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https://www.readbyqxmd.com/read/28202633/regional-changes-in-cns-and-retinal-glycerophospholipid-profiles-with-age-a-molecular-blueprint
#1
Blake R Hopiavuori, Martin-Paul Agbaga, Richard S Brush, Michael T Sullivan, William E Sonntag, Robert E Anderson
We present herein a quantitative molecular blueprint of the three major glycerophospholipid (GPL) classes phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylethanolamine (PE) in retina and six regions of the brain in C57Bl6 mice at 2, 10, and 26 months of age. We found an age-related increase in molecular species containing saturated and monoenoic fatty acids and an overall decrease in the longer chain polyunsaturated fatty acid (PUFA) molecular species across brain regions, with loss of docosahexaenoic acid (DHA)-containing molecular species as the most consistent and dramatic finding...
February 15, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28185807/specific-circulating-phospholipids-acylcarnitines-amino-acids-and-biogenic-amines-are-aerobic-exercise-markers
#2
Thomas K Felder, Susanne Ring-Dimitriou, Simon Auer, Selma M Soyal, Ludmilla Kedenko, Mark Rinnerthaler, Janne Cadamuro, Elisabeth Haschke-Becher, Elmar Aigner, Bernhard Paulweber, Wolfgang Patsch
OBJECTIVES: Regular aerobic exercise provides beneficial effects on human health and reduces all-cause mortality. Aerobic exercise has profound metabolic effects, and specific metabolites may reflect physiological changes. We aimed to identify endogenous metabolites that distinguish the trained from the untrained state to increase the spectrum of analytes amenable for hypothesis testing and to expand understanding of putative beneficial pathways. DESIGN: Cross sectional laboratory repeated measures study...
January 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28167298/diabetes-alters-myelin-lipid-profile-in-rat-cerebral-cortex-protective-effects-of-dihydroprogesterone
#3
Gaia Cermenati, Silvia Giatti, Matteo Audano, Marzia Pesaresi, Roberto Spezzano, Donatella Caruso, Nico Mitro, Roberto Cosimo Melcangi
Due to the emerging association of diabetes with several psychiatric and neurodegenerative events, the evaluation of the effects of this pathology on the brain function has now a high priority in biomedical research. In particular, the effects of diabetes on myelin compartment have been poorly taken into consideration. To this purpose, we performed a deep lipidomic analysis of cortical myelin in the streptozotocin-induced diabetic rat model. In male rats three months of diabetes induced an extensive alterations in levels of phosphatidylcholines and phosphatidylethanolamines (the main species present in myelin membranes), plasmalogens as well as phosphatidylinositols and phosphatidylserines...
February 3, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28152600/unbiased-metabolite-profiling-of-schizophrenia-fibroblasts-under-stressful-perturbations-reveals-dysregulation-of-plasmalogens-and-phosphatidylcholines
#4
Joanne H Huang, Hyoungjun Park, Jonathan Iaconelli, Shaunna S Berkovitch, Bradley Watmuff, Donna McPhie, Dost Öngür, Bruce M Cohen, Clary B Clish, Rakesh Karmacharya
We undertook an unbiased metabolite profiling of fibroblasts from schizophrenia patients and healthy controls to identify metabolites and pathways that are dysregulated in disease, seeking to gain new insights into the disease biology of schizophrenia and to discover potential disease-related biomarkers. We measured polar and nonpolar metabolites in the fibroblasts under normal conditions and under two stressful physiological perturbations: growth in low-glucose media and exposure to the steroid hormone dexamethasone...
February 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28129423/novel-pex11b-mutations-extend-the-peroxisome-biogenesis-disorder-14b-phenotypic-spectrum-and-underscore-congenital-cataract-as-an-early-feature
#5
Rachel L Taylor, Mark T Handley, Sarah Waller, Christopher Campbell, Jill Urquhart, Alison M Meynert, Jamie M Ellingford, Deirdre Donnelly, Gisela Wilcox, I Chris Lloyd, Helen Mundy, David R FitzPatrick, Charu Deshpande, Jill Clayton-Smith, Graeme C Black
Purpose: Peroxisomes perform complex metabolic and catabolic functions essential for normal growth and development. Mutations in 14 genes cause a spectrum of peroxisomal disease in humans. Most recently, PEX11B was associated with an atypical peroxisome biogenesis disorder (PBD) in a single individual. In this study, we identify further PEX11B cases and delineate associated phenotypes. Methods: Probands from three families underwent next generation sequencing (NGS) for diagnosis of a multisystem developmental disorder...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28108526/vaps-and-acbd5-tether-peroxisomes-to-the-er-for-peroxisome-maintenance-and-lipid-homeostasis
#6
Rong Hua, Derrick Cheng, Étienne Coyaud, Spencer Freeman, Erminia Di Pietro, Yuqing Wang, Adriano Vissa, Christopher M Yip, Gregory D Fairn, Nancy Braverman, John H Brumell, William S Trimble, Brian Raught, Peter K Kim
Lipid exchange between the endoplasmic reticulum (ER) and peroxisomes is necessary for the synthesis and catabolism of lipids, the trafficking of cholesterol, and peroxisome biogenesis in mammalian cells. However, how lipids are exchanged between these two organelles is not understood. In this study, we report that the ER-resident VAMP-associated proteins A and B (VAPA and VAPB) interact with the peroxisomal membrane protein acyl-CoA binding domain containing 5 (ACBD5) and that this interaction is required to tether the two organelles together, thereby facilitating the lipid exchange between them...
