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https://www.readbyqxmd.com/read/29027828/folate-decorated-and-nir-activated-nanoparticles-based-on-platinum-iv-prodrugs-for-targeted-therapy-of-ovarian-cancer
#1
Yu Sun, Tian-Yi Shi, Ling-Yun Zhou, Yu-Yan Zhou, Bai-Wang Sun, Xiao-Ping Liu
Platinum-based drugs are used to treat a variety of cancers but have many side effects such as nephrotoxicity and neurotoxicity. A folate-decorated nanoparticles system with a good drug payload can selectively deliver drugs into folate receptor (FR)-overexpressing cancer cells to prevent the shortcomings of platinum-based chemotherapy. Here, folate-decorated and near-infrared (NIR) laser-activated nanoparticles (abbreviated as Pt(IV)-FINPs) were prepared via ultrasonic self-assembling of platinum(IV) prodrug c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2, folic acid (FA)-functionalized lipid DSPE-PEG-FA and NIR fluorescent dye indocyanine green (ICG)...
October 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29026390/renal-histoarchitectural-changes-in-nevirapine-therapy-possible-role-of-kolaviron-and-vitamin-c-in-an-experimental-animal-model
#2
Ugochukwu Offor, Sunday Adelaja Ajayi, Isaac Ayoola Jegede, Salem Kharwa, Edwin Coleridge Naidu, Onyemaechi Okpara Azu
BACKGROUND: There is paucity of literature regarding the nephrotoxicity of antiretroviral drugs and its interaction with plant-based adjuvants. This study investigates the attenuating effect of kolaviron in nevirapine-therapy on the histological structure of the kidneys of adult male Sprague-Dawley rats. OBJECTIVE: To determine the attenuating influence of anti-oxidant status of kolaviron on the kidneys of experimental animals following nevirapine administration...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29024717/supplementation-of-american-ginseng-berry-extract-mitigated-cisplatin-evoked-nephrotoxicity-by-suppressing-ros-mediated-activation-of-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#3
Zhi-Na Ma, Zhi Liu, Zi Wang, Shen Ren, Shan Tang, Ying-Ping Wang, Sheng-Yuan Xiao, Chen Chen, Wei Li
Nephrotoxicity induced by cisplatin in 30% of all cisplatin treated patients seriously limits its clinical implication as a widely used anticancer agent, and may even cause patients to alter or give up cisplatin therapy. The purpose of this study is to test a protective effect of American ginseng berry extract (AGBE) on cisplatin-induced nephrotoxicity in mice. In this study, the histopathological changes and elevated levels of serum creatinine (CRE) and urea nitrogen (BUN) caused by cisplatin were significantly diminished by AGBE treatment...
October 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29023830/drug-management-in-acute-kidney-disease-report-of-the-adqi-xvi-meeting
#4
M Ostermann, L S Chawla, L G Forni, S L Kane-Gill, J A Kellum, J Koyner, P T Murray, C Ronco, S L Goldstein
AIMS: To summarize and extend the main conclusions and recommendations relevant to drug management during acute kidney disease (AKD) as agreed at the 16(th) Acute Disease Quality Initiative (ADQI) consensus conference. METHODS: Using a modified Delphi method to achieve consensus, experts attending the 16(th) ADQI consensus conference reviewed and appraised the existing literature on drug management during AKD and identified recommendations for clinical practice and future research...
October 11, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29023315/biomarkers-of-drug-induced-kidney-injury
#5
Lynn Redahan, Patrick Murray
PURPOSE OF REVIEW: Drug-induced kidney injury (DIKI) is an important and potentially modifiable cause of acute kidney injury (AKI). The reliance on traditional markers of kidney injury to diagnose DIKI impedes early detection. Biomarkers of DIKI that facilitate early diagnosis and the identification of high-risk patients are essential to ameliorate the clinical burden of this complication. RECENT FINDINGS: Recent progress in this area supports the potential utility of several biomarkers for the diagnosis of DIKI, for the prediction of outcomes and also for monitoring responses to potential nephrotoxic or beneficial therapies...
