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https://www.readbyqxmd.com/read/28428717/minimally-invasive-surgery-for-gastric-cancer-a-comparison-between-robotic-laparoscopic-and-open-surgery
#1
Amilcare Parisi, Daniel Reim, Felice Borghi, Ninh T Nguyen, Feng Qi, Andrea Coratti, Fabio Cianchi, Maurizio Cesari, Francesca Bazzocchi, Orhan Alimoglu, Johan Gagnière, Graziano Pernazza, Simone D'Imporzano, Yan-Bing Zhou, Juan-Santiago Azagra, Olivier Facy, Steven T Brower, Zhi-Wei Jiang, Lu Zang, Arda Isik, Alessandro Gemini, Stefano Trastulli, Alexander Novotny, Alessandra Marano, Tong Liu, Mario Annecchiarico, Benedetta Badii, Giacomo Arcuri, Andrea Avanzolini, Metin Leblebici, Denis Pezet, Shou-Gen Cao, Martine Goergen, Shu Zhang, Giorgio Palazzini, Vito D'Andrea, Jacopo Desiderio
AIM: To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes. METHODS: This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy (RG), laparoscopic gastrectomy (LG), open gastrectomy (OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate...
April 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28415837/effects-of-a-spacer-on-the-phase-behavior-of-gemini-surfactants-in-ethanolammonium-nitrate
#2
Qintang Li, Meihuan Yao, Xiu Yue, Xiao Chen
The aggregation behavior of quaternary ammonium gemini surfactants (12-s-12) in a protic ionic liquid, ethanolammonium nitrate (EOAN), was investigated by small-angle X-ray scattering, freeze-fracture transmission electron microscopy, polarized optical microscopy, and rheological measurements. The rarely reported nonaqueous two phases in the ionic liquid were observed at lower 12-s-12 concentrations. The upper phase was composed of micelles, whereas only the surfactant unimers or multimers were detected in the low phase...
April 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28409852/tandem-mass-spectrometric-analysis-of-novel-peptide-modified-gemini-surfactants-used-as-gene-delivery-vectors
#3
Mays Al-Dulaymi, Anas El-Aneed
Diquaternary ammonium gemini Surfactants have emerged as effective gene delivery vectors. A novel series of eleven peptide-modified compounds was synthesized, showing promising results in delivering genetic materials. The purpose of this work is to elucidate the tandem mass spectrometric (MS/MS) dissociation behaviour of these novel molecules establishing a generalized MS/MS fingerprint. Exact mass measurements were achieved using a hybrid quadrupole orthogonal time-of-flight mass spectrometer (QqToF-MS) and a multi-stage tandem mass spectrometric analysis was conducted using a triple quadrupole-linear ion trap mass spectrometer (QqQLIT-MS)...
April 14, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28407589/transport-of-anionic-azo-dyes-from-aqueous-solution-to-gemini-surfactant-modified-wheat-bran-synchrotron-infrared-molecular-interaction-and-adsorption-studies
#4
Yan Zhang, Guohe Huang, Chunjiang An, Xiaying Xin, Xia Liu, Maya Raman, Yao Yao, Wenxia Wang, Mukesh Doble
From the view of economic efficiency and technology sustainability, biomass adsorbent has a high potential for pollution control. In the present study, the performance of gemini 12-2-12 surfactant-modified wheat bran (MWB) for the removal of anionic azo dyes from aqueous solution was investigated. A new insight was gained into the modification mechanism through synchrotron-assisted infrared analysis and molecular interaction simulation. The equilibrium and kinetic studies for the adsorption of Acid Red 18 (AR-18), Acid Orange 7 (AO-7) and Acid Black 1 (AB-1) on MWB were conducted...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28393936/effect-of-counterions-on-the-micellization-and-monolayer-behaviour-of-cationic-gemini-surfactants
#5
M S Islam, S M Shortall, G M Mekhail, S P Callender, O Madkhali, Z Bharwani, D Ayyash, K Kobernyk, S D Wettig
The effect of various inorganic and organic counterions on the aggregation behavior of gemini surfactants was examined to investigate the dominant influence of the anions on their micellization and aggregation behavior. This study included eight ethanediyl-α,ω-bis-(dimethylhexadecylammonium) gemini surfactants (GS, also known as 16-2-16) having counterions of chloride (Cl(-)), bromide (Br(-)), malate, tartrate, adenosine monophosphate (AMP), guanosine monophosphate (GMP), cytidine monophosphate (CMP), and uridine monophosphate (UMP)...
