keyword
https://read.qxmd.com/read/38534490/deep-learning-for-generalized-eeg-seizure-detection-after-hypoxia-ischemia-preclinical-validation
#1
JOURNAL ARTICLE
Hamid Abbasi, Joanne O Davidson, Simerdeep K Dhillon, Kelly Q Zhou, Guido Wassink, Alistair J Gunn, Laura Bennet
Brain maturity and many clinical treatments such as therapeutic hypothermia (TH) can significantly influence the morphology of neonatal EEG seizures after hypoxia-ischemia (HI), and so there is a need for generalized automatic seizure identification. This study validates efficacy of advanced deep-learning pattern classifiers based on a convolutional neural network (CNN) for seizure detection after HI in fetal sheep and determines the effects of maturation and brain cooling on their accuracy. The cohorts included HI-normothermia term ( n = 7), HI-hypothermia term ( n = 14), sham-normothermia term ( n = 5), and HI-normothermia preterm ( n = 14) groups, with a total of >17,300 h of recordings...
February 24, 2024: Bioengineering
https://read.qxmd.com/read/38532440/anatomical-and-functional-changes-of-the-fetal-adrenal-gland-in-intrauterine-growth-restriction
#2
JOURNAL ARTICLE
Serena Martinelli, Alessandro Rolfo, Carlotta Pace, Letizia Canu, Anna Maria Nuzzo, Domenica Giuffrida, Pietro Gaglioti, Tullia Todros
OBJECTIVE: The aim of this study was to demonstrate the establishment of adrenal sparing in intrauterine growth restricted (IUGR) human fetuses. IUGR fetuses are a subgroup of small for gestational age (SGA) fetuses that are unable to reach their own growth potential because of chronic hypoxia and undernutrition. We hypothesized that in IUGR fetuses the adrenal gland is relatively larger and secretion of noradrenaline (NA), adrenaline (A), and cortisol is increased. STUDY DESIGN: This is a prospective observational study including 65 singleton pregnancies (42 IUGR and 23 controls)...
March 26, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38520695/surviving-birth-at-high-altitude
#3
JOURNAL ARTICLE
Alexandra Heath-Freudenthal, Alejandra Estrada, Inge von Alvensleben, Colleen G Julian
This Symposium Review examines challenges to surviving birth and infancy at high altitudes. Chronic exposure to the environmental hypoxia of high altitudes increases the incidence of maternal vascular disorders of pregnancy characterized by placental insufficiency, restricted fetal growth and preterm delivery, and impairs pulmonary vascular health during infancy. While each condition independently contributes to excess morbidity and mortality in early life, evidence indicates vascular disorders of pregnancy and infantile pulmonary vascular dysfunction are intertwined...
March 23, 2024: Journal of Physiology
https://read.qxmd.com/read/38519795/perinatal-compromise-affects-development-form-and-function-of-the-hippocampus-part-two-preclinical-studies
#4
REVIEW
Tegan A White, Suzanne L Miller, Amy E Sutherland, Beth J Allison, Emily J Camm
The hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional regulation, learning, memory, and cognition. Hippocampal development is exquisitely sensitive to perturbations and adverse conditions during pregnancy and at birth, including preterm birth, fetal growth restriction (FGR), acute hypoxic-ischaemic encephalopathy (HIE), and intrauterine inflammation. Disruptions to hippocampal development due to these conditions can have long-lasting functional impacts...
March 22, 2024: Pediatric Research
https://read.qxmd.com/read/38491313/appropriate-glycemic-management-protects-the-germline-but-not-the-uterine-environment-in-hyperglycemia
#5
JOURNAL ARTICLE
Allan Zhao, Hong Jiang, Arturo Reyes Palomares, Alice Larsson, Wenteng He, Jacob Grünler, Xiaowei Zheng, Kenny A Rodriguez Wallberg, Sergiu-Bogdan Catrina, Qiaolin Deng
Emerging evidence indicates that parental diseases can impact the health of subsequent generations through epigenetic inheritance. Recently, it was shown that maternal diabetes alters the metaphase II oocyte transcriptome, causing metabolic dysfunction in offspring. However, type 1 diabetes (T1D) mouse models frequently utilized in previous studies may be subject to several confounding factors due to severe hyperglycemia. This limits clinical translatability given improvements in glycemic control for T1D subjects...
