keyword
MENU ▼
Read by QxMD icon Read
search

structural connectivity

keyword
https://www.readbyqxmd.com/read/28922636/effects-of-mutations-on-active-site-conformation-and-dynamics-of-rna-dependent-rna-polymerase-from-coxsackievirus-b3
#1
Hujun Shen, Mingsen Deng, Yachao Zhang
Recent crystal structures of RNA-dependent RNA polymerase (3D(pol)) from Coxsackievirus B3 (CVB3) revealed that a tyrosine mutation at Phe364 (F364Y) resulted in structures with open active site whereas a hydrophobic mutation at Phe364 (F364A) led to conformations with closed active site. Besides, the crystal structures showed that the F364W mutation had no preference between the open and closed active sites, similar to wild-type. In this paper, we present a molecular dynamics (MD) study on CVB3 3D(pol) in order to address some important questions raised by experiments...
September 12, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28922510/effects-of-spatial-smoothing-on-functional-brain-networks
#2
Tuomas Alakörkkö, Heini Saarimäki, Enrico Glerean, Jari Saramäki, Onerva Korhonen
Graph-theoretical methods have rapidly become a standard tool in studies of the structure and function of the human brain. Whereas the structural connectome can be fairly straightforwardly mapped onto a complex network, there are more degrees of freedom in constructing networks that represent functional connections between brain areas. For fMRI data, such networks are typically built by aggregating the BOLD signal time series of voxels into larger entities (such as Regions of Interest in some brain atlas), and determining their connection strengths from some measure of time-series correlations...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28922485/novel-3d-semiconducting-open-frameworks-based-on-cuprous-bromides-with-visible-light-driven-photocatalytic-properties
#3
Xiao-Wu Lei, Cheng-Yang Yue, Jun-Chao Wei, Rui-Qing Li, Fu-Qi Mi, Yan Li, Lu Gao, Quan-Xiu Liu
Visible light driven photocatalysts based on crystalline microporous metal halogenides received much less attention compared with dense or composite oxide semiconductors. Using the well-known photosensitive transition metal-complexes [TM(2,2-bipy)3 ](2+) (TM=Fe, Co, Ni, Ru) as templates, a special three-dimensional (3D) metal halogenide framework of [TM(2,2-bipy)3 ]Cu4 Br6 was designed with [Cu4 Br4 ] cluster as 4-connected node. These microporous materials feature narrow band gaps and stable visible light driven photocatalytic properties including water reduction to provide H2 and photodegradation of organic pollutants...
August 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28922357/analysis-of-nuclear-and-organellar-genomes-of-plasmodium-knowlesi-in-humans-reveals-ancient-population-structure-and-recent-recombination-among-host-specific-subpopulations
#4
Ernest Diez Benavente, Paola Florez de Sessions, Robert W Moon, Anthony A Holder, Michael J Blackman, Cally Roper, Christopher J Drakeley, Arnab Pain, Colin J Sutherland, Martin L Hibberd, Susana Campino, Taane G Clark
The macaque parasite Plasmodium knowlesi is a significant concern in Malaysia where cases of human infection are increasing. Parasites infecting humans originate from genetically distinct subpopulations associated with the long-tailed (Macaca fascicularis (Mf)) or pig-tailed macaques (Macaca nemestrina (Mn)). We used a new high-quality reference genome to re-evaluate previously described subpopulations among human and macaque isolates from Malaysian-Borneo and Peninsular-Malaysia. Nuclear genomes were dimorphic, as expected, but new evidence of chromosomal-segment exchanges between subpopulations was found...
