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Schizophrenia hallucination

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https://www.readbyqxmd.com/read/29684224/mismatch-negativity-and-cortical-thickness-in-patients-with-schizophrenia-and-bipolar-disorder
#1
Sungkean Kim, Hyeonjin Jeon, Kuk-In Jang, Yong-Wook Kim, Chang-Hwan Im, Seung-Hwan Lee
Introduction: Mismatch negativity (MMN) is a measure of automatic neurophysiological brain processes for detecting unexpected sensory stimuli. This study investigated MMN reduction in patients with schizophrenia and bipolar disorder and examined whether cortical thickness is associated with MMN, for exploratory purposes. Methods: Electroencephalograms were recorded in 38 patients with schizophrenia, 37 patients with bipolar disorder, and 32 healthy controls (HCs) performing a passive auditory oddball paradigm...
April 19, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29680513/the-relationship-between-illicit-amphetamine-use-and-psychiatric-symptom-profiles-in-schizophrenia-and-affective-psychoses
#2
Alexandra Voce, Rebecca McKetin, Richard Burns, David Castle, Bianca Calabria
This study examines whether illicit amphetamine use is associated with differences in the prevalence of specific psychiatric symptoms in a community sample of individuals diagnosed with schizophrenia or affective psychotic disorders. Data was drawn from the Australian Survey of High Impact Psychosis. The Diagnostic Interview for Psychosis was used to measure substance use and psychiatric symptoms. Participants had used amphetamine within their lifetime and had an ICD-10 diagnosis of schizophrenia (n = 347) or an affective psychotic disorder (n = 289)...
April 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29672108/a-greater-tendency-for-representation-mediated-learning-in-a-ketamine-mouse-model-of-schizophrenia
#3
Ming Teng Koh, Paige S Ahrens, Michela Gallagher
Representation mediated learning is a behavioral paradigm that could be used to potentially capture psychotic symptoms including hallucinations and delusions in schizophrenia. In studies of mediated learning, representations of prior experience can enter into current associations. Using a ketamine model of schizophrenia, we investigated whether mice exposed to ketamine during late adolescence subsequently showed an increased tendency to use a representation of a prior gustatory experience to form associations in learning...
April 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29660081/data-driven-analysis-of-functional-connectivity-reveals-a-potential-auditory-verbal-hallucination-network
#4
Dustin Scheinost, Fuyuze Tokoglu, Michelle Hampson, Ralph Hoffman, R Todd Constable
Schizophrenia is a severe global health problem, with over half of such patients experiencing auditory verbal hallucinations (AVHs). A better understanding of the neural correlates differentiating patients experiencing AVHs from patients not experiencing AVHs and healthy controls may identify targets that lead to better treatment strategies for AVHs. Employing 2 data-driven, voxel-based measure of functional connectivity, we studied 46 patients with schizophrenia or schizoaffective disorder (28 experiencing AVHs and 18 not experiencing AVHs)...
April 5, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29605187/antipsychotic-drugs-versus-cognitive-behavioural-therapy-versus-a-combination-of-both-in-people-with-psychosis-a-randomised-controlled-pilot-and-feasibility-study
#5
Anthony P Morrison, Heather Law, Lucy Carter, Rachel Sellers, Richard Emsley, Melissa Pyle, Paul French, David Shiers, Alison R Yung, Elizabeth K Murphy, Natasha Holden, Ann Steele, Samantha E Bowe, Jasper Palmier-Claus, Victoria Brooks, Rory Byrne, Linda Davies, Peter M Haddad
BACKGROUND: Little evidence is available for head-to-head comparisons of psychosocial interventions and pharmacological interventions in psychosis. We aimed to establish whether a randomised controlled trial of cognitive behavioural therapy (CBT) versus antipsychotic drugs versus a combination of both would be feasible in people with psychosis. METHODS: We did a single-site, single-blind pilot randomised controlled trial in people with psychosis who used services in National Health Service trusts across Greater Manchester, UK...
