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https://www.readbyqxmd.com/read/29023170/ampa-receptors-and-perampanel-behind-selected-epilepsies-current-evidence-and-future-perspectives
#1
Carlo Di Bonaventura, Angelo Labate, Marta Maschio, Stefano Meletti, Emilio Russo
The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission, and are critical for synchronization and spread of epileptic activity. Areas covered. AMPA receptor antagonists have been also developed as antiepileptic drugs and perampanel (PER) is the first highly selective, non-competitive AMPA-type glutamate receptor antagonist that is available on the market. It is approved as adjunctive therapy for the treatment of partial-onset seizures with or without secondary generalization, and for primary generalized tonic-clonic seizures in idiopathic generalized epilepsy, in patients aged ≥ 12 years...
October 12, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29016809/longitudinal-assessment-of-late-onset-neurologic-conditions-in-survivors-of-childhood-central-nervous-system-tumors-a-childhood-cancer-survivor-study-report
#2
Elizabeth M Wells, Nicole J Ullrich, Kristy Seidel, Wendy Leisenring, Charles A Sklar, Gregory T Armstrong, Lisa Diller, Allison King, Kevin R Krull, Joseph P Neglia, Marilyn Stovall, Kimberly Whelan, Kevin C Oeffinger, Leslie L Robison, Roger J Packer
Background: Survivors of childhood central nervous system (CNS) tumors experience high rates of treatment-related neurologic sequelae. Whether survivors continue to be at increased risk for new events as they age is unknown. Methods: Adverse neurologic health conditions in 5-year survivors of CNS tumors from the Childhood Cancer Survivor Study (CCSS, n=1876) were evaluated longitudinally at a median 23.0 years from diagnosis, range 5.1 - 38.9; median age at last evaluation 30...
August 22, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28993874/prognosis-of-patients-with-primary-malignant-brain-tumors-admitted-to-the-intensive-care-unit-a-two-decade-experience
#3
Maxens Decavèle, Nicolas Weiss, Isabelle Rivals, Hélène Prodanovic, Ahmed Idbaih, Julien Mayaux, Thomas Similowski, Alexandre Demoule
The purpose of this study is to describe the reasons for ICU admission and to evaluate the outcome and prognostic factors of patients with primary malignant brain tumors (PMBT) admitted to the intensive care unit (ICU). This is a retrospective observational cohort study of 196 PMBT patients admitted to two ICUs over a 19-year period. Acute respiratory failure was the main reason for ICU admission (45%) followed by seizures (25%) and non-epileptic coma (14%). Seizures were more common in patients with glial lesions (84 vs...
October 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28989538/erratum-efficacy-and-tolerability-of-lacosamide-for-secondary-epileptic-seizures-in-patients-with-brain-tumor-a-multicenter-observational-retrospective-study
#4
Juan Manuel Sepúlveda-Sánchez, Antonio Conde-Moreno, Manuel Barón, Javier Pardo, Gaspar Reynés, Antonio Belenguer
[This corrects the article DOI: 10.3892/ol.2017.5988.].
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28983585/complex-role-of-connexin-43-in-astrocytic-tumors-and-possible-promotion-of-glioma%C3%A2-associated-epileptic-discharge-review
#5
Hui Dong, Xing-Wang Zhou, Xiang Wang, Yuan Yang, Jie-Wen Luo, Yan-Hui Liu, Qing Mao
Connexin (Cx)43 is a multifunction protein which forms gap junction channels and hemi‑channels. It also contains abundant binding domains which possess the ability to interact with certain Cx43‑associated proteins and therefore serve a fundamental role in various physiological and pathological functions. However, the understanding of the association between cancer and Cx43 along with Cx43‑gap junctions (GJ) remains unclear. All available data illustrate that Cx43 and its associated GJ serve important functions in cancers...
September 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28977690/neuroinflammatory-pathways-as-treatment-targets-and-biomarker-candidates-in%C3%A2-epilepsy-emerging-evidence-from-preclinical-and-clinical-studies
#6
Erwin A van Vliet, Eleonora Aronica, Annamaria Vezzani, Teresa Ravizza
Accumulating evidence indicates an important pathophysiological role of brain inflammation in epilepsy. In this review, we will provide an update of specific inflammatory pathways that have been proposed to be crucial in the underlying molecular mechanisms of epilepsy, including the interleukin-1 receptor/toll-like receptor signaling, cyclooxygenase-2, tumor necrosis factor-alpha, complement signaling and chemokines. Furthermore, by drawing on evidence from preclinical and clinical studies we will discuss the potential of these signaling pathways targets for novel therapeutic interventions that control drug-resistant seizures or have disease-modifying effects...
October 4, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28974152/encephalitis-with-antibodies-against-the-gabab-receptor-seizures-as-the-most-common-presentation-at-admission
#7
Xueping Chen, Fan Liu, Jin-Mei Li, Xiao-Qi Xie, Qiong Wang, Dong Zhou, Huifang Shang
OBJECTIVE: Autoimmune encephalitis associated with antibodies against gamma-aminobutyric-acid B receptor (GABABR) has not been described in detail in Chinese patients. METHODS: Patients with anti-GABABR encephalitis treated between January 2013 and December 2015 were analyzed in terms of clinical characteristics, laboratory findings, tumor presence, autoantibody patterns, treatment response and outcomes. RESULTS: Eleven patients were identified (male, N = 8; female, N = 3), with the median age of 51 years...
