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https://www.readbyqxmd.com/read/29166669/frequency-of-five-disease-causing-genetic-mutations-in-a-large-mixed-breed-dog-population-2011-2012
#1
Sharon Zierath, Angela M Hughes, Neale Fretwell, Mark Dibley, Kari J Ekenstedt
BACKGROUND: A large and growing number of inherited genetic disease mutations are now known in the dog. Frequencies of these mutations are typically examined within the breed of discovery, possibly in related breeds, but nearly always in purebred dogs. No report to date has examined the frequencies of specific genetic disease mutations in a large population of mixed-breed dogs. Further, veterinarians and dog owners typically dismiss inherited/genetic diseases as possibilities for health problems in mixed-breed dogs, assuming hybrid vigor will guarantee that single-gene disease mutations are not a cause for concern...
2017: PloS One
https://www.readbyqxmd.com/read/29166547/chemical-metabolome-assay-by-high-resolution-orbitrap-mass-spectrometry-and-assessment-of-associated-antitumoral-activity-of-actinocephalus-divaricatus
#2
Ana C Zanatta, Angela Mari, Milena Masullo, Iracilda Zeppone Carlos, Wagner Vilegas, Sonia Piacente, Lourdes Campaner Dos Santos
RATIONALE: Actinocephalus divaricatus (Eriocaulaceae) is an important source of income for the rural communities as it is sold as an ornamental plant. To date, no investigation has been conducted concerning the chemical composition and biological studies of the aerial parts of A. divaricatus. METHODS: The methanolic extract of the aerial parts of this species was chemically characterized. We applied an analytical dereplication approach based on Liquid Chromatography coupled to High Resolution Orbitrap Mass Spectrometry in order to develop, identify and define rapidly the metabolite fingerprint of the aerial parts of A...
November 22, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29166516/proteus-syndrome
#3
Ritha de Cássia Capelato Rocha, Mariani Paulino Soriano Estrella, Danielle Mechereffe do Amaral, Angela Marques Barbosa, Marilda Aparecida Milanez Morgado de Abreu
Proteus syndrome is a rare syndrome characterized by disproportionate overgrowth of limbs, multiple hamartomas, and vascular malformations. The cerebriform connective tissue nevi, also called cerebriform plantar hyperplasia, are present in most patients, and is the main characteristic of the syndrome. If present, even alone, they can be considered as a pathognomonic sign. This article reports a classic case of Proteus syndrome in a 2-year-old male patient who began to show a discrete asymmetry of the right hemibody in relation to the left one after birth, which increased over the months...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166462/effects-of-an-alternating-work-shift-on-air-traffic-controllers-and-the-relationship-with-excessive-daytime-sleepiness-and-stress
#4
Ângela M Freitas, Mirna Wetters Portuguez, Thaís Russomano, Marcos de Freitas, Silvio Luis da Silva Silvello, Jaderson Costa da Costa
OBJECTIVE: To evaluate symptoms of stress and excessive daytime sleepiness (EDS) in air traffic control (ATC) officers in Brazil. METHODS: Fifty-two ATC officers participated, based at three air traffic control units, identified as A, B and C. Stress symptoms were assessed using the Lipp Inventory of Stress Symptoms for Adults, and EDS by the Epworth Sleepiness Scale. RESULTS: The sample mean age was 37 years, 76.9% of whom were male. Excessive daytime sleepiness was identified in 25% of the ATC officers, with 84...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166389/comparisons-of-management-practices-and-farm-design-on-australian-commercial-layer-and-meat-chicken-farms-cage-barn-and-free-range
#5
Angela Bullanday Scott, Mini Singh, Jenny-Ann Toribio, Marta Hernandez-Jover, Belinda Barnes, Kathryn Glass, Barbara Moloney, Amanda Lee, Peter Groves
There are few published studies describing the unique management practices, farm design and housing characteristics of commercial meat chicken and layer farms in Australia. In particular, there has been a large expansion of free range poultry production in Australia in recent years, but limited information about this enterprise exists. This study aimed to describe features of Australian commercial chicken farms, with particular interest in free range farms, by conducting on-farm interviews of 25 free range layer farms, nine cage layer farms, nine barn layer farms, six free range meat chicken farms and 15 barn meat chicken farms in the Sydney basin bioregion and South East Queensland...
