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Tendon healing

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https://www.readbyqxmd.com/read/28530157/muscle-secreted-factors-improve-anterior-cruciate-ligament-graft-healing-an-in-vitro-and-in-vivo-analysis
#1
Corina Adriana Ghebes, Nathalie Groen, Yau Chuk Cheuk, Sai Chuen Fu, Hugo Fernandes, Daniel B Saris
One of the ligaments most often damaged during sports - the anterior cruciate ligament (ACL) - has poor healing capacity. Upon damage, reconstructive surgery is performed to restore the mechanical stability of the knee and to reduce the inflammatory milieu otherwise present in the joint. A return to normal activities, however, takes between 9 and 12 months. Thus, strategies capable of improving ACL graft healing are needed. Embryonic development of tendon and ligament (T/L) is regulated by a crosstalk between different cell types...
May 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28509836/make-no-bones-about-it-rotator-cuff-repair-healing-is-not-just-about-the-tendon-commentary-on-an-article-by-shivam-a-shah-phd-et-al-sclerostin-antibody-treatment-enhances-rotator-cuff-tendon-to-bone-healing-in-an-animal-model
#2
https://www.readbyqxmd.com/read/28509826/sclerostin-antibody-treatment-enhances-rotator-cuff-tendon-to-bone-healing-in-an-animal-model
#3
Shivam A Shah, Ioannis Kormpakis, Necat Havlioglu, Michael S Ominsky, Leesa M Galatz, Stavros Thomopoulos
BACKGROUND: Rotator cuff tears are a common source of pain and disability, and poor healing after repair leads to high retear rates. Bone loss in the humeral head before and after repair has been associated with poor healing. The purpose of the current study was to mitigate bone loss near the repaired cuff and improve healing outcomes. METHODS: Sclerostin antibody (Scl-Ab) treatment, previously shown to increase bone formation and strength in the setting of osteoporosis, was used in the current study to address bone loss and enhance rotator cuff healing in an animal model...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28508295/mri-based-tendon-bone-healing-is-related-to-the-clinical-functional-scores-at-the-first-year-after-anterior-cruciate-ligament-reconstruction-with-hamstring-tendon-autograft
#4
Hong-Yun Li, Hong Li, Zi-Ying Wu, Ji-Wu Chen, Shi-Yi Chen
PURPOSE: The correlation between tendon bone healing and clinical functional scores after anterior cruciate ligament reconstruction (ACLR) using four-stranded hamstring tendon autograft has rarely being reported. The purpose of this study was to determine the correlation between magnetic resonance imaging (MRI)-based tendon bone healing and clinical functional scores after ACLR using hamstring tendon. METHODS: Thirty-eight patients with ACLR using four-stranded hamstring tendon autograft were included in this prospective study in the authors' hospital from 2013 to 2014...
May 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28506489/enhancement-of-rotator-cuff-tendon-bone-healing-with-fibroblast-growth-factor-2-impregnated-in-gelatin-hydrogel-sheets-in-a-rabbit-model
#5
Takuya Tokunaga, Tatsuki Karasugi, Hitoshi Arimura, Ryuji Yonemitsu, Hidetoshi Sakamoto, Junji Ide, Hiroshi Mizuta
BACKGROUND: Application of fibroblast growth factor 2 (FGF-2) may improve the healing response after rotator cuff (RC) surgical repair. This study aimed to determine whether FGF-2-impregnated gelatin hydrogel sheet (GHS) incorporation into the bony trough on the greater tuberosity facilitates healing after RC surgical repair in rabbits. METHODS: We assigned 120 adult male Japanese white rabbits treated with unilateral surgery for supraspinatus tendon repair into the following groups: suture-only group (suture); suture and GHS with phosphate-buffered saline (carrier); suture and GHS with 3 µg of FGF-2 (F3); and suture and GHS with 30 µg of FGF-2 (F30)...