September 18, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28921699/morphological-determinants-of-carrier-frequency-signal-in-katydids-orthoptera-a-comparative-analysis-using-biophysical-evidence
#5
Fernando Montealegre-Z, Jessica Ogden, Thorin Jonsson, Carl D Soulsbury
Male katydids produce mating calls by stridulation using specialized structures on the forewings. The right wing (RW) bears a scraper connected to a drum-like cell known as the mirror and a left wing (LW) that overlaps the RW and bears a serrated vein on the ventral side, the stridulatory file. Sound is generated with the scraper sweeping across the file, producing vibrations that are amplified by the mirror. Using this sound generator, katydids exploit a range of song carrier frequencies (CF) unsurpassed by any other insect group, with species singing as low as 600 Hz and others as high as 150 kHz...
September 16, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28921389/altered-structure-and-intrinsic-functional-connectivity-in-post-stroke-aphasia
#6
Mi Yang, Pu Yang, Yun-Shuang Fan, Jiao Li, Dezhong Yao, Wei Liao, Huafu Chen
Previous studies have demonstrated that alterations of gray matter exist in post-stroke aphasia (PSA) patients. However, so far, few studies combined structural alterations of gray matter volume (GMV) and intrinsic functional connectivity (iFC) imbalances of resting-state functional MRI to investigate the mechanism underlying PSA. The present study investigated specific regions with GMV abnormality in patients with PSA (n = 17) and age- and sex- matched healthy controls (HCs, n = 20) using voxel-based morphometry...
September 18, 2017: Brain Topography
https://www.readbyqxmd.com/read/28921258/models-of-kleptoparasitism-on-networks-the-effect-of-population-structure-on-food-stealing-behaviour
#7
Christoforos Hadjichrysanthou, Mark Broom, Jan Rychtář
The behaviour of populations consisting of animals that interact with each other for their survival and reproduction is usually investigated assuming homogeneity amongst the animals. However, real populations are non-homogeneous. We focus on an established model of kleptoparasitism and investigate whether and how much population heterogeneities can affect the behaviour of kleptoparasitic populations. We consider a situation where animals can either discover food items by themselves or attempt to steal the food already discovered by other animals through aggressive interactions...
September 18, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28919944/network-analysis-on-attitudes-a-brief-tutorial
#8
Jonas Dalege, Denny Borsboom, Frenk van Harreveld, Han L J van der Maas
In this article, we provide a brief tutorial on the estimation, analysis, and simulation on attitude networks using the programming language R. We first discuss what a network is and subsequently show how one can estimate a regularized network on typical attitude data. For this, we use open-access data on the attitudes toward Barack Obama during the 2012 American presidential election. Second, we show how one can calculate standard network measures such as community structure, centrality, and connectivity on this estimated attitude network...
July 2017: Social Psychological and Personality Science
https://www.readbyqxmd.com/read/28919535/altered-gray-matter-volume-cerebral-blood-flow-and-functional-connectivity-in-chronic-stroke-patients
#9
Peifang Miao, Caihong Wang, Peng Li, Sen Wei, Chunshan Deng, Dandan Zheng, Jingliang Cheng
It is entangled connections and intensive functional interactions between cortex and subcortical structures that enable our brain to perform delicate movement, and poses plasticity to recover from stroke. However, it is still unclear how cortical structures and functions change in well-recovered patients from subcortical infarctions in motor pathway. In order to reveal neuroplasticity underlying well-recovered stroke patients, both structural (gray matter volume, GMV) and functional reorganizations (cerebral blood flow, CBF and resting-state functional connectivity, rsFC) were investigated by using multi-modal MRI...
September 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28919511/viscoelastic-properties-of-%C3%AE-keratin-fibers-in-hair
#10
Yang Yu, Wen Yang, Marc André Meyers
Considerable viscoelasticity and strain-rate sensitivity are a characteristic in α-keratin fibers, which can be considered a biopolymer. The understanding of viscoelasticity is an important part to the knowledge of the overall mechanical properties of these biological materials. Here, horse and human hairs are examined to analyze the sources of this response. The dynamic mechanical response of α-keratin fibers over a range of frequencies and temperatures is analyzed using a dynamic mechanical analyzer. The α-keratin fibers behave more elastically at higher frequencies while they become more viscous at higher temperatures...
