keyword
MENU ▼
Read by QxMD icon Read
search

Schizophrenia hallucination

keyword
https://www.readbyqxmd.com/read/29453445/alterations-in-interhemispheric-gamma-band-connectivity-are-related-to-the-emergence-of-auditory-verbal-hallucinations-in-healthy-subjects-during-nmda-receptor-blockade
#1
Thiebes Stephanie, Steinmann Saskia, Curic Stjepan, Polomac Nenad, Andreou Christina, Eichler Iris-Carola, Eichler Lars, Zöllner Christian, Gallinat Jürgen, Leicht Gregor, Mulert Christoph
Auditory verbal hallucinations (AVH) are a common positive symptom of schizophrenia. Excitatory-to-inhibitory (E/I) imbalance related to disturbed N-methyl-D-aspartate receptor (NMDAR) functioning has been suggested as a possible mechanism underlying altered connectivity and AVH in schizophrenia. The current study examined the effects of ketamine, a NMDAR antagonist, on glutamate-related mechanisms underlying interhemispheric gamma-band connectivity, conscious auditory perception during dichotic listening (DL), and the emergence of auditory verbal distortions and hallucinations (AVD/AVH) in healthy volunteers...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29453145/demographic-and-clinical-characteristics-associated-with-a-history-of-bizarre-delusions-in-a-cross-diagnostic-sample-of-individuals-with-psychotic-disorders
#2
Cagri Yuksel, Seheryeli Yilmaz, Ariana Nesbit, Gresa Carkaxhiu, Caitlin Ravichandran, Paola Salvatore, Samira Pingali, Bruce Cohen, Dost Ongur
Bizarre delusions (BizD) are not specific to schizophrenia (SZ) and can be found in other psychotic disorders. However, to date, there are no studies investigating socio-demographic and clinical characteristics associated with BizD across the psychosis spectrum. In this study 819 subjects with a diagnosis of SZ (n = 250), schizoaffective disorder (SZA) (n = 228) and bipolar I disorder (BD) (n = 341) were included. Patients with history of BizD and with no BizD were compared with respect to socidemographic and clinical variables, and predictors of BizD were explored...
February 9, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29444726/resting-state-thalamic-dysconnectivity-in-schizophrenia-and-relationships-with-symptoms
#3
J Ferri, J M Ford, B J Roach, J A Turner, T G van Erp, J Voyvodic, A Preda, A Belger, J Bustillo, D O'Leary, B A Mueller, K O Lim, S C McEwen, V D Calhoun, M Diaz, G Glover, D Greve, C G Wible, J G Vaidya, S G Potkin, D H Mathalon
BACKGROUND: Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cerebellum and prefrontal cortex as well as thalamic hyperconnectivity with sensory cortical regions in SZ patients compared with healthy comparison participants (HCs). However, fundamental questions remain regarding the clinical significance of these connectivity abnormalities...
February 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29444349/suicidal-ideation-in-first-episode-psychosis-fep-examination-of-symptoms-of-depression-and-psychosis-among-individuals-in-an-early-phase-of-treatment
#4
Lindsay A Bornheimer
First-episode psychosis (FEP) is a particularly high-risk period for suicide, in which risk elevates by 60% within a first year of treatment as compared to later stages of illness. To date, much of the literature has focused on individuals with a longer duration of psychosis; thus, there is an urgency for research to examine suicide risk among individuals in FEP in the beginning stage of treatment. This study aimed to identify the relationships between demographic characteristics, symptoms of depression, psychosis (particularly positive symptoms of psychosis), and suicidal ideation among individuals in FEP...
February 14, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29441665/cortical-thickness-abnormalities-in-bipolar-disorder-patients-with-a-lifetime-history-of-auditory-hallucinations
#5
Lynn Mørch-Johnsen, Stener Nerland, Kjetil N Jørgensen, Kåre Osnes, Cecilie B Hartberg, Ole A Andreassen, Ingrid Melle, Ragnar Nesvåg, Ingrid Agartz
OBJECTIVES: We aimed to investigate morphometric correlates of auditory hallucinations in bipolar disorder (BD) by comparing cortical thickness and cortical surface area in bipolar disorder patients with (BD+) and without (BD-) a lifetime history of auditory hallucinations. Based on previous findings in schizophrenia patients, we hypothesized that the cortex would be thinner in the auditory cortex in BD+ compared to BD-. METHODS: Bipolar disorder spectrum (n = 157) patients and healthy controls (n = 279) underwent 1...
