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https://www.readbyqxmd.com/read/29036882/biomineralization-of-fucoidan-peptide-blends-and-their-potential-applications-in-bone-tissue-regeneration
#1
Harrison T Pajovich, Ipsita A Banerjee
Fucoidan (Fuc), a natural polysaccharide derived from brown seaweed algae, and gelatin (Gel) were conjugated to form a template for preparation of biomimetic scaffolds for potential applications in bone tissue regeneration. To the Fuc-Gel we then incorporated the peptide sequence MTNYDEAAMAIASLN (MTN) derived from the E-F hand domain, known for its calcium binding properties. To mimic the components of the extracellular matrix of bone tissue, the Fuc-Gel-MTN assemblies were incubated in simulated body fluid (SBF) to induce biomineralization, resulting in the formation of β-tricalcium phosphate, and hydroxyapatite (HAp)...
September 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29034940/near-infrared-light-and-ph-responsive-au-carbon-calcium-phosphate-nanoparticles-for-imaging-and-chemo-photothermal-cancer-therapy-of-cancer-cells
#2
Huiyuan Wang, Manjie Zhang, Lingyu Zhang, Shengnan Li, Lu Li, Xiliang Li, Min Yu, Zhongcheng Mou, Tingting Wang, Chungang Wang, Zhongmin Su
A simple, mild and reproducible synthetic route was developed to fabricate the multifunctional Au@carbon/calcium phosphate core-shell nanoparticles (Au@C/CaP NPs), which act as an efficient nanoplatform for pH/near-infrared (NIR) dual-responsive drug delivery, X-ray computed tomography (CT) imaging and synergistic chemo-photothermal cancer therapy in vitro.
October 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29034196/protective-effect-of-ethyl-acetate-fraction-of-biophytum-sensitivum-extract-against-sodium-oxalate-induced-urolithiasis-in-rats
#3
Anil T Pawar, Niraj S Vyawahare
The methanolic whole plant extract of Biophytum sensitivum (gǎnyìng cǎo) has been found to possess antiurolithiatic effect. The present study was undertaken to evaluate the antiurolithiatic effect of some fractions of methanolic whole plant extract of B. sensitivum (MBS) in rats as a step toward activity-directed isolation of antiurolithiatic component. The MBS was successively extracted with dichloromethane, ethyl acetate, ethanol and water to obtain fractions. Sodium oxalate (70 mg/kg, i.p.) was administered to rats for seven days to develop calcium oxalate urolithiasis...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033852/activation-of-casein-kinase-ii-by-gallic-acid-induces-bik-bax-bak-mediated-er-ca-ros-dependent-apoptosis-of-human-oral-cancer-cells
#4
Meng-Liang Lin, Shih-Shun Chen
Induction of the generation of endoplasmic reticulum (ER) calcium (Ca(++))-mediated reactive oxygen species (ROS) by gallic acid (GA) has been implicated in the mitochondrial apoptotic death of human oral cancer (OC) cells, but the molecular mechanism by which GA causes ER Ca(++) release of OC cells to undergo cell death remains unclear. Here, we report that GA-induced phosphorylation of B-cell lymphoma 2 (BCL-2)-interacting killer (BIK) (threonine (Thr) 33/Serine (Ser) 35) and p53 (Ser 15 and Ser 392), Bcl-2-associated x protein (BAX)/BCL-2 antagonist killer 1 (BAK) oligomerization on the ER and mitochondria, rising of cytosolic Ca(+)(+) and ROS, cytochrome c (Cyt c) release from the mitochondria, Ψm loss, and apoptosis were suppressed in cells co-treated with a specific inhibitor of casein kinase II (CK II) (4,5,6,7-tetrabromobenzotriazole)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29031993/the-gdf5-mutant-bb-1-enhances-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#5
Francesca Gunnella, Elke Kunisch, Stefan Maenz, Victoria Horbert, Long Xin, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann, Matthias Bungartz
BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic proteins (BMPs; e.g., GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and support complete bone regeneration. The biologically optimized GDF5 mutant BB-1 may represent an attractive drug candidate for this purpose. PURPOSE: The aim of the current study was to test an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing low-dose BB-1 in a sheep lumbar osteopenia model...
