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https://www.readbyqxmd.com/read/29437994/metabolic-profiling-of-visceral-adipose-tissue-from-obese-subjects-with-or-without-metabolic-syndrome
#1
Eleonora Candi, Manfredi Tesauro, Carmine Cardillo, Anna Maria Lena, Francesca Schinzari, Giuseppe Rodia, Giuseppe Sica, Paolo Gentileschi, Valentina Rovella, Margherita Annicchiarico-Petruzzelli, Nicola Di Daniele, Gerry Melino
Obesity represents one of the most complex public health challenges and has recently reached epidemic proportions.  Obesity is also considered to be primarily responsible for the rising prevalence of metabolic syndrome, defined as the coexistence in the same individual of several risk factors for atherosclerosis, including dyslipidaemia, hypertension and hyperglycaemia, as well as for cancer. Additionally, the presence of three of the five risk factors (abdominal obesity, low HDL cholesterol, high triglycerides, high fasting glucose and high blood pressure) characterizes metabolic syndrome, which has serious clinical consequences...
February 8, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29435160/comparison-of-hepatic-and-serum-lipid-signatures-in-hepatocellular-carcinoma-patients-leads-to-the-discovery-of-diagnostic-and-prognostic-biomarkers
#2
Yonghai Lu, Juanjuan Chen, Chong Huang, Ning Li, Li Zou, Sin Eng Chia, Shengsen Chen, Kangkang Yu, Qingxia Ling, Qi Cheng, Mengqi Zhu, Weidong Zhang, Mingquan Chen, Choon Nam Ong
We compared hepatic and serum lipid changes in hepatocellular carcinoma (HCC) patients to have a better understanding of the molecular pathogenesis of this disease and discovery novel lipid biomarkers. Hepatic and serum lipid profiling was conducted in paired liver and serum samples from 50 HCC patients and 24 healthy controls. A total of 20 hepatic and 40 serum lipid signatures were identified, yet there was hardly any significant correlation between them. The results indicated that triglycerides and phosphatidylcholines contributed significantly to altered hepatic lipids, whereas triglycerides and phosphatidylethanolamine-based plasmalogens (PEp) contributed most to altered serum lipids...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29413957/2-chlorohexadecanoic-acid-induces-er-stress-and-mitochondrial-dysfunction-in-brain-microvascular-endothelial-cells
#3
Eva Bernhart, Nora Kogelnik, Jürgen Prasch, Benjamin Gottschalk, Madeleine Goeritzer, Maria Rosa Depaoli, Helga Reicher, Christoph Nusshold, Ioanna Plastira, Astrid Hammer, Günter Fauler, Roland Malli, Wolfgang F Graier, Ernst Malle, Wolfgang Sattler
Peripheral leukocytes induce blood-brain barrier (BBB) dysfunction through the release of cytotoxic mediators. These include hypochlorous acid (HOCl) that is formed via the myeloperoxidase-H2O2-chloride system of activated phagocytes. HOCl targets the endogenous pool of ether phospholipids (plasmalogens) generating chlorinated inflammatory mediators like e.g. 2-chlorohexadecanal and its conversion product 2-chlorohexadecanoic acid (2-ClHA). In the cerebrovasculature these compounds inflict damage to brain microvascular endothelial cells (BMVEC) that form the morphological basis of the BBB...
January 5, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413575/analysis-of-phosphatidylethanolamine-phosphatidylcholine-and-plasmalogen-molecular-species-in-food-lipids-using-an-improved-2d-high-performance-liquid-chromatography-system
#4
Ryosuke Takahashi, Makoto Nakaya, Miyako Kotaniguchi, Aiko Shojo, Shinichi Kitamura
Phospholipids are an important class of lipids in cell membranes and food. Several high-performance liquid chromatography (HPLC) methods have been developed to analyze phospholipids at the molecular species level. We developed a two-dimensional HPLC system with a charged aerosol detector and mass spectrometry (MS) to analyze phosphatidylethanolamine (PE), phosphatidylcholine (PC), and their plasmalogens (pls) extracted from food materials. Accordingly, the phospholipid molecular species can be analyzed in a single step despite using smaller samples...
January 29, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29407877/association-of-cholesterol-efflux-capacity-with-plasmalogen-levels-of-high-density-lipoprotein-a-cross-sectional-study-in-chronic-kidney-disease-patients
#5
Ryouta Maeba, Ken-Ichiro Kojima, Michito Nagura, Aya Komori, Megumi Nishimukai, Tomoki Okazaki, Shunya Uchida
BACKGROUND AND AIM: Current research suggests that dysfunctional high-density lipoprotein (HDL) with low cholesterol efflux capacity may accelerate atherosclerosis, particularly in chronic kidney disease (CKD). We previously reported that serum levels of plasmalogens closely correlated with HDL concentration, and could serve as a novel biomarker for atherosclerosis. In the present study, we analyzed the association of cholesterol efflux capacity of HDL with clinical and biochemical parameters, including plasmalogens, in CKD patients...
