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https://www.readbyqxmd.com/read/28087323/severe-hemorrhagic-syndrome-after-lonomia-caterpillar-envenomation-in-the-western-brazilian-amazon-how-many-more-cases-are-there
#1
João Hugo A Santos, Sâmella S Oliveira, Eliane C Alves, Iran Mendonça-da-Silva, Jacqueline A G Sachett, Antonio Tavares, Luiz Carlos Ferreira, Hui Wen Fan, Marcus V G Lacerda, Wuelton M Monteiro
Contact with Lonomia caterpillars can cause a hemorrhagic syndrome. In Brazil, Lonomia obliqua and Lonomia achelous are known to cause this venom-induced disease. In the Brazilian Amazon, descriptions of this kind of envenomation are scarce. Herein, we report a severe hemorrhagic syndrome caused by Lonomia envenomation in the Amazonas state, Western Brazilian Amazon. The patient showed signs of hemorrhage lasting 8 days and required Lonomia antivenom administration, which resulted in resolution of hemorrhagic syndrome...
January 10, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28062377/proteomic-analysis-to-unravel-the-complex-venom-proteome-of-eastern-india-naja-naja-correlation-of-venom-composition-with-its-biochemical-and-pharmacological-properties
#2
Sumita Dutta, Abhishek Chanda, Bhargab Kalita, Taufikul Islam, Aparup Patra, Ashis K Mukherjee
: The complex venom proteome of the eastern India (EI) spectacled cobra (Naja naja) was analyzed using tandem mass spectrometry of cation-exchange venom fractions. About 75% of EI N. naja venom proteins were <18kDa and cationic at physiological pH of blood. SDS-PAGE (non-reduced) analysis indicated that in the native state venom proteins either interacted with each-other or self-aggregated resulting in the formation of higher molecular mass complexes. Proteomic analysis revealed that 43 enzymatic and non-enzymatic proteins in EI N...
January 4, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28062164/two-rare-case-reports-of-confirmed-ceylon-krait-bungarus-ceylonicus-envenoming-in-sri-lanka
#3
R M M K Namal Rathnayaka, S A M Kularatne, K D M Kumarasinghe, K Jeganadan, P E A Nishanthi Ranathunga
The Ceylon krait (Bungarus ceylonicus) is a deadly venomous elapid snake endemic to Sri Lanka. Its habitat is mainly in the wet zone of the island. Despite its frequent encounters in and near human dwellings, reports of envenoming are rare and limited to four in the literature. The first and last fatal reports envenoming by B. ceylonicus was in 1993. After over two decades, we report two confirmed cases of B. ceylonicus bites-one a dry bite and the other with signs and symptoms of moderate envenoming. The envenoming occurred at night while the victim was asleep, causing tightness in the chest and dyspnoea on waking up, followed by neuromuscular paralysis that did not cause respiratory failure and complete recovery was observed three days following the bite...
January 3, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28050465/lizard-bite-masquerading-as-scorpion-sting-envenomation
#4
Ramesh Neelannavar, Mallanagouda Patil, Shankargouda Patil, Bhavana Lakhkar, Vijaykumar Shegji
Lizard bite is very infrequent in children. Lizards tend to avoid confrontation. Bites are only inflicted when they are manipulated or when they are cornered and feel threatened. Lizard bites may be frightening but most do not cause serious health problems. The wall lizard or gecko, found in most homes, is not poisonous at all. It only checks insect population. A two-year-old boy was brought with history of lizard bite over right hand when he was trying to capture it. The child had experienced excessive sweating and irritability within two hours of bite...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28044352/delayed-allergic-dermatitis-presenting-as-a-keloid-like-reaction-caused-by-sting-from-an-indo-pacific-portuguese-man-o-war-physalia-utriculus
#5
B E K Guevara, J F Dayrit, V Haddad
Cnidarian envenomations are common occurrences in the tropics that can affect holidaymakers. The cutaneous reactions are classified as immediate or delayed types. Delayed allergic reactions are persistently recurring dermatitis, which can occur within 1-4 weeks from the initial sting, and may last for several months. Hypertrophic scar-like or keloid-like reactions are rare, and are believed to be a type IV hypersensitivity reaction to sequestered antigens from stinging filaments. We report an unusual case of delayed allergic dermatitis with keloid-like presentation caused by Physalia utriculus...
