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https://www.readbyqxmd.com/read/27888687/accurate-quantitation-of-choline-and-ethanolamine-plasmalogen-molecular-species-in-human-plasma-by-liquid-chromatography-tandem-mass-spectrometry
#1
Yurika Otoki, Shunji Kato, Fumiko Kimura, Katsutoshi Furukawa, Shinji Yamashita, Hiroyuki Arai, Teruo Miyazawa, Kiyotaka Nakagawa
Concentration of both choline plasmalogen (PC-Pls) and ethanolamine Pls (PE-Pls) in human plasma/serum has been getting attention to, since certain patients including those with neurodegenerative disorders, have been reported to exhibit reduced levels of specific Pls species. However, despite using liquid chromatography-tandem mass spectrometry (LC-MS/MS), accurate quantitation of Pls is still difficult because of less product ion from PC-Pls and quantitative issues (e.g., extraction recoveries and matrix effects)...
November 15, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27862481/correlation-of-lipidomic-composition-of-cell-lines-and-tissues-of-breast-cancer-patients-using-hydrophilic-interaction-liquid-chromatography-electrospray-ionization-mass-spectrometry-and-multivariate-data-analysis
#2
Eva Cífková, Miroslav Lísa, Roman Hrstka, David Vrána, Jiří Gatěk, Bohuslav Melichar, Michal Holčapek
RATIONALE: The goal of this work is the comparison of differences in the lipidomic compositions of human cell lines derived from normal and cancerous breast tissues, and tumor vs. normal tissues obtained after the surgery of breast cancer patients. METHODS: Hydrophilic interaction liquid chromatography - electrospray ionization mass spectrometry (HILIC/ESI-MS) method using the single internal standard approach and response factors is used for the determination of relative abundances of individual lipid species from 5 lipid classes in total lipid extracts of cell lines and tissues...
November 11, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27836780/oxidative-stress-leads-to-reduction-of-plasmalogen-serving-as-a-novel-biomarker-for-systemic-lupus-erythematosus
#3
Changfeng Hu, Jia Zhou, Shasha Yang, Haichang Li, Chunyan Wang, Xiaoling Fang, Yongsheng Fan, Jida Zhang, Xianlin Han, Chengping Wen
Oxidative stress is elevated in systemic lupus erythematosus (SLE) patients, and associated extensively with SLE pathogenesis. However, no common indicators of oxidative stress are yet in routine clinical use because of their instability, nonspecificity, and non-representation of all SLE symptoms. Moreover, the method for reproducible analysis of reactive oxygen species is still lacking. Lipids and their metabolites are essential components of biological systems, many of which serve as molecular targets of oxidative stress and play crucial roles in signaling, inflammation, and immune responses...
November 9, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27833852/molecular-cloning-heterologous-expression-and-enzymatic-characterization-of-lysoplasmalogen-specific-phospholipase-d-from-thermocrispum-sp
#4
Yusaku Matsumoto, Nana Kashiwabara, Takayuki Oyama, Kazutaka Murayama, Hideyuki Matsumoto, Shin-Ich Sakasegawa, Daisuke Sugimori
: Lysoplasmalogen (LyPls)-specific phospholipase D (LyPls-PLD) is an enzyme that catalyses the hydrolytic cleavage of the phosphoester bond of LyPls, releasing ethanolamine or choline, and 1-(1-alkenyl)-sn-glycero-3-phosphate (lysoplasmenic acid). Little is known about LyPls-PLD and metabolic pathways of plasmalogen (Pls). Reportedly, Pls levels in human serum/plasma correlate with several diseases such as Alzheimer's disease and arteriosclerosis as well as a variety of biological processes including apoptosis and cell signaling...
November 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27825781/familial-risk-for-bipolar-disorder-is-not-associated-with-impaired-peroxisomal-function-dissociation-from-docosahexaenoic-acid-deficits
#5
Robert K McNamara, Ann B Moser, Richard I Jones, Ronald Jandacek, L Rodrigo Patino, Jeffrey R Strawn, Stephen M Strakowski, Melissa P DelBelloa
Bipolar I disorder is associated with deficits in the long-chain omega-3 fatty acid docosahexaenoic acid (DHA, 22:6n-3). The final biosynthesis of DHA is mediated by peroxisomes, and some heritable peroxisomal disorders are associated with DHA deficits and progressive psychopathology. The present cross-sectional study investigated whether medication-free asymptomatic and symptomatic youth with familial risk for bipolar I disorder exhibit impaired peroxisomal function using a comprehensive diagnostic blood panel...
