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Flow mediated dilation

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https://www.readbyqxmd.com/read/29148423/non-invasive-vascular-biomarkers-in-patients-with-beh%C3%A3-et-s-disease-review-of-the-data-and-future-perspectives
#1
REVIEW
Athanase D Protogerou, Efthimia G Nasothimiou, Petros P Sfikakis, Athanasios G Tzioufas
Vascular inflammation in small to large veins and arteries contributes substantially to mortality above that of the general population in Behçet's disease. Recent data verified also the presence of accelerated classical subclinical arterial damage (atheromatosis, arteriosclerosis, arterial hypertrophy) even in patients free of overt vascular complications, and may be complementary to that of vasculitis. Early detection of such vascular damage might provide helpful pathophysiological insight and potentially even guide treatment management...
October 6, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29140431/microvascular-adaptations-to-exercise-protective-effect-of-pgc-1-alpha
#2
Andrew O Kadlec, Chad Barnes, Matthew J Durand, David D Gutterman
BACKGROUND: Sedentary behavior and obesity are major risk factors for cardiovascular disease. Regular physical activity has independent protective effects on the cardiovascular system, but the mechanisms responsible remain elusive. Recent studies suggest that the protein peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) participates in the response to exercise training. We hypothesized that the arterioles of athletes maintain dilation to flow despite combined inhibition of multiple vasodilators, but loss of PGC-1α renders these vessels susceptible to inhibition of a single vasodilator pathway...
November 11, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29139092/effects-of-allopurinol-on-endothelial-function-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#3
REVIEW
Arrigo F G Cicero, Matteo Pirro, Gerald F Watts, Dimitri P Mikhailidis, Maciej Banach, Amirhossein Sahebkar
INTRODUCTION: Uric acid (UA), the final product of purine catabolism, may be associated with an increased risk of cardiovascular disease. AIM: The aim of this meta-analysis of randomized placebo-controlled trials was to evaluate whether lowering serum UA (SUA) levels with allopurinol is associated with improved flow-mediated dilation (FMD), a validated marker of early vascular damage. METHODS: A literature search was carried out from inception until 20 June 2017...
November 14, 2017: Drugs
https://www.readbyqxmd.com/read/29132034/impact-of-flow-mediated-dilatation-and-coronary-calcification-in-providing-complementary-information-on-the-severity-of-coronary-artery-disease
#4
Kentaro Arakawa, Mutsuki Ohno, Mutsuo Horii, Tomoaki Ishigami, Kazuo Kimura, Kouichi Tamura
BACKGROUND AND AIMS: Endothelial dysfunction and coronary artery calcification (CAC) may represent two distinct and separate processes in the development of coronary atherosclerosis. However, the interaction between these factors in determining the development of coronary artery disease (CAD) is uncertain. METHODS: Brachial artery flow-mediated dilatation (FMD) was measured by high-resolution ultrasound before coronary angiography, in 156 patients undergoing coronary CT angiography on suspicion of CAD (M/F 100/56, age 67 ± 11yrs)...
November 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29126987/endothelial-and-kidney-function-in-women-with-a-history-of-preeclampsia-and-healthy-parous-controls-a-case-control-study
#5
Veronica A Lopes van Balen, Julia J Spaan, Tom Cornelis, Wieteke M Heidema, Ralph R Scholten, Marc E A Spaanderman
INTRODUCTION: Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum endothelial dysfunction often persists in these women. We postulate that in women with a history of PE reduced endothelial dependent vasodilation coincides with attenuated kidney function, as both reflect endothelial dysfunction. METHODS: We assessed endothelial and kidney function in women with a history of PE (n=79) and uncomplicated pregnancies (n=49) at least 4years postpartum...
November 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29117072/workplace-strategies-to-prevent-sitting-induced-endothelial-dysfunction
#6
Nicholas T Kruse, William E Hughes, Roberto M Benzo, Lucas J Carr, Darren P Casey
Prolonged sitting induces endothelial dysfunction in healthy young adults which has been demonstrated to be offset by intermittent fidgeting and standing. No information exists on the impact of sitting and endothelial dysfunction in sedentary middle-aged adults, and whether common workplace counter-interventions (i.e. desk-standing/desk-pedaling) mitigate sitting-induced endothelial dysfunction. PURPOSE: The objective of this study was to examine whether breaking up prolonged sitting with intermittent standing or under-desk pedaling prevents sitting-induced popliteal artery endothelial dysfunction in middle-aged sedentary, overweight/obese office workers...
November 7, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29110750/aortic-elasticity-and-carotid-intima-media-thickness-in-children-with-mitral-valve-prolapse
#7
Elif Erolu, Figen Akalın, Nilüfer Çetiner, Berna Şaylan Çevik
Aim We aimed to study the dimensions, systolic and diastolic functions of the left ventricle; dimensions and elasticity of the aorta; and carotid intima-media thickness and flow-mediated dilatation of the brachial artery in mitral valve prolapse. METHODS: The study group consisted of 43 patients (mean age=13.3±3.9) and 42 healthy children (mean age=12.9±3.4). Left ventricular end-diastolic, end-systolic, left atrial diameters, interventricular septum, and left ventricular posterior wall thickness were measured...
