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https://www.readbyqxmd.com/read/29906628/sleep-disorders-in-children-with-incidental-pineal-cyst-on-mri-a-pilot-study
#1
Lourdes M DelRosso, Kenneth Martin, Oliviero Bruni, Raffaele Ferri
INTRODUCTION: For several years, pineal cysts have been considered an incidental finding on brain MRI's even though research and case reports have shown a possible association of pineal cysts with headaches and sleep disturbances. This pilot study aims to evaluate sleep disorders in school-age children with an incidental pineal cyst in an otherwise normal brain MRI. METHOD: Children aged 6-12 years, who were referred for evaluation of headaches, tics, or syncope, and had an incidental pineal cyst on an otherwise normal brain MRI were included and compared to a control group of children with the same referral reasons but with a normal MRI and to a cohort of normal controls...
May 16, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29905512/cranioplasty-with-a-low-cost-customized-polymethylmethacrylate-implant-using-a-desktop-3d-printer
#2
Jesús A Morales-Gómez, Everardo Garcia-Estrada, Jorge E Leos-Bortoni, Miriam Delgado-Brito, Luis E Flores-Huerta, Adriana A De La Cruz-Arriaga, Luis J Torres-Díaz, Ángel R Martínez-Ponce de León
OBJECTIVE Cranioplasty implants should be widely available, low in cost, and customized or easy to mold during surgery. Although autologous bone remains the first choice for repair, it cannot always be used due to infection, fragmentation, bone resorption, or other causes, which led to use of synthetic alternatives. The most frequently used allogenic material for cranial reconstructions with long-term results is polymethylmethacrylate (PMMA). Three-dimensional printing technology has allowed the production of increasingly popular customized, prefabricated implants...
June 15, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29883923/cerebral-amyloid-angiopathy-related-inflammation-with-epilepsy-mimicking-a-presentation-of-brain-tumor-a-case-report-and-review-of-the-literature
#3
Kosuke Kusakabe, Akihiro Inoue, Shirabe Matsumoto, Mie Kurata, Riko Kitazawa, Hideaki Watanabe, Takeharu Kunieda
INTRODUCTION: Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare and treatable variant of cerebral amyloid angiopathy, lacks specific imaging and clinical features, and requires invasive brain biopsy to confirm the diagnosis. We report the case of a patient with nonconvulsive status epilepticus (NCSE) caused by CAA-ri in the right occipital lobe. PRESENTATION OF CASE: A 78-year-old man with a history of hypertension and rheumatoid arthritis was admitted to our hospital following an episode of seizures...
May 29, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29878277/left-transsylvian-transcisternal-and-transinferior-insular-sulcus-approach-for-resection-of-uncohippocampal-tumor-3-dimensional-operative-video
#4
Juan C Fernandez-Miranda
The medial temporal lobe can be divided in anterior, middle, and posterior segments. The anterior segment is formed by the uncus and hippocampal head, and it has extra and intraventricular structures. There are 2 main approaches to the uncohippocampal region, the anteromedial temporal lobectomy (Spencer's technique) and the transsylvian selective amygdalohippocampectomy (Yasargil's technique).In this video, we present the case of a 29-yr-old man with new onset of generalized seizures and a contrast-enhancing lesion in the left anterior segment of the medial temporal lobe compatible with high-grade glioma...
June 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29875203/acute-and-chronic-neurological-consequences-of-early-life-zika-virus-infection-in-mice
#5
Isis Nem de Oliveira Souza, Paula S Frost, Julia V França, Jéssica B Nascimento-Viana, Rômulo L S Neris, Leandro Freitas, Daniel J L L Pinheiro, Clara O Nogueira, Gilda Neves, Leila Chimelli, Fernanda G De Felice, Ésper A Cavalheiro, Sergio T Ferreira, Iranaia Assunção-Miranda, Claudia P Figueiredo, Andrea T Da Poian, Julia R Clarke
Although congenital Zika virus (ZIKV) exposure has been associated with microcephaly and other neurodevelopmental disorders, long-term consequences of perinatal infection are largely unknown. We evaluated short- and long-term neuropathological and behavioral consequences of neonatal ZIKV infection in mice. ZIKV showed brain tropism, causing postnatal-onset microcephaly and several behavioral deficits in adulthood. During the acute phase of infection, mice developed frequent seizures, which were reduced by tumor necrosis factor-α (TNF-α) inhibition...
June 6, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29869040/choice-of-antiepileptic-drugs-affects-the-outcome-in-cancer-patients-with-seizures
#6
B Cacho-Diaz, D San-Juan, K Salmeron, C Boyzo, N Lorenzana-Mendoza
BACKGROUND: Seizures in cancer patients may occur as a result of CNS primary or metastatic tumor, brain surgery, vascular disease, pharmacologic treatment (including chemotherapy), radiation therapy, or metabolic disorders. The aims of the study were to a) determine whether seizures in cancer patients have prognostic implications and b) study patient outcome based on the antiepileptic drug used. METHOD: This is a prospective comparative study that included adult cancer patients with and without seizures from May 2010 to November 2016 seen by the neuro-oncology unit at a cancer referral center...