March 15, 2024: EMBO Reports
https://read.qxmd.com/read/38490241/evaluation-of-cerebral-autoregulation-of-oxygen-by-nirs-method-during-postnatal-transition-period-in-term-and-late-preterm-newborns-without-resuscitation-requirement
#6
JOURNAL ARTICLE
Omer Ertekin, Mehmet Buyuktiryaki, Sehribanu Isik, Nilufer Okur, Serife Suna Oguz
BACKGROUND: Pulse oximetry is commonly used to monitor arterial oxygen saturation and heart rate during the transition period and reference intervals have been determined. However, the effect of the change in arterial oxygen saturation on tissue oxygenation does not seem to be the same. So, a non-invasive method for monitoring cerebral or regional tissue oxygenation will be potentially useful for vulnerable infants. This study aims to evaluate the effectiveness of cerebral autoregulation in the first 10 min after delivery in term and late preterm newborns without resuscitation requirement...
February 7, 2024: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38489990/machine-learning-on-cardiotocography-data-to-classify-fetal-outcomes-a-scoping-review
#7
REVIEW
Farah Francis, Saturnino Luz, Honghan Wu, Sarah J Stock, Rosemary Townsend
INTRODUCTION: Uterine contractions during labour constrict maternal blood flow and oxygen delivery to the developing baby, causing transient hypoxia. While most babies are physiologically adapted to withstand such intrapartum hypoxia, those exposed to severe hypoxia or with poor physiological reserves may experience neurological injury or death during labour. Cardiotocography (CTG) monitoring was developed to identify babies at risk of hypoxia by detecting changes in fetal heart rate (FHR) patterns...
March 7, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38465746/melatonin-protects-oogenesis-from-hypobaric-hypoxia-induced-fertility-damage-in-mice
#8
JOURNAL ARTICLE
Ruina Zhang, Cong Liu, Daolun Yu, Deyong She, Yan Yu, Yongping Cai, Naifu Chen
Environmental hypoxia adversely affects reproductive health in humans and animals at high altitudes. Therefore, how to alleviate the follicle development disorder caused by hypoxia exposure and to improve the competence of fertility in plateau non-habituated female animals are important problems to be solved urgently. In this study, a hypobaric hypoxic chamber was used for 4 weeks to simulate hypoxic conditions in female mice, and the effects of hypoxia on follicle development, proliferation and apoptosis of granulosa cells, reactive oxygen species (ROS) levels in MII oocyte and 2-cell rate were evaluated...
March 11, 2024: Zygote: the Biology of Gametes and Early Embryos
https://read.qxmd.com/read/38462207/mettl3-promotes-trophoblast-ferroptosis-in-preeclampsia-by-stabilizing-the-acsl4-m-6-a-modification
#9
JOURNAL ARTICLE
Yang Wang, Gang Zhang, Yan Gao, Xuemei Zhang, Hongbo Qi
This study aims to explore the role of methyltransferase-like 3 (METTL3) modulation of ferroptosis in the pathogenesis of trophoblast-mediated preeclampsia. The expression of METTL3 and acyl-CoA synthetase long chain family member 4 (ACSL4) was measured in clinical placental tissues and trophoblasts using qPCR and Western blot techniques. The effects of METTL3 on the symptoms of preeclampsia were also validated in rat models. METTL3 and ACSL4 were upregulated in placental tissues from patients with preeclampsia and in hypoxia-induced trophoblasts...
March 8, 2024: Experimental Cell Research
https://read.qxmd.com/read/38436066/changes-in-regional-tissue-oxygen-saturation-values-during-the-first-week-of-life-in-stable-preterm-infants
#10
JOURNAL ARTICLE
Sadaf H Kazmi, Sourabh Verma, Sean M Bailey, Pradeep Mally, Purnahamsi Desai
OBJECTIVES: Near infrared spectroscopy (NIRS) is a non-invasive method for monitoring regional tissue oxygen saturation (rSO2 ). The purpose of this study is to investigate the changes that occur in cerebral, splanchnic, and renal rSO2 and fractional tissue oxygen extraction (FTOE) in stable preterm infants in the first week of life. METHODS: Prospective observational study of infants born 30-34 weeks gestation at NYU Langone Health between November 2017 and November 2018...
