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https://www.readbyqxmd.com/read/29226820/furosemide-reimagined-novel-subcutaneous-formulation-for-a-50-year-old-loop-diuretic-agent-for-the-treatment-of-acute-decompensated-heart%C3%A2-failure
#1
EDITORIAL
Gary S Francis, Tamas Alexy
No abstract text is available yet for this article.
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226816/efficacy-of-intravenous-furosemide-versus%C3%A2-a-novel-ph-neutral-furosemide-formulation-administered-subcutaneously%C3%A2-in-outpatients-with-worsening-heart%C3%A2-failure
#2
Nisha A Gilotra, Oluseyi Princewill, Bonnie Marino, Ike S Okwuosa, Jessica Chasler, Johana Almansa, Abby Cummings, Parker Rhodes, Julianne Chambers, Kimberly Cuomo, Stuart D Russell
OBJECTIVES: This study sought to determine the efficacy and safety of a novel, pH-neutral formulation of furosemide administered subcutaneously (SC) for treatment of acute decompensated heart failure (HF). BACKGROUND: Congestion requiring intravenous (IV) administration of a diuretic agent is the main reason patients with HF present for acute medical care. METHODS: Outpatients presenting with decompensated HF were randomized to receive a single SC or IV dose of furosemide...
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226589/hydrochlorothiazide-and-acute-urinary-acidification-the-voltage-hypothesis-of-enac-dependent-h-secretion-refuted
#3
Niklas Ayasse, Pauline I A de Bruijn, Peder Berg, Mads V Sørensen, Jens Leipziger
AIM: The 'voltage hypothesis' of H+ secretion states that urinary acidification following increased Na+ delivery to the collecting duct (CD) is ENaC-dependent leading to transepithelial voltage-dependent increase in H+ secretion. We recently showed that furosemide acidifies the urine independently of ENaC activity. If the voltage hypothesis holds, hydrochlorothiazide (HCT) must acidify the urine. We here tested the acute effect of HCT on urine pH under normal and high ENaC expression...
December 11, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29223725/transfusion-associated-circulatory-overload-a-survey-among-dutch-intensive-care-fellows
#4
R B Klanderman, I Attaye, J J Bosboom, D P Veelo, B F Geerts, A P J Vlaar
OBJECTIVES: Transfusion-associated circulatory overload (TACO) is a severe pulmonary transfusion reaction and leading cause of transfusion-related morbidity and mortality in Europe. TACO is of particular importance in critically ill patients, since they often receive blood transfusions and have multiple risk factors for TACO. This study investigates transfusion practices in patients at risk of developing TACO, and furthermore knowledge concerning risk factors, diagnoses and treatment strategies among Dutch intensive care unit (ICU) fellows...
December 6, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29223430/rational-and-design-of-a-randomized-double-blind-multicenter-trial-to-evaluate-the-safety-and-tolerability-of-furosemide-withdrawal-in-stable-chronic-outpatients-with-heart-failure-the-rebic-1-trial
#5
Priscila Raupp da Rosa, Luis E Rohde, Madeni Doebber, Antonio L P Ribeiro, Deborah P Prado, Eduardo G Bertoldi, Jose A Figueiredo Neto, Ilmar Kohler, Luis Beck-da-Silva, Luiz C Danzmann, Lidia Zytynski Moura, Marciane Rover, Marcus V Simões, Roberto T Sant'Anna, Andréia Biolo
AIMS: Furosemide is commonly prescribed for symptom relief in heart failure (HF) patients. Although few data support the continuous use of loop diuretics in apparently euvolemic HF patients with mild symptoms, there is concern about safety of diuretic withdrawal in these patients. The ReBIC-1 trial was designed to evaluate the safety and tolerability of withdrawing furosemide in stable, euvolemic, chronic HF outpatients. This multicenter initiative is part of the Brazilian Research Network in Heart Failure (ReBIC) created to develop clinical studies in HF and composed predominantly by university tertiary care hospitals...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29212860/reference-values-of-renal-tubular-function-tests-are-dependent-on-age-and-kidney-function
#6
