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Newborn hearing

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https://www.readbyqxmd.com/read/29784513/racial-and-ethnic-differences-in-the-prevalence-of-congenital-cytomegalovirus-infection
#1
Karen B Fowler, Shannon A Ross, Masako Shimamura, Amina Ahmed, April L Palmer, Marian G Michaels, David I Bernstein, Pablo J Sánchez, Kristina N Feja, Audra Stewart, Suresh Boppana
OBJECTIVE: To evaluate the impact of race and ethnicity upon the prevalence and clinical spectrum of congenital cytomegalovirus infection (cCMV). STUDY DESIGN: From 2007 to 2012, 100 332 infants from 7 medical centers were screened for cCMV while in the hospital. Ethnicity and race were collected and cCMV prevalence rates were calculated. RESULTS: The overall prevalence of cCMV in the cohort was 4.5 per 1000 live births (95% CI, 4.1-4.9)...
May 18, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29781705/early-hearing-detection-and-intervention-reflections-from-the-south-african-context
#2
Amisha Kanji
For researchers and clinicians in developing contexts like South Africa, the establishment of universal newborn hearing screening (UNHS) programmes is something which we have strived to achieve. However, we need to ask the question as to whether we have attempted to view our ultimate goal of achieving mandated UNHS programmes from the perspective of the South African healthcare system as a whole. The current manuscript is aimed at providing an overview of audiological services within a broader context, with reflections from a South African perspective, and a suggestion to consider alternatives to UNHS, particularly in the South African public health care sector...
April 19, 2018: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/29780965/cochlear-implantation-in-infants-below-12-months-of-age
#3
Richard T Miyamoto, Bethany Colson, Shirley Henning, David Pisoni
Objectives: To provide safety and efficacy data on infants implanted below 12 months of age. Methods: With the wide application of newborn hearing screening programs, infants with deafness are being identified at birth. When a hearing aid trial fails, cochlear implantation is the only option to restore hearing. Mounting evidence suggests that age at implantation is a strong predictor of language outcomes. Using the minimally invasive surgical technique we have employed for nearly two decades, a limited clinical trial was initiated in the year 2000 because this age limitation fell outside of FDA guidelines...
December 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29769344/efficient-delivery-of-hcmv-t-cell-antigens-by-attenuated-sendai-virus-vectors
#4
Richard Kiener, Markus Fleischmann, Marian Alexander Wiegand, Niels A W Lemmermann, Christiane Schwegler, Christine Kaufmann, Angelique Renzaho, Simone Thomas, Eva Felder, Hans Helmut Niller, Benedikt Asbach, Ralf Wagner
Human Cytomegalovirus (HCMV) represents a major cause of clinical complications during pregnancy as well as immunosuppression and the licensing of a protective HCMV vaccine remains an unmet global need. Herein, we designed and validated novel Sendai virus (SeV) vectors delivering T cell immunogens IE-1 and pp65. To enhance vector safety, we used a replication-deficient strain (rdSeV) that infects target cells in a non-productive manner while retaining viral gene expression. In this study, we explored the impact that transduction with rdSeV has on human dendritic cells (DCs) by comparing it to the parental, replication-competent Sendai virus strain (rcSeV) as well as the poxvirus strain Modified Vaccinia Ankara (MVA)...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29764722/middle-ear-disease-in-children-with-cleft-palate
#5
REVIEW
Tulasi Kota Karanth, Kenneth R Whittemore
OBJECTIVE: The objective of this review is to summarize all aspects of middle ear diseases in children with cleft palate (CP). METHODS: PubMed, Scopus, The Cumulative Index to Nursing and Allied Health Literature (CINAHL) and The Cochrane Library were searched for English-language randomized control trials (RCTs), meta-analyses, systematic reviews and observational studies published through 31st July 2017. RESULTS: Epidemiology and pathogenesis of middle ear diseases in children with cleft palate have been discussed in this review...
May 12, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29761033/diagnosis-and-treatment-of-congenital-sensorineural-hearing-loss
#6
Divya A Chari, Dylan K Chan
Purpose of Review: The aim of this report is to review current literature regarding the work-up and management of congenital sensorineural hearing loss. Recent Findings: Diagnostic evaluation of a newborn with sensorineural hearing loss begins with a complete audiologic evaluation and comprehensive history and physical exam. This review presents a diagnostic algorithm for the work-up of congenital hearing loss, focusing on the three following modalities: cytomegalovirus testing, genetic evaluation, and imaging...
December 2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/29753496/an-evidence-based-protocol-for-managing-neonatal-middle-ear-effusions-in-babies-who-fail-newborn-hearing-screening
#7
Brittany C Weber, Scott M Whitlock, Kaidi He, Blake S Kimbrell, Craig S Derkay
OBJECTIVES: To evaluate the prevalence of middle ear disease in infants referred for failed newborn hearing screening (NBHS) and to review patient outcomes after intervention in order to propose an evidence-based protocol for management of newborns with otitis media with effusion (OME) who fail NBHS. METHODS: 85 infants with suspected middle ear pathology were retrospectively reviewed after referral for failed NBHS. All subjects underwent a diagnostic microscopic exam with myringotomy with or without placement of a ventilation tube in the presence of a middle ear effusion and had intra-operative auditory brainstem response (ABR) testing or testing at a later date...
