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https://www.readbyqxmd.com/read/29045981/renal-ewing-s-sarcoma-primitive-neuroectodermal-tumor-a-case-report-and-literature-review
#1
C Liu, L G Cui, H L Wang
Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) in the kidney is a rare but high-grade malignant tumor that affects predominantly elder children and adolescents. Patients mostly present with nonspecific symptoms such as abdominal pain and gross hematuria. Since EWS/PNET has a rapid clinical progression with early metastasis and death, it is essential to make an accurate and early diagnosis. Once diagnosed, multimodality treatment, including radical surgery combined with adjuvant chemotherapy, and radiotherapy if necessary, is recommended...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045673/age-related-changes-in-the-mitochondria-of-human-mural-granulosa-cells
#2
Yifan Liu, Ming Han, Xiaoshuang Li, Hui Wang, Minyue Ma, Shihui Zhang, Yifan Guo, Shuling Wang, Yuanfen Wang, N Duan, Bing Xu, Jingwen Yin, Yuanqing Yao
STUDY QUESTION: What changes in the mitochondria of human mural granulosa cells (mGCs) with maternal aging? SUMMARY ANSWER: The mitochondrial membrane potential (MMP) and the ability of oxidative phosphorylation (OXPHOS) of mGCs declines with reproductive aging, accompanied with more abnormal mitochondria. WHAT IS KNOWN ALREADY: Mitochondria play an important role in the dialogue between the mGCs and oocytes. However, the underlying mechanism of mitochondrial dysfunction in mGCs in aging is still poorly understood...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29045651/clinical-decision-support-alert-malfunctions-analysis-and-empirically-derived-taxonomy
#3
Adam Wright, Angela Ai, Joan Ash, Jane F Wiesen, Thu-Trang T Hickman, Skye Aaron, Dustin McEvoy, Shane Borkowsky, Pavithra I Dissanayake, Peter Embi, William Galanter, Jeremy Harper, Steve Z Kassakian, Rachel Ramoni, Richard Schreiber, Anwar Sirajuddin, David W Bates, Dean F Sittig
Objective: To develop an empirically derived taxonomy of clinical decision support (CDS) alert malfunctions. Materials and Methods: We identified CDS alert malfunctions using a mix of qualitative and quantitative methods: (1) site visits with interviews of chief medical informatics officers, CDS developers, clinical leaders, and CDS end users; (2) surveys of chief medical informatics officers; (3) analysis of CDS firing rates; and (4) analysis of CDS overrides. We used a multi-round, manual, iterative card sort to develop a multi-axial, empirically derived taxonomy of CDS malfunctions...
October 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29045420/inhibition-of-apoptosis-signal-regulating-kinase-1-alters-the-wound-epidermis-and-enhances-auricular-cartilage-regeneration
#4
Qian-Shi Zhang, Deepa S Kurpad, My G Mahoney, Marla J Steinbeck, Theresa A Freeman
Why regeneration does not occur in mammals remains elusive. In lower vertebrates, epimorphic regeneration of the limb is directed by the wound epidermis, which controls blastema formation to promote regrowth of the appendage. Herein, we report that knockout (KO) or inhibition of Apoptosis Signal-regulated Kinase-1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), after full thickness ear punch in mice prolongs keratinocyte activation within the wound epidermis and promotes regeneration of auricular cartilage...
2017: PloS One
https://www.readbyqxmd.com/read/29045357/clinical-effectiveness-and-cost-of-a-hospital-based-fall-prevention-intervention-the-importance-of-time-nurses-spend-on-the-front-line-of-implementation
#5
Teryl K Nuckols, Jack Needleman, Tristan R Grogan, Li-Jung Liang, Pamela Worobel-Luk, Laura Anderson, Linda Czypinski, Courtney Coles, Catherine M Walsh
OBJECTIVE: The aim of this study is to evaluate the clinical effectiveness and incremental net cost of a fall prevention intervention that involved hourly rounding by RNs at 2 hospitals. BACKGROUND: Minimizing in-hospital falls is a priority, but little is known about the value of fall prevention interventions. METHODS: We used an uncontrolled before-after design to evaluate changes in fall rates and time use by RNs. Using decision-analytical models, we estimated incremental net costs per hospital per year...