Anneke P Bech, Jack F M Wetzels, Tom Nijenhuis
Electrolyte disorders due to tubular disorders are rare, and knowledge about validated clinical diagnostic tools such as tubular function tests is sparse. Reference values for tubular function tests are based on studies with small sample size in young healthy volunteers. Patients with tubular disorders, however, frequently are older and can have a compromised renal function. We therefore evaluated four tubular function tests in individuals with different ages and renal function. We performed furosemide, thiazide, furosemide-fludrocortisone, and desmopressin tests in healthy individuals aged 18-50 years, healthy individuals aged more than 50 years and individuals with compromised renal function...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29212491/case-report-schwannoma-arising-from-the-unilateral-adrenal-area-with-bilateral-hyperaldosteronism
#7
Naru Babaya, Yukako Makutani, Shinsuke Noso, Yoshihisa Hiromine, Hiroyuki Ito, Yasunori Taketomo, Kazuki Ueda, Hokuto Ushijima, Yoshifumi Komoike, Yuto Yamazaki, Hironobu Sasano, Yumiko Kawabata, Hiroshi Ikegami
BACKGROUND: We report a rare case of a juxta-adrenal schwannoma that could not be discriminated from an adrenal tumor before surgical resection and was complicated by bilateral hyperaldosteronism. To the best of our knowledge, this is first case in which both a juxta-adrenal schwannoma and hyperaldosteronism co-existed. CASE PRESENTATION: A 69-year-old male treated for hypertension was found to have a left supra-renal mass (5.8 × 5.2 cm) by abdominal computed tomography...
December 6, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29202387/successive-ratio-subtraction-as-a-novel-manipulation-of-ratio-spectra-for-quantitative-determination-of-a-mixture-of-furosemide-spironolactone-and-canrenone
#8
Aml A Emam, Eglal A Abdelaleem, Ibrahim A Naguib, Fatma F Abdallah, Nouruddin W Ali
Furosemide and spironolactone are commonly prescribed antihypertensive drugs. Canrenone is the main degradation product and main metabolite of spironolactone. Ratio subtraction and extended ratio subtraction spectrophotometric methods were previously applied for quantitation of only binary mixtures. An extension of the above mentioned methods; successive ratio subtraction, is introduced in the presented work for quantitative determination of ternary mixtures exemplified by furosemide, spironolactone and canrenone...
December 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29197870/detection-of-acute-tubular-necrosis-using-blood-oxygenation-level-dependent-bold-mri
#9
Frederic Bauer, Jan Wald, Felix Jan Bauer, Lisa Maria Dahlkamp, Felix S Seibert, Nikolaos Pagonas, Egbert Gedat, Nina Babel, Walter Zidek, Christian von Bodman, Joachim Noldus, Dieter Liermann, Timm H Westhoff
BACKGROUND/AIMS: To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tubule-specific pharmacological maneuver. METHODS: Cross sectional study with 28 participants including 9 subjects with ATN-induced acute kidney injury (AKI), 9 healthy controls, and 10 subjects with nephron sparing tumor resection (NSS) with clamping of the renal artery serving as a model of ischemia/reperfusion (I/R)-induced subclinical ATN (median clamping time 15 min, no significant decrease of eGFR, p=0...
December 4, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29196838/inverse-correlation-between-left-ventricular-end-diastolic-pressure-and-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#10
Guoqiang Gu, Hanghang Xing, Yaqing Zhou, Wei Cui
BACKGROUND: There is a rising incidence of contrast-induced nephropathy (CIN), which is defined as either a 25% relative increase or an absolute increase of 0.5 mg/dL (44.2 µmol/L) in the serum creatinine (Scr) level at 48-72 h after administration of iodinated contrast media (CM). We investigated the relationship between left ventricular end-diastolic pressure (LVEDP) and CIN in patients undergoing percutaneous coronary intervention (PCI). METHODS: A total of 431 consecutive patients with coronary artery disease undergoing PCI were divided into four groups based on LVEDP quartile cut-off points...
