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https://www.readbyqxmd.com/read/29453543/toxic-and-beneficial-potential-of-silver-nanoparticles-the-two-sides-of-the-same-coin
#1
Lilian Rodrigues Rosa Souza, Veronica Santana da Silva, Leonardo Pereira Franchi, Tiago Alves Jorge de Souza
Nanotechnology has allowed great changes in chemical, biological and physical properties of metals when compared to their bulk counterparts. Within this context, silver nanoparticles (AgNPs) play a major role due to their unique properties, being widely used in daily products such as fabrics, washing machines, water filters, food and medicine. However, AgNPs can enter cells inducing a "Trojan-horse" type mechanism which potentially leads to cellular autophagy, apoptosis or necrosis. On the other hand, this cytotoxicity mechanism can be optimized to develop drug nanocarriers and anticancer therapies...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29452191/recent-advances-of-medical-foods-in-china-the-opportunities-and-challenges-under-standardization
#2
Xusheng Li, Xinwei Jiang, Jianxia Sun, Cuijuan Zhu, Weibin Bai
Malnutrition with high incidence in hospitalized patients in China has brought a significant burden of disease. Although many clinical studies have demonstrated the importance of nutritional for patients with malnutrition, the application of medical foods in China is still restricted. For the classification, limits, production and registration of medical foods, the Chinese government newly enacted a series of regulations. In this review, comparing the policy, researches, and product variety of medical foods in China with other countries, although the current status of the development of medical foods in China is still far behind that of developed countries, some of regulations are stricter than those of many other countries or organizations...
February 13, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29451810/recent-developments-in-the-food-quality-detected-by-non-invasive-nuclear-magnetic-resonance-technology
#3
Kai Fan, Min Zhang
Nuclear magnetic resonance (NMR) is a rapid, accurate and non-invasive technology and widely used to detect the quality of food, particularly to fruits and vegetables, meat and aquatic products. This review is a survey of recent developments in experimental results for the quality of food on various NMR technologies in processing and storage over the past decade. Following a discussion of the quality discrimination and classification of food, analysis of food compositions and detection of physical, chemical, structural and microbiological properties of food are outlined...
February 16, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29451784/alteration-of-crop-yield-and-quality-of-wheat-upon-exposure-to-silver-nanoparticles-in-a-life-cycle-study
#4
Jie Yang, Fuping Jiang, Chuanxin Ma, Yu-Kui Rui, Mengmeng Rui, Adeel Muhammad, Weidong Cao, Baoshan Xing
Due to the rapid development of nanotechnology, metal-based nanoparticles (NPs) are inadvertently released into environment and may pose a potential threat to ecosystem. However, information for food quality and safety in NP treated crops is limited. In the present study, wheat (Triticum aestivum L.) was grown in different concentrations of Ag NP amended soil (20, 200, and 2000 mg•kg-1) for four months. At harvest, physiological parameters, Ag and micronutrients (Fe, Cu, and Zn) content, as well as amino acid and protein contents were measured...
February 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29451115/understanding-the-complexities-of-food-safety-using-a-one-health-approach
#5
Kalmia E Kniel, Deepak Kumar, Siddhartha Thakur
The philosophy of One Health is growing in concept and clarity. The interdependence of human, animal, and environmental health is the basis for the concept of One Health. One Health is a comprehensive approach to ensure the health of people, animals, and the environment through collaborative efforts. Preharvest food safety issues align with the grand concept of One Health. Imagine any food production system, and immediately, parallel images from One Health emerge: for example, transmission of zoonotic diseases, antibiotic residues, or resistance genes in the environment; environmental and animal host reservoirs of disease; challenges with rearing animals and growing fresh produce on the same farm; application and transport of manure or diseased animals...
