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https://www.readbyqxmd.com/read/28211480/visualisation-of-abscisic-acid-and-12-oxo-phytodienoic-acid-in-immature-phaseolus-vulgaris-l-seeds-using-desorption-electrospray-ionisation-imaging-mass-spectrometry
#1
Hirofumi Enomoto, Takuya Sensu, Kei Sato, Futoshi Sato, Thanai Paxton, Emi Yumoto, Koji Miyamoto, Masashi Asahina, Takao Yokota, Hisakazu Yamane
The plant hormone abscisic acid (ABA) and the jasmonic acid related-compound 12-oxo-phytodienoic acid (OPDA) play crucial roles in seed development, dormancy, and germination. However, a lack of suitable techniques for visualising plant hormones has restricted the investigation of their biological mechanisms. In the present study, desorption electrospray ionisation-imaging mass spectrometry (DESI-IMS), a powerful tool for visualising metabolites in biological tissues, was used to visualise ABA and OPDA in immature Phaseolus vulgaris L...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194738/collidoscope-an-improved-tool-for-computing-collisional-cross-sections-with-the-trajectory-method
#2
Simon A Ewing, Micah T Donor, Jesse W Wilson, James S Prell
Ion mobility-mass spectrometry (IM-MS) can be a powerful tool for determining structural information about ions in the gas phase, from small covalent analytes to large, native-like or denatured proteins and complexes. For large biomolecular ions, which may have a wide variety of possible gas-phase conformations and multiple charge sites, quantitative, physically explicit modeling of collisional cross sections (CCSs) for comparison to IMS data can be challenging and time-consuming. We present a "trajectory method" (TM) based CCS calculator, named "Collidoscope," which utilizes parallel processing and optimized trajectory sampling, and implements both He and N2 as collision gas options...
February 13, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28194156/integrated-management-strategies-increase-cottonseed-oil-and-protein-production-the-key-role-of-carbohydrate-metabolism
#3
Hongkun Yang, Xinyue Zhang, Binglin Chen, Yali Meng, Youhua Wang, Wenqing Zhao, Zhiguo Zhou
Cottonseed, oil, and protein, as the by-products of cotton production, have the potential to provide commodities to meet the increasing demand of renewable bio-fuels and ruminant feed. An increase in crop yield per unit area requires high-yielding cultivar management with an economic nitrogen (N) rate, an optimal N application schedule, high-yielding plant populations and strong seedlings. Whether the integration of these agronomic practices into a coherent management system can increase the productivity of cotton fiber, embryo oil and protein requires experimental elucidation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28193037/monitoring-isomerization-of-molecules-in-solution-using-ion-mobility-mass-spectrometry
#4
James N Bull, Michael S Scholz, Neville J A Coughlan, Akio Kawai, Evan J Bieske
An ion mobility spectrometer (IMS) with an electrospray ion source is used to investigate photo and thermal isomerization of photoactive molecules in the electrospray syringe. A light emitting diode adjacent to the syringe establishes a photostationary state that relaxes thermally toward the more stable isomer once illumination ceases. The arrangement is demonstrated by measuring Z-E thermal isomerization rates for several azoheteroarene compounds. The IMS technique has a distinct advantage over UV-vis spectrophotometry for measuring isomer populations in situations where there are multiple isomers with overlapping absorption profiles...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28193022/development-of-an-ion-mobility-spectrometry-orbitrap-mass-spectrometer-platform
#5
Yehia M Ibrahim, Sandilya V B Garimella, Spencer A Prost, Roza Wojcik, Randolph V Norheim, Erin S Baker, Ivan Rusyn, Richard D Smith
