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https://www.readbyqxmd.com/read/29057716/safety-assessment-on-microbial-and-heavy-metal-concentration-in-clarias-gariepinus-african-catfish-cultured-in-treated-wastewater-pond-in-kumasi-ghana
#1
Yeboah-Agyepong Mark, Amoah Philip, Agbo W Nelson, Ashley Muspratt, Samuel Aikins
This study assesses the microbial and heavy metal distribution in African catfish (Clarias gariepinus) cultured in waste stabilization pond, and their subsequent suitability for human consumption. Treated wastewater-fed pond (WFP) was used in the culture of the fish with a non-wastewater fed pond (NWFP), fed with ground and rain water as control. Pond water, sediments and fish tissue (gill, liver, gut and skin) samples from both sources were analyzed for pathogens and heavy metal levels. Escherichia coli populations in the sediments and water from the WFP exceeded the maximum permissible limit by 2-3 log units as expected...
October 23, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29056826/ultra-sensitive-lab-on-a-chip-detection-of-sudan-i-in-food-using-plasmonics-enhanced-diatomaceous-thin-film
#2
Xianming Kong, Kenny Squire, Xinyuan Chong, Alan X Wang
Sudan I is a carcinogenic compound containing an azo group that has been illegally utilized as an adulterant in food products to impart a bright red color to foods. In this paper, we develop a facile lab-on-a-chip device for instant, ultra-sensitive detection of Sudan I from real food samples using plasmonics-enhanced diatomaceous thin film, which can simultaneously perform on-chip separation using thin layer chromatography (TLC) and highly specific sensing using surface-enhanced Raman scattering (SERS) spectroscopy...
September 2017: Food Control
https://www.readbyqxmd.com/read/29056447/comparison-of-ten-different-dna-extraction-procedures-with-respect-to-their-suitability-for-environmental-samples
#3
Ramona Kuhn, Jörg Böllmann, Kathrin Krahl, Isaac Mbir Bryant, Marion Martienssen
DNA extraction for molecular biological applications usually requires target optimized extraction procedures depending on the origin of the samples. For environmental samples, a range of different procedures has been developed. We compared the applicability and efficiency of ten selected DNA extraction methods published in recent literature using four different environmental samples namely: activated sludge from a domestic wastewater treatment plant, river sediment, anaerobic digestion sludge and nitrifying enrichment culture...
October 19, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29056275/current-and-future-applications-of-novel-immunotherapies-in-urological-oncology-a-critical-review-of-the-literature
#4
REVIEW
Berna C Özdemir, Arlene O Siefker-Radtke, Matthew T Campbell, Sumit K Subudhi
CONTEXT: Immunotherapies promote anticancer responses with varying levels of success based on the tumor type. OBJECTIVE: In this narrative review article, we searched the literature regarding immunotherapies in genitourinary malignancies to define the state of the field, explore future applications of immune checkpoint inhibitors, cytokines, vaccines, and cellular therapies in urological oncology and evaluate possible strategies to improve the selection of patients who might benefit from such approaches...
October 19, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29056113/evaluation-of-the-thermo-scientific-rapidfinder%C3%A2-salmonella-species-typhimurium-and-enteritidis-multiplex-pcr-kit
#5
Emma Scopes, Jessica Screen, Katharine Evans, David Crabtree, Annette Hughes, Mikko Kaupinen, Jonathan Flannery, Patrick Bird, M Joseph Benzinger, James Agin, David Goins
The Thermo Scientific RapidFinder™ Salmonella Species, Typhimurium, and Enteritidis Multiplex PCR Kit (candidate method) is a real-time PCR assay for the detection and differentiation of Salmonella spp., and the serovars S. Typhimurium, and S. Enteritidis from poultry, pork, and environmental samples. The method was validated in comparison to the U.S. Department of Agriculture Food Safety and Inspection Service and the U.S. Food and Drug Administration reference methods. Thermo Fisher Scientific (Basingstoke, United Kingdom) tested all matrixes...
October 23, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29055198/dual-competitive-lateral-flow-aptasensor-for-detection-of-aflatoxin-b1-in-food-and-feedstuffs
#6
Chao Zhu, Guilan Zhang, Yafei Huang, Shuming Yang, Shuyue Ren, Zhixian Gao, Ailiang Chen
A novel dual-competitive lateral flow aptasensor (LFA) benefited from aptamer and lateral flow strips was first designed by using aflatoxin B1 (AFB1) as the model target. In this LFA assay, the target AFB1 competed with AFB1-hapten at T line for binding to Cy5-labeled AFB1 aptamer and the complementary strand competed with the target AFB1 for binding to Cy5-labeled AFB1 aptamer at C line. The ratio of their fluorescent intensities at the T line and C line (ST/SC ratio) was employed in order to increase the sensitivity for target AFB1 detection...
