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p53 lipid

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https://www.readbyqxmd.com/read/29442721/crosstalk-between-co-cultured-3t3-l1-and-c2c12-cells-after-the-exposure-of-nano-titanium-dioxide
#1
Vinay Kumar Tripathi, Allur Subramaniyan Sivakumar, Anupam Dhasmana, Inho Hwang
Nanotechnology is a promptly growing field in this century, and it have been extensively used in several solicitations. Reactive oxygen species (ROS) generation is one of the important mechanism of action of nanoparticles. The excess ROS generation can induce oxidative stress, so the cells are unable to sustain the normal biological redox-regulated tasks. The high oxidative stress and ROS formation condition, damage the biological macromolecules, cell signaling pathways and finally leads to cell death or cancer initiation...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29416617/low-dose-radiation-prevents-doxorubicin-induced-cardiotoxicity
#2
Xin Jiang, Yaqiong Hong, Di Zhao, Xinxin Meng, Lijing Zhao, Yanwei Du, Zan Wang, Yan Zheng, Lu Cai, Hongyu Jiang
This study aimed to develop a novel and non-invasive approach, low-dose radiation (LDR, 75 mGy X-rays), to prevent doxorubicin (DOX)-induced cardiotoxicity. BALB/c mice were randomly divided into five groups, Control, LDR (a single exposure), Sham (treated same as LDR group except for irradiation), DOX (a single intraperitoneal injection of DOX at 7.5 mg/kg), and LDR/DOX (received LDR and 72 h later received DOX). Electrocardiogram analysis displayed several kinds of abnormal ECG profiles in DOX-treated mice, but less in LDR/DOX group...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29398618/a-role-for-long-chain-acyl-coa-synthetase-4-acsl4-in-diet-induced-phospholipid-remodeling-and-obesity-associated-adipocyte-dysfunction
#3
Elizabeth A Killion, Andrew R Reeves, Mahmoud A El Azzouny, Qing-Wu Yan, Defne Surujon, John D Griffin, Thomas A Bowman, Chunyan Wang, Nirupa R Matthan, Eric L Klett, Dong Kong, John W Newman, Xianlin Han, Mi-Jeong Lee, Rosalind A Coleman, Andrew S Greenberg
OBJECTIVE: Regulation of fatty acid (FA) metabolism is central to adipocyte dysfunction during diet-induced obesity (DIO). Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown. The purpose of our studies was to determine the in vivo role of adipocyte ACSL4 in regulating obesity-associated adipocyte dysfunction. METHODS: We developed a novel mouse model with adipocyte-specific ablation of ACSL4 (Ad-KO) using loxP Cre recombinase technology...
January 31, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29383150/molecular-crosstalk-between-ferroptosis-and-apoptosis-emerging-role-of-er-stress-induced-p53-independent-puma-expression
#4
Se Hoon Hong, Dae-Hee Lee, Young-Sun Lee, Min Jee Jo, Yoon A Jeong, William T Kwon, Haroon A Choudry, David L Bartlett, Yong J Lee
Ferroptosis is a type of programmed cell death that depends on iron and is characterized by the accumulation of lipid peroxides. In the present study, we investigated the nature of the interplay between ferroptosis and other forms of cell death such as apoptosis. Human pancreatic cancer PANC-1 and BxPC-3 and human colorectal cancer HCT116 cells were treated with ferroptotic agents such as erastin and artesunate (ART) in combination with the apoptotic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29376759/estrogen-receptor-mediated-liposomal-drug-delivery-for-treating-melanoma
#5
Anirban Ganguly, Hari Krishna Reddy Rachamalla, Dwaipayan Bhattacharya, Keerti Bhamidipati, Abhishek Pal, Halley Gora Ravuri, Sumana Chakrabarti, Susanta Sekhar Adhikari, Rajkumar Banerjee
Function of steroid hormone estrogen that transactivates estrogen receptor (ER) is expressed in multiple organs. Except for malignancies of gynecological organs, ER remains largely unutilized as a target to treat cancers of ER-expressing brain, prostate, skin etc. We have previously developed estrogen targeting cationic lipid molecule (ES-C10), which showed targeted killing of ER+ breast and skin cancer cells. In this study, we explored the targeting ability of ES-C10 as a ligand as well as its additive killing effect (if any), when incorporated in two different liposomes (DCME and DCDE), carrying two anticancer molecules MCIS3 and DocetaxelTM respectively...
