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https://www.readbyqxmd.com/read/29140943/antibodies-toward-vedolizumab-appear-from-the-first-infusion-onward-and-disappear-over-time
#1
Sumin Bian, Erwin Dreesen, Ho Tsun Tang, Griet Compernolle, Miet Peeters, Gert Van Assche, Marc Ferrante, Séverine Vermeire, Ann Gils
BACKGROUND: Vedolizumab (VDZ) has been approved for the treatment of patients with moderate-to-severe Crohn's disease and ulcerative colitis. The GEMINI trials reported a low prevalence of anti-VDZ antibodies (AVA). However, the AVA assays used in GEMINI were drug sensitive, resulting in a possible underestimation of the rate of AVA formation. This study aimed to monitor immunogenicity of VDZ in a real-life cohort using a drug-resistant AVA assay. METHODS: Using a combination of VDZ/AVA complex precipitation and acid dissociation, a drug-resistant assay for AVA detection in the presence of high VDZ concentrations has been developed and analytically validated...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29129898/aggregation-behavior-of-disulfide-linked-gemini-surfactants-compared-to-that-of-double-tailed-surfactants
#2
Yukina Takano, Tsuyoshi Asakawa, Mayumi Inai, Akio Ohta, Hitoshi Asakawa
Disulfide linked gemini surfactant having a long spacer chain, [C10H21N(CH3)2(CH2)11SS(CH2)11N (CH3)2C10H21]2Br (2C1011SS), was prepared by the hydrolysis and oxidation process of thioester group for [C10H21N(CH3)2(CH2)11SCOCH3]Br. The critical vesicle concentrations of double tailed surfactants such as dialkyldimethylammonium bromide were observed by the conductivity and light scattering methods. The disulfide bonds of gemini surfactant, [C12H25N(CH3)2CH2CH2SSCH2CH2N(CH3)2C12H25]2Br (2C12SS), were rapidly cleaved by the addition of water-soluble dithiothreitol...
November 13, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29128838/transfection-of-plasmid-dna-by-nanocarriers-containing-a-gemini-cationic-lipid-with-an-aromatic-spacer-or-its-monomeric-counterpart
#3
María Martínez-Negro, Ana L Barrán-Berdón, Clara Aicart-Ramos, María L Moyá, Conchita Tros de Ilarduya, Emilio Aicart, Elena Junquera
This study performed a biophysical characterization (electrochemistry, structure and morphology) and assessment of the biological activity and cell biocompatibility of GCL/DOPE-pDNA lipoplexes comprised of plasmid DNA and a mixed lipid formed by a DOPE zwitterionic lipid and a gemini cationic lipid N-N'-(1,3-phenylene bis (methylene)) bis (N,N-dimethyl-N-(1-dodecyl) ammonium dibromide (12PH12) containing an aromatic spacer or its monomeric counterpart surfactant, N-benzyl-N,N-dimethyl-N-(1-dodecyl) ammonium bromide (12PH)...
November 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29112925/effective-dispersion-of-multi-walled-carbon-nanotubes-in-aqueous-solution-using-an-ionic-gemini-dispersant
#4
Jiangtao Hou, Wenbo Du, Fanjing Meng, Chenchen Zhao, Xian Du
A promising ionic-gemini molecule, 4, 4'-di (n-tetradecyl) diphenylmethane disulfate salt (DSDM), is reported for effective dispersion of multi-walled carbon nanotubes (MWCNTs) in aqueous medium in the present investigation. The dispersibility and stability of the DSDM-modified MWCNTs were characterized by UV-vis spectrophotometer, Raman spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy and zeta potential measurements. The hydrophobic interaction between alky chains and carbon nanotubes as well as the π-π-stacking interaction between benzene rings and carboatomic rings in MWCNTs enables a successful modification of DSDM onto the MWCNT surface...
October 31, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29095616/the-driving-force-for-the-association-of-gemini-surfactants
#5
Kyeong-Jun Jeong, Arun Yethiraj
The self-assembly of surfactants into lyotropic liquid crystalline phases is interesting from a fundamental and practical perspective. The propensity for self-assembly is particularly interesting in Gemini surfactants which have a very low critical micelle concentration. In this work we study the effect of head-group identity on the driving force for the self-assembly of Gemini surfactants, using computer simulations of the potential of mean force (PMF). We find that surfactants with sulfonate head-groups have a greater tendency to assemble than those with carboxylate head-groups...
