Federico Salomone, Rosaria Maria Pipitone, Miriam Longo, Francesco Malvestiti, Angela Maria Amorini, Alfio Distefano, Elia Casirati, Ester Ciociola, Nunzio Iraci, Loredana Leggio, Rossella Zito, Nunzio Vicario, Concetta Saoca, Grazia Pennisi, Daniela Cabibi, Giuseppe Lazzarino, Anna Ludovica Fracanzani, Paola Dongiovanni, Luca Valenti, Salvatore Petta, Giovanni Li Volti, Stefania Grimaudo
BACKGROUND & AIMS: Sirtuin 5, encoded by the SIRT5 gene, is a NAD+ -dependent deacylase that modulates mitochondrial metabolic processes through post-translational modifications. In this study, we aimed to examine the impact of the SIRT5 rs12216101 T>G non-coding single nucleotide polymorphism on disease severity in patients with non-alcoholic fatty liver disease (NAFLD). METHODS: The rs12216101 variant was genotyped in 2,606 consecutive European patients with biopsy-proven NAFLD...
January 2024: Journal of Hepatology