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Chuanhong Han, Yan Guo, Xiaoxiao Chen, Meihuan Yao, Yingtian Zhang, Qirui Zhang, Xilian Wei
The phase behaviour of a ternary system composed of cationic gemini surfactant 2-hydroxypropyl-1,3-bis(myristyldimethylammonium chloride) (14-3(OH)-14(2Cl)), nonionic surfactant polyoxyethylene laurel ether (C12H25(OCH2CH2)10OH, Brij-30) and H2O was studied and its phase diagram was determined. In several different phase regions identified in the phase diagram, the viscoelastic worm-like micellar solution region was investigated. The focus of the investigation was the increase in the viscosity of the micellar solution with the temperature and the Brij-30 content, as suggested by a partial region of the triangular phase diagram...
January 18, 2017: Soft Matter
Il-Dong Song, Je-Seop Kang, Hyun-Jin Kim, Se-Mi Kim, Dong-Xu Zhao, Shin-Hee Kim, Min-Young Chun, Kyuhyun Lee
We developed a simple and validated liquid chromatography tandem mass spectrometry(LC-MS/MS) for quantification of etodolac using pioglitazone as an internal standard (IS) to assess pharmacokinetics and to appraise bioequivalence of two formulations of etodolac (reference and tested) in 27 healthy Korean subjects. Isocratic mobile phase consisted of 10 mM ammonium formate and acetonitrile were used to separate the analytes on a Gemini C18 column. Also, analytes were analyzed by MS/MS in multiple reaction monitoring (MRM) mode using the transitions of (M+H)+ ions, m/z 288...
16, 2017: Drug Metabolism Letters
Sara Falsini, Emanuela Di Cola, Martin In, Maria Giordani, Stefano Borocci, Sandra Ristori
Gene therapy is based on nucleic acid delivery to pathogenic cells in order to modulate their gene expression. The most used non viral vectors are lipid-based nanoaggregates, which are safer than viral carriers and have been shown to assemble easily with both DNA and RNA. However, the transfection efficiency of non viral carriers still needs to be improved before intensive practise in clinical trials can be implemented. For this purpose, the in depth characterization of the complexes formed by nucleic acids and their transporters is of great relevance...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
Vijay Yajnik, Nabeel Khan, Marla Dubinsky, Jeffrey Axler, Alexandra James, Brihad Abhyankar, Karen Lasch
INTRODUCTION: The efficacy and safety of vedolizumab, a gut-selective α4β7 integrin antibody, were demonstrated in the GEMINI 1 and GEMINI 2 clinical trials of adults aged 18-80 years. We investigated the efficacy and safety of vedolizumab in patients stratified by age from the GEMINI trials. METHODS: Safety and efficacy, including clinical response, clinical remission, and corticosteroid-free remission, at week 6 and/or 52 were determined post hoc in patients aged <35, 35 to <55, and ≥55 years...
January 9, 2017: Advances in Therapy
Zefang Tang, Chenwei Li, Karena Zhang, Mingyu Yang, Xueda Hu
: The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) projects produced large-scale RNA sequencing data, which provides an opportunity for performing integrated expression analysis for all genes across tens of thousands of tumor and normal tissue specimens. Rapid access to and easy visualization of such valuable data could facilitate research in a wide biological area. Here, we present the GE-mini APP for smart phones, a mobile visualization tool for integrated gene expression data based on both TCGA and GTEx...
