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Randomised controlled trail

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https://www.readbyqxmd.com/read/28681715/motor-cortex-trns-improves-pain-affective-and-cognitive-impairment-in-patients-with-fibromyalgia-preliminary-results-of-a-randomised-sham-controlled-trial
#1
Massimiliano Curatolo, Giuseppe La Bianca, Giuseppe Cosentino, Roberta Baschi, Giuseppe Salemi, Rossella Talotta, Marcello Romano, Giovanni Triolo, Marina De Tommaso, Brigida Fierro, Filippo Brighina
OBJECTIVES: Fibromyalgia (FM) is a clinical syndrome characterised by widespread musculoskeletal pain, chronic fatigue, cognitive deficits, and sleep and mood disorders. The effectiveness of most pharmacological treatments is limited, and there is a need for new, effective and well-tolerated therapies. It has recently been shown that transcranial direct-current stimulation (tDCS) of the motor cortex reduces pain, and that tDCS of the dorso-lateral prefrontal cortex (DLPFC) improves anxiety, depression and cognitive impairment in FM patients...
May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28678111/effectiveness-and-safety-of-batroxobin-tranexamic-acid-and-a-combination-in-reduction-of-blood-loss-in-lumbar-spinal-fusion-surgery
#2
Roopa Mn, Ajoy Prasad Shetty, Srikanth Reddy Dumpa, Balavenkat Subarmaniam, Rishi Mugesh Kanna, Rajasekeran Shanmuganathan
STUDY DESIGN: A prospective randomized double blind placebo controlled trail OBJECTIVE.: To evaluate and compare the efficacy and safety of Batroxobin (botropase),Tranexamic acid(TXA) and their combination in reduction of perioperative blood loss in lumbar spine single level fusion surgeries. SUMMARY OF BACKGROUND DATA: Spinal surgeries are associated with significant blood loss leading to perioperative anaemia and increased need for allogenic transfusion. TXA competitively inhibits plasmin and batroxobin converts fibrinogen to fibrin and theoretically their combination is synergistic ...
July 3, 2017: Spine
https://www.readbyqxmd.com/read/28533517/vortioxetine-reduces-bold-signal-during-performance-of-the-n-back-working-memory-task-a-randomised-neuroimaging-trial-in-remitted-depressed-patients-and-healthy-controls
#3
J Smith, M Browning, S Conen, R Smallman, J Buchbjerg, K G Larsen, C K Olsen, S R Christensen, G R Dawson, J F Deakin, P Hawkins, R Morris, G Goodwin, C J Harmer
Cognitive dysfunction is common in depression during both acute episodes and remission. Vortioxetine is a novel multimodal antidepressant that has improved cognitive function including executive function in depressed patients in randomised placebo-controlled clinical trials. However, it is unclear whether vortioxetine is able to target directly the neural circuitry implicated in the cognitive deficits in depression. Remitted depressed (n=48) and healthy volunteers (n=48) were randomised to receive 14 days treatment with 20 mg vortioxetine or placebo in a double-blind design...
May 23, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28511288/a-tele-health-follow-up-strategy-for-tight-control-of-disease-activity-in-rheumatoid-arthritis-results-of-the-non-inferiority-randomised-controlled-trail-the-tera-study
#4
Annette Thurah, Kristian Stengaard-Pedersen, Mette Axelsen, Ulrich Fredberg, Liv M V Schougaard, Niels H I Hjollund, Mogens Pfeiffer-Jensen, Trine B Laurberg, Ulrik Tarp, Kirsten Lomborg, Thomas Maribo
OBJECTIVE: To test the effect of patient-reported outcome (PRO) based tele-health follow-up for tight control of disease activity in patients with rheumatoid arthritis (RA), and the differences between tele-health follow-up performed by rheumatologists or rheumatology nurses. METHODS: A total of 294 patients were randomized (1:1:1) to either PRO-based tele-health follow-up carried out by a nurse (PRO-TN) or a rheumatologist (PRO-TR), or conventional out-patient follow-up by physicians...
May 16, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28467128/cystodistension-is-there-evidence-to-support-its-use-in-current-practice-for-patients-with-overactive-bladder
#5
Aswini Balachandran, Jonathan Duckett
Cystoscopy and cystodistension have been part of common treatment protocols for a variety of bladder conditions for many years. However, the science behind the procedure is not strong and continued use of the operation may not be justified. Much research is old and was not planned or executed with the current rigour demanded by current trial methods. Newer treatments such as intravesical botulinum toxin have been extensively researched and found to be effective. This review article aimed to review the evidence behind the use of cystodistension for overactive bladder (OAB) with the aim of identifying the weaknesses in the current evidence...
