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Brain tumor seizure

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https://www.readbyqxmd.com/read/29454130/abscess-within-a-glioblastoma-mimicking-a-matryoshka-doll
#1
Kislay Kishore, Manish Beniwal, Shilpa Rao, K V L N Rao, Vikas Vazhayil, Dwarkanath Srinivas, Sampath Somanna
BACKGROUND: Abscess co-existing within a brain tumor is a rare entity. Case reports in literature primarily consist of sellar pathology and parenchymal lesions including meningioma, glioma, and metastases. We report a case of glioblastoma with an intra-tumoral abscess in a middle-aged lady with no prior invasive procedure or systemic focus of infection. CASE DESCRIPTION: A 45-year old lady presented with new onset generalized seizures and rapidly progressive left hemiparesis...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452315/technical-aspects-of-awake-craniotomy-with-mapping-for-brain-tumors-in-a-limited-resource-setting
#2
Rafael Teixeira Magalhaes Leal, Bruno Mendonça Barcellos, Jose Alberto Landeiro
BACKGROUND: Brain tumor surgery near or within eloquent regions is increasingly common and is associated with a high risk of neurological injury. Awake craniotomy with mapping has been shown to be a valid method to preserve neurological function while increasing the extent of resection. However, the technique used varies greatly among centers. Most count on professionals such as neuropsychologists, speech therapists, neurophysiologists or neurologists to help in intraoperative patient evaluation...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29442232/neuroimaging-of-first-seizure-in-the-adult-emergency-patients
#3
Kerem Ozturk, Esra Soylu, Cem Bilgin, Bahattin Hakyemez, Mufit Parlak
The aim is to establish the role of head computed tomography (CT) and magnetic resonance imaging (MRI) in adults presenting to the emergency department (ED) with first-time seizure (FS) and to analyze the potential predictor variables for the adverse imaging outcome. We retrospectively reviewed the medical records of all adults who underwent cranial CT or MRI between January 1, 2011, and December 1, 2016, to an academic ED for FS. Patients were excluded if were under 18 years of age, had known recent intracranial pathology, known brain tumor or having a history of trauma...
February 13, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29441072/fatal-necrotizing-encephalopathy-after-treatment-with-nivolumab-for-squamous-non-small-cell-lung-cancer-case-report-and-review-of-the-literature
#4
Markus Leitinger, Mihael V Varosanec, Slaven Pikija, Romana E Wass, Dave Bandke, Serge Weis, Michael Studnicka, Susanne Grinzinger, Mark R McCoy, Larissa Hauer, Johann Sellner
Immune checkpoint inhibitors are antibodies, which enhance cellular and humoral immune responses and are approved for the treatment of various tumors. Immune-related adverse events (irAE) involving different organs and systems are, however, among the side-effects. Recent reports of severe persistent neurological deficits and even fatal cases underpin the need for better understanding of the exact pathomechanisms of central nervous system (CNS) toxicity. To our knowledge, we report the first biopsy-proven case of fatal necrotizing encephalopathy after treatment with nivolumab...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29410648/status-epilepticus-behavioral-and-electroencephalography-seizure-correlates-in-kainate-experimental-models
#5
REVIEW
Shaunik Sharma, Sreekanth Puttachary, Achala Thippeswamy, Anumantha G Kanthasamy, Thimmasettappa Thippeswamy
Various etiological factors, such as head injury, chemical intoxication, tumors, and gene mutation, can induce epileptogenesis. In animal models, status epilepticus (SE) triggers epileptogenesis. In humans, convulsive SE for >30 min can be a life-threatening medical emergency. The duration and severity of convulsive SE are highly variable in chemoconvulsant animal models. A continuous video-electroencephalography (EEG) recording, and/or diligent direct observation, facilitates quantification of exact duration of different stages of convulsive seizures (Racine stages 3-5) to determine the severity of SE...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29393419/hmgb1-mediates-microglia-activation-via-the-tlr4-nf-%C3%AE%C2%BAb-pathway-in-coriaria-lactone-induced-epilepsy
#6
Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Miao
Epilepsy is a chronic and recurrent disease of the central nervous system, with a complex pathology. Recent studies have demonstrated that the activation of glial cells serve an important role in the development of epilepsy. The objective of the present study was to investigate the role of high‑mobility group box‑1 (HMGB1) in mediating the activation of glial cells through the toll‑like receptor 4 (TLR4)/nuclear factor (NF)‑κB signaling pathway in seizure, and the underlying mechanism. The brain tissue of post‑surgery patients with intractable epilepsy after resection and the normal control brain tissue of patients with craniocerebral trauma induced intracranial hypertension were collected...
