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Tadashi Sugahara, Yuichiro Takamatsu, Avinash Bhadani, Masaaki Akamatsu, Kenichi Sakai, Masahiko Abe, Hideki Sakai
In this study, we synthesize a novel oleic acid-based gemini surfactant with carboxylate headgroups, and study the effect of stereochemistry (anti- vs. syn-) on self-aggregation properties in water. We investigate these properties using phase diagrams, static surface tension, and one-dimensional and two-dimensional nuclear magnetic resonance (NMR) measurements. We find that a phase transition from a hexagonal liquid crystal (H1) phase to a lamellar liquid crystal (Lα) phase occurs at a lower surfactant concentration in the syn form, when compared with the anti form...
March 16, 2018: Physical Chemistry Chemical Physics: PCCP
Anna Koziróg, Bogumił Brycki, Katarzyna Pielech-Przybylska
This study investigates the biological activity of two cationic gemini surfactants, hexamethylene-1,6-bis-( N , N -dimethyl- N -dodecylammonium bromide) C6 and pentamethylene-1,5-bis-( N , N -dimethyl- N -dodecyla,.mmonium bromide) C5, and their two neutral analogs, hexamethylene-1,6-bis-( N -methyl- N -dodecylamine) (A6) and pentamethylene-1,5-bis-( N -methyl- N -dodecylamine) (A5). Experiments were performed with Aspergillus brasiliensis , which is used in the standard tests for biocides. The minimal inhibitory concentration (MIC) values for conidia and mycelium were determined using the dilution method...
March 15, 2018: International Journal of Molecular Sciences
Min Yang, Zhonghua Dong, Xiaoyan Jiang, Zhongxi Zhao, Jianqiang Zhang, Xinke Cao, Daizhou Zhang
In this work, a rapid, simple, sensitive and specific LC-MS/MS method was developed and validated for the quantification of S-Allylmercaptocysteine (SAMC) in plasma. After a simple sample procedure by one step protein precipitation with acetontrile, the samples were separated on Gemini-NX C18 column (2.1 mm i.d. 150 mm, 3 μm, Phenomenex). The mobile phase was composed of water-acetonitrile (20:80, v/v) at an isocratic flow rate of 0.3 mL/min. The developed method was validated based on the International Conference on Harmonization (ICH) guidelines...
March 7, 2018: Journal of Chromatographic Science
Romain Madelaine, James H Notwell, Gemini Skariah, Caroline Halluin, Charles C Chen, Gill Bejerano, Philippe Mourrain
Thousands of human disease-associated single nucleotide polymorphisms (SNPs) lie in the non-coding genome, but only a handful have been demonstrated to affect gene expression and human biology. We computationally identified risk-associated SNPs in deeply conserved non-exonic elements (CNEs) potentially contributing to 45 human diseases. We further demonstrated that human CNE1/rs17421627 associated with retinal vasculature defects showed transcriptional activity in the zebrafish retina, while introducing the risk-associated allele completely abolished CNE1 enhancer activity...
March 6, 2018: Nucleic Acids Research
Apensu Dey, Victoria Sandre, Daniel Gerrard Marangoni, Soumen Ghosh
Ibuprofen (IBF), 2-(4-isobutylphenyl) propionic acid, is a surface active, common non-steroidal anti-inflammatory drug (NSAID); IBF possesses a high critical micelle concentration (cmc) when compared to conventional surfactants. The interactions of this common NSAID with an anionic surfactant, sodium octyl sulfosuccinate (AOT) were studied bytensiometric, fluorimetric, and calorimetric measurementsin order to investigate this system as a possible model drug delivery system for an NSAID like IBF, particularly in a high dose regime for IBF...
