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https://www.readbyqxmd.com/read/28220985/the-head-and-neck-cancer-patient-concern-inventory-%C3%A2-patient-concerns-prevalence-dental-concerns-impact-and-relationships-of-concerns-with-quality-of-life-measures
#1
Maria L Aguilar, Pamela Sandow, John W Werning, Lia Brenneman, Walter J Psoter
PURPOSE: The Patient Concern Inventory(©) (PCI) is a clinical tool of self-reported patient concerns to be used by the clinician to structure the patient-oncologist visit. It was developed in the United Kingdom to address the issues of quality of life (QOL) in head and neck cancer (HNC) patients. The purpose of the study reported here was to determine the prevalence of PCI(©) items, the associations between PCI(©) items and QOL, and to explore the importance of oral/dental issues in the patient's well-being...
February 21, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28215815/influence-of-tramadol-on-acute-thermal-and-mechanical-cutaneous-nociception-in-dogs
#2
Alexandra F Schütter, Julia Tünsmeyer, Sabine B R Kästner
OBJECTIVE: The aim of the study was to evaluate the influence of tramadol on acute nociception in dogs. STUDY DESIGN: Experimental, blinded, randomized, crossover study. ANIMALS: Six healthy laboratory Beagle dogs. METHODS: Dogs received three treatments intravenously (IV): isotonic saline placebo (P), tramadol 1 mg kg(-1) (T1) and tramadol 4 mg kg(-1) (T4). Thermal thresholds were determined by ramped contact heat stimulation (0...
January 7, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28213963/ultrastructure-of-compatible-and-incompatible-interactions-in-phloem-sieve-elements-during-the-stylet-penetration-by-cotton-aphids-in-melon
#3
Elisa Garzo, Mercedes Fernández-Pascual, Cesar Morcillo, Alberto Fereres, M Luisa Gómez-Guillamón, W Fred Tjallingii
Resistance of the melon line TGR-1551 to the aphid Aphis gossypii is based on preventing aphids from ingesting phloem sap. In electrical penetration graphs (EPGs), this resistance has been characterized with A. gossypii showing unusually long phloem salivation periods (waveform E1) mostly followed by pathway activities (waveform C) or if followed by phloem ingestion (waveform E2), ingestion was not sustained for more than 10 minutes. Stylectomy with aphids on susceptible and resistant plants was performed during EPG recording while the stylet tips were phloem inserted...
February 18, 2017: Insect Science
https://www.readbyqxmd.com/read/28210931/serotonin-syndrome-from-5-hydroxytryptophan-supplement-ingestion-in-a-9-month-old-labrador-retriever
#4
Hopkins Jennifer, Pardo Mariana, Bischoff Karyn
INTRODUCTION: 5-Hydroxytryptophan (5-HTP) supplements are available over the counter and labeled as sleeping aids and anxiolytics for human use. 5-HTP is a serotonin precursor and overdose can lead to serotonin syndrome. CASE REPORT: A 9-month-old female Labrador retriever was evaluated after ingestion of a 5-HTP supplement. Signs of agitation developed within 1 h of ingestion, and emesis was attempted by the owner with  3% hydrogen peroxide (H2O2) orally. On presentation, the dog was obtunded, bilaterally mydriatic and salivating...
February 16, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28177730/impaired-mitochondria-and-intracellular-calcium-transients-in-the-salivary-glands-of-obese-rats
#5
Jitjiroj Ittichaicharoen, Nattayaporn Apaijai, Pongpan Tanajak, Piangkwan Sa-Nguanmoo, Nipon Chattipakorn, Siriporn C Chattipakorn
PURPOSE: Long-term consumption of a high-fat diet (HFD) causes not only obese-insulin resistance, but is also associated with mitochondrial dysfunction in several organs. However, the effect of obese-insulin resistance on salivary glands has not been investigated. We hypothesized that obese-insulin resistance induced by HFD impaired salivary gland function by reducing salivation, increasing inflammation and fibrosis, as well as impairing mitochondrial function and calcium transient signaling...