January 8, 2017: Bioinformatics
Mohd Younus Ansari, Deepak K Agarwal, Ankur Gupta, Preeti Bhattacharya, Juhi Ansar, Ravi Bhandari
INTRODUCTION: Knowledge about the Shear Bond Strength (SBS) of ceramic brackets with different base design is essential as it affects bond strength to enamel. AIM: The aim of the present study was to evaluate and compare the effect of base designs of different ceramic brackets on SBS, and to determine the fracture site after debonding. MATERIALS AND METHODS: Four groups of ceramic brackets and one group of metal brackets with different base designs were used...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
J Zhang, K Binzel, N C Hall, M Natwa, M I Knopp, M V Knopp
PURPOSE: To evaluate and demonstrate the feasibility of low dose FDG PET in pediatric oncology patients using virtual dose reduction as well as true patients PET/CT scans. METHODS: Wholebody 18F-FDG PET/CT of 39 clinical pediatric patients (0.16±0.06MBq/kg) were scanned on a Gemini TF 64 system at 75±5 min post FDG injection using 3min/bed. Based on the 180s/bed listmode PET data, subsets of total counts in 120s, 90s, 60s, 30s and 15s per bed position were extracted for PET reconstruction to simulate lower dose PET at 2/3th, 1/2th, 1/3th, 1/6th and 1/12th dose levels...
June 2016: Medical Physics
J Zhang, M Natwa, N C Hall, M U Knopp, B Zhang, C Tung, M V Knopp
PURPOSE: The longer patient has to remain on the table during PET imaging, the higher the likelihood of motion artifacts due to patient discomfort. This study was to investigate and optimize PET acquisition overlap in 18F-FDG oncology wholebody PET/CT to speed up PET acquisition and improve patient comfort. METHODS: Wholebody 18F-FDG PET/CT of phantoms, 8 pre-clinical patients (beagles) and 5 clinical oncology patients were performed in 90s/bed on a time-of-flight Gemini TF 64 system...
June 2016: Medical Physics
Xuezhen Wang, Minxiang Zeng, Yi-Hsien Yu, Huiliang Wang, M Sam Mannan, Zhengdong Cheng
Asymmetric Janus and Gemini ZrP-PNIPAM monolayer nanoplatelets were obtained by exfoliation of two-dimensional layered ZrP disks whose surface was covalently modified with thermosensitive polymer PNIPAM. The nanoplatelets largely reduced interfacial tension (IFT) of the oil/water interface so that they were able to produce stable oil/water emulsions, and the PNIPAM grafting either on the surface or the edge endowed the nanoplatelets rapid temperature response. The ZrP-PNIPAM nanoplatelets proved to be thermosensitive Pickering emulsifiers for controlled-release applications...
December 29, 2016: ACS Applied Materials & Interfaces
Zhicheng Pan, Danxuan Fang, Nijia Song, Yuanqing Song, Mingming Ding, Jiehua Li, Feng Luo, Hong Tan, Qiang Fu
Polymeric micelles containing cationic gemini quaternary ammonium (GQA) groups have shown enhanced cellular uptake and efficient drug delivery, while the incorporation of poly(ethylene glycol) (PEG) corona can potentially reduce the absorption of cationic carriers by opsonic proteins and subsequent uptake by mononuclear phagocytic system (MPS). To understand the interactions of GQA and PEG groups and their effects on the biophysicochemical characteristics of nanocarriers, a series of polyurethane micelles containing GQA and different molecular weights of PEG were prepared and carefully characterized...
January 10, 2017: ACS Applied Materials & Interfaces
Huan Liu, Tamara Busch, Steven Eliason, Deepti Anand, Steven Bullard, Lord J J Gowans, Nichole Nidey, Aline Petrin, Eno-Abasi Augustine-Akpan, Irfan Saadi, Martine Dunnwald, Salil A Lachke, Ying Zhu, Adebowale Adeyemo, Brad Amendt, Tony Roscioli, Robert Cornell, Jeffrey Murray, Azeez Butali
BACKGROUND: Recent advances in genomics methodologies, in particular the availability of next-generation sequencing approaches have made it possible to identify risk loci throughout the genome, in particular the exome. In the current study, we present findings from an exome study conducted in five affected individuals of a multiplex family with cleft palate only. METHODS: The GEnome MINIng (GEMINI) pipeline was used to functionally annotate the single nucleotide polymorphisms, insertions and deletions...