October 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29029848/fluoride-containing-bioactive-glass-composite-for-orthodontic-adhesives-ion-release-properties
#6
N A Al-Eesa, F S L Wong, A Johal, R G Hill
OBJECTIVE: Dental materials that release calcium, phosphate and fluoride ions could prevent demineralisation and/or enhance remineralisation of enamel. The objective was to develop a novel bioactive glass (BAG) resin and investigate pH changes and ion release in 3 immersion media. METHODS: Quench melt derived BAG (35.25% SiO2, 6% Na2O, 43% CaO, 5.75% P2O5, and 10% CaF2) was incorporated into a resin (42.25% BisEMA, 55% TEGDMA, 0.25% DMAEM, 0.5% camphorquinone and 2% 4-Meta), with a filler load of 80% by weight...
October 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29029193/sex-and-iron-modify-fibroblast-growth-factor-23-fgf23-concentration-in-1-year-old-children
#7
Elisa Holmlund-Suila, Maria Enlund-Cerullo, Saara Valkama, Helena Hauta-Alus, Jenni Rosendahl, Otto Helve, Timo Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie
Context: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis but its regulation is inadequately characterized. Objective: To examine regulators of FGF23, especially sex and iron status, in early childhood. Design: A cross-sectional study involving 1-year-old children. Setting and participants: Healthy term infants with a birth weight appropriate for gestational age were recruited to an ongoing vitamin D trial at the Kätilöopisto Maternity Hospital, Helsinki, Finland...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028848/the-stability-of-augmented-bone-between-two-different-membranes-used-for-guided-bone-regeneration-simultaneous-with-dental-implant-placement-in-the-esthetic-zone
#8
Sirida Arunjaroensuk, Soontra Panmekiate, Atiphan Pimkhaokham
PURPOSE: This randomized controlled clinical trial compared the stability of augmented bone between a synthetic resorbable membrane and a collagen resorbable membrane with guided bone regeneration (GBR) simultaneous with dental implant placement in the esthetic zone in terms of facial bone thickness. MATERIALS AND METHODS: A total of 60 dental implants from patients requiring implant placement with simultaneous GBR in the esthetic zone were equally allocated to the test group or control group by block randomization...
October 13, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29028072/vitamin-d-in-human-reproduction-the-more-the-better-an-evidence-based-critical-appraisal
#9
A S Laganà, S G Vitale, H Ban Frangež, E Vrtačnik-Bokal, R D'Anna
OBJECTIVE: Vitamin D is a fat-soluble secosteroid hormone that regulates calcium, magnesium, and phosphate homeostasis and plays a pivotal role as antiproliferative and immunomodulatory mediator. Considering the different sources of synthesis and dietary intake as well as the pleiotropic actions in extremely diverse (micro)environments of the body, the supplementation of this Vitamin should be carefully evaluated taking into account the several pathways that it regulates. In the current brief review, we aimed to summarize the available evidence about the topic, in order to suggest the best evidence-based supplementation strategy for human reproduction, avoiding the unuseful (and sometimes hazardous) empiric supplementation...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028070/gene-expression-in-human-adipose-derived-stem-cells-comparison-of-2d-films-3d-electrospun-meshes-or-co-cultured-scaffolds-with-two-way-paracrine-effects
#10
S C Hess, W J Stark, D Mohn, N Cohrs, S Märsmann, M Calcagni, P Cinelli, J Buschmann
Finding the appropriate cues to trigger the desired differentiation is a challenge in tissue engineering when stem cells are involved. In this regard, three-dimensional environments are often compared to cells' two-dimensional culture behaviour (plastic culture dish). Here, we compared the gene expression pattern of human adipose-derived stem cells (ASC) seeded in a three-dimensional (3D) electrospun mesh and on a two-dimensional (2D) film - both of exactly the same material. Additionally, we conducted experiments with a scaffold floating above a film to investigate two-way paracrine effects (co-system)...
October 13, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29027620/evaluation-of-the-tolerability-and-efficacy-of-sodium-polystyrene-sulfonate-for-long-term-management-of-hyperkalemia-in-patients-with-chronic-kidney-disease
#11
Panagiotis I Georgianos, Ioannis Liampas, Andreas Kyriakou, Vasilios Vaios, Vasilios Raptis, Nikolaos Savvidis, Athanasios Sioulis, Vassilios Liakopoulos, Elias V Balaskas, Pantelis E Zebekakis
PURPOSE: Sodium polystyrene sulfonate (SPS) is a cation-exchanging resin that has been widely used for several decades as first-line therapy of mild chronic hyperkalemia in patients with chronic kidney disease (CKD). However, evidence to prove the long-term tolerability and efficacy of SPS for the treatment of this condition is still missing. METHODS: In this retrospective, observational study, we enrolled 26 outpatients with stages 3-4 CKD who received oral therapy with low-dose SPS for mild chronic hyperkalemia in the Outpatient Nephrology clinic of our Department during 2010-2016...
