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https://www.readbyqxmd.com/read/29353162/monolayers-of-a-tetrazine-containing-gemini-amphiphile-interplays-with-biomembrane-lipids
#1
Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata
The property of a newly synthesized tetrazine derivative comprised of double C18-saturated hydrocarbon chain (C18-rTz-C18) has been studied in situ at the air-water interface. C18-rTz-C18 or a gemini amphiphile contributes to restriction of its tetrazine moiety on the interface, which is expected to be used for bioimaging and analytical reagents. Herein, to understand lateral interactions between Tz and biomembrane constituents, we investigated the interfacial behavior of Langmuir monolayers composed of C18-rTz-C18 and biomembrane lipids such as DPPC, DPPG, DPPE, PSM, and Cholesterol (Ch)...
January 17, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29350229/aggregate-evolution-in-aqueous-solutions-of-a-gemini-surfactant-derived-from-dehydroabietic-acid
#2
Lin Feng, Danhua Xie, Binglei Song, Jiayu Zhang, Xiaomei Pei, Zhenggang Cui
Innovations in surfactant structure are a feasible way to probe molecular self-assembly principles. Herein, the solution behaviour of a newly synthesized Gemini surfactant derived from dehydroabietic acid, abbreviated R-(EO)-E-R, was investigated using surface tension, fluorescence, isothermal titration calorimetry (ITC), rheology, freeze-fracture transmission electron microscopy (FF-TEM) and cryogenic transmission electron microscopy (cryo-TEM) methods. R-(EO)-E-R has two large, rigid hydrophobic groups. At low concentrations, R-(EO)-E-R forms micelles with an aggregation number of approximately 10, which is smaller than those of Gemini surfactants containing flexible alkyl tails...
January 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29340416/self-assembly-of-cationic-gemini-surfactants-alkanediyl-bis-dimethyldodecyl-ammonium-bromide-in-cyclohexane-effects-of-spacer-length-on-their-association-into-reverse-lyotropic-liquid-crystalline-or-reverse-vesicles
#3
Shenglu Deng, Jianxi Zhao
Herein, homogeneous solutions of cationic gemini surfactants, alkanediyl-α,ω-bis(dimethyldodecylammonium bromide), referred to as 12-s-12 where s = 2, 4, 6, 8, and 10, in cyclohexane have been prepared with the help of sodium hexanoate (SH) or sodium laurate (SL). These surfactants self-assembled in cyclohexane to form various aggregating structures, which were characterised by small-angle X-ray scattering (SAXS) together with polarised microscopy observations. The results showed that 12-2-12/SH, where the gemini had the shortest spacer among this series, formed an inverse micellar cubic liquid crystalline phase of the Fd3m structure...
January 17, 2018: Soft Matter
https://www.readbyqxmd.com/read/29334109/a-multifunctional-supramolecular-hydrogel-preparation-properties-and-molecular-assembly
#4
Lin Wang, Xuefeng Shi, Yaqian Wu, Jian Zhang, Yuejun Zhu, Jinben Wang
A novel supramolecular hydrogel was designed and constructed by molecular self-assembly of a cationic gemini surfactant, 1,3-bis(N,N-dimethyl-N-cetylammonium)-2-propylacrylate dibromide (AGC16), and an anionic aromatic compound, trisodium 1,3,6-naphthalenetrisulfonate (NTS). Owing to its unique structure, the hydrogel (abbreviated as AGC16/NTS) has the potential to be used as a multifunctional drug delivery system. The structure and properties of AGC16/NTS were characterized by rheological measurements, differential scanning calorimetry, variable-temperature 1H nuclear magnetic resonance, ultraviolet-visible spectroscopy, variable-temperature fluorescence emission spectroscopy, cryogenic scanning electron microscopy, transmission electron microscopy and X-ray diffraction methods...
January 15, 2018: Soft Matter
https://www.readbyqxmd.com/read/29319234/comparative-pharmacokinetics-of-trandolapril-its-active-metabolite-and-verapamil-in-human-plasma-of-egyptian-population-using-hplc-ms-ms
#5
Ragaa Magdy, Ahmed H El-Khatib, Ahmed Hemdan, Omar Abd Elaziz, Maha Farouk, Michael W Linscheid
Trandolapril and verapamil are commonly used antihypertensive drugs. However, there is a lack of available data on the change of their pharmacokinetics in patients with liver or kidney impairment and hence the need for dose adjustment. In the presented work, a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the monitoring of trandolapril, its active metabolite trandolaprilat, and verapamil in human plasma of patients with renal impairment and/or liver insufficiency...
