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https://www.readbyqxmd.com/read/29223706/cross-over-clinical-trial-for-evaluating-the-safety-of-camel-s-milk-intake-in-patients-who-are-allergic-to-cow-s-milk-protein
#1
E M Navarrete-Rodríguez, L A Ríos-Villalobos, C R Alcocer-Arreguín, B E Del-Rio-Navarro, J M Del Rio-Chivardi, O J Saucedo-Ramírez, J J L Sienra-Monge, R V Frias
BACKGROUND: Cow's milk protein allergy (CMPA) affects between 0.6 and 0.9% of the general population, and its treatment implies the total elimination of the intake of this protein. Camel's milk has been suggested as an alternative for patients over one year of age who suffer from CMPA due to the difference in the amino acid sequence from that of cow's milk. The objective of this study was to evaluate the safety and tolerability of camel's milk in children with CMPA. METHODS: Crossed clinical trial for the use of camel's milk vs...
December 6, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29223428/enabling-social-listening-for-cardiac-safety-monitoring-proceedings-from-a-drug-information-association-cardiac-safety-research-consortium-cosponsored-think-tank
#2
REVIEW
Harry A Seifert, Raleigh E Malik, Mondira Bhattacharya, Kevin R Campbell, Sally Okun, Carrie Pierce, Jeffrey Terkowitz, J Rick Turner, Mitchell W Krucoff, Gregory E Powell
This white paper provides a summary of the presentations and discussions from a think tank on "Enabling Social Listening for Cardiac Safety Monitoring" trials that was cosponsored by the Drug Information Association and the Cardiac Safety Research Consortium, and held at the White Oak headquarters of the US Food and Drug Administration on June 3, 2016. The meeting's goals were to explore current methods of collecting and evaluating social listening data and to consider their applicability to cardiac safety surveillance...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29222655/levels-dietary-intake-and-health-risk-of-potentially-toxic-metals-in-vegetables-fruits-and-cereal-crops-in-pakistan
#3
Javed Nawab, Saad Farooqi, Wang Xiaoping, Sardar Khan, Asad Khan
Food safety is a major concern worldwide and human beings are frequently exposed to potentially toxic metals (PTMs) through consumption of vegetables, fruits, and cereal crops grown in contaminated areas. The present study investigates the concentrations of PTMs such as chromium (Cr), nickel (Ni), zinc (Zn), arsenic (As), cadmium (Cd), and lead (Pb) in the foodstuffs (fruits, vegetables, and cereals) collected from different markets of Khyber Pakhtunkhwa, Pakistan. Samples of fruits (banana, tangerine, apple, and guava), vegetables (tomato, onion, potato, pea, and lady finger), and cereals (rice, kidney beans, and chick peas) were acid-extracted and analyzed using ICP-MS...
December 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29222652/development-of-a-kelp-powder-thallus-laminariae-standard-reference-material
#4
Lee L Yu, Joseph F Browning, Carolyn Q Burdette, George C Caceres, Kaitlyn D Chieh, W Clay Davis, Brittany L Kassim, Stephen E Long, Karen E Murphy, Rabia Oflaz, Rick L Paul, Katherine E Sharpless, Laura J Wood, James H Yen, Rolf Zeisler
A Standard Reference Material (SRM) of seaweed, SRM 3232 Kelp Powder (Thallus laminariae) has been developed to support food and dietary supplement measurements in compliance with the Food Safety Modernization Act (FSMA) and the Dietary Supplement Health and Education Act of 1994 (DSHEA). The material was characterized for nutritional minerals, arsenic species, isomers of vitamin K1, proximates, and toxic elements. Kelp is a rich source of vitamins and minerals, and it is an excellent source of dietary iodine...
