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cleft palate and lip

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https://www.readbyqxmd.com/read/29466515/individual-deprivation-regional-deprivation-and-risk-for-oral-clefts-in-argentina
#1
Mariela Soledad Pawluk, Hebe Campaña, Monica Rittler, Fernando Adrián Poletta, Viviana R Cosentino, Juan Antonio Gili, Lucas Gabriel Gimenez, Jorge Santiago López Camelo
OBJECTIVE: The aim of this study was to analyze the effects of individual low socioeconomic status (SES) and deprived geographical area (GA) on the occurrence of isolated cleft lip with or without cleft palate (CL±P) in Argentina. METHODS: This case-control study included 577 newborns with isolated CL±P and 13 344 healthy controls, born between 1992 and 2001, from a total population of 546 129 births in 39 hospitals in Argentina. Census data on unsatisfied basic needs were used to establish the degree of geographical area deprivation...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/29465075/-resorbable-vs-nonresorbable-fixation-in-alveolar-bone-grafting-in-unilateral-cleft-lip-and-palate-patients
#2
A L Ivanov, E I Reshetnyak, N V Starikova, N V Udalova, A G Nadtochy
The aim of the study was to evaluate the resorbable vs nonresorbable fixation efficiency in bone grafting for unilateral cleft lip and palate (UCLP) patients. Thirty eight UCLP patients aged from 7 to 17 years (mean 11.5±3.1 years) were divided in two groups with different types of cortical graft fixation: group 1 ─ titanium screws (22 patients), group 2 ─ resorbable pins (16 patients). The Bergland and Chelsea scales were used to evaluate the outcomes 8 months after surgery. Additional authors' original scales were introduced: bone volume scale and pyriform rim restoration scale...
2018: Stomatologii︠a︡
https://www.readbyqxmd.com/read/29465048/evaluation-of-teeth-development-in-unilateral-cleft-lip-and-palate-patients-in-mixed-dentition-by-using-medical-image-control-systems
#3
O Gezgin, M S Botsali
Objectives: The aim of this study was to evaluate the crown and root development in patients with cleft lip and palate using medical software programmes. Materials and Methods: In our study, 25 patients with mixed dentition unilateral cleft lip and palate were examined with cone-beam computed tomography (CBCT). The tomography images obtained as high resolution medical images on the computer control system (MIMICS 15.0, Materialise, Leuven, Belgium and SOLIDWORKS 2014 Premium, Concord, Massachusetts) were converted to three-dimensional volumetric images...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29461877/active-presurgical-infant-orthopedics-for-unilateral-cleft-lip-and-palate-intercenter-outcome-comparison-of-latham-modified-mcneil-and-nasoalveolar-molding
#4
Michelle Kornbluth, Richard E Campbell, John Daskalogiannakis, Elizabeth J Ross, Patricia H Glick, Kathleen A Russell, Jean-Charles Doucet, Ronald R Hathaway, Ross E Long, Thomas J Sitzman
OBJECTIVE: To compare dental arch relationship, craniofacial form, and nasolabial aesthetic outcomes among cleft centers using distinct methods of presurgical infant orthopedics (PSIO). DESIGN: Retrospective cohort study. SETTING: Four cleft centers in North America. PATIENTS: One hundred ninety-one children with repaired complete unilateral cleft lip and palate (CUCLP). MAIN OUTCOME MEASURES: Dental arch relationship was assessed using the GOSLON Yardstick...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29461876/voice-quality-in-adults-treated-for-unilateral-cleft-lip-and-palate-long-term-follow-up-after-1-or-2-stage-palate-repair
#5
Staffan Morén, Per Åke Lindestad, Mats Holmström, Maria Mani
OBJECTIVES: The aim of the current study was to assess voice quality among adults treated for unilateral cleft lip and palate (UCLP), after 1- or 2-stage palate closure, and compare it to a noncleft control group. STUDY DESIGN: Cross-sectional study in UCLP patients with long-term follow-up and noncleft controls. PARTICIPANTS: UCLP patients born 1960-1987, treated at Uppsala University Hospital, Sweden, were examined (n = 73) at a mean of 35 years after primary surgery...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29461539/-improving-care-for-cleft-lip-and-palate-patients-uniform-and-patient-orientated-outcome-measures
#6
M Haj, H H W de Gier, M van Veen-van der Hoek, S L Versnel, L N van Adrichem, E B Wolvius, J A Hazelzet, M J Koudstaal
The quality of care for patients with cleft lip and palate is extremely variable across the world. Treatment protocols differ and methods of data registration are not uniform. Improving this care by means of comparative research is challenging. The best treatment programmes can be identified by uniformly registering patient-orientated outcomes and comparing the outcomes with those of other treatment centres. That knowledge can be used to improve one's own care. An international team consisting of specialists and cleft lip and palate patients has developed a set of outcome measures that are considered by patients to be most important...