February 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29451114/molecular-tools-to-study-preharvest-food-safety-challenges
#6
Deepak Kumar, Siddhartha Thakur
Preharvest food safety research and activities have advanced over time with the recognition of the importance and complicated nature of the preharvest phase of food production. In developed nations, implementation of preharvest food safety procedures along with strict monitoring and containment at various postharvest stages such as slaughter, processing, storage, and distribution have remarkably reduced the burden of foodborne pathogens in humans. Early detection and adequate surveillance of pathogens at the preharvest stage is of the utmost importance to ensure a safe meat supply...
February 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29450684/application-and-impact-of-run-in-studies
#7
Michael Fralick, Jerry Avorn, Jessica M Franklin, Abdurrahman Abdurrob, Aaron S Kesselheim
BACKGROUND: A run-in phase is often employed prior to randomization in a clinical trial to exclude non-adherent patients, placebo responders, active drug non-responders, or patients who do not tolerate the active drug. This may impact the generalizability of trial results. OBJECTIVE: To determine if clinical outcomes differed between randomized controlled trials with run-in phases compared with randomized controlled trials of the same medication without run-in phases...
February 15, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29449781/whole-genome-sequencing-of-multidrug-resistant-salmonella-enterica-serovar-typhimurium-isolated-from-humans-and-poultry-in-burkina-faso
#8
Assèta Kagambèga, Taru Lienemann, Jonathan G Frye, Nicolas Barro, Kaisa Haukka
Background: Multidrug-resistant Salmonella is an important cause of morbidity and mortality in developing countries. The aim of this study was to characterize and compare multidrug-resistant Salmonella enterica serovar Typhimurium isolates from patients and poultry feces. Methods: Salmonella strains were isolated from poultry and patients using standard bacteriological methods described in previous studies. The strains were serotype according to Kaufmann-White scheme and tested for antibiotic susceptibility to 12 different antimicrobial agents using the disk diffusion method...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29449204/national-food-nutrition-and-physical-activity-survey-of-the-portuguese-general-population-2015-2016-protocol-for-design-and-development
#9
Carla Lopes, Duarte Torres, Andreia Oliveira, Milton Severo, Sofia Guiomar, Violeta Alarcão, Elisabete Ramos, Sara Rodrigues, Sofia Vilela, Luísa Oliveira, Jorge Mota, Pedro J Teixeira, Paulo J Nicola, Simão Soares, Lene Frost Andersen
BACKGROUND: The assessment of food consumption data using harmonized methodologies at the European level is fundamental to support the development of public policies. Portugal is one of the countries with the most outdated information on individual food consumption. OBJECTIVE: The objective of this study was to describe the design and methodology of the National Food, Nutrition and Physical Activity Survey, 2015-2016, developed to collect national and regional data on dietary habits, physical activity (PA), and nutritional status, in a representative sample of the Portuguese general population (3 months-84 years)...
February 15, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29448094/the-prevalence-and-antimicrobial-resistance-of-listeria-spp-in-raw-milk-and-traditional-dairy-products-delivered-in-yazd-central-iran-2016
#10
Fateme Akrami-Mohajeri, Zahra Derakhshan, Margherita Ferrantee, Negar Hamidiyan, Meysam Soleymani, Gea Oliveri Conti
Listeria monocytogenes is an important foodborne pathogen which its data in Iranian dairy products is limited. A total of 545 samples of traditional dairy products (raw milk, traditional cheese, traditional butter, traditional curd, and traditional ice cream) were collected from traditional dairy shops located in Yazd, Iran. L. monocytogenes was isolated, and positive samples were confirmed by polymerase chain reaction. Antibiotic sensitivity test was conducted to determine the antibiotic resistance. Listeria species were isolated from 11...
February 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29447670/rapid-screening-of-basic-colorants-in-processed-vegetables-through-mass-spectrometry-using-an-interchangeable-thermal-desorption-electrospray-ionization-source
#11
Yu-Ying Chao, Yen-Ling Chen, Hong-Yi Lin, Yeou-Lih Huang
Thermal desorption electrospray ionization/mass spectrometry (TD-ESI-MS) employing a quickly interchangeable ionization source is a relatively new ambient ionization mass spectrometric technique that has had, to date, only a limited number of applications related to food safety control. With reallocation of resources, this direct-analysis technique has had wider use in food analysis when operated in dual-working mode (pretreatment-free qualitative screening and conventional quantitative confirmation) after switching to an ambient ionization source from a traditional atmospheric pressure ionization source...
