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https://www.readbyqxmd.com/read/28933337/the-polymorphism-of-cyp2d6-affects-the-pharmacokinetics-and-dose-escalation-of-paroxetine-controlled-release-tablet-in-healthy-chinese-subjects%C3%A2
#1
Rui Chen, Kai Shen, Pei Hu
PURPOSE: This study evaluated the effects of CYP2D6 polymorphisms on the pharmacokinetics and dose escalation of controlled-release paroxetine over the dose range of 12.5 - 37.5 mg in healthy Chinese subjects. MATERIALS AND METHODS: This was a phase I, open-label, single-dose, three-period crossover study in which 12 healthy subjects received single oral doses of 12.5, 25, and 37.5 mg paroxetine controlled-release tablets with 10-day washout between doses. Serial venous blood samples were collected for 96 hours after study-drug administration and analyzed with LC-MS/MS...
September 21, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28933014/size-exclusion-chromatography-ion-mobility-mass-spectrometry-coupling-a-step-toward-structural-biology
#2
Guillaume Van der Rest, Frédéric Halgand
Noncovalent interactions are essential for the structural organization of biomacromolecules in cells. For this reason, the study of the biophysical, dynamic, and architectural interactions among biomacromolecules is essential. Since mass spectrometry requires compatible solutions while preserving the noncovalent bonding network, we envisioned that size exclusion chromatography coupled with ion mobility and mass spectrometry would be a valuable technique to desalt the initial sample and provide solution and gas-phase structural information in a single stage experiment...
September 20, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28932891/identification-of-terpenes-and-essential-oils-by-means-of-static-headspace-gas-chromatography-ion-mobility-spectrometry
#3
Roman Rodríguez-Maecker, Eduardo Vyhmeister, Stefan Meisen, Antonio Rosales Martinez, Andriy Kuklya, Ursula Telgheder
Static headspace gas chromatography-ion mobility spectrometry (SHS GC-IMS) is a relatively new analytical technique that has considerable potential for analysis of volatile organic compounds (VOCs). In this study, SHS GC-IMS was used for the identification of the major terpene components of various essential oils (EOs). Based on the data obtained from 25 terpene standards and 50 EOs, a database for fingerprint identification of characteristic terpenes and EOs was generated utilizing SHS GC-IMS for authenticity testing of fragrances in foods, cosmetics, and personal care products...
September 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28928177/adherence-and-dosing-interval-of-subcutaneous-antitumour-necrosis-factor-biologics-among-patients-with-inflammatory-arthritis-analysis-from-a-canadian-administrative-database
#4
Peter Bhoi, Louis Bessette, Mary J Bell, Cathy Tkaczyk, Francois Nantel, Karina Maslova
OBJECTIVES: Subcutaneous tumour necrosis factor alpha TNFαinhibitors (SC-TNFis) such as golimumab (GLM), adalimumab (ADA), etanercept (ETA) and certolizumab pegol (CZP) have been used for many years for the treatment of inflammatory arthritis. Non-adherence to therapy is an important modifiable factor that may compromise patient outcomes. The aim of this analysis was to compare adherence and dosing interval of SC-TNFis in the treatment of people with inflammatory arthritis. DESIGN: We used the IMS Brogan database combining both Canadian private and public drug plan databases of Ontario and Quebec...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28925253/novel-trimodal-maldi-imaging-mass-spectrometry-ims3-at-10-%C3%AE-m-reveals-spatial-lipid-and-peptide-correlates-implicated-in-a%C3%AE-plaque-pathology-in-alzheimer-s-disease
#5
Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Mehmet Baskurt, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder
Multimodal chemical imaging using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can provide comprehensive molecular information in situ within the same tissue sections. This is of relevance for studying different brain pathologies such as Alzheimer's Disease (AD), where recent data suggest a critical relevance of co-localizing Aβ peptides and neuronal lipids. We here developed a novel trimodal, high-resolution (10µm) MALDI imaging MS (IMS) paradigm for negative- and positive ion mode lipid analysis and subsequent protein ion imaging on the same tissue section...