2017: PloS One
https://www.readbyqxmd.com/read/29166372/placental-lipid-processing-in-response-to-a-maternal-high-fat-diet-and-diabetes-in-rats
#6
Eli J Louwagie, Tricia D Larsen, Angela L Wachal, Michelle L Baack
BACKGROUND: Diabetes and obesity during pregnancy impact the health of both mothers and developing babies. Prevention focuses on glycemic control, but increasing evidence implicates a role for lipids. Using a rat model, we showed that a maternal high-fat (HF) diet, increased perinatal morbidity and mortality, but lipid processing across the maternal-placental-fetal triad remained unstudied. We hypothesized that HF diet would disrupt placental lipid processing to exaggerate fuel-mediated consequences of diabetic pregnancy...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166033/mapping-nanoscale-hotspots-with-single-molecule-emitters-assembled-into-plasmonic-nanocavities-using-dna-origami
#7
Rohit Chikkaraddy, V A Turek, Nuttawut Kongsuwan, Felix Benz, Cloudy Carnegie, Tim Van De Goor, Bart de Nijs, Angela Demetriadou, Ortwin Hess, Ulrich F Keyser, Jeremy J Baumberg
Fabricating nanocavities in which optically-active single quantum emitters are precisely positioned, is crucial for building nanophotonic devices. Here we show that self-assembly based on robust DNA-origami constructs can precisely position single molecules laterally within sub-5nm gaps between plasmonic substrates that support intense optical confinement. By placing single-molecules at the center of a nanocavity, we show modulation of the plasmon cavity resonance before and after bleaching the chromophore, and obtain enhancements of ≥ 4×10(3) with high quantum yield (≥ 50%)...
November 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/29165596/molecular-relatedness-of-esbl-ampc-producing-escherichia-coli-from-humans-animals-food-and-the-environment-a-pooled-analysis
#8
Alejandro Dorado-García, Joost H Smid, Wilfrid van Pelt, Marc J M Bonten, Ad C Fluit, Gerrita van den Bunt, Jaap A Wagenaar, Joost Hordijk, Cindy M Dierikx, Kees T Veldman, Aline de Koeijer, Wietske Dohmen, Heike Schmitt, Apostolos Liakopoulos, Ewa Pacholewicz, Theo J G M Lam, Annet G Velthuis, Annet Heuvelink, Maaike A Gonggrijp, Engeline van Duijkeren, Angela H A M van Hoek, Ana Maria de Roda Husman, Hetty Blaak, Arie H Havelaar, Dik J Mevius, Dick J J Heederik
Background: In recent years, ESBL/AmpC-producing Escherichia coli (ESBL/AmpC-EC) have been isolated with increasing frequency from animals, food, environmental sources and humans. With incomplete and scattered evidence, the contribution to the human carriage burden from these reservoirs remains unclear. Objectives: To quantify molecular similarities between different reservoirs as a first step towards risk attribution. Methods: Pooled data on ESBL/AmpC-EC isolates were recovered from 35 studies in the Netherlands comprising >27 000 samples, mostly obtained between 2005 and 2015...
November 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29165457/the-chemical-composition-nutritional-value-and-antimicrobial-properties-of-abelmoschus-esculentus-seeds
#9
Spyridon Petropoulos, Ângela Fernandes, Lillian Barros, Ana Ciric, Marina Sokovic, Isabel C F R Ferreira
Okra is a vegetable crop usually used for its immature pods. The harvest stage (fruit size) depends on consumers' preferences and the fruit that does not meet market requirements is being disposed of. Considering the short time interval from the setting of the fruit to the harvest stage, the present study evaluates the nutritional value, chemical composition, and antioxidant and antimicrobial properties of okra seeds from genotypes cultivated under Mediterranean conditions, as an alternative end-use product...