May 3, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28401595/assessing-a-cognitive-music-training-for-older-participants-a-randomised-controlled-trial
#6
Michele Biasutti, Anthony Mangiacotti
OBJECTIVES: In a randomised controlled trial, we investigated whether a cognitive training based on rhythm-music and music improvisation exercises had positive effects on executive functions in older participants. METHODS: Thirty-five residents in a guest home with mild-moderate cognitive impairment and healthy ageing were randomly assigned to an experimental group (n = 18) featuring cognitive music training composed of 12 bi-weekly 70-min sessions, and a control group (n = 17) attended 12 bi-weekly 45-min sessions of gymnastic activities offered by the institute...
April 12, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28330458/the-effects-of-an-extensive-exercise-programme-on-the-progression-of-mild-cognitive-impairment-mci-study-protocol-for-a-randomised-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Kate E Devenney, Marit L Sanders, Brian Lawlor, Marcel G M Olde Rikkert, Stefan Schneider
BACKGROUND: Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by increasing cognitive reserve. There is also evidence of structural changes caused by exercise in preventing or delaying the genesis of neurodegeneration. Although initial studies indicate enhanced cognitive performance in patients with mild cognitive impairment (MCI) following an exercise intervention, little is known about the effect of an extensive, controlled and regular exercise regimen on the neuropathology of patients with MCI...
March 22, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28318984/safety-and-efficacy-of-thrombectomy-in-acute-ischaemic-stroke-revascat-1-year-follow-up-of-a-randomised-open-label-trial
#8
RANDOMIZED CONTROLLED TRIAL
Antoni Dávalos, Erik Cobo, Carlos A Molina, Angel Chamorro, M Angeles de Miquel, Luis San Román, Joaquín Serena, Elena López-Cancio, Marc Ribó, Mónica Millán, Xabier Urra, Pere Cardona, Alejandro Tomasello, Carlos Castaño, Jordi Blasco, Lucía Aja, Marta Rubiera, Meritxell Gomis, Arturo Renú, Blanca Lara, Joan Martí-Fàbregas, Brian Jankowitz, Neus Cerdà, Tudor G Jovin
BACKGROUND: The REVASCAT trial and other studies have shown that the neurovascular thrombectomy improves outcomes at 90 days post stroke. However, whether the observed benefit is sustained in the long term remains unknown. We report the results of the prespecified 12-month analysis of the REVASCAT trial. METHODS: Patients with acute ischaemic stroke who could be treated within 8 h of symptom onset were randomly assigned to medical therapy (including intravenous alteplase when eligible) and neurovascular thrombectomy with Solitaire FR or medical therapy alone...
May 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28185899/lurasidone-versus-treatment-as-usual-for-cognitive-impairment-in-euthymic-patients-with-bipolar-i-disorder-a-randomised-open-label-pilot-study
#9
Lakshmi N Yatham, Sylvia Mackala, Jayasree Basivireddy, Sharon Ahn, Nazlin Walji, Chen Hu, Raymond W Lam, Ivan J Torres
BACKGROUND: Cognitive impairment is present in euthymic patients with bipolar disorder and correlates with impairments in everyday functioning. We aimed to examine the efficacy of lurasidone adjunctive therapy compared with treatment as usual (TAU) in improving cognition. METHODS: For this randomised, open-label, pilot study, we recruited patients aged 19-65 years with euthymic bipolar I disorder from the Mood Disorder Centre in UBC Hospital (Vancouver, Canada)...
March 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28104736/pharmacological-treatment-and-risk-of-psychiatric-hospital-admission-in-bipolar-disorder
#10
Erik Joas, Alina Karanti, Jie Song, Guy M Goodwin, Paul Lichtenstein, Mikael Landén
BackgroundClinical trials have examined the efficacy of drugs to prevent relapse in patients with bipolar disorder, however, their design often limits generalisation to routine clinical practice.AimsTo estimate the effectiveness of drugs used for maintenance treatment in bipolar disorder.MethodWe used national registers to identify 35 022 individuals diagnosed with bipolar disorder and information on lithium, valproate, carbamazepine, lamotrigine, quetiapine and olanzapine treatment from 2006 to 2009. The main outcome was psychiatric hospital admissions...
