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Tendon healing

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https://www.readbyqxmd.com/read/28927769/spontaneous-healing-of-a-tear-of-an-anterior-cruciate-ligament-graft-a-case-report
#1
Natalie Yu Yi Ng, Barry Wei Loong Tan, Lingaraj Krishna
BACKGROUND: Almost 30% of young athletic patients sustain a second anterior cruciate ligament (ACL) injury within 24months of their ACL reconstruction and returning to pivoting sports. Most patients with high athletic demand and significant anteroposterior instability often require ACL revision surgery to restore their pre-injury activity levels. CASE REPORT: A 24-year old gentleman ruptured his hamstring tendon autograft during a twisting injury seven months after his ACL reconstruction...
September 16, 2017: Knee
https://www.readbyqxmd.com/read/28919510/magnesium-mg-based-interference-screws-developed-for-promoting-tendon-graft-incorporation-in-bone-tunnel-in-rabbits
#2
Jiali Wang, Jiankun Xu, Bin Song, Dick Hokiu Chow, Patrick Shu-Hang Yung, Ling Qin
How to enhance tendon graft incorporation into bone tunnels for achieving satisfactory healing outcomes in patients with anterior cruciate ligament reconstruction (ACLR) is one of the most challenging clinical problems in orthopaedic sports medicine. Several studies have recently reported the beneficial effects of Mg implants in bone fracture healing, indicating the use potential of Mg devices in promoting the tendon graft osteointegration. Here, we developed an innovative Mg-based interference screws for fixation of the tendon graft in rabbits underwent ACLR and investigated the biological role of Mg-based implants in the graft healing...
September 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28919215/thermo-responsive-in-situ-forming-hydrogels-as-barriers-to-prevent-post-operative-peritendinous-adhesion
#3
Pang-Yun Chou, Shih-Heng Chen, Chih-Hao Chen, Shih-Hsien Chen, Yi Teng Fong, Jyh-Ping Chen
In this study, we aimed to assess whether thermo-responsive in-situ forming hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) could prevent post-operative peritendinous adhesion. The clinical advantages of the thermo-responsive hydrogels are acting as barrier material to block penetration of fibroblasts, providing mobility and flexibility during application and enabling injection through a small opening to fill spaces of any shape after surgery. The thermo-responsiveness of hydrogels was determined to ensure their clinic uses...
September 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28918438/no-difference-in-outcome-for-open-versus-arthroscopic-rotator-cuff-repair-a-prospective-comparative-trial
#4
Xavier Bayle, Thuy-Trang Pham, Marie Faruch, Aurelie Gobet, Pierre Mansat, Nicolas Bonnevialle
PURPOSE: Arthroscopic techniques tend to become the gold standard in rotator cuff repair. However, little data are reported in the literature regarding the improvement of postoperative outcomes and re-tear rate relative to conventional open surgery. The aim of this study was to compare clinical outcomes and cuff integrity after arthroscopic versus open cuff repair. METHODS: We prospectively assessed clinical outcomes and cuff integrity after an arthroscopic or open rotator cuff repair with a minimum follow-up of 12 months...
September 16, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28905242/poly-n-acetyl-glucosamine-snag-enhances-early-rotator-cuff-tendon-healing-in-a-rat-model
#5
C A Nuss, J Huegel, J F Boorman-Padgett, D S Choi, S N Weiss, J Vournakis, L J Soslowsky
Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. The purpose of this study was to investigate the healing and analgesic properties of sNAG in a rat rotator cuff injury and repair model. 144 adult male Sprague-Dawley rats underwent a transection and repair of their left supraspinatus tendons...
