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https://www.readbyqxmd.com/read/28944985/ultrasound-characteristics-of-endometrial-cancer-as-defined-by-the-international-endometrial-tumor-analysis-ieta-consensus-nomenclature-a-prospective-multicenter-study
#1
Elisabeth Epstein, Daniela Fischerova, Lil Valentin, Antonia Carla Testa, Dorella Franchi, Povilas Sladkevicius, Frühauf Filip, Pelle G Lindqvist, Floriana Mascilini, Robert Fruscio, Lucia Anna Haak, Gina Opolskiene, Maria Angela Pascual, Juan Luis Alcazar, Valentina Chiappa, Stefano Guerriero, Joseph Carlson, Caroline Van Holsbeke, Francesco Paolo Giuseppe Leone, Bart De Moor, Tom Bourne, Ben van Calster, Arnaud Installe, Dirk Timmerman, Jan Y Verbakel, Thierry Van den Bosch
OBJECTIVES: To describe the sonographic features of endometrial cancer in relation to stage, grade, and histological type using the International Endometrial Tumor Analysis (IETA) terminology. METHODS: Prospective multicenter study on 1714 women with endometrial cancer undergoing a standardized transvaginal grayscale and Doppler ultrasound examination by an experienced ultrasound examiner using a high-end ultrasound system. Clinical and sonographic data were entered into a web-based protocol...
September 25, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28944270/the-role-of-leptin-in-health-and-disease
#2
REVIEW
Angela M Ramos-Lobo, Jose Donato
Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts important control on glucose homeostasis, thermogenesis, autonomic nervous system and neuroendocrine axes. In metabolic diseases, such as obesity and diabetes mellitus, leptin signaling may be compromised, indicating the important role of this hormone in the etiology and pathophysiological manifestations of these conditions. In the present manuscript, we reviewed important concepts of leptin signaling, as well as about the effects of leptin on several biologic functions...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28944238/targeted-sequencing-of-36-known-or-putative-colorectal-cancer-susceptibility-genes
#3
Melissa S DeRycke, Shanaka Gunawardena, Jessica R Balcom, Angela M Pickart, Lindsey A Waltman, Amy J French, Shannon McDonnell, Shaun M Riska, Zachary C Fogarty, Melissa C Larson, Sumit Middha, Bruce W Eckloff, Yan W Asmann, Matthew J Ferber, Robert W Haile, Steven Gallinger, Mark Clendenning, Christophe Rosty, Aung K Win, Daniel D Buchanan, John L Hopper, Polly A Newcomb, Loic Le Marchand, Ellen L Goode, Noralane M Lindor, Stephen N Thibodeau
BACKGROUND: Mutations in several genes predispose to colorectal cancer. Genetic testing for hereditary colorectal cancer syndromes was previously limited to single gene tests; thus, only a very limited number of genes were tested, and rarely those infrequently mutated in colorectal cancer. Next-generation sequencing technologies have made it possible to sequencing panels of genes known and suspected to influence colorectal cancer susceptibility. METHODS: Targeted sequencing of 36 known or putative CRC susceptibility genes was conducted for 1231 CRC cases from five subsets: (1) Familial Colorectal Cancer Type X (n = 153); (2) CRC unselected by tumor immunohistochemical or microsatellite stability testing (n = 548); (3) young onset (age <50 years) (n = 333); (4) proficient mismatch repair (MMR) in cases diagnosed at ≥50 years (n = 68); and (5) deficient MMR CRCs with no germline mutations in MLH1, MSH2, MSH6, or PMS2 (n = 129)...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28943244/new-5-ht1a-5ht2a-and-5ht2c-receptor-ligands-containing-a-picolinic-nucleus-synthesis-in-vitro-and-in-vivo-pharmacological-evaluation
#4
Ferdinando Fiorino, Elisa Magli, Ewa Kędzierska, Antonio Ciano, Angela Corvino, Beatrice Severino, Elisa Perissutti, Francesco Frecentese, Paola Di Vaio, Irene Saccone, Angelo A Izzo, Raffaele Capasso, Paola Massarelli, Ilaria Rossi, Jolanta Orzelska-Gòrka, Jolanta Helena Kotlińska, Vincenzo Santagada, Giuseppe Caliendo
Picolinamide derivatives, linked to an arylpiperazine moiety, were prepared and their affinity to 5-HT1A, 5-HT2A and 5-HT2C receptors was evaluated. The combination of structural elements (heterocyclic nucleus, alkyl chain and 4-substituted piperazine), known to play critical roles in affinity for serotoninergic receptors, and the proper selection of substituents led to compounds with high specificity and affinity towards serotoninergic receptors. In binding studies, several molecules showed high affinity in nanomolar and subnanomolar range at 5-HT1A, 5-HT2A and 5-HT2C receptors and moderate or no affinity for other relevant receptors (D1, D2, α1 and α2)...