October 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29027611/preparation-of-flexible-bone-tissue-scaffold-utilizing-sea-urchin-test-and-collagen
#12
Naga Vijaya Lakshmi Manchinasetty, Sho Oshima, Masanori Kikuchi
Gonads of sea urchin are consumed in Japan and some countries as food and most parts including its tests are discarded as marine wastes. Therefore, utilization of them as functional materials would reduce the waste as well as encourage Japanese fishery. In this study, magnesium containing calcite granules collected from sea urchin tests were hydrothermally phosphatized and the obtained granules were identified as approximately 82% in mass of magnesium containing β-tricalcium phosphate and 18% in mass of nonstoichiometric hydroxyapatite, i...
October 13, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29027248/ursodeoxycholic-acid-protects-cardiomyocytes-against-cobalt-chloride-induced-hypoxia-by-regulating-transcriptional-mediator-of-cells-stress-hypoxia-inducible-factor-1%C3%AE-and-p53-protein
#13
Anis Syamimi Mohamed, Noorul Izzati Hanafi, Siti Hamimah Sheikh Abdul Kadir, Julina Md Noor, Narimah Abdul Hamid Hasani, Sharaniza Ab Rahim, Rosfaiizah Siran
In hepatocytes, ursodeoxycholic acid (UDCA) activates cell signalling pathways such as p53, intracellular calcium ([Ca(2+) ]i ), and sphingosine-1-phosphate (S1P)-receptor via Gαi -coupled-receptor. Recently, UDCA has been shown to protect the heart against hypoxia-reoxygenation injury. However, it is not clear whether UDCA cardioprotection against hypoxia acts through a transcriptional mediator of cells stress, HIF-1α and p53. Therefore, in here, we aimed to investigate whether UDCA could protect cardiomyocytes (CMs) against hypoxia by regulating expression of HIF-1α, p53, [Ca(2+) ]i , and S1P-Gαi -coupled-receptor...
October 12, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29026589/a-retrospective-analysis-of-biochemical-and-haematological-parameters-in-patients-with-eating-disorders
#14
Leanne J Barron, Robert F Barron, Jeremy C S Johnson, Ingrid Wagner, Cameron J B Ward, Shannon R B Ward, Faye M Barron, Warren K Ward
BACKGROUND: The objective of the study was to determine whether levels of biochemical and haematological parameters in patients with eating disorders (EDs) varied from the general population. Whilst dietary restrictions can lead to nutritional deficiencies, specific abnormalities may be relevant to the diagnosis, pathogenesis and treatment of EDs. METHODS: With ethics approval and informed consent, a retrospective chart audit was conducted of 113 patients with EDs at a general practice in Brisbane, Australia...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29025651/hierarchically-porous-structure-mechanical-strength-and-cell-biological-behaviors-of-calcium-phosphate-composite-scaffolds-prepared-by-combination-of-extrusion-and-porogen-burnout-technique-and-enhanced-by-gelatin
#15
Shenglei Feng, Fupo He, Jiandong Ye
In this study, hierarchically porous calcium phosphate scaffolds (HTCP) with unidirectional pores, transversely interconnected pores, and micropores were fabricated by the combination of extrusion and porogen burnout technique. Gelatin was incorporated into the HTCP scaffolds by vacuum-impregnation of gelatin solution and subsequent freeze-drying. The phase composition, microstructure, physical and cytobiological properties were analyzed. The results showed that the HTCP scaffolds were composed of β-tricalcium phosphate with minor hydroxyapatite...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025644/polylactic-acid-based-porous-scaffolds-doped-with-calcium-silicate-and-dicalcium-phosphate-dihydrate-designed-for-biomedical-application
#16
Maria Giovanna Gandolfi, Fausto Zamparini, Micaela Degli Esposti, Federica Chiellini, Conrado Aparicio, Fabio Fava, Paola Fabbri, Paola Taddei, Carlo Prati