February 2018: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29461366/long-term-skeletal-changes-after-maxillary-distraction-osteogenesis-in-growing-children-with-cleft-lip-palate
#7
Kai Liu, Nuo Zhou
PURPOSE: To systematically evaluate the skeletal changes after maxillary distraction osteogenesis (DO) in growing patients with cleft lip with or without cleft palate (CL/P). MATERIALS AND METHODS: Electronic databases, gray literature, and reference list searches were conducted. Articles reporting prospective and retrospective studies that included patients <16 years old (N ≥ 6) who had received DO surgery for correction of a midfacial hypoplasia due to CL/P, and the period of follow-up persisted >1 year were reviewed...
February 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29460382/an-algorithm-for-predicting-robin-sequence-from-fetal-mri
#8
Cory M Resnick, Tessa D Kooiman, Carly E Calabrese, David Zurakowski, Bonnie L Padwa, Maarten J Koudstaal, Judy A Estroff
BACKGROUND: Infants with Robin sequence (RS) may present with airway compromise at delivery. Prenatal diagnosis would improve preparation and postnatal care. The purpose of this study was to devise a predictive algorithm for RS based on fetal magnetic resonance imaging (MRI). METHODS: Retrospective case-control study including fetal MRIs from 2002-2017. Inclusion criteria were: (1) MRI of adequate quality, (2) live-born infant, and (3) postnatal evaluation. Subjects were grouped based on postnatal diagnosis: (1) RS (micrognathia, glossoptosis, airway obstruction), (2) micrognathia without airway obstruction ("micrognathia"), (3) cleft lip and palate ("CLP"), and (4) gestational-age-matched controls...
February 19, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29457660/prevalence-of-orofacial-clefts-and-risks-for-nonsyndromic-cleft-lip-with-or-without-cleft-palate-in-newborns-at-a-university-hospital-from-west-mexico
#9
Jorge Román Corona-Rivera, Lucina Bobadilla-Morales, Alfredo Corona-Rivera, Christian Peña-Padilla, Sandra Olvera-Molina, Miriam A Orozco-Martín, Diana García-Cruz, Izabel M Ríos-Flores, Brian Gabriel Gómez-Rodríguez, Gemma Rivas-Soto, J Jesús Pérez-Molina
We determined the overall prevalence of typical orofacial clefts (OFCs) and the potential risks for nonsyndromic cleft lip with or without palate (NSCL±P) in a University Hospital from west México. For the prevalence, 227 live born infants with typical OFCs were included from a total of 81,193 births occurred during the period 2009 to 2016 at the 'Dr. Juan I. Menchaca' Civil Hospital of Guadalajara (Guadalajara, Jalisco, Mexico). To evaluate potential risks, a case-control study was conducted among 420 newborns, including only those 105 patients with NSCL±P (cases), and 315 infants without birth defects (controls)...
February 19, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29457596/evaluation-of-osteoinductive-calcium-phosphate-ceramics-repairing-alveolar-cleft-defects-in-dog-model
#10
Jinfeng Yao, Haodong Chen, Qi Gao, Zhigang Liang
BACKGROUND: Alveolar cleft repair is an important step in the sequence of treatments for cleft lip and palate. Intrinsically osteoinductive materials have been the subject of research interest. OBJECTIVE: The aim of this study was to explore the use of osteoinductive biphasic calcium phosphate (BCP) ceramics to repair alveolar cleft defects in dogs. METHODS: We prepared two kinds of BCP ceramic with different physical characteristics: osteoinductive BCP (OBCP) and non-osteoinductive BCP (NBCP)...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29456483/two-novel-pathogenic-mid1-variants-and-genotype-phenotype-correlation-reanalysis-in-x-linked-opitz-g-bbb-syndrome
#11
Nuno Maia, Maria J Nabais Sá, Nataliya Tkachenko, Gabriela Soares, Isabel Marques, Bárbara Rodrigues, Ana M Fortuna, Rosário Santos, Arjan P M de Brouwer, Paula Jorge
X-linked Opitz G/BBB syndrome (XLOS) is a multisystemic congenital condition, caused by mutations in the midline-1 gene ( MID1 ), characterized by a large inter- and intrafamilial phenotypic variability and often associated with intellectual disability (ID). We report clinical, genetic, and molecular findings in 4 patients with typical XLOS dysmorphic features belonging to 2 unrelated families. Two novel pathogenic loss-of-function MID1 variants, a maternally inherited c.1656del and a de novo c.1215_1228dup, were identified...
