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Tendon healing

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https://www.readbyqxmd.com/read/28427319/mechanobiological-modelling-of-tendons-review-and-future-opportunities
#1
Mark S Thompson, M Nazri Bajuri, Hanifeh Khayyeri, Hanna Isaksson
Tendons are adapted to carry large, repeated loads and are clinically important for the maintenance of musculoskeletal health in an increasing, actively ageing population, as well as in elite athletes. Tendons are known to adapt to mechanical loading. Also, their healing and disease processes are highly sensitive to mechanical load. Computational modelling approaches developed to capture this mechanobiological adaptation in tendons and other tissues have successfully addressed many important scientific and clinical issues...
May 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28420425/acceleration-of-tendon-bone-healing-of-anterior-cruciate-ligament-graft-using-intermittent-negative-pressure-in-rabbits
#2
Zhengming Sun, Xiaoqing Wang, Ming Ling, Wei Wang, Yanhai Chang, Guang Yang, Xianghui Dong, Shixun Wu, Xueyuan Wu, Bo Yang, Ming Chen
BACKGROUND: The purpose of this study was to test effects of negative pressure on tendon-bone healing after reconstruction of anterior cruciate ligament (ACL) in rabbits. METHODS: Hind legs of 24 New Zealand White rabbits were randomly selected as negative pressure group and the contralateral hind legs as control. Reconstruction of the ACL was done. Joints of the negative pressure side were placed with drainage tubes connecting the micro-negative pressure aspirator...
April 18, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28419543/aging-does-not-alter-tendon-mechanical-properties-during-homeostasis-but-does-impair-flexor-tendon-healing
#3
Jessica E Ackerman, Ibrahima Bah, Jennifer H Jonason, Mark R Buckley, Alayna E Loiselle
Aging is an important factor in disrupted homeostasis of many tissues. While an increased incidence of tendinopathy and tendon rupture are observed with aging, it is unclear whether this is due to progressive changes in tendon cell function and mechanics over time, or an impaired repair reaction from aged tendons in response to insult or injury. In the present study we examined changes in the mechanical properties of Flexor Digitorum Longus (FDL), Flexor Carpi Ulnaris (FCU), and tail fascicles in both male and female C57Bl/6 mice between 3-27 months of age to better understand the effects of sex and age on tendon homeostasis...
April 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28418825/science-to-practice-quantitative-us-elastography-can-be-used-to-quantify-mechanical-and-histologic-tendon-healing-in-a-rabbit-model-of-achilles-tendon-transection
#4
Kenneth S Lee, Jack Martin, Darryl Thelen
Compression-based ultrasonographic (US) elastography is associated with time-dependent mechanical and histologic changes of the healing tendon in a transected rabbit model of the Achilles tendon. This finding will lead to continued development of quantitative US, which can be used to objectively assess a diseased or healing tendon. With advances in the method used, clinical translation of tendon elastography may enable clinicians to diagnose tendon damage and track healing, which should improve both treatment and outcome...
