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https://www.readbyqxmd.com/read/28918362/there-are-no-no-responders-to-low-or-high-resistance-training-volumes-among-older-women
#1
Matheus de Siqueira Mendes Barbalho, Paulo Gentil, Mikel Izquierdo, James Fisher, James Steele, Rodolfo de Azevedo Raiol
OBJECTIVES: To assess the prevalence of non-responders to different tests and to compare the effects of different resistance training (RT) volumes on muscle strength, anthropometric and functional performance of older women. METHODS: Three hundred seventy six women performed 12weeks of RT with either low or high volume (LV, 71.29±5.77years and HV 69.73±5.88years, respectively). Both groups performed the same exercises, and all parameters were held constant except for the number of sets performed per week...
September 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28915863/lifestyle-intervention-to-improve-quality-of-life-and-prevent-weight-gain-after-renal-transplantation-design-of-the-active-care-after-transplantation-act-randomized-controlled-trial
#2
Gerald Klaassen, Dorien M Zelle, Gerjan J Navis, Desie Dijkema, Frederike J Bemelman, Stephan J L Bakker, Eva Corpeleijn
BACKGROUND: Low physical activity and reduced physical functioning are common after renal transplantation, resulting in a reduced quality of life. Another common post-transplantation complication is poor cardio-metabolic health, which plays a main role in long-term outcomes in renal transplant recipients (RTR). It is increasingly recognized that weight gain in the first year after transplantation, especially an increase in fat mass, is a highly common contributor to cardio-metabolic risk...
September 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28915265/the-accessory-parotid-gland-and-facial-process-of-the-parotid-gland-on-computed-tomography
#3
Dongbin Ahn, Chang Ki Yeo, Soon Yong Han, Jeong Kyu Kim
The purpose of this study was to determine the incidence of an anterior extension of the parotid gland, such as an accessory parotid gland (APG) or facial process (FP) and to evaluate its characteristics on computed tomography (CT) scans. We reviewed CT scans of 1,600 parotid glands from 800 patients. An APG on CT was defined as a soft-tissue mass of the same density as the main parotid gland, located at the anterior part of the main parotid gland, and completely separate from the main parotid gland. An FP was defined as a lobe of the parotid gland protruding anteriorly over the anterior edge of the ramus of the mandible on CT and showing continuity with the main gland...
2017: PloS One
https://www.readbyqxmd.com/read/28914708/efficacy-of-femiscan-pelvic-floor-therapy-for-the-treatment-of-anal-incontinence
#4
Shimon Segal, Abraham Morse, Purnima Sangal, Nathan Hirsch, Neeraj Kohli
OBJECTIVES: Pelvic floor muscle training can be effective in alleviating anal incontinence; however, women need instruction, motivation, and feedback to gain optimal benefit. The FemiScan Pelvic Floor Therapy System is approved in the United States and European Union for the treatment of urinary incontinence. It uses office electromyography and an in-home programmable device. This study was undertaken to document the effect of FemiScan on anal incontinence symptoms of women who completed a physician-supervised program...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28912923/lack-of-needs-assessment-in-cancer-survivorship-care-and-rehabilitation-in-hospitals-and-primary-care-settings
#5
Charlotte Handberg, Charlotte Maria Jensen, Thomas Maribo
BACKGROUND: Formalized and systematic assessment of survivorship care and rehabilitation needs is prerequisite for ensuring cancer patients sufficient help and support through their cancer trajectory. Patients are often uncertain as to how to express and address their survivorship care and rehabilitation needs, and little is known about specific, unmet needs and the plans necessary to meet them. There is a call for both ensuring survivorship care and rehabilitation for cancer patients in need and further for documenting the specific needs related to the cancer disease and its treatment...