November 2, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29081667/cost-effectiveness-of-vedolizumab-compared-with-conventional-therapy-for-ulcerative-colitis-patients-in-the-uk
#6
Michele R Wilson, Ismail Azzabi Zouraq, Helene Chevrou-Severac, Ross Selby, Matthew C Kerrigan
OBJECTIVE: To examine the clinical and economic impact of vedolizumab compared with conventional therapy in the treatment of moderately-to-severely active ulcerative colitis (UC) in the UK based on results of the GEMINI I trial. METHODS: A decision-analytic model in Microsoft Excel was used to compare vedolizumab with conventional therapy (aminosalicylates, corticosteroids, immunomodulators) for the treatment of patients with UC in the UK. We considered the following three populations: the overall intent-to-treat population from the GEMINI I trial, patients naïve to anti-TNF therapy, and those who had failed anti-TNF-therapy...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29080566/removal-efficiency-of-different-gemini-surfactants-and-related-modified-clay-to-chattonella-marina
#7
Wen-Wen Wang, Xin-Ya Yan, Yun-Hui Li, De-Ren Yu, Hong-Ye Li, Wei-Dong Yang, Jie-Sheng Liu
  To obtain new modified clays with excellent algae removal efficiency, three gemini surfactants including ethylene bis (dodecyl dimethyl ammonium chloride), ethylene bis (octadecyl dimethyl ammonium chloride) and ethylene bis (dodecyl dimethyl ammonium bromide) (EDAB), and a poly quaternary ammonium salt, poly dimethyl diallyl ammonium chloride, were screened with Chattonella marina. The four chemicals all exhibited high removal efficiencies against C. marina, with EDAB achieving the highest. A series of organ-clays with different ratios of EDAB were prepared, and the associated removal efficiencies were evaluated...
November 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/29072118/multiple-spectroscopic-studies-of-the-interaction-between-a-quaternary-ammonium-based-cationic-gemini-surfactant-as-a-carrier-and-human-erythropoietin
#8
Masoud Bagherpour Zarchi, Adeleh Divsalar, Kataneh Abrari, Arezou Rezaei
Erythropoietin (EPO) is a hematopoietic growth factor. This substance, as a strong cell protector, can increase cell maintenance during different damages of central nervous system. Since the brain-blood barrier prevents the entrance of large proteins similar to EPO into the brain, its systemic delivery gets limited. The aim of this study was to find an alternative approach for EPO delivery into the brain to skip the blood-brain barrier prevention. So, a new quaternary ammonium-based cationic Gemini surfactant has been used to study the interaction of the cationic Gemini surfactant (as a carrier) with EPO using various spectroscopic techniques of (fluorescence and circular dichroism (CD)) and thermal denaturation...
October 26, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29067793/nanostructured-gemini-based-supramolecular-solvent-coupled-with-ultrasound-assisted-back-extraction-as-a-preconcentration-step-before-gc-ms
#9
Neda Feizi, Yadollah Yamini, Morteza Moradi, Qamar Salamat
Liquid-phase microextraction based on gemini-based supramolecular solvent was successfully applied as a preconcentration step before gas chromatography with mass spectrometry. To eliminate the interferences of gemini surfactant, the analytes were back-extracted into an immiscible organic solvent in the presence of ultrasonic sound waves. Three phthalate esters (di-n-butyl-, butylbenzyl-, bis(2-ethylhexyl)-, and di-n-octyl phthalatic esters) were used as target analytes. The effective parameters on extraction efficiency of the target analytes (i...
