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https://www.readbyqxmd.com/read/28803223/social-responsibilities-of-a-physician-reflections-of-major-general-s-l-bhatia-1891-1981
#1
Radhika Hegde, Mario Vaz
This paper examines various documents written by Major General SL Bhatia CIE, MC, IMS from the 1920s to the1960s on the "Social Responsibilities of a Physician". His reflections are of historical significance, since they provide us with an insight into the challenges confronting the people who attempted to rebuild a nation plagued by poverty resulting from fractured agricultural growth, a feudalistic social structure and the regional inequalities that accompany it, and prolonged imperial rule, among other things...
July 25, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28803008/two-step-large-volume-magnetic-separation-combined-with-pcr-assay-for-sensitive-detection-of-listeria-monocytogenes-in-pasteurized-milk
#2
Dan Luo, Xiaolin Huang, Yan Mao, Chaochao Chen, Fulai Li, Hengyi Xu, Yonghua Xiong
Immunomagnetic separation (IMS) is an effective tool for the preconcentration and purification of food-borne pathogens from complex food samples because of its high capture efficiency (CE). In conventional IMS, antibodies are usually conjugated on the surface of magnetic beads (MB); the random orientation and conformation changes of antibodies on the MB surface can decrease their bioactivity. Moreover, the Brownian motion of immobilized antibodies is weakened, thereby rendering their binding efficiency with bacteria lower than that of free antibodies...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28800312/circulating-endothelial-cells-and-microparticles-for-prediction-of-tumor-progression-and-outcomes-in-advanced-non-small-cell-lung-cancer
#3
Fadi Najjar, Moocheer Alammar, Ghassan Al-Massarani, Nissreen Almalla, Abdulmunim Aljapawe, Adnan Ikhtiar
BACKGROUND: Circulating endothelial cells (CECs) and microparticles (MPs) are proposed as useful biosensors for angiogenesis and membrane damage in cancer. OBJECTIVE: We investigated their predictive value for progression disease (PD) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with cytotoxic chemotherapy. METHODS: Peripheral blood samples were obtained from 60 patients. Immunomagnetic separation (IMS) and flow cytometry techniques were used to quantify CECs and MPs, respectively...
July 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28794799/recommendations-for-action-a-community-meeting-in-preparation-for-a-mass-casualty-opioid-overdose-event-in-southeastern-ontario
#4
Kieran Michael Moore, Nicholas Papadomanolakis-Pakis, Adrienne Hansen-Taugher, Tianxiu H Guan, Brian Schwartz, Paula Stewart, Pamela Leece, Richard Bochenek
Given the steady rise of overdose morbidity and mortality in North America, and increasing frequency of sudden clusters of non-fatal and fatal overdoses in other jurisdictions, regional preparedness plans to respond effectively to clusters of overdoses may reduce the impact of such events on the population. On the 27th of February 2017 in Kingston, Ontario, KFL&A Public Health, in collaboration with public health partners, hosted a full-day workshop involving table-top exercises and discussions for service partners on how to prepare for, respond to, and manage a mass-casualty event secondary to opioid overdose in Southeastern Ontario...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/28793067/farm%C3%A3-cia-popular-program-pharmaceutical-market-analysis-of-antihypertensive-acting-on-the-renin-angiotensin-system-medicines
#5
Rondineli Mendes da Silva, Gabriela Costa Chaves, Luisa Arueira Chaves, Mônica Rodrigues Campos, Vera Lucia Luiza, Andréa Dâmaso Bertoldi, Dennis Ross-Degnan, Isabel Cristina Martins Emmerick
This paper aims to analyse changes in the retail pharmaceutical market following policy changes in the Farmácia Popular Program (FP), a medicines subsidy program in Brazil. The retrospective longitudinal analyses focus on therapeutic class of agents acting on the renin-angiotensin system. Data obtained from QuintilesIMS (formerly IMS Health) included private retail pharmacy sales volume (pharmaceutical units) and sales values from 2002 to 2013. Analyses evaluated changes in market share following key FP policy changes...
August 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28789660/development-and-validation-of-the-medical-student-scholar-ideal-mentor-scale-mss-ims
#6
Stephen M Sozio, Kitty S Chan, Mary Catherine Beach
BACKGROUND: Programs encouraging medical student research such as Scholarly Concentrations (SC) are increasing nationally. However, there are few validated measures of mentoring quality tailored to medical students. We sought to modify and validate a mentoring scale for use in medical student research experiences. METHODS: SC faculty created a scale evaluating how medical students assess mentors in the research setting. A validated graduate student scale of mentorship, the Ideal Mentor Scale, was modified by selecting 10 of the 34 original items most relevant for medical students and adding an item on project ownership...
