keyword
MENU ▼
Read by QxMD icon Read
search

metabolomics

keyword
https://www.readbyqxmd.com/read/28098892/metabolomics-study-on-primary-dysmenorrhea-patients-during-the-luteal-regression-stage-based-on-ultra-performance-liquid-chromatography-coupled-with-quadrupole%C3%A2-time%C3%A2-of%C3%A2-flight-mass-spectrometry
#1
Ling Fang, Caiyun Gu, Xinyu Liu, Jiabin Xie, Zhiguo Hou, Meng Tian, Jia Yin, Aizhu Li, Yubo Li
Primary dysmenorrhea (PD) is a common gynecological disorder which, while not life‑threatening, severely affects the quality of life of women. Most patients with PD suffer ovarian hormone imbalances caused by uterine contraction, which results in dysmenorrhea. PD patients may also suffer from increases in estrogen levels caused by increased levels of prostaglandin synthesis and release during luteal regression and early menstruation. Although PD pathogenesis has been previously reported on, these studies only examined the menstrual period and neglected the importance of the luteal regression stage...
January 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28098796/comparative-metabolite-profiling-of-triterpenoid-saponins-and-flavonoids-in-flower-color-mutations-of-primula-veris-l
#2
Lysanne Apel, Dietmar R Kammerer, Florian C Stintzing, Otmar Spring
Primula veris L. is an important medicinal plant with documented use for the treatment of gout, headache and migraine reaching back to the Middle Ages. Triterpenoid saponins from roots and flowers are used in up-to-date phytotherapeutic treatment of bronchitis and colds due to their expectorant and secretolytic effects. In addition to the wild type plants with yellow petals, a red variant and an intermediate orange form of Primula veris L. have recently been found in a natural habitat. The secondary metabolite profiles of roots, leaves and flowers of these rare variants were investigated and compared with the wild type metabolome...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098776/distinguishing-benign-from-malignant-pancreatic-and-periampullary-lesions-using-combined-use-of-%C3%A2-h-nmr-spectroscopy-and-gas-chromatography-mass-spectrometry
#3
Yarrow J McConnell, Farshad Farshidfar, Aalim M Weljie, Karen A Kopciuk, Elijah Dixon, Chad G Ball, Francis R Sutherland, Hans J Vogel, Oliver F Bathe
Previous work demonstrated that serum metabolomics can distinguish pancreatic cancer from benign disease. However, in the clinic, non-pancreatic periampullary cancers are difficult to distinguish from pancreatic cancer. Therefore, to test the clinical utility of this technology, we determined whether any pancreatic and periampullary adenocarcinoma could be distinguished from benign masses and biliary strictures. Sera from 157 patients with malignant and benign pancreatic and periampullary lesions were analyzed using proton nuclear magnetic resonance (¹H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS)...
January 13, 2017: Metabolites
https://www.readbyqxmd.com/read/28098246/tryptophan-metabolite-activation-of-the-aryl-hydrocarbon-receptor-regulates-il-10-receptor-expression-on-intestinal-epithelia
#4
J M Lanis, E E Alexeev, V F Curtis, D A Kitzenberg, D J Kao, K D Battista, M E Gerich, L E Glover, D J Kominsky, S P Colgan
IL-10 is a potent anti-inflammatory cytokine that inhibits the production of proinflammatory mediators. Signaling by IL-10 occurs through the IL-10 receptor (IL-10R), which is expressed in numerous cell types, including intestinal epithelial cells (IECs), where it is associated with development and maintenance of barrier function. Guided by an unbiased metabolomics screen, we identified tryptophan (Trp) metabolism as a major modifying pathway in interferon-γ (IFNγ)-dominant murine colitis. In parallel, we demonstrated that IFNγ induction of indoleamine 2,3-dioxygenase 1, an enzyme that catalyzes the conversion of Trp to kynurenine (Kyn), induces IL-10R1 expression...
