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Age-dependent changes in mitral valve

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https://www.readbyqxmd.com/read/27875721/percutaneous-mitral-valve-repair-the-last-chance-for-symptoms-improvement-in-advanced-refractory-chronic-heart-failure
#1
Alessandra Berardini, Elena Biagini, Francesco Saia, Davide Stolfo, Mario Previtali, Francesco Grigioni, Bruno Pinamonti, Gabriele Crimi, Alessandro Salvi, Maurizio Ferrario, Antonio De Luca, Fabrizio Gazzoli, Maria Letizia Bacchi Reggiani, Claudia Raineri, Gianfranco Sinagra, Claudio Rapezzi
BACKGROUND: The role of percutaneous mitral valve repair (PMVR) in patients with end-stage heart failure (HF) and functional mitral regurgitation (FMR) is unclear. METHODS: Seventy-five consecutive patients with FMR grade≥3+ and severe HF symptoms despite optimal medical therapy and resynchronization therapy underwent PMVR with the MitraClip system (Abbott, Abbott Park, IL, USA) at 3 centers. Clinical evaluation, echocardiography and pro-BNP measurement were performed at baseline and at 6-month...
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26847283/prosthesis-patient-mismatch-after-mitral-valve-replacement-comparison-of-different-methods-of-effective-orifice-area-calculation
#2
In Jeong Cho, Geu Ru Hong, Seung Hyun Lee, Sak Lee, Byung Chul Chang, Chi Young Shim, Hyuk Jae Chang, Jong Won Ha, Namsik Chung
PURPOSE: The incidence of prosthesis-patient mismatch (PPM) after mitral valve replacement (MVR) has been reported to vary. The purpose of the current study was to investigate incidence of PPM according to the different methods of calculating effective orifice area (EOA), including the continuity equation (CE), pressure half time (PHT) method and use of reference EOA, and to compare these with various echocardiographic variables. MATERIALS AND METHODS: We retrospectively reviewed 166 individuals who received isolated MVR due to rheumatic mitral stenosis and had postoperative echocardiography performed between 12 and 60 months after MVR...
March 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/26743926/update-on-percutaneous-mitral-commissurotomy
#3
REVIEW
Maria Carmo P Nunes, Bruno Ramos Nascimento, Lucas Lodi-Junqueira, Timothy C Tan, Guilherme Rafael Sant'Anna Athayde, Judy Hung
Percutaneous mitral commissurotomy (PMC) is the first-line therapy for managing rheumatic mitral stenosis. Over the past two decades, the indications of the procedure have expanded to include patients with unfavourable valve anatomy as a consequence of epidemiological changes in patient population. The procedure is increasingly being performed in patients with increased age, more deformed valves and associated comorbidities. Echocardiography plays a crucial role in patient selection and to guide a more efficient procedure...
April 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/26621921/single-centre-experience-of-mitral-valve-surgery-via-right-lateral-mini-thoracotomy-in-octogenarians
#4
Jan-Philipp Minol, Payam Akhyari, Udo Boeken, Hiroyuki Kamiya, Tobias Weinreich, Stephan Sixt, Hildegard Gramsch-Zabel, Artur Lichtenberg
OBJECTIVES: According to demographic changes in the industrialized world, the average age of patients referred to cardiac surgery is increasing. These patients typically display numerous comorbidities, associated with increased perioperative risk. Therefore, the indication for a catheter-based therapy is progressively extended, including interventions on the mitral valve (MV). In this context, we evaluated a contemporary series of octogenarians undergoing minimally invasive MV surgery at our institution using right lateral minithoracotomy to elucidate the preoperative risk profile and the postoperative course in this particular cohort...
March 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/26527432/dynamic-heterogeneity-of-the-heart-valve-interstitial-cell-population-in-mitral-valve-health-and-disease
#5
Tori E Horne, Matthew VandeKopple, Kimberly Sauls, Sara N Koenig, Lindsey J Anstine, Vidu Garg, Russell A Norris, Joy Lincoln
The heart valve interstitial cell (VIC) population is dynamic and thought to mediate lay down and maintenance of the tri-laminar extracellular matrix (ECM) structure within the developing and mature valve throughout life. Disturbances in the contribution and distribution of valve ECM components are detrimental to biomechanical function and associated with disease. This pathological process is associated with activation of resident VICs that in the absence of disease reside as quiescent cells. While these paradigms have been long standing, characterization of this abundant and ever-changing valve cell population is incomplete...
