keyword
https://read.qxmd.com/read/38519181/prebiotics-modulate-the-microbiota-gut-brain-axis-and-ameliorate-anxiety-and-depression-like-behavior-in-hfd-fed-mice
#1
JOURNAL ARTICLE
Igor Henrique Rodrigues de Paiva, Laís Macedo Maciel, Rodrigo Soares da Silva, Ingrid Prata Mendonça, José Roberto Botelho de Souza, Christina Alves Peixoto
Previous research has demonstrated that Prebiotics can influence the composition of the gut microbiota, consequently impacting mood regulation. This study aimed to assess the effects of Prebiotics, specifically Fructooligosaccharides (FOS) and Galactooligosaccharides (GOS) on neuroinflammation, depression, and anxiety-like behavior in a mouse model fed a high-fat diet (HFD). Initially, mice were divided into two groups: a control group on a standard diet (n = 15) and a group on an HFD for 18 weeks (n = 45)...
April 2024: Food Research International
https://read.qxmd.com/read/38517222/new-pharmacotherapies-to-tackle-the-unmet-needs-in-bipolar-disorder-a-focus-on-acute-suicidality
#2
REVIEW
Georgios D Kotzalidis, Federica Fiaschè, Alessandro Alcibiade, Laura Monti, Federica Di Segni, Marianna Mazza, Gabriele Sani
INTRODUCTION: Suicidal behavior is relatively frequent in patients with bipolar disorder (BD) and constitutes their most frequent cause of death. Suicide rates remain high in patients with BD despite adherence to guidelines recommending lithium as first line, and/or antidepressants, antipsychotics, psychotherapy, psychosocial interventions, and electroconvulsive therapy. Hence the need to identify more effective and rapid anti-suicide interventions. AREAS COVERED: To tackle the unmet needs of pharmacotherapy, we investigated the PubMed database on 24-25 January 2024 using strategies like ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (lithium[ti] OR clozapine[ti]), which obtained 3 results, and ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (ketamine[ti] OR esketamine[ti] OR NMDA[ti] OR glutamat*[ti]), which yielded 14 results...
March 22, 2024: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/38492880/etomidate-enhances-cerebellar-cf-pc-synaptic-plasticity-through-cb1-receptor-pka-cascade-in-vitro-in-mice
#3
JOURNAL ARTICLE
Guang-Gao Li, Ying-Han Xu, Ming-Ze Sun, Yan-Hua Bing, Wen-Zhe Jin, De-Lai Qiu
Etomidate (ET) is a widely used intravenous imidazole general anesthetic, which depresses the cerebellar neuronal activity by modulating various receptors activity and synaptic transmission. In this study, we investigated the effects of ET on the cerebellar climbing fiber-Purkinje cells (CF-PC) plasticity in vitro in mice using whole-cell recording technique and pharmacological methods. Our results demonstrated that CF tetanic stimulation produced a mGluR1-dependent long-term depression (LTD) of CF-PC excitatory postsynaptic currents (EPSCs), which was enhanced by bath application of ET (10 µM)...
March 15, 2024: Neuroscience Letters
https://read.qxmd.com/read/38492875/isradipine-an-l-type-calcium-channel-blocker-attenuates-cocaine-effects-in-mice-by-reducing-central-glutamate-release
#4
JOURNAL ARTICLE
Anna Luiza Diniz Lima, Emanuele Guimarães Silva, Pablo Leal Cardozo, Maria Carolina Machado da Silva, Suélyn Koerich, Fabíola Mara Ribeiro, Fabrício A Moreira, Luciene Bruno Vieira
Substance abuse disorder is a chronic condition for which pharmacological treatment options remain limited. L-type calcium channels (LTCC) have been implicated in drug-related plasticity and behavior. Specifically, dopaminergic neurons in the mesocorticolimbic pathway express Cav 1.2 and Cav 1.3 channels, which may regulate dopaminergic activity associated with reward behavior. Therefore, this study aimed to investigate the hypothesis that pre-administration of the LTCC blocker, isradipine can mitigate the effects of cocaine by modulating central glutamatergic transmission...
March 14, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38479542/sinisan-exerts-antidepressant-effects-by-modulating-serotonergic-gabaergic-neuron-activity-in-the-dorsal-raphe-nucleus-region-through-nmda-receptor-in-the-adolescent-depression-mouse-model
#5
JOURNAL ARTICLE
Kerun Cao, Jialong Zhong, Shanshan Wang, Yafei Shi, Shasha Bai, Jinlan Zhao, Lei Yang, Qi Liang, Di Deng, Rong Zhang
No abstract text is available yet for this article.
