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Naing Lin Shan, Joseph Wahler, Hong Jin Lee, Min Ji Bak, Soumyasri Das Gupta, Hubert Maehr, Nanjoo Suh
Triple-negative breast cancer is one of the least responsive breast cancer subtypes to available targeted therapies due to the absence of hormonal receptors, aggressive phenotypes, and the high rate of relapse. Early breast cancer prevention may therefore play an important role in delaying the progression of triple-negative breast cancer. Cancer stem cells are a subset of cancer cells that are thought to be responsible for tumor progression, treatment resistance, and metastasis. We have previously shown that vitamin D compounds, including a Gemini vitamin D analog BXL0124, suppress progression of ductal carcinoma in situ in vivo and inhibit cancer stem-like cells in MCF10DCIS mammosphere cultures...
December 3, 2016: Journal of Steroid Biochemistry and Molecular Biology
Terrie Livingston, Monica Fay, Ravi Iyer, Wendy Wells, Michael W Pill
BACKGROUND: Multiple sclerosis (MS) is a chronic and debilitating disease of the central nervous system that affects more than 570,000 persons in the United States and 2.3 million worldwide. Since most individuals experience initial symptoms between the ages of 20 and 40 years, MS can have a significant effect on health care consumption, quality of life, productivity, and employment over the long-term disease course. Opportunities exist to better understand how benefit design and other nonclinical factors can affect health care delivery and associated costs...
December 2016: Journal of Managed Care & Specialty Pharmacy
A Mohammed Siddiq, Thanusu Parandhaman, A Farzana Begam, Sujoy K Das, Md Sayem Alam
In this report, we describe the effect of Gemini surfactants1, 6-Bis (N, N-hexadecyldimethylammonium) adipate (16-6-16) on synthesis, stability and antibacterial activity of silver nanoparticles (AgNPs). The stabilizing effect of Gemini surfactant and aggregation behavior of AgNPs was evaluated by plasmonic property and morphology of the AgNPs were characterized by UV-vis spectroscopy, Dynamic Light Scattering (DLS), X-ray diffraction (XRD), High resolution transmission electron microscopy (HRTEM) and Energy dispersive X-ray analysis (EDX) techniques...
December 2016: Enzyme and Microbial Technology
August Kuwawenaruwa, Gemini Mtei, Jitihada Baraka, Kassimu Tani
BACKGROUND: Inequity in access and use of child and maternal health services is impeding progress towards reduction of maternal mortality in low-income countries. To address low usage of maternal and newborn health care services as well as financial protection of families, some countries have adopted demand-side financing. In 2010, Tanzania introduced free health insurance cards to pregnant women and their families to influence access, use, and provision of health services. However, little is known about whether the use of the maternal and child health cards improved equity in access and use of maternal and child health care services...
November 18, 2016: Journal of Health, Population, and Nutrition
B G Feagan, H Patel, J-F Colombel, D T Rubin, A James, R Mody, K Lasch
BACKGROUND: Health-related quality of life (HRQL) is often diminished in patients with ulcerative colitis. AIM: To evaluate the effects of vedolizumab on HRQL in patients with ulcerative colitis. METHODS: Using maintenance phase data from the GEMINI 1 study, an analysis of covariance model was used to calculate mean differences between the vedolizumab and placebo groups in changes from baseline to week 52 for 3 HRQL instruments: The Inflammatory Bowel Disease Questionnaire (IBDQ), 36-Item Short Form Health Survey (SF-36), and EQ-5D...
November 17, 2016: Alimentary Pharmacology & Therapeutics
Yan Jin, Jing Zhao, Kyung Min Jeong, Da Eun Yoo, Se Young Han, Su-Young Choi, Dong-Hyeon Ko, Hyun-Ji Kim, Na-Hye Sung, Jeongmi Lee
A reliable analytical method based on high-performance liquid chromatography-ultraviolet detection was established for the determination of oleanonic acid (OA) content in Chios gum mastic (CGM). A simple method involving methanol extraction of CGM powder followed by basification and ether extraction was developed to isolate the triterpenic fraction including OA. The triterpenic fraction was chromatographed on a Phenomenex Gemini C18 column (150 × 4.6 mm, 5 µm) under a simple gradient elution of a mobile phase containing acetonitrile and water at a flow rate of 1...