October 25, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27814884/corrigendum-to-plasmalogen-modulation-attenuates-atherosclerosis-in-apoe-and-apoe-gpx1-deficient-mice-atherosclerosis-243-2-2015-598-608
#6
Aliki A Rasmiena, Christopher K Barlow, Nada Stefanovic, Kevin Huynh, Ricardo Tan, Arpeeta Sharma, Dedreia Tull, Judy B de Haan, Peter J Meikle
No abstract text is available yet for this article.
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27788153/increased-%C3%AF-6-containing-phospholipids-and-primary-%C3%AF-6-oxidation-products-in-the-brain-tissue-of-rats-on-an-%C3%AF-3-deficient-diet
#7
Paul H Axelsen, Robert C Murphy, Miki Igarashi, Stanley I Rapoport
Polyunsaturated fatty acyl (PUFA) chains in both the ω3 and ω6 series are essential for normal animal brain development, and cannot be interconverted to compensate for a dietary deficiency of one or the other. Paradoxically, a dietary ω3-PUFA deficiency leads to the accumulation of docosapentaenoate (DPA, 22:5ω6), an ω6-PUFA chain that is normally scarce in the brain. We applied a high-precision LC/MS method to characterize the distribution of DPA chains across phospholipid headgroup classes, the fatty acyl chains with which they were paired, and the extent to which they were oxidatively damaged in the cortical brain of rats on an ω3-deficient diet...
2016: PloS One
https://www.readbyqxmd.com/read/27768960/anomalies-occurring-in-lipid-profiles-and-protein-distribution-in-frontal-cortex-lipid-rafts-in-dementia-with-lewy-bodies-disclose-neurochemical-traits-partially-shared-by-alzheimer-s-and-parkinson-s-diseases
#8
Raquel Marin, Noemí Fabelo, Virginia Martín, Paula Garcia-Esparcia, Isidre Ferrer, David Quinto-Alemany, Mario Díaz
Lipid rafts are highly dynamic membrane microdomains intimately associated with cell signaling. Compelling evidence has demonstrated that alterations in lipid rafts are associated with neurodegenerative diseases such Alzheimer's disease, but at present, whether alterations in lipid raft microdomains occur in other types of dementia such dementia with Lewy bodies (DLB) remains unknown. Our analyses reveal that lipid rafts from DLB exhibit aberrant lipid profiles including low levels of n-3 long-chain polyunsaturated fatty acids (mainly docosahexaenoic acid), plasmalogens and cholesterol, and reduced unsaturation and peroxidability indexes...
September 6, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27766245/statins-increase-mitochondrial-and-peroxisomal-fatty-acid-oxidation-in-the-liver-and-prevent-non-alcoholic-steatohepatitis-in-mice
#9
Han-Sol Park, Jung Eun Jang, Myoung Seok Ko, Sung Hoon Woo, Bum Joong Kim, Hyun Sik Kim, Hye Sun Park, In-Sun Park, Eun Hee Koh, Ki-Up Lee
BACKGROUND: Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation of mitochondrial fatty acid oxidation (FAO) and removal of reactive oxygen species through catalase or plasmalogen synthesis. Statins are known to prevent hepatic steatosis and non-alcoholic steatohepatitis (NASH), but underlying mechanisms of this prevention are largely unknown...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27736893/detection-of-independent-associations-of-plasma-lipidomic-parameters-with-insulin-sensitivity-indices-using-data-mining-methodology
#10
Steffi Kopprasch, Srirangan Dheban, Kai Schuhmann, Aimin Xu, Klaus-Martin Schulte, Charmaine J Simeonovic, Peter E H Schwarz, Stefan R Bornstein, Andrej Shevchenko, Juergen Graessler
OBJECTIVE: Glucolipotoxicity is a major pathophysiological mechanism in the development of insulin resistance and type 2 diabetes mellitus (T2D). We aimed to detect subtle changes in the circulating lipid profile by shotgun lipidomics analyses and to associate them with four different insulin sensitivity indices. METHODS: The cross-sectional study comprised 90 men with a broad range of insulin sensitivity including normal glucose tolerance (NGT, n = 33), impaired glucose tolerance (IGT, n = 32) and newly detected T2D (n = 25)...
