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https://www.readbyqxmd.com/read/29218692/euro-b-o-s-s-a-european-study-on-chemotherapy-in-bone-sarcoma-patients-aged-over-40-outcome-in-primary-high-grade-osteosarcoma
#1
Stefano Ferrari, Stefan S Bielack, Sigbjørn Smeland, Alessandra Longhi, Gerlinde Egerer, Kirsten Sundby Hall, Davide Donati, Matthias Kevric, Otte Brosjö, Alessandro Comandone, Mathias Werner, Odd Monge, Emanuela Palmerini, Wolfgang E Berdel, Bodil Bjerkehagen, Anna Paioli, Sylvie Lorenzen, Mikael Eriksson, Marco Gambarotti, Per-Ulf Tunn, Nina L Jebsen, Marilena Cesari, Thekla von Kalle, Virginia Ferraresi, Rudolf Schwarz, Rossella Bertulli, Anne-Katrin Kasparek, Giovanni Grignani, Fatime Krasniqi, Benjamin Sorg, Stefanie Hecker-Nolting, Piero Picci, Peter Reichardt
INTRODUCTION: The EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.) was the first prospective international study for patients 41-65 years old with high-grade bone sarcoma treated with an intensive chemotherapy regimen derived from protocols for younger patients with high-grade skeletal osteosarcoma. METHODS: Chemotherapy based on doxorubicin, cisplatin, ifosfamide, and methotrexate was suggested, but patients treated with other regimens at the investigators' choice were also eligible for the study...
December 5, 2017: Tumori
https://www.readbyqxmd.com/read/29217887/renal-complications-of-hematopoietic-stem-cell-transplantation-report-of-a-case-and-review-of-the-literature
#2
E Liquete, S R Williamson, N Janakiraman, K K Venkat
We report the development of minimal change disease superimposed on preexisting chronic kidney disease secondary to chronic calcineurin inhibitor nephrotoxicity in a hematopoietic stem cell transplantation (HSCT) recipient and review the renal complications of HSCT.
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29217759/opposing-roles-of-dendritic-cell-subsets-in-experimental-gn
#3
Sebastian Brähler, Bernd H Zinselmeyer, Saravanan Raju, Maximilian Nitschke, Hani Suleiman, Brian T Saunders, Michael W Johnson, Alexander M C Böhner, Susanne F Viehmann, Derek J Theisen, Nicole M Kretzer, Carlos G Briseño, Konstantin Zaitsev, Olga Ornatsky, Qing Chang, Javier A Carrero, Jeffrey B Kopp, Maxim N Artyomov, Christian Kurts, Kenneth M Murphy, Jeffrey H Miner, Andrey S Shaw
Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and throughout organs, including the kidney, to perform an important sentinel function. However, previous studies of DC function used markers, such as CD11c or CX3CR1, that are not unique to DCs. Here, we evaluated the role of DCs in renal inflammation using a CD11c reporter mouse line and two mouse lines with DC-specific reporters, Zbtb46-GFP and Snx22-GFP. Multiphoton microscopy of kidney sections confirmed that most of the dendritically shaped CD11c+ cells forming a network throughout the renal interstitium expressed macrophage-specific markers...
December 7, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29217164/the-protective-role-of-crocin-in-tartrazine-induced-nephrotoxicity-in-wistar-rats
#4
Mehmet Erman Erdemli, Mehmet Gul, Eyup Altinoz, Emrah Zayman, Zeynep Aksungur, Harika Gozukara Bag
The present study was conducted to investigate the changes in rat kidney tissues after administration of tartrazine (T) and crocine (Cr). The latter was applied for its protective properties. The present study was conducted with the approval of Inonu University, Faculty of Medicine, Experimental Animals Ethics Committee. Forty rats were randomly divided into 4 equal groups (Control, T, Cr, T + Cr). At the end of the experiment, the rats were decapitated. Biochemical and histopathological studies were conducted on excised rat kidney tissues...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29216766/vanillin-mitigates-the-adverse-impact-of-cisplatin-and-methotrexate-on-rat-kidneys
#5
A A Fouad, W N Al-Melhim
The present study investigated the probable protective effect of vanillin (VLN) against kidney injury induced by cisplatin (CSN) and methotrexate (MTX) in rats. The rats received a single injection of either CSN (7.5 mg/kg, i.p.) or MTX (20 mg/kg, i.p.). VLN treatment (150 mg/kg/day, i.p.) was started 1 day before administration of the nephrotoxic agents and continued for 7 days. Both CSN and MTX significantly increased serum creatinine, cystatin C, and neutrophil gelatinase-associated lipocalin and kidney tissue renal malondialdehyde, inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-18, nuclear factor-κB p65, cytosolic cytochrome C, and caspase-3 and significantly decreased renal total antioxidant capacity and Bcl-2/Bax ratio in rats...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29214717/bisphenol-a-is-an-exogenous-toxin-that-promotes-mitochondrial-injury-and-death-in-tubular-cells
#6
Enrique Bosch-Panadero, Sebastian Mas, Esther Civantos, Pedro Abaigar, Vanesa Camarero, Alberto Ruiz-Priego, Alberto Ortiz, Jesus Egido, Emilio González-Parra
BACKGROUND: Uremic toxins that accumulate in chronic kidney disease (CKD) contribute to CKD complications, such as CKD progression. Bisphenol A (BPA) is a ubiquitous environmental toxin, structurally related with p-cresol, that accumulates in CKD. Our aim was to characterize the nephrotoxic potential of BPA. Specifically, we addressed BPA toxicity over energy-demanding proximal tubular cells. METHODS: Cell death and oxidative stress were evaluated by flow cytometry and confocal microscopy in HK-2 human proximal tubular epithelial cells...