February 13, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29436999/pharmacoinformatics-and-molecular-docking-studies-reveal-potential-novel-compounds-against-schizophrenia-by-target-syn-ii
#6
Rana Adnan Tahir, Sheikh Arslan Sehgal
BACKGROUND: Synapsin II regulates neurotransmitter release from mature nerve terminals and plays important role in the formation of new nerve terminals. The associations of SYN II are identified in various studies that are linked to the onset of Schizophrenia. Schizophrenia is characterized by abnormal behavior like obsession, dampening of emotions and auditory hallucination. METHODS: The bioinformatics approaches were utilized for structural modeling and docking analyses of SYN II followed by pharmacophore generation to identify potent inhibitors...
February 12, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29430009/real-time-fmri-neurofeedback-to-down-regulate-superior-temporal-gyrus-activity-in-patients-with-schizophrenia-and-auditory-hallucinations-a-proof-of-concept-study
#7
Natasza D Orlov, Vincent Giampietro, Owen O'Daly, Sheut-Ling Lam, Gareth J Barker, Katya Rubia, Philip McGuire, Sukhwinder S Shergill, Paul Allen
Neurocognitive models and previous neuroimaging work posit that auditory verbal hallucinations (AVH) arise due to increased activity in speech-sensitive regions of the left posterior superior temporal gyrus (STG). Here, we examined if patients with schizophrenia (SCZ) and AVH could be trained to down-regulate STG activity using real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF). We also examined the effects of rtfMRI-NF training on functional connectivity between the STG and other speech and language regions...
February 12, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29413808/efficacy-of-non-invasive-brain-stimulation-on-the-symptom-dimensions-of-schizophrenia-a-meta-analysis-of-randomized-controlled-trials
#8
Nigel I Kennedy, Won Hee Lee, Sophia Frangou
BACKGROUND: Transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) have shown promise in the treatment of schizophrenia. OBJECTIVE: To quantify the efficacy of double-blind randomized controlled trials (RCT) of tDCS and rTMS for the positive and negative symptoms of schizophrenia and identify significant moderators relating to patient-related features and stimulation parameters. METHODS: Systemic review and meta-analyses of the relevant literature published until February 1st, 2017 to assess treatment efficacy and quantify the contribution of potential moderator variables...
January 27, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29409548/a-clinimetric-analysis-of-a-bprs-6-scale-for-schizophrenia-severity
#9
Per Bech, Stephen F Austin, Nina Timmerby, Thomas A Ban, Stine Bjerrum Møller
OBJECTIVE: A restricted Brief Psychiatric Rating Scale (BPRS-6) with the six schizophrenia specific items from the Positive and Negative Syndrome Scale (PANSS) has been investigated. These six items from the PANSS have recently been found to have both clinical validity and 'unidimensionality' in measuring the severity of schizophrenic states. The primary objective of this study was to evaluate the clinical validity of the BPRS-6. The secondary objective was to evaluate the 'unidimensionality' of the BPRS-6 by an 'item response theory' model...
February 7, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29398218/a-perceptual-inference-mechanism-for-hallucinations-linked-to-striatal-dopamine
#10
Clifford M Cassidy, Peter D Balsam, Jodi J Weinstein, Rachel J Rosengard, Mark Slifstein, Nathaniel D Daw, Anissa Abi-Dargham, Guillermo Horga
Hallucinations, a cardinal feature of psychotic disorders such as schizophrenia, are known to depend on excessive striatal dopamine. However, an underlying cognitive mechanism linking dopamine dysregulation and the experience of hallucinatory percepts remains elusive. Bayesian models explain perception as an optimal combination of prior expectations and new sensory evidence, where perceptual distortions such as illusions and hallucinations may occur if prior expectations are afforded excessive weight. Such excessive weight of prior expectations, in turn, could stem from a gain-control process controlled by neuromodulators such as dopamine...