March 11, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38460902/glycine-transporter-1-inhibition-by-nfps-promotes-neuroprotection-against-striatal-damage-models
#6
JOURNAL ARTICLE
Raul Izidoro Ribeiro, Gustavo Almeida Carvalho, Raphaela Almeida Chiareli, Isabel Vieira de Assis Lima, Paula Maria Quaglio Bellozi, Onésia Cristina Oliveira-Lima, Ágatha Oliveira Giacomelli, Alexander Birbrair, Renato Santiago Gomez, Antônio Carlos Pinheiro de Oliveira, Henning Ulrich, Mauro Cunha Xavier Pinto
The striatum, an essential component of the brain's motor and reward systems, plays a pivotal role in a wide array of cognitive processes. Its dysfunction is a hallmark of neurodegenerative diseases like Parkinson's disease (PD) and Huntington's disease (HD), leading to profound motor and cognitive deficits. These conditions are often related to excitotoxicity, primarily due to overactivation of NMDA receptors (NMDAR). In the synaptic cleft, glycine transporter type 1 (GlyT1) controls the glycine levels, a NMDAR co-agonist, which modulates NMDAR function...
March 7, 2024: Neuroscience Letters
https://read.qxmd.com/read/38417539/bdnf-in-neuropathic-pain-the-culprit-that-cannot-be-apprehended
#7
REVIEW
Peter A Smith
In males but not in females, brain derived neurotrophic factor (BDNF) plays an obligatory role in the onset and maintenance of neuropathic pain. Afferent terminals of injured peripheral nerves release colony stimulating factor (CSF-1) and other mediators into the dorsal horn. These transform the phenotype of dorsal horn microglia such that they express P2X4 purinoceptors. Activation of these receptors by neuron-derived ATP promotes BDNF release. This microglial-derived BDNF increases synaptic activation of excitatory dorsal horn neurons and decreases that of inhibitory neurons...
February 26, 2024: Neuroscience
https://read.qxmd.com/read/38416255/enhanced-nmda-receptor-pathway-and-glutamate-transmission-in-the-hippocampal-dentate-gyrus-mediate-the-spatial-learning-and-memory-impairment-of-obese-rats
#8
JOURNAL ARTICLE
Dingding Lv, Bin Xiao, Huaying Liu, Linping Wang, Yingshun Li, Yin Hua Zhang, Qinghua Jin
Obesity has been linked with the impairment of spatial memory and synaptic plasticity but the molecular mechanisms remained unidentified. Since glutamatergic transmission and NMDA receptor neural pathways in hippocampal dentate gyrus (DG) are essential in the learning and memory, we aimed to investigate glutamate (Glu) and NMDA receptor signaling of DG in spatial learning and memory in diet-induced obesity (DIO) rats. Spatial learning and memory were assessed via Morris water maze (MWM) test on control (Ctr) and DIO rats...
February 28, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38415801/n-methyl-d-aspartate-receptors-structure-function-and-role-in-organophosphorus-compound-poisoning
#9
REVIEW
Dora Kolić, Zrinka Kovarik
Acute organophosphorus compound (OP) poisoning induces symptoms of the cholinergic crises with the occurrence of severe epileptic seizures. Seizures are induced by hyperstimulation of the cholinergic system, but are enhanced by hyperactivation of the glutamatergic system. Overstimulation of muscarinic cholinergic receptors by the elevated acetylcholine causes glutamatergic hyperexcitation and an increased influx of Ca2+ into neurons through a type of ionotropic glutamate receptors, N-methyl-d-aspartate (NMDA) receptors (NMDAR)...
February 28, 2024: BioFactors
https://read.qxmd.com/read/38411499/the-anterior-retrosplenial-cortex-is-required-for-short-term-object-in-place-recognition-memory-retrieval-role-of-ionotropic-glutamate-receptors-in-male-and-female-long-evans-rats
#10
JOURNAL ARTICLE
Dan L McElroy, Hassaan Sabir, Aiden E Glass, Quentin Greba, John G Howland
The anterior retrosplenial cortex (aRSC) integrates multimodal sensory information into cohesive associative recognition memories. Little is known about how information is integrated during different learning phases (i.e., encoding and retrieval). Additionally, sex differences are observed in performance of some visuospatial memory tasks; however, inconsistent findings warrant more research. We conducted three experiments using the 1-h delay object-in-place (1-h OiP) test to assess recognition memory retrieval in male and female Long-Evans rats...