December 28, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
Sriteja Mantha, Jesse G McDaniel, Dominic Perroni, Mahesh K Mahanthappa, Arun Yethiraj
Gemini surfactants comprise two single-tailed surfactants connected by a linker at or near the hydrophilic headgroup. They display a variety of water-concentration-dependent lyotropic liquid crystal morphologies that are sensitive to surfactant molecular structure and the nature of the headgroups and counterions. Recently, an interesting dependence of the aqueous-phase behavior on the length of the linker has been discovered; odd-numbered linker length surfactants exhibit characteristically different phase diagrams than even-numbered linker surfactants...
January 17, 2017: Journal of Physical Chemistry. B
Xiaolin Wang, Zhuo Zhang, Yixue Cao, Jingcheng Hao
Thermoreversible ionogels formed by pseudogemini surfactants were prepared in protic ionic liquid, ethylammonium nitrate (EAN). Gemini-type supra-amphiphiles were formed by single-chain surfactants and bola-type molecules in a 2:1M ratio. The structures of aggregates including polymorphous lamellar structures and fibrous networks constituted by multilayer lamellae were determined by optical microscopy observations, transmission electron microscopy (TEM) observations, small-angle X-ray scattering (SAXS) and X-ray diffraction (XRD) measurements...
December 18, 2016: Journal of Colloid and Interface Science
Neda Feizi, Yadollah Yamini, Morteza Moradi, Meghdad Karimi, Qamar Salamat, Hatam Amanzadeh
A new supramolecular solvent (SUPRAS) made up of aggregates of gemini surfactant was introduced. A microextraction method, based on the SUPRAS followed with high performance liquid chromatography-ultraviolet detection, was applied for the determination of parabens in cosmetics, beverages and water samples. A SUPRAS is a nano-structured liquid made up of surfactant aggregates synthesized through a self-assembly process. In the present work, a new gemini-based SUPRAS was introduced. Methyl paraben (MP), ethyl paraben (EP), and propyl paraben (PP) were extracted on the basis of π-cation and Van der Waals interactions into the SUPRAS...
February 8, 2017: Analytica Chimica Acta
Aula Al Muslim, Dana Ayyash, Sarbjeet Singh Gujral, George M Mekhail, Praveen P N Rao, Shawn D Wettig
The effect of variation in the length of surfactant hydrocarbon tail groups was tested in a series of dissymmetric gemini surfactants (N(1)-alkyl N(1),N(1),N(3),N(3)-tetramethyl-N(3)-(6-pyren-6yl)-hexyl)propane-1,3-diammonium dibromide designated as CmC3CnBr, with m = hexyl pyrene, and n = 8, 12, 14, 16, and 18. The aggregation properties of these surfactants have been investigated by means of (1)H NMR, fluorescence spectroscopy, surface tension and electrical conductivity measurements. The critical micelle concentration (CMC) was determined using surface tension and confirmed using the specific conductance method...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
Abdessamad Grirrane, Eleuterio Alvarez, Hermenegildo García, Avelino Corma
Tremorine and precursors of Gemini surfactants have been synthesized in one pot, three-steps, double catalytic A3- coupling reaction and characterized by structural and spectroscopic properties. Cationic [Au(I)-L1][SbF6] complex is more active catalyst compared to neutral L2 and L3- Au(I)- [bis(trifluoromethanesulfonyl)imidate] complexes (L1, L2 = Buchwald-type biaryl phosphane and L3 = triphenylphosphine) to promote the double A3- coupling of ethynyltrimethylsilane, secondary amine (cyclic, aliphatic or aromatic) and formaldehyde...
December 23, 2016: Chemistry: a European Journal
Deborah Michel, Waleed Mohammed-Saeid, Heather Getson, Caitlin Roy, Masoomeh Poorghorban, Jackson M Chitanda, Ronald Verrall, Ildiko Badea
Novel drug delivery systems are developed to improve the biological behavior of poorly soluble drugs and to improve therapeutic outcomes. In melanoma therapy, the goal is efficient drug delivery and mitigation of drug resistance. Melphalan (Mel), a currently used therapeutic agent for melanoma, requires solvent system for solubilization, leading to poor chemical stability. Moreover, drug resistance often renders the drug inefficient in clinical setting. A novel β-cyclodextrin-modified gemini surfactant (CDgemini) delivery system was developed to incorporate Mel in order to improve its physicochemical and biological behavior...