September 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28902861/epigenetic-regulation-of-metalloproteinases-and-their-inhibitors-in-rotator-cuff-tears
#6
Mariana Ferreira Leal, Leonardo Caires Dos Santos, Adrielle Martins de Oliveira, Paulo Santoro Belangero, Eduardo Antônio Figueiredo, Carina Cohen, Felipe de Seixas Alves, Wânia Hiromi Yanaguizawa, Carlos Vicente Andreoli, Alberto de Castro Pochini, Benno Ejnisman, Marília Cardoso Smith, Maria Teresa de Seixas Alves, Moises Cohen
Rotator cuff tear is a common orthopedic condition. Metalloproteinases (MMP) and their inhibitors (TIMP) seem to play a role in the development of joint injuries and in the failure of tissue healing. However, the mechanisms of regulation of gene expression in tendons are still unknown. Epigenetic mechanisms, such as DNA methylation and microRNAs regulation, are involved in the dynamic control of gene expression. Here, the mRNA expression and DNA methylation status of MMPs (MMP1, MMP2, MMP3, MMP9, MMP13, and MMP14) and TIMPs (TIMP1-3) and the expression of miR-29 family members in ruptured supraspinatus tendons were compared with non-injured tendons of individuals without this lesion...
2017: PloS One
https://www.readbyqxmd.com/read/28890257/effects-of-pdgf-bb-delivery-from-heparinized-collagen-sutures-on-the-healing-of-lacerated-chicken-flexor-tendon-in-vivo
#7
Mousa Younesi, Derrick M Knapik, Jameson Cumsky, Baris Ozgur Donmez, Ping He, Anowarul Islam, Greg Learn, Philip McClellan, Michael Bohl, Robert J Gillespie, Ozan Akkus
Flexor tendon lacerations are traditionally repaired by using non-absorbable monofilament sutures. Recent investigations have explored to improve the healing process by growth factor delivery from the sutures. However, it is difficult to conjugate growth factors to nylon or other synthetic sutures. This study explores the performance of a novel electrochemically aligned collagen suture in a flexor tendon repair model with and without platelet derived growth factor following complete tendon laceration in vivo...
September 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28888566/tendon-tissue-engineering-mechanism-and-effects-of-human-tenocyte-coculture-with-adipose-derived-stem-cells
#8
Chao Long, Zhen Wang, Anais Legrand, Arhana Chattopadhyay, James Chang, Paige M Fox
PURPOSE: Adipose-derived stem cells (ASCs) are a potential candidate for cell-based therapy targeting tendon injury; however, their therapeutic benefit relies on their ability to interact with native tenocytes. This study examines the mechanism and effects of coculturing human tenocytes and ASCs. METHODS: Tenocytes (T) were directly cocultured with either ASCs (A) or fibroblasts (F) (negative control) in the following ratios: 50% T/50% A or F; 25% T/75% A or F; and 75% T/25% A or F...
September 6, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28885652/vascularised-and-modified-lower-leg-rotationplasty-for-the-treatment-of-severe-infection-and-bone-loss-of-the-proximal-femur-a-case-report
#9
Sebastian Fischer, Christoph Hirche, Volkmar G Heppert, Paul A Grützner, Ulrich Kneser, Thomas Kremer
CASE DESCRIPTION: We report a reconstructive case in a paraplegic patient, who suffers from a severe proximal femur infection. Aiming at the preservation of the capacity to remain in a seated position to operate a wheelchair, lower leg rotationplasty was considered suitable for reconstruction. Due to severe infection and subclinical femoral artery stenosis, rotationplasty was supercharged by the inferior epigastric artery. Furthermore, extensor tendons of the foot were attached to the acetabulum to facilitate stability of the neo-hip joint...
September 2, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28885384/a-new-stem-guide-and-a-tuberosity-anchoring-lasso-system-for-shoulder-hemiarthroplasty-in-the-treatment-of-complex-proximal-humerus-fractures
#10
Philippe Valenti, Davide Aliani, Charbel Maroun, Jean-David Werthel
Hemiarthroplasty implantation for proximal humerus fracture is challenging. In case of young demanding patients with functional rotator cuff, humeral head replacement is an option if open reduction internal fixation is not a viable solution. The criteria for success in terms of clinical outcomes and longevity are anatomic healing of the tuberosities and stem positioning (restoring correct height, version, and axis). The purpose of this article is to describe a technique including a new stem guide and a tuberosity anchor "lasso" system for the implantation of hemiarthroplasty in complex proximal humerus fractures...