Complex samples benefit from multidimensional measurements where higher resolution enables more complete characterization of biological and environmental systems. To address this challenge, we developed a drift tube-based ion mobility spectrometry-Orbitrap mass spectrometer (IMS-Orbitrap MS) platform. To circumvent the time scale disparity between the fast IMS separation and the much slower Orbitrap MS acquisition, we utilized a dual gate and pseudorandom sequences to multiplex the injection of ions and allow operation in signal averaging (SA), single multiplexing (SM), and double multiplexing (DM) IMS modes to optimize the signal-to-noise ratio of the measurements...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28191810/gist-institutional-experience-at-srms-ims-india
#6
Shubhanshu Gupta, Keshri Amit, Ashish Gupta, Tanu Argawal
Gastro-Intestinal Stromal Tumors (GIST) is a malignant, non-epithelial, mesenchymal tumor of the digestive tract that is not uncommon in clinical practice nowadays; diagnosis being based upon immuno-histo-chemical analysis of the resected or biopsied (FNAC) specimen. Abdominal lump with or without intra-luminal bleed is a common mode of presentation. Early diagnosis and appropriate management with surgery and/or Imatinib therapy improves recurrence free survival and may impact overall survival. We present here our institutional experience of four patients, admitted in Onco-Surgery Dept...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28183315/pyruvate-kinase-m2-and-the-mitochondrial-atpase-inhibitory-factor-1-provide-novel-biomarkers-of-dermatomyositis-a-metabolic-link-to-oncogenesis
#7
Fulvio Santacatterina, María Sánchez-Aragó, Marc Catalán-García, Glòria Garrabou, Cristina Nuñez de Arenas, Josep M Grau, Francesc Cardellach, José M Cuezva
BACKGROUND: Metabolic alterations play a role in the development of inflammatory myopathies (IMs). Herein, we have investigated through a multiplex assay whether proteins of energy metabolism could provide biomarkers of IMs. METHODS: A cohort of thirty-two muscle biopsies and forty plasma samples comprising polymyositis (PM), dermatomyositis (DM) and sporadic inclusion body myositis (sIBM) and control donors was interrogated with monoclonal antibodies against proteins of energy metabolism using reverse phase protein microarrays (RPPA)...
February 10, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28156253/severe-carotid-stenosis-and-delay-of-reperfusion-in-endovascular-stroke-treatment-an-interventional-management-of-stroke-iii-study
#8
Steven L Gogela, Yair M Gozal, Bin Zhang, Thomas A Tomsick, Andrew J Ringer, Joseph P Broderick, Pooja Khatri, Todd A Abruzzo
OBJECTIVE The impact of extracranial carotid stenosis on interventional revascularization of acute anterior circulation stroke is unknown. The authors examined the effects of high-grade carotid stenosis on the results of endovascular treatment of patients in the Interventional Management of Stroke (IMS)-III trial. METHODS The 278 patients in the endovascular arm of the IMS-III trial were categorized according to the degree of carotid stenosis as determined by angiography. In comparing patients with severe stenosis or occlusion (≥ 70%) to those without severe stenosis (< 70%), the authors evaluated the time to endovascular reperfusion, modified Thrombolysis in Cerebrovascular Infarction (mTICI) scores, 24-hour mean infarct volumes, symptomatic intracerebral hemorrhage rates, and modified Rankin Scale (mRS) scores at 90 days...
February 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28156110/architecture-mapping-of-the-inner-mitochondrial-membrane-proteome-by-chemical-tools-in-live-cells
#9
Song-Yi Lee, Myeong-Gyun Kang, Sanghee Shin, Chulhwan Kwak, Taejoon Kwon, Jeong Kon Seo, Jong-Seo Kim, Hyun-Woo Rhee
The inner mitochondrial membrane (IMM) proteome plays a central role in maintaining mitochondrial physiology and cellular metabolism. Various important biochemical reactions such as oxidative phosphorylation, metabolite production, and mitochondrial biogenesis are conducted by the IMM proteome and mitochondria-targeted therapeutics have been developed for IMM proteins which is deeply related for various human metabolic disease including cancer and neurodegenerative diseases. However, the membrane topology of the IMM proteome remains largely unclear because of the lack of methods to evaluate it in live cells in a high-throughput manner...
