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Flow mediated dilation

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https://www.readbyqxmd.com/read/28213406/mitochondria-regulated-formation-of-endothelial-extracellular-vesicles-shifts-the-mediator-of-flow-induced-vasodilation
#1
Julie K Freed, Matthew J Durand, Brian Robert Hoffmann, John C Densmore, Andrew S Greene, David D Gutterman
In order to examine the effect of endothelial-derived extracellular vesicles (eEVs) on the mechanism of flow-induced dilation (FID) composition, formation, and functional effects on the mechanism of FID were examined from two different eEV subtypes, one produced from ceramide, the other from plasminogen-activator inhibitor 1 (PAI-1). Using videomicroscopy, internal diameter changes in response to increases in flow were measured in human adipose resistance arteries acutely exposed (30min) to eEVs derived from cultured endothelial cells exposed to ceramide or PAI-1...
February 17, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28209742/cardiorespiratory-fitness-modulates-the-acute-flow-mediated-dilation-response-following-high-intensity-but-not-moderate-intensity-exercise-in-elderly-men
#2
Tom G Bailey, Maria Perissiou, Mark Windsor, Fraser D Russell, Jonathan Golledge, Daniel J Green, Christopher D Askew
Impaired endothelial function is observed with ageing and with low cardiorespiratory fitness (VO2peak) whilst improvements in both are suggested to be reliant on higher-intensity exercise in the elderly. This may be due to the flow-mediated dilation (FMD) response to acute exercise of varying intensity. We examined the hypothesis that exercise-intensity alters the FMD response in healthy elderly adults, and would be modulated by VO2peak Forty-seven elderly men were stratified into lower- (VO2peak = 24.3±2...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28207997/chronically-elevated-bilirubin-protects-from-cardiac-reperfusion-injury-in-the-male-gunn-rat
#3
Bhavisha Bakrania, Eugene F Du Toit, Kevin J Ashton, Karl-Heinz Wagner, John P Headrick, Andrew C Bulmer
AIMS: Bilirubin is associated with reduced risk of cardiovascular disease, as evidenced in conditions of mild hyperbilirubinaemia (Gilbert's Syndrome). Little is known regarding myocardial stress-resistance in hyperbilirubinemic conditions or whether life-long exposure modifies cardiac function, which might contribute to protection from cardiovascular disease. METHODS: Hyperbilirubinemic rats and littermate controls underwent echocardiography at 3, 6 and 12 mo of age, with hearts subsequently assessed for resistance to 30 min of ischaemia...
February 16, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28199074/inflammatory-markers-and-brain-derived-neurotrophic-factor-as-potential-bridges-linking-bipolar-disorder-and-cardiovascular-risk-among-adolescents
#4
Jessica K Hatch, Gustavo Scola, Omodele Olowoyeye, Jordan E Collins, Ana C Andreazza, Alan Moody, Anthony J Levitt, Bradley H Strauss, Krista L Lanctot, Benjamin I Goldstein
OBJECTIVE: Bipolar disorder (BD) is associated with increased rates of cardiovascular disease (CVD). Brain-derived neurotrophic factor (BDNF) and inflammatory markers are leading biomarkers in BD. We examined whether these biomarkers underlie the link between BD and CVD proxies among adolescents with bipolar spectrum disorders. METHODS: Subjects were 60 adolescents, 13-19 years old (40 with BD and 20 healthy controls [HCs]). Semistructured interviews determined diagnoses based on DSM-IV...
February 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28194660/a-novel-apparatus-for-the-multifaceted-evaluation-of-arterial-function-through-transmural-pressure-manipulation
#5
Toshiyuki Yaguchi, Yalin Cong, Kenji Shimo, Takahiro Kurokawa, Shukei Sugita, Kazuaki Nagayama, Hiroshi Masuda, Takeo Matsumoto
A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial artery. Endothelial function was measured via a standard flow-mediated dilation (FMD) protocol. Smooth muscle function was evaluated via a myogenic contraction of the artery following the application of negative pressure to the chamber and was named pressure-mediated contraction (PMC)...