August 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28783195/murine-cutaneous-leishmaniasis-investigated-by-maldi-mass-spectrometry-imaging
#7
Fernanda Negrão, Daniele F de O Rocha, Caroline F Jaeeger, Francisca J S Rocha, Marcos N Eberlin, Selma Giorgio
Imaging mass spectrometry (IMS) is recognized as a powerful tool to investigate the spatial distribution of untargeted or targeted molecules of a wide variety of samples including tissue sections. Leishmania is a protozoan parasite that causes different clinical manifestations in mammalian hosts. Leishmaniasis is a major public health risk in different continents and represents one of the most important neglected diseases. Cutaneous lesions from mice experimentally infected with Leishmania spp. were investigated by matrix-assisted laser desorption ionization MS using the SCiLS Lab software for statistical analysis...
August 7, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28782433/relational-schemas-as-mediators-of-innovative-moments-in-symptom-improvement-in-major-depression
#8
João Batista, Joana Silva, Sara Freitas, Daniela Alves, Anabela Machado, Inês Sousa, Pablo Fernández-Navarro, Carina Magalhães, Miguel M Gonçalves
OBJECTIVES: Innovative moments (IMs) are exceptions to the maladaptive framework of meaning that typically motivates clients to seek psychotherapy, and previous studies have shown that IMs are associated with psychotherapy outcomes. While IMs are exceptions that occur at the level of the therapeutic conversation, relational schemas are more stable patterns, and their increased flexibility may facilitate change during psychotherapy. With this in mind, we tested the hypothesis that IMs contribute to outcomes by improving the flexibility of relational schemas...
August 5, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28777020/direct-medical-costs-of-treatment-in-newly-diagnosed-high-grade-glioma-among-commercially-insured-us-patients
#9
Shan Jiang, Kala Hill, Dipen Patel, A Reginald Waldeck, Marc Botteman, Abdalla Aly, Andrew D Norden
AIM: This analysis assessed the direct medical costs of newly diagnosed, temozolomide (TMZ)-treated glioblastoma (GBM) from the perspective of a US commercial setting. MATERIALS AND METHODS: The analysis included subjects identified from the IMS PharMetrics LifeLink Plus™ claims database from 01/01/2008 to 08/31/2014 who were ≥18 years of age, had ≥1 malignant brain cancer diagnosis, had brain surgery ≤90 days prior to TMZ initiation, had TMZ treatment, and were continuously enrolled for ≥12 months pre-diagnosis and ≥1 month post-diagnosis...
August 4, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28770415/measurement-accuracy-of-alveolar-soft-tissue-contour-using-a-laboratory-laser-scanner
#10
Daisuke Ueno, Mariko Kobayashi, Kenko Tanaka, Tsuneaki Watanabe, Tetsuro Nakamura, Kazuhiko Ueda, Takatoshi Nagano
Steric analysis of morphological changes is important for evaluation of surgical techniques. This study was performed to assess the measurement accuracy of alveolar soft tissue contour with a laboratory laser scanner. The width of the maxillary alveolar soft tissue contour was evaluated in 20 volunteers. Measurement sites were established in the alveolar soft tissue contour of the maxillary incisor and canine areas. Each site was evaluated by direct measurement with a microcaliper for each subject (DMM) and image measurement using a laboratory laser scanner (IMS)...
August 2, 2017: Odontology
https://www.readbyqxmd.com/read/28763742/the-increased-toxicity-of-uv-degraded-nitroguanidine-and-imx-101-to-zebrafish-larvae-evidence-implicating-oxidative-stress
#11
Kurt A Gust, Jacob K Stanley, Mitchell S Wilbanks, Michael L Mayo, Pornsawan Chappell, Shinita M Jordan, Lee C Moores, Alan J Kennedy, Natalie D Barker
Insensitive munitions (IMs) improve soldier safety by decreasing sympathetic detonation during training and use in theatre. IMs are being increasingly deployed, although the environmental effects of IM constituents such as nitroguanidine (NQ) and IM mixture formulations such as IMX-101 remain largely unknown. In the present study, we investigated the acute (96h) toxicity of NQ and IMX-101 to zebrafish larvae (21d post-fertilization), both in the parent materials and after the materials had been irradiated with environmentally-relevant levels of ultraviolet (UV) light...
