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Fulminant hepatic failure

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https://www.readbyqxmd.com/read/29113002/-acute-liver-failure-as-a-rare-case-of-a-frequent-disease
#1
Angela Marie Thiel, Jürgen Rissland, Frank Lammert, Markus Casper
Here we report the case of a 63-year-old female patient who was admitted with acute liver failure. The etiology turned out to be an acute fulminant hepatitis caused by hepatitis C virus (HCV) infection of unknown origin. Fulminant hepatitis due to acute hepatitis C is very rare and hardly reported but a potential cause of acute liver failure due to massive hepatic necrosis, which may lead to encephalitis and multi-organ-failure. During follow-up spontaneous virological clearance was observed. The case illustrates that acute HCV infection, which is confirmed by the detection of HCV-RNA, has to be considered in the differential diagnosis of acute liver failure...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29107021/historical-perspectives-and-advances-in-the-mesenchymal-stem-cell-research-for-the-treatment-of-liver-diseases
#2
REVIEW
Chien-Wei Lee, Yu-Fan Chen, Hao-Hsiang Wu, Oscar K Lee
Liver transplantation is the only effective therapy for patients with decompensated cirrhosis and fulminant liver failure. However, due to a shortage of donor livers and complications associated with immune suppression, there is an urgent need for new therapeutic strategies for patients with end-stage liver diseases. Given their unique function in self-renewal and differentiation potential, stem cells might be used to regenerate damaged liver tissue. Recent studies have shown that stem cell-based therapies can improve liver function in a mouse model of hepatic failure...
October 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29090278/alleviation-of-lipopolysaccharide-d-galactosamine-induced-liver-injury-in-leukocyte-cell-derived-chemotaxin-2-deficient-mice
#3
Akinori Okumura, Takeshi Saito, Minoru Tobiume, Yuki Hashimoto, Yuko Sato, Takashi Umeyama, Minoru Nagi, Koichi Tanabe, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Hideki Hasegawa, Yoshitsugu Miyazaki, Satoshi Yamagoe
Leukocyte cell-derived chemotaxin 2 (LECT2) is a secreted pleiotropic protein that is mainly produced by the liver. We have previously shown that LECT2 plays an important role in the pathogenesis of inflammatory liver diseases. Lipopolysaccharide/d-galactosamine (LPS/d-GalN)-induced acute liver injury is a known animal model of fulminant hepatic failure. Here we found that this hepatic injury was alleviated in LECT2-deficient mice. The levels of TNF-α and IFN-γ, which mediate this hepatitis, had significantly decreased in these mice, with the decrease in IFN-γ production notably greater than that in TNF-α...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29088996/aggressive-treatment-of-life-threatening-hypophosphatemia-during-recovery-from-fulminant-hepatic-failure-a-case-report
#4
Brittany D Bissell, Jason E Davis, Alexander H Flannery, David A Adkins, Melissa L Thompson Bastin
Acute liver failure secondary to acetaminophen overdose can be a life-threatening condition, characterized by severe electrolyte derangements. Hepatocyte regeneration is associated with phosphorous utilization and is a known complication of liver recovery following injury. We report the case of profound, life-threatening hypophosphatemia following recovery from acute fulminant liver failure. As the liver enzymes normalized, serum phosphorous levels plummeted. Our patient required an aggressive, individualized phosphorus replacement regimen, which resulted in a continuous infusion of intravenous (IV) sodium phosphate, titrated to a maximum rate of 30 mmol/h or 0...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29074353/clinical-features-of-regorafenib-induced-liver-injury-in-japanese-patients-from-postmarketing-experience
#5
Hiroyuki Uetake, Kenichi Sugihara, Kei Muro, Toshiyuki Sunaya, Yuka Horiuchi-Yamamoto, Hajime Takikawa
BACKGROUND: Regorafenib (Stivarga) is an oral multikinase inhibitor currently approved for patients with metastatic colorectal cancer or gastrointestinal stromal tumor. Although hepatotoxicity has been a known product profile feature of regorafenib since its initial approval, its clinical features are limited to those found in the clinical trials. PATIENTS AND METHODS: The present study was conducted in 2 analysis sets: a safety analysis set for metastatic colorectal cancer from solicited postmarketing surveillance (PMS) in Japan (n = 1227) and an analysis set for serious hepatic adverse drug reactions (n = 210) from all patients registered for regorafenib use...