January 29, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29346757/p53-suppresses-metabolic-stress-induced-ferroptosis-in-cancer-cells
#6
Amy Tarangelo, Leslie Magtanong, Kathryn T Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D Attardi, Scott J Dixon
How cancer cells respond to nutrient deprivation remains poorly understood. In certain cancer cells, deprivation of cystine induces a non-apoptotic, iron-dependent form of cell death termed ferroptosis. Recent evidence suggests that ferroptosis sensitivity may be modulated by the stress-responsive transcription factor and canonical tumor suppressor protein p53. Using CRISPR/Cas9 genome editing, small-molecule probes, and high-resolution, time-lapse imaging, we find that stabilization of wild-type p53 delays the onset of ferroptosis in response to cystine deprivation...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29343087/sulfhydrated-sirtuin-1-increasing-its-deacetylation-activity-is-an-essential-epigenetics-mechanism-of-anti-atherogenesis-by-hydrogen-sulfide
#7
Congkuo Du, Xianjuan Lin, Wenjing Xu, Fengjiao Zheng, Junyan Cai, Jichun Yang, Qinghua Cui, Chaoshu Tang, Jun Cai, Guoheng Xu, Bin Geng
AIMS: Hydrogen sulfide (H2S) has a protective role in the pathogenesis of atherosclerosis by multiple pathways. Sirtuin-1 (SIRT1) is a histone deacetylase, as an essential mediated longevity gene, and has an anti-atherogenic effect by regulating the acetylation of some functional proteins. Whether SIRT1 is involved in protecting H2S in atherosclerosis and its mechanism remains unclear. RESULTS: In ApoE-knockout atherosclerosis mice, treatment with an H2S donor (NaHS or GYY4137) reduced atherosclerotic plaque area, macrophage infiltration, aortic inflammation and plasma lipid level...
January 17, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29336987/the-in-vitro-radiosensitizer-potential-of-resveratrol-on-mcf-7-breast-cancer-cells
#8
Isabel Cristina da Costa Araldi, Fernando Primitivo Romero Bordin, Francine Carla Cadoná, Fernanda Barbisan, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Tadeu Baumhardt, Ivana Beatrice Mânica da Cruz, Marta Maria Medeiros Frescura Duarte, Liliane de Freitas Bauermann
Radiation therapy is commonly applied in breast cancer (BC) patients. However, radioresistance and side effects are limiting factors of this practice. Therefore, studying substances that can enhance the radiation effect and, at the same time, protect normal cells is very relevant. Thus, the aim of this work was to assess the radiosensitizer effect of resveratrol (RV) on BC cells (MCF-7). A high cytotoxic and antiproliferative effect was observed in the treatment with 10 μM of RV + 3 Gy ionizing radiation (IR)...
January 11, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29336364/mechanism-of-chronic-stress-induced-reduced-atherosclerotic-medial-area-and-increased-plaque-instability-in-rabbit-models-of-chronic-stress
#9
Ze-Mou Yu, Xiao-Tao Deng, Ruo-Mei Qi, Lu-Yan Xiao, Chong-Qing Yang, Tao Gong
BACKGROUND: Chronic stress contributes to increased risks of atherosclerotic diseases including heart disease, stroke, and transient ischemic attack. However, its underline mechanisms are poorly understood. This study aimed to elucidate the mechanism via which chronic stress exerts its effect on atherosclerosis (AS). METHODS: Fifty male New Zealand white rabbits were used. Aortic balloon-injury model was applied. Both social stress and physical stress methods were adopted to establish chronic stress models...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29321954/a-role-for-caspase-2-in-sphingosine-kinase-1-proteolysis-in-response-to-doxorubicin-in-breast-cancer-cells-implications-for-the-chk1-suppressed-pathway
#10
Brittany L Carroll, Joseph Bonica, Achraf A Shamseddine, Yusuf A Hannun, Lina M Obeid
Sphingosine kinase 1 (SK1) is a lipid kinase whose activity produces sphingosine 1-phosphate, a prosurvival lipid associated with proliferation, angiogenesis, and invasion. SK1 overexpression has been observed in numerous cancers. Recent studies have demonstrated that SK1 proteolysis occurs downstream of the tumor suppressor p53 in response to several DNA-damaging agents. Moreover, loss of SK1 in p53-knockout mice resulted in complete protection from thymic lymphoma, providing evidence that regulation of SK1 constitutes a major tumor suppressor function of p53...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29301413/potential-anticancer-activity-of-biogenic-silver-nanoparticles-using-leaf-extract-of-rhynchosia-suaveolens-an-insight-into-the-mechanism
#11
Murali Satyanarayana Bethu, Vasudeva Reddy Netala, Latha Domdi, Vijaya Tartte, Venkateswara Rao Janapala
The present study reports a simple and eco-friendly synthesis of silver nanoparticles (AgNPs) using leaf extract of Rhynchosia suaveolens. UV-Vis analysis of R. suaveolens synthesized AgNPs (RS-AgNPs) showed surface plasmon resonance (SPR) peak at 426 nm. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis revealed that RS-AgNPs were 10-30 nm in size with spherical shape. X-ray diffraction (XRD) analysis of RS-AgNPs confirmed the crystalline nature with face-centered cubic (FCC) lattice...
