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https://www.readbyqxmd.com/read/29668128/tuberculosis-associated-with-tumor-necrosis-factor-%C3%AE-antagonists-case-description-and-analysis-of-reported-cases-in-colombia
#1
Leandro Galvis, Ángel Y Sánchez, Leonardo F Jurado, Martha I Murcia
Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668079/co-culture-of-adipose-derived-stem-cells-and-chondrocytes-on-three-dimensionally-printed-bioscaffolds-for-craniofacial-cartilage-engineering
#2
Robert J Morrison, Hassan B Nasser, Khaled N Kashlan, David A Zopf, Derek J Milner, Colleen L Flanangan, Matthew B Wheeler, Glenn E Green, Scott J Hollister
OBJECTIVES/HYPOTHESIS: Reconstruction of craniofacial cartilagenous defects are among the most challenging surgical procedures in facial plastic surgery. Bioengineered craniofacial cartilage holds immense potential to surpass current reconstructive options, but limitations to clinical translation exist. We endeavored to determine the viability of utilizing adipose-derived stem cell-chondrocyte co-culture and three-dimensional (3D) printing to produce 3D bioscaffolds for cartilage tissue engineering...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668041/warming-intensify-co-2-flux-and-nutrient-release-from-algal-wrack-subsidies-on-sandy-beaches
#3
M Lastra, J López, I F Rodil
Algal wrack subsidies underpin most of the food web structure of exposed sandy beaches, and are responsible of important biogeochemical processes that link marine and terrestrial ecosystems. The response in decomposition of algal wrack deposits to global warming has not been studied in ocean exposed sandy beaches to date. With this aim, passive open top chambers (OTCs) were used to increase soil temperature within the range predicted by the IPCC for western Europe (between 0.5 and 1.5 °C), following the hypothesis that the biogeochemical processing of macroalgal wrack subsidies would accelerate in response to temperature increase...
April 18, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29668026/nicu-graduates-the-role-of-the-allied-health-team-in-follow-up
#4
Jane L Orton, Joy E Olsen, Katherine Ong, Rochelle Lester, Alicia J Spittle
Infants who graduate from the neonatal intensive care unit, including those infants born preterm and/or with brain injury, are at increased risk of long-term neurodevelopmental impairments. The developmental allied health team, consisting of physical therapy, occupational therapy, and speech pathology, is crucial in early evaluation of gross motor, fine motor, feeding, and language development. Surveillance of neurodevelopment in the first year of life is essential to ensure early detection of specific developmental delays and impairments, and to ensure timely referral for early intervention...
April 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29667925/massive-over-representation-of-solute-binding-proteins-sbps-from-the-tripartite-tricarboxylate-transporter-ttt-family-in-the-genome-of-the-%C3%AE-proteobacterium-rhodoplanes-sp-z2-yc6860
#5
Leonardo T Rosa, Vicki Springthorpe, Matheus E Bianconi, Gavin H Thomas, David J Kelly
Lineage-specific expansion (LSE) of protein families is a widespread phenomenon in many eukaryotic genomes, but is generally more limited in bacterial genomes. Here, we report the presence of 434 genes encoding solute-binding proteins (SBPs) from the tripartite tricarboxylate transporter (TTT) family, within the 8.2 Mb genome of the α-proteobacterium Rhodoplanes sp. Z2-YC6860, a gene family over-representation of unprecedented abundance in prokaryotes. Representing over 6 % of the total number of coding sequences, the SBP genes are distributed across the whole genome but are found rarely in low-GC islands, where the gene density for this family is much lower...
April 18, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29667921/glycemic-control-of-type-2-diabetes-mellitus-across-stages-of-renal-impairment-information-for-primary-care-providers
#6
Lili Tong, Sharon Adler
Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29667872/detecting-european-rabbit-oryctolagus-cuniculus-disease-outbreaks-by-monitoring-digital-media
#7
David E Peacock, Tiggy L Grillo
  Digital media and digital search tools offer simple and effective means to monitor for pathogens and disease outbreaks in target organisms. Using tools such as Rich Site Summary feeds, and Google News and Google Scholar specific key word searches, international digital media were actively monitored from 2012 to 2016 for pathogens and disease outbreaks in the taxonomic order Lagomorpha, with a specific focus on the European rabbit ( Oryctolagus cuniculus). The primary objective was identifying pathogens for assessment as potential new biocontrol agents for Australia's pest populations of the European rabbit...