December 7, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29214169/reversal-of-proximal-renal-tubular-dysfunction-after-nucleotide-analogue-withdrawal-in-chronic-hepatitis-b
#7
Abhasnee Sobhonslidsuk, Pawin Numthavaj, Jirachaya Wanichanuwat, Areepan Sophonsritsuk, Supanna Petraksa, Alongkorn Pugasub, Paisan Jittorntam, Anucha Kongsomgan, Sittiruk Roytrakul, Bunyong Phakdeekitcharoen
Aims: Proximal renal tubular dysfunction (PRTD) is an infrequent complication after nucleotide analogue therapy. We evaluated the outcomes of PRTD and nephrotoxicity after nucleotide analogue withdrawal in chronic hepatitis B (CHB). Methods: A longitudinal follow-up study was performed in patients with PRTD after nucleotide analogue discontinuation. Serum and urine were collected at baseline and every 3 months for one year. The fractional excretion of phosphate (PO4), uric acid (UA), and potassium and tubular maximal reabsorption rate of PO4 to glomerular filtration rate (TmPO4/GFR) were calculated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29213345/the-management-of-chronic-pulmonary-aspergillosis-the-uk-national-aspergillosis-centre-approach
#8
REVIEW
Firas Maghrabi, David W Denning
Purpose of Review: Chronic pulmonary aspergillosis (CPA) is a serious long-term fungal disease of the lung with a worldwide prevalence. Treatment of CPA is not straightforward given the often-multiple associated co-morbidities, complex clinical picture, drug interactions, toxicities and intolerances. Recent Findings: First line treatment is oral itraconazole or voriconazole. In the event of intolerance or toxicity, patients may be swapped from itraconazole to voriconazole or vice versa...
2017: Current Fungal Infection Reports
https://www.readbyqxmd.com/read/29213265/lactobacillus-plantarum-mys6-ameliorates-fumonisin-b1-induced-hepatorenal-damage-in-broilers
#9
B V Deepthi, Rakesh Somashekaraiah, K Poornachandra Rao, N Deepa, N K Dharanesha, K S Girish, M Y Sreenivasa
Fumonisin B1 (FB1), a mycotoxin produced by Fusarium species is a predominant Group 2B carcinogen occurring in maize and maize-based poultry feeds. It is shown to be nephrotoxic, hepatotoxic, neurotoxic, and immunosuppressing in animals. In this study, we report the ameliorating effects of a probiotic strain, Lactobacillus plantarum MYS6 on FB1-induced toxicity and oxidative damage in broilers. A 6-week dietary experiment consisting of 48 broilers was performed in six treatment groups. Probiotic treatment (109 cells/mL) involved pre-colonization of broilers with L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29211658/letermovir-prophylaxis-for-cytomegalovirus-in-hematopoietic-cell-transplantation
#10
Francisco M Marty, Per Ljungman, Roy F Chemaly, Johan Maertens, Sanjeet S Dadwal, Rafael F Duarte, Shariq Haider, Andrew J Ullmann, Yuta Katayama, Janice Brown, Kathleen M Mullane, Michael Boeckh, Emily A Blumberg, Hermann Einsele, David R Snydman, Yoshinobu Kanda, Mark J DiNubile, Valerie L Teal, Hong Wan, Yoshihiko Murata, Nicholas A Kartsonis, Randi Y Leavitt, Cyrus Badshah
Background Cytomegalovirus (CMV) infection remains a common complication after allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the CMV-terminase complex. Methods In this phase 3, double-blind trial, we randomly assigned CMV-seropositive transplant recipients, 18 years of age or older, in a 2:1 ratio to receive letermovir or placebo, administered orally or intravenously, through week 14 after transplantation; randomization was stratified according to trial site and CMV disease risk...