March 7, 2018: Journal of Physical Chemistry. B
Jing Sun, Chong Qiu, Yiping Diao, Wei Wei, Hongwei Jin, Yi Zheng, Jiancheng Wang, Lihe Zhang, Zhenjun Yang
Small interfering RNA (siRNA) has been continuously explored for clinical applications. However, neither nanocarriers nor conjugates have been able to remove the obstacles. In this study, we employed a combined nanochemistry strategy to optimize its delivery dilemma, where different interactions and assembly modes were cooperatively introduced into the forming process of siRNA/lipids nanoplexes. In the nanoplexes, the 3',3″-bis-peptide-siRNA conjugate (pp-siRNA) and gemini-like cationic lipids (CLDs) were employed as dual regulators to improve their bio-behavior...
March 2, 2018: Molecular Therapy. Nucleic Acids
Bappa Maiti, Mohini Kamra, Anjali A Karande, Santanu Bhattacharya
Herein, five new α-tocopheryl cationic gemini lipids with hydroxyethyl bearing headgroups (THnS, n = 4, 5, 6, 8, 12) have been synthesized for efficient plasmid DNA (pDNA) delivery into cancer cells. Among these gemini lipid formulations, the lipid with an octamethylene [-(CH2 )8 ] spacer (TH8S) showed the highest transfection efficiency (TE) that was comparable to that of the commercial standard lipofectamine 2000 (L2K) in terms of luciferase expression in HepG2 (liver hepatocellular carcinoma) cells. The addition of the helper lipid DOPE (1,2-dioleoyl phosphatidyl ethanolamine) with cationic lipids in mixed liposomes further enhanced the TE and the optimized molar ratio was 2 : 1 (DOPE : cationic lipid)...
March 2, 2018: Organic & Biomolecular Chemistry
Karolina Sakowska, Giorgio Alberti, Lorenzo Genesio, Alessandro Peressotti, Gemini Delle Vedove, Damiano Gianelle, Roberto Colombo, Mirco Rodeghiero, Cinzia Panigada, Radosław Juszczak, Marco Celesti, Micol Rossini, Matthew Haworth, Benjamin W Campbell, Jean-Philippe Mevy, Loris Vescovo, M Pilar Cendrero-Mateo, Uwe Rascher, Franco Miglietta
The photosynthetic, optical and morphological characteristics of a chlorophyll-deficient (Chl-deficient) "yellow" soybean mutant (MinnGold) were examined in comparison with two green varieties (MN0095 and Eiko). Despite the large difference in Chl content, similar leaf photosynthesis rates were maintained in the Chl-deficient mutant by offsetting the reduced absorption of red photons by a small increase in photochemical efficiency and lower non-photochemical quenching (NPQ). When grown in the field, at full canopy cover, the mutants reflected a significantly larger proportion of incoming shortwave radiation, but the total canopy light absorption was only slightly reduced, most likely due to a deeper penetration of light into the canopy space...
March 2, 2018: Plant, Cell & Environment
Ji-Yeon Lee, Jaechan Ahn, Sang In An, Jeong-Won Park
Objectives: The aim of this study is to compare the shear bond strengths of ceramic brackets bonded to zirconia surfaces using different zirconia primers and universal adhesive. Materials and Methods: Fifty zirconia blocks (15 × 15 × 10 mm, Zpex, Tosoh Corporation) were polished with 1,000 grit sand paper and air-abraded with 50 µm Al2 O3 for 10 seconds (40 psi). They were divided into 5 groups: control (CO), Metal/Zirconia primer (MZ, Ivoclar Vivadent), Z-PRIME Plus (ZP, Bisco), Zirconia Liner (ZL, Sun Medical), and Scotchbond Universal adhesive (SU, 3M ESPE)...
February 2018: Restorative Dentistry & Endodontics
Ruby Aslam, Mohammad Mobin, Jeenat Aslam, Hassane Lgaz
The inhibitory behaviour of non-ionic sugar based N,N'-didodecyl-N,N'-digluconamideethylenediamine gemini surfactant, designated as Glu(12)-2-Glu(12) on mild steel (MS) corrosion in 3.5% NaCl at 30-60 °C was explored using weight loss, PDP, EIS and SEM/EDAX/AFM techniques. The compound inhibited the corrosion of mild steel in 3.5% NaCl and the extent of inhibition was dependent on concentration and temperature. The inhibiting action of Glu(12)-2-Glu(12) is synergistically enhanced on addition of potassium iodide (KI) at all concentrations and temperatures...