October 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28912657/moderate-intensity-cycling-exercise-after-upper-extremity-resistance-training-interferes-response-to-muscle-hypertrophy-but-not-strength-gains
#6
Shigeto Tomiya, Naoki Kikuchi, Koichi Nakazato
The purpose of the present study was to examine the effect of 30-min moderate intensity cycling exercise immediately after upper-body resistance training on the muscle hypertrophy and strength gain. Fourteen subjects were randomly divided between two groups. One group performed moderate intensity (55% of maximum oxygen consumption [VO2max], 30 min) cycle training immediately after arm resistance training as concurrent training (CT; n = 7, age: 21.8 ± 0.7 years, height: 1.68 ± 0.06 m, weight: 60.3 ± 7.4 kg); the second group performed the same endurance and arm RT on separate days as control group (SEP; n=7, age: 22...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28912570/a-focus-on-extracellular-ca-2-entry-into-skeletal-muscle
#7
REVIEW
Chung-Hyun Cho, Jin Seok Woo, Claudio F Perez, Eun Hui Lee
The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca(2+) in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca(2+) level is mainly determined by Ca(2+) movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca(2+) entry from extracellular spaces to the cytosol has gained significant attention over the past decade...
September 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28911175/hyperandrogenemia-induced-by-letrozole-treatment-of-pubertal-female-mice-results-in-hyperinsulinemia-prior-to-weight-gain-and-insulin-resistance
#8
Danalea V Skarra, Angelina Hernández-Carretero, Alissa J Rivera, Arya R Anvar, Varykina G Thackray
Women with polycystic ovary syndrome (PCOS) diagnosed with hyperandrogenism and ovulatory dysfunction have an increased risk of developing metabolic disorders, including type 2 diabetes and cardiovascular disease. We previously developed a model that uses letrozole to elevate endogenous testosterone levels in female mice. This model has hallmarks of PCOS, including hyperandrogenism, anovulation, and polycystic ovaries, as well as increased abdominal adiposity and glucose intolerance. In the current study, we further characterized the metabolic dysfunction that occurs after letrozole treatment to determine whether this model represents a PCOS-like metabolic phenotype...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28905107/effect-of-changes-of-femoral-offset-on-abductor-and-joint-reaction-forces-in-total-hip-arthroplasty
#9
Hannes A Rüdiger, Maïka Guillemin, Adeliya Latypova, Alexandre Terrier
BACKGROUND: Anatomical reconstruction in total hip arthroplasty (THA) allows for physiological muscle function, good functional outcome and implant longevity. Quantitative data on the effect of a loss or gain of femoral offset (FO) are scarce. The aim of this study was to quantitatively describe the effect of FO changes on abductor moment arms, muscle and joint reactions forces. METHODS: THA was virtually performed on 3D models built from preoperative CT scans of 15 patients undergoing THA...
September 13, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28904108/comparison-of-three-models-of-saccade-disconjugacy-in-strabismus
#10
Mark M G Walton, Michael J Mustari
In pattern strabismus the horizontal and vertical misalignments vary with eye position along the orthogonal axis. The disorder is typically described in terms of overaction or underaction of oblique muscles. Recent behavioral studies in humans and monkeys, however, have reported that such actions are insufficient to fully explain the patterns of directional and amplitude disconjugacy of saccades. There is mounting evidence that the oculomotor abnormalities associated with strabismus are at least partially attributable to neurophysiological abnormalities...
September 13, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28899845/upwelling-derived-oceanographic-conditions-impact-growth-performance-and-growth-related-gene-expression-in-intertidal-fish
#11
Eduardo N Fuentes, Rodrigo Zuloaga, Oscar Almarza, Katterinne Mendez, Juan Antonio Valdés, Alfredo Molina, Jose Pulgar
Growth is one of the main biological processes in aquatic organisms that is affected by environmental fluctuations such as upwelling (characterized by food-rich waters). In fish, growth is directly related with skeletal muscle increase; which represents the largest tissue of body mass. However, the effects of upwelling on growth, at the physiological and molecular level, are unknown. This study used Girella laevifrons (one of the most abundant intertidal fish in Eastern South Pacific) as a biological model, considering animals from upwelling (U) and non-upwelling (NU) areas...
