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JOURNAL ARTICLE
Fatih Çalış, Abdullah Talha Şimşek, Neslihan Gökmen İnan, Nur Topyalın, Baha E Adam, Çimen Elias, Muhammed Emin Aksu, Mohammed Aladdam, Güliz Gültekin, Muhammet Hüseyin Sorkun, Müjgan Tez, Naci Balak
BACKGROUND: Statistics show that over the past 2 decades, even in high-income countries, fewer and fewer students have listed neurosurgery as their top career option. Literature on medical students' pursuit of neurosurgical careers in middle- and low-income countries are scarce. The aim of this research, conducted in Turkey with a middle-income economy, was to contribute insights relevant to medical education and neurosurgery across the world. METHODS: A survey was conducted with a target sample of fourth-year (167 students), fifth-year (169 students), and sixth-year (140 students) medical students (476 in total) from the Medical School at Istanbul Medeniyet University in Turkey...
March 7, 2024: World Neurosurgery
#22
JOURNAL ARTICLE
Bahá El Kassaby, Francisco Castellanos, Matthew Gerring, Govindarajan Kunde-Ramamoorthy, Carol J Bult
The Mouse Variation Registry (MVAR) resource is a scalable registry of mouse single nucleotide variants and small indels and variant annotation. The resource accepts data in standard Variant Call Format (VCF) and assesses the uniqueness of the submitted variants via a canonicalization process. Novel variants are assigned a unique, persistent MVAR identifier; variants that are equivalent to an existing variant in the resource are associated with the existing identifier. Annotations for variant type, molecular consequence, impact, and genomic region in the context of specific transcripts and protein sequences are generated using Ensembl's Variant Effect Predictor (VEP) and Jannovar...
March 6, 2024: Journal of Molecular Biology
#23
JOURNAL ARTICLE
Salma Madihi, Chaimaa Laassili, Samia Boukaira, Warda Baha, Meriem Khyatti, Abdelmajid Zyad, Sanae Ben Mkaddem, Abdelouaheb Benani
Hepatitis B virus (HBV) infection is a global public health burden and affects approximatively 300 million people around the world. Since, HBV population is represented with genetic diversity, having different viral effects. Development of a new prognosis method play a key role on the efficiency of the different treatment. The HBx protein of HBV has a potential role in Hepatocellular Carcinoma (HCC), which makes it a valuable target for HCC prognosis. In this context, the first quantitative real-time PCR (qRT-PCR) assay in the Mediterranean area was developed and validated...
March 5, 2024: Journal of Virological Methods
#24
JOURNAL ARTICLE
Saleh Jamman M Alzahrani, Haya Abdulaziz K Alzahrani, Shahad Mohamad M Alghamdi, Atheer Nasser A Alzahrani
Introduction According to disability-adjusted life years (DALY), bronchial asthma (BA) is rated 28th among the top causes of disease burden globally and among the most significant reasons for years lived with disability. Internationally, 300 million people have asthma, and another 100 million individuals may develop it by 2025. In Al-Baha City, where environmental factors such as dust and pollen levels can exacerbate asthma symptoms, understanding and addressing the health-related quality of life of asthmatic patients is crucial...
February 2024: Curēus
#25
JOURNAL ARTICLE
Magdalena Ostrowska, Anitta Sisily Joseph, Maciej J Wróbel
We present a patient who suffered a temporal bone fracture (TBF) encompassing the bony labyrinth. Sensorineural hearing loss was confirmed with an unfavorable prognosis for recovery. Thirteen years later, there is regression of the hearing loss.
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
#26
JOURNAL ARTICLE
Baha Öndeş, Ulviye Kilimci, Murat Uygun, Deniz Aktaş Uygun
In this study, a simple, specific and sensitive immunosensor for CEA detection was prepared based on BN nanosheets. Lewis acid-base interaction was sufficient for the immobilization of anti-CEA used as an antibody on the electrode surface without an activation agent. This immunosensor could be used for CEA determination without the need to use any label or secondary antibody. With its epedance-based recognition mechanism, this immunosensor offered a low LOD value of 0.017 ng/mL and a wide measurement range of 0...