January 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29290620/pharmacological-stimulation-of-p53-with-low-dose-doxorubicin-ameliorates-diet-induced-nonalcoholic-steatosis-and-steatohepatitis
#12
Begoña Porteiro, Marcos F Fondevila, Xabier Buque, Maria J Gonzalez-Rellan, Uxia Fernandez, Alfonso Mora, Daniel Beiroa, Ana Senra, Rosalia Gallego, Johan Fernø, Miguel López, Guadalupe Sabio, Carlos Dieguez, Patricia Aspichueta, Rubén Nogueiras
OBJECTIVE: Recent reports have implicated the p53 tumor suppressor in the regulation of lipid metabolism. We hypothesized that the pharmacological activation of p53 with low-dose doxorubicin, which is widely used to treat several types of cancer, may have beneficial effects on nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). METHODS: We used long-term pharmacological activation of p53 by i.p. or oral administration of low-dose doxorubicin in different animal models of NAFLD (high fat diet containing 45% and 60% kcal fat) and NASH (methionine- and choline-deficient diet and choline deficiency combined with high fat diet)...
December 15, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29288341/brain-lipid-binding-protein-mediates-the-proliferation-of-human-glioblastoma-cells-by-regulating-erk1-2-signaling-pathway-in-vitro
#13
Wei Tian, Jinhong Shi, Jianbing Qin, Guohua Jin, Xiao Han, Haoming Li
Brain lipid binding protein (BLBP) is highly expressed in the radial glial cells (RGCs) of the central nervous system (CNS), in glioblastomas, and, in vitro, in U251 cells. In this report, we have demonstrated that increased BLBP expression in glioblastoma is associated with poor survival and used a double-vector CRISPR/Cas9 lentiviral system to deplete endogenous BLBP from U251 cells, we found that loss of BLBP induced cell growth inhibition and S-phase arrest. Moreover, an increase in P53 and a decrease in p-ERK1/2 were observed after BLBP depletion, suggesting a potential mechanism by which loss of BLBP results in growth inhibition...
December 29, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29283338/aqueous-extract-of-smokeless-tobacco-gutkha-deregulates-tumor-suppressor-and-dna-repair-response-in-a-murine-model-of-smokeless-tobacco-use
#14
Angom Ranjana Devi, Mahuya Sengupta, Yashmin Choudhury
The effect of smokeless tobacco (gutkha) was investigated by treating male and female Swiss Albino mice with an aqueous extract of smokeless tobacco (AEST). AEST was administered at a dose of 25 mg kg-1 body weight per day for different time periods (6, 12, 16, and 24 weeks), and control animals were provided only drinking water without AEST for the same period. Control and AEST-treated mice were observed for different oxidative stress parameters, nitric oxide (NO) release, and myeloperoxidase (MPO) release, and they were evaluated for alterations in tumor suppressor and DNA repair responses in the liver and spleen...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29248491/atorvastatin-exerts-inhibitory-effect-on-endothelial-senescence-in-hyperlipidemic-rats-through-a-mechanism-involving-down-regulation-of-mir-21-5p-203a-3p
#15
Jie-Jie Zhang, Yin-Zhuang Zhang, Jing-Jie Peng, Nian-Sheng Li, Xiao-Ming Xiong, Qi-Lin Ma, Xiu-Ju Luo, Bin Liu, Jun Peng
Statins are reported to exert benefits on endothelial function through a mechanism involving in prevention of endothelial senescence. This study aims to explore whether atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats or ox-LDL-treated HUVECs through a mechanism involving suppress of miR-21-5p/203a-3p expression and their downstream pathway. The rats were fed with high-fat diet to establish a hyperlipidemic model, which showed an increase in plasma lipids and endothelial senescence, accompanied by the elevation in plasma levels of miR-21-5p/203a-3p, down-regulation of Drp1 and up-regulation of p53 in the aorta of hyperlipidemic rats; these phenomena were reversed by atorvastatin...