2016: PloS One
https://www.readbyqxmd.com/read/27733524/human-milk-plasmalogens-are-highly-enriched-in-long-chain-pufas
#11
Sara Moukarzel, Roger A Dyer, Bernd O Keller, Rajavel Elango, Sheila M Innis
BACKGROUND: Human milk contains unique glycerophospholipids, including ethanolamine-containing plasmalogens (Pls-PEs) in the milk fat globule membrane, which have been implicated in infant brain development. Brain Pls-PEs accumulate postnatally and are enriched in long-chain polyunsaturated fatty acids (LC-PUFAs), particularly docosahexaenoic acid (DHA). Fatty acid (FA) composition of Pls-PEs in milk is poorly understood because of the analytical challenges in separating Pls-PEs from other phospholipids in the predominating presence of triacylglycerols...
November 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27701405/membrane-lipidomics-in-schizophrenia-patients-a-correlational-study-with-clinical-and-cognitive-manifestations
#12
C Tessier, K Sweers, A Frajerman, H Bergaoui, F Ferreri, C Delva, N Lapidus, A Lamaziere, J P Roiser, M De Hert, P Nuss
Schizophrenia is a severe mental condition in which several lipid abnormalities-either structural or metabolic-have been described. We tested the hypothesis that an abnormality in membrane lipid composition may contribute to aberrant dopamine signaling, and thereby symptoms and cognitive impairment, in schizophrenia (SCZ) patients. Antipsychotic-medicated and clinically stable SCZ outpatients (n=74) were compared with matched healthy subjects (HC, n=40). A lipidomic analysis was performed in red blood cell (RBC) membranes examining the major phospholipid (PL) classes and their associated fatty acids (FAs)...
October 4, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27670644/reduction-in-cardiometabolic-risk-factors-by-a-multifunctional-diet-is-mediated-via-several-branches-of-metabolism-as-evidenced-by-non-targeted-metabolite-profiling-approach
#13
Juscelino Tovar, Vanessa D de Mello, Anne Nilsson, Maria Johansson, Jussi Paananen, Marko Lehtonen, Kati Hanhineva, Inger Björck
SCOPE: MFD, a diet based on multiple functional concepts and ingredients with antiinflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic determinants related to the effects of MFD. METHODS AND RESULTS: Forty-four overweight healthy volunteers completed a randomized crossover intervention comparing MFD with a control diet devoid of the active components of MFD...
September 27, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27616591/growth-charts-for-individuals-with-rhizomelic-chondrodysplasia-punctata
#14
Angela L Duker, Tim Niiler, Grant Eldridge, Nga H Brereton, Nancy E Braverman, Michael B Bober
Rhizomelic chondrodysplasia punctata (RCDP) is a class of peroxisomal disorders characterized by defective plasmalogen biosynthesis. There are multiple recognized types of RCDP, all of which have autosomal recessive inheritance, and their associated genes are known: RCDP type 1 with PEX7, RCDP type 2 with GNPAT, RCDP type 3 with AGPS, RCDP type 4 with FAR1, and RCDP type 5 with PEX5. Among other medical/developmental issues, plasmalogen deficiency has a direct effect on bone growth and results in postnatal growth failure, the severity of which corresponds to the degree of plasmalogen deficiency...
September 12, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27581680/statin-action-enriches-hdl3-in-polyunsaturated-phospholipids-and-plasmalogens-and-reduces-ldl-derived-phospholipid-hydroperoxides-in-atherogenic-mixed-dyslipidemia
#15
Alexina Orsoni, Patrice Thérond, Ricardo Tan, Philippe Giral, Paul Robillard, Anatol Kontush, Peter J Meikle, M John Chapman
Atherogenic mixed dyslipidemia associates with oxidative stress and defective HDL antioxidative function in metabolic syndrome (MetS). The impact of statin treatment on the capacity of HDL to inactivate LDL-derived, redox-active phospholipid hydroperoxides (PCOOHs) in MetS is indeterminate. Insulin-resistant, hypertriglyceridemic, hypertensive, obese males were treated with pitavastatin (4 mg/day) for 180 days, resulting in marked reduction in plasma TGs (-41%) and LDL-cholesterol (-38%), with minor effects on HDL-cholesterol and apoAI...