December 6, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29210830/tenofovir-associated-nephrotoxicity-among-a-us-national-historical-cohort-of-hiv-infected-veterans-risk-modification-by-concomitant-antiretrovirals
#11
Joanne LaFleur, Adam P Bress, Stephen Esker, Kristin Knippenberg, Jacob Crook, Heather Nyman, Roger Bedimo, Pablo Tebas, Lisa Rosenblatt
BACKGROUND: Tenofovir disoproxil fumarate (TDF) has been associated with renal complications. The third agent in TDF-containing antiretroviral regimens may modify that risk. We compared renal adverse outcomes among treatment-naïve HIV-infected patients initiating TDF-containing regimens including efavirenz (EFV) or other agents. SETTING: This population-based historical cohort study used national Veterans Health Administration (VHA) clinical and administrative datasets to identify treatment-naïve HIV-infected veterans initiating antiretroviral therapy (ART) with TDF/emtricitabine (FTC)+EFV, rilpivirine (RPV), elvitegravir/cobicistat (EVG/c), or ritonavir (RTV)-boosted protease inhibitors (PIs) from 2003-2015...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29209836/accuracy-of-cystatin-c-for-the-detection-of-abnormal-renal-function-in-children-undergoing-chemotherapy-for-malignancy-a-systematic-review-using-individual-patient-data
#12
Penny Whiting, Kate Birnie, Jonathan A C Sterne, Catherine Jameson, Rod Skinner, Bob Phillips
PURPOSE: We conducted a systematic review and individual patient data (IPD) meta-analysis to examine the utility of cystatin C for evaluation of glomerular function in children with cancer. METHODS: Eligible studies evaluated the accuracy of cystatin C for detecting poor renal function in children undergoing chemotherapy. Study quality was assessed using QUADAS-2. Authors of four studies shared IPD. We calculated the correlation between log cystatin C and GFR stratified by study and measure of cystatin C...
December 6, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29209721/effect-of-high-cutoff-hemodialysis-vs-conventional-hemodialysis-on-hemodialysis-independence-among-patients-with-myeloma-cast-nephropathy-a-randomized-clinical-trial
#13
Frank Bridoux, Pierre-Louis Carron, Brigitte Pegourie, Eric Alamartine, Karine Augeul-Meunier, Alexandre Karras, Bertrand Joly, Marie-Noëlle Peraldi, Bertrand Arnulf, Cécile Vigneau, Thierry Lamy, Alain Wynckel, Brigitte Kolb, Bruno Royer, Nolwenn Rabot, Lotfi Benboubker, Christian Combe, Arnaud Jaccard, Bruno Moulin, Bertrand Knebelmann, Sylvie Chevret, Jean-Paul Fermand
Importance: Cast nephropathy is the main cause of acute kidney injury in multiple myeloma and persistent reduction in kidney function strongly affects prognosis. Strategies to rapidly remove nephrotoxic serum-free light chains combined with novel antimyeloma agents have not been evaluated prospectively. Objective: To compare the hemodialysis independence rate among patients newly diagnosed with myeloma cast nephropathy treated with hemodialysis using a high-cutoff dialyzer (with very large membrane pores and high permeability to immunoglobulin light chains) or a conventional high-flux dialyzer (with small pores and lower permeability)...
December 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29207633/camkii-is-involved-in-subcellular-ca2-redistribution-induced-endoplasmic-reticulum-stress-leading-to-apoptosis-in-primary-cultures-of-rat-proximal-tubular-cells-exposed-to-lead
#14
Min-Ge Wang, Wen-Hui Li, Xin-Yu Wang, Du-Bao Yang, Zhen-Yong Wang, Lin Wang
Lead (Pb) is a known nephrotoxic element. Recently we have proved that subcellular Ca2+ redistribution is involved in Pb-induced apoptosis in primary cultures of rat proximal tubular (rPT) cells, but the underlying mechanism remains to be elucidated. Firstly, data showed that Pb triggers endoplasmic reticulum (ER) stress response in rPT cells, as evidenced by the elevations of ER stress markers. Moreover, pharmacological modulation of Ca2+ mobilization in ER and cytoplasm with three chemicals (2-APB or TG or BAPTA-AM) can effectively increase or decrease the protein expression of ER stress markers in Pb-exposed rPT cells, demonstrating that Pb-induced ER stress is Ca2+-dependent...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206457/adverpred-web-service-for-prediction-of-adverse-effects-of-drugs
#15
Sergey M Ivanov, Alexey A Lagunin, Anastasia V Rudik, Dmitry A Filimonov, Vladimir V Poroikov
Application of structure-activity relationships (SARs) for the prediction of adverse effects of drugs (ADEs) has been reported in many published studies. Training sets for the creation of SAR models are usually based on drug label information which allows for the generation of datasets for many hundreds of drugs. Since many ADEs may not be related to drug consumption, one of the main problems in such studies is the quality of data on drug-ADE pairs obtained from labels. The information on ADEs may be included in three sections of the drug labels: "Boxed warning," "Warnings and Precautions" and "Adverse reactions...