December 21, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28162846/ketamine-xylazine-anaesthesia-and-orofacial-administration-of-substance-p-a-lethal-combination-in-rats
#6
Janetti N Francischi, Taíssa Iolanda C Frade, Marcella P A de Almeida, Bárbara F G de Queiroz, Y S Bakhle
BACKGROUND AND AIMS: Ketamine+xylazine mixture is a widely used anaesthetic in animal experiments. In rats anaesthetized with this mixture, we have shown that injection of carrageenan, a standard proinflammatory stimulus, into the cheek (intra-oral injection) induced oedema. A likely mediator of this oedema is substance P (SP), a major transmitter of sensory nerves in orofacial tissue. We have assessed the effects of intra-oral injection of SP in rats. EXPERIMENTAL APPROACH: SP (50-1μg per rat) was injected intra-orally in male adult Holtzman or Wistar rats, anaesthetized with ketamine+xylazine...
January 23, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28160523/orofacial-functions-in-experimental-models-of-cerebral-palsy-a-systematic-review
#7
REVIEW
Diego Cabral Lacerda, Kelli Nogueira Ferraz-Pereira, André Terácio, Bárbara Juacy Rodrigues Costa de Santana, Omar Guzman Quevedo, Raul Manhães-de-Castro, Ana Elisa Toscano
BACKGROUND: Children who suffer from cerebral palsy (CP) often present comorbidities in the form of orofacial dysfunctions. Studies in animals have contributed to elaborate potential therapies aimed at minimizing the chronic disability of the syndrome. OBJECTIVE: To systematically review the scientific literature regarding the possible effects that experimental models of CP can have on orofacial functions. METHODS: Two independent authors conducted a systematic review in the electronic databases Medline, Scopus, CINAHL, Web of Science and Lilacs, using Mesh and Decs terms in animal models...
February 4, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28150091/reliability-and-validity-of-the-short-version-of-udvalg-for-kliniske-undersogelser-in-antipsychotic-treatment
#8
Kun-Po Chen, For-Wey Lung
The aim of this study was to develop a reliable and valid short version of the Udvalg for Kliniske Undersogelser (UKU) to efficiently evaluate the side effects of antipsychotics in patients with schizophrenia. This multi-site study included 10 hospitals, which included 331 inpatients and outpatients diagnosed with schizophrenia. UKU, Clinical Global Impression-Severity (CGI-S), Personal and Social Performance (PSP) and dosage of paliperidone were collected. The predictive validity of the UKU-short version, as well as that of the CGI-S, PSP and paliperidone dosages, was analyzed using structural equation modeling (SEM), latent growth models (LGM), and confirmatory factor analysis to test its content and construct validity...
February 1, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28133509/subchronic-oral-toxicity-study-of-acanthopanax-divaricatus-var-albeofructus-in-rats
#9
Myoung Jun Kim, Mi Ju Lee, Yong-Hoon Lee, Sun Hee Park, Duyeol Kim, Cheol Beom Park, Jin Seok Kang, Jong-Koo Kang
Acanthopanax divaricatus (Siebold & Zucc.) Seem. var. albeofructus (ADA), a traditional medical herb, has been used to treat arthritis and muscular injury, to strengthen muscle and bone, and to get vital energy. However, information regarding its toxicity is limited. ADA was administered by oral gavage to groups of rats at doses of 0 (control), 1,000, 1,500, 2,000, 2,500, and 3,000 mg/kg five times per week for 13 weeks. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, urinalysis, organ weights, necropsy, histopathological finding, vaginal cytology, and sperm morphology were compared between control and ADA-treated groups...
January 2017: Toxicological Research
https://www.readbyqxmd.com/read/28130146/first-finding-of-a-dual-meaning-x-wave-for-phloem-and-xylem-fluid-ingestion-characterization-of-scaphoideus-titanus-hemiptera-cicadellidae-epg-waveforms
#10
Julien Chuche, Elaine A Backus, Denis Thiery, Nicolas Sauvion
The leafhopper Scaphoideus titanus (Hemiptera: Cicadomorpha: Cicadellidae), an invasive deltocephaline species introduced into Europe from North America, is the vector of the most important phytoplasma disease in European viticulture, flavescence dorée. In this first electropenetrography (EPG) study of S. titanus, we characterized its feeding waveforms and defined their biological meanings. Four typical waveform phases (pathway, X wave, sustained ingestion, and interruption) and four families within those phases (A, B, C, and N) were characterized using DC EPG technology...