September 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28758658/exploring-the-chemistry-of-backbone-amino-chloro-phosphanyl-substituted-imidazole-2-thiones
#12
Abhishek Koner, Spencer C Serin, Gregor Schnakenburg, Brian O Patrick, Derek P Gates, Rainer Streubel
Backbone (R'2N)2P-substituted imidazole-2-thiones 2a-c [(R'2N)2P-IMS(R,R); IMS(R,R) = 1,3-dialkylimidazole-2-thione-4-yl, a: R = (i)Pr, R' = Et; b: R = Mes, R' = Et, c: R = Me, R' = (i)Pr] were treated with PCl3 to synthesize R'2N(Cl)P-substituted imidazole-2-thiones 3a-c [R'2N(Cl)P-IMS(R,R)]. The P-chloro compounds 3a,b were used to explore the chemistry further, i.e. nucleophilic substitution at phosphorus using Ph2CHLi or fluorenyl lithium afforded compounds 4a-c [R'2N(R'')P-IMS(R,R); a: R = (i)Pr, R' = Et, R'' = PH2CH; b: R = Mes, R' = Et, R'' = Flu c: R = (i)Pr, R' = Et, R'' = Flu]...
July 31, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28753730/a-microfluidic-device-for-rapid-screening-of-e-coli-o157-h7-based-on-ifast-and-atp-bioluminescence-assay-for-water-analysis
#13
Bongkot Ngamsom, Alma Truyts, Louis Fourie, Shavon Kumar, Mark D Tarn, Alexander Iles, Klariska Moodley, Kevin J Land, Nicole Pamme
We present a simple microfluidic system for rapid screening of Escherichia coli (E. coli) O157:H7 employing the specificity of immunomagnetic separation (IMS) via immiscible filtration assisted by surface tension (IFAST), and the sensitivity of the subsequent adenosine triphosphate (ATP) assay by the bioluminescence luciferin/luciferase reaction. The developed device was capable of detecting E. coli O157:H7 from 6 colony forming units (CFU) in 1 mL spiked buffer within 20 minutes. In tests with wastewater discharged effluent samples, without pre-concentration, the device could detect 104 seeded CFU per mL; suggesting great potential for point-of-need microbiological water quality monitoring...
July 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28750151/pharmacokinetics-and-safety-of-brexpiprazole-following-multiple-dose-administration-to-japanese-patients-with-schizophrenia
#14
Jun Ishigooka, Shuichi Iwashita, Koushi Higashi, Ei Leen Liew, Yoshihiro Tadori
Brexpiprazole is currently approved in the United States for the treatment of schizophrenia and as adjunctive treatment of major depressive disorder. In Canada, it is approved for the treatment of schizophrenia. This study evaluated the pharmacokinetics (PK) and safety of brexpiprazole in Japanese patients with schizophrenia. This phase 1 study comprised a 14-day multiple-dose administration of brexpiprazole 1, 4, and 6 mg/day (n = 7, 8, and 6, respectively). Plasma concentrations and PK parameters and the influence of CYP2D6 polymorphisms (intermediate metabolizers [IMs] and extensive metabolizers [EMs]) on PK were evaluated...
July 27, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28746793/easi-ims-an-expedite-and-secure-technique-to-screen-for-25i-nboh-in-blotter-papers
#15
Damila Rodrigues de Morais, Ingrid Lopes Barbosa, Kelly Francisco Cunha, Guilherme Lucas Tripodi, Célio Fernando Figueiredo Angolini, Marcos Fernando Franco, Elvis Medeiros de Aquino, Marcos Nogueira Eberlin, Jose Luiz Costa
The increasing number of new psychoactive substances (NPS) and their quick worldwide spreading, often only slightly modified in the form of new derivatives and analogues, have brought the need for fast, wide-ranging and unequivocal identification methods in clinical and forensic investigations. Since it usually provides secure results, gas chromatography coupled to mass spectrometry (GC-MS) has been routinely employed as the standard technique for the detection of NPS in blotter papers. For 25I-NBOH (N-(2-hydroxybenzyl)-2-(4-iodo-2,5-dimethoxyphenyl)ethan-1-aminium), however, GC-MS analysis of an blotter paper extract leads to incorrect results...
