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https://www.readbyqxmd.com/read/28239694/improved-stability-of-a-metallic-state-in-benzothienobenzothiophene-based-molecular-conductors-an-effective-increase-of-dimensionality-with-hydrogen-bonds
#1
Toshiki Higashino, Akira Ueda, Junya Yoshida, Hatsumi Mori
A dihydroxy-substituted benzothienobenzothiophene, BTBT(OH)2, was synthesized, and its charge-transfer (CT) salt, β-[BTBT(OH)2]2ClO4, was successfully obtained. Thanks to the introduced hydroxy groups, a hydrogen-bonded chain structure connecting the BTBT molecules and counter anions was formed in the CT salt, which effectively increases the dimensionality of the electronic structure and consequently leads to a stable metallic state.
February 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28239637/alzheimer-s-disease-the-influence-of-age-on-clinical-heterogeneity-through-the-human-brain-connectome
#2
Bradford C Dickerson, Michael Brickhouse, Scott McGinnis, David A Wolk
INTRODUCTION: One major factor that influences the heterogeneity of Alzheimer's disease (AD) is age: younger AD patients more frequently exhibit atypical forms of AD. We propose that this age-related heterogeneity can be understood better by considering age-related differences in atrophy in the context of large-scale brain networks subserving cognitive functions that contribute to memory. METHODS: We examined data from 75 patients with mild AD dementia from Alzheimer's Disease Neuroimaging Initiative...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28239517/cortical-interactions-during-the-resolution-of-information-processing-demands-in-autism-spectrum-disorders
#3
Kristina Denisova, Guihu Zhao, Zhishun Wang, Suzanne Goh, Yuankai Huo, Bradley S Peterson
INTRODUCTION: Our flexible and adaptive interactions with the environment are guided by our individual representation of the physical world, estimated through sensation and evaluation of available information against prior knowledge. When linking sensory evidence with higher-level expectations for action, the central nervous system (CNS) in typically developing (TD) individuals relies in part on distributed and interacting cortical regions to communicate neuronal signals flexibly across the brain...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28239206/ruling-out-static-latent-homophily-in-citation-networks
#4
Peter Wittek, Sándor Darányi, Gustaf Nelhans
Citation and coauthor networks offer an insight into the dynamics of scientific progress. We can also view them as representations of a causal structure, a logical process captured in a graph. From a causal perspective, we can ask questions such as whether authors form groups primarily due to their prior shared interest, or if their favourite topics are 'contagious' and spread through co-authorship. Such networks have been widely studied by the artificial intelligence community, and recently a connection has been made to nonlocal correlations produced by entangled particles in quantum physics-the impact of latent hidden variables can be analyzed by the same algebraic geometric methodology that relies on a sequence of semidefinite programming (SDP) relaxations...
2017: Scientometrics
https://www.readbyqxmd.com/read/28238871/utility-of-the-lone-star%C3%A2-retractor-system-in-microsurgical-carotid-endarterectomy-technical-notes
#5
Shingo Toyota, Tetsuya Kumagai, Tetsu Goto, Kanji Mori, Takuyu Taki
BACKGROUND: The retractor system is an important device in carotid endarterectomy (CEA). We applied the Lone Star® (LS) retractor system, which is a self-retaining retractor originally designed for improved visualization in many other surgical fields, in microsurgical CEA. METHODS: The LS disposal retractor (14.1 cm x 14.1 cm) and LS elastic stays (5mm sharp hook) were utilized as a retractor system in 38 consecutive CEAs. RESULTS: Using the LS retractor system, a shallow operative field could be obtained by lifting up the connective tissue surrounding the deep structures hooked by the LS elastic stays...