February 1, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29378164/the-chlorinated-lipidome-originating-from-myeloperoxidase-derived-hocl-targeting-plasmalogens-metabolism-clearance-and-biological-properties
#6
REVIEW
Elisa N D Palladino, Celine L Hartman, Carolyn J Albert, David A Ford
Myeloperoxidase produces the two-electron oxidant HOCl, which targets plasmalogen phospholipids liberating 2-chlorofatty aldehyde. 2-Chlorofatty aldehyde has four known fates: 1) oxidation to 2-chlorofatty acid; 2) reduction to 2-chlorofatty alcohol; 3) Schiff base adduct formation with proteins and amines; and 4) reactivity with glutathione through nucleophilic attack of the α-chlorinated carbon. 2-Chlorofatty acid does not undergo conventional fatty acid β-oxidation due to the presence of the α-chlorinated carbon; however, 2-chlorofatty acid does undergo sequential ω-oxidation and β-oxidation from the ω-end, ultimately resulting in 2-chloroadipic acid urinary excretion...
January 26, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29355561/ameliorating-effects-of-d-47-a-newly-developed-compound-on-lipid-metabolism-in-an-animal-model-of-familial-hypercholesterolemia-whhlmi-rabbits
#7
Shohei Tamura, Yui Koike, Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Ryosuke Nagasaka, Tetsuto Tsunoda, Motoo Tori, Kazuo Ogawa, Takeshi Bamba, Masashi Shiomi
Improvements induced in lipid metabolism in the liver by D-47, a newly developed compound, were examined herein. WHHLMI rabbits, an animal model of hypercholesterolemia and coronary atherosclerosis, was fed D-47-supplemented chow for 5 weeks at a dose of 30mg/kg. Lipid concentration were assayed using enzymatic methods. Plasma lipoproteins were fractionated with an ultracentrifuge. mRNA expression was analyzed with real-time PCR. Lipidome analyses of lipoproteins were performed using supercritical fluid chromatography mass spectrometry...
January 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29337053/oral-ingestion-of-plasmalogens-can-attenuate-the-lps-induced-memory-loss-and-microglial-activation
#8
Md Shamim Hossain, Ayako Tajima, Satoshi Kotoura, Toshihiko Katafuchi
Plasmalogens (Pls) are the special phospholipids which were reported to be reduced in brain and blood samples of Alzheimer's disease (AD) patients, suggested a possibility that an oral ingestion of Pls may prevent the disease progression. Interestingly, the clinical study showed that the daily oral ingestion of Pls among the mild AD patients improved cognition. However, it is unknown of whether the oral ingestion of Pls inhibits the AD like changes in brain e.g., glial activation and accumulation of amyloid beta (Aβ) proteins...
January 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29306452/plasma-lipidome-patterns-associated-with-cardiovascular-risk-in-the-predimed-trial-a-case-cohort-study
#9
Cristina Razquin, Liming Liang, Estefanía Toledo, Clary B Clish, Miguel Ruiz-Canela, Yan Zheng, Dong D Wang, Dolores Corella, Olga Castaner, Emilio Ros, Fernando Aros, Enrique Gomez-Gracia, Miquel Fiol, José Manuel Santos-Lozano, Marta Guasch-Ferre, Lluis Serra-Majem, Aleix Sala-Vila, Pilar Buil-Cosiales, Monica Bullo, Montserrat Fito, Olga Portoles, Ramon Estruch, Jordi Salas-Salvado, Frank B Hu, Miguel A Martinez-Gonzalez
BACKGROUND: The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events. METHODS: We included 983 participants in our case-cohort study...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29282281/unbalanced-lipolysis-results-in-lipotoxicity-and-mitochondrial-damage-in-peroxisome-deficient-pex19-mutants
#10
Margret H Bülow, Christian Wingen, Deniz Senyilmaz, Dominic Gosejacob, Mariangela Sociale, Reinhard Bauer, Heike Schulze, Konrad Sandhoff, Aurelio A Teleman, Michael Hoch, Julia Sellin
Inherited Peroxisomal biogenesis disorders (PBDs) are characterized by the absence of functional peroxisomes. They are caused by mutations of peroxisomal biogenesis factors encoded by PEX genes, and result in childhood lethality. Due to the many metabolic functions fulfilled by peroxisomes, PBD pathology is complex and incompletely understood. Besides accumulation of peroxisomal educts (like very long chain fatty acids (VLCFA) or branched chain fatty acids) and lack of products (like bile acids or plasmalogens), many peroxisomal defects lead to detrimental mitochondrial abnormalities for unknown reasons...
