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https://www.readbyqxmd.com/read/29787679/dynamic-proteome-alteration-and-functional-modulation-of-human-saliva-induced-by-dietary-chemosensory-stimuli
#1
Matthias Bader, Andreas Dunkel, Mareike Wenning, Bernd Kohler, Guillaume Medard, Estela Del Castillo, Amin Gholami, Bernhard Kuster, Siegfried Scherer, Thomas Hofmann
Saliva flow measurements and SDS-PAGE separation of human whole saliva freshly collected after oral stimulation with citric acid (sour), aspartame (sweet), iso-α-acids (bitter), mono sodium L-glutamate (umami), NaCl (salty), 6-gingerol (pungent), hydroxy-α-sanshool (tingling), and hydroxy-β-sanshool (numbing), followed by tryptic digestion, nano-HPLC-MS/MS, and label-free protein quantitation demonstrated a stimulus- and time-dependent influence of the dietary chemosensates on salivation and the salivary proteome composition...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29785679/drooling-in-parkinson-s-disease-evidence-of-a-role-for-divided-attention
#2
Hannah Reynolds, Nick Miller, Richard Walker
Drooling is a frequently reported symptom in Parkinson's Disease (PD) with significant psychosocial impact and negative health consequences including silent aspiration of saliva with the associated risk of respiratory infections. It is suggested that in PD drooling is associated with inefficient oropharyngeal swallowing which reduces the effective clearance of saliva rather than hyper-salivation. This is compounded by unintended mouth opening and flexed posture increasing anterior loss of saliva. It is reported to occur most frequently during cognitively distracting concurrent tasks suggesting an impact from divided attention in a dual-task situation...
May 21, 2018: Dysphagia
https://www.readbyqxmd.com/read/29783225/-features-of-exchange-of-calcium-saliva-in-patients-with-gastroesophageal-reflux-disease
#3
Mykola А Bychkov, Maryana М Yakhnitska
OBJECTIVE: Introduction: The pathogenesis of gastroesophageal reflux disease (GERD) is a topical issue of modern gastroenterology. There are a number of scientific papers on changes in the qualitative and quantitative composition of saliva, which triggers a cascade of biochemical reactions, the consequence of which is the destruction of the resistance of the mucous membrane of the esophagus. Calcium is a macro element that provides the normal functioning of cells. Parathormone also regulates the metabolism of calcium in the body...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29765136/detection-of-malaria-sporozoites-expelled-during-mosquito-sugar-feeding
#4
V A Brugman, M Kristan, M P Gibbins, F Angrisano, K A Sala, J T Dessens, A M Blagborough, T Walker
Malaria is a severe disease of global importance transmitted by mosquitoes of the genus Anopheles. The ability to rapidly detect the presence of infectious mosquitoes able to transmit malaria is of vital importance for surveillance, control and elimination efforts. Current methods principally rely on large-scale mosquito collections followed by labour-intensive salivary gland dissections or enzyme-linked immunosorbent (ELISA) methods to detect sporozoites. Using forced salivation, we demonstrate here that Anopheles mosquitoes infected with Plasmodium expel sporozoites during sugar feeding...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29755428/-culex-quinquefasciatus-diptera-culicidae-from-florida-transmitted-zika-virus
#5
Chelsea T Smartt, Dongyoung Shin, Seokyoung Kang, Walter J Tabachnick
We report a laboratory colony of Culex quinquefasciatus mosquitoes were experimentally able to salivate Zika virus (ZIKV, Flaviviridae; Flavivirus ) at 16 days post infection (dpi). ZIKV RNA was detected in bodies and in saliva deposited on filter paper cards with subsequent studies demonstrating the presence of live ZIKV in saliva.
