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https://www.readbyqxmd.com/read/29628048/comprehensive-study-of-rodent-olfactory-tissue-lipid-composition
#1
Anne Marie Le Bon, Nicolas Deprêtre, Estelle Sibille, Stéphanie Cabaret, Stéphane Grégoire, Vanessa Soubeyre, Elodie Masson, Niyazi Acar, Lionel Bretillon, Xavier Grosmaitre, Olivier Berdeaux
The peripheral olfactory tissue (OT) plays a primordial role in the detection and transduction of olfactory information. Recent proteomic and transcriptomic studies have provided valuable insight into proteins and RNAs expressed in this tissue. Paradoxically, there is little information regarding the lipid composition of mammalian OT. To delve further into this issue, using a set of complementary state-of-the-art techniques, we carried out a comprehensive analysis of OT lipid composition in rats and mice fed with standard diets...
April 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29627763/-lipid-raft-aging-in-the-human-frontal-cortex-during-nonpathological-aging-gender-influences-and-potential-implications-in-alzheimer-s-disease
#2
Mario Díaz, Noemí Fabelo, Isidre Ferrer, Raquel Marín
Lipid rafts are highly dynamic membrane domains featured by distinctive biochemical composition and physicochemical properties compared with the surrounding plasma membrane. These microstructures are associated not only with cellular signaling and communication in normal nerve cells but also with pathological processing of amyloid precursor protein in Alzheimer's disease. Using lipid rafts isolated from human frontal cortex in nondemented subjects aging 24 to 85 years, we demonstrate here that lipid structure of lipid rafts undergo significant alterations of specific lipid classes and phospholipid-bound fatty acids as brain cortex correlating with aging...
March 10, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29557170/substantial-decrease-in-plasmalogen-in-the-heart-associated-with-tafazzin-deficiency
#3
Tomohiro Kimura, Atsuko Kimura, Mindong Ren, Bob Berno, Yang Xu, Michael Schlame, Richard M Epand
Tafazzin is the mitochondrial enzyme that catalyzes transacylation between a phospholipid and a lysophospholipid in remodeling. Mutations in tafazzin cause Barth syndrome, a potentially life-threatening disease with the major symptom of cardiomyopathy. In the tafazzin-deficient heart, cardiolipin (CL) acyl chains become abnormally heterogeneous unlike those in the normal heart with a single dominant linoleoyl species; tetralinoleoyl CL. In addition, the amount of CL decreases and monolysocardiolipin (MLCL) accumulates...
March 20, 2018: Biochemistry
https://www.readbyqxmd.com/read/29540574/quantitative-structural-multi-class-lipidomics-using-differential-mobility-electron-impact-excitation-of-ions-from-organics-eieio-mass-spectrometry
#4
Takashi Baba, J Larry Campbell, J C Yves Le Blanc, Paul R S Baker, Kazutaka Ikeda
We report a method for comprehensive structural characterization of lipids in animal tissues using a combination of differential Ion mobility spectrometry (DMS) with electron-impact excitation of ions from organics (EIEIO) mass spectrometry. Singly charged lipid ions in protonated or sodiated forms were dissociated by an electron beam having a kinetic energy of 10 eV in a branched radio-frequency ion trap. We established a comprehensive set of diagnostics to characterize structures of glycerophospholipids, sphingolipids, and acylglycerols, including glycosylated, plasmalogen, and ester forms...
March 14, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29540573/a-novel-assay-for-the-introduction-of-the-vinyl-ether-double-bond-into-plasmalogens-using-pyrene-labelled-substrates
#5
Ernst R Werner, Markus A Keller, Sabrina Sailer, Daniele Seppi, Georg Golderer, Gabriele Werner-Felmayer, Raphael A Zoeller, Katrin Watschinger
Plasmanylethanolamine desaturase (E.C. 1.14.99.19) introduces the 1-prime double bond into plasmalogens, one of the most abundant phospholipids in the human body. This labile membrane enzyme has not been purified and its coding sequence is unknown. Previous assays for this enzyme used radiolabeled substrates followed by multistep processing. We describe here a straight-forward method for the quantification of plasmanylethanolamine desaturase in enzyme incubation mixtures using pyrene-labeled substrates and reversed phase high performance liquid chromatography (HPLC) with fluorescence detection...
