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https://www.readbyqxmd.com/read/29046296/geraniin-is-a-diuretic-by-inhibiting-the-na-k-2cl-cotransporter-nkcc2
#1
Erika Moreno, Juan A Gayosso, Jose Ramón Montejano, Georgina Almaguer, Norma Vázquez, Cristino Cruz, Adriana Mercado, Norma A Bobadilla, Gerardo Gamba, Alfredo Sierra, Victoria Ramírez
Geranium seemannii Peyr is a perennial plant endemic in central Mexico that has been widely used for its diuretic effect, but the responsible compound of this effect is unknown as well as the mechanism by which the diuretic effect is achieved. Geraniin is one of the compounds isolated from this kind of geranium. This study was designed to determinate whether geraniin possesses diuretic activity and to elucidate the mechanism of action. Geraniin was extracted and purified from Geranium seemannii Peyr. Male Wistar rats were divided into four groups: 1) Control, 2) 75 mg/kg of geraniin, 3) 20 mg/Kg of furosemide, and 4) 10 mg/Kg of hydrochlorothiazide...
October 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29043398/oral-paracetamol-for-patent-ductus-arteriosus-rescue-closure
#2
Pramod Pharande, Hadley Watson, Kenneth Tan, Arvind Sehgal
The objective of this study was to ascertain the efficacy of oral paracetamol in closing a symptomatic patent ductus arteriosus (PDA) when used as 'rescue' option. After obtaining ethics approval, a retrospective appraisal of the data from April 2014 to July 2015 was performed. Infants who were administered oral paracetamol either after unsuccessful therapy with ibuprofen or where it was considered contraindicated were included. A previously published echocardiographic scoring schema to stratify for ductal disease severity was used...
October 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29038673/thiazides-and-osteoporotic-spinal-fractures-a-suspected-linkage-investigated-by-means-of-a-two-center-case-control-study
#3
Renato De Vecchis, Carmelina Ariano, Giuseppina Di Biase, Michel Noutsias
BACKGROUND: An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study. However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs, as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29035197/drug-induced-kidney-injury-a-large-case-series-from-the-berlin-case-control-surveillance-study%C3%A2
#4
Antonios Douros, Elisabeth Bronder, Andreas Klimpel, Christiane Erley, Edeltraut Garbe, Reinhold Kreutz
OBJECTIVES: Drug-induced kidney injury (DIKI) may affect patients regardless of their baseline kidney function. Therefore, this study evaluated DIKI in patients with or without previous chronic kidney disease (CKD). MATERIALS AND METHODS: Potential DIKI cases were ascertained using the network of the Berlin Case-Control Surveillance Study in all 51 Berlin hospitals from April 2010 until December 2011. Via face-to-face interviews and medical chart reviews, information on all previous drug intake, comorbidities, and demographics was gathered...
October 16, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29034718/the-prognostic-value-of-the-furosemide-stress-test-in-predicting-delayed-graft-function-following-deceased-donor-kidney-transplantation
#5
Blaithin A McMahon, Jay L Koyner, Tessa Novick, Steve Menez, Robert A Moran, Bonnie E Lonze, Niraj Desai, Sami Alasfar, Marvin Borja, William T Merritt, Promise Ariyo, Lakhmir S Chawla, Edward Kraus
OBJECTIVES AND METHODS: The Furosemide Stress Test (FST) is a novel dynamic assessment of tubular function that has been shown in preliminary studies to predict patients who will progress to advanced stage acute kidney injury, including those who receive renal replacement therapy (RRT). The aim of this study is to investigate if the urinary response to a single intraoperative dose of intravenous furosemide predicts delayed graft function (DGF) in patients undergoing deceased donor kidney transplant...
