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https://www.readbyqxmd.com/read/28944730/optimization-of-medication-use-at-accountable-care-organizations
#1
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28943723/new-insights-into-the-development-of-human-tool-use
#2
Jeffrey J Lockman, Björn A Kahrs
If tool use requires higher-level cognitive abilities, how is it that many animals show the capacity to use tools? New research on the development of human tool use offers a way to resolve this paradox. The research suggests that there is a developmental synergy between affordance detection and motor learning: As juveniles continually explore affordances entailed by object-surface combinations in real time, they tune the actions that will be incorporated into tool use over developmental time. We illustrate these ideas with research on how object banging in infancy serves as the motor substrate for later developing percussive tool use...
August 2017: Current Directions in Psychological Science
https://www.readbyqxmd.com/read/28943199/effects-of-the-dimeric-psd-95-inhibitor-uccb01-144-on-functional-recovery-after-fimbria-fornix-transection-in-rats
#3
Jens Bak Sommer, Anders Bach, Hana Malá, Kristian Strømgaard, Jesper Mogensen, Darryl S Pickering
Pharmacological inhibition of PSD-95 is a promising therapeutic strategy in the treatment of stroke, and positive effects of monomeric and dimeric PSD-95 inhibitors have been reported in numerous studies. However, whether therapeutic effects will generalize to other types of acute brain injury such as traumatic brain injury (TBI), which has pathophysiological mechanisms in common with stroke, is currently uncertain. We have previously found a lack of neuroprotective effects of dimeric PSD-95 inhibitors in the controlled cortical impact model of TBI in rats...
September 21, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28942119/21st-century-neurobehavioral-theories-of-decision-making-in-addiction-review-and-evaluation
#4
REVIEW
Warren K Bickel, Alexandra M Mellis, Sarah E Snider, Liqa N Athamneh, Jeffrey S Stein, Derek A Pope
This review critically examines neurobehavioral theoretical developments in decision making in addiction in the 21st century. We specifically compare each theory reviewed to seven benchmarks of theoretical robustness, based on their ability to address: why some commodities are addictive; developmental trends in addiction; addiction-related anhedonia; self-defeating patterns of behavior in addiction; why addiction co-occurs with other unhealthy behaviors; and, finally, means for the repair of addiction. We have included only self-contained theories or hypotheses which have been developed or extended in the 21st century to address decision making in addiction...
September 20, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28941818/a-comparison-of-4-predictive-models-of-calving-assistance-and-difficulty-in-dairy-heifers-and-cows
#5
Caroline Fenlon, Luke O'Grady, John F Mee, Stephen T Butler, Michael L Doherty, John Dunnion
The aim of this study was to build and compare predictive models of calving difficulty in dairy heifers and cows for the purpose of decision support and simulation modeling. Models to predict 3 levels of calving difficulty (unassisted, slight assistance, and considerable or veterinary assistance) were created using 4 machine learning techniques: multinomial regression, decision trees, random forests, and neural networks. The data used were sourced from 2,076 calving records in 10 Irish dairy herds. In total, 19...
September 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28941415/manganese-in-teeth-and-neurobehavior-sex-specific-windows-of-susceptibility
#6
Julia Anglen Bauer, Birgit Claus Henn, Christine Austin, Silvia Zoni, Chiara Fedrighi, Giuseppa Cagna, Donatella Placidi, Roberta F White, Qiong Yang, Brent A Coull, Donald Smith, Roberto G Lucchini, Robert O Wright, Manish Arora
BACKGROUND: Manganese (Mn) is an essential element required for growth and development, but higher body burdens have been associated with neurobehavioral decrements in children. OBJECTIVES: We examined whether prenatal or postnatal Mn measured in deciduous teeth was associated with scores on a test of visuospatial learning and memory. METHODS: Deciduous teeth were collected from 142 participants (ages 10-14years) residing near varied ferro‑manganese industry in Italy...
September 20, 2017: Environment International
https://www.readbyqxmd.com/read/28941380/using-virtual-environments-to-investigate-wayfinding-in-8-to-12-year-olds-and-adults
#7
Jamie Lingwood, Mark Blades, Emily K Farran, Yannick Courbois, Danielle Matthews
Wayfinding is the ability to learn and recall a route through an environment. Theories of wayfinding suggest that for children to learn a route successfully, they must have repeated experience of it, but in this experiment we investigated whether children could learn a route after only a single experience of the route. A total of 80 participants from the United Kingdom in four groups of 20 8-year-olds, 10-year-olds, 12-year-olds, and adults were shown a route through a 12-turn maze in a virtual environment...
