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JOURNAL ARTICLE
Ramón L Panadés-Barrueta, Denis Duflot, Juan Soto, Emilio Martínez-Núñez, Daniel Peláez
We present the detailed topographical characterisation (stationary points and minimum energy paths connecting them) of the full dimensional (81D) intermolecular potential energy surface associated with the non-covalent interactions between the NO2 radical and the pyrene (C16 H10 ) molecule. The whole procedure is (quasi) fully automated. We have used our recent algorithm vdW-TSSCDS as implemented on the freely-available AutoMekin software package. To this end, a series of inexpensive classical trajectories using forces from a low-level (semi-empirical) theory are used to sample the configuration space of the system in the search for candidates to first order saddle points...
April 25, 2024: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
#2
JOURNAL ARTICLE
Chunxia Yan, Fangyue Cheng, Jie Guan, Zhimao Li, Can Wang, Nannan Chen, Chunzu Cheng, Feijun Wang, Ziqiang Shao
The weak stiffness, huge thickness, and low specific capacitance of commonly utilized flexible supercapacitors hinder their great electrochemical performance. Learning from a biomimetic interface strategy, we design flexible film electrodes based on functional intercalated structures with excellent electrochemical properties and mechanical flexibility. A composite film with high strength and flexibility is created using graphene (reduced graphene oxide (rGO)) as the plane layer, layered double metal hydroxide (LDH) as the support layer, and cellulose nanofiber (CNF) as the connection agent and flexible agent...
April 25, 2024: ACS Applied Materials & Interfaces
#3
JOURNAL ARTICLE
Coralie Picoche, William R Young, Frédéric Barraquand
The coexistence of multiple phytoplankton species despite their reliance on similar resources is often explained with mean-field models assuming mixed populations. In reality, observations of phytoplankton indicate spatial aggregation at all scales, including at the scale of a few individuals. Local spatial aggregation can hinder competitive exclusion since individuals then interact mostly with other individuals of their own species, rather than competitors from different species. To evaluate how microscale spatial aggregation might explain phytoplankton diversity maintenance, an individual-based, multispecies representation of cells in a hydrodynamic environment is required...
April 25, 2024: Journal of Mathematical Biology
#4
JOURNAL ARTICLE
Zhiwei Gu, Kexun Wu, Jiawei Wang
UNLABELLED: The portal protein of tailed bacteriophage plays essential roles in various aspects of capsid assembly, motor assembly, genome packaging, connector formation, and infection processes. After DNA packaging is complete, additional proteins are assembled onto the portal to form the connector complex, which is crucial as it bridges the mature head and tail. In this study, we report high-resolution cryo-electron microscopy (cryo-EM) structures of the portal vertex from bacteriophage lambda in both its prohead and mature virion states...
April 25, 2024: Journal of Virology
#5
JOURNAL ARTICLE
Mariana I Tsap, Andriy S Yatsenko, Jan Hegermann, Bibiana Beckmann, Dimitros Tsikas, Halyna R Shcherbata
Mutations in Drosophila Swiss Cheese (SWS) gene or its vertebrate orthologue Neuropathy Target Esterase (NTE) lead to progressive neuronal degeneration in flies and humans. Despite its enzymatic function as a phospholipase is well-established, the molecular mechanism responsible for maintaining nervous system integrity remains unclear. In this study, we found that NTE/SWS is present in surface glia that forms the blood-brain-barrier (BBB) and that NTE/SWS is important to maintain its structure and permeability...
April 25, 2024: ELife
#6
JOURNAL ARTICLE
Riya Ghosh, Ratish R Nair, Shibaji Ghosh, Snehasish Debnath, Pabitra B Chatterjee
Histidine plays an essential role in most biological systems. Changes in the homeostasis of histidine and histidine-rich proteins are connected to several diseases. Herein, we report a water-soluble Cu(II) coordination polymer, labeled CuCP, for the fluorimetric detection of histidine and histidine-rich proteins and peptides. Single-crystal structure determination of CuCP revealed a two-dimensional wavy network structure in which a carboxylate group connects the individual Cu(II) dimer unit in a syn-anti conformation...
