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https://www.readbyqxmd.com/read/28087392/predictors-and-mechanisms-of-epilepsy-occurrence-in-cerebral-gliomas-what-to-look-for-in-clinicopathology
#1
Cheng Huang, Xiao-Sa Chi, Xin Hu, Ni Chen, Qiao Zhou, Dong Zhou, Jin-Mei Li
Gliomas, especially low-grade gliomas, are highly epileptogenic brain tumors. Histopathological information is valuable in evaluating the diagnosis and/or biologic behavior of various gliomas. Here we explored the clinical data and histopathological predictors of the occurrence of epilepsy in patients with gliomas. A retrospective study examined 310 consecutive patients who had undergone surgical treatment for gliomas in our institution from January 2013 to January 2015. Clinical data and pathological examination results were analyzed...
January 11, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28068234/radiation-dose-dependent-hippocampal-atrophy-detected-with-longitudinal-volumetric-magnetic-resonance-imaging
#2
Tyler M Seibert, Roshan Karunamuni, Hauke Bartsch, Samar Kaifi, Anitha Priya Krishnan, Yoseph Dalia, Jeffrey Burkeen, Vyacheslav Murzin, Vitali Moiseenko, Joshua Kuperman, Nathan S White, James B Brewer, Nikdokht Farid, Carrie R McDonald, Jona A Hattangadi-Gluth
PURPOSE: After radiation therapy (RT) to the brain, patients often experience memory impairment, which may be partially mediated by damage to the hippocampus. Hippocampal sparing in RT planning is the subject of recent and ongoing clinical trials. Calculating appropriate hippocampal dose constraints would be improved by efficient in vivo measurements of hippocampal damage. In this study we sought to determine whether brain RT was associated with dose-dependent hippocampal atrophy. METHODS AND MATERIALS: Hippocampal volume was measured with magnetic resonance imaging (MRI) in 52 patients who underwent fractionated, partial brain RT for primary brain tumors...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28061403/berberine-ameliorates-intrahippocampal-kainate-induced-status-epilepticus-and-consequent-epileptogenic-process-in-the-rat-underlying-mechanisms
#3
Reza Sedaghat, Yosra Taab, Zahra Kiasalari, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Status epilepticus (SE) is a life-threatening neurologic condition, instigating epileptogenesis to transform normal brain to an epileptic condition. SE is followed by spontaneous recurrent seizures (SRS) and final development of temporal lobe epilepsy (TLE) that is resistant to treatment. Neuroprotective strategies are increasingly put forward as a promising therapy to prevent and/or manage epileptic conditions. In this study, we investigated whether berberis alkaloid, i.e. berberine (BBR), could ameliorate intrahippocampal kainate-induced SE and its consequent epileptogenic process and to explore some underlying mechanisms...
January 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28059647/simulating-vasogenic-brain-edema-using-chronic-vegf-infusion
#4
Martin Piazza, Jeeva Munasinghe, Roger Murayi, Nancy Edwards, Blake Montgomery, Stuart Walbridge, Marsha Merrill, Prashant Chittiboina
OBJECTIVE To study peritumoral brain edema (PTBE), it is necessary to create a model that accurately simulates vasogenic brain edema (VBE) without introducing a complicated tumor environment. PTBE associated with brain tumors is predominantly a result of vascular endothelial growth factor (VEGF) secreted by brain tumors, and VEGF infusion alone can lead to histological blood-brain barrier (BBB) breakdown in the absence of tumor. VBE is intimately linked to BBB breakdown. The authors sought to establish a model for VBE with chronic infusion of VEGF that can be validated by serial in-vivo MRI and histological findings...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28043238/recurrent-ataxia-in-children-and-adolescents
#5
Michael S Salman, Samantha F Klassen, Janine L Johnston
BACKGROUND: Recurrent ataxia is encountered infrequently in clinical pediatric neurology practise and presents with diagnostic challenges. It is caused by several disorders. Our aims were to describe the epidemiology and clinical features in children with recurrent ataxia. MATERIALS AND METHODS: A retrospective review was undertaken in 185 children with chronic ataxia, who presented during 1991 to 2008. Several databases were searched to ensure optimum ascertainment...