March 5, 2024: Journal of Perinatal Medicine
https://read.qxmd.com/read/38432700/acute-respiratory-failure-in-pregnancy
#11
REVIEW
Stephen E Lapinsky, Daniela N Vasquez
Respiratory failure may affect up to 1 in 500 pregnancies, due to pregnancy-specific conditions, conditions aggravated by the pregnant state, or other causes. Management during pregnancy is influenced by altered maternal physiology, and the presence of a fetus influencing imaging, and drug therapy choices. Few studies have addressed the approach to invasive mechanical ventilatory management in pregnancy. Hypoxemia is likely harmful to the fetus, but precise targets are unknown. Hypocapnia reduces uteroplacental circulation, and some degree of hypercapnia may be tolerated in pregnancy...
April 2024: Critical Care Clinics
https://read.qxmd.com/read/38432420/is-it-time-to-end-the-use-of-base-deficit-for-fetal-well-being-assessment
#12
JOURNAL ARTICLE
Thierry Daboval, Paul Ouellet, Claude Racinet
Authors have expressed reservations regarding the use of base deficit on umbilical artery blood samples to assess fetal well-being during the course of labor and predict neonatal neurological morbidity. Despite its integration into clinical practice for over fifty years, obstetricians and maternal fetal medicine specialists may not realize that this marker has significant limitations in accurately assess identifying neonatal metabolic acidosis as a proxy of fetal well-being. In brief, there are two large family of base deficit: whole blood and extracellular fluid...
March 1, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38415649/dysmaturation-of-sleep-state-and-electroencephalographic-activity-after-hypoxia-ischaemia-in-preterm-fetal-sheep
#13
JOURNAL ARTICLE
Christopher A Lear, Benjamin A Lear, Joanne O Davidson, Victoria J King, Yoshiki Maeda, Alice McDouall, Simerdeep K Dhillon, Alistair J Gunn, Laura Bennet
Antenatal hypoxia-ischaemia (HI) in preterm fetal sheep can trigger delayed evolution of severe, cystic white matter injury (WMI), in a similar timecourse to WMI in preterm infants. We therefore examined how severe hypoxia-ischaemia affects recovery of electroencephalographic (EEG) activity. Chronically instrumented preterm fetal sheep (0.7 gestation) received 25 min of complete umbilical cord occlusion (UCO, n = 9) or sham occlusion (controls, n = 9), and recovered for 21 days...
February 28, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38408955/the-application-of-the-icd-10-for-antepartum-stillbirth-patients-in-a-referral-centre-of-eastern-china-a-retrospective-study-from-2015-to-2022
#14
JOURNAL ARTICLE
Chuan-Shou Feng, Shu-Fen Li, Hui-Hui Ju
BACKGROUND: The causes of some stillbirths are unclear, and additional work must be done to investigate the risk factors for stillbirths. OBJECTIVE: To apply the International Classification of Disease-10 (ICD-10) for antepartum stillbirth at a referral center in eastern China. METHODS: Antepartum stillbirths were grouped according to the cause of death according to the International Classification of Disease-10 (ICD-10) criteria. The main maternal condition at the time of antepartum stillbirth was assigned to each patient...
February 26, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38408809/the-changes-in-adrenal-developmental-programming-and-homeostasis-in-offspring-induced-by-glucocorticoids-exposure-during-pregnancy
#15
REVIEW
Yawen Chen, Hui Wang
Clinically, synthetic glucocorticoids are often used to treat maternal and fetal related diseases, such as preterm birth and autoimmune diseases. Although its clinical efficacy is positive, it will expose the fetus to exogenous glucocorticoids. Adverse environments during pregnancy (e.g., exogenous glucocorticoids exposure, malnutrition, infection, hypoxia, and stress) can lead to fetal overexposure to endogenous maternal glucocorticoids. Basal glucocorticoids levels in utero are crucial in determining fetal tissue maturation and its postnatal fate...
2024: Vitamins and Hormones
https://read.qxmd.com/read/38405745/notum-mediated-wnt-silencing-drives-extravillous-trophoblast-cell-lineage-development
#16
Vinay Shukla, Ayelen Moreno-Irusta, Kaela M Varberg, Marija Kuna, Khursheed Iqbal, Anna M Galligos, John D Aplin, Ruhul H Choudhury, Hiroaki Okae, Takahiro Arima, Michael J Soares
UNLABELLED: Trophoblast stem ( TS ) cells have the unique capacity to differentiate into specialized cell types, including extravillous trophoblast ( EVT ) cells. EVT cells invade into and transform the uterus where they act to remodel the vasculature facilitating the redirection of maternal nutrients to the developing fetus. Disruptions in EVT cell development and function are at the core of pregnancy-related disease. WNT-activated signal transduction is a conserved regulator of morphogenesis of many organ systems, including the placenta...