March 14, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29530984/cytochrome-c-is-an-oxidative-stress-activated-plasmalogenase-that-cleaves-plasmenylcholine-and-plasmenylethanolamine-at-the-sn-1-vinyl-ether-linkage
#6
Christopher M Jenkins, Kui Yang, Gaoyuan Liu, Sung Ho Moon, Beverly G Dilthey, Richard W Gross
Plasmalogens are phospholipids critical for cell function and signaling that contain a vinyl-ether linkage at the   sn -1 position and are highly enriched in arachidonic acid (AA) at the sn -2 position. However, the enzyme(s) responsible for the cleavage of the vinyl ether linkage in plasmalogens has remained elusive.  Herein, we report that cytochrome c , in the presence of either cardiolipin (CL), O2 and H2 O2 , or oxidized CL and O2 , catalyzes the oxidation of the plasmalogen vinyl ether linkage, promoting its hydrolytic cleavage and resultant production of 2-AA-lysolipids and highly reactive α-hydroxy fatty aldehydes...
March 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29523943/characterization-of-potential-plasma-biomarkers-related-to-cognitive-impairment-by-untargeted-profiling-of-phospholipids-using-the-hilic-esi-it-tof-ms-system
#7
Shuang Song, Ling-Zhi Cheong, Qing-Qing Man, Shao-Jie Pang, Yue-Qi Li, Biao Ren, Jian Zhang
Early diagnosis of neural changes causing cognitive impairment is critical for development of preventive therapies for dementia. Biomarkers currently characterized cannot be extensively applied due to the invasive sampling of cerebrospinal fluid. The other imaging approaches are either expensive or require a high technique. Phospholipids (PLs), which are basic constituents of neurons, might be a key variable in the pathogenesis of cognitive impairment. Changes in plasma PL provide the possibility for development of novel biomarkers with minimal invasion and high patient acceptance...
March 10, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29514688/plasmalogen-lipids-functional-mechanism-and-their-involvement-in-gastrointestinal-cancer
#8
REVIEW
Márcia Cristina Fernandes Messias, Giovana Colozza Mecatti, Denise Gonçalves Priolli, Patrícia de Oliveira Carvalho
The plasmalogens are a class of glycerophospholipids which contain a vinyl-ether and an ester bond at the sn-1 and sn-2 positions, respectively, in the glycerol backbone. They constitute 10 mol% of the total mass of phospholipids in humans, mainly as membrane structure components. Plasmalogens are important for the organization and stability of lipid raft microdomains and cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants and emerging studies suggest that they are involved in cell differentiation and signaling pathways...
March 7, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29500230/ethanolamine-phosphotransferase-1-selenoprotein-i-is-critical-for-the-neural-development-and-maintenance-of-plasmalogen-in-human
#9
Yasuhiro Horibata, Orly Elpeleg, Ayelet Eran, Yoshio Hirabayashi, David Savitzki, Galit Tal, Hanna Mandel, Hiroyuki Sugimoto
Ethanolamine phosphotransferase 1 (EPT1), also known as selenoprotein 1 (SELENOI), is an enzyme that transfers phosphoethanolamine from cytidine diphosphate (CDP)-ethanolamine to lipid acceptors to produce ethanolamine glycerophospholipids such as diacyl-linked phosphatidylethanolamine (PE) and ether-linked plasmalogen (plasmenyl-PE). However, to date there has been no analysis of the metabolomic consequence of the mutation of EPT1 on the concentration of ethanolamine glycerophospholipids in mammalian cells...
March 2, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29487891/enzymatic-measurement-of-ether-phospholipids-in-human-plasma-after-hydrolysis-of-plasma-with-phospholipase-a-1
#10
Shiro Mawatari, Seira Hazeyama, Tomomi Morisaki, Takehiko Fujino
Objectives: Ethanolamine ether phospholipids (ePE) and choline ether phospholipid (ePC) are present in human serum or plasma. Decreases in ether phospholipids (plasmalogens) in serum (plasma) have been reported in several diseases such as Alzheimer's disease, Parkinson's disease, metabolic syndrome, schizophrenia. Therefore, need for assay of ether phospholipids in plasma may increase in the future. Nowadays, measurement of the ether phospholipids in human plasma seem to depend on tandem mass spectrometry (LC/MS/MS), but a system for LC/MS/MS is too expensive for most of ordinary clinical laboratories, moreover, use and maintenance of the system are time consuming...
