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https://www.readbyqxmd.com/read/29334602/high-dose-metformin-plus-temozolomide-shows-increased-anti-tumor-effects-in-glioblastoma-in-vitro-and-in-vivo-compared-with-monotherapy
#1
Jung Eun Lee, Ji Hee Lim, Yong Kil Hong, Seung Ho Yang
Purpose: The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in vitro and in vivo. Materials and Methods: We investigated the efficacy of combined treatment with TMZ and metformin using cell viability and apoptosis assays. A GBM orthotopic mice model was established by inoculation of 5x105 U87 cells and treated with metformin, TMZ, and the combination for 4 weeks. Western blotting and immunofluorescence of tumor specimens were analyzed to investigate AMP-activated protein kinase (AMPK) and AKT pathway...
January 10, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29334505/the-association-of-chronic-air-pollutants-with-coronary-artery-spasm-vasospastic-angina-and-endothelial-dysfunction
#2
Byoung Geol Choi, Jiwon Lee, Suhng Wook Kim, Min Woo Lee, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha
BACKGROUND: We evaluated the effect of chronic exposure to air pollutants (APs) on coronary endothelial function and significant coronary artery spasm (CAS) as assessed by intracoronary acetylcholine (ACH) provocation test. PATIENTS AND METHODS: A total of 6430 patients with typical or atypical chest pain who underwent intracoronary ACH provocation test were enrolled. We obtained data on APs from the Korean National Institute of Environmental Research (http://www...
January 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29334442/a-rare-initial-presentation-of-primary-diffuse-leptomeningeal-pnet-in-a-10-year-old-male
#3
Peter Paul Lim, Jagadeesh Ramdas, Michal Ann Miller, Conrad Schuerch, George Wu
Primary leptomeningeal primitive neuroectodermal tumors (PNETs) are extremely rare childhood central nervous system malignancies harboring a very poor prognosis. There is no consensus treatment for these tumors to date. We report a case of a 10-year-old male who presented with mental status change, hydrocephalus, intracranial and spinal diffuse leptomeningeal enhancement without a primary mass upon cranial imaging and a negative initial biopsy until five months into his presentation. He responded significantly well to initial chemotherapy and radiotherapy...
December 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29334430/preclinical-therapeutic-efficacy-of-the-ciprofloxacin-eluting-sinus-stent-for-pseudomonas-aeruginosa-sinusitis
#4
Do-Yeon Cho, Dong-Jin Lim, Calvin Mackey, Daniel Skinner, Christopher Weeks, Gobind S Gill, Robert W Hergenrother, William E Swords, Bradford A Woodworth
BACKGROUND: The ciprofloxacin-coated sinus stent (CSS) has unique therapeutic potential to deliver antibiotics to the sinuses. The objective of this study is to evaluate the efficacy of the CSS stent in eliminating Pseudomonas aeruginosa infection in a rabbit model of sinusitis. METHODS: A ciprofloxacin-eluting sinus stent was created by coating ciprofloxacin/Eudragit RS100 on biodegradable poly-D/L-lactic acid (2 mg). After analyzing in-vitro inhibition of P aeruginosa (PAO-1 strain) biofilm formation, a total of 8 stents (4 shams, 4 CSSs) were placed unilaterally in rabbit maxillary sinuses via dorsal sinusotomy after inducing infection for 1 week with PAO-1...
January 15, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29334268/analysis-of-the-development-and-progression-of-carbon-monoxide-poisoning-related-acute-kidney-injury-according-to-the-kidney-disease-improving-global-outcomes-kdigo-criteria
#5
Youn-Jung Kim, Chang Hwan Sohn, Dong-Woo Seo, Bum Jin Oh, Kyoung Soo Lim, Jai Won Chang, Won Young Kim
CONTEXT: Acute kidney injury (AKI) can occur after carbon monoxide (CO) intoxication; however, limited data are available. This study aimed to evaluate the prognostic value of the development and progression of AKI in patients with acute CO poisoning. MATERIALS AND METHODS: We conducted a retrospective cohort study using a prospective registry of CO poisoning between January 2010 and December 2015. AKI was defined and classified according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria...
January 15, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29333877/what-behaviors-do-young-heterosexual-australians-see-in-pornography-a-cross-sectional-study
#6
Angela C Davis, Elise R Carrotte, Margaret E Hellard, Megan S C Lim
This study investigated how frequently a group of young heterosexual Australians (ages 15 to 29) saw a range of behaviors represented in pornography over the previous 12 months. Participants were recruited to an anonymous online survey. Those who reported having viewed pornography in the past 12 months (n = 517) indicated how frequently they saw each of a list of 17 behaviors when they watched pornography in the past 12 months. Men's pleasure (83%) was seen frequently by the highest proportion of young people surveyed, followed by a man being portrayed as dominant (70%)...