February 1, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29395749/reduced-white-matter-connectivity-associated-with-auditory-verbal-hallucinations-in-first-episode-and-chronic-schizophrenia-a-diffusion-tensor-imaging-study
#11
Xiaoling Zhang, Jie Gao, Feng Zhu, Wei Wang, Yajuan Fan, Qingyan Ma, Xiancang Ma, Jian Yang
This study aims to explore whether auditory verbal hallucinations (AVH) in schizophrenia are associated with the white matter abnormalities in tracts connecting language, auditory and memory/limbic networks in first-episode and chronic schizophrenia patients. 21 first-episode (FE-AVH) and 12 chronic (chronic-AVH group) patients who suffered from auditory verbal hallucinations and 26 healthy controls (HC group) were enrolled. Diffusion tensor imaging with tract-based spatial statistics was performed to assess the white matter changes between the two patient groups and HC group...
January 25, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29384891/familial-risk-for-psychiatric-disorders-in-military-veterans-who-have-post-traumatic-stress-disorder-with-psychosis-a-retrospective-electronic-record-review
#12
Aengus ÓConghaile, Diane L Smedberg, Ah L Shin, Lynn E DeLisi
AIMS/OBJECTIVES/BACKGROUND: Post-traumatic stress disorder (PTSD) is a leading cause of morbidity among military veterans, with up to one-in-five individuals with PTSD also having psychotic symptoms. The current study was designed to determine the association between a known family history of psychiatric illness and risk of developing psychosis in patients with PTSD. METHODS: Retrospective medical record review was performed on a cohort study of 414 consecutive individuals admitted to the Veteran Administration in 2014 with a diagnosis of military-related PTSD, but without a prior diagnosis of a psychotic disorder...
January 30, 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29373050/diagnostic-accuracy-of-the-casi-4r-psychosis-subscale-for-children-evaluated-in-pediatric-outpatient-clinics
#13
Sabeen H Rizvi, Stephanie Salcedo, Eric A Youngstrom, Lindsey K Freeman, Kenneth D Gadow, Mary A Fristad, Boris Birmaher, Robert A Kowatch, Sarah M Horwitz, Thomas W Frazier, L Eugene Arnold, H Gerry Taylor, Robert L Findling
Diagnostic accuracy of the Diagnostic and Statistical Manual of Mental Disorders-oriented Child and Adolescent Symptom Inventory (CASI-4R) Psychotic Symptoms scale was tested using receiver operating characteristic analyses to identify clinically significant psychotic symptoms. Participants were new outpatients (N = 700), ages 6.0 to 12.9 years (M = 9.7, SD = 1.8) at 9 child outpatient mental health clinics, who participated in the Longitudinal Assessment of Manic Symptoms (LAMS) Study baseline assessment...
January 26, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29356010/a-life-in-academia-my-career-in-brief
#14
Kenneth Hugdahl
In this article I have summarized some of the main trends and topics of my research career, spanning a time period of 50 years, from its start as a master student at the Department of Psychology, University of Uppsala, Sweden to seeing the end of a long career, now at the University of Bergen, Norway. This journey has, apart from having been a journey across various disciplines and topics in experimental psychology, psychophysiology and neuropsychology, functional neuroimaging and cognitive neuroscience, also been a social class journey for me personally...
February 2018: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29356009/hallucinations-neuroplasticity-and-prediction-errors-in-schizophrenia
#15
Amanda McCleery, Jonathan K Wynn, Michael F Green
Auditory hallucinations, a hallmark symptom of psychosis, are experienced by most people with a diagnosis of schizophrenia at some point in their illness. Auditory hallucinations can be understood as a failure in predictive coding, whereby abnormalities in sensory/perceptual processing combine with biased cognitive processes to result in a dampening of normal prediction error signaling. In this paper, we used a roving mismatch negativity (MMN) paradigm to optimize evaluation of prediction error signaling and short-term neuroplasticity in 30 people with schizophrenia (n = 16 with and n = 14 without recent auditory hallucinations) and 20 healthy comparison participants...
