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https://www.readbyqxmd.com/read/29679895/ingredientes-farmac%C3%A3-uticos-activos-potencialmente-inapropiados-en-adultos-mayores-lista-ifaspiam-panel-de-consenso-argentino
#1
Marta M Marzi, Miryam S Pires, Nora B Quaglia
OBJECTIVES: To perform a list agreed by Argentinean experts and adapted to the local context containing potentially inappropriate (PI) medications in old people (OP) usingthe Delphi consensus technique optimized for this subject. METHODS: A preliminary list of potentially inappropriate medications (PIM) was drawn up based on foreign PIM lists and a selective search in the scientific literature. The iterative Delphi process was used to submit the active pharmaceutical ingredients (APIs) of the preliminary PIM list to the panel of Argentinean experts...
April 18, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29679551/histological-and-mechanical-evaluation-of-antifreeze-peptide-afp1m-cryopreserved-skin-grafts-post-transplantation-in-a-rat-model
#2
S M Ibrahim, O H Kareem, K M Saffanah, A A Adamu, M S Khan, M B A Rahman, M M Noordin, M Y Loqman
The objective of this study was to evaluate the use of Afp1m as a cryopreservative agent for skin by examining the transplanted skin histological architecture and mechanical properties following subzero cryopreservation. Thirty four (34) rats with an average weight of 208 ± 31 g (mean ± SD), were used. Twenty four (n = 24) rats were equally divided into four groups: (i) immediate non-cryopreserved skin autografts (onto same site), (ii) immediate non-cryopreserved skin autografts (onto different sites), (iii) skin autografts cryopreserved with glycerol for 72 h and (iv) skin autografts cryopreserved with Afp1m for 72 h at -4 °C...
April 18, 2018: Cryobiology
https://www.readbyqxmd.com/read/29679497/ewsr1-patz1-gene-fusion-may-define-a-new-glioneuronal-tumor-entity
#3
Aurore Siegfried, Audrey Rousseau, Claude-Alain Maurage, Sarah Pericart, Yvan Nicaise, Frederic Escudie, David Grand, Alix Delrieu, Anne Gomez-Brouchet, Sophie Le Guellec, Camille Franchet, Sergio Boetto, Matthieu Vinchon, Jean-Christophe Sol, Franck-Emmanuel Roux, Valerie Rigau, Anne-Isabelle Bertozzi, David Tw Jones, Dominique Figarella-Branger, Emmanuelle Uro-Coste
We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fusion panel. We did not retrieve the SLC44A1-PRKCA fusion gene specific for papillary glioneuronal tumor, but an EWSR1-PATZ1 fusion transcript. RT-PCR followed by Sanger sequencing confirmed the EWSR1-PATZ1 fusion. It matched with canonic EWSR1 fusion oncogene, juxtaposing the entire N terminal transcriptional activation domain of EWSR1 gene and the C terminal DNA binding domain of a transcription factor gene, PATZ1...
April 21, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29679494/risk-of-sun-induced-skin-cancers-in-patients-with-alopecia-areata-alopecia-totalis-and-alopecia-universalis
#4
Rosalynn R Z Conic, Rose Miller, Melissa Piliang, Wilma Bergfeld, Natasha Atanaskova Mesinkovska
Alopecia areata (AA) is an autoimmune non-scarring hair loss characterized by round patches on the scalp and body. It can progress to alopecia totalis (AT) where there is total loss of scalp hair and alopecia universalis (AU) in where hair loss encompasses the entire body. The pathophysiologic mechanism is unclear, but is thought to be due to peribulbar T-cell inflammation which results in premature induction of anagen follicles to catagen and telogen, without causing destruction of the hair follicle. This article is protected by copyright...
April 21, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29679409/increased-care-demand-and-medical-costs-after-falls-in-nursing-homes-a-delphi-study
#5
Carolyn Shanty Sterke, Martien J Panneman, Vicki Erasmus, Suzanne Polinder, Ed F van Beeck
AIMS AND OBJECTIVE: To estimate the increased care demand and medical costs caused by falls in nursing homes. BACKGROUND: There is compelling evidence that falls in nursing homes are preventable. However, proper implementation of evidence-based guidelines to prevent falls are often hindered by insufficient management support, staff time, and funding. DESIGN: A three-round Delphi study. METHODS: A panel of 41 experts, all working in nursing homes in the Netherlands, received three online questionnaires to estimate the extra hours of care needed during the first year after the fall...
