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https://www.readbyqxmd.com/read/28440555/striated-duct-adenoma-presenting-with-intra-tumoral-hematoma-and-papillary-thyroid-carcinoma-like-histology
#1
Yohei Ito, Kana Fujii, Takayuki Murase, Kosuke Saida, Yoshihide Okumura, Hisashi Takino, Ayako Masaki, Shintaro Beppu, Daisuke Kawakita, Kei Ijichi, Hiroshi Inagaki
Striated duct adenoma of the salivary gland is a rare benign tumor characterized by unilayered duct epithelium and striations of the tumor cell membranes. To the best of our knowledge, only six cases have been reported in the literature. Here we report an additional case, which was complicated by an intra-tumoral hematoma on clinical presentation and by papillary thyroid carcinoma-like histology on intra-operative frozen section diagnosis. An asymptomatic 78-year-old male presented with a two-year-history of a painless tumor of the left parotid...
April 25, 2017: Pathology International
https://www.readbyqxmd.com/read/28439689/divergent-schwannoma-like-phenotype-in-a-pleomorphic-adenoma
#2
Srinivasa R Chandra, Farah Karim, Yeshwant B Rawal
The schwannoma-like pleomorphic adenoma is a rare histopathological variant of the pleomorphic adenoma. Five previous reports with seven cases exist in English language literature. These tumors present in the parotid gland most commonly. Intraparotid schwannomas of the facial nerve and schwannomas with glandular differentiation have also been reported. A 60-year-old male presented with an asymptomatic swelling over the left angle of the mandible. The swelling had been present for about 12 years with a recent increase in size...
April 24, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28439160/ranula-decompression-using-stitch-and-stab-method-the-aluko-technique
#3
Bayo Aluko-Olokun, Ademola Abayomi Olaitan
BACKGROUND: A ranula is a cystic lesion in the floor of the mouth, formed either as a retention cyst or pseudocyst as a result of extravasation of mucus in the surrounding tissue. It may be treated by micro-marsupialization, marsupialization or excision of lesion with or without the associated salivary gland. Marsupialization is usually achieved by cutting a slit and thereafter stitching the edges such that the epithelium of the exterior becomes continuous with that of the interior of a cyst...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28438298/intravoxel-incoherent-motion-magnetic-resonance-imaging-in-head-and-neck-cancer-a-systematic-review-of-the-diagnostic-and-prognostic-value
#4
REVIEW
Daniel P Noij, Roland M Martens, J Tim Marcus, Remco de Bree, C René Leemans, Jonas A Castelijns, Marcus C de Jong, Pim de Graaf
Intravoxel incoherent motion (IVIM) imaging is increasingly applied in the assessment of head and neck cancer (HNC). Our purpose was to determine the diagnostic and prognostic performance of IVIM in HNC by performing a critical review of the literature. Pubmed and EMBASE were searched until May 2016. Study and patients characteristics, imaging protocol and diagnostic or prognostic outcomes were extracted by 2 independent reviewers. The studied IVIM parameters were diffusion coefficient (D), pseudodiffusion coefficient (D∗), and perfusion fraction (f)...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438292/correlation-of-crtc1-3-maml2-fusion-status-grade-and-survival-in-mucoepidermoid-carcinoma
#5
Andrew C Birkeland, Susan K Foltin, Nicole L Michmerhuizen, Rebecca C Hoesli, Andrew J Rosko, Serena Byrd, Megan Yanik, Jacques E Nor, Carol R Bradford, Mark E Prince, Thomas E Carey, Jonathan B McHugh, Matthew E Spector, J Chad Brenner