March 28, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29603866/genome-wide-analysis-of-adolescent-psychotic-like-experiences-shows-genetic-overlap-with-psychiatric-disorders
#6
Oliver Pain, Frank Dudbridge, Alastair G Cardno, Daniel Freeman, Yi Lu, Sebastian Lundstrom, Paul Lichtenstein, Angelica Ronald
This study aimed to test for overlap in genetic influences between psychotic-like experience traits shown by adolescents in the community, and clinically-recognized psychiatric disorders in adulthood, specifically schizophrenia, bipolar disorder, and major depression. The full spectra of psychotic-like experience domains, both in terms of their severity and type (positive, cognitive, and negative), were assessed using self- and parent-ratings in three European community samples aged 15-19 years (Final N incl...
March 31, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29593589/comorbid-diagnosis-of-psychotic-disorders-in-borderline-personality-disorder-prevalence-and-influence-on-outcome
#7
C W Slotema, Jan D Blom, Marieke B A Niemantsverdriet, Mathijs Deen, Iris E C Sommer
Background: A diagnosis of psychotic disorder is traditionally considered incompatible with borderline personality disorder (BPD), even though patients sometimes fulfill the diagnostic criteria for both disorders. How often this happens is barely known, as is the influence of comorbid psychotic disorders on the outcome of BPD. Since studies on isolated auditory verbal hallucinations in patients with BPD indicate that these perceptual symptoms have severe consequences and are associated with suicidal behavior and hospitalization, patients with comorbid psychotic disorders are unlikely to fare better...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29593580/self-reported-visual-perceptual-abnormalities-are-strongly-associated-with-core-clinical-features-in-psychotic-disorders
#8
Brian P Keane, Lisa N Cruz, Danielle Paterno, Steven M Silverstein
Background: Past studies using the Bonn Scale for the Assessment of Basic Symptoms (hereafter, Bonn Scale) have shown that self-reported perceptual/cognitive disturbances reveal which persons have or will soon develop schizophrenia. Here, we focused specifically on the clinical value of self-reported visual perceptual abnormalities (VPAs) since they are underexplored and have been associated with suicidal ideation, negative symptoms, and objective visual dysfunction. Method: Using the 17 Bonn Scale vision items, we cross-sectionally investigated lifetime occurrence of VPAs in 21 first-episode psychosis and 22 chronic schizophrenia/schizoaffective disorder (SZ/SA) patients...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29589219/risk-factors-for-suicide-in-older-inpatient-veterans-with-schizophrenia
#9
Candace Fraser, James Luther, John Kasckow
Patients with schizophrenia have an elevated risk of suicidal behavior. We explored whether there were age differences in inpatients with schizophrenia admitted for suicidal behavior. We compared demographic/clinical characteristics of 76 inpatients aged > 59 to those < 60. All patients had a score greater > 0 on items 4 (active suicidality) and/or 5 (passive suicidality) on the Beck Scale for Suicidal Ideation for inclusion. There were no significant group differences with respect to race, education, depressive symptoms or negative symptoms...
March 27, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29580740/negative-voice-content-as-a-full-mediator-of-a-relation-between-childhood-adversity-and-distress-ensuing-from-hearing-voices
#10
Cherise Rosen, Simon McCarthy-Jones, Nev Jones, Kayla A Chase, Rajiv P Sharma
A key predictor of whether or not an individual who hears voices (auditory verbal hallucinations; AVH) meets criteria for a psychiatric diagnosis is the level of negative content of the voices (e.g., threats, criticism, abuse). Yet the factors that contribute to negative voice-content are still not well understood. This study aimed to test the hypotheses that levels of childhood adversity would predict levels of negative voice-content, and that negative voice-content would partially mediate a relation between childhood adversity and voice-related distress...