January 18, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28097908/common-and-specific-genes-and-peripheral-biomarkers-in-children-and-adults-with-attention-deficit-hyperactivity-disorder
#5
Cristian Bonvicini, Stephen V Faraone, Catia Scassellati
OBJECTIVES: Elucidating the biological mechanisms involved in Attention-deficit/hyperactivity disorder (ADHD) has been challenging. Relatively unexplored is the fact that these mechanisms can differ with age. METHODS: We present an overview on the major differences between children and adults with ADHD, describing several studies from genomics to metabolomics performed in ADHD children and in adults. A systematic search (up until February, 2016) was conducted. RESULTS: From a PRISMA flow-chart, a total of eligibility 350 studies from genomics and metabolomics were found for cADHD and 91 for aADHD...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28097879/metabolomics-biomarkers-for-tuberculosis-diagnostics-current-status-and-future-objectives
#6
Ilse du Preez, Laneke Luies, Du Toit Loots
Numerous studies have contributed to our current understanding of the complex biology of pulmonary tuberculosis and subsequently provided solutions to its control or eradication. Metabolomics, a newcomer to the Omics research domain, has significantly contributed to this understanding by identifying biomarkers originating from the disease-associated metabolome adaptations of both the microbe and host. These biomarkers have shed light on previously unknown disease mechanisms, many of which have been implemented toward the development of improved diagnostic strategies...
January 18, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28097070/sponge-exhalent-seawater-contains-a-unique-chemical-profile-of-dissolved-organic-matter
#7
Cara L Fiore, Christopher J Freeman, Elizabeth B Kujawinski
Sponges are efficient filter feeders, removing significant portions of particulate and dissolved organic matter (POM, DOM) from the water column. While the assimilation and respiration of POM and DOM by sponges and their abundant microbial symbiont communities have received much attention, there is virtually no information on the impact of sponge holobiont metabolism on the composition of DOM at a molecular-level. We applied untargeted and targeted metabolomics techniques to characterize DOM in seawater samples prior to entering the sponge (inhalant reef water), in samples exiting the sponge (exhalent seawater), and in samples collected just outside the reef area (off reef seawater)...
2017: PeerJ
https://www.readbyqxmd.com/read/28096419/stromal-cues-regulate-the-pancreatic-cancer-epigenome-and-metabolome
#8
Mara H Sherman, Ruth T Yu, Tiffany W Tseng, Cristovao M Sousa, Sihao Liu, Morgan L Truitt, Nanhai He, Ning Ding, Christopher Liddle, Annette R Atkins, Mathias Leblanc, Eric A Collisson, John M Asara, Alec C Kimmelman, Michael Downes, Ronald M Evans
A fibroinflammatory stromal reaction cooperates with oncogenic signaling to influence pancreatic ductal adenocarcinoma (PDAC) initiation, progression, and therapeutic outcome, yet the mechanistic underpinning of this crosstalk remains poorly understood. Here we show that stromal cues elicit an adaptive response in the cancer cell including the rapid mobilization of a transcriptional network implicated in accelerated growth, along with anabolic changes of an altered metabolome. The close overlap of stroma-induced changes in vitro with those previously shown to be regulated by oncogenic Kras in vivo suggests that oncogenic Kras signaling-a hallmark and key driver of PDAC-is contingent on stromal inputs...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096348/transcriptomic-proteomic-and-metabolomic-landscape-of-positional-memory-in-the-caudal-fin-of-zebrafish
#9
Jeremy S Rabinowitz, Aaron M Robitaille, Yuliang Wang, Catherine A Ray, Ryan Thummel, Haiwei Gu, Danijel Djukovic, Daniel Raftery, Jason D Berndt, Randall T Moon
Regeneration requires cells to regulate proliferation and patterning according to their spatial position. Positional memory is a property that enables regenerating cells to recall spatial information from the uninjured tissue. Positional memory is hypothesized to rely on gradients of molecules, few of which have been identified. Here, we quantified the global abundance of transcripts, proteins, and metabolites along the proximodistal axis of caudal fins of uninjured and regenerating adult zebrafish. Using this approach, we uncovered complex overlapping expression patterns for hundreds of molecules involved in diverse cellular functions, including development, bioelectric signaling, and amino acid and lipid metabolism...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096192/integrated-physiological-proteomic-and-metabolomic-analysis-of-uv-stress-responses-and-adaptation-mechanisms-in-pinus-radiata
#10
Jesus Pascual, Maria Jesus Canal, Monica Escandon, Monica Meijon, Wolfram Weckwerth, Luis Valledor
Globally expected changes in environmental conditions, especially the increase of UV irradiation, necessitate extending our knowledge of the mechanisms mediating tree species adaptation to this stress. This is crucial for designing new strategies to maintain future forest productivity. Studies focused on environmentally realistic dosages of UV irradiation in forest species are scarce. Pinus sp. are commercially relevant trees and not much is known about their adaptation to UV. In this work, UV treatment and recovery of Pinus radiata plants with dosages mimicking future scenarios, based on current models of UV radiation, were performed in a time-dependent manner...
