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Tendon healing

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https://www.readbyqxmd.com/read/29149506/integrating-soft-and-hard-tissues-via-interface-tissue-engineering
#1
REVIEW
Sahishnu Patel, Jon-Michael Caldwell, Stephen B Doty, William N Levine, Scott Rodeo, Louis J Soslowsky, Stavros Thomopoulos, Helen H Lu
The enthesis, or interface between bone and soft tissues such as ligament and tendon, is prone to injury and often does not heal post-surgical intervention. Interface tissue engineering represents an integrative strategy for regenerating the native enthesis by functionally connecting soft and hard tissues and thereby improving clinical outcome. This review focuses on integrative and cell-instructive scaffold designs that target the healing of the two most commonly injured soft tissue-bone junctions: the tendon-bone interface (e...
November 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29147741/achilles-tendon-elastic-properties-remain-decreased-in-long-term-after-rupture
#2
B Frankewycz, A Penz, J Weber, N P da Silva, F Freimoser, R Bell, M Nerlich, E M Jung, D Docheva, C G Pfeifer
PURPOSE: Rupture of the Achilles tendon results in inferior scar tissue formation. Elastography allows a feasible in vivo investigation of biomechanical properties of the Achilles tendon. The purpose of this study is to investigate the biomechanical properties of healed Achilles tendons in the long term. MATERIALS AND METHODS: Patients who suffered from Achilles tendon rupture were recruited for an elastographic evaluation. Unilateral Achilles tendon ruptures were included and scanned in the mid-substance and calcaneal insertion at least 2 years after rupture using shear wave elastography...
November 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29146168/bone-marrow-derived-mesenchymal-stromal-cells-enhanced-by-platelet-rich-plasma-maintain-adhesion-to-scaffolds-in-arthroscopic-simulation
#3
Alexander R Hoberman, Carl Cirino, Mary Beth McCarthy, Mark P Cote, Leo Pauzenberger, Knut Beitzel, Augustus D Mazzocca, Felix Dyrna
PURPOSE: To assess the response of bone marrow-derived mesenchymal stromal cells (bMSCs) enhanced by platelet-rich plasma (PRP) in the setting of a normal human tendon (NHT), a demineralized bone matrix (DBM), and a fibrin scaffold (FS) with simulated arthroscopic mechanical washout stress. METHODS: Bone marrow was aspirated from the humeral head and concentrated. BMSCs were counted, plated, and grown to confluence. Cells were seeded onto 3 different scaffolds: (1) NHT, (2) DBM, and (3) FS...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29140140/the-physiological-mechanisms-of-effect-of-vitamins-and-amino-acids-on-tendon-and-muscle-healing-a-systematic-review
#4
Christopher Tack, Faye Shorthouse, Lindsy Kass
AIMS/OBJECTIVES: To evaluate current literature via systematic review to ascertain whether amino acids/ vitamins provide any influence on musculotendinous healing, and by which physiological mechanisms Methods: EBSCO, PUBMED, Science Direct, Embase Classic/ Embase, and MEDLINE were searched using terms including "vitamins", "amino acids", "healing", "muscle" and "tendon". The primary search had 479 citations, 466 of which were excluded predominantly due to non-randomised design. Randomised human and animal studies investigating all supplement types/ forms of administration were included...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29124078/demineralized-bone-matrix-to-augment-tendon-bone-healing-a-systematic-review
#5
Adam T Hexter, Catherine Pendegrass, Fares Haddad, Gordon Blunn