February 29, 2024: Bioelectrochemistry
#27
JOURNAL ARTICLE
Khalid Alawad A Mohammed, Elfatih Mirghani M Salih, Fahad Alamr, Mohammed Mousa M Alzahrani, Ahmed Surayyi A Khallufah, Khader Abdullah K Alghamdi, Yahya Fahad Y Alzahrani, Yasir Majhud S Alzahrani
Background Breastfeeding and complementary feeding are essential for baby health and nutrition. Concerning these feeding habits, there is a dearth of information on mother awareness and behaviors in Saudi Arabia. This study intends to evaluate maternal knowledge of breastfeeding and complementary feeding in Al Baha City, Saudi Arabia. Methodology This cross-sectional prospective study was conducted among mothers in Al Baha City, Saudi Arabia. Data were collected using a structured electronic questionnaire and analyzed using descriptive statistics and a chi-square test...
January 2024: Curēus
#28
Alhareth M Amro, Salah Deeb, Rama Rije, Nour Deeb, Yaman Y Qunaibi, Bajis Amr, Khaled Irzeqat, Baha Alhadad, Ahmad Emar
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that can affect the heart, lungs, and other organs. We describe the case of a 36-year-old female patient who first presented with non-specific symptoms before receiving a diagnosis of SLE, along with initial evidence of pleural effusion and cardiac tamponade. Heart tamponade, which is characterized by fluid accumulation in the pericardial space, is an unusual but serious side effect of SLE. Pleural effusion, or an accumulation of fluid in the pleural cavity, is a typical hallmark of SLE; however, it rarely manifests as the disease's initial symptom...
January 2024: Curēus
#29
Baha Sharaf, Zeina Othman, Hala Abu Faris, Malak Al-Bitar, Qasem Al-Zoubi, Dima Abu Laban, Hala Abu-Jaish, Hikmat Abdel-Razeq
Breast cancer is the most diagnosed cancer among women worldwide. Cyclin dependent kinase 4/6 inhibitors (ribociclib, palbociclib, and abemaciclib) modulate endocrine resistance and are widely used treatment for patients with advanced-stage hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. Reports of both venous and arterial thromboembolic events, as a complication of cyclin dependent kinase 4/6 inhibitors, are increasingly recognized, but none involved cerebral venous sinus...
2024: SAGE Open Medical Case Reports
#30
JOURNAL ARTICLE
Saleh Saad J Alzahrani, Nawaf Saleh A Alghamdi, Eyad Awad M Alzahrani, Fadi Ahmed M Alzahrani, Mohammed Ahmed A Alghamdi, Zaher Musleh S Hafiz, Amr A Fouad
BACKGROUND: Sickle cell disease (SCD) presents a major health challenge in Saudi Arabia due to its high prevalence. The important role of medical students as future healthcare leaders necessitates high awareness and knowledge about the disease. AIM: To assess SCD awareness among Al-Baha University medical students, and to evaluate its relation to gender and academic level. METHODS: A cross-sectional study was conducted, including 105 medical students from the first to sixth year at Al-Baha University...
January 2024: Curēus
#31
JOURNAL ARTICLE
Tajelsir Osman, Eman A Keshk, Meshari A Alghamdi, Faisal A Alzahrani, Abdulhakim Abdulrazaq M Alghamdi, Ayman G Alzahrani, Yahya Alzahrani, Mohammed Ahmed A Alghamdi, Adnan Saleh I Alghamdi, Abdulelah Abdulrazaq M Alghamdi
BACKGROUND: Gestational diabetes mellitus (GDM) is a condition characterized by glucose intolerance that develops during pregnancy. It is associated with adverse maternal and fetal outcomes and has long-term health implications for both the mother and the child. This study aimed to estimate the prevalence of adverse pregnancy outcomes in women with and without GDM in the Al-Baha region, Saudi Arabia. METHODS: A cross-sectional study was conducted in the Al-Baha region from April 2023 to November 2023...