November 17, 2016: Archives of Pharmacal Research
Hongsheng Lu, Cunchuan Zheng, Miao Xue, Zhiyu Huang
A zwitterionic gemini surfactant, called 2,2'-(1,4-phenylenebis(oxy))bis(N,N-dimethyl)-N-carboxyethyl-N-(alkylamide propyl) ammonium chloride (C14-B-C14), was synthesized successfully. The surfactant molecule exhibits various states at different pH values due to the two pH-sensitive carboxylate groups in the molecule. The surface activity and aggregate behaviors of C14-B-C14 in the aqueous solution were investigated under different pH conditions. The surface activities of the surfactant decrease with the increase in pH due to higher hydrophilic properties under basic conditions...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
Carlo Boselli, Roberto Cirocchi, Alessandro Gemini, Francesco Barberini, Veronica Grassi, Stefano Avenia, Andrea Polistena, Alessandro Sanguinetti, Daniele Pironi, Alberto Santoro, Renata Tabola, Nicola Avenia
INTRODUCTION: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms (85%) of the gastrointestinal (GI) tract; duodenal GISTs constitute 3-5% of all GISTs and represent 10-30% of all malignant tumours of the duodenum. Rarely, patients present severe bowel obstruction, perforation or severe bleeding. The radical resection with complete removal of the tumour remains the main therapeutic approach. We performed a local resection in patients with suspected GIST admitted for emergency treatment for GI bleeding...
November 14, 2016: Aging Clinical and Experimental Research
Carlo Boselli, Roberto Cirocchi, Alessandro Gemini, Veronica Grassi, Stefano Avenia, Andrea Polistena, Alessandro Sanguinetti, Maria Federica Burattini, Daniele Pironi, Alberto Santoro, Renata Tabola, Nicola Avenia
INTRODUCTION: Colon cancer therapy is primarily surgical. Advanced age does not represent a contraindication to surgery. We analyse the results of surgery in ultra 75 patients undergoing surgery for colorectal cancer by examining the correlation between the comorbidity and any post-operative complications. MATERIALS AND METHODS: We surgically treated 66 patients for colorectal cancer, aged over 75. The examined subjects were compromised for various reasons. We have evaluated the different influences of risk factors in elective and urgency operation...
November 11, 2016: Aging Clinical and Experimental Research
Jonathan G Martin, Scott T Hollenbeck, Gemini Janas, Ryan A Makar, Waleska M Pabon-Ramos, Paul V Suhocki, Michael J Miller, David R Sopko, Tony P Smith, Charles Y Kim
PURPOSE: To compare early outcomes of skin closure with octyl cyanoacrylate skin adhesive versus subcuticular suture closure. MATERIALS AND METHODS: Over a 7-month period, 109 subjects (28 men and 81 women; mean age, 58.6 y) scheduled to undergo single-lumen implantable venous port insertion for chemotherapy were randomly assigned to skin closure with either octyl cyanoacrylate skin adhesive or absorbable subcuticular suture after suturing the deep dermal layer...
November 8, 2016: Journal of Vascular and Interventional Radiology: JVIR
Carlo Boselli, Alessandro Gemini, Roberto Cirocchi, Veronica Grassi, Stefano Avenia, Andrea Polistena, Alessandro Sanguinetti, Daniele Pironi, Alberto Santoro, Renata Tabola, Maria Federica Burattini, Nicola Avenia
BACKGROUND: Diverticular disease of the colon also affects older people. Generally, older patients with diverticulitis may be regarded as too risky to undergo surgery. This retroprospective multicentric observational study aims to assess the safety and benefits of laparoscopic peritoneal lavage (LPL) in elderly patients with perforated sigmoid diverticulitis. PATIENTS AND METHOD: We hospitalized in urgency 100 patients, aged over 75, for sigmoid diverticulitis. Sixty-nine patients were treated with conservative medical therapy, while 31 were treated surgically, in which the surgery was performed in urgency in 18 cases, while in election in 13 cases...
November 9, 2016: Aging Clinical and Experimental Research
Renata Tabola, George Mantese, Roberto Cirocchi, Alessandro Gemini, Veronica Grassi, Carlo Boselli, Stefano Avenia, Alessandro Sanguinetti, Nicola Avenia, Maciej Sroczynski, Jaroslaw Wierzbicki
INTRODUCTION: Even with the advances in surgical technique and perioperative care, morbidity and mortality after colorectal cancer surgery remain considerable, and patients (pt) who present as an emergency have an even higher mortality and morbidity rate. METHODS: A total of 35 pt with caecum or ascending colon cancer between January 2007 and June 2015, three departments in Italy and in Poland, were included in the study. The intention of surgery in all cases was curative resection with ileo-colic anastomosis...
November 9, 2016: Aging Clinical and Experimental Research
Ingrid Arijs, Gert De Hertogh, Bart Lemmens, Leentje Van Lommel, Magali de Bruyn, Wiebe Vanhove, Isabelle Cleynen, Kathleen Machiels, Marc Ferrante, Frans Schuit, Gert Van Assche, Paul Rutgeerts, Severine Vermeire
OBJECTIVE: Lymphocyte recruitment to the inflamed gut is increased in UC. Inhibition of this cell trafficking by vedolizumab (VDZ) was successful in inducing and maintaining remission and in induction of endoscopic mucosal healing. There are no data on histological healing with VDZ. We studied histological changes following VDZ therapy and compared gene expression in patients with UC before and after therapy. DESIGN: Forty-one patients with UC from GEMINI I and LTS were studied before and at three time points (weeks 6/12/52) following VDZ therapy...