February 3, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28131071/early-drug-use-of-dapagliflozin-prescribed-by-general-practitioners-and-diabetologists-in-germany
#10
Matthew Hankins, Katherine Tsai, Joseph Kim, Niklas Hammar
OBJECTIVES: Dapagliflozin is an inhibitor of the human sodium-glucose co-transporter 2 (SGLT2) that has been shown to improve glycaemic control in patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the characteristics and treatment patterns of dapagliflozin users in comparison to users of other anti-diabetic (AD) treatments in Germany. METHODS: Data from patients with T2DM initiating at least one prescription for dapagliflozin or other AD therapy between November 2012 and April 2014 were collected from the IMS German Disease Analyzer database...
November 9, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28124820/evaluation-of-the-long-term-cost-effectiveness-of-liraglutide-versus-lixisenatide-for-treatment-of-type-2-diabetes-mellitus-in-the-uk-setting
#11
B Hunt, G Vega-Hernandez, W J Valentine, N Kragh
AIMS: Glucagon-like peptide-1 (GLP-1) receptor agonists represent an attractive treatment option for patients with type 2 diabetes mellitus as they are associated with improved glycemic control, weight loss and low risk of hypoglycemia. The present analysis aimed to compare the cost-effectiveness of two GLP-1 receptor agonists, liraglutide 1.8 mg and lixisenatide 20 µg, in the UK setting based on the LIRA-LIXI(TM) trial (NCT01973231). MATERIALS AND METHODS: Projections of costs (in 2015 pound sterling [GBP]) and clinical outcomes were made over patient lifetimes using the IMS CORE Diabetes Model...
January 26, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28124761/laboratory-and-clinical-reliability-of-conformally-coated-subretinal-implants
#12
Renate Daschner, Udo Greppmaier, Martin Kokelmann, Sandra Rudorf, Ralf Rudorf, Sebastian Schleehauf, Walter G Wrobel
Despite recent developments and new treatments in ophthalmology there is nothing available to cure retinal degenerations like Retinitis Pigmentosa (RP) yet. One of the most advanced approaches to treat people that have gone blind due to RP is to replace the function of the degenerated photoreceptors by a microelectronic neuroprosthetic device. Basically, this subretinal active implant transforms the incoming light into electric pulses to stimulate the remaining cells of the retina. The functional time of such devices is a crucial aspect...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28121547/oncology-pharma-costs-to-exceed-150-billion-by-2020
#13
(no author information available yet)
Worldwide costs of oncology drugs will rise above $150 billion by 2020, according to a report by the IMS Institute for Healthcare Informatics. Many factors are in play, according to IMS, including the new wave of expensive immunotherapies. Pembrolizumab (Keytruda), priced at $150,000 per year per patient, and nivolumab (Opdivo), priced at $165,000, may be harbingers of the market for cancer immunotherapies.
October 2016: Managed Care
https://www.readbyqxmd.com/read/28117928/maldi-imaging-mass-spectrometry-reveals-multiple-clinically-relevant-masses-in-colorectal-cancer-using-large-scale-tissue-microarrays
#14
Andrea Hinsch, Malte Buchholz, Sinje Odinga, Carina Borkowski, Christina Koop, Jacob R Izbicki, Marcus Wurlitzer, Till Krech, Waldemar Wilczak, Stefan Steurer, Frank Jacobsen, Eike-Christian Burandt, Phillip Stahl, Ronald Simon, Guido Sauter, Hartmut Schlüter
For identification of clinically relevant masses to predict status, grade, relapse and prognosis of colorectal cancer we applied MALDI imaging mass spectrometry (IMS) to a tissue micro array (TMA) containing formalin-fixed and paraffin-embedded tissue samples from 349 patients. Analysis of our MALDI-IMS data revealed 27 different m/z signals associated with epithelial structures. Comparison of these signals showed significant association with status, grade and Ki-67 labeling index. 15 out of 27 IMS signals revealed a significant association with survival...