September 19, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28918604/symptom-experience-of-multiple-myeloma-symmex-patients-treated-with-autologous-stem-cell-transplantation-following-high-dose-melphalan-a-descriptive-longitudinal-study
#6
Matthias Naegele, Monika Kirsch, Gabriele Ihorst, Katharina Fierz, Monika Engelhardt, Sabina De Geest
PURPOSE: High-dose melphalan and autologous stem cell transplantation (ASCT) are associated with high symptom burden. This study aimed to explore multiple myeloma (MM) patients' experience of symptom frequency, intensity, and distress during therapy. METHODS: This descriptive longitudinal study enrolled 29 MM patients who completed the 43-item PROVIVO questionnaire, measuring symptom experience across the dimensions of frequency, intensity, and distress at four assessment points: hospital admission (T0), leucocyte nadir (T1), discharge (T2), and 30 days post discharge (T3)...
September 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28917748/selectivity-improvement-of-positive-photoionization-ion-mobility-spectrometry-for-rapid-detection-of-organophosphorus-pesticides-by-switching-dopant-concentration
#7
Qinghua Zhou, Jia Li, Bin Wang, Shuang Wang, Haiyang Li, Jinyuan Chen
Ion mobility spectrometry (IMS) opened a potential avenue for the rapid detection of organophosphorus pesticides (OPPs), though an improved selectivity of stand-alone IMS was still in high demand. In this study, a stand-alone positive photoionization ion mobility spectrometry (PP-IMS) apparatus was constructed for the rapid detection of OPPs with acetone as dopant. The photoionization of acetone molecules was induced by the ultraviolet irradiation to produce the reactant ions (Ac)2H(+), which were employed to ionize the OPPs including fenthion, imidan, phosphamidon, dursban, dimethoate and isocarbophos via the proton transfer reaction...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917733/stabilization-of-gas-phase-uranyl-complexes-enables-rapid-speciation-using-electrospray-ionization-and-ion-mobility-mass-spectrometry
#8
Austen L Davis, Brian H Clowers
Significant challenges exist when characterizing f-element complexes in solution using traditional approaches such as electrochemical and spectroscopic techniques as they do not always capture information for lower abundance species. However, provided a metal-complex with sufficient stability, soft ionization techniques such as electrospray offer a means to quantify and probe the characteristics of such systems using mass spectrometry. Unfortunately, the gas-phase species observed in ESI-MS systems do not always reflect the solution phase distributions due to the inherent electrochemical mechanism of the electrospray process, ion transfer from ambient to low pressures conditions, and other factors that are related to droplet evaporation...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28915520/-effect-of-the-disease-management-program-on-hba1c-value-in-type-2-diabetes-mellitus-patients-a-retrospective-comparison-between-disease-management-programs-and-standard-care
#9
Stefan Wiefarn, Karel Kostev, Christian Heumann, Anja Rettelbach
Background This retrospective study aims to measure the effect of the disease management program (DMP) for type 2 diabetes mellitus (T2DM) patients on HbA1c value within Germany. Methods This study is based on patient data from the Disease Analyzer panel (IMS Health). An adequate control group was created using 2:1 propensity score matching. After matching, the analysis included 14 759 patients. Of these, 5875 participated in a DMP while 8884 received standard care. The DMP effect was estimated on the basis of the matched data, using an unpaired t-test...
September 15, 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28910355/effects-of-reduced-nitrogen-inputs-on-crop-yield-and-nitrogen-use-efficiency-in-a-long-term-maize-soybean-relay-strip-intercropping-system
#10
Ping Chen, Qing Du, Xiaoming Liu, Li Zhou, Sajad Hussain, Lu Lei, Chun Song, Xiaochun Wang, Weiguo Liu, Feng Yang, Kai Shu, Jiang Liu, Junbo Du, Wenyu Yang, Taiwen Yong
The blind pursuit of high yields via increased fertilizer inputs increases the environmental costs. Relay intercropping has advantages for yield, but a strategy for N management is urgently required to decrease N inputs without yield loss in maize-soybean relay intercropping systems (IMS). Experiments were conducted with three levels of N and three planting patterns, and dry matter accumulation, nitrogen uptake, nitrogen use efficiency (NUE), competition ratio (CR), system productivity index (SPI), land equivalent ratio (LER), and crop root distribution were investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28910313/a-detailed-comparison-of-analysis-processes-for-mcc-ims-data-in-disease-classification-automated-methods-can-replace-manual-peak-annotations
#11
Salome Horsch, Dominik Kopczynski, Elias Kuthe, Jörg Ingo Baumbach, Sven Rahmann, Jörg Rahnenführer
MOTIVATION: Disease classification from molecular measurements typically requires an analysis pipeline from raw noisy measurements to final classification results. Multi capillary column-ion mobility spectrometry (MCC-IMS) is a promising technology for the detection of volatile organic compounds in the air of exhaled breath. From raw measurements, the peak regions representing the compounds have to be identified, quantified, and clustered across different experiments. Currently, several steps of this analysis process require manual intervention of human experts...