OBJECTIVE: Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Tumor stage and grade have historically been important predictors of survival. An oncogenic CRTC1- or CRTC3-MAML2 gene fusion has been identified in a number of MECs. Historically, these gene fusions have been associated with lower grade tumors and better survival. However, reported gene fusion rates and prognosis varies widely across studies, and have not controlled for tumor grade. We sought to identify gene fusion rates and outcomes in our cohort of MEC patients...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28437595/natural-history-and-predictors-of-progression-to-sj%C3%A3-gren-s-syndrome-among-participants-of-the-sicca-registry
#6
Caroline H Shiboski, Alan N Baer, Stephen C Shiboski, Mi Lam, Stephen Challacombe, Hector E Lanfranchi, Morten Schiødt, Penelope Shirlaw, Muthiah Srinivasan, Hisanori Umehara, Frederick B Vivino, Esen Akpek, Vatinee Bunya, Cristina F Vollenweider, John S Greenspan, Troy E Daniels, Lindsey A Criswell
BACKGROUND/PURPOSE: To explore changes in the phenotypic features of Sjoögren's syndrome (SS), and in SS status among participants in the Sjoögren's International Collaborative Clinical Alliance (SICCA) registry over a 2 to 3-year interval. METHODS: All participants in the SICCA registry who were found to have any objective measures of salivary hypofunction, dry eye, focal lymphocytic sialadenitis in minor salivary gland biopsy, or anti-SSA/B antibodies, were recalled over a window of 2 to 3 years after their baseline examinations to repeat all clinical examinations and specimen collections to determine whether there was any change in phenotypic features and in SS status...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28436606/early-and-late-adverse-effects-of-radioiodine-for-pediatric-differentiated-thyroid-cancer
#7
Domenico Albano, Francesco Bertagna, Maria Beatrice Panarotto, Raffaele Giubbini
BACKGROUND: Radioiodine-131 (I131) therapy for differentiated thyroid cancer (DTC) is generally a safe and effective treatment, but it has some potential side effects, which have been well described in adults but less analyzed in children. Our aim was to describe early and late adverse events of radioactive I131 in pediatric patients. METHODS: All consecutive patients ≤18 years treated for DTC in the period 1980-2015 were retrospectively analyzed for early and late side effects of radioiodine...
April 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28434265/adipose-tissue-infiltration-in-minor-salivary-glands-of-patients-with-sj%C3%A3-gren-s-syndrome-lack-of-significant-correlation-with-the-disease-an-image-analysis-of-174-cases
#8
Krisztián Katona, Nelli Farkas, Gábor Sütő, Tamás Tornóczky
Fatty infiltration in minor salivary gland biopsies and its correlation to systemic autoimmune diseases are controversial in the literature. Presence and extent of fatty infiltration in minor salivary glands of 107 Sjögren's syndrome patients and 67 age-matched sicca controls were compared with statistical analyses. No significant difference was found regarding the presence or the extent of fatty infiltration between the two groups. Fatty infiltration seems to be unrelated to Sjögren's syndrome thus its examination in salivary gland biopsy samples cannot improve the diagnostic accuracy of the disease...
April 23, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28434191/the-effect-of-parotid-gland-sparing-imrt-on-salivary-composition-flow-rate-and-xerostomia-measures
#9
Thomas M Richards, Tara Hurley, Lorna Grove, Kevin J Harrington, Guy H Carpenter, Gordon B Proctor, Christopher M Nutting
OBJECTIVES: To describe parotid gland (PG) saliva organic and inorganic composition and flow rate changes, after curative intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) and analyse the relationship between PG saliva analytes and xerostomia measures. METHODS AND MATERIALS: Twenty-six patients recruited to five prospective phase 2 or 3 trials which assessed toxicity and efficacy of IMRT by HNC subsite, provided longitudinal PG salivas. Salivary flow rate, subjective and objective xerostomia measures were prospectively collected and salivas tested for inorganic and organic analytes...