April 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28387417/microscale-coiling-in-bis-imidazolium-supramolecular-hydrogel-fibres-induced-by-the-release-of-a-cationic-serine-protease-inhibitor
#6
David Limón, Claire Jiménez-Newman, Ana C Calpena, Arántzazu González-Campo, David B Amabilino, Lluïsa Pérez-García
Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.
April 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28369329/vedolizumab-induces-long-term-mucosal-healing-in-patients-with-crohn-s-disease-and-ulcerative-colitis
#7
Maja Noman, Marc Ferrante, Raf Bisschops, Gert De Hertogh, Karolien Van den Broeck, Karen Rans, Paul J Rutgeerts, Séverine Vermeire, Gert Van Assche
Introduction.: Vedolizumab has proven efficacy in IBD, but long term mucosal healing in Crohn's disease (CD), as well as the incidence of colorectal neoplasia in IBD, among patients treated with vedolizumab have not been studied. We aimed to document mucosal healing and to explore the risk of colorectal neoplasia with vedolizumab maintenance therapy. Methods.: Surveillance colonoscopy was prospectively scheduled for patients with longstanding UC or CD at a tertiary referral center in the open label extension phase (vedolizumab 300 mg IV q 4 wks) of the Gemini studies (GEMINI LTS, study number NCT00790933)...
March 24, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28359893/spectroscopic-studies-on-the-gemini-surfactant-mediated-refolding-of-human-serum-albumin
#8
Nuzhat Gull, Javed Masood Khan, Rukhsana, Rizwan Hassan Khan
Refolding of guanidinium hydrochloride (GdCl) denatured human serum albumin (HSA) using a combination of cationic gemini surfactants; pentanediyl-α,ω-bis(cetyldimethylammonium bromide) (C16H33(CH3)2N(+)-(CH2)5-N(+)(CH3)2C16H33)2Br(-) designated as G5 and methyl- β-cyclodextrin, is attempted in the present study. The studies were carried out in an aqueous medium (pH 7.4) using dynamic light scattering (DLS), circular dichroism (CD) and fluorescence spectroscopy. A careful study of the DLS data indicates that against the hydrodynamic radius (Rh) of 3...
March 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28333288/exposure-efficacy-relationships-for-vedolizumab-induction-therapy-in-patients-with-ulcerative-colitis-or-crohn-s-disease
#9
Maria Rosario, Jonathan L French, Nathanael L Dirks, Serap Sankoh, Asit Parikh, Huyuan Yang, Silvio Danese, Jean-Frédéric Colombel, Michael Smyth, William J Sandborn, Brian G Feagan, Walter Reinisch, Bruce E Sands, Miguel Sans, Irving Fox
Background and Aims: A positive relationship between vedolizumab trough serum concentrations and clinical outcomes in patients with ulcerative colitis (UC) or Crohn's disease (CD) has been reported. Here we further explore exposure-efficacy relationships for vedolizumab induction therapy in post hoc analyses of GEMINI study data. Methods: Vedolizumab trough concentrations at Week 6 or 10 were grouped in quartiles and clinical outcome rates calculated. Exposure-efficacy relationships at Week 6 and potential baseline covariate effects were explored using logistic regression and individual predicted cumulative average concentration through Week 6 (Caverage) as exposure measure...
February 17, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28325639/gemini-acs-1-toward-unearthing-the-antithrombotic-therapy-cornerstone-for-acute-coronary-syndromes
#10
Paul A Gurbel, Udaya S Tantry
No abstract text is available yet for this article.