October 11, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29022917/trehalose-protects-against-cadmium-induced-cytotoxicity-in-primary-rat-proximal-tubular-cells-via-inhibiting-apoptosis-and-restoring-autophagic-flux
#6
Xin-Yu Wang, Heng Yang, Min-Ge Wang, Du-Bao Yang, Zhen-Yong Wang, Lin Wang
Autophagy has an important renoprotective function and we recently found that autophagy inhibition is involved in cadmium (Cd)-induced nephrotoxicity. Here, we aimed to investigate the protective effect of trehalose (Tre), a novel autophagy activator, against Cd-induced cytotoxicity in primary rat proximal tubular (rPT) cells. First, data showed that Tre treatment significantly decreased Cd-induced apoptotic cell death of rPT cells via inhibiting caspase-dependent apoptotic pathway, evidenced by morphological analysis, flow cytometric and immunoblot assays...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020764/incidence-and-risk-factors-for-tenofovir-associated-nephrotoxicity-among-human-immunodeficiency-virus-infected-patients-in-korea
#7
Jeong Eun Lee, Shinwon Lee, Sang Heon Song, Ihm Soo Kwak, Sun Hee Lee
Background/Aims: Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients in Korea. Methods: A single-center retrospective cohort study was conducted on HIVinfected patients in Korea. We included patients who had started TDF or abacavir (ABC)-based antiretroviral therapy (ART) between October 2006 and December 2014...
October 12, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29020249/increasing-evidence-of-the-nephrotoxicity-of-piperacillin-tazobactam-and-vancomycin-combination-therapy-what-is-the-clinician-to-do
#8
Richard R Watkins, Stan Deresinski
Early and appropriate empiric antibiotics are essential for achieving the best possible outcomes in sepsis. Yet, the choice of antibiotic therapy has become more challenging due to recent reports of nephrotoxicity with the combination of vancomycin and piperacillin/tazobactam, the "workhorse" regimen at many institutions. In this article we assess the evidence for nephrotoxicity and its possible mechanisms, provide recommendations for risk mitigation, address the advantages and disadvantages of alternative antibiotic choices, and suggest areas for future research...
July 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017888/impact-of-amikacin-pharmacokinetic-pharmacodynamics-ratio-on-treatment-response-in-critically-ill-patient
#9
Jesus Ruiz, Paula Ramirez, María José Company, Mónica Gordon, Esther Villarreal, Pablo Concha, María Aroca, Juan Frasquet, María Remedios Marqués, Álvaro Castellanos-Ortega
OBJECTIVE: To evaluate the association between pharmacokinetic and pharmacodynamic ratio and treatment response to amikacin in critically ill patients. MATERIAL AND METHODS: An observational prospective study was designed. Critically ill adult patients with an infection due to amikacin-sensitive gram-negative bacteria treated with amikacin were included. Amikacin maximum (Cmax) and minimum (Cmin) concentration samples were taken during the first 48h and 96h after the beginning of the treatment...
October 7, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29017666/protective-effects-of-nigella-sativaon-acetylsalicylic-acid-induced-nephrotoxicity-in-albino-rats
#10
Sania Asif, Lubna Malik
OBJECTIVE: To see the effects of Nigella sativaon acetylsalicylic acid-induced nephrotoxicity in albino rats. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: The Anatomy Department of University of Health Sciences, Lahore, from January 2014 to December 2015. METHODOLOGY: Thirty-two female albino rats were divided into four groups. Group A(control) was given single dose of 10 mg/100 gm body weight of 1% methylcellulose, orally...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29016288/efficacy-and-safety-of-liposomal-amphotericin-b-for-visceral-leishmaniasis-in-children-and-adolescents-at-a-tertiary-care-center-in-bihar-india
#11
Krishna Pandey, Biplab Pal, Niyamat Ali Siddiqui, Vidya Nand Rabi Das, Krishna Murti, Chandra Shekhar Lal, Neena Verma, Rajendra Babu, Vahab Ali, Rakesh Kumar, Pradeep Das
Liposomal amphotericin B is being used increasingly to reduce the burden of kala-azar from the Indian subcontinent. There are studies which have evaluated efficacy and safety of liposomal amphotericin B for visceral leishmaniasis in all age groups. However, the only study that specifically addressed treatment of childhood visceral leishmaniasis did not include all ages or document renal and liver function. We, therefore, felt it was important to reassess the efficacy and safety of single dose liposomal amphotericin B in children and adolescents...