February 27, 2018: Scientific Reports
Maria Mendes, Ana Miranda, Tânia Cova, Lídia Gonçalves, António Almeida, João Sousa, Maria L C do Vale, Eduardo F Marques, Alberto Pais, Carla Vitorino
Surface modification of ultra-small nanostructured lipid carriers (usNLC) via introduction of a positive charge is hypothesized to prompt site-specific drug delivery for glioblastoma multiforme (GBM) treatment. A more effective interaction with negatively charged lipid bilayers, including the blood-brain barrier (BBB), will facilitate the nanoparticle access to the brain. For this purpose, usNLC relying on a novel strategy in which two different liquid compounds are combined within the solid lipid matrix, yielded a particle size of 43...
February 24, 2018: European Journal of Pharmaceutical Sciences
Brian G Feagan, David Schwartz, Silvio Danese, David T Rubin, Trevor W Lissoos, Jing Xu, Karen Lasch
Background and Aims: Medical management of fistulising Crohn's disease (CD) is constrained by the limited number of available therapies. We evaluated the efficacy of vedolizumab, a gut-selective α4β7 integrin antagonist approved for treating moderately to severely active CD, in a subpopulation of patients with fistulising CD who participated in the GEMINI 2 trial (NCT00783692). Methods: Exploratory analyses of data from the GEMINI 2 trial were conducted in 461 responders to 6-week vedolizumab induction therapy who received maintenance placebo (VDZ/PBO, N=153) or vedolizumab (VDZ/VDZ, N=308)...
February 17, 2018: Journal of Crohn's & Colitis
Yashpal S Chhonker, Staci L Haney, Robert A Matthiesen, David F Wiemer, Sarah A Holstein, Daryl J Murry
An isomeric mixture of homogeranyl/homoneryl triazole bisphosphonates (VSW1198) has previously been shown to be a potent inhibitor of geranylgeranyl diphosphate (GGDP) synthase (GGDPS) and of therapeutic interest for the treatment of multiple myeloma. We have developed and validated a selective and sensitive liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantitation of both the E- and Z- isomers of VSW1198 in cell culture media, mouse plasma and tissues. VSW1198 and internal standard are extracted from the bio-matrices by solid-phase extraction, followed by derivatization using trimethylsilyldiazomethane...
February 6, 2018: Journal of Pharmaceutical and Biomedical Analysis
Tongtong Tian, Qi Kang, Tao Wang, Jianhong Xiao, Li Yu
A series of cationic gemini surfactants with diverse chemical structures, that is, imidazolium-based gemini surface active ionic liquids (gemini IM-SAILs) with different alkyl chain length or spacer length, viz. 1,s-bis(3-alkylimidazolium-1-yl) ethane bromide ([C n -s-C n im]Br 2 ; s = 2, n = 6, 8, 10, 12, 16; n = 12, s = 2, 4, 6, 10), and quaternary ammonium-based gemini surfactants (gemini QASaa) with different symmetries, viz. 1,2-bisalkylquaternary ammonium bromide (m-2-n; m = 12, 14, 16, n = 8, 10, 12, m + n = 24), were synthesized and utilized to decorate aqueous/liquid crystal interfaces (ALI)...