September 18, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28943242/csnk1a1-regulates-prmt1-to-maintain-the-progenitor-state-in-self-renewing-somatic-tissue
#5
Xiaomin Bao, Zurab Siprashvili, Brian J Zarnegar, Rajani M Shenoy, Eon J Rios, Natalie Nady, Kun Qu, Angela Mah, Daniel E Webster, Adam J Rubin, Glenn G Wozniak, Shiying Tao, Joanna Wysocka, Paul A Khavari
Somatic progenitors sustain tissue self-renewal while suppressing premature differentiation. Protein arginine methyltransferases (PRMTs) affect many processes; however, their role in progenitor function is incompletely understood. PRMT1 was found to be the most highly expressed PRMT in epidermal progenitors and the most downregulated PRMT during differentiation. In targeted mouse knockouts and in long-term regenerated human mosaic epidermis in vivo, epidermal PRMT1 loss abolished progenitor self-renewal and led to premature differentiation...
September 18, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28942203/potentially-inappropriate-medication-association-between-the-use-of-antidepressant-drugs-and-the-subsequent-risk-for-dementia
#6
Kathrin Heser, Tobias Luck, Susanne Röhr, Birgitt Wiese, Hanna Kaduszkiewicz, Anke Oey, Horst Bickel, Edelgard Mösch, Siegfried Weyerer, Jochen Werle, Christian Brettschneider, Hans-Helmut König, Angela Fuchs, Michael Pentzek, Hendrik van den Bussche, Martin Scherer, Wolfgang Maier, Steffi G Riedel-Heller, Michael Wagner
BACKGROUND: Potentially inappropriate medication (PIM) is associated with an increased risk for detrimental health outcomes in elderly patients. Some antidepressant drugs are considered as PIM, but previous research on the association between antidepressants and subsequent dementia has been inconclusive. Therefore, we investigated whether the intake of antidepressants, particularly of those considered as PIM according to the Priscus list, would predict incident dementia. METHODS: We used data of a prospective cohort study of non-demented primary care patients (n = 3239, mean age = 79...
September 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28941682/lc-ms-profiling-highlights-hazelnut-nocciola-di-giffoni-pgi-shells-as-a-byproduct-rich-in-antioxidant-phenolics
#7
Milena Masullo, Antonietta Cerulli, Angela Mari, Carla Clisiane de Souza Santos, Cosimo Pizza, Sonia Piacente
The Italian "Nocciola di Giffoni", also known as "Tonda di Giffoni", a labelled Protected Geographical Indication (PGI) product, represents an important economic resource for the Italian market. The methanol (MeOH) extract of "Tonda di Giffoni" shells has been investigated for the phenolic content, assayed by the Folin-Ciocalteu method, and for the antioxidant activity by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Trolox Equivalent Antioxidant Capacity (TEAC) assays. In order to achieve deeper insight into the chemical composition of the shells of hazelnut "Nocciola di Giffoni" and to highlight the occurrence of biologically active compounds, a phytochemical investigation was carried out...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28941311/endocrinopathies-with-use-of-cancer-immunotherapies
#8
Natalie M Villa, Abtin Farahmand, Lin Du, Michael W Yeh, Stephanie Smooke-Praw, Antoni Ribas, Bartosz Chmielowski, Grace Cherry, Angela M Leung
BACKGROUND: Immunomodulatory therapies, including CTLA-4 and PD-1 inhibitors, provide a directed attack against cancer cells by preventing T cell deactivation. However, these drugs also prevent the down-regulation of auto-reactive T cells, resulting in immune-related adverse events (IRAEs). Reports show a varied incidence of endocrine IRAEs, ranging from 0-63%. OBJECTIVE: To describe the frequency and clinical characteristics of endocrine IRAEs in patients taking cancer immunomodulatory therapies...
September 23, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28941204/diabetes-related-fatigue
#9
EDITORIAL
Angela Shin-Yu Lien, Jawl-Shan Hwang, Yi-Der Jiang
Frequent complaint of fatigue for people with chronic condition is a strong predictor for functional limitations, disability, increasing mortality, and other adverse outcomes. With a high prevalence of diabetes in older people worldwide, fatigue symptoms, including frailty, muscle weakness, impaired mobility, functional limitation and loss of independence, are usually complained. Fatigue symptoms accompanied by the complications of neuromuscular dysfunction due to poor glycemic control, cardiovascular disease or peripheral vascular deficit were commonly shown for people with diabetes [1]...