February 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28185531/endothelial-dysfunction-in-normoglycaemic-first-degree-relatives-of-type-2-diabetes-mellitus-complicated-with-hyperuricaemia
#6
Junxia Zhang, Lin Xiang, Bilin Zhang, Yangyang Cheng
OBJECTIVE: To reveal the effect of hyperuricaemia on endothelial function in normoglycaemic first-degree relatives of type 2 diabetes mellitus. METHODS: In all, 40 first-degree relatives of type 2 diabetes mellitus with hyperuricaemia, 40 first-degree relatives of type 2 diabetes mellitus with normouricaemia and 35 healthy subjects without diabetic family history were recruited in this study. Anthropometric parameters as well as blood pressure, blood lipids, fasting blood glucose, fasting insulin, C-reactive protein, tumour necrosis factor-α and interleukin-6 were measured...
March 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28183819/a-chronic-physical-activity-treatment-in-obese-rats-normalizes-the-contributions-of-et-1-and-no-to-insulin-mediated-posterior-cerebral-artery-vasodilation
#7
T Dylan Olver, Matthew W McDonald, Diana Klakotskaia, Rachel A Richardson, Jeffrey L Jasperse, C W James Melling, Todd R Schachtman, Hsiao T Yang, Craig A Emter, M Harold Laughlin
This study tested the hypotheses that obesity-induced decrements in insulin-stimulated cerebrovascular vasodilation would be normalized with acute endothelin-1a receptor antagonism, and treatment with a physical activity intervention restores vasoreactivity to insulin through augmented nitric oxide synthase (NOS)-dependent dilation. Otsuka Long-Evans Tokushima Fatty rats were divided into the following groups; 20-wk old food-controlled (CON-20); 20-wk old free-food access (model of obesity, OB-20); 40-wk old food-controlled (CON-40); 40-wk old free-food access (OB-40); and 40-wk old free-food access+RUN (RUN-40; wheel-running access from 20-40 wk)...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183353/endothelial-injury-in-rheumatoid-arthritis-a-crosstalk-between-dimethylarginines-and-systemic-inflammation
#8
Theodoros Dimitroulas, James Hodson, Aamer Sandoo, Jacqueline Smith, George D Kitas
BACKGROUND: Symmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by high CVD mortality and morbidity. ADMA and SDMA levels are abnormal in RA patients, but their correlation with assessments of endothelial function and structure remains unknown. We aimed to investigate whether SDMA and ADMA are associated with carotid intima media thickness (cIMT) and arterial stiffness as well as non-invasive assessments of in vivo micro- and macrovascular endothelial function in RA patients with high systemic inflammatory load...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28170124/physiologic-adaptation-of-endothelial-function-to-pregnancy-a-systematic-review-and-meta-analysis
#9
REVIEW
Veronica A Lopes van Balen, Tessa A G van Gansewinkel, Sander de Haas, Sander M J van Kuijk, Joris van Drongelen, Chahinda Ghossein-Doha, Marc E A Spaanderman
OBJECTIVES: The purpose of this systematic review and meta-analysis is to establish reference values for flow mediated dilatation (FMD) and baseline brachial artery diameter in pregnancy (BBAD) and, to provide insight in the physiological and pathological course of endothelial adaptation throughout human singleton pregnancies. METHODS: A meta-analysis was performed by a systematic review of current literature on FMD, as a derivative for endothelial function, throughout uncomplicated and complicated pregnancies...