February 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28089346/detection-of-unusual-very-long-chain-fatty-acid-and-ether-lipid-derivatives-in-the-fibroblasts-and-plasma-of-patients-with-peroxisomal-diseases-using-liquid-chromatography-mass-spectrometry
#7
Shigeo Takashima, Kayoko Toyoshi, Takahiro Itoh, Naomi Kajiwara, Ayako Honda, Akiko Ohba, Shoko Takemoto, Satoshi Yoshida, Nobuyuki Shimozawa
Metabolic changes occur in patients with peroxisomal diseases owing to impairments in the genes involved in peroxisome function. For diagnostic purposes, saturated very-long-chain fatty acids (VLCFAs) such as C24:0 and C26:0, phytanic acid, pristanic acid, and plasmalogens are often measured as metabolic hallmarks. As the direct pathology of peroxisomal disease is yet to be fully elucidated, we sought to explore the fatty acid species that accumulate in patients with peroxisomal diseases. We developed a method for detecting a range of fatty acids implicated in peroxisomal diseases such as Zellweger syndrome (ZS) and X-linked adrenoleukodystrophy (X-ALD)...
January 7, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28073164/protective-role-of-endogenous-plasmalogens-against-hepatic-steatosis-and-steatohepatitis
#8
Jung Eun Jang, Han-Sol Park, Hyun Ju Yoo, In-Jeoung Baek, Ji Eun Yoon, Myoung Seok Ko, Ah-Ram Kim, Hyoun Sik Kim, Hye-Sun Park, Seung Eun Lee, Seung-Whan Kim, Su Jung Kim, Jaechan Leem, Yu Mi Kang, Min Kyo Jung, Chan-Gi Pack, Chong Jai Kim, Chang Ohk Sung, In-Kyu Lee, Joong-Yeol Park, José C Fernández-Checa, Eun Hee Koh, Ki-Up Lee
: Free cholesterol (FC) accumulation in the liver is an important pathogenic mechanism of nonalcoholic steatohepatitis (NASH). Plasmalogens, key structural components of the cell membrane, act as endogenous antioxidants and are primarily synthesized in the liver. However, the role of hepatic plasmalogens in metabolic liver disease is unclear. In this study, we found that hepatic levels of docosahexaenoic acid (DHA)-containing plasmalogens, expression of glyceronephosphate O-acyltransferase (Gnpat, the rate-limiting enzyme in plasmalogen biosynthesis), and expression of Pparα were lower in mice with NASH caused by accumulation of free cholesterol (FC) in the liver...
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28052980/metabolites-associated-with-lean-mass-and-adiposity-in-older-black-men
#9
Rachel A Murphy, Steven C Moore, Mary Playdon, Osorio Meirelles, Anne B Newman, Iva Milijkovic, Stephen B Kritchevsky, Ann Schwartz, Bret H Goodpaster, Joshua Sampson, Peggy Cawthon, Eleanor M Simonsick, Robert E Gerszten, Clary B Clish, Tamara B Harris
To identify biomarkers of body mass index, body fat, trunk fat, and appendicular lean mass, nontargeted metabolomics was performed in plasma from 319 black men in the Health, Aging and Body Composition study (median age 72 years, median body mass index 26.8 kg/m(2)). Body mass index was calculated from measured height and weight; percent fat, percent trunk fat, and appendicular lean mass were measured with dual-energy x-ray absorptiometry. Pearson partial correlations between body composition measures and metabolites were adjusted for age, study site, and smoking...