January 3, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28041673/epilepsy-related-brain-tumors
#6
Özdem Ertürk Çetin, Cihan İşler, Mustafa Uzan, Çiğdem Özkara
Seizures are among the most common presentations of brain tumors. Several tumor types can cause seizures in varying rates; neuroglial tumors and the gliomas are the most common ones. Brain tumors are the second most common cause of focal intractable epilepsy in epilepsy surgery series, with the highest frequency being dysembryoplastic neuroepithelial tumors and gangliogliomas. Seizure management is an important part of the treatment of patients with brain tumors. This review discusses clinical features and management of seizures in patients with brain tumors, including, neuroglial tumors, gliomas, meningioma and metastases; with the help of recent literature data...
December 21, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28039368/long-term-neurologic-health-and-psychosocial-function-of-adult-survivors-of-childhood-medulloblastoma-pnet-a-report-from-the-childhood-cancer-survivor-study
#7
Allison A King, Kristy Seidel, Chongzhi Di, Wendy M Leisenring, Stephanie Mabry Perkins, Kevin R Krull, Charles A Sklar, Daniel M Green, Gregory T Armstrong, Lonnie K Zeltzer, Elizabeth Wells, Marilyn Stovall, Nicole J Ullrich, Kevin C Oeffinger, Leslie L Robison, Roger J Packer
BACKGROUND: Medulloblastoma is the most common malignant childhood brain tumor, although long-term risks for chronic neurologic health and psychosocial functioning in aging adult survivors are incompletely characterized. METHODS: The Childhood Cancer Survivor Study (CCSS) includes 380 five-year survivors of medulloblastoma/primitive neuroectodermal tumor (PNET; median age at follow-up: 30 y, interquartile range 24-36) and sibling comparison (n = 4031). Cumulative incidence of neurologic health conditions was reported...
December 29, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28028533/extracellular-electrical-recording-of-ph-triggered-bursts-in-c6-glioma-cell-populations
#8
Paulo R F Rocha, Maria C R Medeiros, Ulrike Kintzel, Johannes Vogt, Inês M Araújo, Ana L G Mestre, Volker Mailänder, Paul Schlett, Melanie Dröge, Leonid Schneider, Fabio Biscarini, Dago M de Leeuw, Henrique L Gomes
Glioma patients often suffer from epileptic seizures because of the tumor's impact on the brain physiology. Using the rat glioma cell line C6 as a model system, we performed long-term live recordings of the electrical activity of glioma populations in an ultrasensitive detection method. The transducer exploits large-area electrodes that maximize double-layer capacitance, thus increasing the sensitivity. This strategy allowed us to record glioma electrical activity. We show that although glioma cells are nonelectrogenic, they display a remarkable electrical burst activity in time...
December 2016: Science Advances
https://www.readbyqxmd.com/read/28027874/deep-brain-stimulation-of-the-anterior-nucleus-of-the-thalamus-reverses-the-gene-expression-of-cytokines-and-their-receptors-as-well-as-neuronal-degeneration-in-epileptic-rats
#9
Ying-Chuan Chen, Guan-Yu Zhu, Xiu Wang, Lin Shi, Yin Jiang, Xin Zhang, Jian-Guo Zhang
BACKGROUND: Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) is effective in seizure control. However, the mechanisms remain unclear. METHODS: Sixty-four rats were randomly assigned to the control group, the kainic acid (KA) group, the sham-DBS group and the DBS group. Video-electroencephalogram (EEG) was used to monitor seizures. Quantitative real time PCR (qPCR) was applied for detecting interleukin-1 beta (IL-1β), IL-1 receptor (IL-1R), IL-6, IL-6 receptor (IL-6R), gp130, tumor necrosis factor-alpha (TNF-α), TNF-receptor 1 (TNF-R1) and TNF-receptor 2 (TNF-R2) expression 12 hours after the establishment of an epileptic model...
