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https://www.readbyqxmd.com/read/28333288/exposure-efficacy-relationships-for-vedolizumab-induction-therapy-in-patients-with-ulcerative-colitis-or-crohn-s-disease
#1
Maria Rosario, Jonathan L French, Nathanael L Dirks, Serap Sankoh, Asit Parikh, Huyuan Yang, Silvio Danese, Jean-Frédéric Colombel, Michael Smyth, William J Sandborn, Brian G Feagan, Walter Reinisch, Bruce E Sands, Miguel Sans, Irving Fox
Background and Aims: A positive relationship between vedolizumab trough serum concentrations and clinical outcomes in patients with ulcerative colitis (UC) or Crohn's disease (CD) has been reported. Here we further explore exposure-efficacy relationships for vedolizumab induction therapy in post hoc analyses of GEMINI study data. Methods: Vedolizumab trough concentrations at Week 6 or 10 were grouped in quartiles and clinical outcome rates calculated. Exposure-efficacy relationships at Week 6 and potential baseline covariate effects were explored using logistic regression and individual predicted cumulative average concentration through Week 6 (Caverage) as exposure measure...
February 17, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28325639/gemini-acs-1-toward-unearthing-the-antithrombotic-therapy-cornerstone-for-acute-coronary-syndromes
#2
Paul A Gurbel, Udaya S Tantry
No abstract text is available yet for this article.
March 17, 2017: Lancet
https://www.readbyqxmd.com/read/28325638/clinically-significant-bleeding-with-low-dose-rivaroxaban-versus-aspirin-in-addition-to-p2y12-inhibition-in-acute-coronary-syndromes-gemini-acs-1-a-double-blind-multicentre-randomised-trial
#3
E Magnus Ohman, Matthew T Roe, P Gabriel Steg, Stefan K James, Thomas J Povsic, Jennifer White, Frank Rockhold, Alexei Plotnikov, Hardi Mundl, John Strony, Xiang Sun, Steen Husted, Michal Tendera, Gilles Montalescot, M Cecilia Bahit, Diego Ardissino, Héctor Bueno, Marc J Claeys, Jose C Nicolau, Jan H Cornel, Shinya Goto, Róbert Gábor Kiss, Ümit Güray, Duk-Woo Park, Christoph Bode, Robert C Welsh, C Michael Gibson
BACKGROUND: Dual antiplatelet therapy (DAPT), aspirin plus a P2Y12 inhibitor, is the standard antithrombotic treatment following acute coronary syndromes. The factor Xa inhibitor rivaroxaban reduced mortality and ischaemic events when added to DAPT, but caused increased bleeding. The safety of a dual pathway antithrombotic therapy approach combining low-dose rivaroxaban (in place of aspirin) with a P2Y12 inhibitor has not been assesssed in acute coronary syndromes. We aimed to assess rivaroxaban 2·5 mg twice daily versus aspirin 100 mg daily, in addition to clopidogrel or ticagrelor (chosen at investigator discretion before randomisation), for patients with acute coronary syndromes started within 10 days after presentation and continued for 6-12 months...
March 17, 2017: Lancet
https://www.readbyqxmd.com/read/28319842/two-dimensional-growth-of-crystalline-nanofiber-fabricated-from-gemini-type-amphiphilic-diamide-derivative-inducing-the-thixotropic-property
#4
Manami Iizuka, Yuto Nakagawa, Kyohei Ohmura, Eiichi Satou, Atsuhiro Fujimori
The formation of a nanofiber morphology at the mesoscopic scale and the molecular-level packing of a gemini-type amphiphilic diamide derivative with two hydrocarbons were investigated from two perspectives. First, it was confirmed that a diamide derivative with two hydrocarbons forms crystalline nanofibers even in a monomolecular layer. The height, thickness, and lattice spacing of the two-dimensional orthorhombic system of this crystalline nanofiber in the monolayer of a diamide derivative with two hydrocarbons are 5, 30, and 0...