May 11, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28506172/the-effect-of-myostatin-gdf-8-on-proliferation-and-tenocyte-differentiation-of-rat-bone-marrow-derived-mesenchymal-stem-cells
#6
Wei Le, Jeffrey Yao
BACKGROUND: The future in flexor tendon surgery involves tissue engineering approaches directed toward increasing early repair strength to accelerate tendon healing and to allow for earlier onset of rehabilitation. Previous work has shown that pluripotential mesenchymal stem cells may be successfully delivered to a tendon repair site using a suture carrier. The current work describes the use of Myostatin (GDF-8) to help guide these delivered pluripotential stem cells to differentiate down a tenocyte lineage to potentially maximize the reparative effects of these cells at the tendon repair site...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28502669/biomimetic-tendon-extracellular-matrix-composite-gradient-scaffold-enhances-ligament-to-bone-junction-reconstruction
#7
Huanhuan Liu, Long Yang, Erchen Zhang, Rui Zhang, Dandan Cai, Shouan Zhu, Jisheng Ran, Varitsara Bunpetch, Youzhi Cai, Boon Chin Heng, Yejun Hu, Xuesong Dai, Xiao Chen, Hongwei Ouyang
Management of ligament/tendon-to-bone-junction healing remains a formidable challenge in the field of orthopedic medicine to date, due to deficient vascularity and multi-tissue transitional structure of the junction. Numerous strategies have been employed to improve ligament-bone junction healing, including delivery of stem cells, bioactive factors, and synthetic materials, but these methods are often inadequate at recapitulating the complex structure-function relationships at native tissue interfaces. Here, we developed an easily-fabricated and effective biomimetic composite to promote the regeneration of ligament-bone junction by physically modifying the tendon extracellular matrix (ECM) into a Random-Aligned-Random composite using ultrasound treatment...
May 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28495756/cystic-fibrosis-transmembrane-conductance-regulator-mediates-tenogenic-differentiation-of-tendon-derived-stem-cells-and-tendon-repair-accelerating-tendon-injury-healing-by-intervening-in-its-downstream-signaling
#8
Yang Liu, Jia Xu, Liangliang Xu, Tianyi Wu, Yuxin Sun, Yuk-Wai Lee, Bin Wang, Hsiao-Chang Chan, Xiaohua Jiang, Jinfang Zhang, Gang Li
Tendons are a mechanosensitive tissue, which enables them to transmit to bone forces that are derived from muscle. Patients with tendon injuries, such as tendinopathy or tendon rupture, were often observed with matrix degeneration, and the healing of tendon injuries remains a challenge as a result of the limited understanding of tendon biology. Our study demonstrates that the stretch-mediated activation channel, cystic fibrosis transmembrane conductance regulator (CFTR), was up-regulated in tendon-derived stem cells (TDSCs) during tenogenic differentiation under mechanical stretching...
May 11, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28489206/lower-extremity-reconstruction-epidemiology-management-and-outcomes-of-patients-of-the-federal-district-north-wing-regional-hospital
#9
Jefferson Lessa Soares Macedo, Simone Corrêa Rosa, Daniel Lobo Botelho, Clendes Pereira Dos Santos, Murilo Neves DE Queiroz, Tabatha Gonçalves Andrade Castelo Branco Gomes
Objective: to evaluate the management of lower limbs complex traumatic injuries by analyzing their characteristics, types, conduct and evolution, with emphasis on surgical treatment. Methods: we conducted a prospective study of patients treated by Plastic Surgery at a regional hospital of the Federal District during a one-year period. We collected data through serial evaluations and telephone contact records. Results: we studied 40 patients, with a mean age of 25...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28483683/the-use-of-dehydrated-human-amnion-chorion-membrane-allograft-injection-for-the-treatment-of-tendinopathy-or-arthritis-a-case-series-involving-40-patients
#10
Alfred C Gellhorn, Alex Han
BACKGROUND: Degenerative joint and tendon injuries remain difficult to treat, with few effective conservative treatment options available. Regenerative approaches aim to promote the inherent healing capacity of injured tissues. Micronized dehydrated human amnion/chorion membrane (dHACM) injection is an emerging regenerative option with promising preclinical results. OBJECTIVE: To test the clinical effectiveness of dHACM injection in patients with chronic tendinopathy and arthropathy...