February 9, 2018: Journal of Colloid and Interface Science
Mattia Capulli, Marco Ponzetti, Antonio Maurizi, Sara Gemini-Piperni, Thorsten Berger, Tak Wah Mak, Anna Teti, Nadia Rucci
Lipocalin 2 (Lcn2) is an adipokine that carries out a variety of functions in diverse organs. We investigated the bone phenotype and the energy metabolism of Lcn2 globally deleted mice (Lcn2 -/- ) at different ages. Lcn2 -/- mice were largely osteopenic, exhibiting lower trabecular bone volume, lesser trabecular number and higher trabecular separation when compared to wild type (WT) mice. Lcn2 -/- mice showed a lower osteoblast number and surface over bone surface, and subsequently a significantly lower bone formation rate, while osteoclast variables were unremarkable...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Lukáš Hubčík, Dominika Galliková, Petra Pullmannová, Ľubica Lacinová, Zdena Sulová, Mária Hanulová, Sergio S Funari, Ferdinand Devínsky, Daniela Uhríková
DNA condensation, structure and transfection efficiency of complexes formed by gemini surfactants alkane-α,ω-diyl-bis(dodecyldimethylammonium bromide)s (CnGS12, n = 3, 6 and 12 is the number of alkane spacer carbons), dioleoylphosphatidylethanolamine (CnGS12/DOPE = 0.3 mol/mol) and DNA at low surface charge density were investigated through different techniques. Small angle X-ray diffraction showed a condensed lamellar phase with marked dependence of DNA-DNA distance on (+/-) charge ratio. High ionic strength of hydrating medium screens the interaction DNA - CnGS12/DOPE and complexed DNA represented maximally ~ 45-60% of total DNA in the solution as derived from fluorescence and UV-VIS spectroscopy...
January 2018: General Physiology and Biophysics
J M Martínez-Magadán, A R Cartas-Rosado, R Oviedo-Roa, R Cisneros-Dévora, M Pons-Jiménez, R Hernández-Altamirano, L S Zamudio-Rivera
Branched gemini zwitterionic liquids, which contain two zwitterionic moieties of linked quaternary-ammonium and carboxylate groups, are proposed as chemicals to be applied in the Enhanced Oil Recovery (EOR) from fractured carbonate reservoirs. The zwitterionic moieties are bridged between them through an alkyl chain containing 12 ether groups, and each zwitterionic moiety has attached a long alkyl tail including a CC double bond. A theoretical molecular mechanism over which EOR could rest, consisting on both the disaggregation of heavy oil and the reservoir-rock wettability alteration, was suggested...
January 31, 2018: Journal of Molecular Graphics & Modelling
Paulina Cegla, Arkadiusz Spychala, Andrzej Marszalek, Ewa Wierzchoslawska, Witold Cholewinski
The present study, discussed a rare case of a 50-year-old woman who was treated for malignant melanoma and underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) examination for evaluation of disease. 18F-FDG-PET/CT examination was performed from the top of the head down to the knee using a Gemini TF PET/CT scanner 60 min following intravenous injection of radiotracer with mean activity of 364±75 MBq. Previous performed laboratory test and clinical examination was irrelevant...
January 2018: Molecular and Clinical Oncology
Sriteja Mantha, Grayson L Jackson, Mahesh K Mahanthappa, Arun Yethiraj
The dynamics of confined water is of fundamental and long-standing interest. In technologically important forms of confinement, such as proton exchange membranes, electrostatic interactions with the confining matrix and counterions play significant roles on the properties of water. There has been recent interest on the dynamics of water confined to the lyotropic liquid crystalline (LLC) morphologies of Gemini dicarboxylate surfactants. These systems are exciting because the nature of confinement, e.g., size and curvature of channels and surface functionality is dictated by the chemistry of the self-assembling surfactant molecules...
February 4, 2018: Journal of Physical Chemistry. B
Lijie Zhai, Erik Ladomersky, Alicia Lenzen, Brenda Nguyen, Ricky Patel, Kristen L Lauing, Meijing Wu, Derek A Wainwright
Indoleamine 2, 3-dioxygenase 1 (IDO1) is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan (Trp) into downstream catabolites known as kynurenines. Coincidently, numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer. Preclinical studies have further introduced an interesting paradox: while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden, approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival...
January 29, 2018: Cellular & Molecular Immunology
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