April 18, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29667870/focus-is-key-panic-focused-interpretations-are-associated-with-symptomatic-improvement-in-panic-focused-psychodynamic-psychotherapy
#8
John R Keefe, Nili Solomonov, Robert J Derubeis, Alexander C Phillips, Fredric N Busch, Jacques P Barber, Dianne L Chambless, Barbara L Milrod
OBJECTIVE: This study examines whether, in panic-focused psychodynamic psychotherapy (PFPP), interpretations of conflicts that underlie anxiety (panic-focused or PF-interpretations) are specifically associated with subsequent panic disorder (PD) symptom improvement, over and above the provision of non-symptom-focused interpretations. METHOD: Technique use in Sessions 2 and 10 of a 24-session PFPP protocol was assessed for the 65 patients with complete outcome data randomized to PFPP in a two-site trial of psychotherapies for PD...
April 18, 2018: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/29667769/targeting-the-phosphatidylinositol-3-kinase-akt-mechanistic-target-of-rapamycin-signaling-pathway-in-b-lineage-acute-lymphoblastic-leukemia-an-update
#9
REVIEW
Carolina Simioni, Alberto M Martelli, Giorgio Zauli, Marco Vitale, James A McCubrey, Silvano Capitani, Luca M Neri
Despite considerable progress in treatment protocols, B-lineage acute lymphoblastic leukemia (B-ALL) displays a poor prognosis in about 15-20% of pediatric cases and about 60% of adult patients. In addition, life-long irreversible late effects from chemo- and radiation therapy, including secondary malignancies, are a growing problem for leukemia survivors. Targeted therapy holds promising perspectives for cancer treatment as it may be more effective and have fewer side effects than conventional therapies. The phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway is a key regulatory cascade which controls proliferation, survival and drug-resistance of cancer cells, and it is frequently upregulated in the different subtypes of B-ALL, where it plays important roles in the pathophysiology, maintenance and progression of the disease...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29667751/suz12-is-a-novel-putative-oncogene-promoting-tumorigenesis-in-head-and-neck-squamous-cell-carcinoma
#10
Yaping Wu, Huijun Hu, Wei Zhang, Zhongwu Li, Pengfei Diao, Dongmiao Wang, Wei Zhang, Yanling Wang, Jianrong Yang, Jie Cheng
The suppressor of zest 12 (SUZ12), one of the core polycomb repressive complex 2 (PRC2) components, has increasingly appreciated as a key mediator during human tumorigenesis. However, its expression pattern and oncogenic roles in head and neck squamous cell carcinoma (HNSCC) remain largely unexplored yet. Here, we sought to determine its expression pattern, clinicopathological significance and biological roles in HNSCC. Through data mining and interrogation from multiple publicly available databases, our bioinformatics analyses revealed that SUZ12 mRNA was significantly overexpressed in multiple HNSCC patient cohorts...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29667749/effect-of-lysm-macrophage-depletion-on-lung-pathology-in-mice-with-chronic-bronchitis
#11
Yogesh Saini, Brandon W Lewis, Dongfang Yu, Hong Dang, Alessandra Livraghi-Butrico, Fabio Del Piero, Wanda K O'Neal, Richard C Boucher
Macrophages (MΦ) are key sentinels of respiratory exposure to inhaled environmental stimuli. In normal "healthy" tissues, MΦ are believed to be a dormant cell type that, upon exposure to stress-causing stimuli, may get activated to exhibit pro- or anti-inflammatory roles. To test whether stress present in chronic bronchitic (CB) airways triggers MΦ to manifest protective or detrimental responses, the DTA+ (LysM-regulated Diphtheria Toxin A expressing) strain with partial MΦ-deficiency was crossed with the Scnn1b-Tg mouse model of CB and the progenies were studied at 4-5 weeks of age...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29667747/self-assembled-cyclic-structures-from-copper-ii-peptoids
#12
Totan Ghosh, Natalia Fridman, Monica Kosa, Galia Maayan
Metal-ligand coordination is a key interaction in the self-assembly of biopolymers. Although binding of metal ions to synthetic proteins and peptides is known to yield high-order structures, self-assembly of peptidomimetic molecules upon metal binding is still challenging. Herein we explore the self-assembly of three peptoid trimers 3, 3A and 3B, bearing a bipyridine ligand at their C-terminus, a benzyl group at their N-terminus and a polar group (N-ethyl-R) in the middle position (R = OH, OCH3 and NH2, respectively) by Cu2+ coordination...
April 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29667737/one-size-does-not-fit-all-addressing-the-challenges-of-intervention-for-complex-developmental-issues
#13
EDITORIAL
Courtenay Frazier Norbury
The Journal of Child Psychology and Psychiatry is committed to publishing implementational research, or turning therapeutic research discoveries into practical benefit for human health and well-being. This editorial showcases three such papers in this issue from diverse fields in developmental science. The papers highlight the challenges of implementing intervention under real-world constraints, and highlight key issues that clinicians and researchers will need to address in future work. Despite these challenges, each approach shows promise and innovation in delivering high-quality interventions to vulnerable children and families...