December 1, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29192005/successful-reversal-of-furosemide-induced-secondary-hyperparathyroidism-with-cinacalcet
#11
Tarak Srivastava, Shahryar Jafri, William E Truog, Judith Sebestyen VanSickle, Winston M Manimtim, Uri S Alon
Secondary hyperparathyroidism (SHPT) is a rare complication of furosemide therapy that can occur in patients treated with the loop diuretic for a long period of time. We report a 6-month-old 28-weeks premature infant treated chronically with furosemide for his bronchopulmonary dysplasia, who developed hypocalcemia and severe SHPT, adversely affecting his bones. Discontinuation of the loop diuretic and the addition of supplemental calcium and calcitriol only partially reversed the SHPT, bringing serum parathyroid hormone level down from 553 to 238 pg/mL...
December 2017: Pediatrics
https://www.readbyqxmd.com/read/29189186/furosemide-soluplus%C3%A2-solid-dispersion-development-and-characterization
#12
Rammani Patwa, R Praveen, Sandeep Kumar Singh, Priya Ranjan Prasad Verma
Recent patents reveal that Soluplus® has proved to be a promising excipient that modulates dissolution characteristics of many active pharmaceutical ingredients (WO 2016161995 A1, WO 2016169534 A1, WO 2016165676 A1). Current article investigate on stable solid solution of furosemide with Soluplus to enhance the dissolution properties of the drug. Drug:carrier ratios to prepare solid dispersion was selected based on the phase solubility study. Solid dispersions of furosemide with Soluplus® were prepared by solvent evaporation and fusion method...
November 29, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29189185/enhanced-both-in-vitro-and-in-vivo-kinetics-by-slns-induced-transdermal-system-of-furosemide-a-novel-approach
#13
Revathi Mannam, Indira Muzib Yallamalli
AIM AND BACKGROUND: Furosemide is a potent diuretic agent used to treat pulmonary arterial hypertension. Variable dosage regimen and poor pharmacokinetic parameters has led to the development of transdermal drug delivery system. A patent on suitability of multi-lamellar structures for excellent transdermal delivery (US 0367475A1) has encouraged us to formulate the solid lipid nanoparticles (SLNs) induced transdermal systems of furosemide to enhance the kinetic properties without incorporating any penetration enhancer and rate limiting polymers...
November 28, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29174754/a-randomized-controlled-trial-of-a-single-dose-furosemide-to-improve-respiratory-distress-in-moderate-to-severe-bronchiolitis
#14
Kristy Williamson, Gabriel Bredin, Jahn Avarello, Sandeep Gangadharan
BACKGROUND: Bronchiolitis is one of the most common disorders of the lower respiratory tract in infants. While historically diuretics have been used in severe bronchiolitis, no studies have looked directly at their early use in children in the emergency department. OBJECTIVE: The primary objective of this study was to determine whether a single early dose of a diuretic in infants with moderate to severe bronchiolitis would improve respiratory distress. Secondary objectives examined whether it reduced the use of noninvasive ventilation and hospital length of stay...
November 22, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29171372/-two-pulmonary-lesions-on-an-x-ray-of-the-chest
#15
L Draaijers, I H van Schelven, Y Hendrix
We present an X-ray of a 89-year-old man, showing two solitary pulmonary lesions. Although malignancy was suspected, these lesions appeared to be intrafissural pleural effusions, caused by congestive heart failure. One week after treatment with furosemide, the pulmonary lesions had disappeared completely.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29169901/-transfusion-practices-in-elderly-patients-a-descriptive-study-about-241%C3%A2-patients-at-the-university-hospital-of-brest
#16
C Le Niger, N Magne Tagne, A Gentric
Red blood cell transfusion is commonly required for elderly patients with little specific guidelines for this population. We wished to study the transfusion practices for patients aged≥75 years transfused with red blood cells in all units of our institution. The aim of this work is to describe this population of patients and to compare the transfusion practices to the HAS and ANSM guidelines published in 2014. METHODS: An observational study was performed including patients≥75 years, transfused with red blood cells between 27th January to 27th March 2014...