March 23, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29571753/disrupted-network-cross-talk-hippocampal-dysfunction-and-hallucinations-in-schizophrenia
#11
Stephanie M Hare, Alicia S Law, Judith M Ford, Daniel H Mathalon, Aral Ahmadi, Eswar Damaraju, Juan Bustillo, Aysenil Belger, Hyo Jong Lee, Bryon A Mueller, Kelvin O Lim, Gregory G Brown, Adrian Preda, Theo G M van Erp, Steven G Potkin, Vince D Calhoun, Jessica A Turner
Hallucinations characterize schizophrenia, with approximately 59% of patients reporting auditory hallucinations and 27% reporting visual hallucinations. Prior neuroimaging studies suggest that hallucinations are linked to disrupted communication across distributed (sensory, salience-monitoring and subcortical) networks. Yet, our understanding of the neurophysiological mechanisms that underlie auditory and visual hallucinations in schizophrenia remains limited. This study integrates two resting-state functional magnetic resonance imaging (fMRI) analysis methods - amplitudes of low-frequency fluctuations (ALFF) and functional network connectivity (FNC) - to explore the hypotheses that (1) abnormal FNC between salience and sensory (visual/auditory) networks underlies hallucinations in schizophrenia, and (2) disrupted hippocampal oscillations (as measured by hippocampal ALFF) beget changes in FNC linked to hallucinations...
March 20, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29569473/neurofeedback-based-enhancement-of-single-trial-auditory-evoked-potentials-treatment-of-auditory-verbal-hallucinations-in-schizophrenia
#12
Kathryn Rieger, Marie-Helene Rarra, Laura Diaz Hernandez, Daniela Hubl, Thomas Koenig
Auditory verbal hallucinations depend on a broad neurobiological network ranging from the auditory system to language as well as memory-related processes. As part of this, the auditory N100 event-related potential (ERP) component is attenuated in patients with schizophrenia, with stronger attenuation occurring during auditory verbal hallucinations. Changes in the N100 component assumingly reflect disturbed responsiveness of the auditory system toward external stimuli in schizophrenia. With this premise, we investigated the therapeutic utility of neurofeedback training to modulate the auditory-evoked N100 component in patients with schizophrenia and associated auditory verbal hallucinations...
March 1, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29559020/gene-polymorphisms-and-response-to-transcranial-direct-current-stimulation-for-auditory-verbal-hallucinations-in-schizophrenia
#13
Harleen Chhabra, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anushree Bose, Sri Mahavir Agarwal, Vanteemar S Sreeraj, Damodharan Dinakaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
OBJECTIVE: Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia. METHODS: Schizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS...
March 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29556765/diagnostic-efficiency-of-the-cbcl-thought-problems-and-dsm-oriented-psychotic-symptoms-scales-for-pediatric-psychotic-symptoms
#14
Stephanie Salcedo, Sabeen H Rizvi, Lindsey K Freeman, Jennifer K Youngstrom, Robert L Findling, Eric A Youngstrom
We compared the diagnostic efficiency of the Child Behavior Checklist (CBCL) Thought Problems subscale and the rationally derived DSM-oriented psychotic symptoms scale (DOPSS) to identify clinically concerning psychosis in a multi-site sample of youths seeking outpatient mental health services (N = 694). We operationally defined clinically concerning psychosis as the presence of clinically significant hallucinations or delusions, assessed by the Schedule for Affective Disorders and Schizophrenia psychosis items...
March 20, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29533819/randomized-trial-of-transcranial-alternating-current-stimulation-for-treatment-of-auditory-hallucinations-in-schizophrenia
#15
Juliann M Mellin, Sankaraleengam Alagapan, Caroline Lustenberger, Courtney E Lugo, Morgan L Alexander, John H Gilmore, L Fredrik Jarskog, Flavio Fröhlich
BACKGROUND: Approximately 30% of patients with schizophrenia experience auditory hallucinations that are refractory to antipsychotic medications. Here, we evaluated the feasibility and efficacy of transcranial alternating current stimulation (tACS) that we hypothesized would improve auditory hallucination symptoms by enhancing synchronization between the frontal and temporo-parietal areas of the left hemisphere. METHOD: 22 participants were randomized to one of three arms and received twice daily, 20 min sessions of sham, 10 Hz 2 mA peak-to-peak tACS, or 2 mA tDCS over the course of 5 consecutive days...