September 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28918707/wdnfinder-a-method-for-minimum-driver-node-set-detection-and-analysis-in-directed-and-weighted-biological-network
#11
Chu Yanshuo, Wang Zhenxing, Wang Rongjie, Zhang Ningyi, Li Jie, Hu Yang, Teng Mingxiang, Wang Yadong
Structural controllability is the generalization of traditional controllability for dynamical systems. During the last decade, interesting biological discoveries have been inferred by applied structural controllability analysis to biological networks. However, false positive/negative information (i.e. nodes and edges) widely exists in biological networks that documented in public data sources, which can hinder accurate analysis of structural controllability. In this study, we propose WDNfinder, a comprehensive analysis package that provides structural controllability with consideration of node connection strength in biological networks...
September 4, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28918320/in-silico-interaction-analysis-of-cannabinoid-receptor-interacting-protein-1b-crip1b-cb1-cannabinoid-receptor
#12
Pratishtha Singh, Anjali Ganjiwale, Allyn C Howlett, Sudha M Cowsik
Cannabinoid Receptor Interacting Protein isoform 1b (CRIP1b) is known to interact with the CB1 receptor. Alternative splicing of the CNRIP1 gene produces CRIP1a and CRIP1b with a difference in the third exon only. Exons 1 and 2 encode for a functional domain in both proteins. CRIP1a is involved in regulating CB1 receptor internalization, but the function of CRIP1b is not very well characterized. Since there are significant identities in functional domains of these proteins, CRIP1b is a potential target for drug discovery...
September 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28918301/mathematical-fundamentals-for-the-noise-immunity-of-the-genetic-code
#13
Elena Fimmel, Lutz Strüngmann
Symmetry is one of the essential and most visible patterns that can be seen in nature. Starting from the left-right symmetry of the human body, all types of symmetry can be found in crystals, plants, animals and nature as a whole. Similarly, principals of symmetry are also some of the fundamental and most useful tools in modern mathematical natural science that play a major role in theory and applications. As a consequence, it is not surprising that the desire to understand the origin of life, based on the genetic code, forces us to involve symmetry as a mathematical concept...
September 13, 2017: Bio Systems
https://www.readbyqxmd.com/read/28918262/circuit-changes-in-motor-cortex-during-motor-skill-learning
#14
Andrew E Papale, Bryan M Hooks
Motor cortex is important for motor skill learning, particularly the dexterous skills necessary for our favorite sports and careers. We are especially interested in understanding how plasticity in motor cortex contributes to skill learning. Although human studies have been helpful in understanding the importance of motor cortex in learning skilled tasks, animal models are necessary for achieving a detailed understanding of the circuitry underlying these behaviors and the changes that occur during training. We review data from these models to try to identify sites of plasticity in motor cortex, focusing on rodents as a model system...
September 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28918259/disrupted-structural-and-functional-connectivity-networks-in-ischemic-stroke-patients
#15
Jingna Zhang, Ye Zhang, Li Wang, Linqiong Sang, Jun Yang, Rubing Yan, Pengyue Li, Jian Wang, Mingguo Qiu
Local lesions caused by stroke may result in extensive structural and functional reorganization in the brain. Previous studies of this phenomenon have focused on specific brain networks. Here, we aimed to discover abnormalities in whole-brain networks and to explore the decoupling between structural and functional connectivity in patients with stroke. Fifteen ischemic stroke patients and 23 normal controls (NCs) were recruited in this study. A graph theoretical analysis was employed to investigate the abnormal topological properties of structural and functional brain networks in patients with stroke...