April 12, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29748705/hearing-loss-in-phace-syndrome-clinical-and-radiologic-findings
#8
Mark D Mamlouk, Bree Zimmerman, Erin F Mathes, Kristina W Rosbe
PURPOSE: To characterize the types of hearing loss, auditory-related imaging findings, and hemangioma characteristics in patients with Posterior fossa malformations, Hemangiomas, Arterial anomalies, Cardiac defects, and abnormalities of the Eye (PHACE) syndrome. METHODS: Retrospective medical records, audiologic data, and imaging review of all patients presenting to a tertiary care children's hospital with a proven diagnosis of PHACE syndrome from 2005 to 2016. RESULTS: Twelve patients were identified with hearing and imaging data...
May 10, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29728190/factors-predicting-health-practitioners-awareness-of-unhs-program-in-malaysian-non-public-hospitals
#9
Abdussalaam Iyanda Ismail, Abdul Halim Abdul Majid, Mohd Normani Zakaria, Nor Azimah Chew Abdullah, Sulaiman Hamzah, Siti Zamratol-Mai Sarah Mukari
OBJECTIVE: The current study aims to examine the effects of human resource (measured with the perception of health workers' perception towards UNHS), screening equipment, program layout and screening techniques on healthcare practitioners' awareness (measured with knowledge) of universal newborn hearing screening (UNHS) in Malaysian non-public hospitals. METHODS: Via cross sectional approach, the current study collected data using a validated questionnaire to obtain information on the awareness of UNHS program among the health practitioners and to test the formulated hypotheses...
June 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29720579/congenital-esophageal-atresia-and-microtia-in-a-newborn-secondary-to-mycophenolate-mofetil-exposure-during-pregnancy-a-case-report-and-review-of-the-literature
#10
Musaed Mohammed Alsebayel, Faisal Abdulrahman Abaalkhail, Faisal Mohammed Alsebayel, Dema A Alissa, Ahmed Hamdan Al-Jedai, Hussien Elsiesy
BACKGROUND Mycophenolate mofetil (MMF) is one of the most commonly prescribed drugs to prevent organ transplant rejection in combination with calcineurin inhibitors and steroids. It has a different toxicity profile than tacrolimus and cyclosporine.  Gastrointestinal tract disturbances are the most common adverse effects. The use of MMF in pregnant women, however, holds great risk of miscarriage and fetal development defects such as external ear malformation, ocular anomalies, cleft lip and palate, and abnormality of distal limbs, heart, esophagus, and kidneys...
May 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29708492/cochlear-microphonic-and-summating-potential-responses-from-click-evoked-auditory-brain-stem-responses-in-high-risk-and-normal-infants
#11
Lisa L Hunter, Chelsea M Blankenship, Rebekah G Gunter, Douglas H Keefe, M Patrick Feeney, David K Brown, Kelly Baroch
BACKGROUND: Examination of cochlear and neural potentials is necessary to assess sensory and neural status in infants, especially those cared for in neonatal intensive care units (NICU) who have high rates of hyperbilirubinemia and thus are at risk for auditory neuropathy (AN). PURPOSE: The purpose of this study was to determine whether recording parameters commonly used in click-evoked auditory brain stem response (ABR) are useful for recording cochlear microphonic (CM) and Wave I in infants at risk for AN...
May 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29707576/establishment-of-a-gene-detection-system-for-hotspot-mutations-of-hearing-loss
#12
Chao Wang, Shengzhou Wang, Hongyan Chen, Daru Lu
Hearing loss is an etiologically heterogeneous trait with a high incidence in China. Though conventional newborn hearing screening program has been widely adopted, gene detection can significantly improve the means of early discovering genetic risk factors. Thus, simple and efficient methods with higher sensitivity and lower cost for detecting hotspot mutations of hearing loss are urgently requested. Here we established a mutation detection system based on multiple fluorescent probe technique, which can detect and genotype nine hotspot mutations of four prominent hearing loss-related genes in two reactions on a four-channel real-time PCR instrument, including GJB2 (rs750188782, rs80338943, rs1110333204, and rs80338939), GJB3 (rs74315319), SLC26A4 (rs111033313 and rs121908362), and mtDNA 12S rRNA (rs267606617 and rs267606619)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29705727/does-screening-for-congenital-cytomegalovirus-at-birth-improve-longer-term-hearing-outcomes
#13
REVIEW
Cathie Hilditch, Bianca Liersch, Nicola Spurrier, Emily J Callander, Celia Cooper, Amy K Keir
Currently, the diagnosis of congenital cytomegalovirus (cCMV) infection in most highly resourced countries is based on clinical suspicion alone. This means only a small proportion of cCMV infections are diagnosed. Identification, through either universal or targeted screening of asymptomatic newborns with cCMV, who would previously have gone undiagnosed, would allow for potential early treatment with antiviral therapy, ongoing audiological surveillance and early intervention if sensorineural hearing loss (SNHL) is identified...