April 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679219/rf-ablation-pattern-shaping-employing-switching-channels-of-dual-bipolar-needle-electrodes-ex-vivo-results
#6
Jens Ziegle, Chloé Audigier, Johannes Krug, Ghazanfar Ali, Younsu Kim, Emad M Boctor, Michael Friebe
PURPOSE: Radiofrequency (RF) ablation with mono- or bipolar electrodes is a common procedure for hepatocellular carcinoma (HCC) with a low rate of recurrence for small size tumors. For larger lesions and/or non-round/ellipsoid shapes RF ablation has some limitations and generally does not achieve comparable success rates to microwave ablation or high-intensity focused ultrasound therapies. MATERIALS AND METHODS: To shape RF ablations for matching a tumor size and geometry, we have developed an electronic channel switch box for two bipolar needles that generates multiple selectable ablation patterns...
April 20, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29679012/generalized-conditions-of-spherical-carbonate-concretion-formation-around-decaying-organic-matter-in-early-diagenesis
#7
Hidekazu Yoshida, Koshi Yamamoto, Masayo Minami, Nagayoshi Katsuta, Sirono Sin-Ichi, Richard Metcalfe
Isolated spherical carbonate concretions observed in marine sediments are fascinating natural objet trouve because of their rounded shapes and distinct sharp boundaries. They occur in varied matrices and often contain well preserved fossils. The formation process of such concretions has been explained by diffusion and rapid syn-depositional reactions with organic solutes and other pore water constituents. However, the rates, conditions and formation process of syngenetic spherical concretions are still not fully clear...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678829/draft-genome-sequence-of-camellia-sinensis-var-sinensis-provides-insights-into-the-evolution-of-the-tea-genome-and-tea-quality
#8
Chaoling Wei, Hua Yang, Songbo Wang, Jian Zhao, Chun Liu, Liping Gao, Enhua Xia, Ying Lu, Yuling Tai, Guangbiao She, Jun Sun, Haisheng Cao, Wei Tong, Qiang Gao, Yeyun Li, Weiwei Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, Congbing Fang, Yi Yue, Fangdong Li, Daxiang Li, Shu Wei, Bin Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Jeffrey L Bennetzen, Shancen Zhao, Xiaochun Wan
Tea, one of the world's most important beverage crops, provides numerous secondary metabolites that account for its rich taste and health benefits. Here we present a high-quality sequence of the genome of tea, Camellia sinensis var. sinensis (CSS), using both Illumina and PacBio sequencing technologies. At least 64% of the 3.1-Gb genome assembly consists of repetitive sequences, and the rest yields 33,932 high-confidence predictions of encoded proteins. Divergence between two major lineages, CSS and Camellia sinensis var...
April 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29678726/corticosterone-profiles-in-northern-cardinals-cardinalis-cardinalis-do-levels-vary-through-life-history-stages
#9
Benjamin M Duckworth, Jodie M Jawor
As animals move through life history stages, energy requirements for each stage will vary. Both daily and annual variation in the glucocoriticoid hormones (specifically corticosterone, or CORT, in birds) helps provide the variable energy needed through life history stages. In many bird species, CORT is higher in the breeding season when energy demands can be quite high and is often lower in the non-breeding season. Additionally, CORT has a role to play in the response to stressful stimuli and the level to which CORT is elevated following stressful events can vary through the annual cycle as well...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29678401/geographical-distribution-climate-adaptation-and-vector-competence-of-the-eurasian-hard-tick-haemaphysalis-concinna
#10
Franz Rubel, Katharina Brugger, Melanie Walter, Janna R Vogelgesang, Yuliya M Didyk, Su Fu, Olaf Kahl
The ixodid tick Haemaphysalis concinna Koch, 1844 is a proven vector of tick-borne encephalitis (TBE) virus and Francisella tularensis, the causative agent of tularaemia. In the present study, up-to-date maps depicting the geographical distribution and climate adaptation of H. concinna are presented. A dataset was compiled, resulting in 656 georeferenced locations in Eurasia. The distribution of H. concinna ranges from the Spanish Atlantic coast to Kamchatka, Russia, within the belt of 28-64° N latitude...