October 25, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29067393/ph-responsive-self-assembly-of-cationic-surfactants-with-a-star-shaped-tetra-carboxylate-acid-and-the-solubilization-of-hydrophobic-drugs
#10
Ruilian Qi, Zhang Liu, Chengcheng Zhou, Yuchun Han, Yilin Wang
This work involved the construction of pH-responsive self-assembly systems from a pH-sensitive four-arm carboxylate acid (4EOCOOH) and either the cationic single chain surfactant dodecyl trimethyl ammonium bromide (DTAB) or the cationic gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (12-6-12). It was found that the constructed oligomeric-like structures from the mixtures of 4EOCOOH with DTAB or 12-6-12 greatly enhance the aggregation ability of the mixtures, thus improving the pH-responsivity...
October 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/29065563/silver-nanoparticles-stabilised-by-cationic-gemini-surfactants-with-variable-spacer-length
#11
Martin Pisárčik, Josef Jampílek, Miloš Lukáč, Renáta Horáková, Ferdinand Devínsky, Marián Bukovský, Michal Kalina, Jakub Tkacz, Tomáš Opravil
The present study is focused on the synthesis and investigation of the physicochemical and biological properties of silver nanoparticles stabilized with a series of cationic gemini surfactants having a polymethylene spacer of variable length. UV-VIS spectroscopy, dynamic light scattering, scanning electron microscopy and zeta potential measurements were applied to provide physicochemical characterization of the silver nanoparticles. The mean size values of the nanoparticles were found to be in the 50 to 115 nm range...
October 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29064700/critical-role-of-the-spacer-length-of-gemini-surfactants-on-the-formation-of-ionic-liquid-crystals-and-thermotropic-behavior
#12
Ricardo M F Fernandes, Yujie Wang, Pedro B Tavares, Sandra C C Nunes, Alberto A C C Pais, Eduardo F Marques
Numerous reports have shown that the self-assembling properties of 12-s-12 bis(quaternary ammonium) gemini surfactants in aqueous solution are significantly influenced by s, the number of methylene groups in the covalent spacer. However, the role played by s on the phase behavior of the single compounds has not been investigated in a similarly systematic way. Here, we report on the thermotropic phase behavior of the anhydrous compounds with s = 2-6, 8, 10, and 12, resorting to differential scanning calorimetry (DSC), polarized light microscopy (PLM), and X-ray diffraction (XRD)...
November 9, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29048491/simultaneous-quantification-of-eight-marker-compounds-in-yongdamsagan-tang-using-a-high-performance-liquid-chromatography-equipped-with-photodiode-array-detector
#13
Chang-Seob Seo, Hyeun-Kyoo Shin
Yongdamsagan-tang (YDSGT) has been used clinically for the treatment of acute- and chronic-urethritis, cystitis, orchitis and hypertension in Korea. In this study, a powerful method based on high-performance liquid chromatography (HPLC) with photodiode array (PDA) detection was established and validated for the quantitative analysis of eight components: chlorogenic acid, gentiopicroside, liquiritin apioside, liquiritin, nodakenin, baicalin, wogonoside and glycyrrhizin in YDSGT extract. The compounds were separated with a Gemini C18 analytical column (column temperature: 40°C; mobile phase: 0...
October 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29048262/genetic-and-environmental-influences-on-developmental-milestones-and-movement-results-from-the-gemini-cohort-study
#14
Lee Smith, Cornelia H M van Jaarsveld, Clare H Llewellyn, Alison Fildes, Guillermo Felipe López Sánchez, Jane Wardle, Abigail Fisher
PURPOSE: Variability in the timing of infant developmental milestones is poorly understood. We used a twin analysis to estimate genetic and environmental influences on motor development and activity levels in infancy. METHOD: Data were from the Gemini Study, a twin birth cohort of 2,402 families with twins born in the United Kingdom in 2007. Parents reported motor activity level for each of the twins at age 3 months using the Revised Infant Behavior Rating Scale and reported the ages at which they first sat unsupported, crawled, and walked unaided...