February 2018: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29350251/pyramidal-cell-selective-glun1-knockout-causes-impairments-in-salience-attribution-and-related-eeg-activity
#16
Alexandra D Forrest, Jakyung Bang, Robert E Featherstone, Jonathan H Bloom, Matthew S Luminais, Rebecca V Zhang, Christopher R Gajewski, Mary F McMullen, Yuling Liang, Steven J Siegel
Schizophrenia is a disabling psychiatric disease characterized by symptoms including hallucinations, delusions, social withdrawal, loss of pleasure, and inappropriate affect. Although schizophrenia is marked by dysfunction in dopaminergic and glutamatergic signaling, it is not presently clear how these dysfunctions give rise to symptoms. The aberrant salience hypothesis of schizophrenia argues that abnormal attribution of motivational salience to stimuli is one of the main contributors to both positive and negative symptoms of schizophrenia...
January 19, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29344344/acetylcholinesterase-inhibitors-in-treatment-resistant-psychotic-depression
#17
Chris Smart, Hamish McAllister-Williams, David Andrew Cousins
Dopamine receptor antagonists can be effective in psychotic depression but response is not assured. Visual hallucinations may arise from a dysregulation of brain cholinergic systems and acetylcholinesterase inhibitors (AChEIs) can treat such hallucinations in dementia with Lewy bodies (DLB). AChEIs have been used in schizophrenia with some success but their efficacy and tolerability in psychotic depression is unclear. This striking case illustrates AChEIs specifically targeting multimodal hallucinations in treatment-resistant depression...
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29343559/a-genetic-locus-for-paranoia
#18
Bernard Crespi, Silven Read, Iiro Salminen, Peter Hurd
The psychological effects of brain-expressed imprinted genes in humans are virtually unknown. Prader-Willi syndrome (PWS) is a neurogenetic condition mediated by genomic imprinting, which involves high rates of psychosis characterized by hallucinations and paranoia, as well as autism. Altered expression of two brain-expressed imprinted genes, MAGEL2 and NDN, mediates a suite of PWS-related phenotypes, including behaviour, in mice. We phenotyped a large population of typical individuals for schizophrenia-spectrum and autism-spectrum traits, and genotyped them for the single-nucleotide polymorphism rs850807, which is putatively functional and linked with MAGEL2 and NDN Genetic variation in rs850807 was strongly and exclusively associated with the ideas of reference subscale of the schizophrenia spectrum, which is best typified as paranoia...
January 2018: Biology Letters
https://www.readbyqxmd.com/read/29341341/prediction-of-activation-patterns-preceding-hallucinations-in-patients-with-schizophrenia-using-machine-learning-with-structured-sparsity
#19
Amicie de Pierrefeu, Thomas Fovet, Fouad Hadj-Selem, Tommy Löfstedt, Philippe Ciuciu, Stephanie Lefebvre, Pierre Thomas, Renaud Lopes, Renaud Jardri, Edouard Duchesnay
Despite significant progress in the field, the detection of fMRI signal changes during hallucinatory events remains difficult and time-consuming. This article first proposes a machine-learning algorithm to automatically identify resting-state fMRI periods that precede hallucinations versus periods that do not. When applied to whole-brain fMRI data, state-of-the-art classification methods, such as support vector machines (SVM), yield dense solutions that are difficult to interpret. We proposed to extend the existing sparse classification methods by taking the spatial structure of brain images into account with structured sparsity using the total variation penalty...
January 16, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29332009/poststroke-psychosis-a-systematic-review
#20
REVIEW
Helle Stangeland, Vasiliki Orgeta, Vaughan Bell
A preregistered systematic review of poststroke psychosis examining clinical characteristics, prevalence, diagnostic procedures, lesion location, treatments, risk factors and outcome. Neuropsychiatric outcomes following stroke are common and severely impact quality of life. No previous reviews have focused on poststroke psychosis despite clear clinical need. CINAHL, MEDLINE and PsychINFO were searched for studies on poststroke psychosis published between 1975 and 2016. Reviewers independently selected studies for inclusion, extracted data and rated study quality...
January 13, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
keyword
keyword
89031
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"