September 9, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28890833/gender-success-and-drop-out-during-a-resistance-exercise-program-in-community-dwelling-old-adults
#12
O G Geirsdottir, M Chang, K Briem, P V Jonsson, I Thorsdottir, A Ramel
BACKGROUND: Resistance exercise training can be effective against sarcopenia. We identified predictors of drop-out and compared physical outcomes between men and women after such training. METHODS: Subjects (N = 236, 73.7 ± 5.7 years) participated in a 12-week resistance exercise program. Outcome variables were measured at baseline and endpoint. RESULTS: Drop-out was 11.9% and not significantly different between genders. Drop-outs were significantly older and had poorer strength and physical function in comparison to completers...
2017: Journal of Aging Research
https://www.readbyqxmd.com/read/28887840/pre-clinical-evaluation-of-n-acetylcysteine-reveals-side-effects-in-the-mdx-mouse-model-of-duchenne-muscular-dystrophy
#13
Gavin J Pinniger, Jessica R Terrill, Evanna B Assan, Miranda D Grounds, Peter G Arthur
Duchenne Muscular Dystrophy (DMD) is a fatal X-linked muscle wasting disease characterised by severe muscle weakness, necrosis, inflammation and oxidative stress. The antioxidant N-acetylcysteine (NAC) has been proposed as a potential therapeutic intervention for DMD boys. We investigated the capacity of NAC to improve dystrophic muscle function in the mdx mouse model of DMD. Young (6 w old) mdx and non-dystrophic C57 mice receiving 2% NAC in drinking water for 6 w were compared with untreated mice. Grip strength and body weight were measured weekly, before the 12 w old mice were anaesthetized and extensor digitorum longus (EDL) muscles excised for functional analysis and tissues sampled for biochemical analyses...
September 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28883916/circulating-leptin-and-its-muscle-gene-expression-in-nellore-cattle-with-divergent-feed-efficiency
#14
Lúcio Flávio Macedo Mota, Cristina Moreira Bonafé, Pâmela Almeida Alexandre, Miguel Henrique Santana, Francisco José Novais, Erika Toriyama, Aldrin Vieira Pires, Saulo da Luz Silva, Paulo Roberto Leme, José Bento Sterman Ferraz, Heidge Fukumasu
BACKGROUND: Leptin has a strong relation to important traits in animal production, such as carcass composition, feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus. In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake (DMI) and average daily gain (ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake (RFI) and select 20 animals for the high feed efficient (LRFI) and 20 for the low feed efficient (HRFI) groups...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28883792/antidiabetic-effect-of-tibetan-medicine-tang-kang-fu-san-in-db-db-mice-via-activation-of-pi3k-akt-and-ampk-pathways
#15
Bailu Duan, Zhongqiu Zhao, Weifang Liao, Hui Xiong, Sisi Liu, Liang Yin, Tiexiang Gao, Zhinan Mei
This study was to investigate the anti-diabetic effects and molecular mechanisms of Tang-Kang-Fu-San (TKFS), a traditional Tibetan medicine, in treating type 2 diabetes mellitus of spontaneous diabetic db/db mice. Firstly HPLC fingerprint analysis was performed to gain the features of the chemical compositions of TKFS. Next different doses of TKFS (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) were administrated via oral gavage to db/db mice and their controls for 4 weeks. TKFS significantly lowered hyperglycemia and ameliorated insulin resistance (IR) in db/db mice, indicated by results from multiple tests, including fasting blood glucose test, intraperitoneal insulin and glucose tolerance tests, fasting serum insulin levels and homeostasis model assessment of IR analysis as well as histology of pancreas islets...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28883046/case-studies-in-physiology-skeletal-muscle-mitochondrial-protein-synthesis-and-respiration-in-response-to-the-energetic-stress-of-an-ultra-endurance-race
#16
Adam R Konopka, William M Castor, Christopher A Wolff, Robert V Musci, Justin J Reid, Jaime L Laurin, Zackary J Valenti, Karyn L Hamilton, Benjamin F Miller
The 2016 Colorado Trail Race (CTR) was an ultra-endurance mountain bike race where competitors cycled for up to 24 hrs/day between altitudes of 1675 to 4025 meters to complete 800 kilometers and 21,000 meters of elevation gain. In one athlete, we had the unique opportunity to characterize skeletal muscle protein synthesis and mitochondrial respiration in response to a normal activity control period (CON) and the CTR. We hypothesized that mitochondrial protein synthesis would be elevated and mitochondrial respiration would be maintained during the extreme stresses of the CTR...