April 25, 2024: Inorganic Chemistry
#7
JOURNAL ARTICLE
Qianqian Gao, Guanying Xu, Guijie Wang, Wei Wang, Chao Zhu, Yang Shi, Changzhuang Guo, Jing Cong, Hongxia Ming, Dongmei Su, Xu Ma
BACKGROUND: Both the mother and the infant are negatively impacted by macrosomia. Macrosomia is three times as common in hyperglycemic mothers as in normal mothers. This study sought to determine why hyperglycemic mothers experienced higher macrosomia. Methods: Hematoxylin and Eosin staining was used to detect the placental structure of normal mother(NN), mothers who gave birth to macrosomia(NM), and mothers who gave birth to macrosomia and had hyperglycemia (DM). The gene expressions of different groups were detected by RNA-seq...
2024: Frontiers in Endocrinology
#8
JOURNAL ARTICLE
Kwame S Kutten, Jenny Trieu, Jaden Dawson, Lisa Hou, Lea Sollmann, Andrej Kral, Peter Hubka, J Tilak Ratnanather
The neocortex of the brain can be divided into six layers each with a distinct cell composition and connectivity pattern. Recently, sensory deprivation, including congenital deafness, has been shown to alter cortical structure (e.g. the cortical thickness) of the feline auditory cortex with variable and inconsistent results. Thus, understanding these complex changes will require further study of the constituent cortical layers in three-dimensional space. Further progress crucially depends on the use of objective computational techniques that can reliably characterize spatial properties of the complex cortical structure...
June 2024: MethodsX
#9
JOURNAL ARTICLE
Mariya A Yukhymenko-Lescroart, Olena Voiedilova
The aim of this study was to translate the Flourishing Scale, which is a brief 8-item measure, into Ukrainian and examine its construct validity. The Flourishing Scale has been previously validated into various languages, including Russian. While Ukrainian is a distinct language with its unique characteristics, it shares some similarities with Russian due to historical and geographical connections. These similarities encompass words with similar or related meanings, comparable sentence structures, and certain cultural references and idiomatic expressions...
June 2024: MethodsX
#10
Suvi Häkkinen, Willa I Voorhies, Ethan H Willbrand, Yi-Heng Tsai, Thomas Gagnant, Jewelia K Yao, Kevin S Weiner, Silvia A Bunge
UNLABELLED: A salient neuroanatomical feature of the human brain is its pronounced cortical folding, and there is mounting evidence that sulcal morphology is relevant to functional brain architecture and cognition. Recent studies have emphasized putative tertiary sulci (pTS): small, shallow, late-developing, and evolutionarily new sulci that have been posited to serve as functional landmarks in association cortices. A fruitful approach to characterizing brain architecture has been to delineate regions based on transitions in fMRI-based functional connectivity profiles; however, exact regional boundaries can change depending on the data used to generate the parcellation...