November 22, 2017: Food & Function
https://www.readbyqxmd.com/read/29165214/fecal-contamination-on-produce-from-wholesale-and-retail-food-markets-in-dhaka-bangladesh
#10
Angela R Harris, Mohammad Aminul Islam, Leanne Unicomb, Alexandria B Boehm, Stephen Luby, Jennifer Davis, Amy J Pickering
Fresh produce items can become contaminated with enteric pathogens along the supply chain at the preharvest (e.g., irrigation water, soil, fertilizer) or postharvest (e.g., vendor handling or consumer handling) stages. This study assesses the concentrations of fecal indicator bacteria Escherichia coli, enterococci (ENT), and Bacteriodales on surfaces of carrots, eggplants, red amaranth leaves, and tomatoes obtained from both a wholesale market (recently harvested) and neighborhood retail markets in Dhaka, Bangladesh...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165098/effects-of-olive-oil-on-tnf-%C3%AE-and-il-6-in-humans-implication-in-obesity-and-frailty
#11
Nagendra Sastry Yarla, Angela Polito, Ilaria Peluso
BACKGROUND AND OBJECTIVE: Tumor necrosis factor-alpha (TNF)-α and interleukin (IL)-6 are important mediators of chronic low-grade systemic inflammation. The latter plays a central role in several obesity-related pathologies, such as diabetes, metabolic syndrome and cardiovascular diseases. Besides, these cytokines have been also implicated in geriatric and cancer-induced anorexia, cachexia, sarcopenia and frailty. Potential interventions for both obesity and frailty include dietary advice and nutraceuticals...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29164443/child-autism-spectrum-disorder-traits-and-parenting-stress-the-utility-of-using-a-physiological-measure-of-parental-stress
#12
Reina S Factor, Deanna M Swain, Angela Scarpa
Caregivers of children with autism spectrum disorder (ASD) report greater stress due to unique parenting demands (e.g.; Estes et al. in Brain Dev 35(2):133-138, 2013). Stress is often studied through self-report and has not been extensively studied using physiological measures. This study compared parenting stress in mothers of children with and without ASD traits. Twenty-seven mother-child dyads participated in an interaction task while measuring mother's heart rate variability (HRV) and mothers self-reported stress levels...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164301/changes-in-multimodality-functional-imaging-parameters-early-during-chemoradiation-predict-treatment-response-in-patients-with-locally-advanced-head-and-neck-cancer
#13
Kee H Wong, Rafal Panek, Alex Dunlop, Dualta Mcquaid, Angela Riddell, Liam C Welsh, Iain Murray, Dow-Mu Koh, Martin O Leach, Shreerang A Bhide, Christopher M Nutting, Wim J Oyen, Kevin J Harrington, Kate L Newbold
OBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC). METHODS: Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent (18)F-FDG-PET/CT, and diffusion-weighted (DW), dynamic contrast-enhanced (DCE) and susceptibility-weighted MRI at baseline, week 1 and week 2 of chemoradiation...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29164086/a-novel-missense-mutation-of-the-nsd1-gene-associated-with-overgrowth-in-three-generations-of-an-italian-family-case-report-differential-diagnosis-and-review-of-mutations-of-nsd1-gene-in-familial-sotos-syndrome
#14
Gianluigi Laccetta, Francesca Moscuzza, Angela Michelucci, Andrea Guzzetta, Sara Lunardi, Francesca Lorenzoni, Paolo Ghirri
Sotos syndrome (SoS) is characterized by overgrowth of prenatal onset, learning disability, and characteristic facial appearance; it is usually due to haploinsufficiency of NSD1 gene at chromosome 5q35. An Italian child was born at 37 weeks of gestation (weight 2,910 g, 25th-50th centiles; length 50 cm, 75th centile; head circumference 36 cm, 97th centile) showing cryptorchidism on the right side, hypertelorism, dolichocephaly, broad and prominent forehead, and narrow jaw; the pregnancy was worsened by maternal preeclampsia and gestational diabetes, and his mother had a previous history of four early miscarriages...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29163848/radiation-therapy-and-serum-salivary-amylase-in-head-and-neck-cancer
#15
REVIEW
Francesca De Felice, Mario Tombolini, Angela Musella, Francesco Marampon, Vincenzo Tombolini, Daniela Musio
Radiation therapy (RT) is a valid treatment option for head and neck cancer (HNC). The risk of RT-induced toxicities is significant, especially due to extended treatment fields. The raise in amylase activity is strictly dependent on the volume of salivary glands included in the irradiated target volume and it is firmly related to the dose. The aim of this review is to report the effects on salivary amylase activity after radiation exposure of salivary glands, in patients with HNC.