February 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28167186/the-effect-of-bikram-yoga-on-endothelial-function-in-young-and-middle-aged-and-older-adults
#10
Stacy D Hunter, Mandeep S Dhindsa, Emily Cunningham, Takashi Tarumi, Mohammed Alkatan, Nantinee Nualnim, Ahmed Elmenshawy, Hirofumi Tanaka
The purpose of this investigation was to determine if Bikram yoga, a style of heated hatha yoga, would improve endothelial function in young and middle-aged and older, healthy adults. This trial was performed in 36 young (n = 17) and middle-aged and older adults (n = 19) who completed 3 weekly Bikram yoga classes for 8 weeks. Height, body weight and body composition were determined and endothelial function was measured noninvasively using brachial artery flow-mediated dilation (FMD) before and after the intervention...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28164350/correlation-between-flow-mediated-dilatation-of-the-brachial-artery-and-serum-endothelial-biomarkers-in-the-evaluation-of-acute-endothelial-injury-after-cardiopulmonary-bypass
#11
Wei-Jian Wang, Jia-Hao Zhou, Guo-Liang He, Qiao-Lin Wu, Wei Gao, Jie-Hao Sun, Peng-Bo Zhang
OBJECTIVES: The purpose of this study was to investigate the correlation between flow-mediated dilatation of the brachial artery and serum endothelial biomarkers and to discuss the feasibility of sonographic evaluation of acute endothelial injury during cardiopulmonary bypass (CPB) surgery. METHODS: Sonography was applied to determine the percentage of change in the brachial artery size during flow-mediated dilatation. Meanwhile, the plasma concentrations of endothelial-derived biomarkers, such as endothelin 1, nitric oxide, and von Willebrand factor, were measured to monitor the changes in endothelial function...
February 6, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28159811/using-heat-as-a-therapeutic-tool-for-the-aging-vascular-tree
#12
Ryan McGinn, Martin P Poirier, Glen P Kenny
Healthy aging in humans is associated with progressive deterioration of various organ systems, the cardiovascular system being one of the most notable. Young arteries have a pronounced ability to dilate and constrict to mediate changes in blood flow in response to various stimuli (e.g. exposure to a cold or hot environment). With increasing age, complex structural and functional changes to the blood vessels occur which are further exacerbated by common comorbidities including hypertension, diabetes mellitus and hypercholesterolemia...
February 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28155612/the-influence-of-dietary-components-on-early-signs-of-atherosclerosis-in-apparently-healthy-young-adult-males-an-observational-study-of-615-subjects
#13
Girolamo Catapano Minotti, Francesca Cortese, Andrea Corsonello, Giovanni Guadalupi, Antonio Paolo D Arcangelo, Saverio Daniele Palumbo, Rita Naio, Ottovio De Clemente, Andrea Aurelio, Simona Carone, Tiziana Gelsumino, Vincenzo Gemignani, Elisabetta Bianchini, Mariangela Vigotti, Francesco Faita, Luciano Greco, Roberto Primerano, Raffaele Antonelli Incalzi, Marco Matteo Ciccone
BACKGROUND: the literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis. DESIGN: a cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery. METHODS: 615 males (mean age ± SD: 40...
February 1, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28155247/flow-mediated-dilation-assessment-in-the-superficial-femoral-artery-using-a-sustained-shear-stress-stimulus-via-calf-plantar-flexion-exercise
#14
T J King, S M Schmitter, K E Pyke
: The superficial femoral artery (SFA) is susceptible to vascular disease, and a technique to assess flow mediated dilation (FMD) in this vessel in response to a sustained shear stress stimulus could provide important information about endothelial function. PURPOSE: To establish the ability of a newly designed SFA leg exercise-FMD (LEX-FMD) technique to produce sustained elevations in shear rate which stimulate FMD, and to determine the repeat trial stability of the FMD response...
February 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28154165/heritability-of-vascular-structure-and-function-a-parent-child-study
#15
Justin R Ryder, Nathan D Pankratz, Donald R Dengel, James S Pankow, David R Jacobs, Alan R Sinaiko, Vasu Gooty, Julia Steinberger
BACKGROUND: Understanding the heritable contribution of vascular measures, from parent to offspring, may aid in risk stratification and atherosclerosis prevention efforts. We hypothesized that measures of vascular structure and function would be heritable in this cohort of parents and their adolescent offspring. METHODS AND RESULTS: High-resolution ultrasound scans of the brachial and carotid arteries were obtained in parents (n=558) and their offspring (n=369)...