December 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/29452576/assessing-retention-in-care-after-12-months-of-the-pediatric-development-clinic-implementation-in-rural-rwanda-a-retrospective-cohort-study
#12
Scheilla Bayitondere, Francois Biziyaremye, Catherine M Kirk, Hema Magge, Katrina Hann, Kim Wilson, Christine Mutaganzwa, Eric Ngabireyimana, Fulgence Nkikabahizi, Evelyne Shema, David B Tugizimana, Ann C Miller
BACKGROUND: In Africa, a high proportion of children are at risk for developmental delay. Early interventions are known to improve outcomes, but they are not routinely available. The Rwandan Ministry of Health with Partners In Health/Inshuti Mu Buzima created the Pediatric Development Clinic (PDC) model for providing interdisciplinary developmental care for high-risk infants in rural settings. As retention for chronic care has proven challenging in many settings, this study assesses factors related to retention to care after 12 months of clinic enrollment...
February 16, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29450693/the-effect-of-assisted-reproductive-technology-on-the-incidence-of-birth-defects-among-livebirths
#13
Gil Shechter-Maor, Nicholas Czuzoj-Shulman, Andrea R Spence, Haim Arie Abenhaim
PURPOSE: Our study objective is to examine the association between births conceived with assisted reproductive technology (ART) and birth defects using a large database from the United States. METHODS: Using the Centers for Disease Control and Prevention's Period-linked birth-infant death data files and fetal death database for 2011-2013, we conducted a retrospective cohort study comprised of live births that occurred in the USA during that time. Multivariate logistic regression was used to estimate the association between ART and birth defects, both overall and by specific defects...
February 15, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29446986/an-intercenter-comparison-of-nasolabial-appearance-including-a-center-using-nasoalveolar-molding
#14
Supakit Peanchitlertkajorn, Ana Mercado, John Daskalogiannakis, Ronald Hathaway, Kathleen Russell, Gunvor Semb, William Shaw, Manish Lamichane, Marilyn Cohen, Ross E Long
OBJECTIVE: To compare nasolabial appearance outcomes of patients with complete unilateral cleft lip and palate (CUCLP) in preadolescence from 4 cleft centers including a center using nasoalveolar molding (NAM) and primary nasal reconstruction. DESIGN: Retrospective cohort study. SETTING: Four cleft centers in North America. PATIENTS: 135 subjects with repaired CUCLP. METHODS: Frontal and profile facial pictures were assessed using the Asher-McDade rating scale...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29446255/potential-genetic-markers-for-nonsyndromic-oral-clefts-in-the-brazilian-population-a-systematic-review-and-meta-analysis
#15
REVIEW
Renato Assis Machado, Isabela Porto de Toledo, Hercilio Martelli-Júnior, Silvia Regina Reis, Eliete Neves Silva Guerra, Ricardo D Coletta
BACKGROUND: Although various genes and genomic regions were described as of susceptibility for nonsyndromic oral clefts (NOC), recent reports have demonstrated significant interethnic variations in the genetic predisposition, a situation that affects the Brazilian population, one of the most admixed populations in the world. Therefore, the purpose of this review was to describe the available information on genetic risk markers for NOC in the Brazilian population. METHODS: A systematic search of the literature was performed using LILACS, LIVIVO, PubMed, Scopus, and Web of Science databases, and studies that investigated genetic susceptibility markers for NOC in the Brazilian population were retrieved...
