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Tendon healing

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https://www.readbyqxmd.com/read/28214894/mechanical-loading-improves-tendon-bone-healing-in-a-rabbit-anterior-cruciate-ligament-reconstruction-model-by-promoting-proliferation-and-matrix-formation-of-mesenchymal-stem-cells-and-tendon-cells
#1
Fanglong Song, Dawei Jiang, Tianchen Wang, Yi Wang, Fengmei Chen, Guoxing Xu, Yifan Kang, Yinquan Zhang
BACKGROUND/AIMS: This study investigated the effect of mechanical stress on tendon-bone healing in a rabbit anterior cruciate ligament (ACL) reconstruction model as well as cell proliferation and matrix formation in co-culture of bone-marrow mesenchymal stem cells (BMSCs) and tendon cells (TCs). METHODS: The effect of continuous passive motion (CPM) therapy on tendon-bone healing in a rabbit ACL reconstruction model was evaluated by histological analysis, biomechanical testing and gene expressions at the tendon-bone interface...
February 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214835/up-regulation-of-tgf-%C3%AE-promotes-tendon-to-bone-healing-after-anterior-cruciate-ligament-reconstruction-using-bone-marrow-derived-mesenchymal-stem-cells-through-the-tgf-%C3%AE-mapk-signaling-pathway-in-a-new-zealand-white-rabbit-model
#2
Rui Wang, Bin Xu, Hong-Gang Xu
BACKGROUND/AIMS: This study aimed to explore the role of TGF-β in tendon-to-bone healing after anterior cruciate ligament (ACL) reconstruction using bone marrow-derived mesenchymal stem cells (BMSCs) through the TGF-β/MAPK signaling pathway in a New Zealand white rabbit model. METHODS: A total of 72 healthy male New Zealand white rabbits were selected for these experiments. Flow cytometry and immunofluorescence were used to detect the expression of BMSC surface markers, and qRT-PCR was performed to detect TGF-β mRNA expression...
January 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28212989/arthroscopic-suture-repair-of-acute-quadriceps-tendon-ruptures
#3
M Severyns, G Renard, R Guillou, G A Odri, O Labrada-Blanco, J L Rouvillain
Acute quadriceps tendon ruptures disrupt the continuity of the extensor mechanism and must be treated surgically. Tendon reattachment with suture anchors has recently been shown to be biomechanically superior to reattachment through transosseous tunnels. In this context, arthroscopy is an interesting alternative. It can limit postoperative wound healing and infectious complications, while ensuring functional outcomes that are equivalent to standard techniques. The goal of this technical note is to describe an original, reproducible method for arthroscopic reattachment of the quadriceps tendon with suture anchors...
February 14, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28205467/a-rare-type-of-upper-extremity-injury-penetrating-injuries-caused-by-blunt-edged-items
#4
Hakan Şirinoğlu, Furkan Certel, Nebil Yeşïloğlu, Gökhan Temïz, Kübra Ece Kalafatlar, Murat Sarici, Özhan Çelebïler
BACKGROUND: Penetrating upper extremity injury is a common encountered cause of significant loss of labor force and it is generally caused by sharp items. This article presents five rare cases of penetrating hand and forearm injury caused by blunt-edged items in conjunction with a detailed discussion of the mechanism and management of the injury. METHODS: Five patients with a mean age of 37.6 were treated for upper extremity trauma caused by "blunt-edged items" such as corrugated iron fence, garden wires, iron stick or iron safety fence between 2009 to 2014...
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28203585/can-grafts-provide-superior-tendon-healing-and-clinical-outcomes-after-rotator-cuff-repairs-a-meta-analysis
#5
Yohei Ono, Diego Alejandro Dávalos Herrera, Jarret M Woodmass, Richard S Boorman, Gail M Thornton, Ian K Y Lo
BACKGROUND: Arthroscopic repair of large to massive rotator cuff tears commonly retear. To improve healing rates, a number of different approaches have been utilized, including the use of grafts, which may enhance the biomechanical and biologic aspects of the repair construct. However, the outcomes after the use of grafts are diverse. PURPOSE: To systematically review the literature for large to massive rotator cuff tears to determine whether the use of grafts generally provides superior tendon healing and clinical outcomes to the repairs without grafts...
