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https://www.readbyqxmd.com/read/29161047/mapping-extracellular-matrix-proteins-in-formalin-fixed-paraffin-embedded-tissues-by-maldi-imaging-mass-spectrometry
#1
Peggi M Angel, Susana Comte-Walters, Lauren E Ball, Kacey Talbot, Anand Mehta, Kelvin G M Brockbank, Richard R Drake
Collagens and elastin form the fundamental framework of all tissues and organs and their expression and post-translational processing are tightly regulated in disease and health. Due to their unique structural composition and properties, it is a recognized challenge to access these protein structures within the complex tissue microenvironment to understand how localized changes modulate tissue health. We describe a new workflow using a combination of matrix-assisted laser desorption /ionization imaging mass spectrometry (MALDI IMS) with collagenase and matrix metalloproteinase (MMP) enzymes to access and report on spatial localization of collagen and elastin sequences in formalin-fixed, paraffin-embedded (FFPE) tissues...
November 21, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29151502/isolated-pancreatic-myeloid-sarcoma-associated-with-t-8-21-runx1-runx1t1-rearrangement
#2
Kenji Tokunaga, Ayako Yamamura, Shikiko Ueno, Yoshitaka Kikukawa, Shunichiro Yamaguchi, Michihiro Hidaka, Naofumi Matsuno, Tatsuya Kawaguchi, Masao Matsuoka, Yutaka Okuno
No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He was treated with high-dose cytarabine followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). This is the first report of pancreatic IMS with t(8;21). Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29147664/reduced-inspiratory-muscle-strength-in-patients-with-type-2-diabetes-mellitus-and-obstructive-sleep-apnoea
#3
Thomas Rehling, Anne Margareta Banghøj, Marie Hvelplund Kristiansen, Lise Tarnow, Stig Molsted
Background: Obstructive sleep apnoea (OSA) is related to type 2 diabetes (T2DM), and it may be associated with reduced inspiratory muscle strength (IMS). The aim of this study was to investigate the IMS in patients with T2DM, with or without OSA. Methods: Patients with T2DM with OSA (n = 33) and without OSA (n = 28) were included. The maximum IMS was tested using the POWERbreathe KH2 device. Reference IMS values were data calculated using an algorithm based on general populations and adjusted for age and gender...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29146423/comprehensive-lipidomic-analysis-of-human-plasma-using-multidimensional-liquid-and-gas-phase-separations-two-dimensional-liquid-chromatography-mass-spectrometry-vs-liquid-chromatography-trapped-ion-mobility-mass-spectrometry
#4
Anna Baglai, Andrea F G Gargano, Jan Jordens, Ynze Mengerink, Maarten Honing, Sjoerd van der Wal, Peter J Schoenmakers
Recent advancements in separation science have resulted in the commercialization of multidimensional separation systems that provide higher peak capacities and, hence, enable a more-detailed characterization of complex mixtures. In particular, two powerful analytical tools are increasingly used by analytical scientists, namely online comprehensive two-dimensional liquid chromatography (LC×LC, having a second-dimension separation in the liquid phase) and liquid chromatography-ion mobility-spectrometry (LC-IMS, second dimension separation in the gas phase)...
November 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29145020/evaluation-of-7-be-and-133-xe-atmospheric-radioactivity-time-series-measured-at-four-ctbto-radionuclide-stations
#5
Stefano Bianchi, Alessandro Longo, Wolfango Plastino, Pavel P Povinec
Time series analysis of (7)Be and (133)Xe atmospheric data and meteorological parameters measured at four CTBTO/IMS radionuclide stations have shown great variability in terms of noise structures, harmonic content, cross-correlation patterns and local Hurst exponent behaviour. This study focused on highlighting and characterising both differences and similarities expected for these radionuclides due to their different physical and chemical characteristics along with their different source terms. Detrended crosscorrelation analysis of different meteorological parameters influencing the residuals time series has shown that for Canadian and American stations the parameters mostly affecting radionuclide concentrations in the air seem to be wind direction and atmospheric pressure...
November 2, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29138251/mitochondrial-inner-membrane-protease-yme1-degrades-outer-membrane-proteins-tom22-and-om45
#6
Xi Wu, Lanlan Li, Hui Jiang
Mitochondria are double-membraned organelles playing essential metabolic and signaling functions. The mitochondrial proteome is under surveillance by two proteolysis systems: the ubiquitin-proteasome system degrades mitochondrial outer-membrane (MOM) proteins, and the AAA proteases maintain the proteostasis of intramitochondrial compartments. We previously identified a Doa1-Cdc48(-Ufd1-Npl4) complex that retrogradely translocates ubiquitinated MOM proteins to the cytoplasm for degradation. In this study, we report the unexpected identification of MOM proteins whose degradation requires the Yme1(-Mgr1-Mgr3)i-AAA protease complex in mitochondrial inner membrane...