November 2017: Neurological Research
https://www.readbyqxmd.com/read/28973391/postoperative-epileptic-seizures-in-children-is-the-brain-incision-a-risk-factor
#8
Luca Massimi, Domenica Battaglia, Federico Bianchi, Simone Peraio, Elisabetta Peppucci, Concezio Di Rocco
BACKGROUND: Postoperative seizures (PSs) after neurosurgical operations are common but little is known about the role of surgical brain incision on their genesis. This topic has not been addressed so far. OBJECTIVE: To verify if the corticotomy affects the risk of PSs and postoperative epilepsy (PE) in children. METHODS: One hundred forty-three consecutive pediatric cases operated on for supratentorial lesions at the same institution in the last 15 yr have been retrospectively reviewed by dividing them into group A, 68 children who required brain corticotomy mainly for hemispheric tumors, and group B, 75 children treated through extracortical approaches mainly for suprasellar and optic tumors...
July 7, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28926844/atypical-presentation-of-a-pediatric-cerebellar-ganglioglioma
#9
Richard Bram, Roberta J Seidman, David Chesler
BACKGROUND/AIMS: Gangliogliomas (GGs) are rare central nervous system tumors occurring primarily in the supratentorial compartment with infratentorial instances most often involving the brain stem. Infratentorial GGs typically present with signs and symptoms of increased intracranial pressure (ICP), cranial nerve deficits, or focal cerebellar findings; rarely, these tumors have been associated with focal seizures. METHODS: In this report, we describe an atypical presentation of a cerebellar GG in a 20-month-old male who initially presented with syncope and emesis in the absence of electrographic evidence of seizures, radiographic evidence of hydrocephalus, or elevated ICP...
September 20, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28926420/seronegative-paraneoplastic-limbic-encephalitis-associated-with-thymoma
#10
Jaime Toro, David Cuellar-Giraldo, Alejandra Duque, Karla Minota, Jorge Patiño, Manuel García
Paraneoplastic limbic encephalitis is an autoimmune syndrome characterized by the acute or subacute onset of encephalopathy, memory loss, confusion, temporal lobe seizures, and behavioral and mood changes. Although most patients with paraneoplastic limbic encephalitis have antineuronal antibodies, advances in the field now permit the diagnosis without autoantibody test results. In this case illustrating the new diagnostic criteria, we report a 70-year-old woman who was brought to the emergency room after the acute onset of cognitive impairment, altered mental status, and choreoathetoid movements...
September 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28883682/role-of-mri-in-diagnosis-of-ruptured-intracranial-dermoid-cyst
#11
Sefedin Muçaj, Mehmet Sahin Ugurel, Kreshnike Dedushi, Naser Ramadani, Naim Jerliu
INTRODUCTION: Intracranial dermoid cystic tumors account for <1% of all intracranial masses. CASE REPORT: A 52-year-old male, having headaches, nausea and is presented with a history of 2 episodes of new onset seizures. On presentation, the patient had a normal physical exam, including a complete neurological and cranial nerve exam. METHODS: Precontrast MRI; TSE/T2Wsequence in axial/coronal planes; 3D - HI-resolution T1W sagittal; FLAIR/T2W axial; FLAIR/T2W, Flash/T2W oblique coronal plane, GRE/T2W axial...
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28882861/real-time-motor-cortex-mapping-for-the-safe-resection-of-glioma-an-intraoperative-resting-state-fmri-study
#12
T-M Qiu, F-Y Gong, X Gong, J-S Wu, C-P Lin, B B Biswal, D-X Zhuang, C-J Yao, X-L Zhang, J-F Lu, F-P Zhu, Y Mao, L-F Zhou
BACKGROUND AND PURPOSE: Resting-state functional MR imaging has been used for motor mapping in presurgical planning but never used intraoperatively. This study aimed to investigate the feasibility of applying intraoperative resting-state functional MR imaging for the safe resection of gliomas using real-time motor cortex mapping during an operation. MATERIALS AND METHODS: Using interventional MR imaging, we conducted preoperative and intraoperative resting-state intrinsic functional connectivity analyses of the motor cortex in 30 patients with brain tumors...