October 16, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29031573/aerosol-furosemide-for-dyspnea-controlled-delivery-does-not-improve-effectiveness
#6
Capucine Morélot-Panzini, Carl R O'Donnell, Robert W Lansing, Richard M Schwartzstein, Robert B Banzett
Aerosolized furosemide has been shown to relieve dyspnea; nevertheless, all published studies have shown great variability in response. This dyspnea relief is thought to result from the stimulation of slowly adapting pulmonary stretch receptors simulating larger tidal volume. We hypothesized that better control over aerosol administration would produce more consistent dyspnea relief; we used a clinical ventilator to control inspiratory flow and tidal volume. Twelve healthy volunteers inhaled furosemide (40mg) or placebo in a double blind, randomized, crossover study...
October 11, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29030065/diuretics-versus-volume-expansion-in-acute-submassive-pulmonary-embolism
#7
Elie Dan Schouver, Olivier Chiche, Priscille Bouvier, Denis Doyen, Pierre Cerboni, Pamela Moceri, Emile Ferrari
BACKGROUND: The benefit of volume expansion (VE) in submassive pulmonary embolism (PE) with right ventricular (RV) dysfunction is unclear. AIM: To compare the effects of diuretic treatment versus VE in patients hospitalized for PE with RV dysfunction. METHODS: We prospectively included 46 consecutive patients with submassive PE treated on admission with a 40mg bolus of furosemide (D group, n=24) or 500mL of saline infusion (VE group, n=22)...
October 10, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29024163/ultrasonographic-measurement-of-caudal-vena-cava-to-aorta-ratios-for-determination-of-volume-depletion-in-normal-beagle-dogs
#8
Jungmin Kwak, Hakyoung Yoon, Jaehwan Kim, Minjoo Kim, Kidong Eom
A noninvasive method for quantifying hydration status would be helpful for clinical management and for research applications in dogs. This prospective, experimental, pilot study aimed to assess the feasibility of ultrasonographic measurement of the caudal vena cava to aorta ratio as a method for quantifying volume depletion in dogs. In 12 normal beagle dogs, furosemide was administered intravenously at a dose of 1 mg/kg, every 2 h, for 8 h, to induce consecutive volume depletion. Every 30 min after administration, ultrasonographic images of the caudal vena cava and aorta, and physical and biological parameters related to dehydration were acquired...
October 10, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29022503/the-renal-outer-medullary-potassium-channel-romk-an-intriguing-pharmacological-target-for-an-innovative-class-of-diuretic-drugs
#9
Vincenzo Calderone, Alma Martelli, Eugenia Piragine, Valentina Citi, Lara Testai, Maria Cristina Breschi
In the last four decades, the several classes of diuretics, currently available for clinical use, have been the first line option for the therapy of widespread cardiovascular and non-cardiovascular diseases. Diuretic drugs generally exhibit an overall favourable risk/benefit balance. However, they are not devoid of side effects. In particular, all the classes of diuretics cause alteration of potassium homeostasis. In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28994887/hepatic-hydrothorax-about-a-hospital-serie-of-63-cases
#10
Leila Mouelhi, Oussama Daboussi, Nadia Cheffi, Kaouther El Jery, Yosra Said, Sana Khedher, Mohamed Salem, Radhouane Dabbèche, Fatma Houissa, Taoufik Najjar
BACKGROUND: Hepatic hydrothorax is a less common complication of cirrhosis with an estimated prevalence of 10- 15%. In the vast majority of cases, ascites are also present but significant pleural effusion may develop in patients without ascites. Hepatic hydrothorax is associated with cirrhosis whatever its etiology. The prognosis of hepatic hydrothorax remains unclear and is closely related to available therapeutic options. The aim of our study is to determine the prevalence of hydrothorax in cirrhotic patients, detail its clinical and therapeutic characteristics, and study the evolutive profile of cirrhotic patients with hydrothorax by comparing it to those without hydrothorax...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28984014/increased-serum-c-reactive-protein-and-decreased-urinary-aquaporin-2-levels-are-predictive-of-the-efficacy-of-tolvaptan-in-patients-with-liver-cirrhosis
#11
Masato Nakai, Koji Ogawa, Rei Takeda, Masatsugu Ohara, Naoki Kawagishi, Takaaki Izumi, Machiko Umemura, Jun Ito, Takuya Sho, Goki Suda, Kenichi Morikawa, Naoya Sakamoto
AIM: Water retention, hepatic ascites, and peripheral edema are significant problems in patients with liver cirrhosis (LC). Although furosemide and spironolactone are commonly used as treatment, these are often insufficient to treat hyponatremia and renal insufficiency in patients with LC. Tolvaptan (TVP) could provide an effective treatment alternative. However, predictive factors of a therapeutic response to TVP are unclear. Our aim was to examine clinical predictors of the response to TVP in patients with LC and water retention...