January 15, 2018: Journal of Sex Research
https://www.readbyqxmd.com/read/29333762/pemphigus-herpetiformis-with-autoantibodies-to-desmocollins-1-2-and-3
#7
Y E Tay, S S J Lee, Y L Lim
No abstract text is available yet for this article.
January 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29333736/underestimated-caregiver-burden-by-cancer-patients-and-its-association-with-quality-of-life-depression-and-anxiety-among-caregivers
#8
J Y Shin, J-W Lim, D W Shin, S Y Kim, H-K Yang, J Cho, A Jeong, D Jo, C-Y Yim, K Park, J-H Park
This study examined how patients with cancer estimate caregiver burden (CB) and the association between their underestimation of CB and their caregivers' self-ratings of their quality of life (CQOLC-K; Korean version of the Caregiver Quality of Life Index-Cancer), depression and anxiety (Korean version of the Hospital Anxiety and Depression Scale). Participants consisted of 990 patient-caregiver dyads recruited from a nationwide cross-sectional survey conducted in South Korea. Medical baseline data were retrieved from the hospital information systems of the participating centres...
January 15, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29333427/surgery-of-multiple-lymphangioma-in-small-bowel-a-rare-case-report-of-chronic-gastrointestinal-bleeding
#9
Dae Ro Lim, Jung Cheol Kuk, Taehyung Kim, Eung Jin Shin
Small bowel lymphangioma is a rare benign tumor of the lymphatic system, characterized by the presence of dilated lymphatic spaces and significant gastrointestinal bleeding. Small bowel lymphangiomas are rare in adults and case reports are few. Lymphangiomas in the jejunum or ileum are extremely rare and account for less than 1% of all lymphangiomas. The case reported herein is of an older patient (70-year-old male) with melena and chronic anemia (hemoglobin count < 5 g/dL) who had small-sized multiple lymphangiomas in his small bowel (jejunum)...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29333422/epigenetic-inactivation-of-runx3-in-colorectal-cancer
#10
Eung Jin Shin, Han Jo Kim, Myoung Won Son, Tae Sung Ahn, Hyun Yong Lee, Dae Ro Lim, Sang Byung Bae, Seob Jeon, Hyungjoo Kim, Dongjun Jeong, Moon Soo Lee, Dong-Sun Kim, Jeong Se Noh, Moo-Jun Baek
Purpose: Emerging evidence indicates that runt-related transcription factor 3 (RUNX3) is an important tumor suppressor gene in several cancer types, including colorectal cancer (CRC). However, the clinical significance of RUNX3 inactivation in CRC remains unclear. The aim of this study was to examine the correlation between clinicopathologic factors and RUNX3 hypermethylation/expression in CRC. Methods: Sixty-two CRC patients who were treated at the Soonchunhyang University College of Medicine were recruited in this study...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29333401/management-of-immune-thrombocytopenia-korean-experts-recommendation-in-2017
#11
REVIEW
Jun Ho Jang, Ji Yoon Kim, Yeung-Chul Mun, Soo-Mee Bang, Yeon Jung Lim, Dong-Yeop Shin, Young Bae Choi, Ho-Young Yhim, Jong Wook Lee, Hoon Kook
Management options for patients with immune thrombocytopenia (ITP) have evolved substantially over the past decades. The American Society of Hematology published a treatment guideline for clinicians referring to the management of ITP in 2011. This evidence-based practice guideline for ITP enables the appropriate treatment of a larger proportion of patients and the maintenance of normal platelet counts. Korean authority operates a unified mandatory national health insurance system. Even though we have a uniform standard guideline enforced by insurance reimbursement, there are several unsolved issues in real practice in ITP treatment...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29333388/enhancement-of-phenolic-production-and-antioxidant-activity-from-buckwheat-leaves-by-subcritical-water-extraction
#12
Dong-Shin Kim, Mi-Bo Kim, Sang-Bin Lim
To enhance the production of phenolic compounds with high antioxidant activity and reduce the level of phototoxic fagopyrin, buckwheat leaves were extracted with subcritical water (SW) at 100~220°C for 10~50 min. The major phenolic compounds were quercetin, gallic acid, and protocatechuic acid. The cumulative amount of individual phenolic compounds increased with increasing extraction temperature from 100°C to 180°C and did not change significantly at 200°C and 220°C. The highest yield of individual phenolic compounds was 1,632...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29333352/smartphone-based-point-of-care-urinalysis-under-variable-illumination
#13
Moonsoo Ra, Mannan Saeed Muhammad, Chiawei Lim, Sehui Han, Chansung Jung, Whoi-Yul Kim