March 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28095412/intensive-versus-guideline-blood-pressure-and-lipid-lowering-in-patients-with-previous-stroke-main-results-from-the-pilot-prevention-of-decline-in-cognition-after-stroke-trial-podcast-randomised-controlled-trial
#11
Philip M Bath, Polly Scutt, Daniel J Blackburn, Sandeep Ankolekar, Kailash Krishnan, Clive Ballard, Alistair Burns, Jonathan Mant, Peter Passmore, Stuart Pocock, John Reckless, Nikola Sprigg, Rob Stewart, Joanna M Wardlaw, Gary A Ford
BACKGROUND: Stroke is associated with the development of cognitive impairment and dementia. We assessed the effect of intensive blood pressure (BP) and/or lipid lowering on cognitive outcomes in patients with recent stroke in a pilot trial. METHODS: In a multicentre, partial-factorial trial, patients with recent stroke, absence of dementia, and systolic BP (SBP) 125-170 mmHg were assigned randomly to at least 6 months of intensive (target SBP <125 mmHg) or guideline (target SBP <140 mmHg) BP lowering...
2017: PloS One
https://www.readbyqxmd.com/read/28052845/efficacy-and-effectiveness-of-screen-and-treat-policies-in-prevention-of-type-2-diabetes-systematic-review-and-meta-analysis-of-screening-tests-and-interventions
#12
REVIEW
Eleanor Barry, Samantha Roberts, Jason Oke, Shanti Vijayaraghavan, Rebecca Normansell, Trisha Greenhalgh
OBJECTIVES:  To assess diagnostic accuracy of screening tests for pre-diabetes and efficacy of interventions (lifestyle or metformin) in preventing onset of type 2 diabetes in people with pre-diabetes. DESIGN:  Systematic review and meta-analysis. DATA SOURCES AND METHOD:  Medline, PreMedline, and Embase. Study protocols and seminal papers were citation-tracked in Google Scholar to identify definitive trials and additional publications...
January 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28039296/effectiveness-of-senior-dance-on-risk-factors-for-falls-in-older-adults-danse-a-study-protocol-for-a-randomised-controlled-trial
#13
Marcia R Franco, Catherine Sherrington, Anne Tiedemann, Leani S Pereira, Monica R Perracini, Claudia R S Faria, Rafael Z Pinto, Carlos M Pastre
INTRODUCTION: Strong evidence shows that exercise is effective to improve fall risk factors among older people. However, older people's participation and adherence to exercise programmes is suboptimal. Type of exercise and apathy are reported to be barriers to exercise participation, suggesting that new effective interventions are needed. The primary aim of this randomised controlled trial is to investigate the effect of Senior Dance plus brief education for falls prevention on balance among people aged 60 years or over, compared with a control group receiving only brief education...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27892704/the-effects-of-a-16-week-aerobic-exercise-programme-on-cognitive-function-in-people-living-with-hiv
#14
Adam McDermott, Lilia Zaporojan, Patricia McNamara, Colin P Doherty, Janice Redmond, Cuisle Forde, John Gormley, Mikel Egaña, Colm Bergin
High levels of cardiovascular fitness and physical activity are associated with higher levels of cognitive function in people with HIV, thus, they may reduce the risk of developing HIV-associated neurocognitive disorder (HAND). This study aimed to investigate the effects of a 16-week aerobic exercise intervention on cognitive function in people with HIV. Eleven participants living with HIV were recruited into the study. Participants were randomised into either an exercise group (n = 5), that completed a 16-week aerobic exercise programme training, 3 times per week (2 supervised sessions and one unsupervised session) or a control group (n = 6) that received no intervention...
November 28, 2016: AIDS Care
https://www.readbyqxmd.com/read/27734555/the-effectiveness-of-pre-operative-clown-intervention-on-psychological-distress-a-systematic-review-and-meta-analysis
#15
Yongfu Zhang, Yuan Yang, Wing Yt Lau, Samradhvi Garg, Jianxin Lao
AIM: This study aims to provide an overview of the current knowledge available on the effectiveness of pre-operative clown intervention on psychological distress in children and parents. METHODS: PubMed, MEDLINE, Embase and PsycINFO databases were searched to identify relevant studies. Systematic review procedures were followed including a quality assessment. Meta-analysis of suitable studies was conducted. RESULTS: Eight studies were included; six reported that clown intervention reduced children's pre-operative anxiety, while one found that children's pre-operative distress levels were unchanged...