October 6, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28981821/sodium-carbonate-is-saltier-than-sodium-chloride-to-sodium-depleted-rats
#12
Steven J St John, Anya M McBrayer, Erin E Krauskopf
In a series of behavioral experiments in the 1960s, G.R. Morrison identified several unique features of the taste of Na2CO3 to rats; namely, it is 1) considerably more intense than NaCl at isomolar concentrations, 2) avoided at 10 times lower concentrations than NaCl to thirsty rats, 3) preferred at 10 times lower concentrations than NaCl in sodium-depleted rats. He also demonstrated its qualitatively similarity to NaCl. In Experiment 1, we confirmed and extended many of Morrison's observations. Rats were injected with furosemide on 3 occasions to stimulate a sodium appetite...
October 1, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28980452/rationale-and-study-design-of-intravenous-loop-diuretic-administration-in-acute-heart-failure-diur-ahf
#13
Alberto Palazzuoli, Gaetano Ruocco, Giorgio Vescovo, Roberto Valle, Salvatore Di Somma, Ranuccio Nuti
AIMS: Although loop diuretics are the most commonly used drugs in acute heart failure (AHF) treatment, their short-term and long-term effects are relatively unknown. The significance of worsening renal function occurrence during intravenous treatment is not clear enough. This trial aims to clarify all these features and contemplate whether continuous infusion is better than an intermittent strategy in terms of decongestion efficacy, diuretic efficiency, renal function, and long-term prognosis...
October 4, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28975664/short-term-efficacy-and-safety-of-torasemide-and-furosemide-in-366-dogs-with-degenerative-mitral-valve-disease-the-test-study
#14
V Chetboul, J-L Pouchelon, J Menard, J Blanc, L Desquilbet, A Petit, S Rougier, L Lucats, F Woehrle
BACKGROUND: Furosemide is the only loop diuretic recommended by the ACVIM consensus guidelines for treatment of congestive heart failure (CHF) in dogs related to degenerative mitral valve disease (DMVD). Torasemide is another potent loop diuretic with a longer half-life and a higher bioavailability. OBJECTIVES: (1) To demonstrate that torasemide given once a day (q24h) is noninferior to furosemide given twice a day (q12h) for treating dogs with CHF; (2) and to compare the effect of the 2 drugs on the time to reach a composite cardiac endpoint "spontaneous cardiac death, euthanasia due to heart failure or CHF class worsening...
October 4, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28975092/self-limited-membranous-nephropathy-after-intravitreal-bevacizumab-therapy-for-age-related-macular-degeneration
#15
Gebran Khneizer, Ahmad Al-Taee, Bahar Bastani
BACKGROUND: Monoclonal antibodies targeting vascular endothelial growth factor (VEGF), such as bevacizumab, are administered intravitreally for the treatment of wet or exudative age-related macular degeneration (ARMD). Systemic use of bevacizumab has been linked to a wide range of renal adverse effects including proteinuria and hypertension. CASE PRESENTATION: We present the case of a 77-year-old Caucasian male with a past medical history of hypertension, vitamin D deficiency and paroxysmal atrial fibrillation who presented to primary care clinic with a 2-week history of bilateral lower extremity edema, 2 months after completing four monthly intravitreal injections of bevacizumab for ARMD...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28971992/diuretic-state-affects-ascending-thin-limb-tight-junctions
#16
Svenja Rebecca Sonntag, Annalisa Ziemens, Vera Christine Wulfmeyer, Susanne Milatz, Markus Bleich, Nina Himmerkus
The nephron segments in the inner medulla are part of the urine concentrating mechanism. Depending on the diuretic state they are facing a large range of extracellular osmolality. We investigated whether water homeostasis affects tubular transport and permeability properties in inner medullary descending thin limb (IMdTL) and ascending thin limb (IMaTL). Three experimental groups of rats under different diuretic states were investigated on metabolic cages: waterload, furosemide induced diuresis and control (antidiuresis)...