June 20, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29446998/considerations-for-clinical-review-of-cellular-therapy-products-perspectives-of-the-china-food-and-drug-administration-center-for-drug-evaluation
#12
Yantong Liu, Chenyang Zhao, Liucun Gao, Huan Yang, Ruyi He, Chenyan Gao
With increasing numbers of technical developments and clinical studies, pioneering cellular/gene therapies are now available that could cure life-threatening disease. Cellular/gene therapy products are broad-ranging and complicated, and thereby bring challenges for clinical review by regulatory agencies. This review discusses principles for the clinical review of cellular therapy products, including protection of clinical trial populations, pharmacodynamics, pharmacokinetics, dose evaluation, clinical efficacy, clinical safety, and risk-management plans...
February 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29446666/the-impact-of-climate-change-on-raw-and-untreated-wastewater-use-for-agriculture-especially-in-arid-regions-a-review
#13
Dima Faour-Klingbeil, Ewen C D Todd
Climate change is one of the major challenges of our time that pose unprecedented stress to the environment and threats to human health. The global impacts of climate change are vast, spanning from extreme weather events to changes in patterns and distribution of infectious diseases. Lack of rainfall associated with higher temperatures has a direct influence on agricultural production. This is compounded by a growing population forecasted to expand further with increasing needs for food and water. All this has led to the increasing use of wastewater worldwide...
February 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29446185/chart-validation-of-inpatient-icd-9-cm-administrative-diagnosis-codes-for-acute-myocardial-infarction-ami-among-intravenous-immune-globulin-igiv-users-in-the-sentinel-distributed-database
#14
Eric M Ammann, Marin L Schweizer, Jennifer G Robinson, Jayasheel O Eschol, Rami Kafa, Saket Girotra, Scott K Winiecki, Candace C Fuller, Ryan M Carnahan, Charles E Leonard, Cole Haskins, Crystal Garcia, Elizabeth A Chrischilles
BACKGROUND: The Sentinel Distributed Database (SDD) is a large database of patient-level administrative health care records, primarily derived from insurance claims and electronic health records, and is sponsored by the US Food and Drug Administration for medical product safety evaluations. Acute myocardial infarction (AMI) is a common study endpoint for drug safety studies that rely on health records from the SDD and other administrative databases. PURPOSE: In this chart validation study, we report on the positive predictive value (PPV) of inpatient International Classification of Diseases, Ninth Revision, Clinical Modification AMI administrative diagnosis codes (410...
February 15, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29446033/climate-change-foodborne-pathogens-and-illness-in-higher-income-countries
#15
REVIEW
I R Lake, G C Barker
PURPOSE OF REVIEW: We present a review of the likely consequences of climate change for foodborne pathogens and associated human illness in higher-income countries. RECENT FINDINGS: The relationships between climate and food are complex and hence the impacts of climate change uncertain. This makes it difficult to know which foodborne pathogens will be most affected, what the specific effects will be, and on what timescales changes might occur. Hence, a focus upon current capacity and adaptation potential against foodborne pathogens is essential...
February 14, 2018: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29445835/application-and-evaluation-of-a-high-resolution-mass-spectrometry-screening-method-for-veterinary-drug-residues-in-incurred-fish-and-imported-aquaculture-samples
#16
Sherri B Turnipseed, Joseph M Storey, I-Lin Wu, Charles M Gieseker, Nicholas R Hasbrouck, Tina C Crosby, Wendy C Andersen, Shanae Lanier, Christine R Casey, Robert Burger, Mark R Madson
The ability to detect chemical contaminants, including veterinary drug residues in animal products such as fish, is an important example of food safety analysis. In this paper, a liquid chromatography high-resolution mass spectrometry (LC-HRMS) screening method using a quadrupole-Orbitrap instrument was applied to the analysis of veterinary drug residues in incurred tissues from aquacultured channel catfish, rainbow trout, and Atlantic salmon and imported aquacultured products including European eel, yellow croaker, and tilapia...