February 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28153942/divergent-endothelial-function-but-similar-platelet-microvesicle-responses-following-eccentric-and-concentric-cycling-at-a-similar-aerobic-power-output
#16
Mark Rakobowchuk, Ophélie Ritter, Eurico Nestor Wilhelm, Laurie Isacco, Malika Bouhaddi, Bruno Degano, Nicolas Tordi, Laurent Mourot
Endothelial function and microvesicle concentration changes after acute bouts of continuous eccentric exercise have not been assessed previously nor compared to concentric exercise at similar aerobic power outputs. This method of training may be useful amongst some clinical populations, but acute responses are not well described. As such, twelve healthy males completed two experimental sessions of either 45 minutes of eccentric or concentric cycling at a matched aerobic power output below the ventilatory threshold...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28148533/inhibition-of-vascular-smooth-muscle-inward-rectifier-k-channels-restores-myogenic-tone-in-mouse-urinary-bladder-arterioles
#17
Nathan R Tykocki, Adrian D Bonev, Thomas Andrew Longden, Thomas J Heppner, Mark T Nelson
Prolonged decreases in urinary bladder blood flow are linked to overactive and underactive bladder pathologies. However, the mechanisms regulating bladder vascular reactivity are largely unknown. To investigate these mechanisms, we examined myogenic and vasoactive properties of mouse bladder feed arterioles (BFAs). Unlike similar-sized arterioles from other vascular beds, BFAs failed to constrict in response to increases in intraluminal pressure (5-80 mmHg). Consistent with this lack of myogenic tone, arteriolar smooth muscle cell membrane potential was hyperpolarized (-72...
February 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28144257/treatment-of-denture-related-stomatitis-improves-endothelial-function-assessed-by-flow-mediated-vascular-dilation
#18
Grzegorz Osmenda, Joanna Maciąg, Grzegorz Wilk, Anna Maciąg, Daniel Nowakowski, Jolanta Loster, Elżbieta Dembowska, Douglas Robertson, Tomasz Guzik, Marta Cześnikiewicz-Guzik
INTRODUCTION: The presence of oral inflammation has recently been linked with the pathogenesis of cardiovascular diseases. While numerous studies have described links between periodontitis and endothelial dysfunction, little is known about the influence of denture-related stomatitis (DRS) on cardiovascular risk. Therefore, the aim of this study was to determine whether the treatment of DRS can lead to improvement of the clinical measures of vascular dysfunction. MATERIAL AND METHODS: The DRS patients were treated with a local oral antifungal agent for 3 weeks...
February 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28141664/free-androgen-index-as-a-determinant-of-arterial-stiffness-in-menopause-a-mediation-analysis
#19
Irene Lambrinoudaki, Georgios A Georgiopoulos, Fani Athanasouli, Elena Armeni, Demetrios Rizos, Areti Augoulea, Sofia Chatzidou, Evangelia Koutli, Nikolaos Makris, Ioannis Kanakakis, Kimon Stamatelopoulos
OBJECTIVE: Associations of endogenous androgens in menopause with blood pressure (BP) and indices of arterial stiffness are reported, but directional relationships are not clear. Structural equation modeling is a contemporary statistical method, which allows assessment of such relationships and improves pathway understanding. METHODS: We recruited 411 consecutive apparently healthy postmenopausal women who underwent noninvasive vascular evaluation. This included pulse wave analysis (aortic pressures and arterial wave reflections [augmentation index]), measurement of aortic stiffness by pulse wave velocity (PWV), stiffness index (SI), and flow-mediated dilatation...
January 30, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28137492/subclinical-atherosclerosis-risk-markers-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#20
REVIEW
Ling-Yun Wang, Ya-Nan Zhu, Juan-Juan Cui, Ke-Qin Yin, Shao-Xia Liu, Yong-Hua Gao
BACKGROUND AND AIMS: Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Identifying early changes of cardiovascular system before the occurrence of fatal clinical event is critical for the management of COPD. We performed a meta-analysis to investigate the associations between COPD and subclinical markers of cardiovascular risk. METHODS: We searched PUBMED, EMBASE for studies published before Aug 1st, 2016, on the association between COPD and carotid intima-media thickness (CIMT), prevalence of carotid plaques, flow-mediated dilation (FMD), pulse-wave velocity (PWV) and augmentation index (AIx)...
February 2017: Respiratory Medicine
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