December 9, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29222405/multiple-weekly-dalbavancin-dosing-for-the-treatment-of-native-vertebral-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-report
#5
Thamer A Almangour, Valerie Fletcher, Mohammed Alessa, Abdullah A Alhifany, Deanne Tabb
BACKGROUND Native vertebral osteomyelitis (NVO) is a common form of hematogenous osteomyelitis, with Staphylococcus aureus (S. aureus) being the most commonly isolated organism. Dalbavancin is approved by the US Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and has a sufficiently promising pharmacokinetic and pharmacodynamic profile to be considered for the treatment of vertebral osteomyelitis. We describe here what is probably the first reported case of using multiple weekly dalbavancin to treat a complicated methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and vertebral osteomyelitis...
December 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29222054/caramel-color-safety-an-update
#6
REVIEW
Thomas A Vollmuth
Caramel color has been used in foods and beverages for over 150 years and is globally regulated as a color additive. The four distinct classes of caramel color (Plain Caramel, Sulfite Caramel, Ammonia Caramel, and Sulfite Ammonia Caramel) are well characterized and each have specifications that take into account processing variables including reactants that can give rise to low molecular weight constituents (e.g., 4-MeI and THI) that may have toxicological significance for evaluating safety. Extensive safety testing has been conducted with the different classes of caramel color and its constituents, including toxicokinetics, genotoxicity, subchronic toxicity, carcinogenicity, and reproductive/developmental toxicity studies...
December 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29221797/evaluation-of-dose-dependent-antimicrobial-activity-of-self-assembled-chitosan-nano-silver-and-chitosan-nano-silver-composite-against-several-pathogens
#7
Foysal Kabir Tareq, Mst Fayzunnesa, Md Shahariar Kabir, Musrat Nuzat
The aim of this investigation to preparation of silver nanoparticles organized chitosan nano polymer, which effective against microbial and pathogens, when apply to liquid medium and edible food products surface, will rescue the growth of microbes. Self-assembly approach used to synthesis of silver nanoparticles and silver nanoparticles organized chitosan nano polymer. Silver nanoparticles and silver nanoparticles organized chitosan nano polymer and film characterized using Ultra-violate visible spectrometer (UV-vis), X-ray diffraction (X-ray), and Scanning electronic microscope (SEM)...
December 5, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29220861/do-we-need-plant-food-supplements-a-critical-examination-of-quality-safety-efficacy-and-necessity-for-a-new-regulatory-framework
#8
Mona Abdel-Tawab
Given the expanding market of plant food supplements (PFSs) not undergoing any pre-marketing authorization, the overall quality, safety and efficacy of PFSs were subjected to a critical examination. Although many high-quality PFSs exist on the legal market, quality concerns are in general justified. Besides economic adulteration, active ingredients dramatically differing from label claims and among products were reported in several studies. In addition, PFSs sold via the Internet may be intentionally adulterated with undeclared prescription drugs...
December 8, 2017: Planta Medica
https://www.readbyqxmd.com/read/29220375/construction-and-validation-of-a-psychometric-scale-to-measure-awareness-on-consumption-of-irradiated-foods
#9
Tiago Rusin, Wilma Maria Coelho Araújo, Cristiane Faiad, Helio de Carvalho Vital
Although food irradiation has been used to ensure food safety, most consumers are unaware of the basic concepts of irradiation, misinterpreting information and demonstrating a negative attitude toward food items treated with ionizing radiation. This research is aimed at developing a tool to assess the awareness on the consumption of irradiated food. The sample was composed by employees from different social classes and school levels of Brazilian universities, who reflect the end-users of the irradiated foods, representative of the views of lay consumers...
2017: PloS One
https://www.readbyqxmd.com/read/29219744/n-nitrosamines-migrating-from-food-contact-materials-into-food-simulants-analysis-and-quantification-by-means-of-hplc-apci-ms-ms
#10
Friederike Kühne, Oliver Kappenstein, Samira Straβgütl, Florian Weese, Jürgen Weyer, Karla Pfaff, Andreas Luch
It was the aim of the work described here to develop a validated analytical method for the determination N-nitrosamines in food simulants. Here, we present the validation of a liquid chromatography-atmospheric pressure chemical ionisation-tandem mass spectrometry (LC-APCI-MS/MS) method for the determination of thirteen N-nitrosamines in the food simulants deionised water, 3 % acetic acid and 10 % ethanol. Method validation encompassed linearity, limit of detection (LOD), limit of quantification (LOQ), recovery, precision and stability of the N-nitrosamines...