September 6, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28880113/increasing-age-and-tear-size-reduce-rotator-cuff-repair-healing-rate-at-1-year
#11
Mustafa S Rashid, Cushla Cooper, Jonathan Cook, David Cooper, Stephanie G Dakin, Sarah Snelling, Andrew J Carr
Background and purpose - There is a need to understand the reasons why a high proportion of rotator cuff repairs fail to heal. Using data from a large randomized clinical trial, we evaluated age and tear size as risk factors for failure of rotator cuff repair. Patients and methods - Between 2007 and 2014, 65 surgeons from 47 hospitals in the National Health Service (NHS) recruited 447 patients with atraumatic rotator cuff tendon tears to the United Kingdom Rotator Cuff Trial (UKUFF) and 256 underwent rotator cuff repair...
September 7, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28872895/hyaluronic-acid-accelerates-tendon-to-bone-healing-after-rotator-cuff-repair
#12
Hirokazu Honda, Masafumi Gotoh, Tomonoshin Kanazawa, Hiroki Ohzono, Hidehiro Nakamura, Keisuke Ohta, Kei-Ichiro Nakamura, Kanji Fukuda, Takeshi Teramura, Takashi Hashimoto, Shigeki Shichijo, Naoto Shiba
BACKGROUND: There is growing evidence that the subacromial injection of hyaluronic acid (HA) is effective for pain relief in rotator cuff tears; however, its effect on tendon-to-bone healing remains unknown. PURPOSE: To examine the effect of HA on the chondrogenesis of mesenchymal stem cells (MSCs) in vitro and on tendon-to-bone healing in a rotator cuff repair model. STUDY DESIGN: Controlled laboratory study. METHODS: Bilateral complete tears of the infraspinatus tendon were made in rabbits and subsequently repaired...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28866339/arthroscopic-partial-repair-of-irreparable-rotator-cuff-tears-factors-related-to-greater-degree-of-clinical-improvement-at-2%C3%A2-years-of-follow-up
#13
Kun-Hui Chen, En-Rung Chiang, Hsin-Yi Wang, Hsiao-Li Ma
PURPOSE: This study aimed to evaluate the clinical outcomes of irreparable rotator cuff tears (RCT) treated with an arthroscopic partial repair, as well as the preoperative factors that may be related to greater improvement of clinical outcomes at short-term follow-up. METHODS: We retrospectively reviewed patients with irreparable RCT who underwent arthroscopic partial rotator cuff repair between January 2011 and April 2014. Minimal follow-up of 24 months was required...
August 30, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28865569/editorial-commentary-success-of-rotator-cuff-healing-do-we-need-to-improve-on-the-strength-anymore
#14
EDITORIAL
C Benjamin Ma
We have had significant progress in improving the biomechanical strength of arthroscopic rotator cuff repairs over the past 3 decades. The field has advanced from simple suture repairs to double-row, transosseous, massive cuff and rip-stop constructs. I do think our focus next should be on improving the biology of tendon healing to improve our clinical outcomes.
September 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28864251/living-nanofiber-yarn-based-woven-biotextiles-for-tendon-tissue-engineering-using-cell-tri-culture-and-mechanical-stimulation
#15
Shaohua Wu, Ying Wang, Philipp N Streubel, Bin Duan
Non-woven nanofibrous scaffolds have been developed for tendon graft application by using electrospinning strategies. However, electrospun nanofibrous scaffolds face some obstacles and limitations, including suboptimal scaffold structure, weak tensile and suture-retention strengths, and compact structure for cell infiltration. In this work, a novel nanofibrous, woven biotextile, fabricated based on electrospun nanofiber yarns, was implemented as a tissue engineered tendon scaffold. Based on our modified electrospinning setup, polycaprolactone (PCL) nanofiber yarns were fabricated with reproducible quality, and were further processed into plain-weaving fabrics interlaced with polylactic acid (PLA) multifilaments...