June 4, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29858515/comorbid-epilepsy-in-autism-spectrum-disorder-implications-of-postnatal-inflammation-for-brain-excitability
#7
Megan Leigh Lewis, Mitchell Kesler, Sydney A Candy, Jong M Rho, Quentin J Pittman
OBJECTIVE: In different cohorts, 5%-30% of individuals with autism spectrum disorder (ASD) also have epilepsy. The high co-occurrence of these disorders suggests that a common mechanistic link may exist. The underlying pathophysiology of this comorbidity remains unknown. To investigate the mechanism(s) involved in the pathogenesis of ASD and epilepsy, we developed and validated a novel mouse model that concurrently exhibits hallmark features of both disorders. METHODS: We utilized inbred BTBR T+ Itpr3tf/J (BTBR) mice that exhibit the core behavioral characteristics of ASD (ie, impaired sociability, altered vocalizations, and restricted interests)...
June 2, 2018: Epilepsia
https://www.readbyqxmd.com/read/29797181/tumor-related-epilepsy-epidemiology-pathogenesis-and-management
#8
REVIEW
Dillon Y Chen, Clark C Chen, John R Crawford, Sonya G Wang
INTRODUCTION: Seizure is a common comorbidity in patients with brain tumor. It may be the presenting symptom or develop after the tumor diagnosis. The underlying pathophysiology of brain tumor-related epilepsy remains poorly understood. METHODS: A comprehensive literature review of Pubmed English articles from 1980-2017 was performed to summarize current knowledge and treatment options of brain tumor-related epilepsy. RESULTS: Multiple factors have been found to contribute to tumor-related epilepsy, including tumor type, speed of tumor growth, location, and tumor burden...
May 24, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29793313/therapeutic-effects-of-scoparone-on-pilocarpine-pilo-induced-seizures-in-mice
#9
Jie Xia, Cheng-Yan Li, Hui Wang, Qi-Mei Zhang, Zhong-Mou Han
Epilepsy is a common and devastating neurological disorder. Inflammatory processes and apoptosis in brain tissue have been reported in human epilepsy. Scoparone (6,7-dimethoxycoumarin) is an important chemical substance, which has multiple beneficial activities, including antitumor, anti-inflammatory and anti-coagulant properties. In our present study, we attempted to investigate if scoparone could attenuate seizures-induced blood brain barrier breakdown, inflammation and apoptosis. Pilocarpine (Pilo) and methylscopolamine were used to establish acute seizure animal model...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29790469/intraventricular-ganglioglioma-presenting-with-spontaneous-hemorrhage
#10
Alexandre Rainha Campos, Luisa Biscoito, Maria Gabriela Gasparinho
Intraventricular gangliogliomas presenting with spontaneous hemorrhage are rare. Due to high density of important tracts lateral to the ventricular atrium, the intraparietal trans sulcal approach is a good option to remove lesions in this location. These tracts are displaced and sometimes destroyed by the presence of large masses. A 33-year-old male presented with a sudden headache and a generalized seizure. He had a left visual field hemianopia and left visual field neglect. Brain computer tomography and magnetic resonance imaging revealed a hemorrhagic tumor located in his right atrium...
March 29, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29789464/role-of-mtor-complexes-in-neurogenesis
#11
REVIEW
Francesca LiCausi, Nathaniel W Hartman
Dysregulation of neural stem cells (NSCs) is associated with several neurodevelopmental disorders, including epilepsy and autism spectrum disorder. The mammalian target of rapamycin (mTOR) integrates the intracellular signals to control cell growth, nutrient metabolism, and protein translation. mTOR regulates many functions in the development of the brain, such as proliferation, differentiation, migration, and dendrite formation. In addition, mTOR is important in synaptic formation and plasticity. Abnormalities in mTOR activity is linked with severe deficits in nervous system development, including tumors, autism, and seizures...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29789203/papillary-glioneuronal-tumor-a-case-report
#12
Julián Castro Castro, Olalla Lista Martínez, Nuria Caramés Díaz, Noemi Conde Lorenzo
Papillary glioneuronal tumor (PGNT) is a recently described central nervous system neoplasm. In 2007, the World Health Organization classified this tumor as a grade I neuronal-glial neoplasm. Patients are usually juvenile and young adults who commonly present with headache or seizures. We report a case of a 13-year-old boy that was related to our hospital after suffering a mild head injury result of an automobile accident. Emergent CT scan showed a right hypointense temporo-occipital lesion. MRI confirmed the presence of a lesion suggestive of a primary brain tumor...