Background: Following injury to the rotator cuff and anterior cruciate ligament, a direct enthesis is not regenerated, and healing occurs with biomechanically inferior fibrous tissue. Demineralized bone matrix (DBM) is a collagen scaffold that contains growth factors and is a promising biological material for tendon and ligament repair because it can regenerate a direct fibrocartilaginous insertion via endochondral ossification. Purpose: To provide a comprehensive review of the literature investigating the use of DBM to augment tendon-bone healing in tendon repair and anterior cruciate ligament reconstruction (ACLR)...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29118899/alterations-in-tendon-microenvironment-in-response-to-mechanical-load-potential-molecular-targets-for-treatment-strategies
#6
REVIEW
Mohamed B Fouda, Finosh G Thankam, Matthew F Dilisio, Devendra K Agrawal
Rotator cuff (RC) tendons could beinflicted in many ways with an eventual outcome of pain, weakness and disability, which represent a large burden on health care cost. However, optimal healing, either conservatively or with surgical intervention, remains an issue that needs further investigation. Disorders of the RC tendons may result from external factors like trauma, or internal factors through physiologic and metabolic derangement. Most RC tendon disorders may be asymptomatic and may result from an over-activity of the inflicted shoulder and its tendons...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29111420/viscoelastic-shear-lag-model-to-predict-the-micromechanical-behavior-of-tendon-under-dynamic-tensile-loading
#7
Jiayu Wu, Hong Yuan, Longyuan Li, Kunjie Fan, Shanguang Qian, Bing Li
Owing to its viscoelastic nature, tendon exhibits stress rate-dependent breaking and stiffness function. A Kelvin-Voigt viscoelastic shear lag model is proposed to illustrate the micromechanical behavior of the tendon under dynamic tensile conditions. Theoretical closed-form expressions are derived to predict the deformation and stress transfer between fibrils and interfibrillar matrix while tendon is dynamically stretched. The results from the analytical solutions demonstrate that how the fibril overlap length and fibril volume fraction affect the stress transfer and mechanical properties of tendon...
October 27, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29101577/tendon-pathology-in-hypercholesterolemia-and-familial-hypercholesterolemia
#8
REVIEW
Brittany Taylor, Adnan Cheema, Louis Soslowsky
PURPOSE OF REVIEW: Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level...
November 4, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29100398/tenomodulin-highly-expressing-mscs-as-a-better-cell-source-for-tendon-injury-healing
#9
Yonghui Hou, Ming Ni, Sien Lin, Yuxin Sun, Weiping Lin, Yamei Liu, Haibin Wang, Wei He, Gang Li, Liangliang Xu
Tendon injuries are common orthopedic problems which may cause severe morbidity. MSCs (mesenchymal stem cells) have shown promising effect on tissue engineering and have been used for the treatment of tendon injury. But the low tenogenic differentiation capacity of MSCs have hindered their application. In the present study, we have constructed the Tenomodulin (Tnmd) promoter-driven GFP expression lentiviral plasmid. After transduced into BMSCs, the expression of GFP was used to select BMSCs highly expressing Tnmd by flow cytometry...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29094396/polydeoxyribonucleotide-improves-tendon-healing-following-achilles-tendon-injury-in-rats
#10
Shin Hyuk Kang, Min Seok Choi, Han Koo Kim, Woo Seob Kim, Tae Hui Bae, Mi Kyung Kim, Seung Hwan Chang
Tendon injuries are major musculoskeletal disorders. Polydeoxyribonucleotide activates the adenosine receptor subtype A2A, resulting in tissue growth and neogenesis. This experimental study confirms that polydeoxyribonucleotide can improve secretion of various growth factors, promote collagen synthesis, and restore tensile strength of the Achilles tendon in a rat model with Achilles tendon injury. Thirty-six male Sprague-Dawley rats, aged 7 weeks, were divided into two groups, and the Achilles tendon was transected and repaired using the modified Kessler's method...