March 10, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29528896/toward-personalized-treatment-of-hallucinations
#16
Iris E Sommer, Hidde Kleijer, Kenneth Hugdahl
PURPOSE OF REVIEW: Hallucinations are common and often stressful experiences, occurring in all sensory modalities. They frequently complicate many disorders or situations, such as Parkinson's disease, schizophrenia, hearing or vision loss, intoxications and delirium. Although psychoeducation, coping techniques and psychotherapy may be broadly applicable, they do not address a specific underlying brain mechanism. Pharmacotherapy may effectively alleviate hallucinations if the corresponding mechanism is present, whereas in its absence, may only cause harmful side effects...
May 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29528895/use-of-psychotropic-medication-in-women-with-psychotic-disorders-at-menopause-and-beyond
#17
Mary V Seeman, Alexandre González-Rodríguez
PURPOSE OF REVIEW: Drugs have been extensively prescribed for the treatment of psychotic symptoms in schizophrenia and related disorders, as well as for the management of psychotic features in delirium, dementia and affective disorders. The aim of this narrative review is to focus on the recent literature on drug treatment in women with psychosis at the transition to menopause and subsequently. RECENT FINDINGS: The recent literature emphasizes the following points: the efficacy of antipsychotic medication in psychosis is largely confined to the alleviation of delusions and hallucinations; menopause and ageing alter the kinetics and dynamics of drug action; drugs other than antipsychotics are currently being tested to address the cognitive, affective and negative symptoms of psychotic illnesses; menopausal symptoms add to comorbidities and require simultaneous treatment, raising the probability of deleterious drug interactions; antipsychotic drugs have many side effects and contribute to high mortality rates in the older psychosis population...
March 9, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29527474/linked-functional-network-abnormalities-during-intrinsic-and-extrinsic-activity-in-schizophrenia-as-revealed-by-a-data-fusion-approach
#18
Ryu-Ichiro Hashimoto, Takashi Itahashi, Rieko Okada, Sayaka Hasegawa, Masayuki Tani, Nobumasa Kato, Masaru Mimura
Abnormalities in functional brain networks in schizophrenia have been studied by examining intrinsic and extrinsic brain activity under various experimental paradigms. However, the identified patterns of abnormal functional connectivity (FC) vary depending on the adopted paradigms. Thus, it is unclear whether and how these patterns are inter-related. In order to assess relationships between abnormal patterns of FC during intrinsic activity and those during extrinsic activity, we adopted a data-fusion approach and applied partial least square (PLS) analyses to FC datasets from 25 patients with chronic schizophrenia and 25 age- and sex-matched normal controls...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29516640/concordance-of-child-self-reported-psychotic-experiences-with-interview-and-observer-based-psychotic-experiences
#19
Steffie V Gundersen, Robert Goodman, Lars Clemmensen, Martin K Rimvall, Anja Munkholm, Charlotte Ulrikka Rask, Anne Mette Skovgaard, Jim Van Os, Pia Jeppesen
AIM: Valid instruments for the early identification of psychotic experiences (PE) and symptoms in youths are urgently needed for large-scale preventive interventions. A new section of The-Development-and-Well-Being Assessment (DAWBA) measuring child self-reported PE has yet to be validated. The current study aimed to investigate the concurrent validity of DAWBA-based self-reported PE (PE-S) with regard to interview-based measures of PE (PE-I). METHODS: Participants were 1571 (47...
March 8, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29516555/methamphetamine-psychosis-insights-from-the-past
#20
Rebecca McKetin
BACKGROUND AND AIMS: To review early case reports and experimental inductions of amphetamine and methamphetamine psychosis, prior to the prohibition of these drugs, to gain a better understanding of the nature and aetiology of methamphetamine psychosis. METHODS: Papers considered were historical case reports and case series of psychosis relating to the use and misuse of prescription amphetamine, focusing upon papers by Young & Scoville (1938), Connell (1958), and three subsequent experimental studies published in the early 1970s (Griffith 1972, Angrist & Gershon 1970 and Bell 1973), where psychosis was induced in volunteers using high-dose amphetamine and methamphetamine...
March 8, 2018: Addiction
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