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163728/results-of-a-quality-improvement-project-aimed-at-eliminating-healthcare-waste-by-changing-medical-resident-test-ordering-behavior
#16
Sushilkumar Satish Gupta, Radhika Voleti, Vimbai Nyemba, Selma Demir, Olaoluwatomi Lamikanra, Nomsa Musemwa, Angela Saverimuthu, Kamaldeen Agoro, Robert D Kalter, Peter Homel, Melvyn Hecht, Lawrence B Wolf, Edward K Chapnick, Michael G Kantrowitz, Stephan L Kamholz
Background: In light of rising healthcare costs and evidence of inefficient use of medical resources, there is growing interest in reducing healthcare waste by clinicians. Unwarranted lab tests may lead to further tests, prolonged hospital stays, unnecessary referrals and procedures, patient discomfort, and iatrogenic anemia, resulting in significant economic and clinical effects. Blood tests are essential in guiding medical decisions, but they are also associated with significant financial and clinical costs...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29163498/cytokine-profiles-of-severe-influenza-virus-related-complications-in-children
#17
Andrew Fiore-Gartland, Angela Panoskaltsis-Mortari, Anna A Agan, Anushay J Mistry, Paul G Thomas, Michael A Matthay, Tomer Hertz, Adrienne G Randolph
Rationale: Effective immunomodulatory therapies for children with life-threatening "cytokine storm" triggered by acute influenza infection are lacking. Understanding the immune profiles of children progressing to severe lung injury and/or septic shock could provide insight into pathogenesis. Objectives: To compare the endotracheal and serum cytokine profiles of children with influenza-related critical illness and to identify their associations with severe influenza-associated complications...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163162/a-randomized-double-blinded-clinical-trial-on-effects-of-a-vitis-vinifera-extract-on-cognitive-function-in-healthy-older-adults
#18
Gioacchino Calapai, Francesco Bonina, Andrea Bonina, Luisa Rizza, Carmen Mannucci, Vincenzo Arcoraci, Germana Laganà, Angela Alibrandi, Concetta Pollicino, Santi Inferrera, Umberto Alecci
Introduction: Gradual population aging is creating a new set of needs in the general population. Memory capacity decreases with age, and memory deficits are considered an early symptom of Alzheimer's Disease (AD), one of the most prevalent cognitive disorders in older people. Numerous studies have shown that grape polyphenolic compounds (GPs) are able to attenuate cognitive impairment and reduce brain lesions in experimental AD animal models. These GP effects are associated with improvement in brain antioxidant status and prevention of free radical-induced neuronal damage...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163035/npas2-regulation-of-anxiety-like-behavior-and-gabaa-receptors
#19
Angela R Ozburn, Joseph Kern, Puja K Parekh, Ryan W Logan, Zheng Liu, Edgardo Falcon, Darius Becker-Krail, Kush Purohit, Nicole M Edgar, Yanhua Huang, Colleen A McClung
Abnormal circadian rhythms and circadian genes are strongly associated with several psychiatric disorders. Neuronal PAS Domain Protein 2 (NPAS2) is a core component of the molecular clock that acts as a transcription factor and is highly expressed in reward- and stress-related brain regions such as the striatum. However, the mechanism by which NPAS2 is involved in mood-related behaviors is still unclear. We measured anxiety-like behaviors in mice with a global null mutation in Npas2 (Npas2 null mutant mice) and found that Npas2 null mutant mice exhibit less anxiety-like behavior than their wild-type (WT) littermates (in elevated plus maze, light/dark box and open field assay)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29162989/a-retrospective-study-on-the-outcomes-of-ahmed-valve-versus-ahmed-valve-combined-with-fluocinolone-implant-in-uveitic-glaucoma
#20
Duriye D Sevgi, Samaneh Davoudi, Katherine E Talcott, Heeyoon Cho, Rong Guo, Ann-Marie Lobo, George N Papaliodis, Angela Turalba, Lucia Sobrin, Lucy Q Shen
Purpose: To compare the intraocular pressure (IOP) outcomes of Ahmed glaucoma valve (AGV) surgery alone versus AGV with fluocinolone implant in uveitic glaucoma patients. Methods: We identified uveitic glaucoma patients with AGV surgery alone and AGV surgery combined with fluocinolone implant from the Massachusetts Eye and Ear Ocular Inflammation Database. Demographic information, visual acuity, and IOP were recorded at preoperative visits and 1, 6, and 12 months after surgery...
2017: Digital Journal of Ophthalmology: DJO
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