September 7, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28882330/combining-muscle-synergies-and-biomechanical-analysis-to-assess-gait-in-stroke-patients
#17
Filipe O Barroso, Diego Torricelli, Francisco Molina-Rueda, Isabel M Alguacil-Diego, Roberto Cano-de-la-Cuerda, Cristina Santos, Juan C Moreno, Juan C Miangolarra-Page, José L Pons
The understanding of biomechanical deficits and impaired neural control of gait after stroke is crucial to prescribe effective customized treatments aimed at improving walking function. Instrumented gait analysis has been increasingly integrated into the clinical practice to enhance precision and inter-rater reliability for the assessment of pathological gait. On the other hand, the analysis of muscle synergies has gained relevance as a novel tool to describe the neural control of walking. Since muscle synergies and gait analysis capture different but equally important aspects of walking, we hypothesized that their combination can improve the current clinical tools for the assessment of walking performance...
August 20, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28881481/oxaliplatin-induces-muscle-loss-and-muscle-specific-molecular-changes-in-mice
#18
Claire E Feather, Justin G Lees, Preet G S Makker, David Goldstein, John B Kwok, Gila Moalem-Taylor, Patsie Polly
INTRODUCTION: Muscle wasting is a frequent, debilitating complication of cancer. The impact of colorectal cancer chemotherapeutic oxaliplatin on the development of muscle loss and associated molecular changes is of clinical importance. METHODS: C57BL/6J male mice were treated with oxaliplatin. Total body weights were measured and behavioral studies performed. Hindlimb muscle weights (gastrocnemius and soleus) were recorded in conjunction with gene and protein expression analysis...
September 7, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28880277/use-of-a-neonatal-rat-system-as-a-bioincubator-to-generate-adult-like-mature-cardiomyocytes-from-human-and-mouse-pluripotent-stem-cells
#19
Gun-Sik Cho, Emmanouil Tampakakis, Peter Andersen, Chulan Kwon
Pluripotent stem cells (PSCs), including induced PSCs, hold great potential for personalized disease modeling, drug testing and cell-based therapeutics. However, cells differentiated from PSCs remain immature in a dish, and thus there are serious caveats to their use in modeling adult-onset diseases such as cardiomyopathies and Alzheimer's disease. By taking advantage of knowledge gained about mammalian development and from bioinformatics analyses, we recently developed a neonatal rat system that enables maturation of PSC-derived cardiomyocytes into cardiomyocytes analogous to those seen in adult animals...
October 2017: Nature Protocols
https://www.readbyqxmd.com/read/28878673/review-of-the-reported-measures-of-clinical-validity-and-clinical-utility-as-arguments-for-the-implementation-of-pharmacogenetic-testing-a-case-study-of-statin-induced-muscle-toxicity
#20
REVIEW
Marleen E Jansen, T Rigter, W Rodenburg, T M C Fleur, E J F Houwink, M Weda, Martina C Cornel
Advances from pharmacogenetics (PGx) have not been implemented into health care to the expected extent. One gap that will be addressed in this study is a lack of reporting on clinical validity and clinical utility of PGx-tests. A systematic review of current reporting in scientific literature was conducted on publications addressing PGx in the context of statins and muscle toxicity. Eighty-nine publications were included and information was selected on reported measures of effect, arguments, and accompanying conclusions...
2017: Frontiers in Pharmacology
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