December 24, 2016: Brain Research
https://www.readbyqxmd.com/read/28018467/a-rare-case-of-dysembryoplastic-neuroepithelial-tumor-combined-with-encephalocraniocutaneous-lipomatosis-and-intractable-seizures
#10
Jee-Yeon Han, Mi-Sun Yum, Eun-Hee Kim, Seokho Hong, Tae-Sung Ko
Encephalocraniocutaneous lipomatosis (ECCL) is a rare neurocutaneous syndrome that affects ectomesodermal tissues (skin, eyes, adipose tissue, and brain). The neurologic manifestations associated with ECCL are various including seizures. However, ECCL patients very rarely develop brain tumors that originate from the neuroepithelium. This is the first described case of ECCL in combination with dysembryoplastic neuroepithelial tumor (DNET) that presented with intractable seizures. A 7-year-old girl was admitted to our center because of ECCL and associated uncontrolled seizures...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28018457/relapsed-wilms-tumor-with-multiple-brain-metastasis
#11
Akın Akakın, Baran Yılmaz, Murat Şakir Ekşi, Özlem Yapıcıer, Türker Kılıç
Wilms' tumor is the most common malignant renal tumor in childhood. The brain metastasis of a Wilms' tumor with anaplastic histopathology is rare. We present the case of an 8-year-old girl with Wilms' tumor, who presented with multiple brain metastases 5 years after her primary diagnosis. The brain masses were diagnosed after a generalized tonic-clonic seizure attack. The big solid mass in the cerebellum was resected, and whole-brain radiotherapy was performed, after which, she succumbed to her disease. In the case of clinical suspicion, cranial surveillance should be included in the routine clinical work-up for Wilms' tumor...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28017579/seizures-caused-by-brain-tumors-in-children
#12
Iván Sánchez Fernández, Tobias Loddenkemper
PURPOSE: To review the epidemiology, clinical features, and treatment of seizures secondary to pediatric brain tumors. METHOD: Literature review. RESULTS: Pediatric brain tumors are the most common solid pediatric tumor and the most common cause of death in pediatric cancer. Seizures are one of the most common symptoms of pediatric brain tumors. Factors associated with increased risk of seizures include supratentorial location, gray matter involvement, low-grade, and certain histological features-especially dysembryoplastic neuroepithelial tumor, ganglioglioma, and oligodendroglioma...
December 7, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27992000/refractory-epilepsy-in-children-with-brain-tumors-the-urgency-of-neurosurgery
#13
Marília Rosa Abtibol Bernardino, Carolina Funayama, Ana Paula Andrade Hamad, Hélio Machado, Américo Sakamoto, Ursula Thome, Vera Cristina Terra, Antonio Carlos Dos Santos
In order to verify indications for surgery, 27 patients with refractory epileptic seizures and brain tumor, aged up to 19 years at the time of surgery, were studied between 1996 and 2013 and followed up for at least one year. The mean interval between the onset of seizures and the diagnosis of the tumor was 3.6 years, and from diagnosis to the surgery, 18 months. The location of the tumor was in the temporal lobe in 16, with ganglioglioma and dysembryoplastic neuroepithelial tumors being the most frequent. Among the patients, 92...
December 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27989972/frontal-lobe-decortication-frontal-lobectomy-with-ventricular-preservation-in-epilepsy-part-1-anatomical-landmarks-and-surgical-technique
#14
Hung Tzu Wen, Leila Maria Da Róz, Albert L Rhoton, Luiz Henrique Martins Castro, Manoel Jacobsen Teixeira
BACKGROUND: An extensive frontal resection is a frequently performed neurosurgical procedure, especially for treating brain tumor and refractory epilepsy. However, there is paucity of reports available regarding its surgical anatomy and technique. OBJECTIVES: To present the anatomical landmarks and surgical technique of the frontal lobe decortication (FLD) in epilepsy. The goals are to maximize the gray matter removal, spare primary and supplementary motor areas, and preserving frontal horn...
October 27, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27984807/braf-v600e-mutation-in-epilepsy-associated-glioneuronal-tumors-prevalence-and-correlation-with-clinical-features-in-a-chinese-population
#15
Yin-Xi Zhang, Chun-Hong Shen, Yi Guo, Yang Zheng, Jun-Ming Zhu, Yao Ding, Ye-Lei Tang, Shuang Wang, Mei-Ping Ding
PURPOSE: Glioneuronal tumors (GNTs) are the most common histological type of brain tumors in patients who received epilepsy surgery, and part of them presented with BRAF V600E mutation. We aimed to verify the presence of the BRAF V600E mutation in epilepsy-associated GNTs from Chinese population and evaluate the association with clinical features. METHODS: Data from 35 patients diagnosed with GNTs, including 24 gangliogliomas and 11 dysembryoplastic neuroepithelial tumors, were retrospectively collected...