April 18, 2024: bioRxiv
#11
Aljoscha Nern, Frank Loesche, Shin-Ya Takemura, Laura E Burnett, Marisa Dreher, Eyal Gruntman, Judith Hoeller, Gary B Huang, Michal Januszewski, Nathan C Klapoetke, Sanna Koskela, Kit D Longden, Zhiyuan Lu, Stephan Preibisch, Wei Qiu, Edward M Rogers, Pavithraa Seenivasan, Arthur Zhao, John Bogovic, Brandon S Canino, Jody Clements, Michael Cook, Samantha Finley-May, Miriam A Flynn, Imran Hameed, Kenneth J Hayworth, Gary Patrick Hopkins, Philip M Hubbard, William T Katz, Julie Kovalyak, Shirley A Lauchie, Meghan Leonard, Alanna Lohff, Charli A Maldonado, Caroline Mooney, Nneoma Okeoma, Donald J Olbris, Christopher Ordish, Tyler Paterson, Emily M Phillips, Tobias Pietzsch, Jennifer Rivas Salinas, Patricia K Rivlin, Ashley L Scott, Louis A Scuderi, Satoko Takemura, Iris Talebi, Alexander Thomson, Eric T Trautman, Lowell Umayam, Claire Walsh, John J Walsh, C Shan Xu, Emily A Yakal, Tansy Yang, Ting Zhao, Jan Funke, Reed George, Harald F Hess, Gregory S X E Jefferis, Christopher Knecht, Wyatt Korff, Stephen M Plaza, Sandro Romani, Stephan Saalfeld, Louis K Scheffer, Stuart Berg, Gerald M Rubin, Michael B Reiser
Vision provides animals with detailed information about their surroundings, conveying diverse features such as color, form, and movement across the visual scene. Computing these parallel spatial features requires a large and diverse network of neurons, such that in animals as distant as flies and humans, visual regions comprise half the brain's volume. These visual brain regions often reveal remarkable structure-function relationships, with neurons organized along spatial maps with shapes that directly relate to their roles in visual processing...
April 18, 2024: bioRxiv
#12
Keith W Jamison, Zijin Gu, Qinxin Wang, Mert R Sabuncu, Amy Kuceyeski
Brain connectivity can be estimated in many ways, depending on modality and processing strategy. Here we present the Krakencoder, a joint connectome mapping tool that simultaneously, bidirectionally translates between structural (SC) and functional connectivity (FC), and across different atlases and processing choices via a common latent representation. These mappings demonstrate unprecedented accuracy and individual-level identifiability; the mapping between SC and FC has identifiability 42-54% higher than existing models...
April 15, 2024: bioRxiv
#13
Hanieh Falahati, Yumei Wu, Pietro De Camilli
The endoplasmic reticulum (ER) is a continuous cellular endomembrane network that displays focal specializations. Most notable examples of such specializations include the spine apparatus of neuronal dendrites, and the cisternal organelle of axonal initial segments. Both organelles exhibit stacks of smooth ER sheets with a narrow lumen and interconnected by a dense protein matrix. The actin-binding protein synaptopodin is required for their formation. Here, we report that expression in non-neuronal cells of a synaptopodin construct targeted to the ER is sufficient to generate stacked ER cisterns resembling the spine apparatus with molecular properties distinct from the surrounding ER...
April 16, 2024: bioRxiv
#14
Qi Yu, Robert J Barndt, Yawei Shen, Karim Sallam, Ying Tang, Stephen Y Chan, Joseph C Wu, Qing Liu, Haodi Wu
BACKGROUND: Phospholamban (PLN) is a key regulator of cardiac function connecting adrenergic signaling and calcium homeostasis. The R9C mutation of PLN is known to cause early onset dilated cardiomyopathy (DCM) and premature death, yet the detailed mechanisms underlie the pathologic remodeling process are not well defined in human cardiomyocytes. The aim of this study is to unravel the role of PLN R9C in DCM and identify potential therapeutic targets. METHODS: PLN R9C knock-in (KI) and patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) were generated and comprehensively examined for their expression profile, contractile function, and cellular signaling under both baseline conditions and following functional challenges...
April 17, 2024: bioRxiv
#15
JOURNAL ARTICLE
Neha Tripathi, Supriti Dutta, Bharti Yadav, Avisikta Sinha, Mangalampalli Ravikanth
Two different types of novel phenothiazine-embedded dithiasmaragdyrins containing one phenothiazine ring, two thiophene rings and two pyrrole rings connected via three meso carbons and two direct bonds in the macrocyclic framework were synthesized over the sequence of synthetic steps starting with phenothiazine. Three examples of phenothiazine-embedded dithiasmaragdyrins were synthesized by condensing appropriate phenothiazine-based pentapyrrane with pentafluorobenzaldehyde and two examples of phenothiazine sulfone embedded dithiasmaragdyrins were synthesized by condensing phenothiazine-based diol with appropriate meso-aryl dipyrromethane under mild acid-catalysed conditions...