January 3, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28013369/peroxisomal-abnormalities-in-the-immortalized-human-hepatocyte-ihh-cell-line
#10
Femke C C Klouwer, Janet Koster, Sacha Ferdinandusse, Hans R Waterham
The immortalized human hepatocyte (IHH) cell line is increasingly used for studies related to liver metabolism, including hepatic glucose, lipid, lipoprotein and triglyceride metabolism, and the effect of therapeutic interventions. To determine whether the IHH cell line is a good model to investigate hepatic peroxisomal metabolism, we measured several peroxisomal parameters in IHH cells and, for comparison, HepG2 cells and primary skin fibroblasts. This revealed a marked plasmalogen deficiency and a deficient fatty acid α-oxidation in the IHH cells, due to a defect of PEX7, a cytosolic receptor protein required for peroxisomal import of a subset of peroxisomal proteins...
December 24, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28007964/peroxisome-proliferator-activated-receptor-%C3%AE-accelerates-%C3%AE-chlorofatty-acid-catabolism
#11
Elisa N D Palladino, Wen-Yi Wang, Carolyn J Albert, Cédric Langhi, Ángel Baldán, David A Ford
α-Chlorofatty aldehydes are generated from myeloperoxidase-derived HOCl targeting plasmalogens, and are subsequently oxidized to α-chlorofatty acids (α-ClFAs). The catabolic pathway for α-ClFA is initiated by ω-oxidation. Here, we examine PPAR-α activation as a mechanism to increase α-ClFA catabolism. Pretreating both HepG2 cells and primary mouse hepatocytes with the PPAR-α agonist, pirinixic acid (Wy 14643), increased the production of α-chlorodicarboxylic acids (α-ClDCAs) in cells treated with exogenous α-ClFA...
February 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28001010/adipocyte-lipopolysaccharide-binding-protein-lbp-is-linked-to-a-specific-lipidomic-signature
#12
José María Moreno-Navarrete, Mariona Jové, Teresa Padró, Jordi Boada, Francisco Ortega, Wifredo Ricart, Reinald Pamplona, Lina Badimón, Manuel Portero-Otín, José Manuel Fernández-Real
OBJECTIVE: Lipopolysaccharide binding protein (LBP) is part of a family of structurally and functionally related lipid transfer proteins. This study aimed to investigate the associations of LBP with the lipid composition of human adipose tissue. METHODS: Lipidomic analysis was performed in whole adipose tissue. To validate the associations found, LBP was knocked down (KD) in 3T3-L1 adipocytes, and lipidomic profile was evaluated by nontargeted lipidomics. RESULTS: LBP gene expression was negatively associated with phosphatidylcholine, phosphatidylserine, and sphingomyelin relative abundance in vivo...
December 21, 2016: Obesity
https://www.readbyqxmd.com/read/27941306/peroxisome-biogenesis-and-human-peroxisome-deficiency-disorders
#13
Yukio Fujiki
Peroxisome is a single-membrane-bounded ubiquitous organelle containing a hundred different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. To investigate peroxisome biogenesis and human peroxisome biogenesis disorders (PBDs) including Zellweger syndrome, more than a dozen different complementation groups of Chinese hamster ovary (CHO) cell mutants impaired in peroxisome biogenesis are isolated as a model experimental system...
2016: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/27888687/accurate-quantitation-of-choline-and-ethanolamine-plasmalogen-molecular-species-in-human-plasma-by-liquid-chromatography-tandem-mass-spectrometry
#14
Yurika Otoki, Shunji Kato, Fumiko Kimura, Katsutoshi Furukawa, Shinji Yamashita, Hiroyuki Arai, Teruo Miyazawa, Kiyotaka Nakagawa
Concentration of both choline plasmalogen (PC-Pls) and ethanolamine Pls (PE-Pls) in human plasma/serum has been getting attention to, since certain patients including those with neurodegenerative disorders, have been reported to exhibit reduced levels of specific Pls species. However, despite using liquid chromatography-tandem mass spectrometry (LC-MS/MS), accurate quantitation of Pls is still difficult because of less product ion from PC-Pls and quantitative issues (e.g., extraction recoveries and matrix effects)...
February 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27862481/correlation-of-lipidomic-composition-of-cell-lines-and-tissues-of-breast-cancer-patients-using-hydrophilic-interaction-liquid-chromatography-electrospray-ionization-mass-spectrometry-and-multivariate-data-analysis
#15
Eva Cífková, Miroslav Lísa, Roman Hrstka, David Vrána, Jiří Gatěk, Bohuslav Melichar, Michal Holčapek
RATIONALE: The goal of this work is the comparison of differences in the lipidomic compositions of human cell lines derived from normal and cancerous breast tissues, and tumor vs. normal tissues obtained after the surgery of breast cancer patients. METHODS: Hydrophilic interaction liquid chromatography/electrospray ionization mass spectrometry (HILIC/ESI-MS) using the single internal standard approach and response factors is used for the determination of relative abundances of individual lipid species from five lipid classes in total lipid extracts of cell lines and tissues...