January 24, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28117473/perme-intensive-care-unit-mobility-score-and-icu-mobility-scale-translation-into-portuguese-and-cross-cultural-adaptation-for-use-in-brazil
#15
Yurika Maria Fogaça Kawaguchi, Ricardo Kenji Nawa, Thais Borgheti Figueiredo, Lourdes Martins, Ruy Camargo Pires-Neto
Objective: To translate the Perme Intensive Care Unit Mobility Score and the ICU Mobility Scale (IMS) into Portuguese, creating versions that are cross-culturally adapted for use in Brazil, and to determine the interobserver agreement and reliability for both versions. Methods: The processes of translation and cross-cultural validation consisted in the following: preparation, translation, reconciliation, synthesis, back-translation, review, approval, and pre-test...
November 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28115831/an-evaluation-of-adherence-in-patients-with-multiple-sclerosis-newly-initiating-treatment-with-a-self-injectable-or-an-oral-disease-modifying-drug
#16
Michael Munsell, Molly Frean, Joseph Menzin, Amy L Phillips
OBJECTIVE: As the multiple sclerosis (MS) disease-modifying drug (DMD) treatment options have expanded to include oral therapies, it is important to understand whether route of administration is associated with DMD adherence. The objective of this study was to compare adherence to DMDs in patients with MS newly initiating treatment with a self-injectable versus an oral DMD. METHODS: This retrospective database study used IMS Health Real World Data Adjudicated Claims - US data between July 1, 2010 and June 30, 2014...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28110657/maldi-mass-spectrometry-imaging-of-n-linked-glycans-in-cancer-tissues
#17
R R Drake, T W Powers, E E Jones, E Bruner, A S Mehta, P M Angel
Glycosylated proteins account for a majority of the posttranslation modifications of cell surface, secreted, and circulating proteins. Within the tumor microenvironment, the presence of immune cells, extracellular matrix proteins, cell surface receptors, and interactions between stroma and tumor cells are all processes mediated by glycan binding and recognition reactions. Changes in glycosylation during tumorigenesis are well documented to occur and affect all of these associated adhesion and regulatory functions...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28110656/assessing-the-potential-of-metal-assisted-imaging-mass-spectrometry-in-cancer-research
#18
M Dufresne, N H Patterson, N Lauzon, P Chaurand
In the last decade, imaging mass spectrometry (IMS) has been the primary tool for biomolecular imaging. While it is possible to map a wide range of biomolecules using matrix-assisted laser desorption/ionization IMS ranging from high-molecular-weight proteins to small metabolites, more often than not only the most abundant easily ionisable species are detected. To better understand complex diseases such as cancer more specific and sensitive methods need to be developed to enable the detection of lower abundance molecules but also molecules that have yet to be imaged by IMS...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28110650/maldi-ims-and-cancer-tissue-microarrays
#19
R Casadonte, R Longuespée, J Kriegsmann, M Kriegsmann
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) technology creates a link between the molecular assessment of numerous molecules and the morphological information about their special distribution. The application of MALDI IMS on formalin-fixed paraffin-embedded (FFPE) tissue microarrays (TMAs) is suitable for large-scale discovery analyses. Data acquired from FFPE TMA cancer samples in current research are very promising, and applications for routine diagnostics are under development...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28108072/treatment-of-metastatic-breast-cancer-in-eu-analysis-of-market-research-data-from-4q2013-till-3q2014
#20
Mario Cepparulo, Nina Schmidt
OBJECTIVE: Despite the scientific evidence undoubtedly influencing current guidelines on the management of metastatic Breast cancer (mBC), marketing research data suggests this may not be reflected in EU prescribing behavior. Specifically we would like to understand the use of combination chemotherapy vs monotherapy in mBC patients. METHODOLOGY: This study is based on IMS Oncology Analyzer™, a web-based physician panel survey set-up by IMS Health, a global company which specializes in health care information including market research data...
January 17, 2017: Breast: Official Journal of the European Society of Mastology
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