February 15, 2018: Birth defects research
https://www.readbyqxmd.com/read/29442083/cleft-rhinoplasty-columellar-lengthening-comparison-of-techniques
#16
S M Balaji
Background: Nasal deformity in bilateral cleft lip and palate (BCLP) correction is highly challenging. Several solution has been proposed. The aim of the present study is to assess qualitatively and quantitatively the results of Cronin's flap, Fork flap, and Abbe's flap for BCLP rhinoplasty at a follow-up period. Materials and Methods: : Records of all BCLP rhinoplasty performed between 2010 and 2016, fulfilling inclusion and exclusion criteria were collected. From records, qualitative improvement and previously described methods of quantification of columella length were performed...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29440852/rare-variant-of-ankyloblepharon-ectodermal-defect-cleft-lip-cleft-palate-syndrome-curly-hair-ankyloblepharon-nail-disease-syndrome
#17
Ajay Chopra, Debdeep Mitra, Renu Kandpal, Reetu Agarwal
Ankyloblepharon-ectodermal defect-cleft lip/cleft palate (AEC) syndrome is one of the variants of ectodermal dysplasia. It is an autosomal dominant disorder comprising of ankyloblepharon, ectodermal dysplasia, and cleft palate or cleft lip. In 1976, it wasfirst described by Hay and Wells, therefore also known as Hay-Wells syndrome. The characteristic feature of this syndrome is "ankyloblepharon filiforme adnatum", which refers to the partial thickness fusion of the eyelid margins. The "curly hair-ankyloblepharon-nail disease (CHAND) syndrome" is a clinical variant of AEC syndrome...
January 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29437830/face-morphogenesis-is-promoted-by-pbx-dependent-emt-via-regulation-of-snail1-during-frontonasal-prominence-fusion
#18
Marta Losa, Maurizio Risolino, Bingsi Li, James Hart, Laura Quintana, Irina Grishina, Hui Yang, Irene F Choi, Patrick Lewicki, Sameer Khan, Robert Aho, Jennifer Feenstra, C Theresa Vincent, Anthony M C Brown, Elisabetta Ferretti, Trevor Williams, Licia Selleri
Human cleft lip with or without cleft palate (CL/P) is a common craniofacial abnormality caused by impaired fusion of the facial prominences. We have previously reported that in the mouse embryo epithelial apoptosis mediates fusion at the seam where the prominences coalesce. Here, we show that apoptosis alone is not sufficient to remove the epithelial layers. We observed morphological changes in the seam epithelia, intermingling of cells of epithelial descent into the mesenchyme, and molecular signatures of Epithelial-Mesenchymal-Transition (EMT)...
February 5, 2018: Development
https://www.readbyqxmd.com/read/29437516/ideal-versus-late-secondary-alveolar-bone-graft-surgery-a-bone-thickness-cone-beam-computed-tomographic-assessment
#19
Michele Alves Garcia, Marilia Yatabe, Thais Ustulin Fuzer, Adriana Maria Calvo, Ivy Kiemle Trindade-Suedam
OBJECTIVE: To compare the bone morphology after secondary alveolar bone graft surgery (SABG) performed before and after permanent canine eruption. DESIGN: Cross-sectional study. SETTING: Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil. PATIENTS: 25 cone-beam computed tomography (CBCT) scans of complete unilateral cleft lip and palate (CLP) individuals who underwent SABG before or after eruption of the permanent canine taken 2 and 6 months (T1 and T2) after SAGB, resulting in 50 CBCT scans...
March 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29437515/association-between-crispld2-polymorphisms-and-the-risk-of-nonsyndromic-clefts-of-the-lip-and-or-palate-a-meta-analysis
#20
Xing Ge, Qiao-Mei Shi, Zhen Ding, Qiang Ju, Hui Wang, Qi Wang, Meng-Xue Li, Gang Chen, Heng-Xue Wang, Li-Chun Xu
OBJECTIVE: Nonsyndromic clefts of the lip and/or palate (NSCL/P) are one of the most common polygenic diseases. Recently, many studies focused on the association between CRISPLD2 polymorphisms and NSCL/P risk. However, some studies have shown opposite results. In this study, meta-analysis was used to confirm whether CRISPLD2 polymorphism was associated with NSCL/P, and the possible mechanism between CRISPLD2 and NSCL/P was explored. METHODS: Relevant studies were conducted on PubMed, Ovid, EBSCO, CINAHL, FMRS, Web of Science, CNKI, and Wanfang databases from their inception up to June 31, 2016...
March 2018: Cleft Palate-craniofacial Journal
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