March 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28317582/robotic-right-hemicolectomy-analysis-of-108-consecutive-procedures-and-multidimensional-assessment-of-the-learning-curve
#5
Amilcare Parisi, Luca Scrucca, Jacopo Desiderio, Alessandro Gemini, Salvatore Guarino, Francesco Ricci, Roberto Cirocchi, Giorgio Palazzini, Vito D'Andrea, Liliana Minelli, Stefano Trastulli
PURPOSE: Surgeons tend to view the robotic right colectomy (RRC) as an ideal beginning procedure to gain proficiency in robotic general and colorectal surgery. Nevertheless, oncological RRC, especially if performed with intracorporeal ileocolic anastomosis confectioning, cannot be considered a technically easier procedure. The aim of this study was to assess the learning curve of the RRC performed for oncological purposes and to evaluate its safety and efficacy investigating the perioperative and pathology outcomes in the different learning phases...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28300024/development-and-validation-of-a-rapid-lc-ms-ms-method-for-simultaneous-determination-of-kaempferol-and-quercetin-in-thespesia-populnea-extract
#6
Hiteksha Panchal, Mamta B Shah
In this study, a simple and rapid LC with tandem MS method was developed and validated for the simultaneous determination of kaempferol and quercetin in <i>Thespesia populnea</i> extract. The compounds were eluted using a Gemini C18 column (50 × 2.0 mm, 3 μm), with the mobile phase consisting of acetonitrile–0.3% formic acid in water at the flow rate of 0.400 mL/min. The assay exhibited a linear dynamic range of 25–2500 ng/mL for both kaempferol and quercetin. The values for intra- and interday precision and accuracy were well within the generally accepted criteria for analytical methods (<15%)...
March 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28294601/gemini-type-tetraphenylethylene-amphiphiles-containing-12-anen3-and-long-hydrocarbon-chains-as-nonviral-gene-vectors-and-gene-delivery-monitors
#7
Ai-Xiang Ding, Zheng-Li Tan, You-Di Shi, Lin Song, Bing Gong, Zhong-Lin Lu
Four gemini amphiphiles decorated with triazole-[12]aneN3 as the hydrophilic moiety and various long hydrocarbons as hydrophobic moieties, 1-4, were designed to form micelles possessing the aggregation-induced emission (AIE) property for gene delivery and tracing. All four amphiphiles give ultralow critical micelle concentrations, are pH-/photostable and biocompatible, and completely retard the migration of plasmid DNAs at low concentrations. The DNA-binding abilities of the micelles were fully assessed. The coaggregated nanoparticles of 1-4 with DNAs could convert back into AIE micelles...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28266722/development-and-validation-of-a-hplc-uv-method-for-the-simultaneous-determination-of-the-antipsychotics-clozapine-olanzapine-and-quetiapine-several-beta-blockers-and-their-metabolites
#8
Margarete Silva Gracia, Alexandra Köppl, Sandra Unholzer, Ekkehard Haen
A simple, accurate and selective column-switching high performance liquid chromatography (HPLC) method was developed and validated for simultaneous quantification of six beta-blockers (metoprolol MET, timolol TIM, bisoprolol BIS, propranolol PRO, carvedilol CAR and nebivolol NEB), three of their metabolites (α-hydroxy metoprolol α-HMET, N-desisopropyl propranolol DIPRO and 4'-hydroxy carvedilol 4-HCAR), three antipsychotics (olanzapine OLA, clozapine CLO and quetiapine QUE) and three of their metabolites (N-desmethyl olanzapine DMOLA, N-desmethyl clozapine DMCLO and N-desalkyl quetiapine DAQUE) in human serum...