February 27, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38408411/nmda-receptor-mediated-ca-2-signaling-impact-on-cell-cycle-regulation-and-the-development-of-neurodegenerative-diseases-and-cancer
#11
REVIEW
Ana L González-Cota, Daniel Martínez-Flores, Margarita Jacaranda Rosendo-Pineda, Luis Vaca
NMDA receptors are Ca2+ -permeable ligand-gated ion channels that mediate fast excitatory transmission in the central nervous system. NMDA receptors regulate the proliferation and differentiation of neural progenitor cells and also play critical roles in neural plasticity, memory, and learning. In addition to their physiological role, NMDA receptors are also involved in glutamate-mediated excitotoxicity, which results from excessive glutamate stimulation, leading to Ca2+ overload, and ultimately to neuronal death...
February 14, 2024: Cell Calcium
https://read.qxmd.com/read/38406200/electric-field-effects-on-neuronal-input-output-relationship-by-regulating-nmda-spikes
#12
JOURNAL ARTICLE
Yaqin Fan, Xile Wei, Meili Lu, Jiang Wang, Guosheng Yi
UNLABELLED: Evidence shows that the dendritic polarization induced by weak electrical field (EF) can affect the neuronal input-output function via modulating dendritic integration of AMPA synapses, indicating that the supralinear dendritic integration of NMDA synapses can also be influenced by dendritic polarization. However, it remains unknown how dendritic polarization affects NMDA-type dendritic integration, and then contributes to neuronal input-output relationship. Here, we used a computational model of pyramidal neuron with inhomogeneous extracellular potentials to characterize the relationship among EF, dendritic integration, and somatic output...
February 2024: Cognitive Neurodynamics
https://read.qxmd.com/read/38405040/nmda-receptor-modulation-by-esculetin-investigating-behavioral-biochemical-and-neurochemical-effects-in-schizophrenic-mice-model
#13
JOURNAL ARTICLE
Iqra Khalid, Uzma Saleem, Bashir Ahmad, Mohammed F Hawwal, Ramzi A Mothana
Schizophrenia, a global mental health disorder affecting approximately 1 % of the population, is characterized by neurotransmitter dysregulation, particularly dopamine, serotonin, and glutamate. Current antipsychotic therapies, despite their efficacy, are accompanied by adverse effects, which has motivated researchers to investigate more secure substitutes. This study examines the potential antipsychotic effects of esculetin, a natural coumarin derivative recognized for its wide-ranging pharmacological activities (anti-inflammatory, antioxidant, anti-pathogenic, anticancer, and neuroprotective), in animal model of schizophrenia induced by ketamine...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38402188/induced-neural-phase-precession-through-exogenous-electric-fields
#14
JOURNAL ARTICLE
Miles Wischnewski, Harry Tran, Zhihe Zhao, Sina Shirinpour, Zachary J Haigh, Jonna Rotteveel, Nipun D Perera, Ivan Alekseichuk, Jan Zimmermann, Alexander Opitz
The gradual shifting of preferred neural spiking relative to local field potentials (LFPs), known as phase precession, plays a prominent role in neural coding. Correlations between the phase precession and behavior have been observed throughout various brain regions. As such, phase precession is suggested to be a global neural mechanism that promotes local neuroplasticity. However, causal evidence and neuroplastic mechanisms of phase precession are lacking so far. Here we show a causal link between LFP dynamics and phase precession...
February 24, 2024: Nature Communications
https://read.qxmd.com/read/38401792/the-nmda-receptor-modulator-zelquistinel-durably-relieves-behavioral-deficits-in-three-mouse-models-of-autism-spectrum-disorder
#15
JOURNAL ARTICLE
Mathieu Fonteneau, Agathe Brugoux, Déborah Jaccaz, John E Donello, Pradeep Banerjee, Julie Le Merrer, Jérôme Aj Becker
Autism spectrum disorders (ASD) are complex neurodevelopmental disorders characterized by deficient social communication and interaction together with restricted, stereotyped behaviors. Currently approved treatments relieve comorbidities rather than core symptoms. Since excitation/inhibition balance and synaptic plasticity are disrupted in ASD, molecules targeting excitatory synaptic transmission appear as highly promising candidates to treat this pathology. Among glutamatergic receptors, the NMDA receptor has received particular attention through the last decade to develop novel allosteric modulators...