January 2, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28042812/snake-venom-metalloproteinases-and-their-peptide-inhibitors-from-myanmar-russell-s-viper-venom
#6
Khin Than Yee, Morgan Pitts, Pumipat Tongyoo, Ponlapat Rojnuckarin, Mark C Wilkinson
Russell's viper bites are potentially fatal from severe bleeding, renal failure and capillary leakage. Snake venom metalloproteinases (SVMPs) are attributed to these effects. In addition to specific antivenom therapy, endogenous inhibitors from snakes are of interest in studies of new treatment modalities for neutralization of the effect of toxins. Two major snake venom metalloproteinases (SVMPs): RVV-X and Daborhagin were purified from Myanmar Russell's viper venom using a new purification strategy. Using the Next Generation Sequencing (NGS) approach to explore the Myanmar RV venom gland transcriptome, mRNAs of novel tripeptide SVMP inhibitors (SVMPIs) were discovered...
December 30, 2016: Toxins
https://www.readbyqxmd.com/read/28017694/pitfalls-to-avoid-when-using-phage-display-for-snake-toxins
#7
Andreas Hougaard Laustsen, Line Præst Lauridsen, Bruno Lomonte, Mikael Rørdam Andersen, Brian Lohse
Antivenoms against bites and stings from snakes, spiders, and scorpions are associated with immunological side effects and high cost of production, since these therapies are still derived from the serum of hyper-immunized production animals. Biotechnological innovations within envenoming therapies are thus warranted, and phage display technology may be a promising avenue for bringing antivenoms into the modern era of biologics. Although phage display technology represents a robust and high-throughput approach for the discovery of antibody-based antitoxins, several pitfalls may present themselves when animal toxins are used as targets for phage display selection...
December 23, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28001231/arachnidism-scorpionism-and-ophidism-in-ouro-preto-municipality-minas-gerais-state-brazil
#8
Gabriela Fernanda Evangelista, Cristiano Schetini de Azevedo
INTRODUCTION: This retrospective study shows the profile of arachnidism, ophidism, and scorpionism in the Ouro Preto Municipality, Brazil, from January 2007 to December 2013. METHODS: The data were gathered from forms of the Epidemiological Surveillance Sector of the town's Health's Municipal Secretary. RESULTS: Of the 412 envenomations, 308 were caused by spiders, 78 by scorpions, and 26 by snakes. The highest number of incidents involved people aged 20-34 years...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28001213/an-overview-of-bothrops-erythromelas-venom
#9
Neriane Monteiro Nery, Karla Patrícia Luna, Carla Freire Celedônio Fernandes, Juliana Pavan Zuliani
This review discusses studies on the venom of Bothrops erythromelas published over the past 36 years. During this period, many contributions have been made to understand the venomous snake, its venom, and its experimental and clinical effects better. The following chronological overview is based on 29 articles that were published between 1979 and 2015, with emphasis on diverse areas. The complexity of this task demands an integration of multidisciplinary research tools to study toxinology. This science is in need of renewed conceptual and experimental platforms aimed at obtaining a profound understanding of the highly complex pathophysiology of snakebite envenoming and toxins isolated from snakes...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27989783/the-binding-effectiveness-of-anti-rdisintegrin-polyclonal-antibodies-against-disintegrins-and-pii-and-piii-metalloproteases-an-immunological-survey-of-type-a-b-and-a-b-venoms-from-mohave-rattlesnakes
#10
Esteban Cantú, Sahiti Mallela, Matthew Nyguen, Raúl Báez, Victoria Parra, Rachel Johnson, Kyle Wilson, Montamas Suntravat, Sara Lucena, Alexis Rodríguez-Acosta, Elda E Sánchez
Snake venoms are known to have different venom compositions and toxicity, but differences can also be found within populations of the same species contributing to the complexity of treatment of envenomated victims. One of the first well-documented intraspecies venom variations comes from the Mohave rattlesnake (Crotalus scutulatus scutulatus). Initially, three types of venoms were described; type A venom is the most toxic as a result of ~45% Mojave toxin in the venom composition, type B lacks the Mojave toxin but contains over 50% of snake venom metalloproteases (SVMP)...