September 5, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28993214/a-comprehensive-review-on-biological-properties-of-citrinin
#12
José Williams G de Oliveria Filho, Muhammad Torequl Islam, Eunus S Ali, Shaikh Jamal Uddin, Jose Victor de Oliveira Santos, Marcus Vinícius Oliveira Barros de Alencar, Antonio Luiz Gomes Júnior, Márcia Fernanda Correia Jardim Paz, Maria Dos Remédios Mendes de Brito, João Marcelo de Castro E Sousa, Subrata Shaw, Maria das Graças Freire de Medeiros, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Paulo Michel Pinheiro Ferreira, Mohammad Amjad Kamal, Magdalena D Pieczynska, Niranjan Das, Vijai K Gupta, Andrei Mocan, Teresinha de Jesus Aguiar Dos Santos Andrade, Brahma Nand Singh, Siddhartha K Mishra, Atanas G Atanasov, Ana Amélia de Carvalho Melo-Cavalcante
Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive...
October 6, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28989114/is-a-randomized-trial-of-a-short-course-of-aminoglycoside-added-to-beta-lactam-antibiotics-for-empirical-treatment-in-critically-ill-patients-with-sepsis-justified
#13
David S Y Ong, Cornelis H van Werkhoven, Olaf L Cremer, Guy E Thwaites, Marc J M Bonten
Short-term adjunctive treatment with aminoglycosides in critically ill patients is advocated in guidelines for the empirical treatment of sepsis, despite lack of evidence from randomized trials. A large observational study recently reported more nephrotoxicity and a trend to worse patient outcome in critically ill patients receiving aminoglycosides added to beta-lactam antibiotics. Here, we discuss if a randomized controlled trial to obtain a more definite answer is justified and how it could be performed.
October 5, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28988613/amelioration-of-panadol-induced-nephrotoxicity-via-down-regulation-of-bax-bcl2-ratio-with-some-antioxidants
#14
Nouf Al-Rasheed, Laila M Faddah, Iman H Hasan, Hanaa M Ali, Nawal Al-Rasheed, Nagla F El Oraby, Mahmoud H Mohamed
BACKGROUND: Overdoses of Panadol (APAP) result in hepatic and renal toxicity. Up till now, there is no effective drug for APAP-enhanced nephrotoxicity. This work aims to explore the protective effects of N-acetylcysteine, Thymoquinone (THQ), Curcumin (CUR) and α-Lipoic acid (LA) either alone or in combination against APAP nephrotoxicity, focused on modulation of Bax/Bcl2 pathway. METHODS: APAP was administrated at a single dose then treated with the fore mentioned antioxidants...
May 6, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28987366/the-impact-of-gallic-acid-on-the-methotrexate-induced-kidney-damage-in-rats
#15
Halil Asci, Ozlem Ozmen, Hamit Yasar Ellidag, Bunyamin Aydin, Ercan Bas, Necat Yilmaz
Prolonged use of an antineoplastic agent methotrexate (MTX), can cause numerous side effects such as nephrotoxicity. The aim of this study was to examine the effects of MTX on kidneys and demonstrate the protective effects of gallic acid (GA). Twenty-four, male, rats distributed into three groups. Each groups consisted eight rats and only saline was administered to the control group. The MTX group received a single dose (20 mg/kg) MTX intraperitoneally. The MTX + GA group received same dose MTX and 100 mg/kg GA orally during the 7 days...