December 9, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27939100/single-pulse-electrical-stimulation-to-probe-functional-and-pathological-connectivity-in-epilepsy
#16
Riki Matsumoto, Takeharu Kunieda, Dileep Nair
In the last decade, single pulse electrical stimulation (SPES) has been used as an investigational tool in the field of epilepsy surgery. Direct cortical stimulation applied at a frequency of ∼1Hz can probe cortico-cortical connections by averaging electrocorticogram time-lock to the stimuli (2×20-30 trials). These evoked potentials that emanate from adjacent and remote cortices have been termed cortico-cortical evoked potentials (CCEPs). Although limited to patients undergoing invasive presurgical evaluations with intracranial electrodes, CCEP provides a novel way to explore inter-areal connectivity in vivo in the living human brain to probe functional brain networks such as language and cognitive motor networks...
November 14, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27924180/magnetic-resonance-spectroscopy-and-single-photon-emission-computed-tomography-in-the-evaluation-of-cerebral-tumors-a-case-report
#17
Ioannis Siasios, Varvara Valotassiou, Eftychia Kapsalaki, Ioannis Tsougos, Panagiotis Georgoulias, Aggeliki Fotiadou, Maria Ioannou, Georgios Koukoulis, Vassilios Dimopoulos, Kostas Fountas
In their daily clinical practice, physicians have to confront diagnostic dilemmas which cannot be resolved by the application of only one imaging technique. In this case report, we present a 66-year-old woman who was admitted to our institution for the surgical resection of a recently diagnosed brain tumor. The patient had a history of epileptic seizures and was hospitalized in the past for anti-phospholipid syndrome related to a non-Hodgkin lymphoma in remission. Magnetic resonance imaging (MRI) examination revealed an enhancing right parasagittal lesion with significant edema suggestive of a high grade glioma...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27917338/six-different-extremely-calcified-lesions-of-the-brain-brain-stones
#18
Yurdal Gezercan, Vedat Acik, Gökhan Çavuş, Ali Ihsan Ökten, Emre Bilgin, Hakan Millet, Burak Olmaz
BACKGROUND: This study aimed to extend clinical documentation of cerebral calculi by reporting six cases of cerebral calculi with distinct etiologies and localizations. METHODS: We evaluated the age, sex distribution, presenting symptoms, neurological examination findings, pathology results, and location of the calcifications of six patients with intracranial calcifications. RESULTS: Three of the six patients with brain stones were female (50%), and three were male (50%)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27909971/gastrodin-attenuates-pentylenetetrazole-induced-seizures-by-modulating-the-mitogen-activated-protein-kinase-associated-inflammatory-responses-in-mice
#19
Liming Chen, Xinan Liu, Hua Wang, Min Qu
Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata ("Tianma"), has a long history in the treatment of epilepsy and other neurological disorders. However, the molecular mechanisms are not clear. Here, we found that gastrodin ameliorated pentylenetetrazole (PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice. Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1β and tumor necrosis factor-α while increasing interleukin-10, an anti-inflammatory cytokine in the brain...
December 1, 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27893285/recent-advances-in-subtyping-tumors-of-the-central-nervous-system-using-molecular-data
#20
Jens Schittenhelm
Primary brain tumors account for substantial morbidity and mortality. They often infiltrate the brain diffusely, continue growing, and cause adverse events, such as headaches, seizures, and neurological deficits. The classification of primary brain tumors, based for decades on histology, has been fundamentally changed by the World Health Organization in 2016 by incorporation of molecular data. Areas covered: Literature from glioblastomas, high- and low-grade astrocytic, oligodendroglial, glioneuronal and ependymal tumors from the last five years were reviewed...
January 2017: Expert Review of Molecular Diagnostics
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