September 20, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28940848/executive-function-and-functional-and-structural-brain-differences-in-middle-age-adults-with-autism-spectrum-disorder
#8
B Blair Braden, Christopher J Smith, Amiee Thompson, Tyler K Glaspy, Emily Wood, Divya Vatsa, Angela E Abbott, Samuel C McGee, Leslie C Baxter
There is a rapidly growing group of aging adults with autism spectrum disorder (ASD) who may have unique needs, yet cognitive and brain function in older adults with ASD is understudied. We combined functional and structural neuroimaging and neuropsychological tests to examine differences between middle-aged men with ASD and matched neurotypical (NT) men. Participants (ASD, n = 16; NT, n = 17) aged 40-64 years were well-matched according to age, IQ (range: 83-131), and education (range: 9-20 years)...
September 21, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28940086/music-related-reward-responses-predict-episodic-memory-performance
#9
Laura Ferreri, Antoni Rodriguez-Fornells
Music represents a special type of reward involving the recruitment of the mesolimbic dopaminergic system. According to recent theories on episodic memory formation, as dopamine strengthens the synaptic potentiation produced by learning, stimuli triggering dopamine release could result in long-term memory improvements. Here, we behaviourally test whether music-related reward responses could modulate episodic memory performance. Thirty participants rated (in terms of arousal, familiarity, emotional valence, and reward) and encoded unfamiliar classical music excerpts...
September 22, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28939668/neurogranin-a-synaptic-protein-is-associated-with-memory-independent-of-alzheimer-biomarkers
#10
Kaitlin B Casaletto, Fanny M Elahi, Brianne M Bettcher, John Neuhaus, Barbara B Bendlin, Sanjay Asthana, Sterling C Johnson, Kristine Yaffe, Cynthia Carlsson, Kaj Blennow, Henrik Zetterberg, Joel H Kramer
OBJECTIVE: To determine the association between synaptic functioning as measured via neurogranin in CSF and cognition relative to established Alzheimer disease (AD) biomarkers in neurologically healthy older adults. METHODS: We analyzed CSF concentrations of neurogranin, β-amyloid (Aβ42), phosphorylated tau (p-tau), and total tau (t-tau) among 132 neurologically normal older adults (mean 64.5, range 55-85), along with bilateral hippocampal volumes and a measure of episodic memory (Auditory Verbal Learning Test, delayed recall)...
September 22, 2017: Neurology
https://www.readbyqxmd.com/read/28939446/next-generation-terminology-infrastructure-to-support-interprofessional-care-planning
#11
Sarah Collins, Stephanie Klinkenberg-Ramirez, Kira Tsivkin, Perry L Mar, Dina Iskhakova, Hari Nandigam, Lipika Samal, Roberto A Rocha
OBJECTIVE: Develop a prototype of an interprofessional terminology and information model infrastructure that can enable care planning applications to facilitate patient-centered care, learn care plan linkages and associations, provide decision support, and enable automated, prospective analytics. DESIGN: The study steps included a 3 step approach: 1) Process model and clinical scenario development, and 2) Requirements analysis, and 3) Development and validation of information and terminology models...
September 19, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28938179/does-simulation-enhance-nurses-ability-to-assess-deteriorating-patients
#12
Maria Bliss, Leanne M Aitken
Recognising and responding to patient deterioration has been identified as a key skill in nursing care to ensure that care is escalated for prompt, efficient management of the potentially critically ill patient. Simulation is one teaching strategy that has been established in nurse education as a method for enhancing skills. The objective was to explore the experiences of registered nurses to ascertain whether they perceived that simulation enhanced their skills in recognising the deteriorating patient. An exploratory qualitative design was used...
September 12, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28938078/online-lactation-education-for-healthcare-providers-a-theoretical-approach-to-understanding-learning-outcomes
#13
Amanda L Watkins, Joan E Dodgson, Darya Bonds McClain
BACKGROUND: Breastfeeding competencies are not standardized in healthcare education for any of the health professions. A few continuing education/professional development programs have been implemented, but research regarding the efficacy of these programs is scarce. Research aim: After a 45-hour lactation course, (a) Does breastfeeding knowledge increase? (b) Do beliefs and attitudes about infant feeding improve? (c) Does perceived behavioral control over performance of evidence-based lactation support practices increase? and (d) Do intentions to carry out evidence-based lactation support practices increase? METHODS: A nonexperimental pretest-posttest self-report survey design was conducted with a nonprobability sample of participants ( N = 71) in a lactation course...