March 2018: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/29480199/alterations-in-the-plasma-levels-of-specific-choline-phospholipids-in-alzheimer-s-disease-mimic-accelerated-aging
#11
Fabian Dorninger, Ann B Moser, Jianqiu Kou, Christoph Wiesinger, Sonja Forss-Petter, Andreas Gleiss, Margareta Hinterberger, Susanne Jungwirth, Peter Fischer, Johannes Berger
Alzheimer's disease (AD) is the most common neurodegenerative disease and of continuously rising prevalence. The identification of easy-to-measure biomarkers capable to assist in the prediction and early diagnosis of AD is currently a main research goal. Lipid metabolites in peripheral blood of human patients have recently gained major attention in this respect. Here, we analyzed plasma of 174 participants (not demented at baseline; mean age: 75.70±0.44 years) of the Vienna Transdanube Aging (VITA) study, a longitudinal, population-based birth cohort study, at baseline and after 90 months or at diagnosis of probable AD...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29474474/lipidomic-analysis-of-immune-activation-in-equine-leptospirosis-and-leptospira-vaccinated-horses
#12
Paul L Wood, Margaret Steinman, Erdal Erol, Craig Carter, Undine Christmann, Ashutosh Verma
Currently available diagnostic assays for leptospirosis cannot differentiate vaccine from infection serum antibody. Several leptospiral proteins that are upregulated during infection have been described, but their utility as a diagnostic marker is still unclear. In this study, we undertook a lipidomics approach to determine if there are any differences in the serum lipid profiles of horses naturally infected with pathogenic Leptospira spp. and horses vaccinated against a commercially available bacterin. Utilizing a high-resolution mass spectrometry serum lipidomics analytical platform, we demonstrate that cyclic phosphatidic acids, diacylglycerols, and hydroperoxide oxidation products of choline plasmalogens are elevated in the serum of naturally infected as well as vaccinated horses...
2018: PloS One
https://www.readbyqxmd.com/read/29437994/metabolic-profiling-of-visceral-adipose-tissue-from-obese-subjects-with-or-without-metabolic-syndrome
#13
Eleonora Candi, Manfredi Tesauro, Carmine Cardillo, Anna Maria Lena, Francesca Schinzari, Giuseppe Rodia, Giuseppe Sica, Paolo Gentileschi, Valentina Rovella, Margherita Annicchiarico-Petruzzelli, Nicola Di Daniele, Gerry Melino
Obesity represents one of the most complex public health challenges and has recently reached epidemic proportions.  Obesity is also considered to be primarily responsible for the rising prevalence of metabolic syndrome, defined as the coexistence in the same individual of several risk factors for atherosclerosis, including dyslipidaemia, hypertension and hyperglycaemia, as well as for cancer. Additionally, the presence of three of the five risk factors (abdominal obesity, low HDL cholesterol, high triglycerides, high fasting glucose and high blood pressure) characterizes metabolic syndrome, which has serious clinical consequences...
February 8, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29435160/comparison-of-hepatic-and-serum-lipid-signatures-in-hepatocellular-carcinoma-patients-leads-to-the-discovery-of-diagnostic-and-prognostic-biomarkers
#14
Yonghai Lu, Juanjuan Chen, Chong Huang, Ning Li, Li Zou, Sin Eng Chia, Shengsen Chen, Kangkang Yu, Qingxia Ling, Qi Cheng, Mengqi Zhu, Weidong Zhang, Mingquan Chen, Choon Nam Ong
We compared hepatic and serum lipid changes in hepatocellular carcinoma (HCC) patients to have a better understanding of the molecular pathogenesis of this disease and discovery novel lipid biomarkers. Hepatic and serum lipid profiling was conducted in paired liver and serum samples from 50 HCC patients and 24 healthy controls. A total of 20 hepatic and 40 serum lipid signatures were identified, yet there was hardly any significant correlation between them. The results indicated that triglycerides and phosphatidylcholines contributed significantly to altered hepatic lipids, whereas triglycerides and phosphatidylethanolamine-based plasmalogens (PEp) contributed most to altered serum lipids...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29413957/2-chlorohexadecanoic-acid-induces-er-stress-and-mitochondrial-dysfunction-in-brain-microvascular-endothelial-cells
#15
Eva Bernhart, Nora Kogelnik, Jürgen Prasch, Benjamin Gottschalk, Madeleine Goeritzer, Maria Rosa Depaoli, Helga Reicher, Christoph Nusshold, Ioanna Plastira, Astrid Hammer, Günter Fauler, Roland Malli, Wolfgang F Graier, Ernst Malle, Wolfgang Sattler
Peripheral leukocytes induce blood-brain barrier (BBB) dysfunction through the release of cytotoxic mediators. These include hypochlorous acid (HOCl) that is formed via the myeloperoxidase-H2O2-chloride system of activated phagocytes. HOCl targets the endogenous pool of ether phospholipids (plasmalogens) generating chlorinated inflammatory mediators like e.g. 2-chlorohexadecanal and its conversion product 2-chlorohexadecanoic acid (2-ClHA). In the cerebrovasculature these compounds inflict damage to brain microvascular endothelial cells (BMVEC) that form the morphological basis of the BBB...