April 24, 2024: Chemistry, An Asian Journal
#16
JOURNAL ARTICLE
Huixia He, Nannan Wei, Yi Xie, Lili Wang, Linyan Yao, Jianxi Xiao
The self-assembly of collagen within the human body creates a complex 3D fibrous network, providing structural integrity and mechanical strength to connective tissues. Recombinant collagen plays a pivotal role in the realm of biomimetic natural collagen. However, almost all of the reported recombinant collagens lack the capability of self-assembly, severely hindering their application in tissue engineering and regenerative medicine. Herein, we have for the first time constructed a series of self-assembling tyrosine-rich triple helix recombinant collagens, mimicking the structure and functionality of natural collagen...
April 24, 2024: ACS Biomaterials Science & Engineering
#17
JOURNAL ARTICLE
Elmira Mirbahaeddin, Samia Chreim
BACKGROUND: This qualitative study explores the experiences of peer support workers (PSWs) and service users (or peers) during transition from in-person to virtual mental health services. During and following the COVID-19 pandemic, the need for accessible and community-based mental health support has become increasingly important. This research aims to understand how technological factors act as bridges and boundaries to mental health peer support services. In addition, the study explores whether and how a sense of community can be built or maintained among PSWs and peers in a virtual space when connections are mediated by technology...
April 24, 2024: BMC Health Services Research
#18
JOURNAL ARTICLE
Julie R Wechsler, Susan Tamasi
BACKGROUND: When patients do not speak the same language as their doctors, they face poorer medical outcomes, decreased doctor-patient trust, and a diminished desire to seek medical care. It has been well established that interpretation is an essential part of an accessible healthcare system, but effective use of such language services relies on both the interpreters themselves and the healthcare teams working with them. This study presents an interdisciplinary examination of the motivations of undergraduate student medical interpreters, a group which serves as a bridge between these roles...
April 24, 2024: BMC Medical Education
#19
JOURNAL ARTICLE
Guido Alberto Gnecchi-Ruscone, Zsófia Rácz, Levente Samu, Tamás Szeniczey, Norbert Faragó, Corina Knipper, Ronny Friedrich, Denisa Zlámalová, Luca Traverso, Salvatore Liccardo, Sandra Wabnitz, Divyaratan Popli, Ke Wang, Rita Radzeviciute, Bence Gulyás, István Koncz, Csilla Balogh, Gabriella M Lezsák, Viktor Mácsai, Magdalena M E Bunbury, Olga Spekker, Petrus le Roux, Anna Szécsényi-Nagy, Balázs Gusztáv Mende, Heidi Colleran, Tamás Hajdu, Patrick Geary, Walter Pohl, Tivadar Vida, Johannes Krause, Zuzana Hofmanová
From AD 567-568, at the onset of the Avar period, populations from the Eurasian Steppe settled in the Carpathian Basin for approximately 250 years1 . Extensive sampling for archaeogenomics (424 individuals) and isotopes, combined with archaeological, anthropological and historical contextualization of four Avar-period cemeteries, allowed for a detailed description of the genomic structure of these communities and their kinship and social practices. We present a set of large pedigrees, reconstructed using ancient DNA, spanning nine generations and comprising around 300 individuals...
April 24, 2024: Nature
#20
REVIEW
Kwangmin Ryu, Gunhee Park, Won-Ki Cho
Eukaryotic transcription, a fundamental process that governs cell-specific gene expression, has long been the subject of extensive investigations in the fields of molecular biology, biochemistry, and structural biology. Recent advances in microscopy techniques have led to a fascinating concept known as "transcriptional condensates." These dynamic assemblies are the result of a phenomenon called liquid‒liquid phase separation, which is driven by multivalent interactions between the constituent proteins in cells...
April 25, 2024: Experimental & Molecular Medicine
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