January 24, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28118925/treatment-of-the-first-bite-syndrome
#11
María Costales-Marcos, Fernando López Álvarez, Laura Fernández-Vañes, Justo Gómez, José Luis Llorente
First bite syndrome is a potential complication of surgery involving the infratemporal fossa, deep lobe of the parotid gland and parapharyngeal space. It is described as an acute and intense pain in the parotid region caused with the first bite of each meal. It is related to damage to sympathetic innervation of the parotid gland. Parasympathetic hyperactivation is believed to stimulate an exaggerated myoepithelial cell contraction causing pain. Usual analgesic treatments have poor results. Botulinum toxin type A causes parasympathetic nerve paralysis of the parotid gland and this fact would minimize salivation and decrease first bite syndrome...
January 21, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28118553/endothelial-tight-junctions-are-opened-in-cholinergic-evoked-salivation-in-vivo
#12
X Cong, Y Zhang, Q H He, T Wei, X M Zhang, J Z Zhang, R L Xiang, G Y Yu, L L Wu
Blood vessels provide the original supplies for the formation of primary saliva, which is regulated by the tight junctions (TJs) between endothelial cells. Previous studies have shown that blood flow increases with vasodilatation during cholinergic-evoked salivation. However, changes in vascular paracellular permeability and the role of endothelial TJs in salivation are unknown. Here, we established an in vivo paracellular permeability detection system and observed that the endothelial TJs were permeable to 4-kDa fluorescein isothiocyanate (FITC)-dextran while impermeable to 40- and 70-kDa FITC-dextran under an unstimulated condition in mouse submandibular glands (SMGs)...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28111131/contagious-caprine-pleuropneumonia-the-first-isolation-and-molecular-characterization-of-mycoplasma-capricolum-subsp-capripneumoniae-in-the-kingdom-of-saudi-arabia
#13
Wael El-Deeb, Abdul Aziz Almujalli, Isam Eljalii, Ahmed Elmoslemany, Mahmoud Fayez
Classical contagious caprine pleuropneumonia is one of the most fatal contagious disease of goats listed by World Organization for Animal Health that leads to major economic losses. It is caused by infection with Mycoplasma capricolum subspecies capripneumoniae. In order to isolate the causative agents of CCPP for the first time in the Kingdom of Saudi Arabia, fifteen flocks from Eastern region (Al Ahsa, Dammam and Hafr Albaten) and ten flocks from Riyadh and Al-Kharj regions were selected for this study. A total of 700 samples (400 nasal swabs, 300 pleural fluid samples and lung samples (from necropsied animals)) were collected from goats showing typical signs of CCPP...
January 19, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28098749/a-semipersistent-plant-virus-differentially-manipulates-feeding-behaviors-of-different-sexes-and-biotypes-of-its-whitefly-vector
#14
Shaohua Lu, Jingjing Li, Xueli Wang, Danyang Song, Rune Bai, Yan Shi, Qinsheng Gu, Yen-Wen Kuo, Bryce W Falk, Fengming Yan
It is known that plant viruses can change the performance of their vectors. However, there have been no reports on whether or how a semipersistent plant virus manipulates the feeding behaviors of its whitefly vectors. Cucurbit chlorotic yellows virus (CCYV) (genus Crinivirus, family Closteroviridae) is an emergent plant virus in many Asian countries and is transmitted specifically by B and Q biotypes of tobacco whitefly, Bemisia tabaci (Gennadius), in a semipersistent manner. In the present study, we used electrical penetration graph (EPG) technique to investigate the effect of CCYV on the feeding behaviors of B...
January 13, 2017: Viruses
https://www.readbyqxmd.com/read/28070747/enhanced-bulbar-function-in-amyotrophic-lateral-sclerosis-the-nuedexta-treatment-trial
#15
Richard Smith, Erik Pioro, Kathleen Myers, Michael Sirdofsky, Kimberly Goslin, Gregg Meekins, Hong Yu, James Wymer, Merit Cudkowicz, Eric A Macklin, David Schoenfeld, Gary Pattee
The goal of this randomized, blinded, crossover clinical trial was to determine whether Nuedexta (dextromethorphan and quinidine) enhanced speech, swallowing, and salivation in patients with ALS. Sixty patients with amyotrophic lateral sclerosis (ALS) received either Nuedexta or placebo for 28 to 30 days, followed by a 10 to 15-day washout period. Subsequently, patients were switched to the opposite treatment arm for the remaining days of the trial. The primary endpoint was a reduction in the self-report Center for Neurologic Study Bulbar Function Scale (CNS-BFS) score...