December 27, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29217479/distinct-lipidomic-profiles-in-models-of-physiological-and-pathological-cardiac-remodeling-and-potential-therapeutic-strategies
#11
Yow Keat Tham, Kevin Huynh, Natalie A Mellett, Darren C Henstridge, Helen Kiriazis, Jenny Y Y Ooi, Aya Matsumoto, Natalie L Patterson, Junichi Sadoshima, Peter J Meikle, Julie R McMullen
Cardiac myocyte membranes contain lipids which remodel dramatically in response to heart growth and remodeling. Lipid species have both structural and functional roles. Physiological and pathological cardiac remodeling have very distinct phenotypes, and the identification of molecular differences represent avenues for therapeutic interventions. Whether the abundance of specific lipid classes is different in physiological and pathological models was largely unknown. The aim of this study was to determine whether distinct lipids are regulated in settings of physiological and pathological remodeling, and if so, whether modulation of differentially-regulated lipids could modulate heart size and function...
December 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29190918/plasma-lipid-profiling-and-diagnostic-biomarkers-for-oral-squamous-cell-carcinoma
#12
Lina Wang, Xin Wang, Ying Li, Yan Hou, Fengyu Sun, Shuang Zhou, Chunming Li, Bin Zhang
Biological requirements for tumor cell proliferation include the sustained increase of structural, energetic, signal transduction and biosynthetic precursors. Because lipids participate in membrane construction, energy storage, and cell signaling. We hypothesized that the differences in lipids between malignant carcinoma and normal controls could be reflected in the bio-fluids. A total of 100 pre-operative plasma samples were collected from 50 oral squamous cell carcinoma (OSCC), 50 normal patients and characterize by lipid profiling using ultra performance liquid chromatography/electro spray ionization mass spectrometry (UPLC-MS)...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29167411/2-chlorofatty-acids-induce-weibel-palade-body-mobilization
#13
Celine L Hartman, Mark A Duerr, Carolyn J Albert, William L Neumann, Jane McHowat, David A Ford
Endothelial dysfunction is a hallmark of multiple inflammatory diseases. Leukocyte interactions with the endothelium have significant effects on vascular wall biology and pathophysiology. Myeloperoxidase (MPO)-derived oxidant products released from leukocytes are potential mediators of inflammation and endothelial dysfunction. 2-Chlorofatty acids (2-ClFAs) are produced as a result of MPO-derived HOCl targeting plasmalogen phospholipids. Chlorinated lipids have been shown to be associated with multiple inflammatory diseases, but their impact on surrounding endothelial cells has not been examined...
November 22, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29108587/influence-of-sample-preparation-on-lipidomics-analysis-of-polar-lipids-in-adipose-tissue
#14
M A López-Bascón, M Calderón-Santiago, J Sánchez-Ceinos, A Fernández-Vega, R Guzmán-Ruiz, J López-Miranda, M M Malagon, F Priego-Capote
The main limitations of lipidomics analysis are the chemical complexity of the lipids, the range of concentrations at which they exist, and the variety of samples usually analyzed. These limitations particularly affect the characterization of polar lipids owing to the interference of neutral lipids, essentially acylglycerides, which are at high concentration and suppress ionization of low concentrated lipids in mass spectrometry detection. The influence of sample preparation on lipidomics analysis of polar lipids in adipose tissue by LC-MS/MS was the aim of this research...