November 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27575732/chemical-derivatization-and-ultrahigh-resolution-and-accurate-mass-spectrometry-strategies-for-shotgun-lipidome-analysis
#16
Eileen Ryan, Gavin E Reid
Lipids play critical structural and functional roles in the regulation of cellular homeostasis, and it is increasingly recognized that the disruption of lipid metabolism or signaling or both is associated with the onset and progression of certain metabolically linked diseases. As a result, the field of lipidomics has emerged to comprehensively identify and structurally characterize the diverse range of lipid species within a sample of interest and to quantitatively monitor their abundances under different physiological or pathological conditions...
September 20, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27535429/remodeling-of-the-postsynaptic-plasma-membrane-during-neural-development
#17
Karolina Tulodziecka, Barbara B Diaz-Rohrer, Madeline M Farley, Robin B Chan, Gilbert Di Paolo, Kandice R Levental, M Neal Waxham, Ilya Levental
Neuronal synapses are the fundamental units of neural signal transduction and must maintain exquisite signal fidelity while also accommodating the plasticity that underlies learning and development. To achieve these goals, the molecular composition and spatial organization of synaptic terminals must be tightly regulated; however, little is known about the regulation of lipid composition and organization in synaptic membranes. Here we quantify the comprehensive lipidome of rat synaptic membranes during postnatal development and observe dramatic developmental lipidomic remodeling during the first 60 postnatal days, including progressive accumulation of cholesterol, plasmalogens, and sphingolipids...
November 7, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27501728/a-novel-methodology-for-in-vivo-endoscopic-phenotyping-of-colorectal-cancer-based-on-real-time-analysis-of-the-mucosal-lipidome-a-prospective-observational-study-of-the-iknife
#18
James Alexander, Louise Gildea, Julia Balog, Abigail Speller, James McKenzie, Laura Muirhead, Alasdair Scott, Christos Kontovounisios, Shanawaz Rasheed, Julian Teare, Jonathan Hoare, Kirill Veselkov, Robert Goldin, Paris Tekkis, Ara Darzi, Jeremy Nicholson, James Kinross, Zoltan Takats
BACKGROUND: This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic adenomas. METHODS: Patients undergoing elective surgical resection for CRC were recruited at St. Mary's Hospital London and The Royal Marsden Hospital, UK. Ex vivo analysis was performed using a standard electrosurgery handpiece with aspiration of the electrosurgical aerosol to a Xevo G2-S iKnife QTof mass spectrometer (Waters Corporation)...
August 8, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27467775/changes-in-the-metabolome-in-response-to-low-dose-exposure-to-environmental-chemicals-used-in-personal-care-products-during-different-windows-of-susceptibility
#19
Sander M Houten, Jia Chen, Fiorella Belpoggi, Fabiana Manservisi, Alberto Sánchez-Guijo, Stefan A Wudy, Susan L Teitelbaum
The consequences of ubiquitous exposure to environmental chemicals remain poorly defined. Non-targeted metabolomic profiling is an emerging method to identify biomarkers of the physiological response to such exposures. We investigated the effect of three commonly used ingredients in personal care products, diethyl phthalate (DEP), methylparaben (MPB) and triclosan (TCS), on the blood metabolome of female Sprague-Dawley rats. Animals were treated with low levels of these chemicals comparable to human exposures during prepubertal and pubertal windows as well as chronically from birth to adulthood...
2016: PloS One
https://www.readbyqxmd.com/read/27389011/plasmalogen-enrichment-in-exosomes-secreted-by-a-nematode-parasite-versus-those-derived-from-its-mouse-host-implications-for-exosome-stability-and-biology
#20
Fabio Simbari, Jana McCaskill, Gillian Coakley, Marissa Millar, Rick M Maizels, Gemma Fabriás, Josefina Casas, Amy H Buck
Extracellular vesicles (EVs) mediate communication between cells and organisms across all 3 kingdoms of life. Several reports have demonstrated that EVs can transfer molecules between phylogenetically diverse species and can be used by parasites to alter the properties of the host environment. Whilst the concept of vesicle secretion and uptake is broad reaching, the molecular composition of these complexes is expected to be diverse based on the physiology and environmental niche of different organisms. Exosomes are one class of EVs originally defined based on their endocytic origin, as these derive from multivesicular bodies that then fuse with the plasma membrane releasing them into the extracellular environment...
2016: Journal of Extracellular Vesicles
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