July 26, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28745578/cost-effectiveness-of-g5-mobile-continuous-glucose-monitoring-cgm-device-compared-with-self-monitoring-of-blood-glucose-smbg-alone-for-people-with-type-1-diabetes-from-the-canadian-societal-perspective
#16
Shraddha Chaugule, Claudia Graham
AIMS: To evaluate the cost-effectiveness of real-time continuous glucose monitoring (CGM) compared to self-monitoring of blood glucose (SMBG) alone in people with type 1 diabetes (T1DM) using multiple daily injections (MDI) from the Canadian societal perspective. METHODS: The IMS CORE Diabetes Model (v.9.0) was used to assess the long-term (50 years) cost-effectiveness of real-time CGM (G5 Mobile CGM System; Dexcom, Inc., San Diego, CA) compared with SMBG alone for a cohort of adults with poorly-controlled T1DM...
July 26, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28743758/ashp-national-survey-of-pharmacy-practice-in-hospital-settings-prescribing-and-transcribing-2016
#17
Craig A Pedersen, Philip J Schneider, Douglas J Scheckelhoff
PURPOSE: The results of the 2016 ASHP national survey of pharmacy practice in hospital settings are presented. METHODS: A stratified random sample of pharmacy directors at 1,315 general and children's medical-surgical hospitals in the United States were surveyed using a mixed-mode method offering a choice of completing a paper survey or an online survey. IMS Health supplied data on hospital characteristics; the survey sample was drawn from IMS's hospital database...
July 25, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28743318/benefits-of-manometer-in-non-invasive-ventilatory-support
#18
Rodrigo Silva Lacerda, Fernando Cesar Anastácio de Lima, Leonardo Pereira Bastos, Anderson Fardin Vinco, Felipe Britto Azevedo Schneider, Yves Luduvico Coelho, Heitor Gomes Costa Fernandes, João Marcus Ramos Bacalhau, Igor Matheus Simonelli Bermudes, Claudinei Ferreira da Silva, Luiza Paterlini da Silva, Rogério Pezato
Introduction Effective ventilation during cardiopulmonary resuscitation (CPR) is essential to reduce morbidity and mortality rates in cardiac arrest. Hyperventilation during CPR reduces the efficiency of compressions and coronary perfusion. Problem How could ventilation in CPR be optimized? The objective of this study was to evaluate non-invasive ventilator support using different devices. METHODS: The study compares the regularity and intensity of non-invasive ventilation during simulated, conventional CPR and ventilatory support using three distinct ventilation devices: a standard manual resuscitator, with and without airway pressure manometer, and an automatic transport ventilator...
July 26, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28742680/individualized-metabolic-surgery-score-procedure-selection-based-on-diabetes-severity
#19
Ali Aminian, Stacy A Brethauer, Amin Andalib, Amy S Nowacki, Amanda Jimenez, Ricard Corcelles, Zubaidah Nor Hanipah, Suriya Punchai, Deepak L Bhatt, Sangeeta R Kashyap, Bartolome Burguera, Antonio M Lacy, Josep Vidal, Philip R Schauer
OBJECTIVE: To construct and validate a scoring system for evidence-based selection of bariatric and metabolic surgery procedures according to severity of type 2 diabetes (T2DM). BACKGROUND: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) account for >95% of bariatric procedures in United States in patients with T2DM. To date, there is no validated model to guide procedure selection based on long-term glucose control in patients with T2DM. METHODS: A total of 659 patients with T2DM who underwent RYGB and SG at an academic center in the United States and had a minimum 5-year follow-up (2005-2011) were analyzed to generate the model...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742128/construction-and-characterization-of-the-korean-whole-saliva-proteome-to-determine-ethnic-differences-in-human-saliva-proteome
#20
Ha Ra Cho, Han Sol Kim, Jun Seo Park, Seung Cheol Park, Kwang Pyo Kim, Troy D Wood, Yong Seok Choi
As the first step to discover protein disease biomarkers from saliva, global analyses of the saliva proteome have been carried out since the early 2000s, and more than 3,000 proteins have been identified in human saliva. Recently, ethnic differences in the human plasma proteome have been reported, but such corresponding studies on human saliva in this aspect have not been previously reported. Thus, here, in order to determine ethnic differences in the human saliva proteome, a Korean whole saliva (WS) proteome catalogue indexing 480 proteins was built and characterized through nLC-Q-IMS-TOF analyses of WS samples collected from eleven healthy South Korean male adult volunteers for the first time...
2017: PloS One
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