January 15, 2018: Talanta
https://www.readbyqxmd.com/read/29044208/growth-factors-regulate-phospholipid-biosynthesis-in-human-fibroblast-like-synoviocytes-obtained-from-osteoarthritic-knees
#15
Katarzyna D Sluzalska, Gerhard Liebisch, Jochen Wilhelm, Bernd Ishaque, Holger Hackstein, Gerd Schmitz, Markus Rickert, Juergen Steinmeyer
Elevated levels of growth factors and phospholipids (PLs) have been found in osteoarthritic synovial fluid (SF), although the metabolic regulation of PLs is currently unknown. This study aimed to determine the effects of growth factors on the biosynthesis of PLs by fibroblast-like synoviocytes (FLS) obtained from human osteoarthritic knee joints. Electrospray ionization tandem mass spectrometry was applied to analyse the newly synthesized PLs. In the presence of stable isotope-labelled PL precursors, cultured FLS were treated with either transforming growth factor-β1 (TGF-β1), bone morphogenetic protein (BMP)-2, BMP-4, BMP-7 or insulin-like growth factor-1 (IGF-1) alone or in combination with specific inhibitors of cell signalling pathways...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040513/targeted-metabolomics-reveals-reduced-levels-of-polyunsaturated-choline-plasmalogens-and-a-smaller-dimethylarginine-arginine-ratio-in-the-follicular-fluid-of-patients-with-a-diminished-ovarian-reserve
#16
J M Chao de la Barca, T Boueilh, G Simard, L Boucret, V Ferré-L'Hotellier, L Tessier, C Gadras, P E Bouet, P Descamps, V Procaccio, P Reynier, P May-Panloup
STUDY QUESTION: Does the metabolomic profile of the follicular fluid (FF) of patients with a diminished ovarian reserve (DOR) differ from that of patients with a normal ovarian reserve (NOR)? SUMMARY ANSWER: The metabolomic signature of the FF reveals a significant decrease in polyunsaturated choline plasmalogens and methyl arginine transferase activity in DOR patients compared to NOR patients. WHAT IS KNOWN ALREADY: The composition of the FF reflects the exchanges between the oocyte and its microenvironment during its acquisition of gametic competence...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29033952/essential-role-for-ethanolamine-plasmalogen-hydrolysis-in-bacterial-lipopolysaccharide-priming-of-macrophages-for-enhanced-arachidonic-acid-release
#17
Luis Gil-de-Gómez, Alma M Astudillo, Patricia Lebrero, María A Balboa, Jesús Balsinde
Due to their high content in esterified arachidonic acid (AA), macrophages provide large amounts of eicosanoids during innate immune reactions. Bacterial lipopolysaccharide (LPS) is a poor trigger of AA mobilization in macrophages but does have the capacity to prime these cells for greatly increased AA release upon subsequent stimulation. In this work, we have studied molecular mechanisms underlying this phenomenon. By using mass spectrometry-based lipidomic analyses, we show in this work that LPS-primed zymosan-stimulated macrophages exhibit an elevated consumption of a particular phospholipid species, i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29029202/a-metabolomic-signature-of-acute-caloric-restriction
#18
Tinh-Hai Collet, Takuhiro Sonoyama, Elana Henning, Julia M Keogh, Brian Ingram, Sarah Kelway, Lining Guo, I Sadaf Farooqi
Context: The experimental paradigm of acute caloric restriction followed by refeeding can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss. Objective: Metabolomics, the measurement of hundreds of small molecule metabolites, their precursors, derivatives, and degradation products, has emerged as a useful tool for the study of physiology and disease and was used here to study the metabolic response to acute caloric restriction...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28975480/mechanism-of-phospholipid-hydrolysis-for-oyster-crassostrea-plicatula-phospholipids-during-storage-using-shotgun-lipidomics
#19
Qinsheng Chen, Xincen Wang, Peixu Cong, Yanjun Liu, Yuming Wang, Jie Xu, Changhu Xue
A fast and efficient shotgun lipidomics strategy was applied to analyze phospholipids (PL) in the oyster Crassostrea plicatula, including 29 species of phosphatidylcholine (PtdCho), 23 species of phosphatidylethanolamine (PtdEtn), 11 species of phosphatidylserine (PtdSer), 6 species of phosphatidylinositol (PtdIns), and 17 species of lysophospholipids (Lyso-PL). During storage at 4 °C for 7 days, the PL content decreased by 68.08%, but a significant increase in the FFA content was observed (from 63.11 to 318...
December 2017: Lipids
https://www.readbyqxmd.com/read/28960008/lipidomic-alterations-of-in-vitro-macrophage-infection-by-l-infantum-and-l-amazonensis
#20
Fernanda Negrão, Daniel R Abánades, Caroline F Jaeeger, Daniele F O Rocha, Katia R A Belaz, Selma Giorgio, Marcos N Eberlin, Célio F F Angolini
Particular lipid profiles have been found in two different protozoa of the Leishmania genus. Leishmania infantum, a visceral leishmaniasis causative agent and Leishmania amazonensis, a cutaneous leishmaniasis, reveal distinctive lipid contents of phosphatidylethanolamine and phosphatidylserine plasmalogens, sphingolipids, phosphatidylinositols, phosphatidylcholine, and phosphatidylethanolamine, which have been shown to be related to species, life-cycle of the parasite, and macrophage infection. L. infantum displayed a higher content of phosphatidylethanolamine plasmalogens than L...
October 24, 2017: Molecular BioSystems
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