September 28, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29057809/hepatoprotective-effects-of-kaempferol-3-o-%C3%AE-l-arabinopyranosyl-7-o-%C3%AE-l-rhamnopyranoside-on-d-galactosamine-and-lipopolysaccharide-caused-hepatic-failure-in-mice
#6
Lin Dong, Lei Yin, Hongfeng Quan, Yuankui Chu, Jincai Lu
Fulminant hepatic failure (FHF), associated with high mortality, is characterized by extensive death of hepatocytes and hepatic dysfunction. There is no effective treatment for FHF. Several studies have indicated that flavonoids can protect the liver from different factor-induced injury. Previously, we found that the extracts of Elaeagnus mollis leaves had favorable protective effects on acute liver injury. However, the role and mechanisms behind that was elusive. This study examined the hepatoprotective mechanisms of kaempferol-3-O-α-l-arabinopyranosyl-7-O-α-l-rhamnopyra-noside (KAR), a major flavonol glycoside of E...
October 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29024015/hepatobiliary-and-pancreatic-fulminant-liver-failure-from-diffuse-leukemoid-hepatic-infiltration-of-melanoma
#7
B Schlevogt, J Rehkämper, B Hild, H H Schmidt
No abstract text is available yet for this article.
November 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28994560/epidemiology-and-pathogenesis-of-fulminant-viral-hepatitis-in-pregnant-women-a-review
#8
Grazia Tosone, Davide Simeone, Anna M Spera, Giulio Viceconte, Vincenzo Bianco, Raffaele Orlando
The pregnancy-associated immunological and hormonal changes may alter the immune response to infectious agents, including hepatitis viruses. Therefore, this phenomenon may affect the clinical course and the outcome of acute viral hepatitis in pregnant women. For this reason, we have focused on epidemiological and pathogenetic aspects of the fulminant liver failure caused by acute viral hepatitis reviewing PubMED in April of 2017. Although all the viruses might cause a fulminant AVH in a pregnant woman, the large majority of fulminant failure reported in the literature had been related to Hepatits E Virus mainly and had been concentrated in Indian subcontinent and some African areas, whereas the problem seems to be very low or absent in the remaining geographical areas...
October 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28957471/malarial-hepatopathy-a-6-year-retrospective-observational-study-from-uttarakhand-north-india
#9
Nidhi Kaeley, Sohaib Ahmad, Nadia Shirazi, Rohan Bhatia, Nowneet K Bhat, Saurabh Srivastava, Minakshi Dhar, Manoj Kumar
Background: Jaundice in malaria is multifactorial. Plasmodium falciparum causes malarial hepatopathy in around 2.5% of cases. The spectrum of hepatic dysfunction in patients with malaria varies from mild clinical and biochemical abnormalities to fulminant hepatic failure, although hepatic encephalopathy almost never occurs. We undertook this study in order to estimate the magnitude of hepatopathy in malaria, and study the associated clinical features, complications and outcome of patients...
May 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28953903/interleukin-1%C3%AE-and-interleukin-1%C3%AE-play-a-central-role-in-the-pathogenesis-of-fulminant-hepatic-failure-in-mice
#10
Maya Sultan, Ziv Ben-Ari, Rula Masoud, Orit Pappo, Dror Harats, Yehuda Kamari, Michal Safran
BACKGROUND AND AIMS: Fulminant hepatitis failure (FHF) is marked by the sudden loss of hepatic function, with a severe life-threatening course in persons with no prior history of liver disease. Interleukin (IL)-1α and IL-1β are key inflammatory cytokines but little is known about their role in the development of FHF. The aim of this study was to assess the involvement of IL-1α and IL-1β in the progression of LPS/GalN-induced FHF. METHODS: WT, IL-1α or IL-1β deficient mice were injected with LPS/GalN...
