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https://www.readbyqxmd.com/read/29777108/factor-xiiia-expressing-inflammatory-monocytes-promote-lung-squamous-cancer-through-fibrin-cross-linking
#1
Alessandro Porrello, Patrick L Leslie, Emily B Harrison, Balachandra K Gorentla, Sravya Kattula, Subrata K Ghosh, Salma H Azam, Alisha Holtzhausen, Yvonne L Chao, Michele C Hayward, Trent A Waugh, Sanggyu Bae, Virginia Godfrey, Scott H Randell, Cecilia Oderup, Liza Makowski, Jared Weiss, Matthew D Wilkerson, D Neil Hayes, H Shelton Earp, Albert S Baldwin, Alisa S Wolberg, Chad V Pecot
Lung cancer is the leading cause of cancer-related deaths worldwide, and lung squamous carcinomas (LUSC) represent about 30% of cases. Molecular aberrations in lung adenocarcinomas have allowed for effective targeted treatments, but corresponding therapeutic advances in LUSC have not materialized. However, immune checkpoint inhibitors in sub-populations of LUSC patients have led to exciting responses. Using computational analyses of The Cancer Genome Atlas, we identified a subset of LUSC tumors characterized by dense infiltration of inflammatory monocytes (IMs) and poor survival...
May 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29776547/on-the-potential-of-ion-mobility-spectrometry-coupled-to-gc-pre-separation-a-tutorial
#2
REVIEW
Wolfgang Vautz, Joachim Franzke, Stefano Zampolli, Ivan Elmi, Sascha Liedtke
In this tutorial, we want to demonstrate the significant potential of ion mobility spectrometry (IMS), an analytical technique for identification and quantification of gas-phase compounds, in particular combined to other useful analytical tools. Coupled to gas-chromatographic pre-separation (GC-IMS), selectivity can be improved significantly, thus enabling the analysis of complex, humid mixtures. In-line pre-concentration can improve sensitivity down to the ppqV range. Furthermore, the use of non-radioactive ionisation sources in the near future could gain acceptance and will avoid legal restrictions...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29774653/matrix-glycoprotein-interactions-required-for-budding-of-a-plant-nucleorhabdovirus-and-induction-of-inner-nuclear-membrane-invagination
#3
Kai Sun, Xin Zhou, Wenye Lin, Xueping Zhou, Andrew O Jackson, Zhenghe Li
Nucleorhabdoviruses such as Sonchus yellow net virus (SYNV) replicate in the nuclei and undergo morphogenesis at the inner nuclear membrane (IM) in plant cells. Mature particles are presumed to form by budding of the Matrix (M) protein-nucleocapsid complexes through host IMs to acquire host phospholipids and the surface glycoproteins (G). To address mechanisms underlying nucleorhabdovirus budding, we generated recombinant SYNV G mutants containing a truncated amino-terminal (NT) or carboxyl-terminal (CT) domain...