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29754396/the-upper-pouch-in-oesophageal-atresia-shows-proportional-growth-during-late-fetal-life
#6
R B Tröbs, M Nissen, J Wald
Oesophageal atresia with trachea-oesophageal fistula is a rare foregut malformation that requires surgery soon after birth. Prenatal ultrasound diagnosis is based on the presence of polyhydramnios, a small or non-visible fetal stomach and the blind ending oesophagus, called the upper pouch (1). Neonates present with salivation, coughing, choking and attacks of cyanosis. A diagnosis of oesophageal atresia is confirmed by inserting a nasogastric tube and a thoraco-abdominal X-ray. This article is protected by copyright...
May 12, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29751100/low-level-laser-therapy-with-850-nm-recovers-salivary-function-via-membrane-redistribution-of-aquaporin-5-by-reducing-intracellular-ca-2-overload-and-er-stress-during-hyperglycemia
#7
Raktim Biswas, Jin Chul Ahn, Jeong Hwan Moon, Jungbin Kim, Young-Hoon Choi, So Young Park, Phil-Sang Chung
The overall goal is to study the effect of low-level laser therapy (LLLT) on membrane distribution of major water channel protein aquaporin 5 (AQP5) in salivary gland during hyperglycemia. Par C10 cells treated with high glucose (50 mM) showed a reduced membrane distribution of AQP5. The functional expression of AQP5 was down regulated due to intracellular Ca2+ overload and ER stress. This reduction in AQP5 expression impairs water permeability and therefore results in hypo-salivation. A reduced salivary flow was also observed in streptozotocin (STZ)-induced diabetic mice model and the expression of AQP5 and phospho-AQP5 was down regulated...
May 8, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29747836/multimorbidity-in-older-adults-with-cardiovascular-disease
#8
REVIEW
Daniel E Forman, Mathew S Maurer, Cynthia Boyd, Ralph Brindis, Marcel E Salive, Frances McFarland Horne, Susan P Bell, Terry Fulmer, David B Reuben, Susan Zieman, Michael W Rich
Multimorbidity occurs in adults of all ages, but the number and complexity of comorbid conditions commonly increase with advancing age such that cardiovascular disease (CVD) in older adults typically occurs in a context of multimorbidity. Current clinical practice and research mainly target single disease-specific care that does not embrace the complexities imposed by concurrent conditions. In this paper, emerging concepts regarding CVD in combination with multimorbidity are reviewed, including recommendations for incorporating multimorbidity into clinical decision making, critical knowledge gaps, and research priorities to optimize care of complex older patients...
May 15, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29741535/amanita-muscaria-fly-agaric-from-a-shamanistic-hallucinogen-to-the-search-for-acetylcholine
#9
M R Lee, E Dukan, I Milne
The mushroom Amanita muscaria (fly agaric) is widely distributed throughout continental Europe and the UK. Its common name suggests that it had been used to kill flies, until superseded by arsenic. The bioactive compounds occurring in the mushroom remained a mystery for long periods of time, but eventually four hallucinogens were isolated from the fungus: muscarine, muscimol, muscazone and ibotenic acid. The shamans of Eastern Siberia used the mushroom as an inebriant and a hallucinogen. In 1912, Henry Dale suggested that muscarine (or a closely related substance) was the transmitter at the parasympathetic nerve endings, where it would produce lacrimation, salivation, sweating, bronchoconstriction and increased intestinal motility...
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29736103/effectiveness-of-manual-treatment-on-pregnancy-symptoms-usefulness-of-manual-treatment-in-treating-pregnancy-symptoms
#10
Boris Skarica
Objectives: To determine the usefulness of manual treatment in reducing or eliminating pregnancy symptoms during first and second trimester. Methods: Manual treatment of the cervical and thoracic spine was performed in a group of 115 pregnant women who developed pregnancy symptoms during normal pregnancy. A rotational traction of the cervical spine was applied. Patients in whom the treatment was unsuccessful underwent second round of treatment after a pause of a minimum 3 days...