2017: PloS One
https://www.readbyqxmd.com/read/28951776/hepatitis-b-in-patients-with-hematological-diseases-an-update
#11
REVIEW
Chiara Coluccio, Paola Begini, Alfredo Marzano, Adriano Pellicelli, Barbara Imperatrice, Giulia Anania, Gianfranco Delle Fave, Massimo Marignani
Hepatitis B virus (HBV) reactivation (HBVr) in patients undergoing immunosuppressive therapy is still a hot topic worldwide. Its prevention and management still represents a challenge for specialists dealing with immunosuppressed patients. Aim of this paper is to provide a critical review of the relevant information emerged in the recent literature regarding HBV reactivation following immunosuppressive treatments for oncohematological tumors. A computerized literature search in MEDLINE was performed using appropriate terms arrangement, including English-written literature only or additional relevant articles...
September 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28912916/acute-liver-failure-in-a-patient-travelling-from-asia-the-other-face-of-the-coin-of-infectious-disease
#12
Balen Abdulrahman, Mohamed H Ahmed, John Ramage
We present a case of a 63-year-old male who had travelled from South India to United Kingdom (UK) visiting relatives. He had developed episodes of diarrhea, vomiting and fevers while travelling and on assessment in hospital, mild abdominal distension was noted with rapid deterioration to hypovolemic shock. Initial blood test showed a low platelet count with deranged liver function tests (LFTs). It was noted that during admission to intensive care unit (ICU), blood continued to ooze from a previous surgical laparoscopy wound, central and arterial line access sites...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28906278/hepatitis-b-reactivation-in-a-long-term-nonprogressor-due-to-nivolumab-therapy
#13
Adam C Lake
: Hepatitis B virus (HBV) reactivation has been documented in association with multiple immunotherapy regimens . These reactivations can be life-threatening and result in fulminant hepatic failure. There are currently no reports of HBV reactivation on nivolumab treatment. This is a case of a patient with known HIV infection and previous HBV workup that revealed him to be anti-hepatitis B core antibody positive, hepatitis B surface antigen negative, and HBV DNA negative. He experienced a HBV reactivation while on therapy with nivolumab for stage IIIa poorly differentiated carcinoma of the lung, which was a recurrence from a prior surgically resected stage Ia well differentiated adenocarcinoma of the lung...
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28870776/consensus-report-by-the-pediatric-acute-lung-injury-and-sepsis-investigators-and-pediatric-blood-and-marrow-transplantation-consortium-joint-working-committees-on-supportive-care-guidelines-for-management-of-veno-occlusive-disease-in-children-and-adolescents
#14
Nadia Ovchinsky, Warren Frazier, Jeffery J Auletta, Christopher C Dvorak, Monica Ardura, Enkyung Song, Jennifer McArthur, Asumthia Jeyapalan, Robert Tamburro, Kris M Mahadeo, Chani Traube, Christine N Duncan, Rajinder P S Bajwa
Some patients with veno-occlusive disease (VOD) have multiorgan dysfunction, and multiple teams are involved in their daily care in the pediatric intensive care unit. Cardiorespiratory dysfunction is critical in these patients, requiring immediate action. The decision of whether to use a noninvasive or an invasive ventilation strategy may be difficult in the setting of mucositis or other comorbidities in patients with VOD. Similarly, monitoring of organ function may be very challenging in these patients, who may have fulminant hepatic failure with or without hepatic encephalopathy complicated by delirium and/or infections...
September 1, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28858213/recreational-exposure-during-algal-bloom-in-carrasco-beach-uruguay-a-liver-failure-case-report
#15
Flavia Vidal, Daniela Sedan, Daniel D'Agostino, María Lorena Cavalieri, Eduardo Mullen, María Macarena Parot Varela, Cintia Flores, Josep Caixach, Dario Andrinolo
In January 2015, a 20-month-old child and her family took part in recreational activities at Carrasco and Malvín beaches (Montevideo, Uruguay). An intense harmful algae bloom (HAB) was developing along the coast at that time. A few hours after the last recreational exposure episode, the family suffered gastrointestinal symptoms which were self-limited except in the child's case, who was admitted to hospital in Uruguay with diarrhea, vomiting, fatigue, and jaundice. The patient had increased serum levels of liver enzymes and bilirubin and five days later presented acute liver failure...