2016: International Journal of Nanomedicine
Guangyue Bai, Hui Wu, Pengxiao Lou, Yujie Wang, Marieta Nichifor, Kelei Zhuo, Jianji Wang, Margarida Bastos
Understanding the thermodynamics of formation of biocompatible aggregates is a key factor in the bottom up approach to the development of novel types of drug carriers and their structural tuning using small amphiphilic molecules. We chose an anionic amphiphilic and biocompatible polymer that consists of a dextran and grafted cholic acid pendants, randomly distributed along the dextran backbone, with a degree of substitution (DS) of 15 mol% (designated Dex-15CACOONa). The thermodynamics of interaction and phase behavior of mixtures of this polyelectrolyte and a cationic gemini surfactant hexanediyl-α,ω-bis(dodecyldimethylammonium bromide) (C12C6C12Br2) or its monomer surfactant dodecyltrimethylammonium bromide (DTAB) in aqueous solution were characterized by isothermal titration calorimetry (ITC) and turbidity, together with cryogenic transmission electron microscopy (Cryo-TEM)...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
Mohd Akram, Sana Anwar, Imtiyaz Ahmad Bhat, Kabir-Ud-Din
Surfactant-protein mixtures have attracted considerable research interest in recent years at the interface of chemical biology and medicinal chemistry. Herein, the interaction between a green gemini surfactant (C16-E2O-C16) and a redox protein hemoglobin was examined through a series of in vitro experimental techniques with an attempt to provide a comprehensive knowledge of the surfactant-protein binding interactions. Quantitative appraisal of the fluorescence/CV data showed that the binding of C16-E2O-C16 to Hb leads to the formation of thermodynamically favorable non-covalent adduct with 1:1 stoichiometry...
December 14, 2016: International Journal of Biological Macromolecules
Ajay Kumar, Subba Rao Devineni, Shailender Kumar Dubey, Pradeep Kumar, Vishal Srivastava, Girish Ambulgekar, Mohit Jain, Dharmendra Kumar Gupta, Gurmeet Singh, Rajesh Kumar, S G Hiriyanna, Pramod Kumar
Four impurities (Imp-I-IV) were detected using gradient HPLC method in few laboratory batches of acrivastine in the level of 0.03-0.12% and three impurities (Imp-I-III) were found to be known and one (Imp-IV) was unknown. In forced degradation study, the drug is degraded into four degradation products under oxidation and photolytic conditions. Two impurities (Imp-III and -IV) were concurred with process related impurities whereas Imp-V and -VI were identified as new degradation impurities. Based on LC-ESI/MS(n) study, the chemical structures of new impurities were presumed as 1-[(2E)-3-(4-methylphenyl)-3-{6-[(1E)-3-oxobut-1-en-1-yl]pyridin-2-yl}prop-2-en-1-yl]pyrrolidin-1-ium-1-olate (Imp-IV), 1-{[3-(4-methylphenyl)-3-{6-[(1E)-3-oxobut-1-en-1-yl]pyridin-2-yl}oxiran-2-yl]methyl}pyrrolidin-1-ium-1-olate (Imp-V) and 2-[2-(4-methylphenyl)-3-[(1-oxidopyrrolidin-1-ium-1-yl)methyl]oxiran-2-yl]-6-[(1E)-3-oxobut-1-en-1-yl]pyridin-1-ium-1-olate (Imp-VI), and confirmed by their synthesis followed by spectroscopic analysis, IR, NMR ((1)H, (13)C) and mass...
October 17, 2016: Journal of Pharmaceutical and Biomedical Analysis
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