January 2024: Curēus
#32
JOURNAL ARTICLE
Saba Beigh, Remas Adnan, Al-Johrah Abdulaziz, Samia Abdullah, Nada Nasser, Rana Ghazzay, Ruba Abdulaziz, Ethar Mohammed, Rabab Morsy Ahmad, Mohammed Ali Alshehri
BACKGROUND: The prevalence of dementia is escalating significantly, posing a substantial societal burden. Currently, there exists a dearth of comprehensive health data about dementia patients in Saudi Arabia, particularly within Al-Baha City. METHODS: A retrospective case-series study was undertaken to ascertain the prevalence of dementia within the populace of the Al-Baha region, Kingdom of Saudi Arabia. This investigation utilized hospital-based records encompassing individuals exhibiting symptoms or diagnosed with dementia and its related forms across the Al-Baha region...
January 2024: Curēus
#33
Marah Omer, Yavuz Yigit, Baha Hamdi Alkahlout, Eslam Hussein Mohamed, Sulafa Khalil, Aftab Mohammad Azad
Tizanidine withdrawal is a rare and complex phenomenon characterized by a surge in adrenergic activity upon abrupt discontinuation of the drug. We present a unique case of a 41-year-old male with multiple comorbidities who self-administered an exceptionally high daily dose of Tizanidine, leading to severe withdrawal symptoms. This case report highlights the challenges in managing such cases. The patient, with a history of myofascial pain syndrome, hypertension, anxiety, and depression, experienced distressing symptoms, including tachycardia, rebound hypertension, neuropsychiatric manifestations, and involuntary muscle movements...
February 2024: Oxford Medical Case Reports
#34
Mason Hui, Baha Sibai, Alvaro Montealegre, Mateo G Leon
Uterine leiomyomas are common benign smooth muscle tumors that often occur during the reproductive years. Although many cases may not result in significant complications, negative pregnancy outcomes have been associated with the size and location of the fibroids. Degeneration of fibroids can occur as early as the late first trimester when they undergo significant volumetric growth, contributing to pain during pregnancy. While myomectomy is typically avoided during pregnancy, conservative management with anti-inflammatory medications may be effective...
January 2024: American Journal of Perinatology Reports
#35
RANDOMIZED CONTROLLED TRIAL
Samir El Baha, Moutaz Ghandour, Islam S H Ahmed
AIMS: The current study compared a novel technique of scleral indentation using the self-retaining Leyla retractor to the conventional scleral self-indentation with the chandelier light. METHODS: Patients with rhegmatogenous retinal detachment were randomized on a 1:1 basis to either have the (Baha) indentation using a tip of a thimble scleral indenter welded to the support for the Leyla retractor system or to have the conventional scleral indentation while using a 25-gauge chandelier light...
February 17, 2024: International Ophthalmology
#36
REVIEW
Barbara Buccilli, Albert Alan, Baha' Ghandi Aljeradat, Akmal Shahzad, Yasser F Almealawy, Nathan Simbarashe Chisvo, Michelle Ennabe, Martin Weinand
BACKGROUND: This review is centered on the pivotal role of surgical interventions within the comprehensive management of traumatic brain injury (TBI). Surgical strategies are indispensable components of TBI care, encompassing primary injury management and the alleviation of secondary injury processes, including the handling of intracranial hemorrhages (ICHs), contusions, and mass lesions. METHODS: A systematic review was carried out by searching databases including PubMed, Embase, and Scopus...