February 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27836780/oxidative-stress-leads-to-reduction-of-plasmalogen-serving-as-a-novel-biomarker-for-systemic-lupus-erythematosus
#16
Changfeng Hu, Jia Zhou, Shasha Yang, Haichang Li, Chunyan Wang, Xiaoling Fang, Yongsheng Fan, Jida Zhang, Xianlin Han, Chengping Wen
Oxidative stress is elevated in systemic lupus erythematosus (SLE) patients, and associated extensively with SLE pathogenesis. However, no common indicators of oxidative stress are yet in routine clinical use because of their instability, nonspecificity, and non-representation of all SLE symptoms. Moreover, the method for reproducible analysis of reactive oxygen species is still lacking. Lipids and their metabolites are essential components of biological systems, many of which serve as molecular targets of oxidative stress and play crucial roles in signaling, inflammation, and immune responses...
December 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27833852/molecular-cloning-heterologous-expression-and-enzymatic-characterization-of-lysoplasmalogen-specific-phospholipase-d-from-thermocrispum-sp
#17
Yusaku Matsumoto, Nana Kashiwabara, Takayuki Oyama, Kazutaka Murayama, Hideyuki Matsumoto, Shin-Ich Sakasegawa, Daisuke Sugimori
: Lysoplasmalogen (LyPls)-specific phospholipase D (LyPls-PLD) is an enzyme that catalyses the hydrolytic cleavage of the phosphoester bond of LyPls, releasing ethanolamine or choline, and 1-(1-alkenyl)-sn-glycero-3-phosphate (lysoplasmenic acid). Little is known about LyPls-PLD and metabolic pathways of plasmalogen (Pls). Reportedly, Pls levels in human serum/plasma correlate with several diseases such as Alzheimer's disease and arteriosclerosis as well as a variety of biological processes including apoptosis and cell signaling...
November 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27825781/familial-risk-for-bipolar-disorder-is-not-associated-with-impaired-peroxisomal-function-dissociation-from-docosahexaenoic-acid-deficits
#18
Robert K McNamara, Ann B Moser, Richard I Jones, Ronald Jandacek, L Rodrigo Patino, Jeffrey R Strawn, Stephen M Strakowski, Melissa P DelBello
Bipolar I disorder is associated with deficits in the long-chain omega-3 fatty acid docosahexaenoic acid (DHA, 22:6n-3). The final biosynthesis of DHA is mediated by peroxisomes, and some heritable peroxisomal disorders are associated with DHA deficits and progressive psychopathology. The present cross-sectional study investigated whether medication-free asymptomatic and symptomatic youth with familial risk for bipolar I disorder exhibit impaired peroxisomal function using a comprehensive diagnostic blood panel...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27814884/corrigendum-to-plasmalogen-modulation-attenuates-atherosclerosis-in-apoe-and-apoe-gpx1-deficient-mice-atherosclerosis-243-2-2015-598-608
#19
Aliki A Rasmiena, Christopher K Barlow, Nada Stefanovic, Kevin Huynh, Ricardo Tan, Arpeeta Sharma, Dedreia Tull, Judy B de Haan, Peter J Meikle
No abstract text is available yet for this article.
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27788153/increased-%C3%AF-6-containing-phospholipids-and-primary-%C3%AF-6-oxidation-products-in-the-brain-tissue-of-rats-on-an-%C3%AF-3-deficient-diet
#20
Paul H Axelsen, Robert C Murphy, Miki Igarashi, Stanley I Rapoport
Polyunsaturated fatty acyl (PUFA) chains in both the ω3 and ω6 series are essential for normal animal brain development, and cannot be interconverted to compensate for a dietary deficiency of one or the other. Paradoxically, a dietary ω3-PUFA deficiency leads to the accumulation of docosapentaenoate (DPA, 22:5ω6), an ω6-PUFA chain that is normally scarce in the brain. We applied a high-precision LC/MS method to characterize the distribution of DPA chains across phospholipid headgroup classes, the fatty acyl chains with which they were paired, and the extent to which they were oxidatively damaged in the cortical brain of rats on an ω3-deficient diet...
2016: PloS One
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