December 14, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29247772/chrysin-attenuates-testosterone-induced-benign-prostate-hyperplasia-in-rats
#16
Sherif M Shoieb, Ahmed Esmat, Amani E Khalifa, Ashraf B Abdel-Naim
Benign prostate hyperplasia (BPH) is a common age-related health problem affecting almost 3 out of 4 men in their sixties. Chrysin is a dietary phytoestrogen found naturally in bee propolis and various plant extracts. It possesses antioxidant, anti-inflammatory and anti-proliferative properties. The current study was conducted to explore the role chrysin plays in protection against testosterone-induced BPH in rats. On grounds of a preliminary experiment, a dose of chrysin (50 mg/kg) was chosen for further investigation...
December 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29229990/tumor-suppressor-p53-links-ceramide-metabolism-to-dna-damage-response-through-alkaline-ceramidase-2
#17
Ruijuan Xu, Monica Garcia-Barros, Sally Wen, Fang Li, Chih-Li Lin, Yusuf A Hannun, Lina M Obeid, Cungui Mao
p53 mediates the DNA damage response (DDR) by regulating the expression of genes implicated in cell cycle arrest, senescence, programmed cell death (PCD), and metabolism. Herein we demonstrate that human alkaline ceramidase 2 (ACER2) is a novel transcriptional target of p53 and that its transactivation by p53 mediates the DDR. We found that p53 overexpression or its activation by ionizing radiation (IR) upregulated ACER2 in cells. Two putative p53 responsive elements (p53REs) were found in its first intron of the ACER2 gene, and Chromatin Immunoprecipitation (ChIP) assays in combination with promoter activity assays demonstrated that these p53REs are the bona fide p53 binding sites that mediate ACER2 transactivation by p53...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29221940/pioglitazone-attenuates-aging-related-disorders-in-aged-apolipoprotein-e-deficient-mice
#18
Dan Shen, Hao Li, Rui Zhou, Meng-Jie Liu, Hong Yu, Dong-Fang Wu
Pioglitazone (Piog) activates peroxisome proliferator activated receptor-γ (PPARγ) and is widely used in clinic for the treatment of diabetes mellitus. PPARγ in various tissues has the essential regulatory role of multiple metabolic function, suggest that PPARγ signaling may contribute to aging processes. However, little is known about the consequences of Piog on aging in aged animal models. We used apolipoprotein E deficient (apoE-/-) mice model to evaluate the effects of Piog on aging-related disorders...
December 5, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29211796/reprogramming-pancreatic-stellate-cells-via-p53-activation-a-putative-target-for-pancreatic-cancer-therapy
#19
Maya Saison-Ridinger, Kathleen E DelGiorno, Tejia Zhang, Annabelle Kraus, Randall French, Dawn Jaquish, Crystal Tsui, Galina Erikson, Benjamin T Spike, Maxim N Shokhirev, Christopher Liddle, Ruth T Yu, Michael Downes, Ronald M Evans, Alan Saghatelian, Andrew M Lowy, Geoffrey M Wahl
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and become major contributors to fibrosis, by increasing growth factor signaling and extracellular matrix deposition. The p53 tumor suppressor is known to restrict tumor initiation and progression through cell autonomous mechanisms including apoptosis, cell cycle arrest, and senescence...
2017: PloS One
https://www.readbyqxmd.com/read/29206599/ftir-microspectroscopy-probes-particle-radiation-effect-on-hct116-cells-p53-p53
#20
Jingwen Yan, Fengqiu Zhang, Qing Huang
p53 is a crucial tumor suppressor and plays an important role in cell cycle arrest, DNA damage repair, promotion of cell senescence and apoptosis, prevention of DNA damage and maintaining genomic stability and integrity. It has been reported that p53 might also be related to radiation sensitivity, for which the involved effects and processes could be further examined biochemically at the molecular level. In this study, we explored a new spectroscopic approach to probe the radiation-induced biological effects related to p53...
December 5, 2017: Radiation Research
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