September 22, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28940848/executive-function-and-functional-and-structural-brain-differences-in-middle-age-adults-with-autism-spectrum-disorder
#10
B Blair Braden, Christopher J Smith, Amiee Thompson, Tyler K Glaspy, Emily Wood, Divya Vatsa, Angela E Abbott, Samuel C McGee, Leslie C Baxter
There is a rapidly growing group of aging adults with autism spectrum disorder (ASD) who may have unique needs, yet cognitive and brain function in older adults with ASD is understudied. We combined functional and structural neuroimaging and neuropsychological tests to examine differences between middle-aged men with ASD and matched neurotypical (NT) men. Participants (ASD, n = 16; NT, n = 17) aged 40-64 years were well-matched according to age, IQ (range: 83-131), and education (range: 9-20 years)...
September 21, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28940805/methods-for-delivering-the-uk-s-multi-centre-prison-based-naloxone-on-release-pilot-randomised-trial-n-alive-europe-s-largest-prison-based-randomised-controlled-trial
#11
Angela Mary Meade, Sheila Macdonald Bird, John Strang, Tracey Pepple, Laura Lea Nichols, Monica Mascarenhas, Louise Choo, Mahesh Kumar Bhikhubhai Parmar
INTRODUCTION AND AIMS: Naloxone is an opioid antagonist used for emergency resuscitation following opioid overdose. Prisoners with a history of heroin use by injection have a high risk of drug-related death in the first weeks after prison-release. The N-ALIVE trial was planned as a large prison-based randomised controlled trial (RCT) to test the effectiveness of naloxone-on-release in the prevention of fatal opiate overdoses soon after release. The N-ALIVE pilot trial was conducted to test the main trial's assumptions on recruitment of prisons and prisoners, and the logistics for ensuring that participants received their N-ALIVE pack on release...
September 21, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28940710/experiences-in-feeding-and-gastrointestinal-dysfunction-in-children-with-charge-syndrome
#12
Meghan Macdonald, Alexandra Hudson, Angela Bladon, Elyanne Ratcliffe, Kim Blake
Feeding issues are very common in individuals with CHARGE syndrome and can lead to increased morbidity and mortality. The aim of this study was to expand upon the limited knowledge base of feeding and gastrointestinal issues in individuals with CHARGE syndrome. Parents of individuals (age range 1-18 years) with CHARGE syndrome, with or without feeding/gastrointestinal issues, were recruited through international CHARGE syndrome associations and CHARGE syndrome Facebook pages. Parents completed three questionnaires: CHARGE diagnostic characteristics; Pediatric Assessment Scale for Severe Feeding Problems © and PedsQL™ Gastrointestinal Symptoms Scale; and open-ended questions...
September 22, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28940366/lon-protease-a-novel-mitochondrial-matrix-protein-in-the-interconnection-between-drug-induced-mitochondrial-dysfunction-and-er-stress
#13
Miriam Polo, Fernando Alegre, Angela B Moragrega, Lara Gibellini, Alberto Marti-Rodrigo, Ana Blas-Garcia, Juan V Esplugues, Nadezda Apostolova
BACKGROUND AND PURPOSE: Mitochondria-associated membranes (MAMs) are specific ER-domains that enable direct interaction with mitochondria and mediate metabolic flow and Ca(2+) transfer. A growing list of proteins have been identified as MAMs components, but how they are recruited and function during complex cell stress situations is still not understood while the participation of mitochondrial matrix proteins is largely undervalued. EXPERIMENTAL APPROACH: This work compares mitochondrial/ER contact during combined ER stress/mitochondrial dysfunction using a model of human hepatoma cells (Hep3B cell line) treated for 24h with classic pharmacological inducers of ER stress (thapsigargin), mitochondrial dysfunction (CCCP or rotenone) or both (the antiretroviral drug Efavirenz used at clinically relevant concentrations)...
September 23, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28940324/vividness-of-positive-mental-imagery-predicts-positive-emotional-response-to-visually-presented-project-soothe-pictures
#14
Alexander C Wilson, Matthias Schwannauer, Angela McLaughlin, Fiona Ashworth, Stella W Y Chan
Lang's bioinformational theory of mental imagery proposes that mental imagery and external stimuli engage emotional information-processing systems in similar ways. However, the positive and negative systems are thought to be distinct, so this similarity is likely to show a valence-specific effect. Therefore, we hypothesized that an individual's ability to construct vivid positive, but not negative, mental imagery would predict positive emotional responding to positive visual stimuli, independently of depressive symptoms...