February 14, 2024: bioRxiv
https://read.qxmd.com/read/38396719/overexpression-of-human-sflt1-in-the-spongiotrophoblast-is-sufficient-to-induce-placental-dysfunction-and-fetal-growth-restriction-in-transgenic-mice
#17
JOURNAL ARTICLE
Rebekka Vogtmann, Alina Riedel, Ivanka Sassmannshausen, Sarah Langer, Elisabeth Kühnel-Terjung, Rainer Kimmig, Hubert Schorle, Elke Winterhager, Alexandra Gellhaus
Preeclampsia (PE) is characterized by maternal hypertension and placental dysfunction, often leading to fetal growth restriction (FGR). It is associated with an overexpression of the anti-angiogenic sFLT1 protein, which originates from the placenta and serves as a clinical biomarker to predict PE. To analyze the impact of sFLT1 on placental function and fetal growth, we generated transgenic mice with placenta-specific human sFLT1 (hsFLT1) overexpression. Immunohistochemical, morphometrical, and molecular analyses of the placentas on 14...
February 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38381050/in-vivo-mitochondria-targeted-protection-against-uterine-artery-vascular-dysfunction-and-remodelling-in-rodent-hypoxic-pregnancy
#18
JOURNAL ARTICLE
Zhongchao Wang, Emily J Camm, Anna Maria Nuzzo, Ana-Mishel Spiroski, Katie L Skeffington, Thomas J Ashmore, Alessandro Rolfo, Tullia Todros, Angela Logan, Jin Ma, Michael P Murphy, Youguo Niu, Dino A Giussani
Gestational hypoxia adversely affects uterine artery function, increasing complications. However, an effective therapy remains unidentified. Here, we show in rodent uterine arteries that hypoxic pregnancy promotes hypertrophic remodelling, increases constrictor reactivity via protein kinase C signalling, and triggers compensatory dilatation via nitric oxide-dependent mechanisms and stimulation of large conductance Ca2+ -activated K+ -channels. Maternal in vivo oral treatment with the mitochondria-targeted antioxidant MitoQ in hypoxic pregnancy normalises uterine artery reactivity and prevents vascular remodelling...
February 21, 2024: Journal of Physiology
https://read.qxmd.com/read/38365664/fetal-hemodynamic-changes-and-mitochondrial-dysfunction-in-myocardium-and-brain-tissues-in-response-to-anemia-a-lesson-from-hemoglobin-bart-s-disease
#19
JOURNAL ARTICLE
Suchaya Luewan, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C Chattipakorn, Theera Tongsong
OBJECTIVE: Whether or not the effects of anemia in the early phase, while the fetuses attempts to increase cardiac output to meet oxygen requirement in peripheral organs, is detrimental to the fetal developing vital organs is little-known. The objective of this is to compare prenatal cardiovascular changes and post-abortal cellular damages in the myocardium as a pumping organ and the brain as a perfused organ between anemic fetuses (using fetal Hb Bart's disease as a study model) in pre-hydropic phase and non-anemic fetuses...
February 16, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38355457/large-scale-analysis-of-interobserver-agreement-and-reliability-in-cardiotocography-interpretation-during-labor-using-an-online-tool
#20
JOURNAL ARTICLE
Imane Ben M'Barek, Badr Ben M'Barek, Grégoire Jauvion, Emilia Holmström, Antoine Agman, Jade Merrer, Pierre-François Ceccaldi
BACKGROUND: While the effectiveness of cardiotocography in reducing neonatal morbidity is still debated, it remains the primary method for assessing fetal well-being during labor. Evaluating how accurately professionals interpret cardiotocography signals is essential for its effective use. The objective was to evaluate the accuracy of fetal hypoxia prediction by practitioners through the interpretation of cardiotocography signals and clinical variables during labor. MATERIAL AND METHODS: We conducted a cross-sectional online survey, involving 120 obstetric healthcare providers from several countries...
February 14, 2024: BMC Pregnancy and Childbirth
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