May 18, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29761388/isolation-and-identification-of-interstitial-macrophages-from-the-lungs-using-different-digestion-enzymes-and-staining-strategies
#4
Shaikh M Atif, Sophie L Gibbings, Claudia V Jakubzick
Interstitial macrophages (IMs) are present in multiple organs. Although there is limited knowledge of the unique functional role IM subtypes play, macrophages, in general, are known for their contribution in homeostatic tissue maintenance and inflammation such as clearing pathogens and debris and secreting inflammatory mediators and growth factors. IM subtypes have been identified in the heart, skin, and gut, and more recently we identified three distinct IMs in the lung. IMs express on their surface high levels of MerTK, CD64, and CD11b, with differences in CD11c, CD206, and MHC II expression, and referred to the three pulmonary IM subtypes as IM1 (CD11clo CD206+ MHCIIlo ), IM2 (CD11clo CD206+ MHCIIhi ), and IM3 (CD11chi CD206lo MHCIIhi )...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29760879/smell-the-change-on-the-potential-of-gas-chromatographic-ion-mobility-spectrometry-in-ecosystem-monitoring
#5
Wolfgang Vautz, Chandrasekhara Hariharan, Maximilian Weigend
Plant volatile organic compounds (pVOCs) are being recognized as an important factor in plant-environment interactions. Both the type and amount of the emissions appear to be heavily affected by climate change. A range of studies therefore has been directed toward understanding pVOC emissions, mostly under laboratory conditions (branch/leaf enclosure). However, there is a lack of rapid, sensitive, and selective analytical methods, and therefore, only little is known about VOC emissions under natural, outdoor conditions...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29759238/ion-mobility-spectrometer-with-orthogonal-x-ray-source-for-increased-sensitivity
#6
Erik Bunert, Tobias Reinecke, Ansgar T Kirk, Alexander Bohnhorst, Stefan Zimmermann
Ion mobility spectrometers (IMS) are compact devices for extremely sensitive detection of proton and electron affine volatile compounds down to low pptv concentrations within less than a second. The measuring principle requires ionization of the target analyte. Most IMS employ radioactive electron sources, such as 63 Ni or 3 H. These radioactive materials suffer from legal restrictions limiting the fields of application. Furthermore, the electron emission has a predetermined intensity and cannot be controlled or disabled...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29756663/coupling-trapped-ion-mobility-spectrometry-to-mass-spectrometry-tims-tof-ms-vs-tims-ft-icr-ms
#7
Lilian V Tose, Paolo Benigni, Dennys Leyva, Abigail Sundberg, César E Ramírez, Mark E Ridgeway, Melvin A Park, Wanderson Romão, Rudolf Jaffé, Francisco Fernandez-Lima
RATIONALE: There is a need for fast, post-ionization separation during the analysis of complex mixtures. In this study, we evaluate the use of a high-resolution mobility analyzer with high resolution and ultra-high-resolution mass spectrometry for unsupervised molecular feature detection. Goals include the study of the reproducibility of TIMS across platforms, applicability range and potential challenges during routine analysis. METHODS: A TIMS analyzer was coupled to TOF-MS and to an FT-ICR MS for the analysis of single charge species in the m/z 150-800 range of a complex mixture (Suwannee River Fulvic Acid Standard)...
May 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29754423/imaging-mass-spectrometry-for-characterization-of-atrial-fibrillation-subtypes
#8
Oliver Klein, Thorsten Hanke, Grit Nerbrich, Junfeng Yan, Benedikt Schubert, Patrick Giavalisco, Frank Noack, Herbert Thiele, Salah A Mohamed
PURPOSE: Atrial fibrillation (AF) is a cardiac arrhythmia characterized by a rapid and irregular heart rhythm. AF types, paroxysmal (PX), persistent (PE) and long-lasting persistent (LSP), requires differences in clinical management. Unfortunately, a significant proportion of AF patients are clinical misclassified. Therefore, our study aim that MALDI-Imaging (IMS) is valuable as a diagnostic aid in AF subtypes assessment. EXPERIMENTAL DESIGN: Patients were clinically classified according guidelines of the European Society of Cardiology...
May 13, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29753352/patient-access-to-medicines-for-rare-diseases-in-european-countries
#9
Andreja Detiček, Igor Locatelli, Mitja Kos
BACKGROUND: The number of authorized orphan and non-orphan medicines for rare diseases has increased in Europe. Patient access to these medicines is affected by high costs, weak efficacy/safety evidence, and societal value. European health care systems must determine whether paying for expensive treatments for only a few patients is sustainable. OBJECTIVES: This study aimed to evaluate patient access to orphan and non-orphan medicines for rare diseases in 22 European countries during 2005 to 2014...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29748547/region-of-interest-analysis-using-mass-spectrometry-imaging-of-mitochondrial-and-sarcomeric-proteins-in-acute-cardiac-infarction-tissue
#10
Yuka Yajima, Takuya Hiratsuka, Yu Kakimoto, Shuichiro Ogawa, Keisuke Shima, Yuzo Yamazaki, Kenichi Yoshikawa, Keiji Tamaki, Tatsuaki Tsuruyama
Matrix-assisted laser desorption ionization image mass spectrometry (MALDI-IMS) has been developed for the identification of peptides in various tissues. The MALDI-IMS signal distribution patterns and quantification of the signal intensities of the regions of interest (ROI) with healthy regions were compared for identification of the disease specific biomarkers. We performed a new ROI analysis using the conventional t-test and data number independent Cohen's d-value analysis. Using these techniques, we analysed heart tissues after acute myocardial infarction (AMI)...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29747662/progressive-mobility-program-and-technology-to-increase-the-level-of-physical-activity-and-its-benefits-in-respiratory-muscular-system-and-functionality-of-icu-patients-study-protocol-for-a-randomized-controlled-trial
#11
Debora Stripari Schujmann, Adriana Claudia Lunardi, Carolina Fu
BACKGROUND: Enhanced mobility in the Intensive Care Unit (ICU) could minimize the negative effects of critical illness, such as declines in cognitive, muscular, respiratory, and functional capacity. We aim to compare the functional status at ICU discharge of patients who underwent a progressive mobilization protocol versus patients who received conventional physiotherapy. We also examine the level of physical activity in the ICU, the degree of pulmonary and muscle function, and the length of stay to analyze correlations between these variables...