April 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28432120/two-glycosaminoglycan-binding-domains-of-the-mouse-cytomegalovirus-encoded-chemokine-mck-2-are-critical-for-oligomerization-of-the-full-length-protein
#10
Sergio M Pontejo, Philip M Murphy
Chemokines are essential for antimicrobial host defenses and tissue repair. Herpesviruses and poxviruses also encode chemokines, copied from their hosts and repurposed for multiple functions, including immune evasion. The CC chemokine MCK-2 encoded by mouse cytomegalovirus (MCMV) has an atypical structure consisting of a classic chemokine domain N-terminal to a second unique domain, resulting from the splicing of MCMV ORFs m131 and m129. MCK-2 is essential for full MCMV infectivity in macrophages and for persistent infection in the salivary gland...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28431798/absence-of-myoepithelial-cells-correlates-with-invasion-and-metastasis-of-carcinoma-ex-pleomorphic-adenoma
#11
P Ye, Y Gao, T Wei, G-Y Yu, X Peng
Myoepithelial cells (MECs) are implicated in the development and progression of human salivary gland tumours. Here, we investigate the potential role for MECs in invasion and metastasis of carcinoma ex pleomorphic adenoma (CXPA). Tumour tissues from 40 CXPA patients diagnosed between 1960 and 2014 were obtained. Patient samples were divided into two groups (non-invasive tumours, n=10; and frankly invasive tumours, n=30). Each group was further divided into two subgroups (metastatic tumours and non-metastatic tumours)...
April 18, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28431281/dengue-virus-replicates-and-accumulates-in-aedes-aegypti-salivary-glands
#12
Vincent Raquin, Louis Lambrechts
Dengue virus (DENV) is an RNA virus transmitted among humans by mosquito vectors, mainly Aedes aegypti. DENV transmission requires viral dissemination from the mosquito midgut to the salivary glands. During this process the virus undergoes several population bottlenecks, which are stochastic reductions in population size that restrict intra-host viral genetic diversity and limit the efficiency of natural selection. Despite the implications for virus transmission and evolution, DENV replication in salivary glands has not been directly demonstrated...
April 18, 2017: Virology
https://www.readbyqxmd.com/read/28430665/p2x7-receptor-and-nlrp3-inflammasome-activation-in-head-and-neck-cancer
#13
Ju Young Bae, Sang-Woo Lee, Yong-Hwan Shin, Jong-Ho Lee, Jeong Won Jahng, Kyungpyo Park
In this study, we investigated purinergic receptor P2X7 and NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome expressions, and their role in head and neck cancer. We found upregulation of purinergic receptor P2X7 and all NLRP3 inflammasome components in biopsied head and neck squamous cell carcinoma tissues. Similarly, the expression of purinergic receptor P2X7, apoptosis-associated speck-like protein containing CARD, and pro-form caspase 1 in A253 cells derived from epidermoid carcinoma were highly upregulated in comparison to normal Human Salivary Gland cell line...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424677/responses-of-the-housefly-musca-domestica-to-the-hytrosavirus-replication-impacts-on-host-s-vitellogenesis-and-immunity
#14
Henry M Kariithi, Xu Yao, Fahong Yu, Peter E Teal, Chelsea P Verhoeven, Drion G Boucias
Hytrosaviridae family members replicate in the salivary glands (SGs) of their adult dipteran hosts and are transmitted to uninfected hosts via saliva during feeding. Despite inducing similar gross symptoms (SG hypertrophy; SGH), hytrosaviruses (SGHVs) have distinct pathobiologies, including sex-ratio distortions in tsetse flies and refusal of infected housefly females to copulate. Via unknown mechanism(s), SGHV replication in other tissues results in reduced fecundity in tsetse flies and total shutdown of vitellogenesis and sterility in housefly females...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28423973/neurological-involvement-of-igg4-related-disease-description-of-a-case-and-review-of-the-literature
#15
Marco Varrassi, Camilla Gianneramo, Francesco Arrigoni, Paolo Cerrone, Patrizia Sucapane, Carmine Marini, Alessandra Splendiani
IgG4-related disease is a recently discovered pathological entity, histologically characterised by fibrosis and IgG4-positive plasma cell infiltration. This condition may virtually involve every site of the organism, with a various range of clinical presentations. The most commonly affected organ is the pancreatic gland, but it can also involve the biliary tract, salivary and lacrimal glands, kidneys, orbital tissues, lymph nodes, lungs and many others. More recently, IgG4-related disease has been demonstrated to involve, in rare cases, also the central nervous system, with a pattern mainly characterised by hypertrophic pachymeningitis...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28421997/laser-microdissection-coupled-with-rna-seq-reveal-cell-type-and-disease-specific-markers-in-the-salivary-gland-of-sj%C3%A3-gren-s-syndrome-patients
#16
Mayank Tandon, Paola Perez, Peter D Burbelo, Catherine Calkins, Ilias Alevizos
OBJECTIVES: Little is known about the molecular details regarding the contribution of different cell types of the salivary gland to the altered gene expression profile seen in Sjögren's syndrome (SS). METHODS: Using laser microdissection, tissue samples enriched in acini, ducts and inflammatory foci in subjects with and without SS were isolated for RNA-seq analysis. Gene expression profiles were analysed and selected enriched genes were further examined using real time PCR and by immunofluorescence...