September 2015: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/26216371/the-effects-of-right-ventricular-apical-pacing-with-transvenous-pacemaker-and-implantable-cardioverter-defibrillator-on-mitral-and-tricuspid-regurgitation
#6
Zaher Fanari, Sumaya Hammami, Muhammad Baraa Hammami, Safa Hammami, Mossaab Shuraih
BACKGROUND: The incidence of new or worsening tricuspid regurgitation (TR) or mitral regurgitation (MR) after permanent pacemaker (PPM) or implantable cardioverter defibrillator (ICD) lead placement has not been well investigated. We studied the effect of transvenous leads implantation and right ventricular (RV) pacing on tricuspid and mitral valve regurgitations. METHODS: We reviewed the charts of all patients undergoing PPM or ICD lead placement in our electrophysiology laboratory from December 2001 to December 2006...
September 2015: Journal of Electrocardiology
https://www.readbyqxmd.com/read/25971123/-features-of-structural-and-functional-changes-of-the-myocardium-in-patients-with-chronic-viral-hepatitis
#7
E V Radaeva, A V Govorin, M V Chistyakova
OBJECTIVE: Our aim was to evaluate the characteristics of structural and functional changes of the heart in patients with chronic viral hepatitis. METHODS: The study included 123 patients - 17 patients with aviraemnia after antiviral therapy (group 1), 38 patients with laboratory inactive hepatitis (group 2), 68 patients with biochemical active hepatitis (group 3). All patients had standard echocardiography, Doppler sonography and tissue Doppler echocardiography...
2014: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/25345092/mucopolysaccharidosis-type-ii-hunter-s-syndrome
#8
REVIEW
Anna Tylki-Szymańska
Hunter syndrome is caused by deficiency of the lysososmal enzyme iduronate-2-sulphatase that cleaves O-linked sulphate moieties from dermatan sulphate and heparan sulphate and leads to accumulation of GAGs. The disease is a X-linked condition affecting males and rarely females, clinically divided into severe (2/3) and attenuated types. Children with severe form, diagnosed at 12-36 months, have coarse facial feature, short stature, joint stiffness, short neck, broad chest, large head circumference, watery diarrhea, skeletal changes, progressive and profound mental retardation, retinal degeneration' hearing loss, cardiomyopathy, valvular involvement, with progressive thickening and stiffening of the valve leaflets leading to mitral and aortic regurgitation and stenosis ...
September 2014: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/25152379/measurement-of-regional-pulse-wave-velocity-using-spatial-compound-imaging-of-the-common-carotid-artery-in-vivo
#9
Ryo Nagaoka, Genta Masuno, Kazuto Kobayashi, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo
Pulse-wave velocity (PWV) is an important index for diagnosing cardiovascular diseases. The pulse wave is volumetric change induced by heartbeat or inflowing blood, and significantly depends on the propagating path and stiffness of the artery. In this study, PWV of the propagating wave was visualized using spatial compound imaging with high temporal resolution. The frame rate was 1000 Hz, or a time interval of 1 ms. Subjects were four young healthy males and one young healthy female (n=5, age: 23.8±1.17 years old), and the measurement area was the right common carotid artery...
January 2015: Ultrasonics
https://www.readbyqxmd.com/read/25022429/global-endocardial-area-change-rate-for-the-assessment-of-left-ventricular-relaxation-and-filling-pressure-using-3-dimensional-speckle-tracking-study
#10
Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Tatsuya Miyoshi, Junichi Imanishi, Yoshiki Motoji, Yasuhide Mochizuki, Yuko Fukuda, Toshiro Shinke, Ken-ichi Hirata
Early diastolic mitral inflow and annulus velocities ratio (E/e') is the parameter used to estimate left ventricular (LV) filling pressure, but their use for patients with reduced ejection fraction (EF) (<50 %) is controversial. LV endocardial area change rate with 3-dimensional (3-D) speckle-tracking can be used to evaluate the entire LV diastolic function, we tested the hypothesis that the early diastolic area change rate (E-ACR) represents LV relaxation, and E and E-ACR ratio (E/E-ACR) can accurately predict LV filling pressure in patients with reduced and preserved EF (≥50 %)...