March 7, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28260215/minimum-lesion-detectability-as-a-measure-of-pet-system-performance
#9
Stephen Adler, Jurgen Seidel, Peter Choyke, Michael V Knopp, Katherine Binzel, Jun Zhang, Craig Barker, Shielah Conant, Roberto Maass-Moreno
BACKGROUND: A phantom in combination with an imaging protocol was developed to measure the limit of small lesion detection on different PET systems. Seven small spheres with inner diameters ranging from 3.95 up to 15.43 mm were imaged in a Jaszczak ECT Phantom, in air, in a cold background, and with sphere to background contrast ratios of 15:1 down to 1.88:1. The imaging times varied from 1 to 16 min. The imaging protocol was performed on the Gemini TF and Vereos by Philips, the mCT and HRRT by Siemens, and the Discovery 710 by General Electric...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28251849/rational-design-and-synthesis-of-carboxylate-gemini-surfactants-with-an-excellent-aggregate-behavior-for-nano-la2o3-morphology-controllable-preparation
#10
Xueming Liao, Zhinong Gao, Yan Xia, Fei Niu, Wenzhong Zhai
A series of carboxylate gemini surfactants (CGS, Cn-Φ-Cn, n = 12, 14, 16, 18) with diphenyl ketone as a spacer group were prepared using a simple and feasible synthetic method. These CGS exhibited an excellent surface activity with extremely low critical micelle concentration (CMC) value (approximately 10(-5) mol/L), good performance in reducing surface tension (nearly 30 mN/m), and the ability of molecular self-assembly into different aggregate morphologies via adjusting the concentrations, which is attributed to the introduction of diphenyl ketone and carboxylic acid ammonium salt in the molecular structure...
March 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28225072/copper-treatment-during-storage-reduces-phytophthora-and-halophytophthora-infection-of-zostera-marina-seeds-used-for-restoration
#11
Laura L Govers, Els M van der Zee, Johan P Meffert, Patricia C J van Rijswick, Willem A Man In 't Veld, Jannes H T Heusinkveld, Tjisse van der Heide
Restoration is increasingly considered an essential tool to halt and reverse the rapid decline of vital coastal ecosystems dominated by habitat-forming foundation species such as seagrasses. However, two recently discovered pathogens of marine plants, Phytophthora gemini and Halophytophthora sp. Zostera, can seriously hamper restoration efforts by dramatically reducing seed germination. Here, we report on a novel method that strongly reduces Phytophthora and Halophytophthora infection of eelgrass (Zostera marina) seeds...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208794/qsrr-modeling-for-metabolite-standards-analyzed-by-two-different-chromatographic-columns-using-multiple-linear-regression
#12
Chrysostomi Zisi, Ioannis Sampsonidis, Stella Fasoula, Konstantinos Papachristos, Michael Witting, Helen G Gika, Panagiotis Nikitas, Adriani Pappa-Louisi
Modified quantitative structure retention relationships (QSRRs) are proposed and applied to describe two retention data sets: A set of 94 metabolites studied by a hydrophilic interaction chromatography system under organic content gradient conditions and a set of tryptophan and its major metabolites analyzed by a reversed-phase chromatographic system under isocratic as well as pH and/or simultaneous pH and organic content gradient conditions. According to the proposed modification, an additional descriptor is added to a conventional QSRR expression, which is the analyte retention time, tR(R), measured under the same elution conditions, but in a second chromatographic column considered as a reference one...
February 9, 2017: Metabolites
https://www.readbyqxmd.com/read/28195418/upconversion-nanoparticles-synthesized-by-ultra-short-pulsed-laser-ablation-in-liquid-effect-of-stabilizing-environment
#13
Laura Gemini, Tim Schmitz, Rainer Kling, Stephan Barcikowski, Bilal Gökce
The distinctive feature of upconverting compounds to absorb and emit light in the near-infrared region has made upconverting nanoparticles of great interest in various application fields. Nevertheless, these colloids show highly hydrophobic behavior and therefore the use of a proper stabilizing agent is necessary in most cases. Although few chemical techniques for colloid stabilization are available, it is still difficult to achieve a fully reproducible synthesis method for stable upconverting nanoparticle colloids...