October 27, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27984062/rbaltmip-a-recombinant-alpha-type-myotoxin-inhibitor-from-bothrops-alternatus-rhinocerophis-alternatus-snake-as-a-potential-candidate-to-complement-the-antivenom-therapy
#11
Norival A Santos-Filho, Tiago S Sousa, Johara Boldrini-França, Ludier K Santos-Silva, Danilo L Menaldo, Flávio Henrique-Silva, Adélia C O Cintra, Helen J Laure, Carla C N Mamede, Fábio de Oliveira, Thalita B Riul, Marcelo Dias-Baruffi, José C Rosa, Suely V Sampaio
Phospholipase A2 inhibitors (PLIs) are important targets in the search and development of new drugs. This study aimed at evaluating the potential of an alpha-type phospholipase A2 inhibitor from Bothrops alternatus (Rhinocerophis alternatus) snake in its recombinant form (rBaltMIP) to complement the conventional antivenom therapy. Biochemical experiments showed that rBaltMIP presented pI 5.8 and molecular masses of ∼21 kDa by SDS-PAGE and 19.57 kDa by MALDI/TOF MS. After tryptic peptides sequencing, the results were compared with other PLIs available in databases, showing 100% identity between rBaltMIP and its native inhibitor BaltMIP and from 92% to 96% identity with other inhibitors...
October 28, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27974231/fatal-self-envenomation-in-a-brown-tree-snake-boiga-irregularis-from-south-east-queensland
#12
Andrew Gordon Hill, Lewis McKillop
The case history and clinical signs of a fatal self-envenomation event by a brown tree snake, Boiga irregularis, in South-east Queensland, Australia, are presented. Clinical signs began 20 minutes post-envenomation with muscle twitching, ataxia, and heat seeking behavior which progressed to partial paralysis by 6 hours, generalised paralysis and respiratory arrest at 10 hours and cardiac arrest by 12 hours post-envenomation. Clinical signs are suggestive of potent neurotoxicity for B. irregularis to its own venom...
December 11, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27955986/role-of-angiotensin-ii-and-angiotensin-type-1-receptor-in-scorpion-venom-induced-cardiac-and-aortic-tissue-inflammation
#13
Amina Sifi, Sonia Adi-Bessalem, Fatima Laraba-Djebari
Scorpion stings are mainly associated with cardiovascular disturbances that may be the cause of death. In this study, the involvement of angiotensin II (Ang II) in cardiac and aortic inflammatory response was studied. Mice were injected with Androctonus australis hector (Aah) scorpion venom (0.5mg/kg, subcutaneously), in the presence or absence of an angiotensin converting enzyme (ACE) inhibitor, captopril (15mg/kg/day/1day intraperitoneally) or an angiotensin type-1 receptor (AT1R) antagonist, valsartan (15mg/kg/day/15days, orally)...
December 10, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27951506/corrigendum-to-rapid-and-selective-detection-of-experimental-snake-envenomation-use-of-gold-nanoparticle-based-lateral-flow-assay-toxicon-119-2016-299-306
#14
Balasaheb S Pawade, Nitin C Salvi, Innus K Shaikh, Arun B Waghmare, Nitin D Jadhav, Vishal B Wagh, Abhilasha S Pawade, Indrasen G Waykar, Mugdha Potnis-Lele
No abstract text is available yet for this article.