May 2017: Radiology
https://www.readbyqxmd.com/read/28409108/hamstring-graft-biological-preparation-for-anterior-cruciate-ligament-reconstruction
#5
Nuno Camelo Barbosa, Francisco Guerra-Pinto, Claudia Cabeleira, Pedro Beja da Costa
The all-inside anterior cruciate ligament reconstruction (ACLR) success depends on biologic integration of the graft in the bone tunnel. Sutures wrapping the tendon in the bone tunnel may affect tendon-bone healing in shorter bone tunnels. To achieve better graft integration, we propose a variation of the graft link suture technique wherein the graft is linked chain-like to the femoral and tibial TightRope (Arthrex), which increases the tendon-bone contact area by eliminating sutures from the noose of the graft and thus may allow better graft integration...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28407683/the-effects-of-high-glucose-on-tendon-derived-stem-cells-implications-of-the-pathogenesis-of-diabetic-tendon-disorders
#6
Yu-Cheng Lin, Ying-Juan Li, Yun-Feng Rui, Guang-Chun Dai, Liu Shi, Hong-Liang Xu, Ming Ni, Song Zhao, Hui Chen, Chen Wang, Gang Li, Gao-Jun Teng
Patients with diabetes are at great risk to suffer many musculoskeletal disorders, such as tendinopathy, tendon rupture and impaired tendon healing. However, the pathogenesis of these tendon disorders still remains unclear. In this study, we aimed to investigate the effects of high glucose on cell proliferation, cell apoptosis and tendon-related markers expression of tendon-derived stem cells (TDSCs) in vitro. These findings might provide new insights into the pathogenesis of diabetic tendon disorders. The cell proliferative ability and apoptosis rate of TDSCs in different groups were evaluated by MTT assay and Annexin V-FITC/PI staining assay...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402758/the-graft-bending-angle-can-affect-early-graft-healing-after-anterior-cruciate-ligament-reconstruction-in-vivo-analysis-with-2-years-follow-up
#7
Yasutaka Tashiro, Tom Gale, Vani Sundaram, Kanto Nagai, James J Irrgang, William Anderst, Yasuharu Nakashima, Scott Tashman, Freddie H Fu
BACKGROUND: A high graft bending angle (GBA) after anterior cruciate ligament (ACL) reconstruction has been suggested to cause stress on the graft. Nevertheless, evidence about its effect on graft healing in vivo is limited. HYPOTHESIS: The signal intensity on magnetic resonance imaging (MRI) would be higher in the proximal region of the ACL graft, and higher signals would be correlated to a higher GBA. STUDY DESIGN: Descriptive laboratory study...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28400883/rehabilitation-after-rotator-cuff-repair
#8
REVIEW
Ourania Nikolaidou, Stefania Migkou, Christos Karampalis
BACKGROUND: Rotator cuff tears are a very common condition that is often incapacitating. Whether non-surgical or surgical, successful management of rotator cuff disease is dependent on appropriate rehabilitation. If conservative management is insufficient, surgical repair is often indicated. Postsurgical outcomes for patients having had rotator cuff repair can be quite good. A successful outcome is much dependent on surgical technique as it is on rehabilitation. Numerous rehabilitation protocols for the management of rotator cuff disease are based primarily on clinical experience and expert opinion...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28400878/the-impact-of-re-tear-on-the-clinical-outcome-after-rotator-cuff-repair-using-open-or-arthroscopic-techniques-a-systematic-review
#9
REVIEW
Ilias Galanopoulos, Aslanidis Ilias, Konstantinos Karliaftis, Dimitrios Papadopoulos, Neil Ashwood
BACKGROUND: It is generally accepted that rotator cuff repair gives satisfactory results in the long term, although most studies have so far shown a fairly high rate of structural failure or re-tear. The purpose of this review study is to assess whether failure of the repaired cuff to heal could negatively affect the functional outcome. METHODS: This article includes an extensive Internet PubMed based research in the current English-language literature including level I to level V studies as well as systematic reviews...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28399392/the-use-of-acellular-urinary-bladder-matrix-as-coverage-for-fasciocutaneous-free-flap-donor-sites-an-alternative-to-traditional-grafting-procedures
#10
James C Melville, Nicholas A Bennetts, Lauro Tijerina, Jonathan W Shum
PURPOSE: The purpose of this review is to 1) evaluate our early experience with urinary bladder matrix as a dressing for the management of complex wounds subsequent to fasciocutaneous or osteocutaneous vascularized tissue harvests, 2) assess coverage of exposed tendons and the duration of granulation and epithelial coverage, and 3) assess esthetic and functional outcomes compared with traditional means for the management of vascularized tissue harvest sites. PATIENTS AND METHODS: This prospective study consisted of 8 consecutive patients in whom a substantial cutaneous component was harvested as part of a vascularized tissue reconstruction, which did not permit for primary closure (n = 7) or had skin graft failure (exposed tendon) that required additional treatment (n = 1)...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28398948/angiopoietin-like-4-enhances-the-proliferation-and-migration-of-tendon-fibroblasts
#11
Sarwat Jamil, Rouhollah Mousavizadeh, Mani Roshan-Moniri, Scott J Tebbutt, Robert G McCormack, Vincent Duronio, Alex Scott
PURPOSE: Angiopoietin-like 4 (ANGPTL4) is known to play a variety of roles in the response to exercise, and more recently has been shown to enhance the healing of tendon, a fibrous load-bearing tissue required for efficient movement. The objective of the current study was to further explore the mechanisms of ANGPTL4's impact on tendon cells using a gene array approach. METHODS: Human tendon fibroblasts were treated with recANGPTL4 and their global transcriptome response analyzed after 4 and 24 hours...