October 7, 2016: Gut
Tongtong Tian, Qiongzheng Hu, Yi Wang, Yanan Gao, Li Yu
A series of imidazolium-based surface active ionic liquids (IM-SAILs), viz. single-chained IM-SAILs, 1-alkyl-3-methylimidazolium bromide ([Cnmim]Br, n=12, 14, 16), 1-dodecyl-3-methylimidazolium salicylate ([C12mim]Sal), 1-dodecyl-3-methylimidazolium 3-hydroxy-2-naphthoate ([C12mim]HNC), 1-dodecyl-3-methylimidazolium cinnamate ([C12mim]CA), 1-dodecyl-3-methylimidazolium para-hydroxy-cinnamate ([C12mim]PCA); gemini IM-SAIL, 1,2-bis(3-dodecylimidazolium-1-yl) ethane bromide ([C12-2-C12im]Br2), along with three short-chained ionic liquids (ILs), ethylammonium nitrate (EAN), propylammonium nitrate (PAN) and butylammonium nitrate (BAN), were synthesized and applied to nematic liquid crystal (LC)-fluid interfaces...
October 26, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Emilia Fisicaro, Carlotta Compari, Franco Bacciottini, Laura Contardi, Erika Pongiluppi, Nadia Barbero, Guido Viscardi, Pierluigi Quagliotto, Gaetano Donofrio, Marie Pierre Krafft
Biological and thermodynamic properties of a new homologous series of highly fluorinated bispyridinium cationic gemini surfactants, differing in the length of the spacer bridging the pyridinium polar heads in 1,1' position, are reported for the first time. Interestingly, gene delivery ability is closely associated with the spacer length due to a structural change of the molecule in solution. This conformation change is allowed when the spacer reaches the right length, and it is suggested by the trends of the apparent and partial molar enthalpies vs molality...
October 15, 2016: Journal of Colloid and Interface Science
Sitah F Alanazi, Khalid S Alzimami, Magdy M Ghannam, Ibrahim J Aljammaz, Faisal Alrumayan, Salem A Sassi
PURPOSE: Interest in PET imaging using zirconium-89 (Zr) (t1/2=78.41 h)-labeled tracers for the tracking and quantification of monoclonal antibodies (mAbs) is growing, mainly because of its well-matched physical half-life with the biological half-life of intact mAbs. This study aims to evaluate the imaging characteristics of Zr-PET in comparison with those obtained using fluorine-18 fluorodeoxyglucose (F-FDG) PET (gold standard tracer in PET imaging) using a Time-Of-Flight (TOF) PET/computed tomography (CT) scanner...
October 4, 2016: Nuclear Medicine Communications
Andrea D Smith, Moritz Herle, Alison Fildes, Lucy Cooke, Silje Steinsbekk, Clare H Llewellyn
BACKGROUND: 'Food fussiness' (FF) is the tendency to be highly selective about which foods one is willing to eat, and emerges in early childhood; 'food neophobia' (FN) is a closely related characteristic but specifically refers to rejection of unfamiliar food. These behaviors are associated, but the extent to which their etiological architecture overlaps is unknown. The objective of this study was to quantify the relative contribution of genetic and environmental influences to variation in FF and FN in early childhood; and to establish the extent to which they share common genetic and environmental influences...
October 14, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Lijuan Shi, Panpan Sun, Liqiang Zheng
Gemini supra-amphiphiles with different spacer lengths, [M-n-M](2+)@2[DBS](-) (n = 2, 6, 10), were easily constructed. The conformational flexibility and hydrophobicity of the spacer group can be effectively tailored through regulating the spacer length, leading to the fine control of the topologies and subsequent hierarchical self-assemblies of [M-n-M](2+)@2[DBS](-). Vesicles are primarily fabricated by [M-n-M](2+)@2[DBS](-), and then successively fused into vesicle clusters, nanotubes, and planar bilayers, whose bilayer curvatures are gradually decreased, with increasing spacer length...
October 7, 2016: Soft Matter
Takuro Matsumoto, Ayaka Ono, Takahiro Ichikawa, Takashi Kato, Hiroyuki Ohno
Gemini amphiphilic zwitterions exhibit thermotropic bicontinuous cubic liquid-crystalline phases having a 3D continuous ionic domain. Incorporation of an acid into the materials led to the creation of novel electrolytes transporting protons efficiently through the 3D continuous domain.
October 6, 2016: Chemical Communications: Chem Comm
Tahereh Fereidooni Moghadam, Saeid Azizian, Shawn Wettig
In this paper the interfacial behavior of aqueous solutions of cationic gemini surfactants of the, N,N'-bis(dimethylalkyl)-α,ω-alkanediammoniumdibromide type (known as the 12-s-12 series), in the absence and presence of ZnO nanoparticles was studied. Equilibrium and dynamic interfacial tension between n-decane and aqueous surfactant solutions were investigated. It was concluded that the synergistic effect between surfactants and nanoparticles increases the surfactant efficiency with respect to reducing the interfacial tension...
September 28, 2016: Journal of Colloid and Interface Science
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