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https://www.readbyqxmd.com/read/29555345/rapid-response-to-an-emerging-infectious-disease-lessons-learned-from-development-of-a-synthetic-dna-vaccine-targeting-zika-virus
#1
Sagar B Kudchodkar, Hyeree Choi, Emma L Reuschel, Rianne Esquivel, Jackie Jin-Ah Kwon, Moonsup Jeong, Joel N Maslow, Charles C Reed, Scott White, J Joseph Kim, Gary P Kobinger, Pablo Tebas, David B Weiner, Kar Muthumani
Vaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and in some cases, effectively eradicated through the deployment of specific vaccines. However, efforts to develop effective vaccines against infectious pathogens such as influenza, HIV, dengue virus (DENV), chikungunya virus (CHIKV), Ebola virus, and Zika virus (ZIKV) have proven challenging. Zika virus is a mosquito-vectored flavivirus responsible for periodic outbreaks of disease in Africa, Southeast Asia, and the Pacific Islands dating back over 50 years...
March 16, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29552450/a-case-of-htlv-1-associated-adult-t-cell-lymphoma-presenting-with-cutaneous-lesions-and-tropical-spastic-paresis
#2
Purva V Sharma, Michael Witteman, Swethika Sundaravel, Tulisa Larocca, Yuanming Zhang, Harry Goldsztajn
Adult T cell lymphoma (ATL), is a peripheral T cell neoplasm associated with infection by human T-lymphotropic virus (HTLV). This is a case of a 28-year-old lady who presented with back pain for the past month and recent onset weakness in her lower extremities bilaterally. She has a history of T-cell lymphoma secondary to HTLV-1 under remission since 2014 and systemic lupus erythematosus complicated by lupus nephritis. On physical examination patient had hyper-reflexia in both knees, ankle clonus bilaterally and spasticity in both her lower extremities...
February 2018: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29540345/immune-related-adverse-events-for-anti-pd-1-and-anti-pd-l1-drugs-systematic-review-and-meta-analysis
#3
REVIEW
Shrujal Baxi, Annie Yang, Renee L Gennarelli, Niloufer Khan, Ziwei Wang, Lindsay Boyce, Deborah Korenstein
OBJECTIVE: To evaluate rates of serious organ specific immune-related adverse events, general adverse events related to immune activation, and adverse events consistent with musculoskeletal problems for anti-programmed cell death 1 (PD-1) drugs overall and compared with control treatments. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Medline, Embase, Cochrane Library, Web of Science, and Scopus searched to 16 March 2017 and combined with data from ClinicalTrials...
March 14, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29520857/pityriasis-rosea-like-eruption-associated-with-ondansetron-use-in-pregnancy
#4
Malak M Alame, Dina J Chamsy, Hassan Zaraket
A 30-year-old pregnant female presented with a 2-week history of pityriasis rosea-like eruption. The rash started 2 days after the patient had started taking ondansetron 8 mg for alleviation of moderate-to-severe nausea and vomiting of pregnancy. Physical examination revealed erythematous papulosquamous lesions characterized by annular scaly margins and a dusky centre over the arms, chest, abdomen, lower back and legs. The rash did not involve the palms, sole or mucous membranes, and no lesions were observed on the lymph nodes...
March 9, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29512289/disseminated-blastomycosis-in-a-transplant-patient
#5
Douglas Challener, Omar Abu Saleh
A 51-year-old woman from Wisconsin with past medical history of kidney transplantation from her sibling 8 weeks prior, presented with symptoms of shortness of breath, cough and a new skin rash over a 2-week period. She has just finished a 10-day course of levofloxacin for pneumonia without improvement. On presentation she was afebrile and her exam was remarkable for few discrete pustular lesions over the face, back and the soles (Figure 1). This article is protected by copyright. All rights reserved.