2017: PloS One
https://www.readbyqxmd.com/read/28904294/assessment-of-amiodarone-induced-phospholipidosis-in-chimeric-mice-with-a-humanized-liver
#12
Seigo Sanoh, Yuto Yamachika, Yuka Tamura, Yaichiro Kotake, Yasumi Yoshizane, Yuji Ishida, Chise Tateno, Shigeru Ohta
It is important to consider susceptibility to drug-induced toxicity between animals and humans. Chimeric mice with a humanized liver are expected to predict hepatotoxicity in humans. Drug-induced phospholipidosis (DIPL), in which phospholipids accumulate, is a known entity. In this study, we examined whether chimeric mice can reveal species differences in DIPL. Changes in various phosphatidylcholine (PhC) molecules were investigated in the liver of chimeric mice after administering amiodarone, which induces phospholipidosis...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28901031/isomer-separation-and-effect-of-the-polymerization-degree-on-the-gas-phase-structure-of-chondroitin-sulfate-oligosaccharides-analyzed-by-ion-mobility-tandem-mass-spectrometry
#13
Salomé Poyer, Chrystel Lopin-Bon, Jean-Claude Jacquinet, Jean-Yves Salpin, Régis Daniel
RATIONALE: Chondroitin sulfate (CS) glycosaminoglycans are bioactive sulfated polysaccharides comprising repeating units of uronic acid and N-acetyl galactose sulfated at various positions. The optimal length and sulfation pattern of the CS bioactive sequences remain elusive so that structure-activity relationship cannot be easily established. Development of efficient analytical methods allowing the differentiation of the various sulfation patterns of CS sequences is therefore of particular importance to correlate their biological functions to the sulfation pattern...
September 12, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28895104/concordance-of-adherence-measurement-using-self-reported-adherence-questionnaires-and-medication-monitoring-devices-an-updated-review
#14
REVIEW
Alisha Monnette, Yichen Zhang, Hui Shao, Lizheng Shi
INTRODUCTION: As medication adherence continues to be a prevalent issue in today's society, the methods used to monitor medication-taking behaviors are constantly being re-evaluated and compared in search of the 'gold standard' measure. Our review aimed to assess the current literature surrounding the correlation between self-reported questionnaires (SRQs) and electronic monitoring devices to determine if these measures produce similar results. METHODS: We performed a literature search from 2009 to 2017 using PubMed, PubMed In-Process and Non-Indexed, EMBASE, Ovid MEDLINE, and Ovid MEDLINE In-Process...
September 11, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28893672/a-situational-analysis-of-current-antimicrobial-governance-regulation-and-utilisation-in-south-africa
#15
Natalie Schellack, Deon Benjamin, Adrian Brink, Adriano Duse, Kim Faure, Debra Goff, Marc Mendelson, Johanna Meyer, Jacqui Miot, Olga Perovic, Troy Pople, Fatima Suleman, Moritza van Vuuren, Sabiha Essack
The Global Action Plan (GAP) on AMR calls for optimising the use of antimicrobial medicines in human and animal health, in tandem with strengthening of the knowledge and evidence base through surveillance and research. However, there is a paucity of consumption data in African countries such as South Africa. Determining antimicrobial consumption data in low resource settings remains a challenge. This paper describes alternative mechanisms of assessing antimicrobial consumption data such as Intercontinental Marketing Services (IMS), and contract data arising from tenders (an open Request for Proposal, RFP) as opposed to the international norms of daily defined doses per 100 patient days, or per 1000 of the population...