February 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28238785/zn-2-dependent-autocatalytic-activity-of-the-bordetella-pertussis-cyaa-hemolysin
#6
Veerada Raksanoh, Lalida Shank, Panchika Prangkio, Mattayaus Yentongchai, Somsri Sakdee, Chompounoot Imtong, Chanan Angsuthanasombat
Proteolytic degradation of the ∼100-kDa isolated RTX (Repeat-in-ToXin) subdomain (CyaA-RTX) of the Bordetella pertussis CyaA-hemolysin (CyaA-Hly) was evidently detected upon solely-prolonged incubation. Here, a truncated CyaA-Hly fragment (CyaA-HP/BI) containing hydrophobic and acylation regions connected with the first RTX block (BI1015-1088) was constructed as a putative precursor for investigating its potential autocatalysis. The 70-kDa His-tagged CyaA-HP/BI fragment which was over-expressed in Escherichia coli as insoluble aggregate was entirely solubilized with 4 M urea...
February 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28238532/human-%C3%AE-b2-crystallin-forms-a-face-en-face-dimer-in-solution-an-integrated-nmr-and-saxs-study
#7
Zhaoyong Xi, Matthew J Whitley, Angela M Gronenborn
βγ-Crystallins are long-lived eye lens proteins that are crucial for lens transparency and refractive power. Each βγ-crystallin comprises two homologous domains, which are connected by a short linker. γ-Crystallins are monomeric, while β-crystallins crystallize as dimers and multimers. In the crystal, human βB2-crystallin is a domain-swapped dimer while the N-terminally truncated βB1-crystallin forms a face-en-face dimer. Combining and integrating data from multi-angle light scattering, nuclear magnetic resonance, and small-angle X-ray scattering of full-length and terminally truncated human βB2-crystallin in solution, we show that both these βB2-crystallin proteins are dimeric, possess C2 symmetry, and are more compact than domain-swapped dimers...
February 16, 2017: Structure
https://www.readbyqxmd.com/read/28238141/nanoscript-a-versatile-nanoparticle-based-synthetic-transcription-factor-for-innovative-gene-manipulation
#8
Kholud Dardir, Christopher Rathnam, KiBum Lee
Cellular reprogramming and stem cell-based therapies have shown tremendous potential in the field of regenerative medicine. To that end, developing tools to control stem cell fate is an attractive area of research for replacing damaged and diseased cells and reestablishing functional connections for tissue repair. Transcription factor (TFs) proteins are well known to regulate gene expression and direct stem cell fate. Inspired by natural TFs, NanoScript, a nanoparticle (NP)-based platform, mimics TFs to afford control over gene expression and stem cell fate for regenerative medicine...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28238006/the-development-of-a-novel-bone-filler-titanium-wire-ball
#9
Ichiro Tsukamoto, Masao Akagi
In designing bone fillers, hardness has heretofore not been a major concern. Fillers are typically very hard and thus often accelerate the collapse of the adjacent bones. We developed a novel, relatively soft bone filler, whose hardness is similar to the human cancellous bone. The structure is simple: a 0.14-mm-diameter pure titanium wire was rolled and folded with both ends buried in the central portion, resulting in a ball of 4-mm diameter with 83% internal void ratio, having 300-500 μm internal gaps. The balls are chemically washed in an acidic solution at the end of the manufacturing process...
February 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28237606/a-symptom-network-structure-of-the-psychosis-spectrum
#10
Geeske van Rooijen, Adela-Maria Isvoranu, Carin J Meijer, Claudia D van Borkulo, Henricus G Ruhé, Lieuwe de Haan
Current diagnostic systems mainly focus on symptoms needed to classify patients with a specific mental disorder and do not take into account the variation in co-occurring symptoms and the interaction between the symptoms themselves. The innovative network approach aims to further our understanding of mental disorders by focusing on meaningful connections between individual symptoms of a disorder and has thus far proven valuable insights to psychopathology. The aims of current study were to I) construct a symptom network and investigate interactions between a wide array of psychotic symptoms; II) identify the most important symptoms within this network and III) perform an explorative shortest pathway analysis between depressive and delusional symptoms...