April 28, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29699019/-effects-of-ethylbenzene-on-cell-injury-and-mitochondrial-membrane-potential-of-cpcs
#14
L Sun, M Zhang, P Xu, L Fan, B Cui, Q Zeng, Q Gu
Objective: To investigate the effects of ethylbenzene on growth morphology、proliferation ability and mitochondrial membrane potential (MMP) of cochlear progenitor cells (CPCs) , and to lay a foundation for the mechanism of hearing loss induced by ethylbenzene. Methods: We can use the fluorescence microscopy to identify the original CPCs isolated from the newborn rats, and followed by the addition of different concentrations of ethylbenzene (0, 15, 30, 45 μmol/L) for 24 hours. The morphological changes of cell injury were observed by inverted optical microscope...
February 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29697646/-the-hearing-function-in-the-premature-children-following-their-treatment-with-the-use-of-ototoxic-antibiotics
#15
I N D'yakonova, I V Rakhmanova, Yu S Ishanova, D S Burmistrova
The objective of the present study was the evaluation of the state of the auditory function in the premature children during the first year of life who underwent the neonatal treatment with various ototoxic antibiotics. A total of 232 newborn infants were available for the examination by the methods designed for recording distortion product optoacoustic emission (DPOAE) and short-latency auditory evoked potentials (SAEPs). The 'Statgraphics Centurion XV' program was used for the statistical treatment of the data obtained in the study...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29689750/universal-newborn-hearing-screening-using-a-teoae-and-a-abr-the-experience-of-a-large-public-hospital
#16
F Cianfrone, F Mammarella, M Ralli, V Evetovic, C M Pianura, G Bellocchi
BACKGROUND: Universal newborn hearing screening (UNHS) aims to identify hearing loss in the early postnatal period; prompt detection of bilateral or unilateral hearing loss is mandatory for timely intervention. METHODS: This retrospective study reports the results of the first two years of a UNHS program on 4,719 newborns in a large public Italian hospital. Screening was divided into two levels: automated transient otoacoustic emissions were used for first level; automated auditory brainstem response for second level...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29681450/concurrent-hearing-genetic-and-cytomegalovirus-screening-in-newborns-taiwan
#17
Chun-Yi Lu, Po-Nien Tsao, Ying-Ying Ke, Yi-Hsin Lin, Yin-Hung Lin, Chia-Cheng Hung, Yi-Ning Su, Wei-Chung Hsu, Wu-Shiun Hsieh, Li-Min Huang, Chen-Chi Wu, Chuan-Jen Hsu
OBJECTIVE: To evaluate the feasibility and potential benefits of incorporating genetic and cytomegalovirus (CMV) screenings into the current newborn hearing screening (NHS) programs. STUDY DESIGN: Newborns were recruited prospectively from a tertiary hospital and a maternity clinic between May 2016 and December 2016 and were subjected to hearing screening, CMV screening, and genetic screening for 4 common mutations in deafness genes (p.V37I and c.235delC of GJB2 gene, c...
April 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29668474/craniosynostosis-acrocephalosyndactyly-apert-syndrome-diagnosed-in-a-newborn
#18
Orhideja Stomnaroska, Dragan Danilovski, Sanja Ivanovska
We report a 10 days old newborn with brachycephaly, midfacial hypoplasia, syndactyly and broad distal phalanx of thumb and big toe. At the 20th gestational weeks an enlargement of the left cerebral ventricle and malformation of the fingers of the hands and toes were noticed on a regular ultrasound examination. The aforementioned malformations were observed at birth and at the age of 11 months. The large fontal was closed; the small one was palpable at the tip of the finger. Brachycephaly was evident with high full forehead, flat occiput, and irregular craniosynostosis especially at the coronal suture...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/29622487/passing-the-newborn-hearing-screen-does-not-always-exclude-infectious-congenital-acquired-hearing-loss
#19
E Sabroske, M D Svoboda, Y-T Ng
No abstract text is available yet for this article.
February 8, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29620237/a-novel-missense-mutation-in-the-actg1-gene-in-a-family-with-congenital-autosomal-dominant-deafness-a-case-report
#20
Cha Gon Lee, Jahyeon Jang, Hyun-Seok Jin
The ACTG1 gene encodes the cytoskeletal protein γ-actin, which functions in non‑muscle cells and is abundant in the auditory hair cells of the cochlea. Autosomal dominant missense mutations in ACTG1 are associated with DFNA20/26, a disorder that is typically characterized by post‑lingual progressive hearing loss. To date, 17 missense mutations in ACTG1 have been reported in 20 families with DFNA20/26. The present study described a small family with autosomal dominant nonsyndromic hearing loss. A novel heterozygous missense mutation, c...
March 29, 2018: Molecular Medicine Reports
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