December 5, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29204934/preventive-use-of-berberine-in-inhibition-of-lead-induced-renal-injury-in-rats
#16
Parisa Hasanein, Hassan Riahi
The kidney is one of the main organs affected by lead toxicity. We investigated the effects of berberine on lead-induced nephrotoxicity in adult male Wistar rats. Animals received an aqueous solution of lead acetate (500 mg Pb/L in the drinking water) and/or berberine (50 mg/kg, i.g.) for 8 weeks. Lead caused an increase in malondialdehyde (P < 0.001) and total oxidant status (P < 0.01), and a decrease in reduced glutathione (P < 0.001), catalase (P < 0.01), superoxide dismutase (P < 0...
December 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29203493/a-prospective-trial-on-the-use-of-trough-concentration-versus-area-under-the-curve-auc-to-determine-therapeutic-vancomycin-dosing
#17
Michael N Neely, Lauren Kato, Gilmer Youn, Lironn Kraler, David Bayard, Michael van Guilder, Alan Schumitzky, Walter Yamada, Brenda Jones, Emi Minejima
We hypothesized that dosing vancomycin to achieve trough concentrations >15 mg/L overdoses many adults compared to AUC-guided dosing. We conducted a 3-year, prospective study of vancomycin dosing, plasma concentrations, and outcomes. In year 1, non-study clinicians targeted trough concentrations of 10-20 mg/L (infection dependent) and controlled dosing. In years 2 and 3, the study team controlled vancomycin dosing with the BestDose Bayesian software to achieve a daily, steady-state AUC:MIC≥400, with maximum AUC 800 mg*h/L, regardless of trough concentration...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29203252/occurrence-and-improvement-of-renal-dysfunction-and-serum-potassium-abnormality-during-administration-of-liposomal-amphotericin-b-in-patients-with-hematological-disorders-a-retrospective-analysis
#18
Hiroyuki Yamazaki, Tadakazu Kondo, Kazunai Aoki, Kouhei Yamashita, Akifumi Takaori-Kondo
Liposomal amphotericin B (L-AMB) has the potential to cause two major adverse events, renal dysfunction and serum potassium abnormality; however, appropriate clinical management of these events remains unclear. We retrospectively analyzed data regarding 128 hematology patients who received L-AMB in our institute and examined the association between clinical characteristics and renal dysfunction or serum potassium abnormality. We found that the median weight-normalized dose of L-AMB was 2.69mg/kg and the median administration period was 16days...
November 7, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29202460/human-liver-kidney-model-elucidates-the-mechanisms-of-aristolochic-acid-nephrotoxicity
#19
Shih-Yu Chang, Elijah J Weber, Viktoriya S Sidorenko, Alenka Chapron, Catherine K Yeung, Chunying Gao, Qingcheng Mao, Danny Shen, Joanne Wang, Thomas A Rosenquist, Kathleen G Dickman, Thomas Neumann, Arthur P Grollman, Edward J Kelly, Jonathan Himmelfarb, David L Eaton
Environmental exposures pose a significant threat to human health. However, it is often difficult to study toxicological mechanisms in human subjects due to ethical concerns. Plant-derived aristolochic acids are among the most potent nephrotoxins and carcinogens discovered to date, yet the mechanism of bioactivation in humans remains poorly understood. Microphysiological systems (organs-on-chips) provide an approach to examining the complex, species-specific toxicological effects of pharmaceutical and environmental chemicals using human cells...
November 16, 2017: JCI Insight
https://www.readbyqxmd.com/read/29199592/nephrotoxicity-in-rats-exposed-to-paracetamol-the-protective-role-of-moralbosteroid-a-steroidal-glycoside
#20
Gaurav Gupta, Dinesh Kumar Chellappan, Irene Satiko Kikuchi, Terezinha de Jesus Andreoli Pinto, Kavita Pabreja, Mohit Agrawal, Yogendra Singh, Juhi Tiwari, Kamal Dua
Paracetamol (PCM) has an acceptable safety profile when used at prescribed doses. However, it is now understood that paracetamol can damage the kidneys when administered as an overdose. In addition, oxidative stress can play a major role in causing nephrotoxicity. This investigation studies the efficacy of moralbosteroid isolated from M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6)...
2017: Journal of Environmental Pathology, Toxicology and Oncology
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