December 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28197895/follow-up-of-surgical-and-minimally-invasive-treatment-of-achilles-tendon-pathology-a-brief-diagnostic-imaging-review
#6
REVIEW
A Barile, F Bruno, S Mariani, F Arrigoni, L Brunese, M Zappia, A Splendiani, E Di Cesare, C Masciocchi
The follow-up of an operated tendon is primarily clinical, although clinical examination may not be sufficient in the presence of certain complications. The imaging techniques are of great value not only in the diagnosis of tendon pathologies, but also as an adjunct to clinical evaluation. This is particularly true in the follow-up of patients submitted to surgical tendon reconstruction, by monitoring morphological effects of different interventions and evaluating tendon healing processes. Interpretation of imaging findings requires knowledge of the imaging appearance of the operated tendon during the healing phase, to distinguish between normal postsurgical changes and real pathology, as well as knowledge of surgical technique, postoperative course (including type of prescribed therapy) and possible postoperative complications...
February 14, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28195745/anatomic-and-biomechanical-comparison-of-the-classic-and-congruent-arc-techniques-of-the-latarjet-procedure
#7
Scott R Montgomery, J Christoph Katthagen, Jacob D Mikula, Daniel Cole Marchetti, Dimitri S Tahal, Grant J Dornan, Kimi D Dahl, Alex W Brady, Travis Lee Turnbull, Peter J Millett
BACKGROUND: The Latarjet procedure is commonly performed using either the classic or the congruent-arc technique. Each technique has potential clinical advantages and disadvantages. However, data on the anatomic and biomechanical effects, benefits, and limitations of each technique are limited. Hypothesis/Purpose: To compare the anatomy and biomechanical fixation strength (failure load) between the 2 techniques. It was hypothesized that the classic technique would have superior initial fixation when compared with the congruent-arc technique and that this would be affected by sex and coracoid size...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28188545/a-review-of-mallet-finger-and-jersey-finger-injuries-in-the-athlete
#8
REVIEW
Abdo Bachoura, Alex J Ferikes, John D Lubahn
PURPOSE OF REVIEW: The purposes of this review are to discuss the diagnosis and management of mallet and jersey finger injuries in athletes and to highlight how treatment impacts return to play. RECENT FINDINGS: Mallet finger: although numerous non-operative and operative techniques have been described, there continues to be little consensus regarding the optimal procedure. Jersey finger: ultrasound appears to be a cost-effective imaging modality that may be useful for preoperative planning...
February 10, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28165760/comparison-of-acl-strain-in-the-mcl-deficient-and-mcl-reconstructed-knee-during-simulated-landing-in-a-cadaveric-model
#9
Eric J Mancini, Robert Kohen, Amanda O Esquivel, Allison M Cracchiolo, Stephen Edward Lemos
BACKGROUND: Noncontact anterior cruciate ligament (ACL) injury after valgus landing has been reported and studied biomechanically. However, the role of the medial collateral ligament (MCL) in dissipating these forces has not been fully elucidated. Purpose/Hypothesis: The purpose of this study was to investigate the role that the MCL plays in ACL strain during simulated landing. The hypothesis was that ACL strain would increase significantly in MCL-incompetent knees compared with the native knee and that reconstructing the MCL would return the values to those of the intact knee...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28162917/influence-of-preoperative-musculotendinous-junction-position-on-rotator-cuff-healing-after-double-row-repair
#10
Robert Z Tashjian, Gregory A Erickson, Richard J Robins, Yue Zhang, Robert T Burks, Patrick E Greis
PURPOSE: The primary purpose of this study was to determine the effect of the preoperative position of the musculotendinous junction (MTJ) on rotator cuff healing after double-row arthroscopic rotator cuff repair. A secondary purpose was to evaluate how tendon length and MTJ position change when the rotator cuff heals. METHODS: Preoperative and postoperative magnetic resonance imaging (MRI) scans of 42 patients undergoing arthroscopic double-row rotator cuff repair were reviewed...