Urine tests are performed by using an off-the-shelf reference sheet to compare the color of test strips. However, the tabular representation is difficult to use and more prone to visual errors, especially when the reference color-swatches to be compared are spatially apart. Thus, making it is difficult to distinguish between the subtle differences of shades on the reagent pads. This manuscript represents a new arrangement of reference arrays for urine test strips (urinalysis). Reference color swatches are grouped in a doughnut chart, surrounding each reagent pad on the strip...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29333323/alveolar-ridge-preservation-with-an-open-healing-approach-using-single-layer-or-double-layer-coverage-with-collagen-membranes
#14
Ho-Keun Choi, Hag-Yeon Cho, Sung-Jo Lee, In-Woo Cho, Hyun-Seung Shin, Ki-Tae Koo, Hyun-Chang Lim, Jung-Chul Park
Purpose: The aim of this prospective pilot study was to compare alveolar ridge preservation (ARP) procedures with open-healing approach using a single-layer and a double-layer coverage with collagen membranes using radiographic and clinical analyses. Methods: Eleven molars from 9 healthy patients requiring extraction of the maxillary or mandibular posterior teeth were included and allocated into 2 groups. After tooth extraction, deproteinized bovine bone mineral mixed with 10% collagen was grafted into the socket and covered either with a double-layer of resorbable non-cross-linked collagen membranes (DL group, n=6) or with a single-layer (SL group, n=5)...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29333222/congenital-left-atrial-bands-with-atrial-fibrillation
#15
Won Young Jang, Woohyeun Kim, Eun Jin Park, Jah Yeon Choi, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Seung-Woon Rha, Jin Oh Na
No abstract text is available yet for this article.
December 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29332715/prevalence-of-gastrointestinal-comorbidities-in-rosacea-comparison-of-subantimicrobial-modified-release-doxycycline-versus-conventional-release-doxycycline
#16
Hester Gail Lim, Alexander Fischer, Maria Jose Rueda, James Kendall, Sewon Kang, Anna L Chien
No abstract text is available yet for this article.
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29332323/development-of-prediction-equation-of-diffusing-capacity-of-lung-for-koreans
#17
Yong Il Hwang, Yong Bum Park, Hyoung Kyu Yoon, Seong Yong Lim, Tae Hyung Kim, Joo Hun Park, Won Yeon Lee, Seong Ju Park, Sei Won Lee, Woo Jin Kim, Ki Uk Kim, Kyeong Cheol Shin, Do Jin Kim, Hui Jung Kim, Tae Eun Kim, Kwang Ha Yoo, Jae Jeong Shim
BACKGROUND: The diffusing capacity of the lung is influenced by multiple factors such as age, sex, height, weight, ethnicity and smoking status. Although a prediction equation for the diffusing capacity of Korea was proposed in the mid-1980s, this equation is not used currently. The aim of this study was to develop a new prediction equation for the diffusing capacity for Koreans. METHODS: Using the data of the Korean National Health and Nutrition Examination Survey, a total of 140 nonsmokers with normal chest X-rays were enrolled in this study...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29332238/normal-variation-in-sagittal-spinal-alignment-parameters-in-adult-patients-an-eos-study-using-serial-imaging
#18
Hwee Weng Dennis Hey, Kian Loong Melvin Tan, Vikaesh Moorthy, Eugene Tze-Chun Lau, Leok-Lim Lau, Gabriel Liu, Hee-Kit Wong
PURPOSE: To describe normal variations in sagittal spinal radiographic parameters over an interval period and establish physiological norms and guidelines for which these images should be interpreted. METHODS: Data were prospectively collected from a continuous series of adult patients with first-episode mild low back pain presenting to a single institution. The sagittal parameters of two serial radiographic images taken 6-months apart were obtained with the EOS® slot scanner...
January 13, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29331952/inter-relationship-between-ocular-perfusion-pressure-blood-pressure-intraocular-pressure-profiles-and-primary-open-angle-glaucoma-the-singapore-epidemiology-of-eye-diseases-study
#19
Yih-Chung Tham, Sing-Hui Lim, Preeti Gupta, Tin Aung, Tien Y Wong, Ching-Yu Cheng
OBJECTIVE: To elucidate the inter-relationship between ocular perfusion pressure (OPP), blood pressure (BP), intraocular pressure (IOP) profiles and primary open-angle glaucoma (POAG) in a multiethnic Asian population. METHODS: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study and underwent standardised ocular and systemic examinations. POAG was defined according to the International Society for Geographical and Epidemiological Ophthalmology criteria...
January 13, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29331947/response-to-prognosis-of-immune-tolerant-phase-chronic-hepatitis-b-by-chu-and-liaw
#20
Gi-Ae Kim, Young-Suk Lim
No abstract text is available yet for this article.
January 13, 2018: Gut
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