November 7, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29101171/high-intensity-interval-exercise-attenuates-but-does-not-eliminate-endothelial-dysfunction-after-a-fast-food-meal
#8
Wesley J Tucker, Brandon J Sawyer, Catherine L Jarrett, Dharini M Bhammar, Justin R Ryder, Siddhartha S Angadi, Glenn A Gaesser
We investigated whether two different bouts of high-intensity interval exercise (HIIE) could attenuate postprandial endothelial dysfunction. Thirteen young (27 ± 1 yr), non-exercise-trained men underwent 3 randomized conditions: (1) HIIE 4x4: four 4-min intervals at 85-95% of maximum heart rate (HRmax) separated by 3 min active recovery, (2) HIIE 16x1: 16 1-min intervals at 85%-95% of HRmax separated by 1 min active recovery, and (3) sedentary control. HIIE was performed in the afternoon, ~18 h prior to the morning fast-food meal (1250 kcal, 63g fat)...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29099231/effects-of-high-intensity-intermittent-training-on-vascular-function-in-obese-preadolescent-boys
#9
Napasakorn Chuensiri, Daroonwan Suksom, Hirofumi Tanaka
BACKGROUND: High-intensity intermittent training (HIIT) may serve as an effective alternative to traditional endurance training, since HIIT has been shown to induce greater improvements in aerobic fitness and health-related markers in adult populations. Our objective was to determine whether HIIT and supramaximal high-intensity intermittent training (supra-HIIT) would improve vascular structure and function in obese preadolescent boys. METHODS: Before the baseline testing, 48 obese preadolescent boys, aged 8-12 years, were randomly assigned into control (CON; n = 16), HIIT (8 × 2 minutes at 90% peak power output, n = 16), and supra-HIIT (8 × 20 seconds at 170% peak power output, n = 16) groups...
November 3, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/29098086/effect-of-exercise-intervention-on-flow-mediated-dilation-in-overweight-and-obese-adults-meta-analysis
#10
REVIEW
Younsun Son, Kyungun Kim, Soeun Jeon, Minsoo Kang, Sukho Lee, Yoonjung Park
The objective of this meta-analysis is to summarize the effect of exercise intervention on flow-mediated dilatation (FMD) in overweight and obese adults. We searched four electronic databases (PubMed/Medline, Scopus, and CINAHL) through June 2016 for relevant studies pertaining to the effectiveness of exercise intervention on FMD. Seventeen of the 91 studies identified met the inclusion criteria. Comprehensive Meta-Analysis software (version 3) was used to compute the standardized mean difference effect size (ES) and 95% CI using a random effects model...
2017: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/29095713/bicuspid-aortic-valve-associated-aortopathy-update-on-biomarkers
#11
Ashna K Maredia, Steven C Greenway, Subodh Verma, Paul W M Fedak
PURPOSE OF REVIEW: Bicuspid aortic valve (BAV)-associated aortopathy is common and its progression for individual patients is difficult to predict. The present review aims to identify recent developments using biomarkers for the determination of risk and progression of disease in patients with BAV aortopathy. RECENT FINDINGS: Novel rare genetic variants and epigenetic methylation signatures affecting non-cytosine phosphate guanine (non-CpG) and CpG sites, nicotinamide phosphoribosyltransferase and Sod expression may lead to improved prediction of the aortopathy phenotype...
October 31, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29095241/effects-of-cerebral-blood-flow-and-vessel-conditions-on-speech-recognition-in-patients-with-postlingual-adult-cochlear-implant-predictable-factors-for-the-efficacy-of-cochlear-implant
#12
Takashi Ishino, Mahmoud Ali Ragaee, Tatsuya Maruhashi, Masato Kajikawa, Yukihito Higashi, Toru Sonoyama, Sachio Takeno, Katsuhiro Hirakawa
OBJECTIVES: Cochlear implantation (CI) has been the most successful procedure for restoring hearing in a patient with severe and profound hearing loss. However, possibly owing to the variable brain functions of each patient, its performance and the associated patient satisfaction are widely variable. The authors hypothesize that peripheral and cerebral circulation can be assessed by noninvasive and globally available methods, yielding superior presurgical predictive factors of the performance of CI in adult patients with postlingual hearing loss who are scheduled to undergo CI...
October 31, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29093276/alpha-2-macroglobulin-as-a-promising-biological-marker-of-endothelial-function
#13
Ryo Shimomura, Tomohisa Nezu, Naohisa Hosomi, Shiro Aoki, Takamichi Sugimoto, Naoto Kinoshita, Mutsuko Araki, Tetsuya Takahashi, Hirofumi Maruyama, Masayasu Matsumoto
AIMS: Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors. METHODS: Patients with a history of stroke or any established cardiovascular risk factors were enrolled in this study (n=102; 69 men, 70...