December 2014: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/24985995/-operation-of-ebstein-anomaly-in-adulthood-our-experience
#11
Jana Popelová, Roman Gebauer, Petr Pavel, Stěpán Cerný, Pavel Jehlička, Petr Plášil, Ivo Skalsky
INTRODUCTION: The outcome of the operation of the Ebstein anomaly in adulthood depends on the experience of the surgical team. METHODS AND RESULTS: We operated 38 adult patients with Ebstein anomaly at the age of 34.8 ± 12.7 (19-63) years at the Department of Cardiac Surgery, Hospital Na Homolce, Prague, in the period of 2005-2013. The majority of patients (71 %) had Ebstein anomaly type C or D. The 30-days postoperative mortality was 5.2 %. In the long-term follow-up 2 other patients died...
April 2014: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/24954287/slope-in-preload-recruitable-stroke-work-relationship-predicts-survival-after-left-ventriculoplasty-and-mitral-repair-in-patients-with-idiopathic-cardiomyopathy
#12
Yasushige Shingu, Suguru Kubota, Satoru Wakasa, Tomonori Ooka, Hiroki Kato, Tsuyoshi Tachibana, Yoshiro Matsui
BACKGROUND: Left ventriculoplasty (LVP) and mitral valve plasty (MVP) are sometimes effective for patients with idiopathic dilated cardiomyopathy (DCM) who are not eligible for heart transplantation. Strict patient selection is warranted for these controversial procedures. METHODS AND RESULTS: The subjects were 18 patients with idiopathic DCM and mitral regurgitation who had not been indicated for heart transplantation due to either older age or patient refusal, and who underwent LVP and MVP...
February 2015: Journal of Cardiology
https://www.readbyqxmd.com/read/24610511/collateral-dependent-ischemic-mitral-regurgitation
#13
Jean Marc Weinstein, Gizela Kidman, Reuben Ilia
There is much debate on the pathogenesis of ischemic mitral regurgitation (MR), usually related to global or regional left ventricular dysfunction or remodeling secondary to chronic ischemic changes, altering the tethering and closing forces on the mitral apparatus. There is a paucity of literature describing MR in the setting of acute ischemia. We describe a case in which the MR was dynamic and directly related to changes in coronary collateral flow.
March 2014: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/24445792/-mitral-valve-repair-versus-mitral-valve-replacement
#14
J F Onnasch, F Schneider, M Mierzwa, F W Mohr
Over the past 40 years mitral valve surgery has changed dramatically. After initial enthusiasm with the introduction of valve prostheses in the 1960s, a renewed interest in repair techniques began in the 1970s with the introduction of annuloplasty rings. These repair techniques revealed that the integrity of the subvalvular apparatus plays an important role in left ventricular function. When considering the major series comparing early and late results of mitral valve repair versus prosthetic mitral valve replacement, operative mortality rate is lower for patients with mitral valve repair...
December 2001: Zeitschrift Für Kardiologie
https://www.readbyqxmd.com/read/24407535/an-echocardiographic-assessment-of-cardiovascular-hemodynamics-in-patients-with-large-pleural-effusion
#15
COMPARATIVE STUDY
Sundar Chidambaram, Venkatesan Sangareddi, Gnanavelu Ganesan, V E Dhandapani, M S Ravi, K Meenakshi, D Muthukumar, N Swaminathan, G Ravishankar
BACKGROUND: The close relationship between pleural space and pericardial space and the dependence of their pressure kinetics are well known. This study evaluates the effects of increased intra pleural pressure due to pleural effusion on cardiovascular system. METHODS: Forty patients above the age of 12 who had massive unilateral/bilateral pleural effusion due to non-cardiac etiology were included in the study. Therapeutic thoracocentesis was done for massive pleural effusion...