April 2018: Medical Archives
https://www.readbyqxmd.com/read/29690969/molecular-pathogenesis-of-chewable-tobacco
#11
Saeeda Baig, Zile Rubab, Wasfa Farooq
In Pakistan, extensive use of several precarious chewable tobacco formulations has made oral cancer the second leading malignancy. Selection of literature was done by a survey of studies published from 1990 to 2017 mainly, from PUBMED and few from other search engines, on naswar, gutka, areca nut and betel quid, which included published reviews, original articles and other data sources on chewable tobacco, its epidemiology, pathological implications, and psychological effects. These studies have revealed that the chemicals in these formulations bind and mutate DNA of oral mucosa through down regulating cellular repair pathways and upregulating genetic networks associated with pathogenesis...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29670741/coexisting-sublingual-dermoid-cyst-and-heterotopic-gastrointestinal-cyst-case-report
#12
Göksel Şimşek-Kaya, İrem-Hicran Özbudak, Dinçer Kader
A heterotopic oral gastrointestinal cyst coexisting with a lingual dermoid cyst is a rare condition, with only 3 reported cases in the English-language literature. Clinically, both gastrointestinal and dermoid cysts tend to manifest as an asymptomatic swelling. Cysts above the mylohyoid often present with sublingual swelling, whereas those below the mylohyoid present with submental swelling. Increased salivation, altered speech, dyspnea and difficulties in eating, swallowing and respiration may be present, depending on the size of the cyst...
February 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29664367/epizootic-hemorrhagic-disease-virus-serotype-6-infection-in-cattle-japan-2015
#13
Yuka Kamomae, Masahiro Kamomae, Yasuyuki Ohta, Mikoto Nabe, Yuichi Kagawa, Yuji Ogura, Tomoko Kato, Shogo Tanaka, Tohru Yanase, Hiroaki Shirafuji
During October-December 2015, an epizootic hemorrhagic disease outbreak occurred in cattle in Japan. Forty-six animals displayed fever, anorexia, cessation of rumination, salivation, and dysphagia. Virologic, serologic, and pathologic investigations revealed the causative agent was epizootic hemorrhagic disease virus serotype 6. Further virus characterization is needed to determine virus pathogenicity.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29652888/sialome-diversity-of-ticks-revealed-by-rnaseq-of-single-tick-salivary-glands
#14
Jan Perner, Sára Kropáčková, Petr Kopáček, José M C Ribeiro
Ticks salivate while feeding on their hosts. Saliva helps blood feeding through host anti-hemostatic and immunomodulatory components. Previous transcriptomic and proteomic studies revealed the complexity of tick saliva, comprising hundreds of polypeptides grouped in several multi-genic families such as lipocalins, Kunitz-domain containing peptides, metalloproteases, basic tail secreted proteins, and several other families uniquely found in ticks. These studies also revealed that the composition of saliva changes with time; expression of transcripts from the same family wax and wane as a function of feeding time...
April 13, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29628621/behavioral-plasticity-in-probing-by-diaphorina-citri-hemiptera-liviidae-ingestion-from-phloem-versus-xylem-is-influenced-by-leaf-age-and-surface
#15
Timothy A Ebert, Elaine A Backus, Holly J Shugart, Michael E Rogers
Diaphorina citri is a major pest of citrus because it transmits Candidatus Liberibacter asiaticus, a phloem-limited bacterium that putatively causes Huanglongbing (HLB). The disease moves slowly through a tree, and the vector facilitates further within-tree movement via transmission of the pathogen. However, this only happens when D. citri stylets contact the phloem, to inoculate bacteria during phloem salivation and acquire bacteria during phloem sap ingestion. Behavioral changes in D. citri associated with different plant parts would affect how long it takes to reach phloem and how long the psyllids stays in phloem to ingest, thereby influencing the risk of disease spread...