May 10, 2018: Trials
https://www.readbyqxmd.com/read/29746100/combining-ion-mobility-and-cryogenic-spectroscopy-for-structural-and-analytical-studies-of-biomolecular-ions
#12
Michael Z Kamrath, Thomas R Rizzo
Ion mobility spectrometry (IMS) has become a valuable tool in biophysical and bioanalytical chemistry because of its ability to separate and characterize the structure of gas-phase biomolecular ions on the basis of their collisional cross section (CCS). Its importance has grown with the realization that in many cases, biomolecular ions retain important structural characteristics when produced in the gas phase by electrospray ionization (ESI). While a CCS can help distinguish between structures of radically different types, one cannot expect a single number to differentiate similar conformations of a complex molecule...
May 10, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29740761/a-simple-analytical-model-for-predicting-the-detectable-ion-current-in-ion-mobility-spectrometry-using-corona-discharge-ionization-sources
#13
Ansgar Thomas Kirk, Tim Kobelt, Hauke Spehlbrink, Stefan Zimmermann
Corona discharge ionization sources are often used in ion mobility spectrometers (IMS) when a non-radioactive ion source with high ion currents is required. Typically, the corona discharge is followed by a reaction region where analyte ions are formed from the reactant ions. In this work, we present a simple yet sufficiently accurate model for predicting the ion current available at the end of this reaction region when operating at reduced pressure as in High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) or most IMS-MS instruments...
May 8, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29739294/the-mixed-outcomes-of-taking-ownership-for-implicit-racial-biases
#14
Erin Cooley, Ryan F Lei, Taylor Ellerkamp
One potential strategy for prejudice reduction is encouraging people to acknowledge, and take ownership for, their implicit biases. Across two studies, we explore how taking ownership for implicit racial bias affects the subsequent expression of overt bias. Participants first completed an implicit measure of their attitudes toward Black people. Then we either led participants to think of their implicit bias as their own or as stemming from external factors. Results revealed that taking ownership for high implicit racial bias had diverging effects on subsequent warmth toward Black people (Study 1) and donations to a Black nonprofit (Study 2) based on people's internal motivations to respond without prejudice (Internal Motivation Scale [IMS])...
May 1, 2018: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29735375/which-additional-augmented-fixation-procedure-decreases-surgical-failure-after-proximal-humeral-fracture-with-medial-comminution-fibular-allograft-or-inferomedial-screws
#15
Doo-Sup Kim, Doo-Hyung Lee, Yong-Min Chun, Sang-Jin Shin
BACKGROUND: The purpose of this study was to compare clinical and radiologic results between treatment with locking plate fixation and fibular allograft augmentation (FA) and treatment with locking plate fixation and additional inferomedial screws (IMSs) in 3- or 4-part proximal humeral fractures with medial comminution in geriatric patients. METHODS: We enrolled 164 patients with 3- or 4-part proximal humeral fractures with medial comminution who were treated with locking plates...