May 6, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28476390/achilles-tendon-open-surgical-treatment-with-platelet-rich-fibrin-matrix-augmentation-biomechanical-evaluation
#11
Federica Alviti, Michele Gurzì, Valter Santilli, Marco Paoloni, Roberto Padua, Andrea Bernetti, Marco Bernardi, Massimiliano Mangone
The relationship between surgical technique and ankle biomechanical properties after surgery for acute rupture of the Achilles tendon (ATR) has not yet been fully investigated. Platelet-rich fibrin (PRF) matrices seem to play a central role in the complex processes of tendon healing. Our aim was to analyze the biomechanical characteristics, stiffness, and mechanical work of the ankle during walking in patients who had undergone surgery after ATR with and without PRF augmentation. We performed a retrospective review of all consecutive patients who had been treated with surgical repair after ATR...
May 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28470887/rotator-cuff-muscle-degeneration-and-tear-severity-related-to-myogenic-adipogenic-and-atrophy-genes-in-human-muscle
#12
Shivam A Shah, Ioannis Kormpakis, Leonardo Cavinatto, Megan L Killian, Stavros Thomopoulos, Leesa M Galatz
Large rotator cuff tear size and advanced muscle degeneration can affect reparability of tears and compromise tendon healing. Clinicians often rely on direct measures of rotator cuff tear size and muscle degeneration from magnetic resonance imaging (MRI) to determine whether the rotator cuff tear is repairable. The objective of this study was to identify the relationship between gene expression changes in rotator cuff muscle degeneration to standard data available to clinicians. Radiographic assessment of preoperative rotator cuff tear severity was completed for 25 patients with varying magnitudes of rotator cuff tears...
May 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28470843/combination-of-biochemical-and-mechanical-cues-for-tendon-tissue-engineering
#13
Stefano Testa, Marco Costantini, Ersilia Fornetti, Sergio Bernardini, Marcella Trombetta, Dror Seliktar, Stefano Cannata, Alberto Rainer, Cesare Gargioli
Tendinopathies negatively affect the life quality of millions of people in occupational and athletic settings, as well as the general population. Tendon healing is a slow process, often with insufficient results to restore complete endurance and functionality of the tissue. Tissue engineering, using tendon progenitors, artificial matrices and bioreactors for mechanical stimulation, could be an important approach for treating rips, fraying and tissue rupture. In our work, C3H10T1/2 murine fibroblast cell line was exposed to a combination of stimuli: a biochemical stimulus provided by Transforming Growth Factor Beta (TGF-β) and Ascorbic Acid (AA); a three-dimensional environment represented by PEGylated-Fibrinogen (PEG-Fibrinogen) biomimetic matrix; and a mechanical induction exploiting a custom bioreactor applying uniaxial stretching...
May 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28466796/-effect-of-smoking-on-orthopaedic-conditions-an-overview-for-everyday-practice
#14
M F Nieboer, T Gosens
- We are learning more and more about the effects of smoking on orthopaedic conditions such as osteoporosis and osteoarthritis and on healing of fractures and tendons.- Smoking seems to have a slight protective effect on osteoarthritis.- Smokers have a higher risk of postoperative complications such as wound infection, death and prosthesis-related complications.- If smokers stop smoking preoperatively, the risk of general postoperative complications can be reduced, but this is yet to be proven for prosthesis-related complications...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28464787/directed-differentiation-and-paracrine-mechanisms-of-mesenchymal-stem-cells-potential-implications-for-tendon-repair-and-regeneration
#15
Bingyu Zhang, Qing Luo, Alexander Halim, Yang Ju, Yasuyuki Morita, Guanbin Song
Tendon is composed of connective tissue, is able to retract with high tensile force, and plays a significant role in musculoskeletal motion. However, inappropriate physical training or accidents often result in tendon injuries. So far, the functional healing of injured tendon is still a great challenge in orthopedics. Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, including tenocytes. The plasticity of MSCs gives rise to the chance of improved healing of injured tendons and even tissue-engineered tendons...