April 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28421993/increased-expression-of-interferon-%C3%AE-in-minor-salivary-glands-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-and-its-synergic-effect-with-interferon-%C3%AE-on-salivary-gland-epithelial-cells
#17
You-Jung Ha, Yong Seok Choi, Eun Ha Kang, Jin-Haeng Chung, Seunghee Cha, Yeong Wook Song, Yun Jong Lee
OBJECTIVES: To investigate the expressions of interferon (IFN)-λs and their receptor, IL28RA, in minor salivary glands (MSG) of pSS patients and their effects on the salivary gland cells. METHODS: The expressions of IFN-λs and IL28RA were evaluated in MSG by immunohistochemistry in 15 patients with pSS and in 5 patients with non-SS sicca. Poly(I:C)-induced IL-28A and IL-29 expressions were determined in immortalized human salivary gland acinar (NS-SV-AC) and ductal (NS-SV-DC) cell lines...
April 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28421710/synovial-sarcoma-metastatic-to-the-parotid-gland-a-possible-pitfall-in-salivary-gland-fine-needle-aspiration-cytology-report-of-a-case-with-immunocytochemical-and-fluorescence-in-situ-hybridization-findings
#18
Franco Fulciniti, Jessica Barizzi, Vittoria Martin, Vittorio Tarallo, Stefano Ermanni
We report one case of metastatic synovial sarcoma (SS) to the parotid gland in a 93-year-old male. The patient had undergone upper left pulmonary lobectomy with mediastinal lymphadenectomy for SS of the lung 5 years before. The cytopathologic presentation and the immunocytochemical findings on the FNA sample were suggestive of a spindle cell myoepithelioma, while a SYT rearrangement was identified by a FISH performed on a cytological smear of the lesion. The diagnosis was further confirmed also by positive immunocytochemical expression of TLE1 on a section from the obtained cell block...
April 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28421044/comparative-genomics-of-glossina-palpalis-gambiensis-and-g-morsitans-morsitans-to-reveal-gene-orthologs-involved-in-infection-by-trypanosoma-brucei-gambiense
#19
Illiassou Hamidou Soumana, Bernadette Tchicaya, Stéphanie Rialle, Hugues Parrinello, Anne Geiger
Blood-feeding Glossina palpalis gambiense (Gpg) fly transmits the single-celled eukaryotic parasite Trypanosoma brucei gambiense (Tbg), the second Glossina fly African trypanosome pair being Glossina morsitans/T.brucei rhodesiense. Whatever the T. brucei subspecies, whereas the onset of their developmental program in the zoo-anthropophilic blood feeding flies does unfold in the fly midgut, its completion is taking place in the fly salivary gland where does emerge a low size metacyclic trypomastigote population displaying features that account for its establishment in mammals-human individuals included...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28419576/agreement-between-rapid-on-site-evaluation-and-the-final-cytological-diagnosis-of-salivary-gland-specimens
#20
S Wangsiricharoen, S Lekawanvijit, S Rangdaeng
OBJECTIVE: Rapid on-site evaluation (ROSE) has been shown to be beneficial in determining the adequacy and a preliminary diagnosis in multiple organ systems. However, little is known regarding the diagnostic values and agreement of ROSE compared with a final cytological diagnosis in salivary gland fine needle aspiration (FNA). The aim of the present study was to evaluate agreement and compare accuracy between ROSE and a final cytological diagnosis of salivary gland FNA, using a final histological diagnosis as a gold standard...
April 16, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
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