May 4, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29733584/native-electrospray-ionization-mass-spectrometry-reveals-multiple-facets-of-aptamer-ligand-interactions-from-mechanism-to-binding-constants
#16
Basri Gulbakan, Konstantin Barylyuk, Petra Schneider, Max Pillong, Gisbert Schneider, Renato Zenobi
Aptamers are oligonucleotide receptors obtained through an iterative selection process from random-sequence libraries. While many aptamers for a broad range of targets with high affinity and selectivity have been generated, a lack of high-resolution structural data and the limitations of currently available biophysical tools greatly impede understanding of the mechanisms of aptamer-ligand interactions. Here we demonstrate that an approach based on native electrospray ionization mass spectrometry (ESI-MS) can be successfully applied to characterize aptamer-ligand complexes in all details...
May 7, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29732610/image-reconstruction-algorithm-for-motion-insensitive-mr-fingerprinting-mrf-morf
#17
Bhairav Bipin Mehta, Dan Ma, Eric Yann Pierre, Yun Jiang, Simone Coppo, Mark Alan Griswold
PURPOSE: The purpose of this study is to increase the robustness of MR fingerprinting (MRF) toward subject motion. METHODS: A novel reconstruction algorithm, MOtion insensitive MRF (MORF), was developed, which uses an iterative reconstruction based retrospective motion correction approach. Each iteration loops through the following steps: pattern recognition, metric based identification of motion corrupted frames, registration based motion estimation, and motion compensated data consistency verification...
May 6, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29723122/antimicrobial-resistance-profiles-of-enterohemorrhagic-and-enteropathogenic-escherichia-coli-of-serotypes-o157-h7-o26-h11-o103-h2-o111-h8-o145-h28-compared-to-escherichia-coli-isolated-from-the-same-adult-cattle
#18
Maryse Michèle Um, Hubert Brugère, Monique Kérourédan, Eric Oswald, Delphine Bibbal
The aim of this study was to compare the antimicrobial resistance profiles of top five enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) to E. coli isolated from the fecal flora of the same adult cattle. Previous prevalence studies had led to the isolation by immunomagnetic separation (IMS) of 39 EHEC and 80 EPEC. Seven EHEC were resistant (17.9%), and six were multidrug resistant (MDR) (15.4%). None of the top five EHEC was resistant to azithromycin. Nine EPEC O26:H11 (11.3%) were resistant...
May 3, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29721555/metal-ions-induced-secondary-structure-rearrangements-mechanically-interlocked-lasso-vs-unthreaded-branched-cyclic-topoisomers
#19
Kevin Jeanne Dit Fouque, Javier Moreno, Julian D Hegemann, Séverine Zirah, Sylvie Rebuffat, Francisco Fernandez-Lima
Metal ions can play a significant role in a variety of important functions in protein systems including cofactor for catalysis, protein folding, assembly, structural stability and conformational change. In the present work, we examined the influence of alkali (Na, K and Cs), alkaline earth (Mg and Ca) and transition (Co, Ni and Zn) metal ions on the conformational space and analytical separation of mechanically interlocked lasso peptides. Syanodin I, sphingonodin I, caulonodin III and microcin J25, selected as models of lasso peptides, and their respective branched-cyclic topoisomers were submitted to native nESI trapped ion mobility spectrometry-mass spectrometry (TIMS-MS)...
May 3, 2018: Analyst
https://www.readbyqxmd.com/read/29714516/use-of-proprietary-names-by-prescribers-for-generic-products
#20
Vicky Borders-Hemphill, Irene Z Chan, Katelyn Brown, Briana Rider, Kellie Taylor, Grace Chai
BACKGROUND: Proprietary names are often used when prescribing drug products in the United States. The purpose of this study is to describe prescribers' use of proprietary names for generic products, branded-generic names, on prescription orders and to identify prescribing practice trends to inform the development and evaluation of new proprietary names. METHODS: To identify Abbreviated New Drug Application (ANDA) with branded-generic names approved between January 2003 and December 2012, we utilized the database provided by the FDA Office of Communications, Drugs@FDA ...
March 2018: Therapeutic Innovation & Regulatory Science
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