August 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28860425/marked-expression-of-tnf-receptors-in-human-peritendinous-tissues-including-in-nerve-fascicles-with-axonal-damage-studies-on-tendinopathy-and-tennis-elbow
#16
C Spang, L Renström, H Alfredson, S Forsgren
BACKGROUND: The peritendinous connective tissues can have importance in chronic tendon pain. Recently cytokine TNF-α has been suggested to be involved in tendinopathic processes. It is not known how TNF-α and its receptors TNFR1 and TNFR2 are expressed in peritendinous tissues. METHODS: The objective for this study was to immunohistochemically evaluate the expression patterns of these in the peritendinous tissue located between the plantaris and Achilles tendons and the one located superficially to the extensor origin at the elbow region for patients with tendinopathy/tennis elbow...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28859517/a-novel-approach-for-meniscal-regeneration-using-kartogenin-treated-autologous-tendon-graft
#17
He Huang, Hongyao Xu, Jianning Zhao
BACKGROUND: The meniscus is one of the most commonly injured parts of the body, and meniscal healing is difficult. HYPOTHESIS: Kartogenin (KGN) induces tendon stem cells (TSCs) to differentiate into cartilage cells in vitro and form meniscus-like tissue in vivo. A damaged meniscus can be replaced with a KGN-treated autologous tendon graft. STUDY DESIGN: Controlled laboratory study. METHODS: In the in vitro experiments, TSCs were isolated from rabbit patellar tendons and cultured with various concentrations of KGN, from 0 to 1000 µM...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28840143/allograft-maturation-after-reconstruction-of-the-anterior-cruciate-ligament-is-dependent-on-graft-parameters-in-the-sagittal-plane
#18
Michael Rose, Dennis Crawford
BACKGROUND: Allograft healing (ligamentization) after reconstruction of the anterior cruciate ligament (ACL) is dependent on multiple factors, including tissue processing, host biologic environment, and biomechanical stressors. Magnetic resonance imaging (MRI) can be used to assess graft maturation after ACL reconstruction. HYPOTHESIS: A significant difference will exist in the MRI analysis between 2 distinct allograft constructs. Specifically, the MRI signal-to-noise quotient (SNQ) value will be smaller in quadrupled hamstring tendon (HT) allografts compared with doubled tibialis anterior (TA) allografts due to the difference in graft geometry (surface area-to-volume ratio)...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28837456/temporal-healing-of-achilles-tendons-after-injury-in-rodents-depends-on-surgical-treatment-and-activity
#19
Benjamin R Freedman, Nabeel S Salka, Tyler R Morris, Pankti R Bhatt, Adam M Pardes, Joshua A Gordon, Courtney A Nuss, Corinne N Riggin, George W Fryhofer, Daniel C Farber, Louis Soslowsky
INTRODUCTION: Achilles tendon ruptures affect 15 of 100,000 women and 55 of 100,000 men each year. Controversy continues to exist regarding optimal treatment and rehabilitation protocols. The objective of this study was to investigate the temporal effects of surgical repair and immobilization or activity on Achilles tendon healing and limb function after complete transection in rodents. METHODS: Injured tendons were repaired (n = 64) or left nonrepaired (n = 64)...
September 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28832206/closed-partial-flexor-digitorum-profundus-rupture-an-unusual-cause-of-pediatric-trigger-finger
#20
Shane R Jackson, Meily Tan, Kim O Taylor
BACKGROUND: Trigger finger is a common condition, causing impaired gliding of the digital flexor tendons. Chronic inflammation is the usual cause, but acute trigger finger following partial tendon laceration has also been described. METHODS: We describe the case of a four year old girl who presented with inability to flex her index finger. Operative exploration revealed a closed partial rupture of the flexor digitorum profundus tendon, catching on the A2 pulley and preventing normal tendon gliding...
September 2017: Hand: Official Journal of the American Association for Hand Surgery
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