April 10, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29677447/prediction-models-for-assessing-lycopene-in-open-field-cultivated-tomatoes-by-means-of-a-portable-reflectance-sensor-cultivar-and-growing-season-effects
#11
Leonardo Ciaccheri, Lorenza Tuccio, Andrea A Mencaglia, Kalina Maja Sikorska-Zimny, Ewelina Hallmann, Artur Kowalski, Anna Grazia Mignani, Stanislaw Kaniszewski, Giovanni Agati
Reflectance spectroscopy represents a useful tool for the non-destructive assessment of tomato lycopene, even in the field. For this reason, a compact, low-cost, LED-based sensor has been developed to measure reflectance in the 400-750 nm spectral range. It was calibrated against wet chemistry and evaluated by Partial Least Squares (PLS) regression analyses. The lycopene prediction models were defined for two open-field cultivated red-tomato varieties: the processing oblong tomatoes of the cv. Calista (average weight: 76 g) and the fresh-consumption round tomatoes of the cv...
April 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29677184/elasticity-based-boosting-of-neuroepithelial-nucleokinesis-via-indirect-energy-transfer-from-mother-to-daughter
#12
Tomoyasu Shinoda, Arata Nagasaka, Yasuhiro Inoue, Ryo Higuchi, Yoshiaki Minami, Kagayaki Kato, Makoto Suzuki, Takefumi Kondo, Takumi Kawaue, Kanako Saito, Naoto Ueno, Yugo Fukazawa, Masaharu Nagayama, Takashi Miura, Taiji Adachi, Takaki Miyata
Neural progenitor cells (NPCs), which are apicobasally elongated and densely packed in the developing brain, systematically move their nuclei/somata in a cell cycle-dependent manner, called interkinetic nuclear migration (IKNM): apical during G2 and basal during G1. Although intracellular molecular mechanisms of individual IKNM have been explored, how heterogeneous IKNMs are collectively coordinated is unknown. Our quantitative cell-biological and in silico analyses revealed that tissue elasticity mechanically assists an initial step of basalward IKNM...
April 20, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29677152/optimization-of-the-critical-parameters-of-the-spherical-agglomeration-crystallization-method-by-the-application-of-the-quality-by-design-approach
#13
Orsolya Gyulai, Anita Kovács, Tamás Sovány, Ildikó Csóka, Zoltán Aigner
This research work presents the use of the Quality by Design (QbD) concept for optimization of the spherical agglomeration crystallization method in the case of the active agent, ambroxol hydrochloride (AMB HCl). AMB HCl spherical crystals were formulated by the spherical agglomeration method, which was applied as an antisolvent technique. Spherical crystals have good flowing properties, which makes the direct compression tableting method applicable. This means that the amount of additives used can be reduced and smaller tablets can be formed...
April 20, 2018: Materials
https://www.readbyqxmd.com/read/29676806/obstacles-to-comprehensive-dental-care-in-patients-with-sustained-limitations-of-their-decision-making-abilities-findings-from-a-delphi-study
#14
Alessandra Blaizot, Céline Catteau, Caroline Delfosse, Olivier Hamel, Thomas Trentesaux
The objective of this study was to explore the therapeutic limitations experienced by a panel of special-care dentists in France when treating patients with sustained limitations of their decision-making abilities. We used a Delphi technique conducted in three rounds from 01 June 2014 to 30 September 2015. A first questionnaire comprising open-ended questions was addressed to 72 panellists. A content analysis of the returned questionnaires served to draft a second questionnaire comprising closed-ended questions; this was sent to the 28 panellists who responded in the first round...