October 17, 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29045340/cause-of-renal-infarction-a-retrospective-analysis-of-186-consecutive-cases
#6
Anne-Laure Faucon, Guillaume Bobrie, Anne-Sophie Jannot, Arshid Azarine, Pierre-François Plouin, Michel Azizi, Laurence Amar
BACKGROUND: Renal infarction can cause abrupt and severe hypertension and less frequently renal failure. Renal infarction results from disruption of renal blood flow in the main ipsilateral renal artery or in a segmental branch. Underlying mechanism is either general, 'embolic' or 'thrombophilic', or local related to primary 'renal artery lesion'. It depends on various causes. In absence of an identified cause, renal infarction is classified as 'idiopathic'. Previous studies report a significant number of 'idiopathic' renal infarction...
October 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29044913/assessment-of-cytologic-differentiation-in-high-grade-pancreatic-neuroendocrine-neoplasms-a-multi-institutional-study
#7
Carlie S Sigel, Vitor Werneck Krauss Silva, Michelle D Reid, David Chhieng, Olca Basturk, Keith M Sigel, Tanisha D Daniel, David S Klimstra, Laura H Tang
BACKGROUND: Well-differentiated (WD) and poorly differentiated (PD) pancreatic neuroendocrine neoplasms are biologically distinct entities with different therapies and prognoses. WD neoplasms with elevated proliferation (Ki-67 > 20%) have been shown to have an overlapping histology with PD neuroendocrine carcinomas. This study compared expert cytomorphologic assessments of differentiation in pancreatic neuroendocrine neoplasms in a multi-institutional study. METHODS: Fine-needle aspiration specimens from pancreatic neuroendocrine neoplasms (grade 2 [G2] and grade 3 [G3] according to the 2017 World Health Organization classification; n = 72) were diagnosed independently by 3 cytopathologists as WD or PD (poorly differentiated large cell type [PD-L] or poorly differentiated small cell type [PD-S]) purely on the basis of cytomorphology...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29044722/alopecic-and-aseptic-nodule-of-the-scalp-in-a-girl
#8
Erika Rodríguez-Lobato, Daniel Morgado-Carrasco, Priscila Giavedoni, Juan Ferrando
Alopecic and aseptic nodule of the scalp is a rare entity characterized by the presence of nodules or cysts with sterile punctured material and negative cultures accompanied by nonscarring alopecia in the scalp of young men. We describe a case in which an 11-year-old girl presented with a nodular, fluctuant, round lesion on the vertex with localized alopecia. High-resolution ultrasound showed a hypoechoic lesion with increased flow on Doppler imaging and culture of the citrine-yellowish material obtained by puncture was negative...
October 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29044130/long-term-passive-acoustic-recordings-track-the-changing-distribution-of-north-atlantic-right-whales-eubalaena-glacialis-from-2004-to-2014
#9
Genevieve E Davis, Mark F Baumgartner, Julianne M Bonnell, Joel Bell, Catherine Berchok, Jacqueline Bort Thornton, Solange Brault, Gary Buchanan, Russell A Charif, Danielle Cholewiak, Christopher W Clark, Peter Corkeron, Julien Delarue, Kathleen Dudzinski, Leila Hatch, John Hildebrand, Lynne Hodge, Holger Klinck, Scott Kraus, Bruce Martin, David K Mellinger, Hilary Moors-Murphy, Sharon Nieukirk, Douglas P Nowacek, Susan Parks, Andrew J Read, Aaron N Rice, Denise Risch, Ana Širović, Melissa Soldevilla, Kate Stafford, Joy E Stanistreet, Erin Summers, Sean Todd, Ann Warde, Sofie M Van Parijs
Given new distribution patterns of the endangered North Atlantic right whale (NARW; Eubalaena glacialis) population in recent years, an improved understanding of spatio-temporal movements are imperative for the conservation of this species. While so far visual data have provided most information on NARW movements, passive acoustic monitoring (PAM) was used in this study in order to better capture year-round NARW presence. This project used PAM data from 2004 to 2014 collected by 19 organizations throughout the western North Atlantic Ocean...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044005/analysis-on-the-treatment-and-prevention-of-epidemic-conjunctivitis-in-108-cases