September 27, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28971753/loop-diuretic-down-titration-in-stable-chronic-heart-failure-is-often-achievable-especially-when-urinary-chloride-concentration-is-low
#17
Frederik H Verbrugge, Pieter Martens, Levinia Boonen, Petra Nijst, David Verhaert, Patrick Noyens, Philip De Vusser, Matthias Dupont, W H Wilson Tang, Wilfried Mullens
BACKGROUND: This study investigates spot urinary chloride concentration in euvolemic chronic heart failure (CHF) patients. METHODS: This prospective cohort study included 50 ambulatory CHF patients on maintenance loop diuretics without recent hospital admission, clinical signs of volume overload, or adjustment in neurohumoral blocker or diuretic therapy. Spot urinary samples were collected immediately after loop diuretic intake. Subsequently, loop diuretic dose was reduced with 50% or stopped if ≤40 mg furosemide equivalents...
October 3, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28967699/the-association-between-high-dose-loop-diuretic-use-at-discharge-and-cardiovascular-mortality-in-patients-with-heart-failure
#18
Toshitaka Okabe, Tadayuki Yakushiji, Takehiko Kido, Yuji Oyama, Wataru Igawa, Morio Ono, Seitaro Ebara, Kennosuke Yamashita, Myong Hwa Yamamoto, Shigeo Saito, Kisaki Amemiya, Naoei Isomura, Masahiko Ochiai
AIMS: Few studies have reported the impact of high-dose loop diuretics at discharge on prognosis in Japanese patients with heart failure (HF). Our purpose was to assess the relationship between the dose of loop diuretics at discharge and cardiovascular mortality in patients with HF. METHODS AND RESULTS: We enrolled decompensated HF patients who were admitted to our hospital between March 2010 and March 2015, and compared HF patients who received high-dose loop diuretics at discharge (HD group) with low-dose loop diuretics at discharge (LD group) with regard to risk of cardiovascular mortality, and all-cause mortality...
October 2, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28965280/acetazolamide-as-add-on-diuretic-therapy-in-exacerbations-of-chronic-heart-failure-a-pilot-study
#19
Tomasz Imiela, Andrzej Budaj
BACKGROUND: Congestion is the main cause of morbidity in patients with heart failure. Treatment of fluid overload is often challenging in everyday clinical practice. OBJECTIVE: The aim of this study was to determine the diuretic effect of acetazolamide in patients with exacerbations of chronic heart failure, in addition to their stable diuretic therapy. METHODS: This was a single-center, unblinded study. Patients hospitalized with chronic heart failure exacerbations, with left ventricular ejection fraction (EF) < 50% and signs of volume overload, with a stable dose of diuretics anticipated by the attending physician over the next 4 days, were considered eligible for the study...
September 30, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28963734/effectiveness-of-furosemide-in-attenuating-exercise-induced-pulmonary-haemorrhage-in-horses-when-administered-at-4-and-24-hours-prior-to-high-speed-training
#20
H K Knych, W D Wilson, A Vale, P H Kass, R M Arthur, J H Jones
BACKGROUND: Due to the high prevalence of EIPH in racehorses and its potential impact on the horse's health, furosemide administration is permitted up to 4-h prior to post time in most North American racing jurisdictions. Anecdotal reports suggest that administration of furosemide 24-h prior to strenuous exercise may be equally effective in decreasing the severity of EIPH. OBJECTIVES: (1) compare the efficacy of furosemide in reducing the presence and severity of EIPH when administered 4 or 24-h prior to strenuous exercise (2) characterise electrolyte and blood parameters following administration of furosemide at 4- and 24-h prior to exercise...
September 30, 2017: Equine Veterinary Journal
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