2018: Journal of Insect Behavior
https://www.readbyqxmd.com/read/29628453/multiple-acquired-portosystemic-shunts-secondary-to-primary-hypoplasia-of-the-portal-vein-in-a-cat
#16
Satoko Sugimoto, Shingo Maeda, Masaya Tsuboi, Kohei Saeki, James K Chambers, Tomohiro Yonezawa, Kenjiro Fukushima, Reina Fujiwara, Kazuyuki Uchida, Hajime Tsujimoto, Naoaki Matsuki, Koichi Ohno
A 6-year 5-month-old spayed female Scottish Fold cat presented with a one-month history of gait abnormalities, increased salivation, and decreased activity. A blood test showed hyperammonemia and increased serum bile acids. Imaging tests revealed multiple shunt vessels indicating acquired portosystemic shunt. Histopathologic analysis of liver biopsy showed features consistent with liver hypoperfusion, such as a barely recognizable portal vein, increased numbers of small arterioles, and diffuse vacuolar degeneration of hepatocytes...
April 9, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29618907/green-tobacco-sickness-a-brief-review
#17
REVIEW
Shailee Fotedar, Vikas Fotedar
Green tobacco sickness (GTS) is the condition that mainly affects the tobacco harvesters. The condition is prevalent in Asian and South American tobacco harvesters. The present review was conducted to discuss the etiology, epidemiology, symptoms, and prevention of GTS. It is caused by the absorption of nicotine through the skin while the workers are engaged in handling the uncured tobacco leaves. The symptoms include nausea, vomiting, pallor, dizziness, headaches, increased perspiration, chills, abdominal pain, diarrhea, increased salivation, prostration, weakness, breathlessness, and occasional lowering of blood pressure...
September 2017: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29616878/integrating-competing-demands-of-osmoregulatory-and-thermoregulatory-homeostasis
#18
Michael J McKinley, Davide Martelli, Glenn L Pennington, David Trevaks, Robin M McAllen
Mammals are characterized by a stable core body temperature. When maintenance of core temperature is challenged by ambient or internal heat loads, mammals increase blood flow to the skin, sweat and/or pant, or salivate. These thermoregulatory responses enable evaporative cooling at moist surfaces to dissipate body heat. If water losses incurred during evaporative cooling are not replaced, body fluid homeostasis is challenged. This article reviews the way mammals balance thermoregulation and osmoregulation.
May 1, 2018: Physiology
https://www.readbyqxmd.com/read/29577526/the-assessment-of-bulbar-function-in-amyotrophic-lateral-sclerosis-validation-of-a-self-report-scale-cns-bfs
#19
Richard A Smith, Eric A Macklin, Kathleen J Myers, Gary L Pattee, Kimberly L Goslin, Gregg D Meekins, Jordan R Green, Jeremy M Shefner, Erik P Pioro
BACKGROUND: Impaired bulbar functions of speech and swallowing are among the most serious consequences of amyotrophic lateral sclerosis (ALS). Despite this, clinical trials in ALS have rarely emphasized bulbar function as an endpoint. When symptomatic benefit is measured, the rater-administered ALSFRS-R functional rating scale or various quality of life measures are commonly used. Accordingly, we sought to evaluate the utility of measures specific to bulbar function in ALS. METHODS: We assessed bulbar functions in 120 ALS patients, with clinicians first making direct observations of the degree of speech, swallowing, and salivation impairment in these subjects...
March 25, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29561383/taste-changes-in-patients-with-middle-ear-surgery-by-intraoperative-manipulation-of-chorda-tympani-nerve
#20
Nayeon Choi, Jungmin Ahn, Yang-Sun Cho
OBJECTIVES: The aim of study was to evaluate the subjective changes of taste and salivation after middle ear surgery according to chorda tympani nerve (CTN) injury. STUDY DESIGN: Prospective cohort study. SETTING: Tertiary referral center. PATIENTS: We enrolled 180 patients older than 13 years old who received middle ear surgery. INTERVENTIONS: The patients were classified into cut, manipulated, and intact groups according to intraoperative assessments of the CTN...
March 20, 2018: Otology & Neurotology
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