December 8, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29219139/a-point-source-outbreak-of-acute-gastroenteritis-among-school-students-in-kerala-india
#11
P S Rakesh, Rajeswaran Thiagesan, Rakesh Ramachandran
An outbreak investigation was initiated following an outbreak of acute gastroenteritis among schoolchildren in Kottarakara. Steps included active search for cases at schools, describing the outbreak in terms of person, place, and time, generating hypothesis based on the findings from descriptive study, environmental observations, and testing the hypothesis using a case-control design. The final line list consisted of 871 children from different schools who attended a Republic Day parade. Having consumed the lemon juice near railway station (odds ratio [OR] 29...
October 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29219089/health-impacts-of-climate-change-and-health-and-social-inequalities-in-the-uk
#12
REVIEW
Jouni Paavola
This article examines how social and health inequalities shape the health impacts of climate change in the UK, and what the implications are for climate change adaptation and health care provision. The evidence generated by the other articles of the special issue were interpreted using social justice reasoning in light of additional literature, to draw out the key implications of health and social inequalities for health outcomes of climate change. Exposure to heat and cold, air pollution, pollen, food safety risks, disruptions to access to and functioning of health services and facilities, emerging infections and flooding are examined as the key impacts of climate change influencing health outcomes...
December 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29218888/identifying-natural-health-product-and-dietary-supplement-information-within-adverse-event-reporting-systems
#13
Vivekanand Sharma, Indra Neil Sarkar
Data on safety and efficacy issues associated with natural health products and dietary supplements (NHP&S) remains largely cloistered within domain specific databases or embedded within general biomedical data sources. A major challenge in leveraging analytic approaches on such data is due to the inefficient ability to retrieve relevant data, which includes a general lack of interoperability among related sources. This study developed a thesaurus of NHP&S ingredient terms that can be used by existing biomedical natural language processing (NLP) tools for extracting information of interest...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218811/exploring-the-chemistry-of-complex-samples-by-tentative-identification-and-semi-quantification-a-food-contact-material-case
#14
Eelco N Pieke, Jørn Smedsgaard, Kit Granby
In fields such as food safety and environmental chemistry, ensuring safety is greatly challenged by large numbers of unknown substances occurring. Even with current state of the art mass spectrometers, dealing with non-identified substances is a very laborious process as it includes structure elucidation of a vast number of unknowns, of which only a fraction may be relevant. Here, we present an exploration and prioritization approach based on high resolution mass spectrometry. The method uses algorithm-based precursor/product-ion correlations on Quadrupole-Time of Flight (Q-TOF) MS/MS data to retrieve the most likely chemical match from a structure database...
December 8, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29218304/from-invention-to-innovation-risk-analysis-to-integrate-one-health-technology-in-the-dairy-farm
#15
Andrea Lombardo, Carlo Boselli, Simonetta Amatiste, Simone Ninci, Chiara Frazzoli, Roberto Dragone, Alberto De Rossi, Gerardo Grasso, Alberto Mantovani, Giovanni Brajon
Current Hazard Analysis Critical Control Points (HACCP) approaches mainly fit for food industry, while their application in primary food production is still rudimentary. The European food safety framework calls for science-based support to the primary producers' mandate for legal, scientific, and ethical responsibility in food supply. The multidisciplinary and interdisciplinary project ALERT pivots on the development of the technological invention (BEST platform) and application of its measurable (bio)markers-as well as scientific advances in risk analysis-at strategic points of the milk chain for time and cost-effective early identification of unwanted and/or unexpected events of both microbiological and toxicological nature...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29216552/geographic-and-host-size-variations-as-indicators-of-anisakis-pegreffii-infection-in-european-pilchard-sardina-pilchardus-from-the-mediterranean-sea-food-safety-implications
#16
Ivana Bušelić, Antonela Botić, Jerko Hrabar, Nika Stagličić, Paolo Cipriani, Simonetta Mattiucci, Ivona Mladineo
European pilchards are traditionally eaten marinated or salted in the Mediterranean countries often without thermal processing or gutting due to small size. Since ingestion of live third stage Anisakis larvae represents a causing agent in the onset of anisakiasis, the aim of our study was to assess prevalence and intensity of Anisakis infection in European pilchards originating from different Mediterranean regions in a three-year sampling period (2013-2015). A total of 1564 specimens of European pilchard collected from two geographically distinct sampling regions (western Mediterranean and Adriatic Sea) were examined using the UV-Press method, which utilises the fluorescence of frozen anisakids in flattened and subsequently frozen fillets and viscera...