#10
Guangli Sun, Gang Su, Yanhui Bai, Huiqin Yang
To explore the treatment method and preventive measures on epidemic keratoconjunctivitis. 108 patients with epidemic keratoconjunctivitis who received treatment in our hospital from January, 2015 to September, 2015.were selected. These patients were treated with interferon eye drops, Ganciclovir ophthalmic gel, and alternating eye treatment of tobramycin-dexamethasone eye drops and diclofenac sodium eye drops. Meanwhile, health education was also performed among patients, so as to promote the recovery of the disease as soon as possible and to prevent the spread of the disease Among the 108 patients, there were 101 patients recovered...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29043760/retail-food-environments-shopping-experiences-first-nations-and-the-provincial-norths
#11
Kristin Burnett, Kelly Skinner, Travis Hay, Joseph LeBlanc, Lori Chambers
INTRODUCTION: This paper looks at the market food environments of First Nations communities located in the provincial Norths by examining the potential retail competition faced by the North West Company (NWC) and by reporting on the grocery shopping experiences of people living in northern Canada. METHODS: We employed two methodological approaches to assess northern retail food environments. First, we mapped food retailers in the North to examine the breadth of retail competition in the provincial Norths, focussing specifically on those communities without year-round road access...
October 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29043662/stryphnodendron-adstringens-barbatim%C3%A3-o-leaf-fraction-chemical-characterization-antioxidant-activity-and-cytotoxicity-towards-human-breast-cancer-cell-lines
#12
A P L Sabino, L M S Eustáquio, A C F Miranda, C Biojone, T N Mariosa, Cibele Marli Cação Paiva Gouvêa
We evaluated the chemical composition, antioxidant activity, and antitumor potential of a fraction that was isolated from Stryphnodendron adstringens (barbatimão) leaf aqueous extract. Fraction is composed by gallic acid, procyanidin dimer B1, and (-)-epicatechin-3-O-gallate and it exhibits antioxidant and cytotoxic activities. Fraction was cytotoxic against two human breast cancer cell lines, ER (+) and MCF-7 and the triple-negative, MDA-MB-435. The sulforhodamine B assay showed that, as compared to normal control cells, the fraction significantly (P < 0...
October 17, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29043594/specialty-care-access-network-extension-of-community-healthcare-outcomes-model-program-for-liver-disease-improves-specialty-care-access
#13
Lisa M Glass, Akbar K Waljee, Heather McCurdy, Grace L Su, Anne Sales
BACKGROUND AND AIMS: To improve subspecialty access, VA Ann Arbor Healthcare System (VAAAHS) implemented the first Specialty Care Access Network (SCAN)-Extension of Community Healthcare Outcomes (ECHO) in chronic liver disease. SCAN-ECHO Liver links primary care providers (PCPs) to hepatologists via secure video-teleconferencing. We aim to describe characteristics of participants (PCPs) and patients (clinical question and diagnosis) in SCAN-ECHO Liver. METHODS: This is a prospective study of the VAAAHS SCAN-ECHO Liver (June 10, 2011-March 31, 2015)...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29043558/enriched-expression-of-neutral-sphingomyelinase-2-in-the-striatum-is-essential-for-regulation-of-lipid-raft-content-and-motor-coordination
#14
Laura Hui-Ru Tan, Angela Jin-Rong Tan, Yu-Ying Ng, John Jia-En Chua, Wee-Siong Chew, Sneha Muralidharan, Federico Torta, Bamaprasad Dutta, Siu Kwan Sze, Deron R Herr, Wei-Yi Ong
Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral sphingomyelinase 2 (nSMase2) were elucidated in this study. nSMase2 mRNA expression was greatest in the striatum, followed by the prefrontal cortex, hippocampus, cerebellum, thalamus, brainstem, and olfactory bulb. The striatum had the highest level of nSMase2 protein expression, followed by the prefrontal cortex, thalamus, hippocampus, brainstem, and cerebellum...