March 17, 2017: Lancet
https://www.readbyqxmd.com/read/28325638/clinically-significant-bleeding-with-low-dose-rivaroxaban-versus-aspirin-in-addition-to-p2y12-inhibition-in-acute-coronary-syndromes-gemini-acs-1-a-double-blind-multicentre-randomised-trial
#11
E Magnus Ohman, Matthew T Roe, P Gabriel Steg, Stefan K James, Thomas J Povsic, Jennifer White, Frank Rockhold, Alexei Plotnikov, Hardi Mundl, John Strony, Xiang Sun, Steen Husted, Michal Tendera, Gilles Montalescot, M Cecilia Bahit, Diego Ardissino, Héctor Bueno, Marc J Claeys, Jose C Nicolau, Jan H Cornel, Shinya Goto, Róbert Gábor Kiss, Ümit Güray, Duk-Woo Park, Christoph Bode, Robert C Welsh, C Michael Gibson
BACKGROUND: Dual antiplatelet therapy (DAPT), aspirin plus a P2Y12 inhibitor, is the standard antithrombotic treatment following acute coronary syndromes. The factor Xa inhibitor rivaroxaban reduced mortality and ischaemic events when added to DAPT, but caused increased bleeding. The safety of a dual pathway antithrombotic therapy approach combining low-dose rivaroxaban (in place of aspirin) with a P2Y12 inhibitor has not been assesssed in acute coronary syndromes. We aimed to assess rivaroxaban 2·5 mg twice daily versus aspirin 100 mg daily, in addition to clopidogrel or ticagrelor (chosen at investigator discretion before randomisation), for patients with acute coronary syndromes started within 10 days after presentation and continued for 6-12 months...
March 17, 2017: Lancet
https://www.readbyqxmd.com/read/28319842/two-dimensional-growth-of-crystalline-nanofiber-fabricated-from-gemini-type-amphiphilic-diamide-derivative-inducing-the-thixotropic-property
#12
Manami Iizuka, Yuto Nakagawa, Kyohei Ohmura, Eiichi Satou, Atsuhiro Fujimori
The formation of a nanofiber morphology at the mesoscopic scale and the molecular-level packing of a gemini-type amphiphilic diamide derivative with two hydrocarbons were investigated from two perspectives. First, it was confirmed that a diamide derivative with two hydrocarbons forms crystalline nanofibers even in a monomolecular layer. The height, thickness, and lattice spacing of the two-dimensional orthorhombic system of this crystalline nanofiber in the monolayer of a diamide derivative with two hydrocarbons are 5, 30, and 0...
March 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28317582/robotic-right-hemicolectomy-analysis-of-108-consecutive-procedures-and-multidimensional-assessment-of-the-learning-curve
#13
Amilcare Parisi, Luca Scrucca, Jacopo Desiderio, Alessandro Gemini, Salvatore Guarino, Francesco Ricci, Roberto Cirocchi, Giorgio Palazzini, Vito D'Andrea, Liliana Minelli, Stefano Trastulli
PURPOSE: Surgeons tend to view the robotic right colectomy (RRC) as an ideal beginning procedure to gain proficiency in robotic general and colorectal surgery. Nevertheless, oncological RRC, especially if performed with intracorporeal ileocolic anastomosis confectioning, cannot be considered a technically easier procedure. The aim of this study was to assess the learning curve of the RRC performed for oncological purposes and to evaluate its safety and efficacy investigating the perioperative and pathology outcomes in the different learning phases...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28300024/development-and-validation-of-a-rapid-lc-ms-ms-method-for-simultaneous-determination-of-kaempferol-and-quercetin-in-thespesia-populnea-extract
#14
Hiteksha Panchal, Mamta B Shah
In this study, a simple and rapid LC with tandem MS method was developed and validated for the simultaneous determination of kaempferol and quercetin in <i>Thespesia populnea</i> extract. The compounds were eluted using a Gemini C18 column (50 × 2.0 mm, 3 μm), with the mobile phase consisting of acetonitrile–0.3% formic acid in water at the flow rate of 0.400 mL/min. The assay exhibited a linear dynamic range of 25–2500 ng/mL for both kaempferol and quercetin. The values for intra- and interday precision and accuracy were well within the generally accepted criteria for analytical methods (<15%)...
March 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28294601/gemini-type-tetraphenylethylene-amphiphiles-containing-12-anen3-and-long-hydrocarbon-chains-as-nonviral-gene-vectors-and-gene-delivery-monitors
#15
Ai-Xiang Ding, Zheng-Li Tan, You-Di Shi, Lin Song, Bing Gong, Zhong-Lin Lu
Four gemini amphiphiles decorated with triazole-[12]aneN3 as the hydrophilic moiety and various long hydrocarbons as hydrophobic moieties, 1-4, were designed to form micelles possessing the aggregation-induced emission (AIE) property for gene delivery and tracing. All four amphiphiles give ultralow critical micelle concentrations, are pH-/photostable and biocompatible, and completely retard the migration of plasmid DNAs at low concentrations. The DNA-binding abilities of the micelles were fully assessed. The coaggregated nanoparticles of 1-4 with DNAs could convert back into AIE micelles...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28266722/development-and-validation-of-a-hplc-uv-method-for-the-simultaneous-determination-of-the-antipsychotics-clozapine-olanzapine-and-quetiapine-several-beta-blockers-and-their-metabolites
#16
Margarete Silva Gracia, Alexandra Köppl, Sandra Unholzer, Ekkehard Haen
A simple, accurate and selective column-switching high performance liquid chromatography (HPLC) method was developed and validated for simultaneous quantification of six beta-blockers (metoprolol MET, timolol TIM, bisoprolol BIS, propranolol PRO, carvedilol CAR and nebivolol NEB), three of their metabolites (α-hydroxy metoprolol α-HMET, N-desisopropyl propranolol DIPRO and 4'-hydroxy carvedilol 4-HCAR), three antipsychotics (olanzapine OLA, clozapine CLO and quetiapine QUE) and three of their metabolites (N-desmethyl olanzapine DMOLA, N-desmethyl clozapine DMCLO and N-desalkyl quetiapine DAQUE) in human serum...