October 19, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/29032048/cytokine-profile-changes-in-gingival-crevicular-fluid-after-placement-different-brackets-types
#15
Ana Zilda Nazar Bergamo, Paulo Nelson-Filho, Cássio do Nascimento, Renato Corrêa Viana Casarin, Márcio Zaffalon Casati, Marcela Cristina Damião Andrucioli, Érika Calvano Kuchler, Daniele Lucca Longo, Léa Assed Bezerra da Silva, Mírian Aiko Nakane Matsumoto
OBJECTIVE: The aim of this study was to examine the relationship between bracket design and ratio of five proinflammatory cytokine, in gingival crevicular fluid (GCF), and bacterial adhesion without tooth movement influence. DESIGN: The sample was comprised of 20 participants, aged 11 to 15 years old (mean age: 13.3 years±1.03). A conventional Gemini™ metallic bracket and two self-ligating brackets, In-Ovation(®)R and SmartClip™, were bonded to the maxillary incisors and canines...
September 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29028356/aggregation-of-a-cationic-gemini-surfactant-with-a-chelating-molecule-and-effects-from-calcium-ions
#16
Weiwei Zhao, Kai Song, Yao Chen, Hua Wang, Zhang Liu, Qiang Shi, Jianbin Huang, Yilin Wang
The aggregation behavior of cationic ammonium gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (12-6-12) with chelating molecule ethylenediaminetetraacetic acid (EDTA) and the effects of calcium bromide (CaBr2) on the structure and morphology of the aggregates in the mixture have been investigated by surface tension, isothermal titration microcalorimetry, electrical conductivity, ζ potential, dynamic light scattering, cryogenic transmission electron microscopy, freeze-fracture transmission electron microscopy, and (1)H NMR techniques...
October 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28985284/determination-of-five-aminoalcohol-diterpenoid-alkaloids-in-the-lateral-root-of-aconitum-carmichaeli-by-hplc-elsd-with-spe
#17
Dan Huang, Xinqing Zhao, Xiuxiu Liu, Ruobing Chao
A convenient and accurate high-performance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD) method using solid phase extraction (SPE) was established for quantification of five aminoalcohol-diterpenoid alkaloids (ADAs), including mesaconine, aconine, hypaconine, fuziline and neoline, in the lateral roots of Aconitum carmichaeli (Fuzi) for the first time. The Fuzi extractive was purified using strong cation-exchange SPE. The chromatographic separation was performed on a Gemini C18 column (150 × 4...
July 14, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28953259/time-dependent-antimicrobial-activity-of-filtering-nonwovens-with-gemini-surfactant-based-biocides
#18
Katarzyna Majchrzycka, Małgorzata Okrasa, Justyna Szulc, Bogumił Brycki, Beata Gutarowska
Previous studies on nonwovens used for respiratory protective devices (RPDs) were related to equipment intended for short-term use. There is only limited research on the development of biocidal nonwoven fabrics for reusable RPDs that could be used safely in an industrial work environment where there is a risk of microbial growth. Moreover, a new group of biocides with high antimicrobial activity-gemini surfactants, has never been explored for textile's application in previous studies. The aim of this study was to develop high-efficiency melt-blown nonwovens containing gemini surfactants with time-dependent biocidal activity, and to validate their antimicrobial properties under conditions simulating their use at a plant biomass-processing unit...
September 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28947724/-after-the-gemini-acs-1-trial
#19
Mehmet Birhan Yılmaz
The GEMINI-ACS-1 trial has recently been published. It was designed to test whether low dose rivaroxaban as an antithrombotic agent is as safe as aspirin in patients with acute coronary syndromes (ACS). The trial is important to set light to future of ACS management.
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28929563/morphology-dependent-cell-imaging-by-using-a-self-assembled-diacetylene-peptide-amphiphile
#20
Hao Jiang, Xiao-Yu Hu, Stefanie Schlesiger, Mao Li, Eilo Zellermann, Shirley K Knauer, Carsten Schmuck
Herein, a novel cationic peptide gemini amphiphile containing diacetylene motifs (DA2 P) is presented, which self-assembles into novel tadpole- and bola-shaped nanostructures at low concentrations and nanofibers at higher concentrations. Interestingly, the DA2 P assemblies can be polymerized into a fluorescent red phase but only during incubation with HeLa cells, most likely owing to the reorganization of the diacetylene chains of DA2 P upon interaction with the cell membrane. The red-fluorescent polymerized DA2 P assemblies can serve as a novel cell imaging probe...
September 20, 2017: Angewandte Chemie
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