January 9, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28056951/capromorelin-oral-solution-entyce%C3%A2-increases-food-consumption-and-body-weight-when-administered-for-4-consecutive-days-to-healthy-adult-beagle-dogs-in-a-randomized-masked-placebo-controlled-study
#16
RANDOMIZED CONTROLLED TRIAL
Bill Zollers, Linda Rhodes, Ernst Heinen
BACKGROUND: Dogs can suffer from inappetence caused by a variety of medical conditions. This may present as anorexia (complete loss of appetite), hyporexia (decreased appetite) or dysrexia (change in food preferences). A drug with a new mechanism of action, capromorelin, has potential to stimulate appetite in dogs. Capromorelin is a ghrelin receptor agonist, which mimics the action of endogenous ghrelin. It is a member of the growth hormone secretagogue (GHS) class of drugs. Capromorelin oral solution (ENTYCE®) was tested in healthy adult male and female Beagle dogs (n = 6 males and 6 females per group) for its effect on food consumption and body weight...
January 5, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28039132/a-plant-bacterial-pathogen-manipulates-its-insect-vector-s-energy-metabolism
#17
Nabil Killiny, Faraj Hijaz, Timothy A Ebert, Michael E Rogers
Insect-transmitted plant-pathogenic bacteria may alter their vectors' fitness, survival, behavior, and metabolism. Because these pathogens interact with their vectors on the cellular and organismal levels, potential changes at the biochemical level might occur. "Candidatus Liberibacter asiaticus" (CLas) is transmitted in a persistent, circulative, and propagative manner. The genome of CLas revealed the presence of an ATP translocase that mediates the uptake of ATP and other nucleotides from medium to achieve its biological processes, such as growth and multiplication...
March 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28025847/metabolic-remodeling-triggered-by-salivation-and-diabetes-in-major-salivary-glands
#18
Fernando N Nogueira, Rui A Carvalho
The metabolic profile of major salivary glands was evaluated by (13) C nuclear magnetic resonance isotopomer analysis ((13) C NMR-IA) following the infusion of [U-(13) C]glucose in order to define the true metabolic character of submandibular (SM) and parotid (PA) glands at rest and during salivary stimulation, and to determine the metabolic remodeling driven by diabetes. In healthy conditions, the SM gland is characterized at rest by a glycolytic metabolic profile and extensive pyruvate cycling. On the contrary, the PA gland, although also dominated by glycolysis, also possesses significant Krebs' cycle activity and does not sustain extensive pyruvate cycling...
December 26, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/28018405/modulation-of-legume-defense-signaling-pathways-by-native-and-non-native-pea-aphid-clones
#19
Carlos Sanchez-Arcos, Michael Reichelt, Jonathan Gershenzon, Grit Kunert
The pea aphid (Acyrthosiphon pisum) is a complex of at least 15 genetically different host races that are native to specific legume plants, but can all develop on the universal host plant Vicia faba. Despite much research, it is still unclear why pea aphid host races (biotypes) are able to colonize their native hosts while other host races are not. All aphids penetrate the plant and salivate into plant cells when they test plant suitability. Thus plants might react differently to the various pea aphid host races...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27990759/the-toxicity-of-flonicamid-to-cotton-leafhopper-amrasca-biguttula-ishida-is-by-disruption-of-ingestion-an-epg-study
#20
Kaleem Tariq, Mah Noor, Elaine A Backus, Adil Hussain, Asad Ali, Wei Peng, Hongyu Zhang
BACKGROUND: The cotton leafhopper, Amrasca biguttula, is one of the most destructive pests of cotton in Asia. This species is thought to cause damage by injecting enzymatic saliva into various, presently unknown, cotton tissues and ingesting the resulting macerate. Flonicamid is a novel systemic insecticide used to control the cotton leafhopper however, its mode of action is unknown. RESULTS: The mechanism of action of flonicamid on cotton leafhopper was investigated using electropenetrography (EPG)...
December 19, 2016: Pest Management Science
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