October 13, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27575534/social-dancing-and-incidence-of-falls-in-older-adults-a-cluster-randomised-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Dafna Merom, Erin Mathieu, Ester Cerin, Rachael L Morton, Judy M Simpson, Chris Rissel, Kaarin J Anstey, Catherine Sherrington, Stephen R Lord, Robert G Cumming
BACKGROUND: The prevention of falls among older people is a major public health challenge. Exercises that challenge balance are recognized as an efficacious fall prevention strategy. Given that small-scale trials have indicated that diverse dance styles can improve balance and gait of older adults, two of the strongest risk factors for falls in older people, this study aimed to determine whether social dance is effective in i) reducing the number of falls and ii) improving physical and cognitive fall-related risk factors...
August 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27501160/effectiveness-of-community-based-exercise-intervention-programme-in-obese-adults-with-metabolic-syndrome
#17
RANDOMIZED CONTROLLED TRIAL
Shu-Hung Chang, Miao-Chuan Chen, Nai-Hui Chien, Hsih-Fong Lin
AIMS AND OBJECTIVES: The objective of this study was to change the anthropometric, clinical, biochemical indicators and the rate of metabolic syndrome among obese adults in community. BACKGROUND: Obesity is an indicator of metabolic syndrome and cardiometabolic diseases. Obesity increases national health care expenditure in Taiwan. The high prevalence of obesity is not only a public health issue but also an economic problem. Changes in lifestyle can help to prevent metabolic syndrome for individuals with obesity...
September 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27344944/is-mechanical-curettage-with-adjunct-photodynamic-therapy-more-effective-in-the-treatment-of-peri-implantitis-than-mechanical-curettage-alone
#18
REVIEW
Alexis Ghanem, Sandeep Pasumarthy, Vinisha Ranna, Sergio Varela Kellesarian, Tariq Abduljabbar, Fahim Vohra, Hans Malmstrom
BACKGROUND: The aim of the present study was to review the pertinent literature on the effects of mechanical curettage (MC) with and without adjunct photodynamic therapy (PDT) for the management of peri-implantitis. METHODS: The addressed focused question was "Is PDT effective in the treatment of peri-implantitis?" A search without language or time restrictions up to March 2016 was conducted using various key words. The exclusion criteria included; review papers, in vitro Studies, case reports, commentaries, interviews, and letters to the editors...
September 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27301577/physical-impairments-in-symptomatic-femoroacetabular-impingement-a-systematic-review-of-the-evidence
#19
REVIEW
Matthew D Freke, Joanne Kemp, Ida Svege, May Arna Risberg, Adam Semciw, Kay M Crossley
BACKGROUND: Femoroacetabular impingement (FAI) and accompanying pathologies are associated with pain and reduced quality of life. Physical impairments can be associated with worse symptoms and may be an important target of rehabilitation programmes in this patient group. Knowledge regarding physical impairments in individuals with symptomatic FAI is limited. HYPOTHESIS: In adults aged 18-50 years with symptomatic FAI, to: (1) identify physical impairments in range of motion (ROM), hip muscle function and functional tasks; (2) to compare physical impairments with healthy controls; and (3) to evaluate the effects of interventions targeting physical impairments...
October 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27175917/the-value-of-arthroscopy-in-the-treatment-of-complex-ankle-fractures-a-protocol-of-a-randomised-controlled-trial
#20
Mareen Braunstein, Sebastian F Baumbach, Markus Regauer, Wolfgang Böcker, Hans Polzer
BACKGROUND: An anatomical reconstruction of the ankle congruity is the important prerequisite in the operative treatment of acute ankle fractures. Despite anatomic restoration patients regularly suffer from residual symptoms after these fractures. There is growing evidence, that a poor outcome is related to the concomitant traumatic intra-articular pathology. By supplementary ankle arthroscopy anatomic reduction can be confirmed and associated intra-articular injuries can be treated. Nevertheless, the vast majority of complex ankle fractures are managed by open reduction and internal fixation (ORIF) only...
May 12, 2016: BMC Musculoskeletal Disorders
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