November 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29083359/treatment-of-dorsal-fracture-dislocation-of-the-proximal-interphalangeal-joint-using-the-ligamentotaxor-device-clinical-and-radiographic-preliminary-results
#11
Francesco Kostoris, Gianluca Canton, Emiliano Longo, Francesco Romano, Luigi Murena
BACKGROUND AND AIM OF THE WORK: Fracture-dislocations of the proximal interphalangeal joint are complex injuries, often difficult to treat. Several treatment options have been described. Among them dynamic external fixation proved to be a safe technique leading to good results in many authors experience. The principles of this treatment are to avoid edema, prevent stiffness and tendon adhesions, promote joint remodelling and facilitate rehabilitation. The Ligamentotaxor® device is a simple and reproducible dynamic external fixation system that has been used in recent years to treat proximal interphalangeal joint fracture-dislocations, with favourable results...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29079961/in-achilles-tendinopathy-the-neovascularization-detected-by-contrast-enhanced-ultrasound-ceus-is-abundant-but-not-related-to-symptoms
#12
Armanda De Marchi, Simona Pozza, Enzo Cenna, Franco Cavallo, Giorgia Gays, Luca Simbula, Paola De Petro, Alessandro Massè, Giuseppe Massazza
PURPOSE AND HYPOTHESIS: Mid-portion Achilles tendinopathy is characterized by a proliferation of small vessels, called neovascularization, which can be demonstrated by power Doppler sonography (PD). Neovascularization can be correlated with diagnosis and consequent therapies focused on vascular supply. Published data regarding the relationship between neovascularisation and symptoms, such as pain and disability, are contradictory. The hypothesis that contrast-enhanced ultrasound (CEUS) could detect with more sensibility than PD the new vessel ingrowth in human degenerated Achilles tendons and therefore the correlation of neovascularization with pain and disability, was evaluated...
October 27, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29079910/the-effect-of-rotator-cuff-malreduction-on-tendon-tension-an-evaluation-of-a-custom-made-digital-tensiometer-clamp
#13
Marc-Frederic Pastor, Manuel Kraemer, Michael Schwarze, Christof Hurschler, Tomas Smith, Mathias Wellmann
INTRODUCTION: Rotator cuff tears are common and good-to-excellent clinical outcome is reported after subsequent repair. However, the retear rate of rotator cuff repairs has been shown to be as high as 20%. The reasons for retear seem to be multifactorial, mainly comprised by mechanical and biological aspects. Regarding mechanical causes, the role of the tendon tension and malreduction is so far unknown. First, we hypothesized that the tendon tension depends on the technique of tendon reposition and that malreduction of the tendon results in an increased tendon tension...
October 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29078727/proximal-phalanx-fracture-management
#14
Tim T Lögters, Hannah H Lee, Sebastian Gehrmann, Joachim Windolf, Robert A Kaufmann
BACKGROUND: The goal of proximal phalangeal fracture management is to allow for fracture healing to occur in acceptable alignment while maintaining gliding motion of the extensor and flexor tendons. METHODS: We reviewed the most current literature on various treatment methods of proximal phalanx fractures, focusing on the indications and outcomes of nonoperative as well as operative interventions. RESULTS: Stable fractures can be successfully treated nonoperatively, whereas unstable injuries benefit from surgery...
October 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29067092/effect-of-tendon-hydrogel-on-healing-of-tendon-injury
#15
Zheng Chen, Yongjun Rui, Yajun Xu, Quanrong Zhang, Zhenzhong Sun, Jiandong Zhou, Xueming Chen
Hand trauma arising from postoperative acute or chronic tendon injuries leads to delayed union and is one of the greatest challenges in clinical practice. The present study hypothesized that an extracellular matrix hydrogel made from tendons can promote tendon healing and improve tissue regeneration. To verify this, 36 Wistar rats were subjected to bilateral full-thickness injury of their Achilles tendons, starting from the heel bone along the center line to remove a segment of 5 mm in length and 0.5 mm in width...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29059116/management-of-failed-rotator-cuff-repair-in-young-patients
#16
Bassem T Elhassan, Ryan M Cox, Dave R Shukla, Julia Lee, Anand M Murthi, Robert Z Tashjian, Joseph A Abboud
Management of failed rotator cuff repair may be difficult, especially in young patients. Various nonmodifiable and modifiable patient factors, including age, tendon quality, rotator cuff tear characteristics, acute or chronic rotator cuff tear, bone quality, tobacco use, and medications, affect rotator cuff repair healing. Surgical variables, such as the technique, timing, tension on the repair, the biomechanical construct, and fixation, as well as the postoperative rehabilitation strategy also affect rotator cuff repair healing...