September 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28937789/identifying-dyslexia-risk-in-student-athletes-a-preliminary-protocol-for-concussion-management
#14
Rebecca Wiseheart, Robin Wellington
Learning disability (LD) has been identified as a potential risk factor for protracted recovery from a sport-related concussion, yet students with LD are rarely included in concussion research. Here, we draw special attention to dyslexia, a common but often underdiagnosed LD. Reading and learning problems commonly associated with dyslexia are often masked by protective factors, such as high verbal ability or general intelligence. Hence, high-achieving individuals with dyslexia may not be identified as being in a high-risk category...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937647/identification-of-dna-binding-proteins-using-mixed-feature-representation-methods
#15
Kaiyang Qu, Ke Han, Song Wu, Guohua Wang, Leyi Wei
DNA-binding proteins play vital roles in cellular processes, such as DNA packaging, replication, transcription, regulation, and other DNA-associated activities. The current main prediction method is based on machine learning, and its accuracy mainly depends on the features extraction method. Therefore, using an efficient feature representation method is important to enhance the classification accuracy. However, existing feature representation methods cannot efficiently distinguish DNA-binding proteins from non-DNA-binding proteins...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937608/assessment-of-clicker-training-for-shelter-cats
#16
Lori Kogan, Cheryl Kolus, Regina Schoenfeld-Tacher
Clicker training has the potential to mitigate stress among shelter cats by providing environmental enrichment and human interaction. This study assessed the ability of cats housed in a shelter-like setting to learn new behaviors via clicker training in a limited amount of time. One hundred shelter cats were enrolled in the study. Their baseline ability to perform four specific behaviors touching a target, sitting, spinning, and giving a high-five was assessed, before exposing them to 15, five-min clicker training sessions, followed by a post-training assessment...
September 22, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28937300/infants-processing-of-prosodic-cues-electrophysiological-evidence-for-boundary-perception-beyond-pause-detection
#17
Julia Holzgrefe-Lang, Caroline Wellmann, Barbara Höhle, Isabell Wartenburger
Infants as young as six months are sensitive to prosodic phrase boundaries marked by three acoustic cues: pitch change, final lengthening, and pause. Behavioral studies suggest that a language-specific weighting of these cues develops during the first year of life; recent work on German revealed that eight-month-olds, unlike six-month-olds, are capable of perceiving a prosodic boundary on the basis of pitch change and final lengthening only. The present study uses Event-Related Potentials (ERPs) to investigate the neuro-cognitive development of prosodic cue perception in German-learning infants...
September 1, 2017: Language and Speech
https://www.readbyqxmd.com/read/28936646/apomixis-engineering-the-ability-to-harness-hybrid-vigor-in-crop-plants
#18
Joann A Conner, Peggy Ozias-Akins
Apomixis, commonly defined as asexual reproduction through seed, is a reproductive trait that occurs in only a few minor crops, but would be highly valuable in major crops. Apomixis results in seed-derived progenies that are genetically identical to their maternal parent. The advantage of apomixis would lie in seed propagation of elite food, feed, and biofuel crops that are heterozygous such as hybrid corn and switchgrass or self-pollinating crops for which no commercial-scale hybrid production system is available...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28936494/detection-of-intracranial-hypertension-using-deep-learning
#19
Benjamin Quachtran, Robert Hamilton, Fabien Scalzo
Intracranial Hypertension, a disorder characterized by elevated pressure in the brain, is typically monitored in neurointensive care and diagnosed only after elevation has occurred. This reaction-based method of treatment leaves patients at higher risk of additional complications in case of misdetection. The detection of intracranial hypertension has been the subject of many recent studies in an attempt to accurately characterize the causes of hypertension, specifically examining waveform morphology. We investigate the use of Deep Learning, a hierarchical form of machine learning, to model the relationship between hypertension and waveform morphology, giving us the ability to accurately detect presence hypertension...
December 2016: Proceedings of the ... IAPR International Conference on Pattern Recognition
https://www.readbyqxmd.com/read/28936164/sodium-arsenite-induced-learning-and-memory-impairment-is-associated-with-endoplasmic-reticulum-stress-mediated-apoptosis-in-rat-hippocampus
#20
Hongna Sun, Yanmei Yang, Hanwen Shao, Weiwei Sun, Muyu Gu, Hui Wang, Lixin Jiang, Lisha Qu, Dianjun Sun, Yanhui Gao
Chronic arsenic exposure has been associated to cognitive deficits. However, mechanisms remain unknown. The present study investigated the neurotoxic effects of sodium arsenite in drinking water over different dosages and time periods. Based on results from the Morris water maze (MWM) and morphological analysis, an exposure to sodium arsenite could induce neuronal damage in the hippocampus, reduce learning ability, and accelerate memory impairment. Sodium arsenite significantly increased homocysteine levels in serum and brain...
2017: Frontiers in Molecular Neuroscience
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