October 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28986476/colistin-is-substrate-of-the-carnitine-organic-cation-transporter-2-octn2-slc22a5
#16
Michele Visentin, Zhibo Gai, Angelo Torozi, Christian Hiller, Gerd A Kullak-Ublick
Colistin is a polycation antibiotic used for the treatment of multidrug-resistance (MDR) gram-negative infections; nevertheless, its use is often limited by the high incidence of renal damage. The mechanism underlying colistin-induced nephrotoxicity is not known, but perhaps related to its accumulation in the renal cortex upon extensive reabsorption from the nascent urine. Because little is known about the membrane transport of colistin, the purpose of the present study was to characterize better the transport system involved in colistin renal handling by using HEK293 cells stably transfected with the main organic cation transporters expressed at the apical membrane of the proximal tubule...
October 6, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28986290/assessment-of-hepatic-metabolism-dependent-nephrotoxicity-on-an-organs-on-a-chip-microdevice
#17
Zhongyu Li, Lei Jiang, Yujuan Zhu, Wentao Su, Cong Xu, Tingting Tao, Yang Shi, Jianhua Qin
Drug-induced nephrotoxicity is one of the most frequent adverse events in pharmacotherapy. It has resulted in numerous clinical trial failures and high drug development costs. The predictive capabilities of existing in vitro models are limited by their inability to recapitulate the complex process of drug metabolism at the multi-organ level in vivo. We present a novel integrated liver-kidney chip that allows the evaluation of drug-induced nephrotoxicity following liver metabolism in vitro. The liver-kidney chip consists of two polydimethylsiloxane layers with compartmentalized micro-channels separated by a porous membrane...
October 3, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28984058/multivariate-analysis-of-risk-factors-for-cisplatin-induced-nephrotoxicity-in-gynecological-cancer
#18
Yoshihiro Yamamoto, Kazushi Watanabe, Hiroshi Matsushita, Ikuto Tsukiyama, Katsuhiko Matsuura, Akihiko Wakatsuki
AIM: Risk factors for cisplatin-induced nephrotoxicity (CIN) vary by population. This study aimed to assess risk factors for CIN in patients with gynecological cancer. METHODS: Patients who underwent cisplatin-based chemotherapy for gynecological cancer between January 2009 and December 2015 at Aichi Medical University School of Medicine were included in this study. CIN was defined according to the 'risk, injury, failure, loss, and end-stage kidney disease' (RIFLE) criteria and classified as either risk (Class R) or injury (Class I)...
October 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28983943/delayed-methotrexate-elimination-incidence-interaction-with-antacid-drugs-and-clinical-consequences
#19
Florence Ranchon, Nicolas Vantard, Emilie Henin, Emmanuel Bachy, Clémentine Sarkozy, Lionel Karlin, Fadhela Bouafia-Sauvy, Aurore Gouraud, Verane Schwiertz, Estelle Bourbon, Amandine Baudouin, Anne Gaelle Caffin, Thierry Vial, Gilles Salles, Catherine Rioufol
The aim of this retrospective cohort study was to investigate the incidence of delayed methotrexate elimination in patients treated with high-dose methotrexate (≥1 g/m(2) ) for haematological malignancy and to identify the impact of interacting drugs, especially proton-pump inhibitors (PPIs) and ranitidine. All patients treated with high-dose methotrexate over a 6 year period in the haematology department of the Lyon Sud University Hospital (Hospices Civils de Lyon, France) were included. Potential risk factors for delayed methotrexate elimination were tested in a generalized linear model by univariate analysis: patient age, gender, methotrexate dose, administration of PPI or ranitidine, and concomitant nephrotoxic drugs...
October 6, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28979780/lesinurad-what-the-nephrologist-should-know
#20
Maria Dolores Sanchez-Niño, Binbin Zheng-Lin, Lara Valiño-Rivas, Ana Belen Sanz, Adrian Mario Ramos, Jose Luño, Marian Goicoechea, Alberto Ortiz
Lesinurad is an oral inhibitor of the monocarboxylic/urate transporter URAT1 encoded by the SLC22A12 gene. Market authorization was granted in February 2016 in Europe and December 2015 in the USA. As a potentially nephrotoxic uricosuric drug acting on the kidney, nephrologists should become familiar with its indications and safety profile. The approved indication is treatment of gout in combination with a xanthine oxidase (XO) inhibitor in adult patients who have not achieved target serum uric acid levels with an XO inhibitor alone...
October 2017: Clinical Kidney Journal
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