May 1, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28462460/combined-administration-of-ascs-and-bmp-12-promotes-an-m2-macrophage-phenotype-and-enhances-tendon-healing
#16
Richard H Gelberman, Stephen W Linderman, Rohith Jayaram, Anna D Dikina, Shelly Sakiyama-Elbert, Eben Alsberg, Stavros Thomopoulos, Hua Shen
BACKGROUND: Outcomes after intrasynovial tendon repair are highly variable. An intense inflammatory cascade followed by a delayed healing response can cause adhesion formation and repair-site failure that severely impair the function of repaired digits. No effective remedies exist to fully address these issues. Cell- and growth factor-based therapies have been shown to modulate inflammation and improve cell proliferation and matrix synthesis and therefore are promising treatment approaches for intrasynovial tendon repair...
May 1, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28455604/biological-incorporation-of-human-acellular-dermal-matrix-used-in-achilles-tendon-repair
#17
Giampietro Bertasi, Windy Cole, Brian Samsell, Xiaofei Qin, Mark Moore
Human acellular dermal matrices (ADMs) are used successfully in a variety of procedures, including sports medicine related, wound repair, and breast reconstructions, but the mechanism of repair is still not fully understood. An opportunity to explore this mechanism presented itself when a patient experienced a rerupture of the native tendon due to a fall that occurred 2 months after undergoing an Achilles tendon repair using Matracell treated ADM. The ADM was removed and an extensive histology analysis was performed on the tissue...
April 28, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28451864/prolotherapy-induces-an-inflammatory-response-in-human-tenocytes-in-vitro
#18
Emmanuel C Ekwueme, Mahir Mohiuddin, Jazmin A Yarborough, P Gunnar Brolinson, Denitsa Docheva, Hugo A M Fernandes, Joseph W Freeman
BACKGROUND: Proliferative therapy, or prolotherapy, is a controversial treatment method for many connective tissue injuries and disorders. It involves the injection of a proliferant, or irritant solution, into the site of injury, which causes small-scale cell death. This therapeutic trauma is theorized to initiate the body's wound-healing cascade, perhaps leading to tissue repair. The immediate effects of many of these proliferants are poorly characterized, as are the cellular responses to them; here, we sought to evaluate the immediate effects of two common proliferants (dextrose and P2G, a combination of phenol, glucose, and glycerin) on the cellular response of human tenocytes, and begin to explicate the mechanisms with which each proliferant functions...
April 27, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28451606/ultrasound-and-functional-assessment-of-transtendinous-repairs-of-partial-thickness-articular-sided-rotator-cuff-tears
#19
Roger V Ostrander, Jeffrey M Klauser, Sanjay Menon, Joshua G Hackel
BACKGROUND: Partial-thickness articular-sided rotator cuff tears are a frequent source of shoulder pain. Despite conservative measures, some patients continue to be symptomatic and require surgical management. However, there is some controversy as to which surgical approach results in the best outcomes for grade 3 tears. HYPOTHESIS/PURPOSE: The purpose of this study was to evaluate repair integrity and the clinical results of patients treated with transtendinous repair of high-grade partial-thickness articular-sided rotator cuff tears...
March 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28450316/the-combined-use-of-kartogenin-and-platelet-rich-plasma-promotes-fibrocartilage-formation-in-the-wounded-rat-achilles-tendon-entheses
#20
J Zhang, T Yuan, N Zheng, Y Zhou, M V Hogan, J H-C Wang
OBJECTIVES: After an injury, the biological reattachment of tendon to bone is a challenge because healing takes place between a soft (tendon) and a hard (bone) tissue. Even after healing, the transition zone in the enthesis is not completely regenerated, making it susceptible to re-injury. In this study, we aimed to regenerate Achilles tendon entheses (ATEs) in wounded rats using a combination of kartogenin (KGN) and platelet-rich plasma (PRP). METHODS: Wounds created in rat ATEs were given three different treatments: kartogenin platelet-rich plasma (KGN-PRP); PRP; or saline (control), followed by histological and immunochemical analyses, and mechanical testing of the rat ATEs after three months of healing...
April 2017: Bone & Joint Research
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