February 14, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28180226/facile-fabrication-of-sudan-red-particle-microcapsules-by-a-polymerizable-gemini-surfactant-and-molecular-assembly-mechanisms
#14
Yaqian Wu, Haike Yan, Xuefeng Shi, Jinben Wang
An efficient method was developed to encapsulate water insoluble organic particles of Sudan red III (SR) in aqueous suspensions by using a polymerizable cationic gemini surfactant, 1,3-bis(N,N-dimethyl-N-cetylammonium)-2-(propylacrylate dibromide) (AGC16). The AGC16 coated SR microcapsules (AGC16@SR) were prepared by absorption of AGC16 on the surface of SR, followed by in situ homopolymerization (PAGC16). Several measurements, including transmission and scanning electron microscopy, isothermal titration calorimetry, zeta potential, electron paramagnetic resonance and small angle X-ray scattering, were performed to determine the adsorption amount of AGC16, and the layer structures and the molecular assembly mechanism in the AGC16@SR and PAGC16@SR systems, respectively...
February 9, 2017: Soft Matter
https://www.readbyqxmd.com/read/28174921/dop026-sustained-remission-with-vedolizumab-in-patients-with-moderately-to-severely-active-ulcerative-colitis-a-gemini-1-post-hoc-analysis-of-week-14-remitters
#15
A Stallmach, B Bokemeyer, J Axler, R Curtis, R Ehehalt, B Feagan, P Geransar, A James, A Kaviya, J M Khalid, D Wolf, S Schreiber
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172706/dop021-long-term-effectiveness-and-safety-of-vedolizumab-in-patients-with-crohn-s-disease-5-year-cumulative-exposure-of-gemini-2-completers-rolling-into-the-gemini-open-label-extension-study
#16
S Vermeire, E V Loftus, J-F Colombel, B Feagan, W Sandborn, B Sands, S Danese, G D'Haens, A Kaser, R Panaccione, D Rubin, I Shafran, S O'Byrne, P Geransar, A Previtali, J M Khalid, A Kaviya
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172630/dop019-effect-of-vedolizumab-treatment-on-extraintestinal-manifestations-in-patients-with-crohn-s-disease-a%C3%A2-gemini-2-post-hoc-analysis
#17
B G Feagan, W J Sandborn, J-F Colombel, S O'Byrne, J M Khalid, N Brayshaw, P Geransar, D T Rubin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172545/p209-long-term-effectiveness-and-safety-of-vedolizumab-in-patients-with-ulcerative-colitis-5-year-cumulative-exposure-of-gemini-1-completers-rolling-into-the-gemini-open-label-extension-study
#18
E V Loftus, J-F Colombel, B Feagan, S Vermeire, W Sandborn, B Sands, S Danese, G D'Haens, A Kaser, R Panaccione, D Rubin, I Shafran, S O'Byrne, P Geransar, A James, A Kaviya, J M Khalid
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28168729/novel-uhplc-ms-ms-method-for-the-determination-of-rotigotine-in-the-plasma-of-patients-with-parkinson-s-disease
#19
Susan Mohamed, Roberto Riva, Manuela Contin
A novel ultra high pressure liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of the dopamine receptor agonist rotigotine in human plasma. Following liquid-liquid extraction with tert-butyl methyl ether from 500 μL plasma, the chromatographic analysis was performed on a Gemini NX3 column using 5 mM pH 5.0 ammonium acetate/5 mM ammonium acetate in methanol as binary gradient mobile phase, at a flow rate of 0.3 mL/min. The MS/MS ion transitions were 316...
February 6, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28139691/the-hypothalamic-npvf-circuit-modulates-ventral-raphe-activity-during-nociception
#20
Romain Madelaine, Matthew Lovett-Barron, Caroline Halluin, Aaron S Andalman, Jin Liang, Gemini M Skariah, Louis C Leung, Vanessa M Burns, Philippe Mourrain
RFamide neuropeptide VF (NPVF) is expressed by neurons in the hypothalamus and has been implicated in nociception, but the circuit mechanisms remain unexplored. Here, we studied the structural and functional connections from NPVF neurons to downstream targets in the context of nociception, using novel transgenic lines, optogenetics, and calcium imaging in behaving larval zebrafish. We found a specific projection from NPVF neurons to serotonergic neurons in the ventral raphe nucleus (vRN). We showed NPVF neurons and vRN are suppressed and excited by noxious stimuli, respectively...
January 31, 2017: Scientific Reports
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