December 2013: Indian Heart Journal
https://www.readbyqxmd.com/read/24100095/mitral-procedure-selection-in-patients-on-dialysis-does-mitral-repair-influence-outcomes
#16
Christina M Vassileva, J Matthew Brennan, James S Gammie, Shubin Sheng, Theresa Boley, Paramita Saha-Chaudhuri, Stephen Hazelrigg
OBJECTIVE: To examine the likelihood of mitral valve repair among dialysis patients and the influence of mitral procedure selection on surgical outcomes in this cohort. METHODS: Among patients undergoing isolated primary mitral valve surgery in the Society of Thoracic Surgeons Adult Cardiac Surgery Database (2002-2010), we used logistic regression models to evaluate the following: (1) the likelihood of attempted and successful mitral repair among dialysis patients (2008-2010), and (2) the impact of mitral procedural selection on surgical mortality and composite mortality/major morbidity experienced by dialysis patients (2002-2010)...
July 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/23703332/rheumatic-fever-rheumatic-heart-disease-the-last-50-years
#17
REVIEW
R Krishna Kumar, R Tandon
Rheumatic fever (RF) and rheumatic heart disease (RHD) continue to be a major health hazard in most developing countries as well as sporadically in developed economies. Despite reservations about the utility, echocardiographic and Doppler (E&D) studies have identified a massive burden of RHD suggesting the inadequacy of the Jones' criteria updated by the American Heart Association in 1992. Subclinical carditis has been recognized by E&D in patients with acute RF without clinical carditis as well as by follow up of RHD patients presenting as isolated chorea or those without clinical evidence of carditis...
April 2013: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/23660866/the-impairment-of-the-parasympathetic-modulation-is-involved-in-the-age-related-change-in-mitral-e-a-ratio
#18
COMPARATIVE STUDY
Ayumi Nakabo, Akiko Goda, Mitsuru Masaki, Misato Otsuka, Chikako Yoshida, Akiyo Eguchi, Shinichi Hirotani, Masaaki Lee-Kawabata, Takeshi Tsujino, Tohru Masuyama
The mitral early to late diastolic flow velocity ratio (E/A ratio) is age-dependent. It has been considered that its age dependency reflects the age-related lengthening of left ventricular (LV) relaxation; however, the change in E/A ratio is far larger than that expected from those in LV relaxation. We hypothesized that an age-related reduction of the parasympathetic activity increases left atrial (LA) contractility, and that this accounts for the age-related change in E/A ratio. (1) Exercise stress test was performed in 61 normal subjects (age range, 8-80 years, mean, 40 years) to assess heart rate (HR) recovery because slowed HR recovery indicates lowered parasympathetic activity...
May 2014: Heart and Vessels
https://www.readbyqxmd.com/read/23503382/-the-mitral-valve-dysplasia-in-adults-the-choice-of-surgical-tactics
#19
COMPARATIVE STUDY
A S Dzemeshkevich, V V Raskin, M S Malikova, Iu V Frolova, S V Korolev, R S Akchurin, S L Dzemeshkevich
Early and long-term results of hereditary mitral valve dysplasia surgical treatment were obtained in 203 patients. All patients were divided in 2 groups: 73 (36%) patients after valve-preserving operations and 130 patients after universal chorda-preserving valve prosthetics. The choice of treatment modality depended on the type of anatomical changes and overall surgical volume. Hospital lethality rate was 2.46%. Surgery led to satisfactory functional results, thus, 83.3% of the operated patients have I-II NYHA functional class...
2013: Khirurgiia
https://www.readbyqxmd.com/read/23487435/right-ventricular-systolic-function-in-organic-mitral-regurgitation-impact-of-biventricular-impairment
#20
Thierry Le Tourneau, Guillaume Deswarte, Nicolas Lamblin, Claude Foucher-Hossein, Georges Fayad, Marjorie Richardson, Anne-Sophie Polge, Claire Vannesson, Yan Topilsky, Francis Juthier, Jean-Noel Trochu, Maurice Enriquez-Sarano, Christophe Bauters
BACKGROUND: To assess the prevalence, determinants, and prognosis value of right ventricular (RV) ejection fraction (EF) impairment in organic mitral regurgitation. METHODS AND RESULTS: Two hundred eight patients (62±12 years, 138 males) with chronic organic mitral regurgitation referred to surgery underwent an echocardiography and biventricular radionuclide angiography with regional function assessment. Mean RV EF was 40.4±10.2%, ranging from 10% to 65%. RV EF was severely impaired (≤35%) in 63 patients (30%), and biventricular impairment (left ventricular EF<60% and RV EF≤35%) was found in 34 patients (16%)...
April 16, 2013: Circulation
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