August 31, 2017: Toxins
https://www.readbyqxmd.com/read/28835860/herpes-simplex-virus-hepatitis-a-presentation-of-multi-institutional-cases-to-promote-early-diagnosis-and-management-of-the-disease
#16
Ashwinee Natu, Guiseppe Iuppa, Clifford D Packer
OBJECTIVE: To compare three cases of Herpes simplex virus (HSV) hepatitis to increase early diagnosis of the disease. Case  1. A 23-year-old man with Crohn's disease and oral HSV. HSV hepatitis was diagnosed clinically and he improved with acyclovir. Case  2. An 18-year-old G1P0 woman with transaminitis. Despite early empiric acyclovir therapy, she died due to fulminant liver failure. Case  3. A 65-year-old woman who developed transaminitis after liver transplant. Diagnosis was confirmed by biopsy and she had resolution of acute liver failure with acyclovir...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/28830233/investigating-and-analyzing-three-cohorts-of-mushroom-poisoning-caused-by-amanita-exitialis-in-yunnan-china
#17
J Sun, H-J Li, H-S Zhang, Y-Z Zhang, J-W Xie, P-B Ma, C Guo, C Y Sun
Amanita exitialis is a lethal mushroom found in China. Knowledge regarding taxonomic characterization, toxin detection, general poisoning conditions, clinical manifestations, laboratory examinations, and clinical treatments for this species is currently lacking. We investigated three A. exitialis mushroom poisoning cohorts in Yunnan Province in 2014 and 2015, involving 10 patients. Mushroom samples were identified by morphological and molecular studies. Ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry was used to detect the peptide toxins in the mushroom samples...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28813731/a-case-of-fulminant-hepatic-failure-secondary-to-congestive-heart-failure-without-evidence-of-acute-cardiac-decompensation
#18
Kalyan Wagle, Oluwaseun A Akinseye, Prakash Shrestha, Madhuri Chandnani, Raiko Munankarmi, Vivian Ripin, Jimmy Yee
There are so far only a few reported cases of acute fulminant hepatic failure resulting from acute cardiomyopathy. This is a rare occurrence, especially in patients that do not exhibit any signs and symptoms of acute cardiac decompensation. We report a case of fulminant liver failure with nondiagnostic work up for the common causes of liver failure. This patient had concurrent history of congestive heart failure, but did not have acute decompensation. Right upper quadrant sonogram revealed hepatomegaly of 15 cm, trace amount of perihepatic ascites, pericholecystic fluid, and also thickened edematous gallbladder wall with no stones, no common bile duct stones, and no portal vein thrombosis...
April 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28798927/is-dengue-emerging-as-important-cause-of-acute-liver-failure-in-endemic-regions
#19
Lavleen Singh, Amitabh Singh, Mitali Agarwal, Sataroopa Mishra
Dengue virus infection continues to be major public health problem in large part of world. The epidemiology of dengue viral infection is becoming increasingly complex and has substantially changed over almost past six decades not only in terms of prevalent strains and geographical locations but also in terms of disease severity and atypical presentations. Though liver is the most common organ affected but is generally asymptomatic. We present a case of infant with severe dengue who died of fulminant hepatic failure and showed pan lobular necrosis on post mortem liver biopsy...
July 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28781827/deferasirox-associated-with-liver-failure-and-death-in-a-sickle-cell-anemia-patient-homozygous-for-the-1774delg-polymorphism-in-the-abcc2-gene
#20
Caroline C B Braga, Bruno Deltreggia Benites, Dulcineia M de Albuquerque, Marisa C Alvarez, Tiago Seva-Pereira, Bruno K L Duarte, Fernando F Costa, Simone C O Gilli, Sara T O Saad
This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the -1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context.
August 2017: Clinical Case Reports
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