January 10, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29319220/drug-induced-micelle-to-vesicle-transition-of-a-cationic-gemini-surfactant-potential-applications-in-drug-delivery
#6
Sargam M Rajput, Sugam Kumar, Vinod K Aswal, Omar El Seoud, Naved Anjum I Malek, Suresh Kumar Kailasa
The impetus for the sustained interest in the formation of vesicles is their potential application as efficient drug delivery systems. A simple approach for ionic surfactants is to add a vesicle-inducing drug of opposite charge. In ionic gemini surfactants (GS) two molecules are covalently linked with a "spacer". Considering drug-delivery, GS are more attractive candidates than their single-chain counterparts because of their high surface activity and the effect on the physico-chemical properties of their solutions caused by changing the length of the spacer, and inclusion of heteroatoms therein...
January 10, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29301932/a-post-reconstruction-harmonization-method-for-multicenter-radiomic-studies-in-pet
#7
Fanny Orlhac, Sarah Boughdad, Cathy Philippe, Hugo Stalla-Bourdillon, Christophe Nioche, Laurence Champion, Michaël Soussan, Frédérique Frouin, Vincent Frouin, Irène Buvat
Introduction: Several reports have shown that radiomic feature values are affected by the acquisition and reconstruction parameters, thus hampering multicenter studies. We propose a method to standardize features measured from Positron Emission Tomography (PET) images obtained using different imaging protocols to remove the center effect while preserving patient-specific effects. Methods: Pre-treatment 18F-FDG-PET images of patients with breast cancer were included. In Department A, 63 patients were scanned using a Gemini Time-Of-Flight-PET/Computed-Tomography scanner including 16 triple-negative lesions (TN)...
January 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29260846/soft-particles-of-gemini-surfactant-conjugated-polymer-for-enhanced-anticancer-activity-of-chemotherapeutics
#8
Hua Wang, Weiwei Zhao, Lingyun Zhou, Jianwu Wang, Libing Liu, Shu Wang, Yilin Wang
In this work, we developed a kind of novel nontoxic soft particle self-assembled by gemini surfactant (SDHC) and conjugated polymer (PMNT). The soft particle shows strong ability in incorporating into cell membrane, and alters the membrane permeability, especially under light irradiation. The anticancer activities of doxorubicin (DOX) are enhanced 6 to 9 times after cancer cells were treated with the soft particles under light irradiation. The cell viabilities of three kinds of cancer cells testify that this effect of the soft particles on chemotherapy is universal...
December 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29258369/high-treatment-persistence-rate-and-significant-endoscopic-healing-among-real-life-patients-treated-with-vedolizumab-a-finnish-nationwide-inflammatory-bowel-disease-cohort-study-finvedo
#9
Tero Ylisaukko-Oja, Jaakko Aaltonen, Heikki Nuutinen, Timo Blomster, Airi Jussila, Markku Pajala, Kimmo Salminen, Veikko Moilanen, Kalle Hakala, Mikko Kellokumpu, Kari Toljamo, Henna Rautiainen, Juha Kuisma, Markku Peräaho, Pauliina Molander, Jouni Silvennoinen, Ville Liukkonen, Hans Henricson, Jyrki Tillonen, Mirva Esterinen, Christian Nielsen, Eija Hirsi, Margus Lääne, Ulla-Maija Suhonen, Ilkka Vihriälä, Petri Mäkelä, Mika Puhto, Jari Punkkinen, Hannu Sulonen, Sauli Herrala, Jari Jokelainen, Klaus Tamminen, Taina Sipponen
OBJECTIVES: The efficacy and tolerability of vedolizumab in the treatment of inflammatory bowel diseases (IBD) has been demonstrated in an extensive GEMINI clinical trial programme. Clinical trials represent highly selected patient populations and, therefore, it is important to demonstrate effectiveness in real-life clinical practice. We set out to assess real-world treatment outcomes of vedolizumab in a nationwide cohort of treatment refractory Finnish Crohn's disease (CD) and ulcerative colitis (UC) patients...
December 19, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29247338/diverse-replication-associated-protein-encoding-circular-dna-viruses-in-guano-samples-of-central-eastern-european-bats
#10
Gábor Kemenesi, Kornélia Kurucz, Brigitta Zana, Fanni Földes, Péter Urbán, Anton Vlaschenko, Kseniia Kravchenko, Ivana Budinski, Farkas Szodoray-Parádi, Szilárd Bücs, Csaba Jére, István Csősz, Abigél Szodoray-Parádi, Péter Estók, Tamás Görföl, Sándor Boldogh, Ferenc Jakab
Circular replication-associated protein encoding single-stranded DNA (CRESS DNA) viruses are increasingly recognized worldwide in a variety of samples. Representative members include well-described veterinary pathogens with worldwide distribution, such as porcine circoviruses or beak and feather disease virus. In addition, numerous novel viruses belonging to the family Circoviridae with unverified pathogenic roles have been discovered in different human samples. Viruses of the family Genomoviridae have also been described as being highly abundant in different faecal and environmental samples, with case reports showing them to be suspected pathogens in human infections...