January 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29386275/risk-for-injuries-and-accidents-in-epilepsy-a-prospective-population-based-cohort-study
#7
Benno Mahler, Sofia Carlsson, Tomas Andersson, Torbjörn Tomson
OBJECTIVE: To study the risk for injuries/accidents in people with newly diagnosed epileptic seizures in relation to comorbidities. METHODS: Between September 1, 2001, and August 31, 2008, individuals in northern Stockholm with incident unprovoked seizures (epilepsy; n = 2,130) were included in a registry. For every epilepsy patient, 8 individuals matched for sex and inclusion year (n = 16,992) were randomly selected as references from the population of the catchment area...
January 31, 2018: Neurology
https://www.readbyqxmd.com/read/29384930/multiple-cerebral-gliomas-mimicking-central-nervous-system-inflammatory-demyelinating-diseases-a-rare-case-with-review-of-literature
#8
Yong-Jie Xiong, Xin-Ling Zhao, Xiao-Yan Wang, Deng-Ji Pan, Dai-Shi Tian
RATIONALE: Multiple cerebral gliomas (MCGs), usually classified into multifocal and multicentric subtypes, represent major diagnostic challenges as their clinical, radiologic, and pathohistological features are not uniform, often mimicking brain metastatic tumors or central nervous system inflammatory demyelinating diseases (IDD). PATIENT CONCERNS: Here, we report a rare case of MCGs with isolated seizures and 4 lesions in the brain, that was initially misdiagnosed as IDD during treatment...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29378663/early-diagnosis-of-tuberous-sclerosis-complex-a-race-against-time-how-to-make-the-diagnosis-before-seizures
#9
Monika Słowińska, Sergiusz Jóźwiak, Angela Peron, Julita Borkowska, Dariusz Chmielewski, Krzysztof Sadowski, Elżbieta Jurkiewicz, Aglaia Vignoli, Francesca La Briola, Maria Paola Canevini, Katarzyna Kotulska-Jóźwiak
BACKGROUND: Tuberous sclerosis complex (TSC) is a genetic disorder with an incidence of 1:6000 live births and associated with the development of benign tumors in several organs. It is also characterized by high rates of neurological and neuropsychiatric abnormalities, including epilepsy affecting 70-90% of patients and being one of the major risk factors of intellectual disability. The first seizures in TSC patients appear usually between the 4th and the 6th months of life. Recent studies have shown the beneficial role of preventative antiepileptic treatment in TSC patients, with the possibility for improvement of cognitive outcome...
January 29, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29362283/-a-case-of-primary-intracranial-epithelioid-hemangioendothelioma
#10
Fukuko Yamamoto, Hironori Yamagiwa, Fuminori Iwamoto, Tsutomu Kasugai
Epithelioid hemangioendotheliomas(EHEs)most commonly occur in the liver, lung, bone, and soft tissues, but rarely in the brain. Here, we describe a case of primary intracranial epithelioid hemangioendothelioma manifested by an epileptic attack. A 53-year-old woman with no previous convulsive history presented at our hospital after experiencing a seizure. Magnetic resonance imaging revealed a mass in her right frontal lobe, with edema, which was well enhanced with gadolinium. Systemic computed tomography, on the other hand, did not show any tumor involvement in other organs...