April 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28396584/a-high-glucose-diet-affects-achilles-tendon-healing-in-rats
#12
Stefanie Korntner, Nadja Kunkel, Christine Lehner, Renate Gehwolf, Andrea Wagner, Peter Augat, Daniel Stephan, Verena Heu, Hans-Christian Bauer, Andreas Traweger, Herbert Tempfer
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positive effect of nutritional interventions on tendon health and repair. With this study, we aim to reveal effects of a high-glucose diet on tendon neoformation in a non-diabetic rat model of Achilles tenotomy. After surgery animals received either a high-glucose diet or a control diet for 2 and 4 weeks, respectively...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28395947/efficacy-of-bone-marrow-stimulating-technique-in-rotator-cuff-repair
#13
Kerem Bilsel, Fatih Yildiz, Mehmet Kapicioglu, Gokcer Uzer, Mehmet Elmadag, Anil Pulatkan, Mukaddes Esrefoglu, Ergun Bozdag, Giuseppe Milano
BACKGROUND: This study used a chronic rotator cuff (RC) tear model to investigate the effect of microfracture as a bone marrow-stimulating (BMS) technique for RC healing. METHODS: A chronic retracted RC tendon tear model was created bilaterally in the subscapularis tendons of 20 New Zealand rabbits. The tendons were repaired after 8 weeks using a single-row configuration. Tendons in the right shoulder were repaired in standard fashion (control group). Microfractures were performed in the left shoulders before repair (microfracture group)...
April 7, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28390662/influence-of-aging-on-microvascular-supply-of-the-gluteus-medius-tendon-a-cadaveric-and-histologic-study
#14
William H Márquez-Arabia, Juan Gómez-Hoyos, Marcela Gómez, Isabel Flórez, Jaime A Gallo, Francisco Monsalve, Luis F Arias, Hal D Martin
PURPOSE: The purpose of this cadaveric study was to assess the relation between age and microvascular supply of 3 areas of the gluteus medius tendon using a previously validated CD31 immunohistochemistry staining technique. METHODS: Twenty-four fresh-frozen gluteus medius specimens were obtained through a posterolateral approach to the hip. Specimens aged 18 years or older, of either sex, and of any race were considered for this study. The average age of donors was 47...
April 5, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28387435/collagen-v-haploinsufficiency-in-a-murine-model-of-classic-ehlers-danlos-syndrome-is-associated-with-deficient-structural-and-mechanical-healing-in-tendons
#15
Jessica M Johnston, Brianne K Connizzo, Snehal S Shetye, Kelsey A Robinson, Julianne Huegel, Ashley B Rodriguez, Mei Sun, Sheila M Adams, David E Birk, Louis J Soslowsky
Classic Ehlers-Danlos syndrome (EDS) patients suffer from connective tissue hyperelasticity, joint instability, skin hyperextensibility, tissue fragility, and poor wound healing due to heterozygous mutations in COL5a1 or COL5a2 genes. This study investigated the roles of collagen V in establishing structure and function in uninjured patellar tendons as well as in the injury response using a Col5a1(+/-) mouse, a model for classic EDS. These analyses were done comparing tendons from a classic EDS model (Col5a1(+/-) ) with wild type controls...