November 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29056022/-clinical-effects-of-middle-and-low-peroneal-artery-perforator-flap-with-pedicle-on-repairing-skin-and-soft-tissue-defects-of-ankle
#17
H Li, C Zhang, C L Deng, X J Tang, K Y Nie, Z R Wei
Objective: To investigate clinical effects of middle and low peroneal artery perforator flap with pedicle on repairing skin and soft tissue defects of ankle. Methods: Twenty patients with skin and soft tissue defects of ankle and exposure of tendon and bone were admitted in our burn wards from April 2012 to December 2015. The size of skin and soft tissue defects ranged from 5 cm×4 cm to 23 cm×10 cm. Patients were treated with debridement and vacuum sealing drainage (VSD) after admission. After VSD treatment for 1 week, flap transplantation operation was performed...
October 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29055701/self-healing-and-tough-hydrogels-with-physically-cross-linked-triple-networks-based-on-agar-pva-graphene
#18
Navid Samadi, Mohammad Sabzi, Masoud Babaahmadi
The aim of this work was to prepare polyvinyl alcohol (PVA)/Agar/Graphene nanocomposite hydrogels through a one-pot and green solution mixing method using water as solvent. Herein a novel strategy for designing stiff, tough and self-healing triple network (TN) hydrogels was proposed. The prepared TN hydrogels composed of strong Agar polysaccharide as the first network, tough PVA biopolymer gel as the second network, and graphene nanoplatelets as the third network. Interestingly, similar to natural biomaterials, all of the networks of the nanocomposite hydrogel were physically cross-linked via dynamic hydrogen bonding associations, i...
October 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29053925/mesenchymal-stem-cell-secretome-improves-tendon-cell-viability-in-vitro-and-tendon-bone-healing-in-vivo-when-a-tissue-engineering-strategy-is-used-in-a-rat-model-of-chronic-massive-rotator-cuff-tear
#19
Nuno Sevivas, Fábio Gabriel Teixeira, Raquel Portugal, Bruno Direito-Santos, João Espregueira-Mendes, Filipe J Oliveira, Rui F Silva, Nuno Sousa, Wan Ting Sow, Luong T H Nguyen, Kee Woei Ng, António J Salgado
BACKGROUND: Massive rotator cuff tears (MRCTs) represent a major clinical concern, especially when degeneration and chronicity are involved, which highly compromise healing capacity. PURPOSE: To study the effect of the secretome of mesenchymal stem cells (MSCs) on tendon cells (TCs) followed by the combination of these activated TCs with an electrospun keratin-based scaffold to develop a tissue engineering strategy to improve tendon-bone interface (TBi) healing in a chronic MRCT rat model...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29053586/time-dependent-alterations-of-mmps-timps-and-tendon-structure-in-human-achilles-tendons-after-acute-rupture
#20
Susann Minkwitz, Aysha Schmock, Alper Kurtoglu, Serafeim Tsitsilonis, Sebastian Manegold, Britt Wildemann, Franka Klatte-Schulz
A balance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) is required to maintain tendon homeostasis. Variation in this balance over time might impact on the success of tendon healing. This study aimed to analyze structural changes and the expression profile of MMPs and TIMPs in human Achilles tendons at different time-points after rupture. Biopsies from 37 patients with acute Achilles tendon rupture were taken at surgery and grouped according to time after rupture: early (2-4 days), middle (5-6 days), and late (≥7 days), and intact Achilles tendons served as control...
October 20, 2017: International Journal of Molecular Sciences
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