November 29, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29215916/new-and-incremental-fda-black-box-warnings-from-2008-to-2015
#17
Michael T Solotke, Sanket S Dhruva, Nicholas S Downing, Nilay D Shah, Joseph S Ross
BACKGROUND: The boxed warning (also known as "black box warning [BBW]") is one of the strongest drug safety actions that the U.S. Food & Drug Administration (FDA) can implement, and often warns of serious risks. The objective of this study was to comprehensively characterize BBWs issued for drugs after FDA approval. METHODS: We identified all post-marketing BBWs from January 2008 through June 2015 listed on FDA's MedWatch and Drug Safety Communications websites...
December 7, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29214564/undiagnosed-diseases-italy-us-collaboration-and-international-efforts-to-tackle-rare-and-common-diseases-lacking-a-diagnosis
#18
Domenica Taruscio, Giovanna Floridia, Marco Salvatore, Stephen C Groft, William A Gahl
Rare diseases (RD), according to European Union criteria, affect 5 per 10,000 persons, or 30 million people, in the EU; in the USA, RD are defined as conditions that affect fewer than 200,000 individuals in the population (320 million). Most known rare disorders are severe and chronic, with many being degenerative and life threatening. There are roughly 5000-8000 rare diseases (European Commission, DG Health and Food Safety, Public Health, Rare Diseases, Policy.http://ec.europa.eu/health/rare_diseases/policy/index_en...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29214165/safety-assessment-and-comparison-of-sodium-selenite-and-bioselenium-obtained-from-yeast-in-mice
#19
Xinghua Wang, Yukun Yang, Hening Zhang, Ju Liu
Detailed safety assessment of sodium selenite and bioselenium (bio-Se) was conducted and the results were compared and discussed for the purpose of assessing safety of bio-Se for use in food applications. In this work, acute toxicity studies, micronucleus test, and sperm aberration study in mice, 30-day feeding test of mice, were conducted to evaluate the toxicity of bio-Se obtained from yeast with different fermentation time (transformative time: one month, three months, and six months), and the results were compared with that of inorganic Se (sodium selenite)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29214145/bitter-orange-citrus-aurantium-l-extract-subchronic-90-day-safety-study-in-rats
#20
N S Deshmukh, S J Stohs, C C Magar, A Kale, B Sowmya
Bitter orange (Citrus aurantium L.) extracts are widely used in dietary supplements and bitter oranges are used in various juices and food products. p-Synephrine, the primary active constituent, comprises approximately 90% of total protoalkaloids. This study, performed per OECD 408 guidance, examined the 90-day subchronic safety/toxicity of an extract standardized to 50% p-synephrine at doses of 100, 300 and 1000 mg/kg/day to male and female rats. No adverse effects were observed with respect to any of the observed parameters of clinical signs, functional observations of sensory reactivity, grip strength and motor activity, ophthalmology, body weights, hematology, food consumption, urinalysis, organ weights, as well as gross and microscopic pathology at termination at any of the doses in either sex...
2017: Toxicology Reports
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