February 22, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28237226/unraveling-the-contact-patterns-and-network-structure-of-pig-shipments-in-the-united-states-and-its-association-with-porcine-reproductive-and-respiratory-syndrome-virus-prrsv-outbreaks
#11
Kyuyoung Lee, Dale Polson, Erin Lowe, Rodger Main, Derald Holtkamp, Beatriz Martínez-López
The analysis of the pork value chain is becoming key to understanding the risk of infectious disease dissemination in the swine industry. In this study, we used social network analysis to characterize the swine shipment network structure and properties in a typical multisite swine production system in the US. We also aimed to evaluate the association between network properties and porcine respiratory and reproductive syndrome virus (PRRSV) transmission between production sites. We analyzed the 109,868 swine shipments transporting over 93 million swine between more than 500 production sites from 2012 to 2014...
March 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28236745/topological-and-quantum-molecular-descriptors-as-effective-tools-for-analyzing-cytotoxic-activity-achieved-by-a-series-of-diselanediyldibenzene-4-1-diylnide-biscarbamate-derivatives
#12
María Font, Daniel Plano, Carmen Sanmartín, Juan Antonio Palop
A molecular modeling study has been carried out on a previously reported series of (diselanediyldibenzene-4,1-diylnide)biscarbamate derivatives that show cytotoxic and antiproliferative in vitro activity against MCF-7 human cell line; radical scavenging properties were also confirmed when these compounds were tested for their ability to scavenge DPPH and ABTS radicals. The data obtained allowed us to classify the compounds into two different groups: (a) aliphatic carbamates for which the activity could be related with a first nucleophilic attack (mediated by H2O, for example) on the selenium atoms of the central scaffold, followed by the release of the alkyl N-(4-selanylphenyl) and N-(4-selenenophenyl)carbamate moieties...
February 9, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28236102/altered-bone-mechanics-architecture-and-composition-in-the-skeleton-of-timp-3-deficient-mice
#13
Brendyn Miller, Lyudmila Spevak, Lyudmila Lukashova, Behzad Javaheri, Andrew A Pitsillides, Adele Boskey, George Bou-Gharios, Alessandra Carriero
Tissue inhibitor of metalloproteinases-3 (TIMP-3) maintains a healthy extracellular matrix by regulating matrix metalloproteinases (MMP), disintegrin-metalloproteinases (ADAM), and disintegrin-metalloproteinases with ThromboSpondin-like motifs (ADAMTS) activity. Currently, there is a need for a comprehensive understanding of the effects of TIMP-3 on the bone quality and integrity. In this study, we examined the mechanical, morphological, and compositional properties of TIMP-3 knock out (Timp-3 (-/-)) mouse bone...
February 24, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28236049/analysis-of-the-venous-channel-within-the-clivus-using-multidetector-computed-tomography-digital-subtraction-venography
#14
Katsuhiro Mizutani, Masahiro Toda, Jun Kurasawa, Takenori Akiyama, Hirokazu Fujiwara, Masahiro Jinzaki, Kazunari Yoshida
PURPOSE: Although neuroradiologists and skull base neurosurgeons are aware of the existence of veins within the clivus, such vessels have seldom been described in the literature. The aim of the present study is to elucidate the detailed venous structure of the clivus. METHODS: Computed tomography digital subtraction venography (CT-DSV) images of 50 unruptured aneurysm cases were examined retrospectively. RESULTS: Eighteen emissary veins were identified in 14 (28...
February 24, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28235896/pathogenic-huntington-alters-bmp-signaling-and-synaptic-growth-through-local-disruptions-of-endosomal-compartments
#15
Yulia Akbergenova, J Troy Littleton
Huntington's disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) stretch within the Huntingtin (Htt) protein. Pathogenic Htt disrupts multiple neuronal processes, including gene expression, axonal trafficking, proteasome and mitochondrial activity, and intracellular vesicle trafficking. However, the primary pathogenic mechanism and subcellular site of action for mutant Htt are still unclear. Using a Drosophila HD model, we found that pathogenic Htt expression leads to a profound overgrowth of synaptic connections that directly correlates with the levels of Htt at nerve terminals...