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29469794/inflamed-actinic-keratoses-associated-with-pemetrexed-and-carboplatin-therapy
#6
Jimmy Lam, Samantha R Ellis, Raja K Sivamani
Eruptive actinic keratosis (AK) consequent to systemic chemotherapy can be confused with drug allergies. We present the first case of inflamed AKs in one patient after receiving combination therapy with pemetrexed and carboplatin.A 68-year-old woman with non-small cell lung adenocarcinoma (NSCLC) presented with numerous pruritic ill-defined, gritty, erythematous papules consistent with AKs on her upper chest, upper back, and arms two weeks after completing the first cycle of combination therapy with carboplatin and pemetrexed...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468405/efficacy-and-safety-of-ripasudil-a-rho-associated-kinase-inhibitor-in-eyes-with-uveitic-glaucoma
#7
Sentaro Kusuhara, Atsuko Katsuyama, Wataru Matsumiya, Makoto Nakamura
PURPOSE: The purpose of this study was to describe the initial experience, efficacy, and safety of ripasudil hydrochloride hydrate (ripasudil), a Rho-associated kinase inhibitor eye drop, for uveitic glaucoma. METHODS: In this retrospective case series, we retrieved the clinical data of 21 eyes from 19 patients with open-angle uveitic glaucoma who were treated with ripasudil at Kobe University Hospital. We analyzed the median intraocular pressure (IOP) reductions after ripasudil treatment and collected the information on the adverse events that were encountered during the course of this treatment period...
February 21, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29461579/gammal-imitat%C3%A3-r-g%C3%A3-r-comeback-t%C3%A3-nk-p%C3%A3-syfilis-vid-oklar-feber-sv%C3%A3-rbed%C3%A3-mda-exantem-och-sv%C3%A3-rf%C3%A3-rklarade-allm%C3%A3-nsymtom
#8
Eva Björnelius, Britta Krynitz
Syphilis - an old imitator is back on the stage Syphilis is one of the oldest sexually transmitted infections and caused by the spirochete Treponema pallidum. The incubation time is 10-90 days and patients are contagious for approximately one year. In Sweden all blood donors and pregnant women are screened. By law, individuals with early syphilis (primary and secondary stages) are reported and contact tracing is performed. The syphilis incidence is increasing in Europe, USA and many other countries. The main drivers are men having sex with men...
February 15, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29457211/acetarsol-suppositories-effective-treatment-for-refractory-proctitis-in-a-cohort-of-patients-with-inflammatory-bowel-disease
#9
Christopher J Kiely, Angela Clark, Joya Bhattacharyya, Gordon W Moran, James C Lee, Miles Parkes
BACKGROUND: Management of proctitis refractory to conventional therapies presents a common clinical problem. The use of acetarsol suppositories, which are derived from organic arsenic, was first described in 1965. Data concerning clinical efficacy and tolerability are very limited. AIM: To examine the efficacy of acetarsol suppositories for the treatment of refractory proctitis. METHODS: A retrospective analysis was performed on patients with inflammatory bowel disease treated with acetarsol suppositories between 2008 and 2014 at Addenbrooke's Hospital, Cambridge, United Kingdom...
February 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29386499/-a-case-of-lyme-neuroborreliosis-without-erythema-migrans
#10
Katsuki Eguchi, Kazuhumi Tsuzaka, Ichiro Yabe, Hidenao Sasaki
A 56-year-old man was sustained ticks at the left axilla and flank. He did not have a rash. About 3 months after the tick bites, he developed back pain, right leg weakness, right abducens nerve palsy, and left facial palsy. Western blot analysis for serum IgM and IgG antibodies against Borrelia were positive. We diagnosed Lyme borreliosis. The patient was treated with antibiotics and steroids, and the symptoms improved. Our findings demonstrate that, even if erythema migrans is not obvious, neuroborreliosis should be considered when neurological signs, such as multiple cranial nerve palsies, are present...
January 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29352346/the-evolution-of-breast-reduction-publications-a-bibliometric-analysis
#11
Ümran Muslu
OBJECTIVE: This study aims to make a bibliometric analysis of the studies on breast reduction (BR) between the years 1980 and 2016 and identify important studies through trend topics as well as active authors, countries, universities, scientific journals, and citation and co-citation analyses about BR. BACKGROUND: Although BR looks like one of the cosmetic surgeries performed in order to restore the woman's appearance, in fact it is a reconstructive surgery that eliminates back pain, stance disorder, headache, shoulder pain, back and cervical disk hernia, difficulty in breathing, hollowness caused by bra straps, hygiene problems under breasts (e...