October 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29054924/pharmacotherapy-for-patients-with-obesity
#7
REVIEW
Kishore M Gadde, John W Apolzan, Hans-Rudolf Berthoud
BACKGROUND: Although pharmacotherapy is not the cornerstone of obesity treatment, it is a valuable tool that could be considered for patients who have not had adequate benefit from lifestyle interventions or who have difficulty maintaining initial weight loss over longer periods. CONTENT: This review focuses on the role of antiobesity drugs, the mechanisms by which the drugs work, potential pharmacological targets in the neural control of food intake and regulation of body weight, the history of antiobesity drugs, a summary of efficacy and safety data from clinical trials, and the clinical application of pharmacotherapy...
October 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29054139/mc-media-pad-acplus%C3%A2-for-enumeration-of-aerobic-counts-in-a-variety-of-foods
#8
Hajime Teramura, Gail Betts
The MC-Media Pad ACplus™ is a dry, rehydratable film medium for the enumeration of aerobic bacterial colonies.The performance of the method in a variety of foods was compared to that of U.S. reference methods: U.S. Department of Agriculture (USDA) Food Safety and Inspection Service (FSIS) Microbiology Laboratory Guidebook (MLG) Chapter 3.02 "Quantitative Analysis of Bacteria in Foods as Sanitary Indicators" (USDA/FSIS MLG 3.02); Standard Methods for the Examination of Dairy Products (SMEDP) Chapter 6 "Microbiological Count Methods, Standard Plate Count Method" (SMEDP 6); AOAC Official Method(SM)966...
October 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29053606/lung-toxicity-of-condensed-aerosol-from-e-cig-liquids-influence-of-the-flavor-and-the-in-vitro-model-used
#9
Rossella Bengalli, Emanuele Ferri, Massimo Labra, Paride Mantecca
The diffusion of e-cigarette (e-CIG) opens a great scientific and regulatory debate about its safety. The huge number of commercialized devices, e-liquids with almost infinite chemical formulations and the growing market demand for a rapid and efficient toxicity screen system that is able to test all of these references and related aerosols. A consensus on the best protocols for the e-CIG safety assessment is still far to be achieved, since the huge number of variables characterizing these products (e.g., flavoring type and concentration, nicotine concentration, type of the device, including the battery and the atomizer)...
October 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29053003/detoxification-of-cancerogenic-compounds-by-lactic-acid-bacteria-strains
#10
Zhao Lili, Wei Junyan, Zhao Hongfei, Zhu Baoqing, Zhang Bolin
Carcinogens in food are an important issue that threat people's health right now. Lactic acid bacteria (LAB) strains as well-known probiotics have shown numerous perspectives in being used as a good food additive to confront cancerogenic compounds in recent years. Some LAB strains can remove cancerogenic compounds from medium environment via direct physical binding and avoid re-pollution of poisonous secondary metabolites which are generated from degradation of cancerogenic compounds. This article presents a whole overview of the physical-binding of LAB strains to such common cancerogenic compounds existed in food and feed environments as mycotoxins, polycyclic aromatic hydrocarbons (PAHs), heterocyclic amines (HAs) and pthalic acid esters (PAEs)...
October 20, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29052491/an-assessment-of-the-acute-dietary-exposure-to-glyphosate-using-deterministic-and-probabilistic-methods
#11
C L Stephenson, C A Harris, R Clarke
Use of glyphosate in crop production can lead to residues of the active substance and related metabolites in food. Glyphosate has never been considered acutely toxic; however in 2015 the European Food Safety Authority (EFSA) proposed an acute reference dose (ARfD). This differs from the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) who in 2016, in line with their existing position, concluded that an ARfD was not necessary for glyphosate. This paper makes a comprehensive assessment of short-term dietary exposure to glyphosate from potentially-treated crops grown in the EU and imported third country food sources...
October 20, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29052382/-research-progresses-and-formulation-development-of-natural-anti-mildew-agents-based-on-chinese-herbal-medicines
#12
REVIEW
Hai-Wei Wang, Guang-Yao Ying, Zhi-Xin Yang, Mei-Hua Yang, Jia-Jia Liu, Zhuo-Wen Fan, Wei-Jun Kong
Owing to the intrinsic factors and some extrinsic environmental conditions, many foods, agricultural products and Chinese materia medicas (CMMs), if not handled properly in the processes of growth, harvesting, processing and storage, can be easily contaminated by all kinds of molds to produce mycotoxins of serious toxicity, which will not only affect the quality, safety and effectiveness of CMMs, but also result in potential threatens to human and animal's health and life. Therefore, in recent decades, it has become the focus on how to prevent and control the foods, agricultural products and CMMs from being moldy and producing toxicity for scientific preservation...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29052151/hair-mercury-and-risk-assessment-for-consumption-of-contaminated-seafood-in-residents-from-the-coast-of-the-persian-gulf-iran
#13
Narjes Okati, Abbas Esmaili-Sari
The health risks of mercury exposure due to the high consumption of aquatic were assessed for fishermen and non-fishermen families living on the Bandar Abbas, Bushehr, and Mahshahr cities located in the coast of Persian Gulf (Iran). The mean hair mercury concentration of people in Bandar Abbas, Bushehr, and Mahshahr cities was obtained 1.56 ± 0.17, 1.97 ± 0.22, and 5.12 ± 0.3 μg g(-1), respectively. Hair mercury concentration in 8.8% of people exceeded the no observed adverse effects level (NOAEL) of 10 μg g(-1) declared by the World Health Organization (WHO)...