February 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28235785/emergence-of-communities-and-diversity-in-social-networks
#16
Xiao Han, Shinan Cao, Zhesi Shen, Boyu Zhang, Wen-Xu Wang, Ross Cressman, H Eugene Stanley
Communities are common in complex networks and play a significant role in the functioning of social, biological, economic, and technological systems. Despite widespread interest in detecting community structures in complex networks and exploring the effect of communities on collective dynamics, a deep understanding of the emergence and prevalence of communities in social networks is still lacking. Addressing this fundamental problem is of paramount importance in understanding, predicting, and controlling a variety of collective behaviors in society...
February 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28235406/network-topology-of-nav1-7-mutations-in-sodium-channel-related-painful-disorders
#17
Dimos Kapetis, Jenny Sassone, Yang Yang, Barbara Galbardi, Markos N Xenakis, Ronald L Westra, Radek Szklarczyk, Patrick Lindsey, Catharina G Faber, Monique Gerrits, Ingemar S J Merkies, Sulayman D Dib-Hajj, Massimo Mantegazza, Stephen G Waxman, Giuseppe Lauria
BACKGROUND: Gain-of-function mutations in SCN9A gene that encodes the voltage-gated sodium channel NaV1.7 have been associated with a wide spectrum of painful syndromes in humans including inherited erythromelalgia, paroxysmal extreme pain disorder and small fibre neuropathy. These mutations change the biophysical properties of NaV1.7 channels leading to hyperexcitability of dorsal root ganglion nociceptors and pain symptoms. There is a need for better understanding of how gain-of-function mutations alter the atomic structure of Nav1...
February 24, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28231568/fiber-connections-of-the-caudal-corpus-cerebelli-with-special-reference-to-the-intrinsic-circuitry-in-a-teleost-oreochromis-niloticus
#18
Kosuke Imura, Naoyuki Yamamoto, Masami Yoshimoto, Masato Endo, Kengo Funakoshi, Hironobu Ito
The caudal part of the corpus cerebelli of Nile tilapia can be divided into dorsal and ventral regions. The granule cell layer of the dorsal (dGL) and ventral (vGL) regions of the caudal corpus cerebelli is known to receive indirect inputs from the telencephalon relayed by the nucleus paracommissuralis. The descending pathways are topographically organized, and the dGL and vGL receive inputs from different dorsal telencephalic parts. The caudal corpus cerebelli, in turn, projects extracerebellar efferents. However, it remains unknown how the descending telencephalic inputs are processed within the cerebellum...
February 24, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28230388/familial-ethnic-socialization-gender-role-attitudes-and-ethnic-identity-development-in-mexican-origin-early-adolescents
#19
Delida Sanchez, Tiffany A Whittaker, Emma Hamilton, Sarah Arango
OBJECTIVES: This study examined the relations between familial ethnic socialization and ethnic identity development in 438 Mexican-origin (n = 242 boys and n = 196 girls) preadolescents. In addition, machismo and marianismo gender role attitudes were examined as potential mediators in this link. METHOD: Confirmatory factor analyses (CFA) of the Familial Ethnic Socialization Scale (FES), Machismo Measure (MM), Marianismo Beliefs Scale (MBS), and the Ethnic Identity Brief Scale (EISB) were conducted to test the factor structure with a preadolescent Mexican-origin sample...
February 23, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28229152/an-anionic-metal-organic-framework-with-ternary-building-units-for-rapid-and-selective-adsorption-of-dyes
#20
Shuo Yao, Tong Xu, Nian Zhao, Lirong Zhang, Qisheng Huo, Yunling Liu
A novel metal-organic framework, [(CH3)2NH2]2[Cu3O(SO4)3Cu2L2(DMF)(H2O)]·9DMF (JLU-Liu39) H2L = pyridine-3,5-bis(phenyl-4-carboxylic acid), has been successfully synthesized under solvothermal conditions. Structure analysis indicates that the framework of JLU-Liu39 is constructed by ternary building units which include a rare hexa-nuclear [Cu6O2(SO4)6] cluster, a classical [Cu2(CO2)4] paddlewheel, and a 3-connected hetero-N, O donor ligand. The whole 3D framework possesses a (3,4,4)-connected fjh topology and a large window size of 25...
February 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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