November 20, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29167446/hyperpolarized-1-13-c-acetate-renal-metabolic-clearance-rate-mapping
#17
Emmeli F R Mikkelsen, Christian Østergaard Mariager, Thomas Nørlinger, Haiyun Qi, Rolf F Schulte, Steen Jakobsen, Jørgen Frøkiær, Michael Pedersen, Hans Stødkilde-Jørgensen, Christoffer Laustsen
(11)C-acetate is a positron emission tomography (PET) tracer of oxidative metabolism, whereas hyperpolarized (13)C-acetate can be used in magnetic resonance imaging (MRI) for investigating specific metabolic processes. The aims of this study were to examine if the kinetic formalism of (11)C-acetate PET in the kidneys is comparable to that of (13)C-acetate MRI, and to compare the dynamic metabolic information of hyperpolarized (13)C-acetate MRI with that obtained with (11)C-acetate PET. Rats were examined with dynamic hyperpolarized (13)C-acetate MRI or (11)C-acetate PET before and after intravenous injection of furosemide, a loop diuretic known to alter both the hemodynamics and oxygen consumption in the kidney...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167185/hyperacute-leucopenia-associated-with-furosemide
#18
Ben-Jiang Ma
A 72-year-old man presented to the hospital with exacerbation of congestive heart failure. He was given furosemide 40 mg intravenously twice at 4 hours apart. At 4 hours after the second dose of furosemide, his white blood cells (WBC) dropped acutely from 9.8 to 2.4×10(9)/L (reference range 4.1 to 9.3×10(9)/L). With the discontinuation of furosemide, the WBC trended up to 7.1×10(9)/L about 13 hours after the second dose of intravenous furosemide and remained in normal range for the next 3 days. However, when the oral furosemide was started on hospital day 4, there was a mild drop in WBC count, which returned to and maintained at baseline since the next day...
November 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29165723/the-impact-of-hyperosmolarity-on-long-term-outcome-in-patients-presenting-with-severe-hyperglycemic-crisis-a-population-based-study
#19
Ivan Kruljac, Miroslav Ćaćić, Petra Ćaćić, Lora Stanka Kirigin Biloš, Davor Kust, Božidar Perić, Maja Filipović-Grčić, Gorana Mirošević, Vedran Ostojić, Mario Štefanović, Milan Vrkljan
Aims We compared characteristics of patients with hyperglycemic hyperosmolar state (HHS) and patients with severe hyperglycemia without the signs of hyperosmolarity and ketoacidosis; analyzed long-term all-cause mortality and potential prognostic factors. Methods The studied population included 261 749 adults. HHS was diagnosed in patients with plasma glucose >33.0 mmol/L, ketonuria <1+, and serum osmolarity >320 mmol/L. Patients with plasma glucose >33.0 mmol/L, ketonuria <1+ and serum osmolarity <320 mmol/L were considered as controls (nHHS)...
November 17, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29162614/discovery-and-validation-of-pyridoxic-acid-and-homovanillic-acid-as-novel-endogenous-plasma-biomarkers-of-organic-anion-transporter-oat-1-and-oat3-in-cynomolgus-monkeys
#20
Hong Shen, David M Nelson, Regina V Oliveira, Yueping Zhang, Colleen A Mcnaney, Xiaomei Gu, Weiqi Chen, Ching Su, Michael D Reily, Petia A Shipkova, Jinping Gan, Yurong Lai, Punit Marathe, W Griffith Humphreys
Perturbation of OAT1- and OAT3-mediated transport can alter the exposure, efficacy, and safety of drugs. Although these have been reports of the endogenous biomarkers for OAT1/3, none of these have all of the characteristics required for a clinical useful biomarker. Cynomolgus monkeys were treated with intravenous probenecid (PROB) at a dose of 40 mg/kg in this study. As expected, PROB increased the AUC of co-administered furosemide (FSM), a known substrate of OAT1 and OAT3, by 4.1-fold, consistent with the values reported in humans (3...
November 21, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
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