January 19, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29348123/rash-associated-with-rivaroxaban-use
#12
Kelly M Rudd, Narmadha Panneerselvam, Anush Patel
PURPOSE: A case of a patient who developed a hypersensitivity reaction to rivaroxaban in the form of a diffuse, exanthematous rash is reported. SUMMARY: After starting rivaroxaban for treatment of cancer-associated deep vein thrombosis (DVT) with pulmonary embolism (PE), a 69-year-old Caucasian woman arrived at an oncology clinic with a diffuse, exanthematous (morbilliform) rash on her neck and torso, spreading to her upper and lower extremities. She reported that the symptoms started to develop about 48 hours after transitioning from subcutaneous enoxaparin to oral rivaroxaban...
March 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29168210/abrupt-generalized-pustules-in-patients-with-rheumatoid-arthritis-and-interstitial-lung-disease
#13
Wei Deng, Chaoyang Miao, Xiaoyan Zhang
We report a case of a 30-year-old Chinese woman with rheumatoid arthritis and interstitial lung disease who abruptly developed generalized pustules and a high fever for 10 days. She had been taking oral prednisone, iguratimod and total glucosides of peony regularly for 5 months prior. In addition, she had taken metronidazole for 3 days 20 days prior which she had used before with no adverse reaction. She had no history of similar lesions and psoriasis. A biopsy of a pustule on the back showed spongiform pustule of Kogoj...
November 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29107260/back-to-basics-environmental-cleaning-hazards
#14
Lisa Spruce
Perioperative personnel must clean and disinfect the perioperative environment numerous times throughout the day to help prevent the risk of exposing patients to pathogenic microorganisms. However, this practice exposes perioperative team members to chemicals that could be harmful to their health. Exposure to cleaning and disinfecting products has been associated with potential health problems such as skin irritation, burns, rashes, and difficulty breathing. This Back to Basics article offers strategies for perioperative team members to implement to decrease their risk of harmful exposure to these products...
November 2017: AORN Journal
https://www.readbyqxmd.com/read/29099518/diffuse-skin-rash-altered-mental-status-%C3%A2-dx
#15
Caitlyn T Reed, Allison R Cruse, Jeremy D Jackson
A 74-YEAR-OLD CAUCASIAN MAN presented to the hospital with intractable back and chest pain, a diffuse skin rash, and altered mental status. He said that 2 days ago, he'd gone to a different local hospital for treatment of back pain and a headache that had begun 3 days earlier. He was treated with intravenous hydromorphone and sent home with a prescription for meperidine. He said that several hours after being treated with the hydromorphone, the rash developed on his head and then spread to his trunk and upper extremities...
November 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/29070967/-case-report-glatiramer-acetate-induced-serum-sickness
#16
Paul Ferguson
Multiple sclerosis (MS) is a central nervous system demyelinating disease with a prevalence of approximately 400,000 individuals in the United States. Glatiramer acetate is a frequently prescribed disease-modifying therapy used for the management of relapsing forms of the disease. A 40-year-old woman with relapsing-remitting MS presented with symptomatic concerns of vomiting, fever, diffuse rash, joint and low back pain, and distal lower-limb paresthesia and was subsequently admitted to the hospital for investigation and treatment...
September 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28925642/a-persistent-rash-on-the-back-chest-and-abdomen
#17
Derek D Kane, Malia Grosskreutz
No abstract text is available yet for this article.
September 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28912408/-results-of-a-drug-use-survey-of-filgrastim-biosimilar-1-filgrastim-bs-syringe-for-inj-mochida-and-f
#18
Tsukasa Teshima, Nao Takigawa, Yuki Makita, Chinatsu Kushiya
With the aim of evaluating the safety and efficacy of filgrastim biosimilar 1(Filgrastim BS syringe for Inj. "MOCHIDA"and "F"), we conducted a drug use results survey of this product for its indications, including mobilization of hematopoietic stem cells into peripheral blood and chemotherapy-induced neutropenia. Of the 518 cases enrolled between August 2013 and July 2015, 495 were selected to be subjects of our safety and efficacy evaluations. 37 cases (7.47%)experienced side effects, which were mainly lower back pain(19, 3...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28881419/a-55-year-old-male-presenting-with-altered-mental-status-a-complicated-case-of-intracranial-aneurysm
#19
Shivani Garg, Arezou Khosroshahi
No abstract text is available yet for this article.
December 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28707716/paraneoplastic-systemic-lupus-erythematosus-in-association-with-oat-cell-tumour-of-the-lung
#20
LETTER
Y Mostmans, M Grosber, A De Coninck, V Peeters, J Ring, J Gutermuth
No abstract text is available yet for this article.
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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