February 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28162888/the-effectiveness-of-demineralized-cortical-bone-matrix-in-a-chronic-rotator-cuff-tear-model
#11
Tanujan Thangarajah, Frederick Henshaw, Anita Sanghani-Kerai, Simon M Lambert, Gordon W Blunn, Catherine J Pendegrass
BACKGROUND: The purpose of this study was to assess the effect of demineralized bone matrix (DBM) on rotator cuff tendon-bone healing. The hypothesis was that compared with a commercially available dermal matrix scaffold, DBM would result in a higher bone mineral density and regenerate a morphologically superior enthesis in a rat model of chronic rotator cuff degeneration. METHODS: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28155051/a-review-on-animal-models-and-treatments-for-the-reconstruction-of-achilles-and-flexor-tendons
#12
Marta Bottagisio, Arianna B Lovati
Tendon is a connective tissue mainly composed of collagen fibers with peculiar mechanical properties essential to functional movements. The increasing incidence of tendon traumatic injuries and ruptures-associated or not with the loss of tissue-falls on the growing interest in the field of tissue engineering and regenerative medicine. The use of animal models is mandatory to deepen the knowledge of the tendon healing response to severe damages or acute transections. Thus, the selection of preclinical models is crucial to ensure a successful translation of effective and safe innovative treatments to the clinical practice...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28149742/endoscopic-calcaneoplasty-and-achilles-tendoscopy-with-the-patient-in-supine-position
#13
Tun Hing Lui
Insertional and non-insertional Achilles tendinopathy is usually treated conservatively. Surgery is indicated if conservative treatment fails to relieve the pain. Endoscopic surgery has the advantages of less morbidity, a shorter operating time, reduced postoperative pain, and a lower rate of wound and soft-tissue healing problems. Patients will have a short recovery time and quickly resume work and sports because of less soft-tissue disruption. Moreover, the pathology can be better differentiated and precisely treated...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28149729/arthroscopic-rotator-cuff-repair-double-row-transosseous-equivalent-suture-bridge-technique
#14
Mina Abdelshahed, Siddharth A Mahure, Daniel J Kaplan, Brent Mollon, Joseph D Zuckerman, Young W Kwon, Andrew S Rokito
Following a failed course of conservative management, arthroscopic rotator cuff repair (ARCR) has become the gold standard treatment for patients presenting with symptomatic rotator cuff (RC) tears. Traditionally, the single-row repair technique was used. Although most patients enjoy good to excellent clinical outcomes, structural healing to bone remains problematic. As a result, orthopaedic surgeons have sought to improve outcomes with various technological and technical advancements. One such possible advancement is the double-row technique...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28149724/endoscopic-accessory-navicular-synchondrosis-fusion
#15
Tun Hing Lui
The accessory navicular bone is one of the most common accessory ossicles of the foot. Fewer than 1% of accessory navicular bones are symptomatic, and most of these are type II accessory navicular bones. A separation of the synchondrosis is considered one of the main causes of pain. After an injury to the synchondrosis has resulted in a chondro-osseous disruption, the combined forces of tension and shear from the posterior tibial tendon and the foot aggravate the injury and prevent it from healing. Fusion of the synchondrosis is a logical surgical treatment option if the pain is recalcitrant to conservative measures...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28149255/treatment-of-an-acute-deep-hand-burn-in-a-lowincome-country-with-no-available-microsurgery-a-case-report
#16
K S Amouzou, A El Harti, T E Kouevi-Koko, A Abalo, A Dossim
Deep hand burns usually lead to joint and tendon exposure. A simple skin graft is insufficient to achieve healing. Soft tissue reconstruction represents a surgical challenge that ranges from the simplest to the most complex flaps. In some areas, microsurgery is not technically possible. Choice is then limited to pedicled distant flaps such as the abdominal wall flap-graft. We report a case of an acute burned hand with exposure of metacarpophalangeal joints from the second to the fourth radius as well as proximal inter phalangeal joints from the second to the fifth radius and extensor tendons, treated in the burns and wound care unit of the Sylvanus Olympio Teaching Hospital in Lomé...