September 7, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28868193/cervical-cancer-metastasis-to-the-brain-a-case-report-and-review-of-literature
#13
REVIEW
Kaleigh Fetcko, Dibson D Gondim, Jose M Bonnin, Mahua Dey
BACKGROUND: Intracranial metastasis from cervical cancer is a rare occurrence. METHODS: In this study we describe a case of cervical cancer metastasis to the brain and perform an extensive review of literature from 1956 to 2016, to characterize clearly the clinical presentation, treatment options, molecular markers, targeted therapies, and survival of patients with this condition. RESULTS: An elderly woman with history of cervical cancer in remission, presented 2 years later with a right temporo-parietal tumor, which was treated with surgery and subsequent stereotactic radiosurgery (SRS) to the resection cavity...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28832891/outcome-of-cancer-related-seizures-in-patients-treated-with-lacosamide
#14
M Toledo, A Molins, M Quintana, E Santamarina, F Martinez-Ricarte, E Martínez-Saez, J Salas-Puig
OBJECTIVES: Lacosamide is an antiepileptic drug (AED), which has proven to be effective to control seizures, including acute conditions such as status epilepticus. The aim of this study is to describe the clinical experience with lacosamide in neuro-oncological patients. MATERIALS AND METHODS: Multicenter retrospective study in patients with cancer-related seizures, who received lacosamide as an add-on therapy. RESULTS: Forty-eight patients with benign and malignant tumors, including primary brain tumors, lymphomas, systemic cancer with central nervous system involvement, or paraneoplastic encephalitis, were included...
August 22, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28828136/stroke-like-migraine-attacks-after-radiation-therapy-syndrome-a-case-report-and-literature-review
#15
Andrew Ian Goldfinch, Timothy John Kleinig
Stroke-like migraine attacks after radiation therapy syndrome is a late complication of cranial radiation. It typically presents as reversible, unilateral cortical signs and symptoms such as confusion, hemiparesis, seizures, and headaches. Magnetic resonance imaging is also required for diagnosis, demonstrating cortical linear gadolinium enhancement. Typically, these magnetic resonance imaging findings resolve as patients experience partial or complete improvement in their symptoms and signs after a few weeks...
September 2017: Radiology case reports
https://www.readbyqxmd.com/read/28818811/brain-tumors-and-epileptic-spasms-natural-history-and-outcomes
#16
Viviana Benitez, Peter E Manley, Liliana C Goumnerova, Chellamani Harini, Nicole J Ullrich
While brain tumors are a frequent cause of seizures, they rarely cause epileptic spasms (ES). The objective of this study was to investigate features of tumor-associated ES. We conducted a retrospective review of patients with ES and a brain tumor. Demographics; pathologic, radiologic, and EEG data; treatment response; and long-term outcome were collected. Twenty four patients were identified; 11 met inclusion criteria. Epileptic spasm (ES) onset occurred prior to tumor diagnosis in seven patients (63%), and after tumor resection in 4 patients (36%)...
August 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28808901/the-utility-of-routine-intensive-care-admission-for-patients-undergoing-intracranial-neurosurgical-procedures-a-systematic-review
#17
Cesar Cimonari de Almeida, M Dustin Boone, Yosef Laviv, Burkhard S Kasper, Clark C Chen, Ekkehard M Kasper
BACKGROUND: Patients who have undergone intracranial neurosurgical procedures have traditionally been admitted to an intensive care unit (ICU) for close postoperative neurological observation. The purpose of this study was to systematically review the evidence for routine ICU admission in patients undergoing intracranial neurosurgical procedures and to evaluate the safety of alternative postoperative pathways. METHODS: We were interested in identifying studies that examined selected patients who presented for elective, non-emergent intracranial surgery whose postoperative outcomes were compared as a function of ICU versus non-ICU admission...
August 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28808765/presentation-and-symptom-interval-in-children-with-central-nervous-system-tumors-a-single-center-experience
#18
Chiara Stocco, Chiara Pilotto, Eva Passone, Agostino Nocerino, Raffaello Tosolini, Anna Pusiol, Paola Cogo
PURPOSE: The aim of this study is to describe the symptoms and signs of central nervous system (CNS) tumors in a pediatric population and to assess the time interval between the onset of the disease and the time of the diagnosis. METHODS: A retrospective observational study was conducted at our Oncology Pediatric Unit between January 2000 and November 2011. We included 75 children between 5 months and 16 years (mean age of 7.8 ± 4.7 years), with male to female ratio of 3:2...
August 14, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28804045/unusual-magnetic-resonance-imaging-findings-of-a-glioblastoma-arising-during-treatment-with-lenvatinib-for-thyroid-cancer
#19
Nobuhiko Arai, Hikaru Sasaki, Ryota Tamura, Kentarou Obara, Kazunari Yoshida
BACKGROUND: Glioblastoma (GBM) is radiologically characterized by magnetic resonance imaging (MRI) findings, such as ring enhancement with extensive perifocal edema and a butterfly appearance extending into the bilateral lobes. However, these characteristic findings could be changed by anti-angiogenic therapy, with decreased contrast enhancement and improved perifocal edema. Herein, we report a case of glioblastoma that arose during treatment with a tyrosine kinase inhibitor for another cancer...
August 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28799062/long-term-epilepsy-associated-tumor-in-the-amygdala-of-a-16-year-old-boy-report-of-a-rare-case-having-intranuclear-filaments
#20
Yoon Jin Cha, Dong-Seok Kim, Seung-Koo Lee, Hoon-Chul Kang, Se Hoon Kim
The term "long-term epilepsy-associated tumor (LEAT)" encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia...
August 10, 2017: Brain Tumor Pathology
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