September 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28917914/structure-enzymatic-transformation-anticancer-activity-of-fucoidan-and-sulphated-fucooligosaccharides-from-sargassum-horneri
#16
Artem S Silchenko, Anton B Rasin, Mikhail I Kusaykin, Anatoly I Kalinovsky, Zhang Miansong, Liu Changheng, Olesya Malyarenko, Anastasiya O Zueva, Tatyana N Zvyagintseva, Svetlana P Ermakova
Structure and anticancer activity of fucoidan from Sargassum horneri and from products of its enzymatic transformation were investigated. A gene that encodes fucoidanase ffa1 in the marine bacteria F. algae was identified, cloned and the protein (FFA1) was produced in Escherichia coli. The mass of the gene product FFA1 is 111kDa. Sequence analysis has revealed that fucoidanase FFA1 belongs to the GH107 (CAZy) family. Recombinant fucoidanase FFA1 was used to produce fucooligosaccharides. Structure of 5 sulphated oligosaccharides with polymerization degree 4-10 was established by NMR-spectroscopy...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917813/structural-impacts-on-the-timing-and-amplitude-of-the-negative-bold-response
#17
David Provencher, Alexandre Bizeau, Guillaume Gilbert, Yves Bérubé-Lauzière, Kevin Whittingstall
The positive (PBR) and negative BOLD responses (NBR) arising in task-fMRI display varying magnitudes and dynamics across voxels. While the effects of structure, particularly of veins, on the PBR have been studied, little is known of NBR-structure relationships. Like the PBR, the NBR is often used as a surrogate marker of neuronal activation in both basic and clinical research and assessing its relationship with cortical structure may help interpret group differences. We therefore investigated how local structure affects BOLD amplitude and timing in PBR and NBR areas using multi-band fMRI during visual stimulation to obtain high temporal resolution (TR=0...
September 13, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28917698/introducing-axonal-myelination-in-connectomics-a-preliminary-analysis-of-g-ratio-distribution-in-healthy-subjects
#18
REVIEW
Matteo Mancini, Giovanni Giulietti, Nicholas Dowell, Barbara Spanò, Neil Harrison, Marco Bozzali, Mara Cercignani
Microstructural imaging and connectomics are two research areas that hold great potential for investigating brain structure and function. Combining these two approaches can lead to a better and more complete characterization of the brain as a network. The aim of this work is characterizing the connectome from a novel perspective using the myelination measure given by the g-ratio. The g-ratio is the ratio of the inner to the outer diameters of a myelinated axon, whose aggregated value can now be estimated in vivo using MRI...
September 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28917688/a-randomized-trial-of-pocket-echocardiography-integrated-mobile-health-device-assessments-in-modern-structural-heart-disease-clinics
#19
Sanjeev P Bhavnani, Srikanth Sola, David Adams, Ashwin Venkateshvaran, P K Dash, Partho P Sengupta
OBJECTIVES: This study sought to determine whether mobile health (mHealth) device assessments used as clinical decision support tools at the point-of-care can reduce the time to treatment and improve long-term outcomes among patients with rheumatic and structural heart diseases (SHD). BACKGROUND: Newly developed smartphone-connected mHealth devices represent promising methods to diagnose common diseases in resource-limited areas; however, the impact of technology-based care on long-term outcomes has not been rigorously evaluated...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28917641/changes-in-innervation-of-lumbar-motoneurons-and-organization-of-premotor-network-following-training-of-transected-adult-rats
#20
Loubna Khalki, Karina Sadlaoud, Julie Lerond, Jacques-Olivier Coq, Jean-Michel Brezun, Laurent Vinay, Patrice Coulon, Hélène Bras
Rats with complete spinal cord transection (SCT) can recover hindlimb locomotor function under strategies combining exercise training and 5-HT agonist treatment. This recovery is expected to result from structural and functional re-organization within the spinal cord below the lesion. To begin to understand the nature of this reorganization, we examined synaptic changes to identified gastrocnemius (GS) or tibialis anterior (TA) motoneurons (MNs) in SCT rats after a schedule of early exercise training and delayed 5-HT agonist treatment...
September 13, 2017: Experimental Neurology
keyword
keyword
89084
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"