October 17, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29043531/desmoplastic-small-round-cell-tumor-presenting-as-an-ocular-mass-unusual-localization-and-remarkable-surgical-approach
#15
REVIEW
H Bengu Cobanoglu, Ehab Y Hanna, Diana Bell, Bita Esmaeli
Desmoplastic small round cell tumor (DSRCT) is a rare tumor that was first described by Gerald and Rosai in 1989 as a mesenchymal entity. This tumor has a unique translocation t (11:22) (p:13, q:12) resulting in EWS/WT1 gene fusion that is diagnostic for DSCRT. The overall prognosis for desmoplastic small round cell tumor remains extremely poor, with reported rates of death as high as 90%. Although the majority of patients undergo chemotherapy following surgery, the prognosis has been shown to be independent of whether the surgical process preceded or followed chemotherapy...
October 18, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/29043464/the-importance-of-early-detection-of-calcifications-associated-with-breast-cancer-in-screening
#16
J J Mordang, A Gubern-Mérida, A Bria, F Tortorella, R M Mann, M J M Broeders, G J den Heeten, N Karssemeijer
PURPOSE: The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer. METHODS: From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with a screen-detected cancer and a prior negative exam, 781 women with a false positive exam based on calcifications, and 413 women with an interval cancer. A radiologist identified cancer-related calcifications, selected by a computer-aided detection system, on mammograms taken prior to screen-detected or interval cancer diagnoses...
October 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29042826/clinical-reasoning-and-knowledge-management-in-final-year-medical-students-the-role-of-student-led-grand-rounds
#17
David Arumaisingam Kandiah
OBJECTIVES: The development of clinical reasoning and decision-making skills is often limited in medical school curricula. In reality, medical graduates acquire these skills during their first few years of residency. For many, this can be stressful as they may be working under limited supervision as a part of their rotations. METHODS: Student-led Grand Rounds was developed to transfer both explicit and tacit knowledge to final year medical students. This pilot project was to apply the principles of knowledge management to allow students to be exposed to the reasoning and decision making of common clinical presentations...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29042501/plasmodium-falciparum-calcium-dependent-protein-kinase-2-is-critical-for-male-gametocyte-exflagellation-but-not-essential-for-asexual-proliferation
#18
Abhisheka Bansal, Alvaro Molina-Cruz, Joseph Brzostowski, Jianbing Mu, Louis H Miller
Drug development efforts have focused mostly on the asexual blood stages of the malaria parasite Plasmodium falciparum Except for primaquine, which has its own limitations, there are no available drugs that target the transmission of the parasite to mosquitoes. Therefore, there is a need to validate new parasite proteins that can be targeted for blocking transmission. P. falciparum calcium-dependent protein kinases (PfCDPKs) play critical roles at various stages of the parasite life cycle and, importantly, are absent in the human host...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29042387/nature-based-care-opportunities-and-barriers-in-oncology-contexts-a-modified-international-e-delphi-survey
#19
Sarah Blaschke, Clare C O'Callaghan, Penelope Schofield
OBJECTIVE: To develop recommendations regarding opportunities and barriers for nature-based care in oncology contexts using a structured knowledge generation process involving relevant healthcare and design experts. DESIGN: Four-round modified electronic Delphi study. Oncology patients' nature-based recommendations, uncovered in preceding qualitative investigation, were included in the first round for the expert participants' consideration. Key items (opportunities and barriers) were developed using data aggregation and synthesis, followed by item prioritisation and 10-point Likert scale ranking (1=not important, 10=very important)...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042266/development-and-validation-of-the-symptom-assessment-to-improve-symptom-control-for-institutionalized-elderly-scale
#20
Maaike L De Roo, Marc F Tanghe, Nele J Van Den Noortgate, Ruth D Piers
OBJECTIVES: To validate a newly developed multiple symptom self-assessment tool in nursing homes. DESIGN: Thirty prevalent symptoms identified in the literature were classified by a 2-round Delphi procedure to a top 10 of the most relevant, burdensome symptoms. Because no existing symptom scale fully covered this top 10, we developed a new scale, consisting of a horizontal numerical scale for the top 10 symptoms, with the possibility to add and rate 3 other symptoms...
October 14, 2017: Journal of the American Medical Directors Association
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