Bioactive peptides are emerging as promising class of drugs that could serve as α-glucosidase inhibitors for the treatment of type 2 diabetes. This article identifies structural and physicochemical requirements for the design of therapeutically-relevant α-glucosidase inhibitory peptides. So far, a total of 43 fully sequenced α-glucosidase inhibitory peptides have been reported and 13 of them had IC50 values several folds lower than acarbose. Analysis of the peptides indicates that the most potent peptides are tri- to hexapeptides with amino acids containing a hydroxyl or basic side chain at the N-terminal...
September 8, 2017: Chemical Biology & Drug Design
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