April 20, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29676370/primary-primitive-neuroectodermal-tumor-of-the-kidney
#15
Sunil Vitthalrao Jagtap, Pradnya Pandurang Kale, Anil Huddedar, Atul Bhanudas Hulwan, Swati S Jagtap
Renal primitive neuroectodermal tumor (PNET) is a rare entity. It should be differentiated from other primary renal malignancies. The differentiation of the malignant small round cell tumors may be challenging; however, it is essential for better management of the patient. We report a 45-year-old male having complaints of pain in the abdomen, hematuria, and mass in the abdomen for 6 months. Abdominal and pelvic sonography finding showed cystic-solid, right renal mass suggestive of malignancy. On histopathology diagnosed as malignant small round blue cell tumor suggestive of primitive neuroectodermal tumor...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676364/qualitative-defects-with-normal-sperm-counts-in-a-patient-attending-infertility-clinic
#16
Rachna Goyal, Mrinalini Kotru, Aarti Gogia, Sonal Sharma
Background: Sperm morphology is an important qualitative parameter in semen analysis. Aim: To assess qualitative defects in the semen with normal sperm counts. Setting and Design: This was a prospective and descriptive study done in a tertiary care center. Materials and Methods: Seventy-five semen samples with normal sperm counts were evaluated. Qualitative defects of sperms on Papanicolaou-stained slides were assessed. The defects were noted as follows: head (tapering head, large head, small head, round head, bifid head), middle piece (bent neck, broad middle piece, excess residual cytoplasm), and tail (coiled tail)...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676216/developing-a-compassionate-culture-within-pediatric-rehabilitation-does-the-schwartz-rounds%C3%A2-support-both-clinical-and-nonclinical-hospital-workers-in-managing-their-work-experiences
#17
Keith Adamson, Sonia Sengsavang, Sakeena Myers-Halbig, Nancy Searl
Schwartz Rounds™ offers an interprofessional forum for staff to openly engage in discussions about social-emotional aspects of care. We aimed to assess the perceived impact of Rounds in the health care context of pediatric rehabilitation, as well as a comparative analysis of how Rounds affected clinical versus nonclinical staff. Does effect on perceived outcomes was also investigated. Data were collected from 29 hospital staff (15 clinicians, 14 nonclinicians) who attended one, two, or three+ Rounds via semistructured interviews...
April 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29675629/-geriatric-trauma-center-dgu%C3%A2-evaluation-of-clinical-and-economic-parameters-a-pilot-study-in-a-german-university-hospital
#18
M Knobe, B Böttcher, M Coburn, T Friess, L C Bollheimer, H J Heppner, C J Werner, J-P Bach, M Wollgarten, S Poßelt, C Bliemel, B Bücking
BACKGROUND: Previous studies on orthogeriatric models of care suggest that there is substantial variability in how geriatric care is integrated in the patient management and the necessary intensity of geriatric involvement is questionable. OBJECTIVE: The aim of the current prospective cohort study was the clinical and economic evaluation of fragility fracture treatment pathways before and after the implementation of a geriatric trauma center in conformity with the guidelines of the German Trauma Society (DGU)...
April 19, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29675418/comparative-epidemiology-of-highly-pathogenic-avian-influenza-virus-h5n1-and-h5n6-in-vietnamese-live-bird-markets-spatiotemporal-patterns-of-distribution-and-risk-factors
#19
Kate C Mellor, Anne Meyer, Doaa A Elkholly, Guillaume Fournié, Pham T Long, Ken Inui, Pawin Padungtod, Marius Gilbert, Scott H Newman, Timothée Vergne, Dirk U Pfeiffer, Kim B Stevens
Highly pathogenic avian influenza (HPAI) H5N1 virus has been circulating in Vietnam since 2003, whilst outbreaks of HPAI H5N6 virus are more recent, having only been reported since 2014. Although the spatial distribution of H5N1 outbreaks and risk factors for virus occurrence has been extensively studied, there have been no comparative studies for H5N6. Data collected through active surveillance of Vietnamese live bird markets (LBMs) between 2011 and 2015 were used to explore and compare the spatiotemporal distributions of H5N1- and H5N6-positive LBMs...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29675142/reviewing-clinical-effectiveness-of-active-training-strategies-of-platform-based-ankle-rehabilitation-robots
#20
REVIEW
Xiangfeng Zeng, Guoli Zhu, Mingming Zhang, Sheng Q Xie
Objective: This review aims to provide a systematical investigation of clinical effectiveness of active training strategies applied in platform-based ankle robots. Method: English-language studies published from Jan 1980 to Aug 2017 were searched from four databases using key words of "Ankle∗ " AND "Robot∗ " AND "Effect∗ OR Improv∗ OR Increas∗ ." Following an initial screening, three rounds of discrimination were successively conducted based on the title, the abstract, and the full paper...
2018: Journal of Healthcare Engineering
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