May 19, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29782307/cutaneous-manifestations-of-tuberous-sclerosis
#13
Mirjana Bakić, Marina Ratković, Branka Gledović, Balsa Vujović, Danilo Radunović, Vera Babić, Vladimir Prelević
Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). There are two different genetic loci responsible for TS: 9q34 (TSC1-hamartin) and 16p13...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29775768/canine-pet-dog-tumor-microsurgery-and-intratumoral-concentration-and-safety-of-metronomic-chlorambucil-for-spontaneous-glioma-a-phase-i-clinical-trial
#14
R Timothy Bentley, Stephanie A Thomovsky, Margaret A Miller, Deborah W Knapp, Aaron A Cohen-Gadol
INTRODUCTION: Metronomic (daily low-dose) chlorambucil requires further study before implementation in human glioma. OBJECTIVE: Investigate the distribution and safety of metronomic chlorambucil in naturally occurring canine glioma. METHODS: Eight client-owned (pet) dogs with newly diagnosed spontaneous glioma were prospectively enrolled. Chlorambucil was administered preoperatively at 4 mg/m2 q 24hr for ≥ 3 days, and continued postoperatively until death or dose-limiting adverse events...
May 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29774868/-seizure-susceptible-brain-regions-in-patients-with-low-grade-gliomas
#15
Yinyan Wang, Tao Jiang
Patients afflicted with low-grade glioma frequently suffer from seizures. The mechanisms for seizure initiation in these patients remain poorly understood. Tumor location is correlated with seizure initiation. However, these correlative studies rely on dichotomized data analysis which is based on arbitrary lobe assignments. As a result, the lesion-symptom correlation may be incorrectly interpreted. Categorizing patients according to tumor involvement in a single brain lobe might cause the neglect of important information, such as lesion location and lesion volume...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29774497/safety-of-commercial-airflight-in-patients-with-brain-tumors-a-case-series
#16
Michelle Phillips, Marlon Saria, Amy Eisenberg, Daniel F Kelly, Garni Barkhoudarian
INTRODUCTION: Patients with intracranial masses are often advised to avoid airflight due to concerns of worsening neurological symptoms or deterioration. However, many patients often travel cross-country or internationally to tertiary care centers for definitive care. This study assesses the safety of commercial airflight for brain and skull base tumor patients without severe or progressive neurological deficits. METHODS: Patients that had traveled to our institution for surgery via commercial airflight from 2014 to 2017 were identified...
May 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29773433/-cerebral-and-pulmonary-nocardiosis-to-nocardia-abscessus-in-an-immunocompetent-algerian-patient
#17
D Arrache, H Zait, V Rodriguez-Nava, E Bergeron, T Durand, M Yahiaoui, F Grenouillet, A Amrane, F Chaouche, A Baiod, K Madani, B Hamrioui
Nocardial brain abscess is often occurring in immunocompromised patients. It is uncommon in immunocompetent individuals. Here, the authors describe a case of cerebral and pulmonary nocardiosis mimicking a metastatic tumor in an apparently health 40-year-old Algerian male. The patient presented multiple brain abscess revealed by inaugural epileptic seizure. He was afebrile and presented with left hemiparesis. Staging imaging showed a nodular lung lesion in the apical segment of the right lower lobe. The patient underwent double craniotomy for resection of the lesion...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29770251/review-of-the-neurological-benefits-of-phytocannabinoids
#18
REVIEW
Joseph Maroon, Jeff Bost
Background: Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia. The phytocannabinoids, cannabidiol (CBD), and delta-9-tetrahydrocannabinol (Δ9-THC) are the most studied extracts from cannabis sativa subspecies hemp and marijuana. CBD and Δ9-THC interact uniquely with the endocannabinoid system (ECS). Through direct and indirect actions, intrinsic endocannabinoids and plant-based phytocannabinoids modulate and influence a variety of physiological systems influenced by the ECS...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29739181/accidental-intracerebral-injection-and-seizure-during-scalp-nerve-blocks-for-awake-craniotomy-in-a-previously-craniotomized-patient
#19
Woo Kyung Lee, Hyunzu Kim, Myung-Il Bae, Seung Ho Choi, Kyeong Tae Min
A 34-year-old man who previously underwent a craniotomy due to oligodendroglioma was admitted with a diagnosis of recurrent brain tumor. An awake craniotomy was planned. Approximately 15 minutes after completing the scalp nerve block, his upper torso suddenly moved and trembled for 10 seconds, suggesting a generalized clonic seizure. He recovered gradually and fully in 55 minutes without any neurological sequelae. The emergency computed tomography scan revealed a localized fluid collection and small intracerebral hemorrhage nearby in the temporoparietal cortex beneath the skull defect...
May 9, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29735527/nuclear-pten-deficiency-causes-microcephaly-with-decreased-neuronal-soma-size-and-increased-seizure-susceptibility
#20
Atsushi Igarashi, Kie Itoh, Tatsuya Yamada, Yoshihiro Adachi, Takashi Kato, Hiromi Sesaki, Daisuke Murata, Miho Iijima
Defects in phosphatase and tensin homolog (PTEN) are associated with neurological disorders and tumors. PTEN functions at two primary intracellular locations: the plasma membrane and the nucleus. At the membrane, PTEN functions as a phosphatidylinositol (3,4,5)-trisphosphate phosphatase and suppresses PI3-kinase signaling that drives cell growth and tumorigenesis. However, the in vivo function of nuclear PTEN is unclear. Here, using CRISPR/Cas9, we generated a mouse model in which PTEN levels in the nucleus are decreased...
May 7, 2018: Journal of Biological Chemistry
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