May 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29667726/interventions-for-infantile-haemangiomas-of-the-skin
#14
REVIEW
Monica Novoa, Eulalia Baselga, Sandra Beltran, Lucia Giraldo, Ali Shahbaz, Hector Pardo-Hernandez, Ingrid Arevalo-Rodriguez
BACKGROUND: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. This is an update of a Cochrane Review first published in 2011...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29667695/walking-on-eggshells-addressing-nursing-students-fear-of-the-psychiatric-clinical-setting
#15
Samuel P Abraham, Connie Cramer, Helen Palleschi
The current article discusses the feelings of nursing students as they enter their psychiatric rotation. Most nursing students are apprehensive of the psychiatric clinical setting. After more than 25 years of teaching, observing, and listening to remarks from students, the current researchers have discovered two major situations nursing students fear most about the psychiatric clinical setting: handling an assaultive patient and communication. Students have heard stories from the media and come with preconceived ideas about the psychiatric setting...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29667684/interaction-of-na-k-mg-2-and-ca-2-counter-cations-with-rna
#16
REVIEW
Stefan K Kolev, Petko St Petkov, Miroslav A Rangelov, Dimitar V Trifonov, Teodor I Milenov, Georgi N Vayssilov
Alkaline and alkaline earth ions, namely Na+, K+, Mg2+ and Ca2+, are critical for the stability, proper folding and functioning of RNA. Moreover, those metal ions help to facilitate macromolecular interactions as well as the formation of supramolecular structures (e.g. the ribosome and the ribozymes). Therefore, identifying the interactions between ions and nucleic acids is a key to the better comprehension of the physical nature and biological functions of those biomolecules. The scope of this review is to highlight the preferential location and binding sites of alkaline and alkaline earth metal ions compensating the negatively charged backbone of nucleic acids and interacting with other electronegative centers, focusing on RNA...
April 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29667677/theoretical-determination-of-adsorption-and-ionisation-energies-of-polycyclic-aromatic-hydrocarbons-on-water-ice
#17
Eric Michoulier, Nadia Ben Amor, Mathias Rapacioli, Jennifer A Noble, Joëlle Mascetti, Céline Toubin, Aude Simon
In dense interstellar environments, Polycyclic Aromatic Hydrocarbons (PAHs) are likely to condense onto or integrate into water ice mantles covering dust grains. Understanding the role of ice in the photo-induced processes involving adsorbed PAHs is therefore a key issue in astrochemistry. This requires (i) the knowledge of PAH-ice interactions, i.e. PAH-ice adsorption energies and local structures at the PAH-ice interface, as well as (ii) the understanding of the fate of electrons in the PAH-ice system upon excitation...
April 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29667607/blunt-abdominal-trauma-following-gunshot-wound-case-report-and-literature-review
#18
Myftar Torba, Arben Gjata, Francesco Rulli, Ilir Kajo, Sotir Ceka, Afron Mici
Blunt abdominal trauma following gunshot wound. Case report and literature review Introduction: Similarly to blast weapons, every firearm produces explosion at the moment of shooting, which can cause injuries in every region of the body. The aim of this paper is to present the mechanism of blunt abdominal injury following gunshot wounds, bringing this uncommon disease to the clinicians' attention and to review the literature available. CASE REPORT: A patient developed a delayed bowel perforation following a gunshot injury of the abdomen without breaking of the peritoneum...
April 20, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29667601/probing-ionization-potential-electron-affinity-and-self-energy-effect-on-the-spectral-shape-and-exciton-binding-energy-of-quantum-liquid-water-with-self-consistent-many-body-perturbation-theory-and-bethe-salpeter-equation
#19
Vafa Ziaei, Thomas Bredow
An accurate theoretical prediction of ionization potential (IP) and electron
 affinity (EA) is key for understanding of complex photochemical processes in
 aqueous environments. There have been numerous efforts in literature to
 accurately predict IP and EA of liquid water, however with often
 conflicting results depending on the level of theory and the underlying water
 structures. In a recent study based on hybrid-non-self-consistent many-body
 perturbation theory (MBPT)
 Gaiduk et al...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667545/molecular-bases-of-sperm-thermotaxis-old-and-new-knowledges
#20
Luca De Toni, Savina Dipresa, Carlo Foresta, Andrea Garolla
Sperm thermotaxis, namely the temperature-oriented motility of sperm cells, is a key process involved in ejaculated sperm guidance towards the oocyte for fertilization pourposes. Since its discovery in 2003, many studies clarified the dynamic, the sensitivity and the overall weight of this process in the comprehensive context of fertilization. However, the identification of sperm thermosensor/s remained elusive until recently. The most recent cues about the molecular bases of the old known process of thermotaxis are here revised...
April 18, 2018: Protein and Peptide Letters
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