February 14, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29444650/designing-a-behavioral-intervention-using-the-com-b-model-and-the-theoretical-domains-framework-to-promote-gas-stove-use-in-rural-guatemala-a-formative-research-study
#17
Lisa M Thompson, Anaité Diaz-Artiga, John R Weinstein, Margaret A Handley
BACKGROUND: Three billion people use solid cooking fuels, and 4 million people die from household air pollution annually. Shifting households to clean fuels, like liquefied petroleum gas (LPG), may protect health only if stoves are consistently used. Few studies have used an implementation science framework to systematically assess "de-implementation" of traditional stoves, and none have done so with pregnant women who are more likely to adopt new behaviors. We evaluated an introduced LPG stove coupled with a phased behavioral intervention to encourage exclusive gas stove use among pregnant women in rural Guatemala...
February 14, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29444637/estimated-assessment-of-cumulative-dietary-exposure-to-organophosphorus-residues-from-tea-infusion-in-china
#18
Pei Cao, Dajin Yang, Jianghui Zhu, Zhaoping Liu, Dingguo Jiang, Haibin Xu
BACKGROUND: China has the world's largest tea plantation area in the world. To sustain high yields of the tea, multiple pesticides are used on tea crops to control pests. Organophosphorus (OP) pesticides are among the most widely used types of agricultural pesticides in China. As tea is a significant potential source of exposure to pesticide residues, the public concern has increased in relation to pesticide residues found in tea in China. The aim of the study was to estimate cumulative dietary exposure to OP residues from tea infusion for Chinese tea consumers to determine whether exposure to OP residues from tea infusion is a cause of health concern for tea consumers in China...
February 14, 2018: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29444134/effect-of-antibiotic-withdrawal-in-feed-on-chicken-gut-microbial-dynamics-immunity-growth-performance-and-prevalence-of-foodborne-pathogens
#19
Sanjay Kumar, Chongxiao Chen, Nagaraju Indugu, Gabriela Orosco Werlang, Manpreet Singh, Woo Kyun Kim, Harshavardhan Thippareddi
Development of antibiotic resistance in foodborne pathogens, Salmonella spp. and Campylobacter, is a public health concern. Public demand to reduce the use of sub-therapeutic antibiotic growth promoters (AGP) in poultry feeding has resulted in greater adoption of antibiotic-free poultry production systems. There is a need to understand the effects of AGP removal from poultry feed on gut microbiota and its impact on prevalence of foodborne pathogens. The effect of antibiotic withdrawal from poultry feed on gut microbial community, host performance and immunity, and prevalence of Salmonella and Campylobacter was evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29443929/claimed-effects-outcome-variables-and-methods-of-measurement-for-health-claims-on-foods-related-to-vision-proposed-under-regulation-ec-1924-2006
#20
Daniela Martini, Augusto Innocenti, Chiara Cosentino, Giorgio Bedogni, Donato Angelino, Beatrice Biasini, Ivana Zavaroni, Marco Ventura, Daniela Galli, Prisco Mirandola, Marco Vitale, Alessandra Dei Cas, Riccardo C Bonadonna, Giovanni Passeri, Carlo Pruneti, Daniele Del Rio
Adequate visual function has a strong impact on the quality of life of people. Several foods and food components have been hypothesized to play a role in the maintenance of normal visual function and in the prevention of eye diseases. Some of these foods/food components have been the object of a request of authorization for use of health claims under Articles 13(5) or 14 of the Regulation (EC) 1924/2006. Most of these requests have received a negative opinion from the European Food Safety Authority (EFSA) due to the choice of inappropriate outcome variables (OVs) and/or methods of measurement (MMs) applied in the studies used to substantiate the claims...
February 14, 2018: Nutrients
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