January 5, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413575/analysis-of-phosphatidylethanolamine-phosphatidylcholine-and-plasmalogen-molecular-species-in-food-lipids-using-an-improved-2d-high-performance-liquid-chromatography-system
#16
Ryosuke Takahashi, Makoto Nakaya, Miyako Kotaniguchi, Aiko Shojo, Shinichi Kitamura
Phospholipids are an important class of lipids in cell membranes and food. Several high-performance liquid chromatography (HPLC) methods have been developed to analyze phospholipids at the molecular species level. We developed a two-dimensional HPLC system with a charged aerosol detector and mass spectrometry (MS) to analyze phosphatidylethanolamine (PE), phosphatidylcholine (PC), and their plasmalogens (pls) extracted from food materials. Accordingly, the phospholipid molecular species can be analyzed in a single step despite using smaller samples...
January 29, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29407877/association-of-cholesterol-efflux-capacity-with-plasmalogen-levels-of-high-density-lipoprotein-a-cross-sectional-study-in-chronic-kidney-disease-patients
#17
Ryouta Maeba, Ken-Ichiro Kojima, Michito Nagura, Aya Komori, Megumi Nishimukai, Tomoki Okazaki, Shunya Uchida
BACKGROUND AND AIM: Current research suggests that dysfunctional high-density lipoprotein (HDL) with low cholesterol efflux capacity may accelerate atherosclerosis, particularly in chronic kidney disease (CKD). We previously reported that serum levels of plasmalogens closely correlated with HDL concentration, and could serve as a novel biomarker for atherosclerosis. In the present study, we analyzed the association of cholesterol efflux capacity of HDL with clinical and biochemical parameters, including plasmalogens, in CKD patients...
February 1, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29378164/the-chlorinated-lipidome-originating-from-myeloperoxidase-derived-hocl-targeting-plasmalogens-metabolism-clearance-and-biological-properties
#18
REVIEW
Elisa N D Palladino, Celine L Hartman, Carolyn J Albert, David A Ford
Myeloperoxidase produces the two-electron oxidant HOCl, which targets plasmalogen phospholipids liberating 2-chlorofatty aldehyde. 2-Chlorofatty aldehyde has four known fates: 1) oxidation to 2-chlorofatty acid; 2) reduction to 2-chlorofatty alcohol; 3) Schiff base adduct formation with proteins and amines; and 4) reactivity with glutathione through nucleophilic attack of the α-chlorinated carbon. 2-Chlorofatty acid does not undergo conventional fatty acid β-oxidation due to the presence of the α-chlorinated carbon; however, 2-chlorofatty acid does undergo sequential ω-oxidation and β-oxidation from the ω-end, ultimately resulting in 2-chloroadipic acid urinary excretion...
January 26, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29355561/ameliorating-effects-of-d-47-a-newly-developed-compound-on-lipid-metabolism-in-an-animal-model-of-familial-hypercholesterolemia-whhlmi-rabbits
#19
Shohei Tamura, Yui Koike, Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Ryosuke Nagasaka, Tetsuto Tsunoda, Motoo Tori, Kazuo Ogawa, Takeshi Bamba, Masashi Shiomi
Improvements induced in lipid metabolism in the liver by D-47, a newly developed compound, were examined herein. WHHLMI rabbits, an animal model of hypercholesterolemia and coronary atherosclerosis, was fed D-47-supplemented chow for 5 weeks at a dose of 30mg/kg. Lipid concentration were assayed using enzymatic methods. Plasma lipoproteins were fractionated with an ultracentrifuge. mRNA expression was analyzed with real-time PCR. Lipidome analyses of lipoproteins were performed using supercritical fluid chromatography mass spectrometry...
March 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29337053/oral-ingestion-of-plasmalogens-can-attenuate-the-lps-induced-memory-loss-and-microglial-activation
#20
Md Shamim Hossain, Ayako Tajima, Satoshi Kotoura, Toshihiko Katafuchi
Plasmalogens (Pls) are the special phospholipids which were reported to be reduced in brain and blood samples of Alzheimer's disease (AD) patients, suggested a possibility that an oral ingestion of Pls may prevent the disease progression. Interestingly, the clinical study showed that the daily oral ingestion of Pls among the mild AD patients improved cognition. However, it is unknown of whether the oral ingestion of Pls inhibits the AD like changes in brain e.g., glial activation and accumulation of amyloid beta (Aβ) proteins...
February 19, 2018: Biochemical and Biophysical Research Communications
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