Polylactic acid (PLA), dicalcium phosphate dihydrate (DCPD) and/or hydraulic calcium silicate (CaSi) have been used to prepare highly-porous scaffolds by thermally induced phase separation technique (TIPS). Three experimental mineral-doped formulations were prepared (PLA-10CaSi, PLA-5CaSi-5DCPD, PLA-10CaSi-10DCPD). Pure PLA scaffolds constituted the control group. Scaffolds were tested for their chemical-physical and biological properties, namely calcium release, alkalinizing activity, surface microchemistry and micromorphology by ESEM, apatite-forming ability by EDX, micro-Raman and IR spectroscopy, thermal properties by differential scanning calorimetry, mechanical properties by quasi-static parallel-plates compression testing, porosity by a standard water-absorption method and direct-contact cytotoxicity...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025641/polyurethane-foam-nano-hydroxyapatite-composite-as-a-suitable-scaffold-for-bone-tissue-regeneration
#17
M Meskinfam, S Bertoldi, N Albanese, A Cerri, M C Tanzi, R Imani, N Baheiraei, M Farokhi, S Farè
In bone tissue regeneration, the use of biomineralized scaffolds to create the 3D porous structure needed for well-fitting with defect size and appropriate cell interactions, is a promising alternative to autologous and heterologous bone grafts. Biomineralized polyurethane (PU) foams are here investigated as scaffold for bone tissue regeneration. Biomineralization of the foams was carried out by activation of PU surface by a two steps procedure performed for different times (1 to 4 weeks). Scaffolds were investigated for morphological, chemico-physical and mechanical properties, as well as for in vitro interaction with rat Bone Marrow Mesenchymal Stem Cells (BMSCs)...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29024595/organelle-specific-triggered-release-of-immunostimulatory-oligonucleotides-from-intrinsically-coordinated-dna-metal-organic-frameworks-with-soluble-exoskeleton
#18
Zejun Wang, Yao Fu, Zhengzhong Kang, Xiaoguo Liu, Nan Chen, Qi Wang, Yaoquan Tu, Lihua Wang, Shiping Song, Daishun Ling, Haiyun Song, Xueqian Kong, Chunhai Fan
DNA has proven of high utility to modulate the surface functionality of metal-organic frameworks (MOFs) for various biomedical applications. Nevertheless, current methods for preparing DNA-MOF nanoparticles rely on either inefficient covalent conjugation or specific modification of oligonucleotides. In this work, we report that unmodified oligonucleotides can be loaded on MOFs with high density (~2,500 strands/particle) via intrinsic, multivalent coordination between DNA backbone phosphate and unsaturated zirconium sites on MOFs...
October 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29024399/high-magnesium-prevents-matrix-vesicle-mediated-mineralization-in-human-bone-marrow-derived-mesenchymal-stem-cells-via-mitochondrial-pathway-and-autophagy
#19
Yaqiang Li, Jing Wang, Jiaji Yue, Yu Wang, Chunxi Yang, Quanjun Cui
Magnesium, as a physiological calcium antagonist, plays vital role in the bone metabolism and the balance between magnesium and calcium is crucial in bone physiology. We recently demonstrated that matrix mineralization in human bone marrow-derived mesenchymal stem cells (hBMSCs) can be suppressed by high Mg(2+) . However, a complete understanding of the mechanisms involved still remains to be elucidated. As mitochondrial calcium phosphate granules depletion manifests concurrently with the appearance of matrix vesicles (MVs) and autophagy are associated with matrix mineralization, we studied the effect of high extracellular Mg(2+) on these pathways...
October 10, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29023621/bond-strength-of-self-adhering-materials-effect-of-dentin-desensitizing-treatment-with-a-cpp-acp-paste
#20
Fereshteh Shafiei, Reza Derafshi, Mahtab Memarpour
This study investigated the effect of dentin-desensitizing treatment with a casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste on shear bond strength (SBS) of two types of self-adhering (SA) restorative materials: resin-modified glass-ionomer (Fuji II LC, GC) and self-adhering flowable composite resin (Vertise Flow, Kerr). Flat and smear layer-free dentin surfaces from 48 extracted molars were prepared and divided into four groups (n = 12 per group) according to Fuji II LC or Vertise Flow and CPP-ACP pretreatment or not...
November 2017: International Journal of Periodontics & Restorative Dentistry
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