November 14, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29137189/microscopic-and-molecular-tracing-of-cryptosporidium-oocysts-identifying-a-possible-reservoir-of-infection-in-red-grouse
#7
David Baines, Michaela Giles, Michael Richardson
Infection by Cryptosporidiumbaileyi causes respiratory cryptosporidiosis in red grouse Lagopuslagopusscotica. First diagnosed in 2010, it has since been detected across half of moors managed for grouse shooting in northern England. We hypothesised that contaminated grouse faeces within communal trays visited by grouse containing grit coated with flubendazole, provided to control Trichostrongylustenuis parasites of grouse, is a reservoir of infection. To establish the basis to this hypothesis, contents of 23 trays from a grouse moor were examined for Cryptosporidium oocysts...
November 13, 2017: Pathogens
https://www.readbyqxmd.com/read/29136835/design-and-construction-of-an-injection-port-for-coupling-stir-bar-sorptive-extraction-with-ion-mobility-spectrometry
#8
Mohammad T Jafari, Mohammad R Rezayat, Mehdi Mossaddegh
An appropriate injection port was designed and constructed for direct analysis of stir-bar sorptive extractions using an ion mobility spectrometry (IMS). The novel design of the port offers great simplicity in use, high sensitivity, and high thermal and mechanical stability. The sol-gel technique was applied to prepare polydimethylsiloxane absorbent on a stir-bar. The parameters affecting extraction efficiency including stirring rate, extraction temperature, extraction time, salt addition and desorption temperature were optimized...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136284/patient-outcomes-of-genetic-counseling-assessing-the-impact-of-different-approaches-to-family-history-collection
#9
C Slomp, E Morris, A Inglis, A Lehman, J Austin
No studies have evaluated whether different modalities for collection of family history data influence patient outcomes of genetic counseling. We retrospectively compared outcomes of genetic counseling between patients whose family history (Fhx) was collected: a) via telephone prior to their appointment (FhxPrior), or b) during the appointment (FhxDuring). We used a psychiatric genetic counseling clinic database, where information about demographics and Fhx timing is recorded and patients complete the Genetic Counseling Outcomes Scale (GCOS, measuring empowerment) and Illness Management Self-Efficacy Scale (IMSES) immediately prior to (T1) and one-month after their appointment (T2)...
November 14, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29134621/replication-of-mini-sentinel-study-assessing-mirabegron-and-cardiovascular-risk-in-non-mini-sentinel-databases
#10
Jason C Simeone, Beth L Nordstrom, Kwame Appenteng, Samuel Huse, Milbhor D'Silva
BACKGROUND: In 2014, the US Food and Drug Administration (FDA) initiated a prospective routine surveillance using the Mini-Sentinel (M-S) program to assess potential signals of acute myocardial infarction (AMI) and stroke with use of mirabegron, indicated for the treatment of overactive bladder (OAB), compared with oxybutynin. PURPOSE: To replicate the FDA M-S analysis of mirabegron using datasets that did not contribute to the M-S program. METHODS: IMS PharMetrics Plus and Truven MarketScan claims data from 2012-2015 were converted to the M-S Common Data Model...
November 13, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29130763/comparative-evaluation-of-a-novel-phage-protein-ligand-assay-and-immunomagnetic-separation-method-to-isolate-the-seven-top-serogroups-of-escherichia-coli-o157-o26-o103-o145-o111-o45-and-o121-in-foods-at-risk
#11
M Bouvier, S D Miszczycha, X Guillarme, C Tadla, L Collinet, D Thevenot Sergentet
The presence of Shiga toxin-producing Escherichia coli (STEC) in food is a major concern for food safety authorities and industries. Methods for detecting these pathogenic bacteria are crucial. Enrichment of foods for STEC identification has been optimized, but selective concentration of bacteria before isolation still needs to be improved. In the present study, we tested the performance of the VIDAS ESPT detection method against that of the immunomagnetic separation (IMS) method. A preenrichment inoculation was performed to provide a realistic scenario of the contamination that occurs in foods, and the methods were then compared...
December 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29126587/dispersive-magnetic-immunoaffinity-extraction-anatoxin-a-determination
#12
Tinh Le, Francesc A Esteve-Turrillas, Sergio Armenta, Miguel de la Guardia, Guillermo Quiñones-Reyes, Antonio Abad-Fuentes, Antonio Abad-Somovilla
Specific monoclonal antibodies were coupled with magnetic Sepharose-based beads and used, for the first time. The methodology was applied to preconcentrate anatoxin-a from water and the later determination by ion mobility spectrometry (IMS). Dispersive magnetic immunoaffinity (d-MagIA) extraction methodology provided a limit of detection of 0.02μgL(-1) and a satisfactory precision with a relative standard deviation lower than 15%. Recoveries were evaluated at 0.5, 1.0 and 5.0μgL(-1) anatoxin-a with quantitative values from 91 to 115%...
November 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29126286/deep-learning-for-tumor-classification-in-imaging-mass-spectrometry
#13
Jens Behrmann, Christian Etmann, Tobias Boskamp, Rita Casadonte, Jörg Kriegsmann, Peter Maass
Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are required to fully process the data. Since mass spectra exhibit certain structural similarities to image data, deep learning may offer a promising strategy for classification of IMS data as it has been successfully applied to image classification. Results: Methodologically, we propose an adapted architecture based on deep convolutional networks to handle the characteristics of mass spectrometry data, as well as a strategy to interpret the learned model in the spectral domain based on a sensitivity analysis...