February 22, 2024: Neuropharmacology
https://read.qxmd.com/read/38399371/functional-analysis-of-trpa1-trpm3-and-trpv1-channels-in-human-dermal-arteries-and-their-role-in-vascular-modulation
#16
JOURNAL ARTICLE
Eduardo Rivera-Mancilla, Linda Al-Hassany, Heleen Marynissen, Dorien Bamps, Ingrid M Garrelds, Jérôme Cornette, A H Jan Danser, Carlos M Villalón, Jan N de Hoon, Antoinette MaassenVanDenBrink
Transient receptor potential (TRP) channels are pivotal in modulating vascular functions. In fact, topical application of cinnamaldehyde or capsaicin (TRPA1 and TRPV1 channel agonists, respectively) induces "local" changes in blood flow by releasing vasodilator neuropeptides. We investigated TRP channels' contributions and the pharmacological mechanisms driving vasodilation in human isolated dermal arteries. Ex vivo studies assessed the vascular function of artery segments and analyzed the effects of different compounds...
January 25, 2024: Pharmaceuticals
https://read.qxmd.com/read/38380827/maturation-of-glutamatergic-transmission-onto-dorsal-raphe-serotonergic-neurons
#17
JOURNAL ARTICLE
Alexandre Kisner, Abigail M Polter
Serotonergic neurons in the dorsal raphe nucleus (DRN) play important roles early in postnatal development in the maturation and modulation of higher order emotional, sensory, and cognitive circuitry. This unique position makes these cells a substrate by which early experience can be wired into brain. In this study, we have investigated the maturation of synapses onto dorsal raphe serotonergic neurons in typically developing male and female mice using whole-cell patch-clamp recordings in ex vivo brain slices...
February 21, 2024: Journal of Neurophysiology
https://read.qxmd.com/read/38378276/brief-exposure-to-enriched-environment-rapidly-shapes-the-glutamate-synapses-in-the-rat-brain-a-metaplastic-fingerprint
#18
JOURNAL ARTICLE
Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamulera
Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due to its configurational complexity, the underlying mechanisms are not yet fully elucidated. Recent evidence suggests that EE, acting as a metaplastic agent, may affect glutamatergic mechanisms underlying appetitive memory and, in turn, modulate reward-seeking behaviours: here, we have investigated such a possibility following a brief EE exposure. Adult male Sprague-Dawley rats were exposed to EE for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of EE in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus (Hipp) brain areas, which are critical for reward and memory...
February 20, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38374232/clemastine-and-metformin-extend-the-window-of-nmda-receptor-surface-expression-in-ageing-oligodendrocyte-precursor-cells
#19
JOURNAL ARTICLE
Yasmine Kamen, Kimberley Anne Evans, Sergey Sitnikov, Sonia Olivia Spitzer, Omar de Faria, Mert Yucel, Ragnhildur Thóra Káradóttir
In the central nervous system, oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life, allowing for ongoing myelination and myelin repair. With age, differentiation efficacy decreases and myelin repair fails; therefore, recent therapeutic efforts have focused on enhancing differentiation. Many cues are thought to regulate OPC differentiation, including neuronal activity, which OPCs can sense and respond to via their voltage-gated ion channels and glutamate receptors...
February 19, 2024: Scientific Reports
https://read.qxmd.com/read/38370786/conformational-basis-of-subtype-specific-allosteric-control-of-nmda-receptor-gating
#20
Julia Bleier, Philipe Ribeiro Furtado de Mendonca, Chris Habrian, Cherise Stanley, Vojtech Vyklicky, Ehud Y Isacoff
N-methyl-D-aspartate receptors are ionotropic glutamate receptors that are integral to synaptic transmission and plasticity. Variable GluN2 subunits in diheterotetrameric receptors with identical GluN1 subunits set very different functional properties, which support their individual physiological roles in the nervous system. To understand the conformational basis of this diversity, we assessed the conformation of the common GluN1 subunit in receptors with different GluN2 subunits using single-molecule fluorescence resonance energy transfer (smFRET)...
February 11, 2024: bioRxiv
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