January 17, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28095889/evolution-of-gut-microbiota-composition-from-birth-to-24-weeks-in-the-infantmet-cohort
#11
Cian J Hill, Denise B Lynch, Kiera Murphy, Marynka Ulaszewska, Ian B Jeffery, Carol Anne O'Shea, Claire Watkins, Eugene Dempsey, Fulvio Mattivi, Kieran Touhy, R Paul Ross, C Anthony Ryan, Paul W O' Toole, Catherine Stanton
BACKGROUND: The gut is the most extensively studied niche of the human microbiome. The aim of this study was to characterise the initial gut microbiota development of a cohort of breastfed infants (n = 192) from 1 to 24 weeks of age. METHODS: V4-V5 region 16S rRNA amplicon Illumina sequencing and, in parallel, bacteriological culture. The metabolomic profile of infant urine at 4 weeks of age was also examined by LC-MS. RESULTS: Full-term (FT), spontaneous vaginally delivered (SVD) infants' microbiota remained stable at both phylum and genus levels during the 24-week period examined...
January 17, 2017: Microbiome
https://www.readbyqxmd.com/read/28095320/lethal-dysregulation-of-energy-metabolism-during-embryonic-vitamin-e-deficiency
#12
Melissa McDougall, Jaewoo Choi, Hye-Kyeong Kim, Gerd Bobe, J Frederik Stevens, Enrique Cadenas, Robert Tanguay, Maret G Traber
Vitamin E (α-tocopherol, VitE) was discovered in 1922 for its role in preventing embryonic mortality. We investigated the underlying mechanisms causing lethality using targeted metabolomics analyses of zebrafish VitE-deficient embryos over five days of development, which coincided with their increased morbidity and mortality. VitE deficiency resulted in peroxidation of docosahexaenoic acid (DHA), depleting DHA-containing phospholipids, especially phosphatidylcholine, which also caused choline depletion. This increased lipid peroxidation also increased NADPH oxidation, which depleted glucose by shunting it to the pentose phosphate pathway...
January 14, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28095303/gd-dtpa-induced-dynamic-metabonomic-changes-in-rat-biofluids
#13
Chuanling Wan, Youyang Zhan, Rong Xue, Yijie Wu, Xiaojing Li, Fengkui Pei
OBJECTIVES: The purposes of this study were (1) to detect the dynamic metabonomic changes induced by gadopentetate dimeglumine (Gd-DTPA) and (2) to investigate the potential metabolic disturbances associated with the pathogenesis of nephrogenic systemic fibrosis (NSF) at the early stage. METHODS: A nuclear magnetic resonance (NMR)-based metabolomics approach was used to investigate the urinary and serum metabolic changes induced by a single tail vein injection of Gd-DTPA (dosed at 2 and 5mmol/kg body weight) in rats...