December 15, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29237706/patient-characteristics-resource-use-and-outcomes-associated-with-general-internal-medicine-hospital-care-the-general-medicine-inpatient-initiative-gemini-retrospective-cohort-study
#11
Amol A Verma, Yishan Guo, Janice L Kwan, Lauren Lapointe-Shaw, Shail Rawal, Terence Tang, Adina Weinerman, Peter Cram, Irfan A Dhalla, Stephen W Hwang, Andreas Laupacis, Muhammad M Mamdani, Steven Shadowitz, Ross Upshur, Robert J Reid, Fahad Razak
BACKGROUND: The precise scope of hospital care delivered under general internal medicine services remains poorly quantified. The purpose of this study was to describe the demographic characteristics, medical conditions, health outcomes and resource use of patients admitted to general internal medicine at 7 hospital sites in the Greater Toronto Area. METHODS: This was a retrospective cohort study involving all patients who were admitted to or discharged from general internal medicine at the study sites between Apr...
December 11, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29230440/n-gemini-peptides-cytosolic-protease-resistance-via-n-terminal-dimerization-of-unstructured-peptides
#12
Effrat L Fayer, William M Gilliland, J Michael Ramsey, Nancy L Allbritton, Marcey L Waters
Herein we describe a synthetically simple strategy for increasing the lifetime of unstructured peptides in cytosolic environment via dimerization at the N-terminus to block threading into the catalytic cleft of cytosolic proteases. We establish this approach with kinase substrates, allowing for phosphorylation in cells as a demonstration of protease resistance.
December 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29227659/cationic-gemini-surfactant-plasmid-deoxyribonucleic-acid-condensates-as-a-single-amphiphilic-entity
#13
Samantha Marisha Shortall, Shawn D Wettig
A critical aggregate concentration for the surfactant-DNA "complex" or "condensate" consisting of the 16-3-16 gemini surfactant and circular plasmid DNA was determined using surface tensiometry, dynamic light scattering and conductometry. This surfactant-DNA complex acts as an amphiphile itself, for example, decreasing the surface tension of water until a critical concentration is reached. The evidence presented here introduces a new way of thinking about these surfactant-DNA condensates - not simply as aggregates in solution, but as surface active agents in their own right...
December 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29223327/restoration-of-motor-function-after-operative-reconstruction-of-the-acutely-transected-spinal-cord-in-the-canine-model
#14
Zehan Liu, Shuai Ren, Kuang Fu, Qiong Wu, Jun Wu, Liting Hou, Hong Pan, Linlin Sun, Jian Zhang, Bingjian Wang, Qing Miao, Guiyin Sun, Vincenzo Bonicalzi, Sergio Canavero, Xiaoping Ren
BACKGROUND: Cephalosomatic anastomosis or what has been called a "head transplantation" requires full reconnection of the respective transected ends of the spinal cords. The GEMINI spinal cord fusion protocol has been developed for this reason. Here, we report the first randomized, controlled study of the GEMINI protocol in large animals. METHODS: We conducted a randomized, controlled study of a complete transection of the spinal cord at the level of T10 in dogs at Harbin Medical University, Harbin, China...