September 20, 2017: British Journal of Psychology
https://www.readbyqxmd.com/read/28940123/short-term-antiretroviral-treatment-recommendations-based-on-sensitivity-analysis-of-a-mathematical-model-for-hiv-infection-of-formula-see-text-cells
#15
Ana-Maria Croicu, Angela M Jarrett, N G Cogan, M Yousuff Hussaini
HIV infection is one of the most difficult infections to control and manage. The most recent recommendations to control this infection vary according to the guidelines used (US, European, WHO) and are not patient-specific. Unfortunately, no two individuals respond to infection and treatment quite the same way. The purpose of this paper is to make use of the uncertainty and sensitivity analysis to investigate possible short-term treatment options that are patient-specific. We are able to identify the most significant parameters that are responsible for ART outcome and to formulate some insights into the ART success...
September 22, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28939965/complement-immune-evasion-by-spirochetes
#16
Angela S Barbosa, Lourdes Isaac
The complement system plays an important role in the innate and acquired immune response against pathogens. A sophisticated network of activating and regulating proteins allows the distinction between intact and damaged host and non-host surfaces such as bacteria and other parasites. Non-host structures trigger the alternative pathway which may lead to their elimination by phagocytosis or cell lysis. In addition, complement proteins such as C1q, mannose binding lectin (MBL), and ficolins act as pathogen pattern-recognition molecules...
September 23, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28939720/to-pretreat-or-not-to-pretreat-with-oral-p2y12-antagonists-that-is-the-question
#17
EDITORIAL
Angela Lowenstern, L Kristin Newby
No abstract text is available yet for this article.
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28939712/obesity-treatment-times-and-cardiovascular-outcomes-after-st-elevation-myocardial-infarction-findings-from-mission-lifeline-north-texas
#18
Tiffany Champagne-Langabeer, Junghyun Kim, Julie K Bower, Angela Gardner, Raymond Fowler, James R Langabeer
BACKGROUND: With increasing rates of obesity and its link with cardiovascular disease, there is a need for better understanding of the obesity-outcome relationship. This study explores the association between categories of obesity with treatment times and mortality for patients experiencing ST-segment elevation myocardial infarction. METHODS AND RESULTS: We examined 8725 patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention and used regression models to analyze the relationship between 6 categories of body mass index with key door-to-balloon time, total ischemic time, and in-hospital mortality...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28939455/neurocognitive-dysfunction-in-hematopoietic-cell-transplant-recipients-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-complications-and-quality-of-life-working-party-of-the-ebmt
#19
REVIEW
Debra Lynch Kelly, David Buchbinder, Rafael F Duarte, Jeffrey J Auletta, Neel Bhatt, Michael Byrne, Melissa Gabriel, Anuj Mahindra, Maxim Norkin, Helene Schoemans, Ami J Shah, Ibrahim Ahmed, Yoshiko Atsuta, Grzegorz W Basak, Sara Beattie, Sita Bhella, Christopher Bredeson, Nancy Bunin, Jignesh Dalal, Andrew Daly, James Gajewski, Robert Peter Gale, John Galvin, Mehdi Hamadani, Robert J Hayashi, Kehinde Adekola, Jason Law, Catherine J Lee, Jane Liesveld, Adriana K Malone, Arnon Nagler, Seema Naik, Taiga Nishihori, Susan K Parsons, Angela Scherwath, Hannah-Lise Schofield, Robert Soiffer, Jeff Szer, Ida Twist, Anne Warwick, Baldeep M Wirk, Jean Yi, Minoo Battiwalla, Mary E Flowers, Bipin Savani, Bronwen E Shaw
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT...
September 19, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28939440/staphylococcus-epidermidis-is-largely-dependent-on-iron-availability-to-form-biofilms
#20
Fernando Oliveira, Ângela França, Nuno Cerca
Staphylococcus epidermidis has long been known as a major bacterial coloniser of the human skin, yet it is also a prominent nosocomial pathogen. Its remarkable ability to assemble structured biofilms has been its major known pathogenic feature to date. Notwithstanding important discoveries that have been accomplished, several questions about S. epidermidis biofilm formation still remain to be elucidated. This study aimed to assess whether iron availability modulates S. epidermidis biofilm formation and, if so, to explore how such modulation occurs...
September 19, 2017: International Journal of Medical Microbiology: IJMM
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