January 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29350351/convection-enhanced-delivery-of-cetuximab-conjugated-iron-oxide-nanoparticles-for-treatment-of-spontaneous-canine-intracranial-gliomas
#11
A Courtenay Freeman, Simon R Platt, Shannon Holmes, M Kent, Kelsey Robinson, Elizabeth Howerth, Joe Eagleson, Alexandros Bouras, Milota Kaluzova, Constantinos G Hadjipanayis
Cetuximab conjugated iron-oxide nanoparticles (cetuximab-IONPs) have shown both in-vitro and in-vivo anti-tumor efficacy against gliomas. The purpose of this pilot study was to evaluate the safety and potential efficacy of cetuximab-IONPs for treatment of spontaneously occurring intracranial gliomas in canines after convection-enhanced delivery (CED). The use of CED allowed for direct infusion of the cetuximab-IONPs both intratumorally and peritumorally avoiding the blood brain barrier (BBB) and limiting systemic effects...
January 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29313510/need-for-surgical-treatment-of-epilepsy-and-excision-of-tumors-and-post-traumatic-epileptogenic-lesions-in-kinshasa-rdc
#12
G Ntsambi-Eba, A Beltchika Kalubye, J P Kalala Okito
Surgery is a treatment to consider in epilepsy when the condition is refractory or epileptic events are related to a clearly identified brain abnormality. The tropical climate of the DRC explains the high risk of epilepsy and the potentially large number of refractory cases. The number of patients with epilepsy in Kinshasa is estimated to be at least 120 000, and almost one third may be refractory. Hence, the need to integrate the use of surgery in the treatment of this disease. Most neurosurgical techniques used for treating epilepsy are practiced with a neurosurgical microscope and neuronavigation...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29290532/thrombolysis-alert-in-hassan-ii-university-teaching-hospital-of-fez-morocco-a-prospective-study-of-2-years
#13
Moussa Toudou Daouda, Siham Bouchal, Naima Chtaou, Aouatef Midaoui, Zouahyr Souirti, Faouzi Belahsen
BACKGROUND: Thrombolysis alert (TA) is a procedure triggered every time a patient consults for sudden focal neurological deficit within 4.5 hours. OBJECTIVE: We aimed to determine firstly the etiological profile of TA and secondly to evaluate the delays in the management not only of thrombolyzed patients but also of nonthrombolyzed patients to determine the intrahospital delays to optimize. METHODS: Patients aged over 18 years who consulted for sudden focal neurological deficit within 4...
December 29, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29288860/association-between-idh1-2-mutation-and-preoperative-seizures-in-patients-with-low-grade-versus-high-grade-glioma-a-systematic-review-and-meta-analysis
#14
Kevin Phan, Wyatt Ng, Victor M Lu, Kerrie L McDonald, Jacob Fairhall, Rajesh Reddy, Peter Wilson
BACKGROUND: Seizures are a common presentation of brain tumors particularly in gliomas. Higher incidences of seizure have been reported in low-grade glioma and tumors located within the temporal and insular area. The association between IDH1/2 mutations with preoperative seizures in glioma and the magnitude of this association in low versus high-grade gliomas remains unclear. To clarify this relationship, a systematic review and meta-analysis was performed. METHOD: Following the PRISMA guidelines and systematic review recommendations, electronic searches were performed on varies journal database and included literature up to May 2017...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29279795/primary-intracranial-leiomyosarcoma-presenting-with-massive-peritumoral-edema-and-mass-effect-case-report-and-literature-review
#15
Sachidanand Gautam, Rajesh K Meena
Background: Primary intracranial leiomyosarcomas (LMSs) are unusual tumors of the central nervous system (CNS) affecting all age groups, and are recently, becoming more prevalent in immunosuppressive conditions such as in patients with human immunodeficiency virus (HIV) infection. However, only a few CNS LMS case reports exist in the English literature, on the occurrence of this rare entity in immunocompetent adults. Even, rarer is a purely intraparenchymal occurrence without any dural attachment in afflicted individuals...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29250844/intractable-epilepsy-due-to-a-rosette-forming-glioneuronal-tumor-with-a-dysembryoplastic-neuroepithelial-background
#16
Noriko Sumitomo, Akihiko Ishiyama, Makoto Shibuya, Eiji Nakagawa, Yu Kaneko, Akio Takahashi, Taisuke Otsuki, Akiyoshi Kakita, Yuko Saito, Noriko Sato, Kenji Sugai, Masayuki Sasaki
A rosette-forming glioneuronal tumor (RGNT) was initially reported as an infratentorial tumor that comprised both small neurocytic rosettes and astrocytic components. However, a few studies have reported supratentorial RGNTs arising in the cerebral hemispheres. Here, we report an unusual case involving a 9-year-old boy with a supratentorial RGNT who presented with intractable epilepsy and behavioral changes. Brain MRI revealed a well-circumscribed space-occupying lesion with septae in the right inferomedial parietal lobe...