September 30, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28145809/quantitative-us-elastography-can-be-used-to-quantify-mechanical-and-histologic-tendon-healing-in-a-rabbit-model-of-achilles-tendon-transection
#17
Yohei Yamamoto, Satoshi Yamaguchi, Takahisa Sasho, Taisuke Fukawa, Yorikazu Akatsu, Ryuichiro Akagi, Tadashi Yamaguchi, Kenji Takahashi, Kengo Nagashima, Kazuhisa Takahashi
Purpose To determine the time-dependent change in strain ratios (SRs) at the healing site of an Achilles tendon rupture in a rabbit model of tendon transection and to assess the correlation between SRs and the mechanical and histologic properties of the healing tissue. Materials and Methods Experimental methods were approved by the institutional animal care and use committee. The Achilles tendons of 24 New Zealand white rabbits (48 limbs) were surgically transected. The SRs of Achilles tendons were calculated by using compression-based quantitative ultrasonographic elastography measurements obtained 2, 4, 8, and 12 weeks after transection...
January 31, 2017: Radiology
https://www.readbyqxmd.com/read/28144608/the-current-perspectives-of-stem-cell-therapy-in-orthopedic-surgery
#18
REVIEW
Serkan Akpancar, Oner Tatar, Hasan Turgut, Faruk Akyildiz, Safak Ekinci
CONTEXT: Musculoskeletal injuries may be painful, troublesome, life limiting and also one of the global health problems. There has been considerable amount of interest during the past two decades to stem cells and tissue engineering techniques in orthopedic surgery, especially to manage special and compulsive injuries within the musculoskeletal system. EVIDENCE ACQUISITION: The aim of this study was to present a literature review regarding the most recent progress in stem cell procedures and current indications in orthopedics clinical care practice...
December 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/28137443/extra-articular-subcutaneous-inverted-king-post-truss-ligament-reconstruction-for-severe-swan-neck-deformity-snapping-finger
#19
X de Soras, P de Mourgues, P Pradel, J-P Urien, E Beaudoin
A swan neck deformity (SND) can be well tolerated for a long time, until the appearance of a disabling "snapping finger". In its most advanced condition, the other hand is needed to initiate finger flexion. We propose a technique of extra-articular, subcutaneous ligament reconstruction with an "inverted king post-truss" configuration use in roofs and to reinforce railway bridges. An artificial ligament (MaxBraid™ polyethylene surgical suture, 5 metric, Biomet) makes a figure of eight between transosseous tunnels in the proximal and middle phalanges, crossing over top of the A3 pulley...
February 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28132919/tgf-%C3%AE-1-activation-in-human-hamstring-cells-through-growth-factor-binding-peptides-on-polycaprolactone-surfaces
#20
J Crispim, H A M Fernandes, S C Fu, Y W Lee, P Jonkheijm, D B F Saris
: The administration of soluble growth factors (GFs) to injured tendons and ligaments (T/L) is known to promote and enhance the healing process. However, the administration of GFs is a complex, expensive and heavily-regulated process and only achieved by employing supraphysiological GF concentrations. In addition, for proper healing, specific and spatial immobilization of the GFs (s) is critical. We hypothesized that biomaterials functionalized with GFs-binding peptides can be employed to capture endogenous GFs in a spatially-controlled manner, thus overcoming the need for the exogenous administration of supraphysiological doses of GFs...
January 26, 2017: Acta Biomaterialia
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