October 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29051989/a-randomized-phase-i-study-to-evaluate-the-safety-tolerability-pharmacokinetics-and-food-effect-of-iguratimod-in-healthy-adult-volunteers
#14
Feng Xiao, Feng Zhang, Ling-Ling Zhang, Wei Wei
OBJECTIVE: The aim of this study was to investigate the safety, maximum tolerated dose and pharmacokinetics (PK) of iguratimod and the effect of food on PK parameters in healthy adult volunteers. METHODS: This phase 1 study consisted of four parts. Part 1 was a single-ascending dose (3.125, 6.25, 12.5, 25, 50, 75 mg) study to assess the maximum tolerated dose and safety of iguratimod. Part 2 was a single-ascending dose study to analyze the pharmacokinetic (PK) parameters of iguratimod; subjects were divided into three groups, with each group receiving iguratimod at a different dose (25, 50 or 75 mg)...
October 19, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29050664/sodium-chloride-does-not-ensure-microbiological-safety-of-foods-cases-and-solutions
#15
Nam Hee Kim, Tae Jin Cho, Min Suk Rhee
Addition of salt or salt-containing water to food is one of the oldest and most effective preservation methods in history; indeed, salt-cured foods are generally recognized as microbiologically safe due to their high salinity. However, a number of microbiological risks remain. The microbiological hazards and risks associated with salt-cured foods must be addressed more in-depth as they are likely to be underestimated by previous studies. This review examined a number of scientific reports and articles about the microbiological safety of salt-cured foods, which included salted, brined, pickled, and/or marinated vegetables, meat, and seafood...
2017: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/29049615/current-trends-in-management-of-submental-liposis-a-pooled-analysis-and-survey
#16
Sagar Patel, Russell Kridel
Importance: Since its approval by the US Food and Drug Administration for treatment of moderate to severe submental liposis in April 2015, deoxycholic acid (Kybella) has received significant media attention as a novel aesthetic treatment. Four phase 3 clinical trials have published data demonstrating the safety and efficacy of the drug compared with placebo; however, no study has juxtaposed the product with submental liposuction. Objective: To evaluate the efficacy of injectable deoxycholic acid in the treatment of isolated submental liposis...
October 19, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29049113/the-us-opioid-crisis-current-federal-and-state-legal-issues
#17
Cobin D Soelberg, Raeford E Brown, Derick Du Vivier, John E Meyer, Banu K Ramachandran
The United States is in the midst of a devastating opioid misuse epidemic leading to over 33,000 deaths per year from both prescription and illegal opioids. Roughly half of these deaths are attributable to prescription opioids. Federal and state governments have only recently begun to grasp the magnitude of this public health crisis. In 2016, the Centers for Disease Control and Prevention released their Guidelines for Prescribing Opioids for Chronic Pain. While not comprehensive in scope, these guidelines attempt to control and regulate opioid prescribing...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29048983/representation-of-women-and-minorities-in-clinical-trials-for-new-molecular-entities-and-original-therapeutic-biologics-approved-by-fda-cder-from-2013-to-2015
#18
Alice Chen, Hilary Wright, Hawi Itana, Merina Elahi, Ayomide Igun, Guoxing Soon, Anne R Pariser, Emmanuel O Fadiran
BACKGROUND: The U.S. Food and Drug Administration (FDA) has made efforts to encourage adequate assessment of women, racial/ethnic minorities, and geriatric participants in clinical trials through regulations and guidance documents. This study surveyed the demographics of clinical trial participants and the presence of efficacy and safety analyses by sex for new drugs approved between 2013 and 2015 by the FDA Center for Drug Evaluation and Research. METHODS: New drug marketing applications submitted to FDA were surveyed for demographic data (sex, race, ethnicity, and age) and the presence of sex-based analyses for efficacy and safety...
October 19, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29048853/-rapid-screening-and-identification-of-food-poisonings-by-ultra-high-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#19
Feng Zhu, Wenliang Ji, Hualiang Liu, Yanbo Jia, Mei Cai, Hao Zhang
A method was developed for the screening and detection of food poisonings by ultra high performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF MS). After extracted by acetonitrile and cleaned-up by QuEChERS, the extract was separated on a Waters Acquity UPLC BEH C18 column (100 mm×2.1 mm, 1.7 μm) with the gradient elution of 0.1% (v/v) formic acid in water and 0.1% (v/v) formic acid in acetonitrile. TOF-MS scan-information dependent acquisition (IDA)-product ion scan was performed in positive electrospray ionization (ESI) mode to acquire high resolution MS and MS/MS spectra in one injection, and rapidly screen 581 target compounds by SCIEX OS software, including 546 pesticides, 24 mycotoxins, 11 rodenticides...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048701/medical-devices-clinical-chemistry-and-clinical-toxicology-devices-classification-of-the-organophosphate-test-system-final-order
#20
(no author information available yet)
The Food and Drug Administration (FDA or we) is classifying the organophosphate test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the organophosphate test system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens...
October 18, 2017: Federal Register
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