November 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29083061/the-impact-of-menstrual-phase-on-brachial-artery-flow-mediated-dilation-during-handgrip-exercise-in-healthy-premenopausal-women
#14
Katrina A D'Urzo, Trevor J King, Jennifer S Williams, Morgan D Silvester, Kyra E Pyke
Flow-mediated dilation (FMD) in response to a sustained shear stress stimulus (e.g. via handgrip exercise; HGEX) is emerging as a useful tool for assessing endothelial function; however, the impact of menstrual phase on HGEX-FMD is unknown. The purpose of this study was to determine whether HGEX-FMD fluctuates with cyclical changes in estrogen levels over two discrete phases (low and high estrogen) of the menstrual cycle. Brachial artery (BA) diameter and blood velocity were assessed with 2D and Doppler ultrasound, respectively...
October 30, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29080864/endothelial-progenitor-cell-biology-and-vascular-recovery-following-transradial-cardiac-catheterization
#15
Andrew Mitchell, Takeshi Fujisawa, Nicholas L Mills, Mairi Brittan, David E Newby, Nicholas L M Cruden
BACKGROUND: Transradial catheterization is associated with radial artery injury and vasomotor dysfunction and represents an accessible model of acute vascular injury in humans. We characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair. METHODS AND RESULTS: In 50 patients (aged 64±10 years, 70% male) undergoing transradial cardiac catheterization, radial artery injury was assessed by optical coherence tomography and examination of explanted vascular sheaths...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29069316/retinal-microvascular-dysfunction-in-heart-failure
#16
Matthias P Nägele, Jens Barthelmes, Valeria Ludovici, Silviya Cantatore, Arnold von Eckardstein, Frank Enseleit, Thomas F Lüscher, Frank Ruschitzka, Isabella Sudano, Andreas J Flammer
Aims: Retinal vessel analysis (RVA) represents a novel, non-invasive, and reliable method to study the microcirculation in the eye. The goal of this study was to assess the extent of retinal microvascular dysfunction in patients with chronic heart failure (CHF) compared to controls and established measures of vascular function. Methods and results: In this prospective, single-centre, observational study, 74 patients with compensated CHF (mean age 63.5 ± 11...
October 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29069202/association-of-inflammation-and-endothelial-dysfunction-with-coronary-microvascular-resistance-in-patients-with-cardiac-syndrome-x
#17
Ming Long, Zhibin Huang, Xiaodong Zhuang, Zena Huang, Yue Guo, Xinxue Liao, Chufan Luo
BACKGROUND: Although a proportion of CSX patients have impaired brachial artery flow-mediated dilatation (FMD) in response to hyperemia, suggesting that endothelial dysfunction in these patients may be systemic and not just confined to the coronary circulation; the underlying mechanisms triggering endothelial dysfunction in these patients are still incompletely understood. OBJECTIVES: To assess the association of the index of Microcirculatory Resistance (IMR) with endothelial dysfunction and inflammation in patients with CSX...
October 19, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29064536/flow-mediated-dilatation-to-relieve-puncture-induced-radial-artery-spasm-a-pilot-study
#18
Lianghong Ying, Ke Xu, Xiaoxuan Gong, Xiaoyan Liu, Yuansheng Fan, Haiping Zhao, Fei Wang, Mohammad Reeaze Khurwolah, Chunjian Li
BACKGROUND: Puncture-induced radial artery spasm (RAS) may extend the duration of coronary angiography (CAG) or cause transradial access failure. Flow-mediated dilatation (FMD), a widely-used noninvasive approach for assessing endothelial function, was reported to remove the entrapped radial sheath after percutaneous coronary intervention. Herein, the efficacy and safety of FMD in treating puncture-induced RAS before transradial CAG was investigated. METHODS: Ninety patients with puncture-induced RAS were randomized in a 1:1:1 ratio into three groups: FMD group was immediately treated with blockage of brachial artery blood for 5 min using a sphygmomanometric cuff and then rapid relief; NTG group was administered with 0...
October 24, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29064046/hla-infections-and-inflammation-in-early-stages-of-atherosclerosis-in-children-with-type-1-diabetes
#19
Michal Odermarsky, Erkki Pesonen, Timo Sorsa, Åke Lernmark, Pirkko J Pussinen, Petru Liuba
AIMS: This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D). METHODS: Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients...
October 24, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29063462/the-role-of-microalbuminuria-as-a-predictor-of-subclinical-cardiovascular-events-in-rheumatoid-arthritis-patients-and-its-relation-to-disease-activity
#20
D W Nada, S El Morsy, M H Abu-Zaid, M A Aboelhawa, Mohammad A Zakaria, E A El Sheikh, R A Gaber
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers...
October 23, 2017: Clinical Rheumatology
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