January 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27936776/unraveling-the-proteome-composition-and-immuno-profiling-of-western-india-russell-s-viper-venom-for-in-depth-understanding-of-its-pharmacological-properties-clinical-manifestations-and-effective-antivenom-treatment
#15
Bhargab Kalita, Aparup Patra, Ashis K Mukherjee
The proteome composition of western India (WI) Russell's viper venom (RVV) was correlated with pharmacological properties and pathological manifestations of RV envenomation. Proteins in the 5-19 and 100-110 kDa mass ranges were the most predominate (∼35.1%) and least abundant (∼3.4%) components, respectively, of WI RVV. Non-reduced SDS-PAGE indicated the occurrence of multiple subunits, non-covalent oligomers, self-aggregation, and/or interactions among the RVV proteins. A total of 55 proteins belonging to 13 distinct snake venom families were unambiguously identified by ESI-LC-MS/MS analysis...
December 12, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27930893/severe-snakebite-envenoming-in-intensive-care
#16
REVIEW
Jiří Valenta, Zdeněk Stach, Pavel Michálek
Snakebites by exotic venomous snakes can cause serious or even life-threatening envenoming. In Europe and North America most victims are breeders, with a few snakebites from wild native American rattlesnakes. The envenomed victims may present in organ and/or system failure with muscle paralysis, respiratory failure, circulatory instability, acute kidney injury, severe coagulation disorder, and local disability - compartment syndrome and necrosis. Best managed by close collaboration between clinical toxicology and intensive care, most severe envenomings are managed primarily by intensive care physicians...
2016: Prague Medical Report
https://www.readbyqxmd.com/read/27921219/nationwide-scorpion-exposures-reported-to-us-poison-control-centers-from-2005-to-2015
#17
A Min Kang, Daniel E Brooks
INTRODUCTION: Previous studies of scorpion envenomation in the United States (US) have focused on Arizona and the bark scorpion, Centruroides sculpturatus. Although many other scorpion species live in the US, information about envenomations in other states is lacking. METHODS: Nationwide scorpion exposures from 2005 to 2015 were analyzed using the National Poison Data System. RESULTS: Of the 185,402 total exposures, Arizona (68.2%), Texas (10...
December 5, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27912864/clinical-and-epidemiological-aspects-of-scorpionism-in-the-world-a-systematic-review
#18
REVIEW
Maria S V Santos, Cláudio G L Silva, Basílio Silva Neto, Cícero R P Grangeiro Júnior, Victor H G Lopes, Antônio G Teixeira Júnior, Deryk A Bezerra, João V C P Luna, Josué B Cordeiro, Jucier Gonçalves Júnior, Marcos A P Lima
OBJECTIVE: Scorpion stings are registered worldwide, but the incidence and the features of the envenomations vary depending on the region. The aim of this review was to summarize the epidemiological, clinical, diagnostic, and therapeutic data worldwide regarding humans stung by scorpions. METHODS: A systematic review of the literature was conducted through the online databases of the Virtual Health Library (VHL), which hosts Medline and the Latin American and Caribbean Center on Health Sciences Informational (LILACS) database...
December 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/27911900/clinical-and-pharmacological-investigation-of-myotoxicity-in-sri-lankan-russell-s-viper-daboia-russelii-envenoming
#19
Anjana Silva, Christopher Johnston, Sanjaya Kuruppu, Daniela Kneisz, Kalana Maduwage, Oded Kleifeld, A Ian Smith, Sisira Siribaddana, Nicholas A Buckley, Wayne C Hodgson, Geoffrey K Isbister
BACKGROUND: Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antivenom and the toxins responsible for myotoxicity. METHODOLOGY AND FINDINGS: Clinical features of myotoxicity were assessed in authenticated Russell's viper bite patients admitted to a Sri Lankan teaching hospital...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27904261/the-north-south-divide-in-snake-bite-envenomation-in-india
#20
REVIEW
Vivek Chauhan, Suman Thakur
Snake bite envenomations are common in rural areas and the incidence peaks during monsoons in India. Prominent venomous species have been traditionally labeled as the 'big four' that includes Cobra, Krait, Russel's viper and Saw scaled viper. Systematic attempts for identification and classification of prevalent snakes in various states of India are missing till now and there is no concrete data on this aspect. The published literature however shows that some species of snakes are more prevalent in a particular region than the other parts of India e...
October 2016: Journal of Emergencies, Trauma, and Shock
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