2024: Surgical Neurology International
#37
REVIEW
Barbara Buccilli, Albert Alan, Aljeradat Baha', Akmal Shahzad, Yasser F Almealawy, Nathan Simbarashe Chisvo, Michelle Ennabe, Martin Weinand
BACKGROUND: This review delves into clinical strategies aimed at addressing the complexities of traumatic brain injury (TBI), specifically focusing on pharmaceutical interventions and stem cell therapies as potential avenues for enhancing TBI outcomes. METHODS: A thorough review of clinical strategies for TBI management, encompassing pharmaceutical and nonpharmaceutical interventions, was performed. PubMed, MEDLINE and clinical trial databases were searched to identify relevant studies and clinical trials...
2024: Surgical Neurology International
#38
REVIEW
Barbara Buccilli, Albert Alan, Aljeradat Baha', Akmal Shahzad, Yasser F Almealawy, Nathan Simbarashe Chisvo, Michelle Ennabe, Martin Weinand
BACKGROUND: Traumatic brain injury (TBI) poses a significant public health concern, profoundly impacting individuals and society. In this context, behavioral interventions have gained prominence as crucial elements in TBI management, addressing the diverse needs of TBI-affected individuals. METHODS: A comprehensive literature search was conducted, utilizing databases such as PubMed, Embase, and Scopus. Inclusion criteria encompassed studies focusing on behavioral interventions in TBI, with a particular emphasis on their impact on outcomes...
2024: Surgical Neurology International
#39
JOURNAL ARTICLE
Christian von Mitzlaff, Ivo Dobrev, Tahmine Farahmandi, Flurin Pfiffner, Christof Röösli
INTRODUCTION: The mechanism of non-osseous bone conduction pathways, involving the intracranial contents (ICC) of the skull, is still not well understood. This study aims to investigate the influence of the ICC on the skull bone wave propagation, including dependence on stimulation location and coupling. METHODS: Three Thiel embalmed whole-head cadaver specimens were studied before and after the removal of the ICC. Stimulation was via the electromagnetic actuators from commercial bone conduction hearing aids...
February 9, 2024: Audiology & Neuro-otology
#40
JOURNAL ARTICLE
Özlem Erçen Diken, Şerife Kaya, Hayriye Bektaş Aksoy, Aydanur Ekici, Aylin Çapraz, Ali Tabaru, Özlem Şengören Dikiş, Hüseyin Arpağ, Hanifi Yildiz, Talat Kiliç, Tarkan Özdemir, Pinar Yildiz Gülhan, Sulhattin Arslan, Nalan Ogan, Canan Doğan, Ümit Tutar, Şeyma Başlilar, Dorina Esendağli, Gamze Kirkil, Ömer Tamer Doğan, Ümran Toru Erbay, Aysun Ayvaci, Mustafa Tosun, Efsun Gonca Uğur Chousein, Elif Yelda Niksarlioğlu, Sabri Serhan Olcay, Tuncer Özkisa, İclal Hocanli, Mehmet Karadağ, Neslihan Özçelik, Nuray Oktay, Elvan Şentürk, Sertaç Arslan, Sibel Pekcan Özyurt, Ahu Cerit, Yasemin Nennicioğlu, Nurhan Atilla, İbrahim Halil Üney, Mehmet Fatih Elverişli, Serdar Berk, Ayşe Baha, Nur Erik, Hasan Ölmez, Berat Kaçmaz, Hüseyin Erzurumluoğlu, Ezgi Demirdöğen Çetinoğlu, Tevfik Özlü
Pulmonology is one of the branches that frequently receive consultation requests from the emergency department. Pulmonology consultation (PC) is requested from almost all clinical branches due to the diagnosis and treatment of any respiratory condition, preoperative evaluation, or postoperative pulmonary problems. The aim of our study was to describe the profile of the pulmonology consultations received from emergency departments in Turkiye. A total of 32 centers from Turkiye (the PuPCEST Study Group) were included to the study...
February 9, 2024: Medicine (Baltimore)
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