January 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28094560/systemic-metabolite-changes-in-wild-type-c57bl-6-mice-fed-black-raspberries
#14
Pan Pan, Chad W Skaer, Hsin-Tzu Wang, Michael A Kreiser, Steven M Stirdivant, Kiyoko Oshima, Yi-Wen Huang, Matthew R Young, Li-Shu Wang
INTRODUCTION: Freeze-dried black raspberries (BRBs) elicit chemopreventive effects against colorectal cancer in humans and in rodents. The objective of this study was to investigate potential BRB-caused metabolite changes using wild-type (WT) C57BL/6 mice. METHODS AND RESULTS: WT mice were fed either control diet or control diet supplemented with 5% BRBs for 8 wk. A nontargeted metabolomic analysis was conducted on colonic mucosa, liver, and fecal specimens collected from both diet groups...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28094274/folivory-elicits-a-strong-defense-reaction-in-catharanthus-roseus-metabolomic-and-transcriptomic-analyses-reveal-distinct-local-and-systemic-responses
#15
Thomas Dugé de Bernonville, Inês Carqueijeiro, Arnaud Lanoue, Florent Lafontaine, Paloma Sánchez Bel, Franziska Liesecke, Karine Musset, Audrey Oudin, Gaëlle Glévarec, Olivier Pichon, Sébastien Besseau, Marc Clastre, Benoit St-Pierre, Victor Flors, Stéphane Maury, Elisabeth Huguet, Sarah E O'Connor, Vincent Courdavault
Plants deploy distinct secondary metabolisms to cope with environment pressure and to face bio-aggressors notably through the production of biologically active alkaloids. This metabolism-type is particularly elaborated in Catharanthus roseus that synthesizes more than a hundred different monoterpene indole alkaloids (MIAs). While the characterization of their biosynthetic pathway now reaches completion, still little is known about the role of MIAs during biotic attacks. As a consequence, we developed a new plant/herbivore interaction system by challenging C...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094011/metabolomics-and-metabolic-diseases-where-do-we-stand
#16
REVIEW
Christopher B Newgard
Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, has undergone a rapid technological evolution in the past two decades. These advances have led to the application of metabolomics to defining predictive biomarkers for incident cardiometabolic diseases and, increasingly, as a blueprint for understanding those diseases' pathophysiologic mechanisms. Progress in this area and challenges for the future are reviewed here.
January 10, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28093455/genomewide-landscape-of-gene-metabolome-associations-in-escherichia-coli
#17
Tobias Fuhrer, Mattia Zampieri, Daniel C Sévin, Uwe Sauer, Nicola Zamboni
Metabolism is one of the best-understood cellular processes whose network topology of enzymatic reactions is determined by an organism's genome. The influence of genes on metabolite levels, however, remains largely unknown, particularly for the many genes encoding non-enzymatic proteins. Serendipitously, genomewide association studies explore the relationship between genetic variants and metabolite levels, but a comprehensive interaction network has remained elusive even for the simplest single-celled organisms...
January 16, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28093124/the-co-feature-ratio-a-novel-method-for-the-measurement-of-chromatographic-and-signal-selectivity-in-lc-ms-based-metabolomics
#18
Albert Elmsjö, Jakob Haglöf, Mikael K R Engskog, Marika Nestor, Torbjörn Arvidsson, Curt Pettersson
Evaluation of analytical procedures, especially in regards to measuring chromatographic and signal selectivity, is highly challenging in untargeted metabolomics. The aim of this study was to suggest a new straightforward approach for a systematic examination of chromatographic and signal selectivity in LC-MS-based metabolomics. By calculating the ratio between each feature and its co-eluting features (the co-features), a measurement of the chromatographic selectivity (i.e. extent of co-elution) as well as the signal selectivity (e...
March 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28093073/application-of-meta-omics-techniques-to-understand-greenhouse-gas-emissions-originating-from-ruminal-metabolism
#19
REVIEW
Robert J Wallace, Timothy J Snelling, Christine A McCartney, Ilma Tapio, Francesco Strozzi
Methane emissions from ruminal fermentation contribute significantly to total anthropological greenhouse gas (GHG) emissions. New meta-omics technologies are beginning to revolutionise our understanding of the rumen microbial community structure, metabolic potential and metabolic activity. Here we explore these developments in relation to GHG emissions. Microbial rumen community analyses based on small subunit ribosomal RNA sequence analysis are not yet predictive of methane emissions from individual animals or treatments...
January 16, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28093044/changes-in-biosynthesis-of-exopolysaccharide-in-lactococcus-lactis-subspecies-cremoris-treated-by-moderate-pulsed-electric-field-treatment
#20
Tetsuro Ohba, Kunihiko Uemura, Hiroshi Nabetani
Metabolome analysis and physicochemical analyses were executed with cell extracts of a Lactococcus lactis subspecies cremoris strain treated by moderate pulsed electric field (PEF) to elucidate the mechanism of enhanced production of exopolysaccharide (EPS) by the treatment. Metabolome analysis by capillary electrophoresis time of flight mass spectrometry annotated 224 metabolites from the cytoplasmic extract of the strain, which, however, showed no significant changes in metabolites related to the EPS production...
January 17, 2017: Bioscience, Biotechnology, and Biochemistry
keyword
keyword
891
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"