December 18, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29250697/two-girl-patients-with-medulloblastoma-case-reports
#17
Laura Daniela Marinău, Cristina Elena Singer, Cristian Meşină, Elena Carmen Niculescu, Ileana Puiu, Ileana Octavia Petrescu, Cristiana Geormăneanu, Augustina Cornelia Enculescu, Daniela Elise Tache, Ştefana Oana Purcaru, Simona Răciulă, Cosmina Lucia Damian
In childhood, the most common type of brain tumors is medulloblastoma, a highly malignant primary brain tumor that is found in the cerebellum or posterior fossa. The tumor mass increases and generates obstructive hydrocephalus. Risk factors (that might be involved in some cases) include the genetic syndrome such as type 1 neurofibromatosis, exposure to ionizing radiation and Epstein-Barr virus. Medulloblastoma is associated with recessively inherited Turcot disease and with conditions as ataxia-telangiectasia syndrome in several cases...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29248175/calvarium-mass-as-the-first-presentation-of-glioblastoma-multiforme-a-very-rare-manifestation-of-high-grade-glioma
#18
S Taghipour Zahir, M Mortaz, M Baghi Yazdi, N Sefidrokh Sharahjin, M Shabani
Glioblastoma multiforme (GBM) is a high grade glial tumor, primarily located in cerebral hemispheres. The most common clinical presentations are slowly progressive neurological deficit such as motor weakness, seizure, and headaches that last less than three months. Calvarium and extra-axial invasion are very rare and generally occur after a brain biopsy or surgery, or secondary to radiotherapy of primary intra-axial glial tumors. We report a case of GBM with calvarium involvement in a 60-year-old man who presented with a frontal bump and left-sided clumsiness...
December 13, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29221145/subependymal-giant-cell-astrocytomas-in-tuberous-sclerosis-complex-have-consistent-tsc1-tsc2-biallelic-inactivation-and-no-braf-mutations
#19
Anika Bongaarts, Krinio Giannikou, Roy J Reinten, Jasper J Anink, James D Mills, Floor E Jansen, G M Wim Spliet, Willfred F A den Dunnen, Roland Coras, Ingmar Blümcke, Werner Paulus, Theresa Scholl, Martha Feucht, Katarzyna Kotulska, Sergiusz Jozwiak, Anna Maria Buccoliero, Chiara Caporalini, Flavio Giordano, Lorenzo Genitori, Figen Söylemezoğlu, José Pimentel, Mark Nellist, Antoinette Y N Schouten-van Meeteren, Anwesha Nag, Angelika Mühlebner, David J Kwiatkowski, Eleonora Aronica
Subependymal giant cell astrocytomas (SEGAs) are rare, low-grade glioneuronal brain tumors that occur almost exclusively in patients with tuberous sclerosis complex (TSC). Though histologically benign, SEGAs can lead to serious neurological complications, including hydrocephalus, intractable seizures and death. Previous studies in a limited number of SEGAs have provided evidence for a biallelic two-hit inactivation of either TSC1 or TSC2, resulting in constitutive activation of the mechanistic target of rapamycin complex 1 pathway...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29217981/mutating-our-understanding-of-brain-tumors-and-seizures-entrez-idh
#20
COMMENT
Jong Woo Lee
No abstract text is available yet for this article.
November 2017: Epilepsy Currents
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