December 6, 2017: Surgery
https://www.readbyqxmd.com/read/29191606/response-rates-to-single-agent-chemotherapy-after-exposure-to-immune-checkpoint-inhibitors-in-advanced-non-small-cell-lung-cancer
#15
Gustavo Schvartsman, S Andrew Peng, Giorgios Bis, J Jack Lee, Marcelo F K Benveniste, Jianjun Zhang, Emily B Roarty, Lara Lacerda, Stephen Swisher, John V Heymach, Frank V Fossella, William N William
INTRODUCTION: Exploratory analysis of clinical trials in various tumor types have demonstrated potential improvements in overall response rate (ORR) to chemotherapy after exposure to vaccine-based immunotherapy. The objective of this retrospective study was to determine if single-agent chemotherapy (3rd-line or beyond) would yield improved ORR when given after exposure to programmed death-(ligand)1 inhibitors (anti-PD1) in metastatic non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We queried the Thoracic GEMINI database of MD Anderson Cancer Center for patients treated between 06/12 and 11/16 who received at least one single-agent chemotherapy as 3rd-line or beyond, following progression after platinum-based chemotherapy and anti-PD1...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29165338/action-of-monomeric-gemini-surfactants-on-free-cells-and-biofilm-of-asaia-lannensis
#16
Anna Koziróg, Dorota Kręgiel, Bogumił Brycki
We investigated the biological activity of surfactants based on quaternary ammonium compounds: gemini surfactant hexamethylene-1,6-bis-(N,N-dimethyl-N-dodecylammonium bromide) (C6), synthesized by the reaction of N,N-dimethyl-N-dodecylamine with 1,6-dibromohexane, and its monomeric analogue dodecyltrimethylammonium bromide (DTAB). The experiments were performed with bacteria Asaia lannensis, a common spoilage in the beverage industry. The minimal inhibitory concentration (MIC) values were determined using the tube standard two-fold dilution method...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29160329/effects-of-length-and-hydrophilicity-hydrophobicity-of-diamines-on-self-assembly-of-diamine-sds-gemini-like-surfactants
#17
Zhidi Chen, Jeffrey Penfold, Peixun Li, James Doutch, Yaxun Fan, Yilin Wang
This work studied gemini-like surfactants formed from anionic surfactant sodium dodecyl sulfate (SDS) and cationic charged bola-type diamines with hydrophilic or hydrophobic spacers of different lengths using surface tension, small angle neutron scattering, isothermal titration microcalorimetry and cryogenic transmission electron microscopy. The critical micelle concentrations (CMC) and the surface tension at CMC (γCMC) for all the diamine/SDS mixtures are markedly lower than that of SDS. The shorter diamines reduce γCMC to a greater extent regardless of the hydrophilicity/hydrophobicity of the diamines...
November 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/29154882/interaction-of-novel-twin-tailed-oxy-diester-functionalized-surfactant-with-lysozyme-spectroscopic-and-computational-perspective
#18
Imtiyaz Ahmad Bhat, Waseem Feeroze Bhat, Mohd Akram, Kabir-Ud-Din
Herein, we have examined the interaction of oxy-diester novel twin tailed (gemini) surfactant, 2,2(')-[(oxybis(ethane-1,2-diyl))bis(oxy)]bis(N-hexadecyl-N,Ndimethyl-2-oxoethanaminium) dichloride (C16-E2O-C16) with hen egg white lysozyme (HEWL), utilizing a spectroscopic and molecular docking techniques. Steady-state fluorescence infers ground state C16-E2O-C16-HEWL complex formation. Other spectroscopic results validated the conformational, structural and micro-environmental changes in HEWL upon interaction with C16-E2O-C16...
November 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29140943/antibodies-toward-vedolizumab-appear-from-the-first-infusion-onward-and-disappear-over-time
#19
Sumin Bian, Erwin Dreesen, Ho Tsun Tang, Griet Compernolle, Miet Peeters, Gert Van Assche, Marc Ferrante, Séverine Vermeire, Ann Gils
BACKGROUND: Vedolizumab (VDZ) has been approved for the treatment of patients with moderate-to-severe Crohn's disease and ulcerative colitis. The GEMINI trials reported a low prevalence of anti-VDZ antibodies (AVA). However, the AVA assays used in GEMINI were drug sensitive, resulting in a possible underestimation of the rate of AVA formation. This study aimed to monitor immunogenicity of VDZ in a real-life cohort using a drug-resistant AVA assay. METHODS: Using a combination of VDZ/AVA complex precipitation and acid dissociation, a drug-resistant assay for AVA detection in the presence of high VDZ concentrations has been developed and analytically validated...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29129898/aggregation-behavior-of-disulfide-linked-gemini-surfactants-compared-to-that-of-double-tailed-surfactants
#20
Yukina Takano, Tsuyoshi Asakawa, Mayumi Inai, Akio Ohta, Hitoshi Asakawa
Disulfide linked gemini surfactant having a long spacer chain, [C10H21N(CH3)2(CH2)11SS(CH2)11N (CH3)2C10H21]2Br (2C1011SS), was prepared by the hydrolysis and oxidation process of thioester group for [C10H21N(CH3)2(CH2)11SCOCH3]Br. The critical vesicle concentrations of double tailed surfactants such as dialkyldimethylammonium bromide were observed by the conductivity and light scattering methods. The disulfide bonds of gemini surfactant, [C12H25N(CH3)2CH2CH2SSCH2CH2N(CH3)2C12H25]2Br (2C12SS), were rapidly cleaved by the addition of water-soluble dithiothreitol...
November 13, 2017: Journal of Oleo Science
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