September 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28890335/the-er-localized-transmembrane-protein-epg-3-vmp1-regulates-serca-activity-to-control-er-isolation-membrane-contacts-for-autophagosome-formation
#16
Yan G Zhao, Yong Chen, Guangyan Miao, Hongyu Zhao, Wenyan Qu, Dongfang Li, Zheng Wang, Nan Liu, Lin Li, She Chen, Pingsheng Liu, Du Feng, Hong Zhang
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts. Loss of VMP1 causes stable association of IMs with the ER, thus blocking autophagosome formation. Interaction of WIPI2 with the ULK1/FIP200 complex and PI(3)P contributes to the formation of ER-IM contacts, and these interactions are enhanced by VMP1 depletion. VMP1 controls contact formation by promoting SERCA (sarco[endo]plasmic reticulum calcium ATPase) activity...
September 21, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28888687/temporary-removal-rapid-screening-of-abused-drugs-by-direct-analysis-in-real-time-dart-coupled-to-time-of-flight-mass-spectrometry-tof-ms-combined-with-ion-mobility-spectrometry-ims
#17
Ru Lian, Zhongping Wu, Xiaobao Lv, Yulan Rao, Haiyang Li, Jinghua Li, Rong Wang, Chunfang Ni, Yurong Zhang
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
July 13, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28883469/characteristics-of-newly-diagnosed-copd-patients-treated-with-triple-inhaled-therapy-by-general-practitioners-a-real-world-italian-study
#18
Fabiano Di Marco, Pierachille Santus, Silvia Terraneo, Elena Peruzzi, Elisa Muscianisi, Claudio Ripellino, Valeria Pegoraro
Factors predicting prescriptions of triple therapy were investigated in a large group of general practitioners in Italy. In the population treated by identified general practitioners, a cohort of newly diagnosed chronic obstructive pulmonary disease patients was extracted from IMS Health Longitudinal Database during the period 2010-2013. From the diagnosis, 1-year follow-up was evaluated. Thirty-two thousand forty-six newly diagnosed chronic obstructive pulmonary disease patients were evaluated (57.7% male, mean age 67 years)...
September 7, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28882491/anatomic-and-high-resolution-computed-tomographic-angiography-study-of-the-lateral-femoral-condyle-flap-implications-for-surgical-dissection
#19
Mohamed Morsy, Yoo Joon Sur, Osman Akdag, Amr Eisa, Tarek A El-Gammal, Nirusha Lachman, Steven L Moran
BACKGROUND: The lateral femoral condyle (LFC) flap is a vascularized bone flap based on the superior lateral genicular artery (SLGA). Harvest technique for this flap has not yet been demonstrated. The purpose of this study was to better delineate the blood supply to the bone and skin of this flap to allow for a safe and effective harvest. MATERIALS AND METHODS: Twenty-three lower extremities were injected with latex or a mixture of latex and barium sulfate. The SLGA was identified and dissected, documenting the course, diameter, anatomical relations, length, and branches...
August 16, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28882075/comparative-treatment-related-adverse-event-cost-burden-in-immune-thrombocytopenic-purpura
#20
Prina Z Donga, Sara P Bilir, Gregg Little, Tim Babinchak, Julie Munakata
AIMS: Real-world evidence on the safety profile and costs associated with immune thrombocytopenic purpura (ITP) treatment in adults is lacking. This study quantifies and compares adverse event (AE) crude rates and costs associated with ITP treatments as found in claims data. MATERIALS AND METHODS: A retrospective claims-based analysis was conducted using IMS Pharmetrics Plus database. Included patients were ≥18 years old, with a diagnosis of ITP (2007-2012); an ITP-related claim for anti-D, intravenous immunoglobulin (IVIG), rituximab, romiplostim, or eltrombopag; and 1-year continuous enrollment (3-years for rituximab) during follow-up...
September 8, 2017: Journal of Medical Economics
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