November 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29122824/ruthenium-106-brachytherapy-for-iris-and-iridociliary-melanomas
#14
Marina Marinkovic, Nanda Horeweg, Mirjam S Laman, Jaco C Bleeker, Martijn Ketelaars, Femke P Peters, Gre P M Luyten, Carien L Creutzberg
BACKGROUND AND PURPOSE: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs). MATERIALS AND METHODS: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). RESULTS: Overall median follow-up was 36 months...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29119981/magnetic-bead-based-peptide-extraction-methodology-for-tissue-imaging
#15
William T Andrews, Susan B Skube, Amanda B Hummon
MALDI-TOF imaging mass spectrometry (IMS) is a common technique used for analyzing tissue samples, as it allows the user to detect multiple different analytes simultaneously. However, the detection and analysis of these analytes may sometimes be hampered due to the presence of contaminants in the tissue microenvironment, which leads to ion suppression. This challenge necessitates the development of an active extraction technique to selectively isolate analytes of interest without compromising their spatial localization within a tissue sample...
November 9, 2017: Analyst
https://www.readbyqxmd.com/read/29117860/erv1-of-arabidopsis-thaliana-can-directly-oxidize-mitochondrial-intermembrane-space-proteins-in-the-absence-of-redox-active-mia40
#16
Valentina Peleh, Flavien Zannini, Sandra Backes, Nicolas Rouhier, Johannes M Herrmann
BACKGROUND: Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 'generates' disulfide bonds that are passed on to the oxidoreductase Mia40, which oxidizes substrate proteins. A different structural organization of plant Erv1 proteins compared to that of animal and fungal orthologs was proposed to explain its inability to complement the corresponding yeast mutant...
November 8, 2017: BMC Biology
https://www.readbyqxmd.com/read/29116167/no-evidence-of-widespread-decline-of-snow-cover-on-the-tibetan-plateau-over-2000-2015
#17
Xiaoyue Wang, Chaoyang Wu, Huanjiong Wang, Alemu Gonsamo, Zhengjia Liu
Understanding the changes in snow cover is essential for biological and hydrological processes in the Tibetan Plateau (TP) and its surrounding areas. However, the changes in snow cover phenology over the TP have not been well documented. Using Moderate Resolution Imaging Spectroradiometer (MODIS) daily snow products and the Interactive Multi-sensor Snow and Ice Mapping System (IMS) data, we reported daily cloud-free snow cover product over the Tibetan Plateau (TP) for 2000-2015. Snow cover start (SCS), melt (SCM) and duration (SCD) dates were calculated for each hydrological year, and their spatial and temporal variations were analyzed with elevation variations...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29111330/imaging-mass-spectroscopy-delineates-the-thinned-and-thickened-walls-of-intracranial-aneurysms
#18
Taichi Ikedo, Manabu Minami, Hiroharu Kataoka, Kosuke Hayashi, Manabu Nagata, Risako Fujikawa, Fumiyoshi Yamazaki, Mitsutoshi Setou, Masayuki Yokode, Susumu Miyamoto
OBJECT: The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular diseases. To investigate the feature of phospholipid composition of IA walls, we conducted IMS in a rat model of experimentally induced IA. MATERIAL AND METHODS: IAs were surgically induced in 7-week-old male rats and analyzed by IMS in negative-ion mode...
October 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29111149/systematic-approaches-for-biodiagnostics-using-exhaled-air
#19
REVIEW
Pravin Shende, Jai Vaidya, Yogesh A Kulkarni, R S Gaud
The 21st century is witnessing a revolution in understanding the composition of human exhaled breath more deeply, as the "breathe-print" can provide significant information of various diseases and disorders. This review elucidates various breath analytical techniques applied in medical diagnosis. A quick, portable, simple, accurate, non-invasive and relatively inexpensive approach of this technique is the reason of its evolution as a new frontier in disease diagnosis. This review emphasizes on breath biomarkers and traditional approaches in techniques used for breath biosensors like GC-MS, SIFT-MS, PTR-MS, IMS, Optical Absorption, Sensor Arrays and Electronic noses along with other new approaches such as Enzyme Immunoassay, Fluorescent Bead Immunoassays, Polymerase Chain Reaction, Antibody Microarray...
October 27, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29110651/variability-in-market-uptake-of-psychotropic-medications-in-europe-reflects-cultural-diversity
#20
J M Hoebert, A K Mantel-Teeuwisse, H G M Leufkens, L van Dijk
BACKGROUND: In the last 20-30 years, many international studies have found substantial differences in the use of (older) psychotropic medication between European countries. The majority mentioned an important role for attitudes and beliefs towards psychotropic medication. So far, no studies have looked into the effects of cultural diversity on the use of new medications entering the market. As national cultures relate deeply to held values regarding, for example, what is seen as effective versus ineffective or safe versus dangerous, (cultural) diversity in decision making around the role of new medications in clinical practice may already be expected from the first day after market authorization...
November 6, 2017: BMC Health Services Research
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