April 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28378372/microcirculation-after-achilles-tendon-rupture-correlates-with-functional-and-patient-reported-outcome
#16
Praxitelis Praxitelous, Gunnar Edman, Paul W Ackermann
INTRODUCTION: Patients with acute Achilles tendon rupture (ATR) display an extended healing process with varying clinical outcome. Poor microcirculatory blood flow has been suggested to be a significant factor for the healing process. However, whether microcirculation may predict healing outcome has been mostly unknown. Therefore, we investigated if blood flow in the Achilles tendon may be associated with patient-reported and functional outcomes after ATR. METHODS: In vivo laser Doppler flowmetry was used to assess microvascular blood flow bilateral in the Achilles tendons, during post-occlusive reactive hyperemia, of nine patients with acute total ATR at two weeks post-operatively...
April 4, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28373942/surgical-technique-to-repair-musculotendinous-junction-tear-of-supraspinatus-using-lateral-row-anchors-to-avoid-cut-through
#17
Bancha Chernchujit, Prashant H Parate
A musculotendinous junction tear is a rare type of rotator cuff tear. There is very little literature available on musculotendinous junction tears. We propose a technique for repair of this type of tear using lateral-row anchors. In this technique, the torn tendon is freshened and sutures are passed through the medial part of the torn tendon. When it is fixed with lateral-row anchors, the tear is reduced and tendon-to-tendon healing is seen. The enthesis and the tendon length are preserved.
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28369181/apoptosis-and-rotator-cuff-tears-scientific-evidence-from-basic-science-to-clinical-findings
#18
Leonardo Osti, Matteo Buda, Angelo Del Buono, Raffaella Osti, Leo Massari, Nicola Maffulli
Introduction: Excessive apoptosis has been hypothesized as possible cause of tendinopathy and tear in the tendons of the rotator cuff (RC). Different mechanisms and molecules play a key role in cell regulation. Biological interventions can affect the process of apoptosis to control the tendinopathy process, and may be useful to design new treatments. Source of data: We identified basic science, in vitro and in vivo preclinical and clinical studies listed in the Pubmed Google Scholar, CINAHL, Cochrane Central and Embase Biomedical databases in English, Spanish, Italian and French concerning the effects of apoptosis on RC tendons...
March 24, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28369135/engineered-stem-cell-niche-matrices-for-rotator-cuff-tendon-regenerative-engineering
#19
M Sean Peach, Daisy M Ramos, Roshan James, Nicole L Morozowich, Augustus D Mazzocca, Steven B Doty, Harry R Allcock, Sangamesh G Kumbar, Cato T Laurencin
Rotator cuff (RC) tears represent a large proportion of musculoskeletal injuries attended to at the clinic and thereby make RC repair surgeries one of the most widely performed musculoskeletal procedures. Despite the high incidence rate of RC tears, operative treatments have provided minimal functional gains and suffer from high re-tear rates. The hypocellular nature of tendon tissue poses a limited capacity for regeneration. In recent years, great strides have been made in the area of tendonogenesis and differentiation towards tendon cells due to a greater understanding of the tendon stem cell niche, development of advanced materials, improved scaffold fabrication techniques, and delineation of the phenotype development process...
2017: PloS One
https://www.readbyqxmd.com/read/28366437/mechanical-histological-and-functional-properties-remain-inferior-in-conservatively-treated-achilles-tendons-in-rodents-long-term-evaluation
#20
Benjamin R Freedman, George W Fryhofer, Nabeel S Salka, Harina A Raja, Cody D Hillin, Courtney A Nuss, Daniel C Farber, Louis J Soslowsky
Conservative treatment (non-operative) of Achilles tendon ruptures is suggested to produce equivalent capacity for return to function; however, long term results and the role of return to activity (RTA) for this treatment paradigm remain unclear. Therefore, the objective of this study was to evaluate the long term response of conservatively treated Achilles tendons in rodents with varied RTA. Sprague Dawley rats (n=32) received unilateral blunt transection of the Achilles tendon followed by randomization into groups that returned to activity after 1-week (RTA1) or 3-weeks (RTA3) of limb casting in plantarflexion, before being euthanized at 16-weeks post-injury...
May 3, 2017: Journal of Biomechanics
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