March 7, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28260215/minimum-lesion-detectability-as-a-measure-of-pet-system-performance
#17
Stephen Adler, Jurgen Seidel, Peter Choyke, Michael V Knopp, Katherine Binzel, Jun Zhang, Craig Barker, Shielah Conant, Roberto Maass-Moreno
BACKGROUND: A phantom in combination with an imaging protocol was developed to measure the limit of small lesion detection on different PET systems. Seven small spheres with inner diameters ranging from 3.95 up to 15.43 mm were imaged in a Jaszczak ECT Phantom, in air, in a cold background, and with sphere to background contrast ratios of 15:1 down to 1.88:1. The imaging times varied from 1 to 16 min. The imaging protocol was performed on the Gemini TF and Vereos by Philips, the mCT and HRRT by Siemens, and the Discovery 710 by General Electric...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28251849/rational-design-and-synthesis-of-carboxylate-gemini-surfactants-with-an-excellent-aggregate-behavior-for-nano-la2o3-morphology-controllable-preparation
#18
Xueming Liao, Zhinong Gao, Yan Xia, Fei Niu, Wenzhong Zhai
A series of carboxylate gemini surfactants (CGS, Cn-Φ-Cn, n = 12, 14, 16, 18) with diphenyl ketone as a spacer group were prepared using a simple and feasible synthetic method. These CGS exhibited an excellent surface activity with extremely low critical micelle concentration (CMC) value (approximately 10(-5) mol/L), good performance in reducing surface tension (nearly 30 mN/m), and the ability of molecular self-assembly into different aggregate morphologies via adjusting the concentrations, which is attributed to the introduction of diphenyl ketone and carboxylic acid ammonium salt in the molecular structure...
March 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28225072/copper-treatment-during-storage-reduces-phytophthora-and-halophytophthora-infection-of-zostera-marina-seeds-used-for-restoration
#19
Laura L Govers, Els M van der Zee, Johan P Meffert, Patricia C J van Rijswick, Willem A Man In 't Veld, Jannes H T Heusinkveld, Tjisse van der Heide
Restoration is increasingly considered an essential tool to halt and reverse the rapid decline of vital coastal ecosystems dominated by habitat-forming foundation species such as seagrasses. However, two recently discovered pathogens of marine plants, Phytophthora gemini and Halophytophthora sp. Zostera, can seriously hamper restoration efforts by dramatically reducing seed germination. Here, we report on a novel method that strongly reduces Phytophthora and Halophytophthora infection of eelgrass (Zostera marina) seeds...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208794/qsrr-modeling-for-metabolite-standards-analyzed-by-two-different-chromatographic-columns-using-multiple-linear-regression
#20
Chrysostomi Zisi, Ioannis Sampsonidis, Stella Fasoula, Konstantinos Papachristos, Michael Witting, Helen G Gika, Panagiotis Nikitas, Adriani Pappa-Louisi
Modified quantitative structure retention relationships (QSRRs) are proposed and applied to describe two retention data sets: A set of 94 metabolites studied by a hydrophilic interaction chromatography system under organic content gradient conditions and a set of tryptophan and its major metabolites analyzed by a reversed-phase chromatographic system under isocratic as well as pH and/or simultaneous pH and organic content gradient conditions. According to the proposed modification, an additional descriptor is added to a conventional QSRR expression, which is the analyte retention time, tR(R), measured under the same elution conditions, but in a second chromatographic column considered as a reference one...
February 9, 2017: Metabolites
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